Phenotypes for general behavior, activity, and body temperature in 3q29 deletion model mice Reviewed

Mori, D; Ikeda, R; Sawahata, M; Yamaguchi, S; Kodama, A; Hirao, T; Arioka, Y; Okumura, H; Inami, C; Suzuki, T; Hayashi, Y; Kato, H; Nawa, Y; Miyata, S; Kimura, H; Kushima, I; Aleksic, B; Mizoguchi, H; Nagai, T; Nakazawa, T; Hashimoto, R; Kaibuchi, K; Kume, K; Yamada, K; Ozaki, N

TRANSLATIONAL PSYCHIATRY   Vol. 14 ( 1 )   2024.3

Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction Reviewed

Ishikawa, M; Yamamoto, Y; Wulaer, B; Kunisawa, K; Fujigaki, H; Ando, T; Kimura, H; Kushima, I; Arioka, Y; Torii, Y; Mouri, A; Ozaki, N; Nabeshima, T; Saito, K

FEBS JOURNAL   Vol. 291 ( 5 ) page： 945 - 964   2024.3

Association between copy number variations in parkin (<i>PRKN</i>) and schizophrenia and autism spectrum disorder: A case-control study Reviewed

Lo, TY; Kushima, I; Kimura, H; Aleksic, B; Okada, T; Kato, H; Inada, T; Nawa, Y; Torii, Y; Yamamoto, M; Kimura, R; Funabiki, Y; Kosaka, H; Numata, S; Kasai, K; Sasaki, T; Yokoyama, S; Munesue, T; Hashimoto, R; Yasuda, Y; Fujimoto, M; Usami, M; Itokawa, M; Arai, M; Ohi, K; Someya, T; Watanabe, Y; Egawa, J; Takahashi, T; Suzuki, M; Yamasue, H; Iwata, N; Ikeda, M; Ozaki, N

Neuropsychopharmacology Reports   Vol. 44 ( 1 ) page： 42 - 50   2024.3

Mesenchymal stem/stromal cells generated from induced pluripotent stem cells are highly resistant to senescence Reviewed

Aoi, T; Tanaka, A; Furuhashi, K; Ikeya, M; Shimizu, A; Arioka, Y; Kushima, I; Ozaki, N; Maruyama, S

NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 85 ( 4 ) page： 682 - 690   2023.11

Case reports of two siblings with autism spectrum disorder and 15q13.3 deletions Reviewed

Furukawa, S; Kushima, I; Aleksic, B; Ozaki, N

NEUROPSYCHOPHARMACOLOGY REPORTS   Vol. 43 ( 3 ) page： 462 - 466   2023.9

De novo<i> MCM6</i> variants in neurodevelopmental disorders: a recognizable phenotype related to zinc binding residues Reviewed

Smits, DJ; Schot, R; Popescu, CA; Dias, KR; Ades, L; Briere, LC; Sweetser, DA; Kushima, I; Aleksic, B; Khan, S; Karageorgou, V; Ordonez, N; Sleutels, FJGT; van der Kaay, DCM; Van Mol, C; Van Esch, H; Bertoli-Avella, AM; Roscioli, T; Mancini, GMS

HUMAN GENETICS   Vol. 142 ( 7 ) page： 949 - 964   2023.7

Structural aging of human neurons is opposite of the changes in schizophrenia Reviewed

Mizutani, R; Saiga, R; Yamamoto, Y; Uesugi, M; Takeuchi, A; Uesugi, K; Terada, Y; Suzuki, Y; De Andrade, V; De Carlo, F; Takekoshi, S; Inomoto, C; Nakamura, N; Torii, Y; Kushima, I; Iritani, S; Ozaki, N; Oshima, K; Itokawa, M; Arai, M

PLOS ONE   Vol. 18 ( 6 )   2023.6

The clinical and molecular spectrum of the <i>KDM6B</i>-related neurodevelopmental disorder Reviewed

Rots, D; Jakub, TE; Keung, C; Lisenka, VELM; Banka, S; Pfundt, R; de Vries, BBA; van Jaarsveld, RH; Hopman, SMJ; van Binsbergen, E; Valenzuela, I; Hempel, M; Bierhals, T; Kortüm, F; Lecoquierre, F; Goldenberg, A; Hertz, JM; Andersen, CB; Kibaek, M; Prijoles, EJ; Stevenson, RE; Everman, DB; Patterson, WG; Meng, LY; Gijavanekar, C; De Dios, K; Lakhani, S; Levy, T; Wagner, M; Wieczorek, D; Benke, PJ; Garcia, MSL; Perrier, R; Sousa, SB; Almeida, PM; Simoes, MJ; Isidor, B; Deb, W; Schmanski, AA; Abdul-Rahman, O; Philippe, C; Bruel, AL; Faivre, L; Vitobello, A; Thauvin, C; Smits, JJ; Garavelli, L; Caraffi, SG; Peluso, F; Davis-Keppen, L; Platt, D; Royer, E; Leeuwen, L; Sinnema, M; Stegmann, APA; Stumpel, CTRM; Tiller, GE; Bosch, DSDLGM; Potgieter, ST; Joss, S; Splitt, M; Holden, S; Prapa, M; Foulds, N; Douzgou, S; Puura, K; Waltes, R; Chiocchetti, AG; Freitag, CM; Satterstrom, FK; De Rubeis, S; Buxbaum, J; Gelb, BD; Branko, A; Kushima, I; Howe, J; Scherer, SW; Arado, A; Baldo, C; Patat, O; Benedicte, D; Lopergolo, D; Santorelli, FM; Haack, TB; Dufke, A; Bertrand, M; Falb, RJ; Riess, A; Krieg, P; Spranger, S; Bedeschi, MF; Iascone, M; Josephi-Taylor, S; Roscioli, T; Buckley, MF; Liebelt, J; Dagli, AI; Aten, E; Hurst, ACE; Hicks, A; Suri, M; Aliu, E; Naik, S; Sidlow, R; Coursimault, J; Nicolas, G; Küpper, H; Petit, F; Ibrahim, V; Top, D; Di Cara, F; Louie, RJ; Stolerman, E; Brunner, HG; Vissers, LELM; Kramer, JM; Kleefstra, T

AMERICAN JOURNAL OF HUMAN GENETICS   Vol. 110 ( 6 ) page： 963 - 978   2023.6

Clinical characterization of patients with schizophrenia and 16p13.11 duplication: A case series Reviewed

Kimura, H; Kushima, I; Banno, M; Inada, T; Yoshimi, A; Aleksic, B; Ozaki, N

NEUROPSYCHOPHARMACOLOGY REPORTS   Vol. 43 ( 2 ) page： 267 - 271   2023.6

Astrotactin 2 (ASTN2) regulates emotional and cognitive functions by affecting neuronal morphogenesis and monoaminergic systems Reviewed

Ito, T; Yoshida, M; Aida, T; Kushima, I; Hiramatsu, Y; Ono, M; Yoshimi, A; Tanaka, K; Ozaki, N; Noda, Y

JOURNAL OF NEUROCHEMISTRY   Vol. 165 ( 2 ) page： 211 - 229   2023.4

Molecular diagnosis of 405 individuals with autism spectrum disorder Reviewed

Miyake, N; Tsurusaki, Y; Fukai, R; Kushima, I; Okamoto, N; Ohashi, K; Nakamura, K; Hashimoto, R; Hiraki, Y; Son, S; Kato, M; Sakai, Y; Osaka, H; Deguchi, K; Matsuishi, T; Takeshita, S; Fattal-Valevski, A; Ekhilevitch, N; Tohyama, J; Yap, P; Keng, WT; Kobayashi, H; Takubo, K; Okada, T; Saitoh, S; Yasuda, Y; Murai, T; Nakamura, K; Ohga, S; Matsumoto, A; Inoue, K; Saikusa, T; Hershkovitz, T; Kobayashi, Y; Morikawa, M; Ito, A; Hara, T; Uno, Y; Seiwa, C; Ishizuka, K; Shirahata, E; Fujita, A; Koshimizu, E; Miyatake, S; Takata, A; Mizuguchi, T; Ozaki, N; Matsumoto, N

EUROPEAN JOURNAL OF HUMAN GENETICS     2023.3

The genetic architecture of schizophrenia: review of large-scale genetic studies Reviewed

Kato, H; Kimura, H; Kushima, I; Takahashi, N; Aleksic, B; Ozaki, N

JOURNAL OF HUMAN GENETICS   Vol. 68 ( 3 ) page： 175 - 182   2023.3

A case of bipolar disorder with <i>AIF1</i> (coding gene of Iba-1) deletion: A pilot <i>in vitro</i> analysis using blood-derived microglia-like cells Reviewed

Ohgidani, M; Kushima, I; Inamine, S; Kyuragi, S; Sagata, N; Nakao, T; Kanba, S; Ozaki, N; Kato, TA

PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 77 ( 2 ) page： 128 - 130   2023.2

Clinical manifestations of schizophrenia in four patients with variants in voltage-gated calcium channel-encoding genes: a case series Reviewed

Lo, TY; Kushima, I; Aleksic, B; Yoshimi, A; Someya, T; Watanabe, Y; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 77 ( 1 ) page： 57 - 59   2023.1

X chromosome aneuploidies and schizophrenia: association analysis and phenotypic characterization Reviewed

Kushima, I; Aleksic, B; Kimura, H; Nakatochi, M; Lo, T; Ikeda, M; Arai, M; Hashimoto, R; Numata, S; Okamura, Y; Obara, T; Inada, T; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 76 ( 12 ) page： 667 - 673   2022.12

Turner syndrome presenting with idiopathic regression: A case report Reviewed

Mizobuchi, K; Kushima, I; Kato, H; Miyajima, M; Kimura, H; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 76 ( 12 ) page： 680 - 682   2022.12

Establishment of induced pluripotent stem cells from a patient with 16p13.11 duplication and VPS13B deletion Reviewed

Okumura, H; Arioka, Y; Kushima, I; Mori, D; Ozaki, N

STEM CELL RESEARCH   Vol. 64   2022.10

Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder Reviewed

Kushima, I; Nakatochi, M; Aleksic, B; Okada, T; Kimura, H; Kato, H; Morikawa, M; Inada, T; Ishizuka, K; Torii, Y; Nakamura, Y; Tanaka, S; Imaeda, M; Takahashi, N; Yamamoto, M; Iwamoto, K; Nawa, Y; Ogawa, N; Iritani, S; Hayashi, Y; Lo, TY; Otgonbayar, G; Furuta, S; Iwata, N; Ikeda, M; Saito, T; Ninomiya, K; Okochi, T; Hashimoto, R; Yamamori, H; Yasuda, Y; Fujimoto, M; Miura, K; Itokawa, M; Arai, M; Miyashita, M; Toriumi, K; Ohi, K; Shioiri, T; Kitaichi, K; Someya, T; Watanabe, Y; Egawa, J; Takahashi, T; Suzuki, M; Sasaki, T; Tochigi, M; Nishimura, F; Yamasue, H; Kuwabara, H; Wakuda, T; Kato, TA; Kanba, S; Horikawa, H; Usami, M; Kodaira, M; Watanabe, K; Yoshikawa, T; Toyota, T; Yokoyama, S; Munesue, T; Kimura, R; Funabiki, Y; Kosaka, H; Jung, MY; Kasai, K; Ikegame, T; Jinde, S; Numata, S; Kinoshita, M; Kato, T; Kakiuchi, C; Yamakawa, K; Suzuki, T; Hashimoto, N; Ishikawa, S; Yamagata, B; Nio, S; Murai, T; Son, S; Kunii, Y; Yabe, H; Inagaki, M; Goto, Y; Okumura, Y; Ito, T; Arioka, Y; Mori, D; Ozaki, N

BIOLOGICAL PSYCHIATRY   Vol. 92 ( 5 ) page： 362 - 374   2022.9

Contribution of copy number variations to the risk of severe eating disorders Reviewed

Kushima, I; Imaeda, M; Tanaka, S; Kato, H; Oya-Ito, T; Nakatochi, M; Aleksic, B; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 76 ( 9 ) page： 423 - 428   2022.9

Rare coding variation provides insight into the genetic architecture and phenotypic context of autism Invited Reviewed

Nature Genetics     2022.9

Exome sequencing analysis of Japanese autism spectrum disorder case-control sample supports an increased burden of synaptic function-related genes Reviewed

Kimura, H; Nakatochi, M; Aleksic, B; Guevara, J; Toyama, M; Hayashi, Y; Kato, H; Kushima, I; Morikawa, M; Ishizuka, K; Okada, T; Tsurusaki, Y; Fujita, A; Miyake, N; Ogi, T; Takata, A; Matsumoto, N; Buxbaum, J; Ozaki, N; Sebat, J

TRANSLATIONAL PSYCHIATRY   Vol. 12 ( 1 )   2022.7

Exonic deletions in <i>IMMP2L</i> in schizophrenia with enhanced glycation stress subtype

Yoshikawa, A; Kushima, I; Miyashita, M; Suzuki, K; Iino, K; Toriumi, K; Horiuchi, Y; Kawaji, H; Ozaki, N; Itokawa, M; Arai, M

PLOS ONE   Vol. 17 ( 7 )   2022.7

Treatment-resistant schizophrenia in patients with 3q29 deletion: A case series of four patients Reviewed

Nawa, Y; Kushima, I; Aleksic, B; Yamamoto, M; Kimura, H; Banno, M; Hashimoto, R; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 76 ( 7 ) page： 338 - 339   2022.7

Psychiatric patients with a <i>de novo</i> 17q12 deletion: Two case reports Reviewed

Kushima, I; Uematsu, M; Ishizuka, K; Aleksic, B; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 76 ( 7 ) page： 345 - 347   2022.7

Identification of rare mutations of the vasoactive intestinal peptide receptor 2 gene in schizophrenia

Chen, CH; Cheng, MC; Hu, TM; Ping, LY; Kushima, I; Aleksic, B

PSYCHIATRIC GENETICS   Vol. 32 ( 3 ) page： 125 - 130   2022.6

Investigation of<i> OLIG2</i> as a candidate gene for schizophrenia and autism spectrum disorder

Furuta, S; Aleksic, B; Nawa, Y; Kimura, H; Kushima, I; Ishizuka, K; Kato, H; Toyama, M; Arioka, Y; Mori, D; Morikawa, M; Inada, T; Ozaki, N

NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 2 ) page： 260 - 268   2022.5

Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial

Yamasue, H; Kojima, M; Kuwabara, H; Kuroda, M; Matsumoto, K; Kanai, C; Inada, N; Owada, K; Ochi, K; Ono, N; Benner, S; Wakuda, T; Kameno, Y; Inoue, J; Harada, T; Tsuchiya, K; Umemura, K; Yamauchi, A; Ogawa, N; Kushima, I; Ozaki, N; Suyama, S; Saito, T; Uemura, Y; Hamada, J; Kano, Y; Honda, N; Kikuchi, S; Seto, M; Tomita, H; Miyoshi, N; Matsumoto, M; Kawaguchi, Y; Kanai, K; Ikeda, M; Nakamura, I; Isomura, S; Hirano, Y; Onitsuka, T; Kosaka, H; Okada, T

BRAIN   Vol. 145 ( 2 ) page： 490 - 499   2022.4

Case report of a female with bipolar disorder and <i>MBD5</i> deletion

Kushima, I; Lo, T; Aleksic, B; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 76 ( 4 ) page： 127 - 128   2022.4

Variable psychiatric manifestations in patients with 16p11.2 duplication: a case series of 4 patients. Reviewed

Psychiatry Clin Neurosci.     2022.3

Variable psychiatric manifestations in patients with 16p11.2 duplication: a case series of 4 patients

Hayashi, Y; Kushima, I; Aleksic, B; Senaha, T; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 76 ( 3 ) page： 86 - 88   2022.3

Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder

Wang, CY; Horigane, S; Wakamori, M; Ueda, S; Kawabata, T; Fujii, H; Kushima, I; Kimura, H; Ishizuka, K; Nakamura, Y; Iwayama, Y; Ikeda, M; Iwata, N; Okada, T; Aleksic, B; Mori, D; Yoshida, T; Bito, H; Yoshikawa, T; Takemoto-Kimura, S; Ozaki, N

TRANSLATIONAL PSYCHIATRY   Vol. 12 ( 1 )   2022.2

Sequencing of selected chromatin remodelling genes reveals increased burden of rare missense variants in ASD patients from the Japanese population

Lo, T; Kushima, I; Aleksic, B; Kato, H; Nawa, Y; Hayashi, Y; Otgonbayar, G; Kimura, H; Arioka, Y; Mori, D; Ozaki, N

INTERNATIONAL REVIEW OF PSYCHIATRY   Vol. 34 ( 2 ) page： 154 - 167   2022.2

Autism spectrum disorder comorbid with obsessive compulsive disorder and eating disorder in a woman with <i>NBEA</i> deletion

Kato, H; Kushima, I; Yoshimi, A; Ishizuka, K; Kimura, H; Aleksic, B; Takahashi, N; Okada, T; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 76 ( 1 ) page： 36 - 38   2022.1

Trends in big data analyses by multicenter collaborative translational research in psychiatry

Onitsuka, T; Hirano, Y; Nemoto, K; Hashimoto, N; Kushima, I; Koshiyama, D; Koeda, M; Takahashi, T; Noda, Y; Matsumoto, J; Miura, K; Nakazawa, T; Hikida, T; Kasai, K; Ozaki, N; Hashimoto, R

PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 76 ( 1 ) page： 1 - 14   2022.1

Case report of a female with bipolar disorder and MBD5 deletion. Reviewed

Psychiatry Clin Neurosci.     2022

Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder. Reviewed

Transl Psychiatry     2022

Cross-disorder analysis of genic and regulatory copy number variations in bipolar disorder, schizophrenia, and autism spectrum disorder Reviewed

Itaru Kushima, Masahiro Nakatochi, Branko Aleksic, Takashi Okada, Hiroki Kimura, Hidekazu Kato, Mako Morikawa, Toshiya Inada, Kanako Ishizuka, Youta Torii, Yukako Nakamura, Satoshi Tanaka, Miho Imaeda, Nagahide Takahashi, Maeri Yamamoto, Kunihiro Iwamoto, Yoshihiro Nawa, Nanayo Ogawa, Shuji Iritani, Yu Hayashi, Tzuyao Lo, Gantsooj Otgonbayar, Sho Furuta, Nakao Iwata, Masashi Ikeda, Takeo Saito, Kohei Ninomiya, Tomo Okochi, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Kenichiro Miura, Masanari Itokawa, Makoto Arai, Mitsuhiro Miyashita, Kazuya Toriumi, Kazutaka Ohi, Toshiki Shioiri, Kiyoyuki Kitaichi, Toshiyuki Someya, Yuichiro Watanabe, Jun Egawa, Tsutomu Takahashi, Michio Suzuki, Tsukasa Sasaki, Mamoru Tochigi, Fumichika Nishimura, Hidenori Yamasue, Hitoshi Kuwabara, Tomoyasu Wakuda, Takahiro A. Kato, Shigenobu Kanba, Hideki Horikawa, Masahide Usami, Masaki Kodaira, Kyota Watanabe, Takeo Yoshikawa, Tomoko Toyota, Shigeru Yokoyama, Toshio Munesue, Ryo Kimura, Yasuko Funabiki, Hirotaka Kosaka, Minyoung Jung, Kiyoto Kasai, Tempei Ikegame, Seiichiro Jinde, Shusuke Numata, Makoto Kinoshita, Tadafumi Kato, Chihiro Kakiuchi, Kazuhiro Yamakawa, Toshimitsu Suzuki, Naoki Hashimoto, Shuhei Ishikawa, Bun Yamagata, Shintaro Nio, Toshiya Murai, Shuraku Son, Yasuto Kunii, Hirooki Yabe, Masumi Inagaki, Yu-ichi Goto, Yuto Okumura, Tomoya Ito, Yuko Arioka, Daisuke Mori, Norio Ozaki

Biological Psychiatry     2022

Exome sequencing of Japanese schizophrenia multiplex families supports the involvement of calcium ion channels

Toyama, M; Takasaki, Y; Branko, A; Kimura, H; Kato, H; Nawa, Y; Kushima, I; Ishizuka, K; Shimamura, T; Ogi, T; Ozaki, N

PLOS ONE   Vol. 17 ( 5 )   2022

<i>AKR1A1</i> Variant Associated With Schizophrenia Causes Exon Skipping, Leading to Loss of Enzymatic Activity

Iino, K; Toriumi, K; Agarie, R; Miyashita, M; Suzuki, K; Horiuchi, Y; Niizato, K; Oshima, K; Imai, A; Nagase, Y; Kushima, I; Koike, S; Ikegame, T; Jinde, S; Nagata, E; Washizuka, S; Miyata, T; Takizawa, S; Hashimoto, R; Kasai, K; Ozaki, N; Itokawa, M; Arai, M

FRONTIERS IN GENETICS   Vol. 12   2021.12

Brain capillary structures of schizophrenia cases and controls show a correlation with their neuron structures

Saiga, R; Uesugi, M; Takeuchi, A; Uesugi, K; Suzuki, Y; Takekoshi, S; Inomoto, C; Nakamura, N; Torii, Y; Kushima, I; Iritani, S; Ozaki, N; Oshima, K; Itokawa, M; Arai, M; Mizutani, R

SCIENTIFIC REPORTS   Vol. 11 ( 1 )   2021.6

Dysregulation of post-transcriptional modification by copy number variable microRNAs in schizophrenia with enhanced glycation stress

Yoshikawa, A; Kushima, I; Miyashita, M; Toriumi, K; Suzuki, K; Horiuchi, Y; Kawaji, H; Takizawa, S; Ozaki, N; Itokawa, M; Arai, M

TRANSLATIONAL PSYCHIATRY   Vol. 11 ( 1 )   2021.5

Two novel mouse models mimicking minor deletions in 22q11.2 deletion syndrome revealed the contribution of each deleted region to psychiatric disorders

Saito, R; Miyoshi, C; Koebis, M; Kushima, I; Nakao, K; Mori, D; Ozaki, N; Funato, H; Yanagisawa, M; Aiba, A

MOLECULAR BRAIN   Vol. 14 ( 1 )   2021.4

Resequencing and association analysis of GAP43 with autism spectrum disorder and schizophrenia in a Japanese population Reviewed

Arta Reza K., Watanabe Yuichiro, Inoue Emiko, Nawa Yoshihiro, Morikawa Ryo, Egawa Jun, Kushima Itaru, Igeta Hirofumi, Hoya Satoshi, Sugimoto Atsunori, Tanra Andi J., Ozaki Norio, Someya Toshiyuki

  Vol. 82   2021.4

Mice carrying a schizophrenia-associated mutation of the <i>Arhgap10</i> gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons Reviewed

Hada, K; Wulaer, B; Nagai, T; Itoh, N; Sawahata, M; Sobue, A; Mizoguchi, H; Mori, D; Kushima, I; Nabeshima, T; Ozaki, N; Yamada, K

MOLECULAR BRAIN   Vol. 14 ( 1 )   2021.1

Structural diverseness of neurons between brain areas and between cases Reviewed

Mizutani Ryuta, Saiga Rino, Yamamoto Yoshiro, Uesugi Masayuki, Takeuchi Akihisa, Uesugi Kentaro, Terada Yasuko, Suzuki Yoshio, De Andrade Vincent, De Carlo Francesco, Takekoshi Susumu, Inomoto Chie, Nakamura Naoya, Torii Youta, Kushima Itaru, Iritani Shuji, Ozaki Norio, Oshima Kenichi, Itokawa Masanari, Arai Makoto

  Vol. 11 ( 1 )   2021.1

Implications of germline copy-number variations in psychiatric disorders: review of large-scale genetic studies Reviewed

Nakatochi, M; Kushima, I; Ozaki, N

JOURNAL OF HUMAN GENETICS   Vol. 66 ( 1 ) page： 25 - 37   2021.1

Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons Reviewed

  Vol. 63   2021.1

Rare genetic variants in the gene encoding histone lysine demethylase 4C (<i>KDM4C</i>) and their contributions to susceptibility to schizophrenia and autism spectrum disorder Reviewed

Kato, H; Kushima, I; Mori, D; Yoshimi, A; Aleksic, B; Nawa, Y; Toyama, M; Furuta, S; Yu, YJ; Ishizuka, K; Kimura, H; Arioka, Y; Tsujimura, K; Morikawa, M; Okada, T; Inada, T; Nakatochi, M; Shinjo, K; Kondo, Y; Kaibuchi, K; Funabiki, Y; Kimura, R; Suzuki, T; Yamakawa, K; Ikeda, M; Iwata, N; Takahashi, T; Suzuki, M; Okahisa, Y; Takaki, M; Egawa, J; Someya, T; Ozaki, N

TRANSLATIONAL PSYCHIATRY   Vol. 10 ( 1 )   2020.12

Involvement of nicotinic acetylcholine receptors in behavioral abnormalities and psychological dependence in schizophrenia-like model mice Reviewed

Noda Yukihiro, Uchida Mizuki, Mouri Akihiro, Yamada Shokuro, Goto Sakika, Kitagaki Shinji, Mamiya Takayoshi, Kushima Itaru, Arioka Yuko, Ozaki Norio, Yoshimi Akira

  Vol. 41   page： 92 - 105   2020.12

Support vector machine-based classification of schizophrenia patients and healthy controls using structural magnetic resonance imaging from two independent sites Reviewed

Yamamoto Maeri, Bagarinao Epifanio, Kushima Itaru, Takahashi Tsutomu, Sasabayashi Daiki, Inada Toshiya, Suzuki Michio, Iidaka Tetsuya, Ozaki Norio

  Vol. 15 ( 11 )   2020.11

Rare single-nucleotide <i>DAB1</i> variants and their contribution to Schizophrenia and autism spectrum disorder susceptibility Reviewed

Nawa, Y; Kimura, H; Mori, D; Kato, H; Toyama, M; Furuta, S; Yu, YJ; Ishizuka, K; Kushima, I; Aleksic, B; Arioka, Y; Morikawa, M; Okada, T; Inada, T; Kaibuchi, K; Ikeda, M; Iwata, N; Suzuki, M; Okahisa, Y; Egawa, J; Someya, T; Nishimura, F; Sasaki, T; Ozaki, N

HUMAN GENOME VARIATION   Vol. 7 ( 1 )   2020.11

Functional characterization of rare NRXN1 variants identified in autism spectrum disorders and schizophrenia Reviewed

Ishizuka Kanako, Yoshida Tomoyuki, Kawabata Takeshi, Imai Ayako, Mori Hisashi, Kimura Hiroki, Inada Toshiya, Okahisa Yuko, Egawa Jun, Usami Masahide, Kushima Itaru, Morikawa Mako, Okada Takashi, Ikeda Masashi, Branko Aleksic, Mori Daisuke, Someya Toshiyuki, Iwata Nakao, Ozaki Norio

  Vol. 12 ( 1 )   2020.9

The accumulation of advanced glycation end-products in a schizophrenic patient with a glyoxalase 1 frameshift mutation: An autopsy study Reviewed

Torii Youta, Iritani Shuji, Sekiguchi Hirotaka, Habuchi Chikako, Fujishiro Hiroshige, Kushima Itaru, Kawakami Ito, Itokawa Masanari, Arai Makoto, Hayashida Shotaro, Masaki Katsuhisa, Kira Jun-ichi, Kawashima Kunihiro, Ozaki Norio

  Vol. 223   page： 356 - 358   2020.9

Morphological alteration of myelin-oligodendrocytes in a schizophrenic patient with 22q11.2 deletion syndrome: An autopsy study

Torii, Y; Iritani, S; Marui, T; Sekiguchi, H; Habuchi, C; Fujishiro, H; Kushima, I; Oshima, K; Niizato, K; Hayashida, S; Masaki, K; Kira, J; Yoshida, M; Ozaki, N

SCHIZOPHRENIA RESEARCH   Vol. 223   page： 353 - 355   2020.9

Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial Reviewed

Yamasue, H; Okada, T; Munesue, T; Kuroda, M; Fujioka, T; Uno, Y; Matsumoto, K; Kuwabara, H; Mori, D; Okamoto, Y; Yoshimura, Y; Kawakubo, Y; Arioka, Y; Kojima, M; Yuhi, T; Owada, K; Yassin, W; Kushima, I; Benner, S; Ogawa, N; Eriguchi, Y; Kawano, N; Uemura, Y; Yamamoto, M; Kano, Y; Kasai, K; Higashida, H; Ozaki, N; Kosaka, H

MOLECULAR PSYCHIATRY   Vol. 25 ( 8 ) page： 1849 - 1858   2020.8

<i>ARHGAP10</i>, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk Reviewed

Sekiguchi, M; Sobue, A; Kushima, I; Wang, CY; Arioka, Y; Kato, H; Kodama, A; Kubo, H; Ito, N; Sawahata, M; Hada, K; Ikeda, R; Shinno, M; Mizukoshi, C; Tsujimura, K; Yoshimi, A; Ishizuka, K; Takasaki, Y; Kimura, H; Xing, JR; Yu, YJ; Yamamoto, M; Okada, T; Shishido, E; Inada, T; Nakatochi, M; Takano, T; Kuroda, K; Amano, M; Aleksic, B; Yamomoto, T; Sakuma, T; Aida, T; Tanaka, K; Hashimoto, R; Arai, M; Ikeda, M; Iwata, N; Shimamura, T; Nagai, T; Nabeshima, T; Kaibuchi, K; Yamada, K; Mori, D; Ozaki, N

TRANSLATIONAL PSYCHIATRY   Vol. 10 ( 1 )   2020.7

A recurrentPJA1variant in trigonocephaly and neurodevelopmental disorders Reviewed

Suzuki Toshimitsu, Suzuki Toshifumi, Raveau Matthieu, Miyake Noriko, Sudo Genki, Tsurusaki Yoshinori, Watanabe Takaki, Sugaya Yuki, Tatsukawa Tetsuya, Mazaki Emi, Shimohata Atsushi, Kushima Itaru, Aleksic Branko, Shiino Tomoko, Toyota Tomoko, Iwayama Yoshimi, Nakaoka Kentaro, Ohmori Iori, Sasaki Aya, Watanabe Ken, Hirose Shinichi, Kaneko Sunao, Inoue Yushi, Yoshikawa Takeo, Ozaki Norio, Kano Masanobu, Shimoji Takeyoshi, Matsumoto Naomichi, Yamakawa Kazuhiro

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY   Vol. 7 ( 7 ) page： 1117 - 1131   2020.7

Generation and analysis of novel Reln-deleted mouse model corresponding to exonic Reln deletion in schizophrenia Reviewed

Sawahata Masahito, Mori Daisuke, Arioka Yuko, Kubo Hisako, Kushima Itaru, Kitagawa Kanako, Sobue Akira, Shishido Emiko, Sekiguchi Mariko, Kodama Akiko, Ikeda Ryosuke, Aleksic Branko, Kimura Hiroki, Ishizuka Kanako, Nagai Taku, Kaibuchi Kozo, Nabeshima Toshitaka, Yamada Kiyofumi, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 74 ( 5 ) page： 318 - 327   2020.5

Cell body shape and directional movement stability in human-induced pluripotent stem cell-derived dopaminergic neurons Reviewed

Arioka Yuko, Shishido Emiko, Kushima Itaru, Mori Daisuke, Ozaki Norio

SCIENTIFIC REPORTS   Vol. 10 ( 1 )   2020.4

Cutting-edge morphological studies of post-mortem brains of patients with schizophrenia and potential applications of X-ray nanotomography (nano-CT)

Itokawa Masanari, Oshima Kenichi, Arai Makoto, Torii Yota, Kushima Itaru, Iritani Shuji, Ozaki Norio, Saiga Rino, Mizutani Ryuta

PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 74 ( 3 ) page： 176 - 182   2020.3

Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus

Saito Ryo, Koebis Michinori, Nagai Taku, Shimizu Kimiko, Liao Jingzhu, Wulaer Bolati, Sugaya Yuki, Nagahama Kenichiro, Uesaka Naofumi, Kushima Itaru, Mori Daisuke, Maruyama Kazuaki, Nakao Kazuki, Kurihara Hiroki, Yamada Kiyofumi, Kano Masanobu, Fukada Yoshitaka, Ozaki Norio, Aiba Atsu

TRANSLATIONAL PSYCHIATRY   Vol. 10 ( 1 )   2020.2

Characterization of a schizophrenia patient with a rare RELN deletion by combining genomic and patient-derived cell analyses

Arioka Yuko, Hirata Akihiro, Kushima Itaru, Aleksic Branko, Mori Daisuke, Ozaki Norio

SCHIZOPHRENIA RESEARCH   Vol. 216   page： 511 - 515   2020.2

Polygenic risk scores in schizophrenia with clinically significant copy number variants

Taniguchi Satoru, Ninomiya Kohei, Kushima Itaru, Saito Takeo, Shimasaki Ayu, Sakusabe Takaya, Momozawa Yukihide, Kubo Michiaki, Kamatani Yoichiro, Ozaki Norio, Ikeda Masashi, Iwata Nakao

PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 74 ( 1 ) page： 35 - 39   2020.1

A network of networks approach for modeling interconnected brain tissue-specific networks

Kawakubo Hideko, Matsui Yusuke, Kushima Itaru, Ozaki Norio, Shimamura Teppei

BIOINFORMATICS   Vol. 35 ( 17 ) page： 3092 - 3101   2019.9

In Vitro Modeling of the Bipolar Disorder and Schizophrenia Using Patient-Derived Induced Pluripotent Stem Cells with Copy Number Variations of PCDH15 and RELN

Ishii Takaya, Ishikawa Mitsuru, Fujimori Koki, Maeda Takuji, Kushima Itaru, Arioka Yuko, Mori Daisuke, Nakatake Yuhki, Yamagata Bun, Nio Shintaro, Kato Takahiro A., Yang Nan, Wernig Marius, Kanba Shigenobu, Mimura Masaru, Ozaki Norio, Okano Hideyuki

ENEURO   Vol. 6 ( 5 )   2019.9

Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect

Ikeda Masashi, Takahashi Atsushi, Kamatanim Yoichiro, Momozawa Yukihide, Saito Takeo, Kondo Kenji, Shimasaki Ayu, Kawase Kohei, Sakusabe Takaya, Iwayama Yoshimi, Toyota Tomoko, Wakudas Tomoyasu, Kikuchi Mitsuru, Kanahara Nobuhisa, Yamamori Hidenaga, Yasuda Yuka, Watanabe Yuichiro, Hoya Satoshi, Aleksic Branko, Kushima Itaru, Arai Heii, Takaki Manabu, Hattori Kotaro, Kurrugi Hiroshi, Okahisa Yuko, Ohnuma Tohru, Ozaki Norio, Someya Toshiyuki, Hashimotovs Ryota, Yoshikawa Takeo, Kubo Michiaki, Iwata Nakao

SCHIZOPHRENIA BULLETIN   Vol. 45 ( 4 ) page： 824 - 834   2019.7

Quantitative facial expression analysis revealed the efficacy and time course of oxytocin in autism

Owada Keiho, Okada Takashi, Munesue Toshio, Kuroda Miho, Fujioka Toru, Uno Yota, Matsumoto Kaori, Kuwabara Hitoshi, Mori Daisuke, Okamoto Yuko, Yoshimura Yuko, Kawakubo Yuki, Arioka Yuko, Kojima Masaki, Yuhi Teruko, Yassin Walid, Kushima Itaru, Benner Seico, Ogawa Nanayo, Kawano Naoko, Eriguchi Yosuke, Uemura Yukari, Yamamoto Maeri, Kano Yukiko, Kasai Kiyoto, Higashida Haruhiro, Ozaki Norio, Kosaka Hirotaka, Yamasue Hidenori

BRAIN   Vol. 142   page： 2127 - 2136   2019.7

Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients

Yoshimi Akira, Yamada Shinnosuke, Kunimoto Shohko, Aleksic Branko, Hirakawa Akihiro, Ohashi Mitsuki, Matsumoto Yurie, Hada Kazuhiro, Itoh Norimichi, Arioka Yuko, Kimura Hiroki, Kushima Itaru, Nakamura Yukako, Shiino Tomoko, Mori Daisuke, Tanaka Satoshi, Hamada Shuko, Noda Yukihiro, Nagai Taku, Yamada Kiyofumi, Ozaki Norio

TRANSLATIONAL PSYCHIATRY   Vol. 9   2019.4

Three-dimensional alteration of neurites in schizophrenia

Mizutani Ryuta, Saiga Rino, Takeuchi Akihisa, Uesugi Kentaro, Terada Yasuko, Suzuki Yoshio, De Andrade Vincent, De Carlo Francesco, Takekoshi Susumu, Inomoto Chie, Nakamura Naoya, Kushima Itaru, Iritani Shuji, Ozaki Norio, Ide Soichiro, Ikeda Kazutaka, Oshima Kenichi, Itokawa Masanari, Arai Makoto

TRANSLATIONAL PSYCHIATRY   Vol. 9   2019.2

A NOVEL RARE VARIANT R292H IN RTN4R AFFECTS GROWTH CONE FORMATION AND POSSIBLY CONTRIBUTES TO SCHIZOPHRENIA SUSCEPTIBILITY

Kimura Hiroki, Ishizuka Kanako, Wang Chenyao, Kushima Itaru, Morikawa Mako, Uno Yota, Okada Takashi, Inanda Toshiya, Aleksic Branko, Mori Daisuke, Ozaki Norio

EUROPEAN NEUROPSYCHOPHARMACOLOGY   Vol. 29   page： S1014 - S1014   2019

Dysregulation of schizophrenia-related aquaporin 3 through disruption of paranode influences neuronal viability

Kunisawa Kazuo, Shimizu Takeshi, Kushima Itaru, Aleksic Branko, Mori Daisuke, Osanai Yasuyuki, Kobayashi Kenta, Taylor Anna M., Bhat Manzoor A., Hayashi Akiko, Baba Hiroko, Ozaki Norio, Ikenaka Kazuhiro

JOURNAL OF NEUROCHEMISTRY   Vol. 147 ( 3 ) page： 395 - 408   2018.11

Assessment of a glyoxalase I frameshift variant, p.P122fs, in Japanese patients with schizophrenia

Ishizuka Kanako, Kimura Hiroki, Kushima Itaru, Inada Toshiya, Okahisa Yuko, Ikeda Masashi, Iwata Nakao, Mori Daisuke, Aleksic Branko, Ozaki Norio

PSYCHIATRIC GENETICS   Vol. 28 ( 5 ) page： 90 - 93   2018.10

Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights Reviewed

Kushima Itaru, Aleksic Branko, Nakatochi Masahiro, Shimamura Teppei, Okada Takashi, Uno Yota, Morikawa Mako, Ishizuka Kanako, Shiino Tomoko, Kimura Hiroki, Arioka Yuko, Yoshimi Akira, Takasaki Yuto, Yu Yanjie, Nakamura Yukako, Yamamoto Maeri, Iidaka Tetsuya, Iritani Shuji, Inada Toshiya, Ogawa Nanayo, Shishido Emiko, Torii Youta, Kawano Naoko, Omura Yutaka, Yoshikawa Toru, Uchiyama Tokio, Yamamoto Toshimichi, Ikeda Masashi, Hashimoto Ryota, Yamamori Hidenaga, Yasuda Yuka, Someya Toshiyuki, Watanabe Yuichiro, Egawa Jun, Nunokawa Ayako, Itokawa Masanari, Arai Makoto, Miyashita Mitsuhiro, Kobori Akiko, Suzuki Michio, Takahashi Tsutomu, Usami Masahide, Kodaira Masaki, Watanabe Kyota, Sasaki Tsukasa, Kuwabara Hitoshi, Tochigi Mamoru, Nishimura Fumichika, Yamasue Hidenori, Eriguchi Yosuke, Benner Seico, Kojima Masaki, Yassin Walid, Munesue Toshio, Yokoyama Shigeru, Kimura Ryo, Funabiki Yasuko, Kosaka Hirotaka, Ishitobi Makoto, Ohmori Tetsuro, Numata Shusuke, Yoshikawa Takeo, Toyota Tomoko, Yamakawa Kazuhiro, Suzuki Toshimitsu, Inoue Yushi, Nakaoka Kentaro, Goto Yu-ichi, Inagaki Masumi, Hashimoto Naoki, Kusumi Ichiro, Son Shuraku, Murai Toshiya, Ikegame Tempei, Okada Naohiro, Kasai Kiyoto, Kunimoto Shohko, Mori Daisuke, Iwata Nakao, Ozaki Norio

CELL REPORTS   Vol. 24 ( 11 ) page： 2838 - 2856   2018.9

Aberrant functional connectivity between the thalamus and visual cortex is related to attentional impairment in schizophrenia

Yamamoto, M; Kushima, I; Suzuki, R; Branko, A; Kawano, N; Inada, T; Iidaka, T; Ozaki, N

PSYCHIATRY RESEARCH-NEUROIMAGING   Vol. 278   page： 35 - 41   2018.8

Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia

Sobue Akira, Kushima Itaru, Nagai Taku, Shan Wei, Kohno Takao, Aleksic Branko, Aoyama Yuki, Mori Daisuke, Arioka Yuko, Kawano Naoko, Yamamoto Maeri, Hattori Mitsuharu, Nabeshima Toshitaka, Yamada Kiyofumi, Ozaki Norio

SCIENTIFIC REPORTS   Vol. 8   2018.8

Three lines of induced pluripotent stem cells derived from a 15q11.2-q13.1 duplication syndrome patient

Arioka Yuko, Kushima Itaru, Mori Daisuke, Ozaki Norio

STEM CELL RESEARCH   Vol. 31   page： 240 - 243   2018.8

Single-cell trajectory analysis of human homogenous neurons carrying a rare RELN variant

Arioka Yuko, Shishido Emiko, Kubo Hisako, Kushima Itaru, Yoshimi Akira, Kimura Hiroki, Ishizuka Kanako, Aleksic Branko, Maeda Takuji, Ishikawa Mitsuru, Kuzumaki Naoko, Okano Hideyuki, Mori Daisuke, Ozaki Norio

TRANSLATIONAL PSYCHIATRY   Vol. 8   2018.7

Induced pluripotent stem cells derived from a schizophrenia patient with ASTN2 deletion

Arioka Yuko, Kushima Itaru, Kubo Hisako, Mori Daisuke, Ozaki Norio

STEM CELL RESEARCH   Vol. 30   page： 81 - 84   2018.7

Induced pluripotent stem cells derived from a schizophrenia patient with ASTN2 deletion. Reviewed

Arioka Y, Kushima I, Kubo H, Mori D, Ozaki N.

Stem Cell Res.     2018.5

Integrative Analyses of De Novo Mutations Provide Deeper Biological Insights into Autism Spectrum Disorder

Takata Atsushi, Miyake Noriko, Tsurusaki Yoshinori, Fukai Ryoko, Miyatake Satoko, Koshimizu Eriko, Kushima Itaru, Okada Takashi, Morikawa Mako, Uno Yota, Ishizuka Kanako, Nakamura Kazuhiko, Tsujii Masatsugu, Yoshikawa Takeo, Toyota Tomoko, Okamoto Nobuhiko, Hiraki Yoko, Hashimoto Ryota, Yasuda Yuka, Saitoh Shinji, Ohashi Kei, Sakai Yasunari, Ohga Shouichi, Hara Toshiro, Kato Mitsuhiro, Nakamura Kazuyuki, Ito Aiko, Seiwa Chizuru, Shirahata Emi, Osaka Hitoshi, Matsumoto Ayumi, Takeshita Saoko, Tohyama Jun, Saikusa Tomoko, Matsuishi Toyojiro, Nakamura Takumi, Tsuboi Takashi, Kato Tadafumi, Suzuki Toshifumi, Saitsu Hirotomo, Nakashima Mitsuko, Mizuguchi Takeshi, Tanaka Fumiaki, Mori Norio, Ozaki Norio, Matsumoto Naomichi

CELL REPORTS   Vol. 22 ( 3 ) page： 734 - 747   2018.1

Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility

Yu Yanjie, Lin Yingni, Takasaki Yuto, Wang Chenyao, Kimura Hiroki, Xing Jingrui, Ishizuka Kanako, Toyama Miho, Kushima Itaru, Mori Daisuke, Arioka Yuko, Uno Yota, Shiino Tomoko, Nakamura Yukako, Okada Takashi, Morikawa Mako, Ikeda Masashi, Iwata Nakao, Okahisa Yuko, Takaki Manabu, Sakamoto Shinji, Someya Toshiyuki, Egawa Jun, Usami Masahide, Kodaira Masaki, Yoshimi Akira, Oya-Ito Tomoko, Aleksic Branko, Ohno Kinji, Ozaki Norio

TRANSLATIONAL PSYCHIATRY   Vol. 8   2018.1

IDENTIFICATION OF RARE DISRUPTIVE VARIANTS IN VOLTAGE-GATED CHANNEL GENES (CACNA1C, CACNA1D, CACNA1S, CACNA1I) IN JAPANESE SAMPLES OF SCHIZOPHRENIA AND AUTISM SPECTRUM DISORDER USING ION TORRENT PGM PLATFORM

Wang Chenyao, Kimura Hiroki, Xing Jingrui, Ishizuka Kanoko, Kushima Itaru, Arioka Yuko, Yoshimi Akira, Nakamura Yukako, Shiino Yomoko, Oya Yuko, Takasaki Yuto, Aleksic Branko, Mori Daisuke, Ozaki Norio

EUROPEAN NEUROPSYCHOPHARMACOLOGY   Vol. 27   page： S341 - S342   2017.10

MUTATION SCREENING OF THE PCDH15 GENE IN PATIENTS SUFFERING FROM AUTISM SPECTRUM DISORDERS AND SCHIZOPHRENIA

Ishizuka Kanako, Wang Chenyao, Kimura Hiroki, Xing Jingrui, Kushima Itaru, Arioka Yuko, Yoshimi Akira, Nakamura Yukako, Oya-Ito Tomoko, Takasaki Yuto, Uno Yota, Okada Takashi, Mori Daisuke, Aleksic Branko, Ozaki Norio

EUROPEAN NEUROPSYCHOPHARMACOLOGY   Vol. 27   page： S162 - S163   2017.10

Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder

Lim Elaine T., Uddin Mohammed, De Rubeis Silvia, Chan Yingleong, Kamumbu Anne S., Zhang Xiaochang, D'Gama Alissa M., Kim Sonia N., Hill Robert Sean, Goldberg Arthur P., Poultney Christopher, Minshew Nancy J., Kushima Itaru, Aleksic Branko, Ozaki Norio, Parellada Mara, Arango Celso, Penzol Maria J., Carracedo Angel, Kolevzon Alexander, Hultman Christina M., Weiss Lauren A., Fromer Menachem, Chiocchetti Andreas G., Freitag Christine M., Church George M., Scherer Stephen W., Buxbaum Joseph D., Walsh Christopher A.

NATURE NEUROSCIENCE   Vol. 20 ( 9 ) page： 1217 - +   2017.9

A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility

Kimura H., Fujita Y., Kawabata T., Ishizuka K., Wang C., Iwayama Y., Okahisa Y., Kushima I., Morikawa M., Uno Y., Okada T., Ikeda M., Inada T., Branko A., Mori D., Yoshikawa T., Iwata N., Nakamura H., Yamashita T., Ozaki N.

TRANSLATIONAL PSYCHIATRY   Vol. 7   2017.8

Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders

Ishizuka K., Fujita Y., Kawabata T., Kimura H., Iwayama Y., Inada T., Okahisa Y., Egawa J., Usami M., Kushima I., Uno Y., Okada T., Ikeda M., Aleksic B., Mori D., Someya To, Yoshikawa T., Iwata N., Nakamura H., Yamashita T., Ozaki N.

TRANSLATIONAL PSYCHIATRY   Vol. 7   2017.8

High-resolution copy number variation analysis of schizophrenia in Japan Reviewed

Kushima I, Aleksic B, Nakatochi M, Shimamura T, Shiino T, Yoshimi A, Kimura H, Takasaki Y, Wang C, Xing J, Ishizuka K, Oya-Ito T, Nakamura Y, Arioka Y, Maeda T, Yamamoto M, Yoshida M, Noma H, Hamada S, Morikawa M, Uno Y, Okada T, Iidaka T, Iritani S, Yamamoto T, Miyashita M, Kobori A, Arai M, Itokawa M, Cheng MC, Chuang YA, Chen CH, Suzuki M, Takahashi T, Hashimoto R, Yamamori H, Yasuda Y, Watanabe Y, Nunokawa A, Someya T, Ikeda M, Toyota T, Yoshikawa T, Numata S, Ohmori T, Kunimoto S, Mori D, Iwata N, Ozaki N.

Molecular Psychiatry   Vol. 22 ( 3 ) page： 430-440   2017.3

High-resolution copy number variation analysis of schizophrenia in Japan

Kushima, I; Aleksic, B; Nakatochi, M; Shimamura, T; Shiino, T; Yoshimi, A; Kimura, H; Takasaki, Y; Wang, C; Xing, J; Ishizuka, K; Oya-Ito, T; Nakamura, Y; Arioka, Y; Maeda, T; Yamamoto, M; Yoshida, M; Noma, H; Hamada, S; Morikawa, M; Uno, Y; Okada, T; Iidaka, T; Iritani, S; Yamamoto, T; Miyashita, M; Kobori, A; Arai, M; Itokawa, M; Cheng, MC; Chuang, YA; Chen, CH; Suzuki, M; Takahashi, T; Hashimoto, R; Yamamori, H; Yasuda, Y; Watanabe, Y; Nunokawa, A; Someya, T; Ikeda, M; Toyota, T; Yoshikawa, T; Numata, S; Ohmori, T; Kunimoto, S; Mori, D; Iwata, N; Ozaki, N

MOLECULAR PSYCHIATRY   Vol. 22 ( 3 ) page： 430 - 440   2017.3

Copy number variant in the region of adenosine kinase (ADK) and its possible contribution to schizophrenia susceptibility. Reviewed

Kimura H, Kushima I, Yohimi A, Aleksic B, Ozaki N.

Int J Neuropsychopharmacol.     2017

Possible involvement of a cell adhesion molecule, Migfilin, in brain development and pathogenesis of autism spectrum disorders. Reviewed

Ishizuka K, Tabata H, Ito H, Kushima I, Noda M, Yoshimi A, Usami M, Watanabe K, Morikawa M, Uno Y, Okada T, Mori D, Aleksic B, Ozaki N, Nagata KI.

J Neurosci Res.     2017

Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders. Reviewed

Isles AR, Ingason A, Lowther C, Walters J, Gawlick M, Stöber G, Rees E, Martin J, Little RB, Potter H, Georgieva L, Pizzo L, Ozaki N, Aleksic B, Kushima I, Ikeda M, Iwata N, Levinson DF, Gejman PV, Shi J, Sanders AR, Duan J, Willis J, Sisodiya S, Costain G, Werge TM, Degenhardt F, Giegling I, Rujescu D, Hreidarsson SJ, Saemundsen E, Ahn JW, Ogilvie C, Girirajan SD, Stefansson H, Stefansson K, O'Donovan MC, Owen MJ, Bassett A, Kirov G.

PLoS Genet.   Vol. 12 ( 5 ) page： e1005993   2016.5

Trends in big data analyses by multicenter collaborative translational research in psychiatry. Invited Reviewed

Psychiatry Clin Neurosci.     2022.1

Autism spectrum disorder comorbid with obsessive compulsive disorder and eating disorder in a woman with NBEA deletion. Reviewed

Psychiatry Clin Neurosci.     2022.1

Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial. Reviewed

Brain     2022

Psychiatric patients with a de novo 17q12 deletion: two case reports. Reviewed

Kushima I, Uematsu M, Ishizuka K, Aleksic B, Ozaki N.

Psychiatry Clin Neurosci.     2022

Identification of rare mutations of the vasoactive intestinal peptide receptor 2 gene in schizophrenia. Reviewed International coauthorship

Psychiatr Genet.     2022

Treatment-resistant schizophrenia in patients with 3q29 deletion: A case series of four patients. Reviewed

Nawa Y, Kushima I, Aleksic B, Yamamoto M, Kimura H, Banno M, Hashimoto R, Ozaki N.

Psychiatry Clin Neurosci.     2022

AKR1A1 Variant Associated With Schizophrenia Causes Exon Skipping, Leading to Loss of Enzymatic Activity. Reviewed

Front Genet.     2021.12

Brain capillary structures of schizophrenia cases and controls show a correlation with their neuron structures. Reviewed

Sci Rep.     2021.6

Dysregulation of post-transcriptional modification by copy number variable microRNAs in schizophrenia with enhanced glycation stress. Reviewed

Transl Psychiatry     2021.5

Two novel mouse models mimicking minor deletions in 22q11.2 deletion syndrome revealed the contribution of each deleted region to psychiatric disorders. Reviewed

Mol Brain.     2021.4

Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial. Reviewed

Yamasue H, Okada T, Munesue T, Kuroda M, Fujioka T, Uno Y, Matsumoto K, Kuwabara H, Mori D, Okamoto Y, Yoshimura Y, Kawakubo Y, Arioka Y, Kojima M, Yuhi T, Owada K, Yassin W, Kushima I, Benner S, Ogawa N, Eriguchi Y, Kawano N, Uemura Y, Yamamoto M, Kano Y, Kasai K, Higashida H, Ozaki N, Kosaka H.

Mol Psychiatry.     2018.6

Aberrant functional connectivity between the thalamus and visual cortex is related to attentional impairment in schizophrenia. Reviewed

Yamamoto M, Kushima I, Suzuki R, Branko A, Kawano N, Inada T, Iidaka T, Ozaki N.

Psychiatry Res Neuroimaging.     2018.6

Single-neuron and genetic correlates of autistic behavior in macaque. Reviewed

Yoshida K, Go Y, Kushima I, Toyoda A, Fujiyama A, Imai H, Saito N, Iriki A, Ozaki N, Isoda M.

Sci Adv.   Vol. 2 ( 9 ) page： e1600558   2016.9

ゲノム情報を起点とした精神疾患の病態研究と人工知能の活用

久島周（ Role： Contributor）

臨床精神薬理  2023.2 

重症の摂食障害におけるゲノムコピー数バリアントの寄与

久島周（ Role： Contributor）

精神神経学雑誌  2023 

精神医学・遺伝学における症例報告の意義と倫理

久島周（ Role： Joint author）

臨床精神医学  2022.2 

自閉スペクトラム症の発症に関わる ゲノムバリアント

（ Role： Joint author）

CLINICAL NEUROSCIENCE  2022 

精神科臨床 Legato ARHGAP10遺伝子変異と統合失調症発症の関連

（ Role： Joint author）

メディカルレビュー社  2021.3 

統合失調症の発症と自閉スペクトラム症とのオーバーラップ

久島周（ Role： Joint author）

先端医学社  2021.3 

「精神医学における科学的基盤」　ゲノムと精神医学―精神疾患のゲノム基盤と遺伝環境相互作用解明はどのようにして精神医学にイノベーションをもたらすか

学樹書院  2020.1 

細胞　稀なバリアントに着目した精神疾患のゲノム研究

ニューサイエンス社  2019.12 

分子精神医学　ヒトゲノムコピー数変異（CNV）

岩田仲生他（ Role： Joint author）

先端医学社  2015.4 

図説　分子病態学　第5版　精神疾患：統合失調症と双極性障害

一瀬白帝他（ Role： Joint author）

中外医学社  2014.1 

ファインケミカル　精神障害のゲノム研究

糸川昌成他（ Role： Joint author）

シーエムシー出版  2012.7 

BRAIN and NERVE　発達期精神障害─発達障害を中心に

笠井清登他（ Role： Joint author）

医学書院  2012 

精神医学キーワード辞典　うつ病の遺伝子・環境相関仮説

松下正明他（ Role： Joint author）

中山書店  2011.7 

精神医学領域の論文を読みこなすキーワード100　ゲノムコピー数変異

新興医学出版社 

精神疾患横断的に発症に関与するゲノムコピー数変異 統合失調症と自閉スペクトラム症に着目して

久島周

第43回日本生物学的精神医学会 

統合失調症のゲノム解析と診断法・治療薬開発への展開

久島周

第43回日本生物学的精神医学会  2021.7.14 

精神疾患横断的に発症に関与するゲノムコピー数変異統合失調症と自閉スペクトラム症に着目して

日本人類遺伝学会 第65回大会  2020.11.18  日本人類遺伝学会

統合失調症のゲノムコピー数変異（CNV）解析

久島周他

第10回日本統合失調症学会若手シンポジウム 

統合失調症のゲノムコピー数変異（CNV）解析

久島周他

第３回霊長類認知ゲノミクスワークショップ 

臨床と遺伝子像　自閉スペクトラム症（ASD）の遺伝子解析から　最近わかってきたこと

久島周他

第4回日本情動学会　シンポジウム