2024/04/03 更新

写真a

ヤマムラ タケシ
山村 健史
YAMAMURA Takeshi
所属
医学部附属病院 消化器内科 病院講師
職名
病院講師

学位 1

  1. 医学博士 ( 2014年1月   名古屋大学 ) 

研究分野 1

  1. その他 / その他  / 小腸・大腸

学歴 1

  1. 名古屋大学   医学部

    - 2002年3月

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    国名: 日本国

所属学協会 5

  1. 日本消化器病学会   専門医・指導医・支部評議員・学会評議員

  2. 日本消化器内視鏡学会   専門医・指導医・支部評議員・学会評議員

  3. 日本内科学会   認定医・専門医・指導医

  4. 日本消化管学会   専門医,指導医

  5. 日本カプセル内視鏡学会   認定医・代議員

 

論文 200

  1. Artificial intelligence-based diagnostic imaging system with virtual enteroscopy and virtual unfolded views to evaluate small bowel lesions in Crohn's disease.

    Furukawa K, Oda M, Watanabe O, Nakamura M, Yamamura T, Maeda K, Mori K, Kawashima H

    Revista espanola de enfermedades digestivas     2024年3月

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    記述言語:英語  

    DOI: 10.17235/reed.2024.10405/2024

    PubMed

  2. Efficacy of endoscopic submucosal resection with a ligation device for small rectal neuroendocrine tumor: study protocol of a multicenter open-label randomized control trial (BANDIT trial)

    Takada, K; Imai, K; Yamada, T; Ohata, K; Kanesaka, T; Nagami, Y; Yamasaki, Y; Kobara, H; Inokuchi, Y; Chino, A; Yamaguchi, S; Ikehara, H; Kawamura, T; Yabuuchi, Y; Mizuguchi, Y; Ikematsu, H; Yokoi, C; Hattori, S; Ohno, K; Yoshizawa, Y; Fukuzawa, M; Tsuji, Y; Konishi, J; Yamamura, T; Osawa, S; Oka, S; Hikichi, T; Togashi, K; Hirasawa, K; Uraoka, T; Takeuchi, Y; Chiba, H; Komeda, Y; Doyama, H; Oba, MS; Saito, Y

    BMC GASTROENTEROLOGY   24 巻 ( 1 ) 頁: 69   2024年2月

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  3. Risk factors for rebleeding in gastroduodenal ulcers

    Ito, N; Funasaka, K; Fujiyoshi, T; Nishida, K; Satta, Y; Furukawa, K; Kakushima, N; Furune, S; Ishikawa, E; Mizutani, Y; Sawada, T; Maeda, K; Ishikawa, T; Yamamura, T; Ohno, E; Nakamura, M; Miyahara, R; Sasaki, Y; Haruta, JI; Fujishiro, M; Kawashima, H

    IRISH JOURNAL OF MEDICAL SCIENCE   193 巻 ( 1 ) 頁: 173 - 179   2024年2月

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  4. An Analysis of Delayed Bleeding in Cases of Colorectal Endoscopic Submucosal Dissection Due to Types of Direct Oral Anticoagulants in Japan

    Yoshida, N; Hayashi, Y; Togo, D; Oka, S; Takada, K; Fukunaga, S; Morita, Y; Hayashi, T; Kozuka, K; Tsuji, Y; Murakami, T; Yamamura, T; Komeda, Y; Takeuchi, Y; Shinmura, K; Fukuda, H; Yoshii, S; Ono, S; Katsuki, S; Kawashima, K; Nemoto, D; Yamamoto, H; Saito, Y; Tamai, N; Iwao, A; Itoi, Y; Tsuji, S; Inagaki, Y; Inada, Y; Soga, K; Hasegawa, D; Murakami, T; Yoriki, H; Fukumoto, K; Motoyoshi, T; Nakatani, Y; Sano, Y; Iguchi, M; Fujii, S; Ban, HRMT; Harada, K; Okamoto, K; Nishiyama, H; Sasaki, F; Mizukami, K; Shono, T; Shimoda, R; Miike, T; Yamaguchi, N

    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY   22 巻 ( 2 ) 頁: 271 - 282.e3   2024年2月

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  5. Monoclonal Antibody Against Mature Interleukin-18 Ameliorates Colitis in Mice and Improves Epithelial Barrier Function

    Ikegami, S; Maeda, K; Urano, T; Mu, JX; Nakamura, M; Yamamura, T; Sawada, T; Ishikawa, E; Yamamoto, K; Muto, H; Oishi, A; Iida, T; Mizutani, Y; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Honda, T; Ishigami, M; Kawashima, H

    INFLAMMATORY BOWEL DISEASES     2023年12月

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    記述言語:英語  

    DOI: 10.1093/ibd/izad292

    Web of Science

    PubMed

  6. Association of direct oral anticoagulant and delayed bleeding with pharmacokinetics after endoscopic submucosal dissection.

    Murata M, Sugimoto M, Ueshima S, Nagami Y, Ominami M, Sawaya M, Nakatani Y, Furumoto Y, Dohi O, Sumiyoshi T, Fukuzawa M, Tsuji S, Miyahara K, Takeuchi Y, Suzuki S, Tominaga N, Yagi N, Osawa S, Sakata Y, Yamada T, Yoshizawa Y, Yamauchi A, Yamamura T, Orihara S, Miyamoto S, Matsuda S, Hira D, Terada T, Katsura T, Gotoda T, Fujishiro M, Kawai T

    Gastrointestinal endoscopy     2023年12月

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    記述言語:英語  

    DOI: 10.1016/j.gie.2023.11.048

    PubMed

  7. Current status of and future issues related to endoscopic papillectomy

    Kawashima, H; Ishikawa, T; Yamao, K; Mizutani, Y; Iida, T; Uetsuki, K; Yamamura, T; Furukawa, K; Nakamura, M

    NAGOYA JOURNAL OF MEDICAL SCIENCE   85 巻 ( 4 ) 頁: 648 - 658   2023年11月

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  8. Real-World Effectiveness and Risk Factors for Discontinuation of Ustekinumab in Ulcerative Colitis.

    Uchida G, Nakamura M, Yamamura T, Maeda K, Sawada T, Ishikawa E, Furukawa K, Iida T, Mizutani Y, Yamao K, Ishikawa T, Ishizu Y, Honda T, Ishigami M, Kawashima H

    Inflammatory intestinal diseases   8 巻 ( 2 ) 頁: 60 - 68   2023年10月

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    記述言語:英語  

    DOI: 10.1159/000531497

    PubMed

  9. Multicenter prospective registration study of efficacy and safety of capsule endoscopy in Crohn's disease in Japan (SPREAD-J study)

    Sakurai, T; Omori, T; Tanaka, H; Ito, T; Ando, K; Yamamura, T; Nanjjo, S; Osawa, S; Takeda, T; Watanabe, K; Hiraga, H; Yamamoto, S; Ozeki, K; Tanaka, S; Tajiri, H; Saruta, M; SPREAD J Grp

    JOURNAL OF GASTROENTEROLOGY   58 巻 ( 10 ) 頁: 1003 - 1014   2023年10月

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  10. Randomized trial comparing 15 <i>vs</i> 5 actuations per pass during endoscopic ultrasound-guided fine-needle biopsy for specimen acquisition of solid pancreatic lesions

    Kataoka, K; Ishikawa, T; Ohno, E; Yamao, K; Mizutani, Y; Iida, T; Kato, K; Kinoshita, F; Yamamura, T; Furukawa, K; Nakamura, M; Kawashima, H

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   38 巻 ( 9 ) 頁: 1647 - 1655   2023年9月

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    記述言語:英語  

    DOI: 10.1111/jgh.16258

    Web of Science

    PubMed

  11. Clinical characteristics of Dieulafoy's lesion in the small bowel diagnosed and treated by double-balloon endoscopy

    Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Ishikawa, E; Furukawa, K; Iida, T; Mizutani, Y; Yamao, K; Ishikawa, T; Honda, T; Ishigami, M; Kawashima, H

    BMC GASTROENTEROLOGY   23 巻 ( 1 ) 頁: 290   2023年8月

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  12. Real-world effectiveness of ustekinumab for patients with ulcerative colitis: a systematic review and meta-analysis

    Uchida, G; Nakamura, M; Yamamura, T; Tsuzuki, T; Kawashima, H

    NAGOYA JOURNAL OF MEDICAL SCIENCE   85 巻 ( 3 ) 頁: 402 - 427   2023年8月

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  13. Systematic Review and Meta-Analysis of the Use of Serum Leucine-Rich Alpha-2 Glycoprotein to Assess Crohn's Disease Activity

    Okita, M; Nakashima, K; Yamamura, T; Matsui, S

    INFLAMMATORY BOWEL DISEASES     2023年7月

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    記述言語:英語  

    DOI: 10.1093/ibd/izad128

    Web of Science

    PubMed

  14. Efficacy of 1-kestose supplementation in patients with mild to moderate ulcerative colitis: A randomised, double-blind, placebo-controlled pilot study 国際誌

    Ikegami, S; Nakamura, M; Honda, T; Yamamura, T; Maeda, K; Sawada, T; Ishikawa, E; Yamamoto, K; Furune, S; Ishikawa, T; Furukawa, K; Ohno, E; Ishigami, M; Kinoshita, F; Kadota, Y; Tochio, T; Shimomura, Y; Hirooka, Y; Kawashima, H

    ALIMENTARY PHARMACOLOGY & THERAPEUTICS   57 巻 ( 11 ) 頁: 1249 - 1257   2023年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/apt.17387

    Web of Science

    PubMed

  15. Management of colorectal high-grade dysplasia or cancer resected by cold snare polypectomy: a multicenter exploratory study

    Inoki, K; Takamaru, H; Furuhashi, H; Kishida, Y; Shimodate, Y; Sumida, Y; Hosotani, K; Ueyama, H; Furumoto, Y; Hashimoto, S; Takeuchi, Y; Ichijima, R; Yoshizawa, Y; Suzuki, T; Minoda, Y; Mizukami, K; Matsumura, T; Kasai, T; Yamamura, T; Ohnita, K; Hara, K; Esaki, M; Katagiri, A; Ishikawa, H; Gotoda, T

    JOURNAL OF GASTROENTEROLOGY   58 巻 ( 6 ) 頁: 554 - 564   2023年6月

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  16. Linked-Color Imaging Detects More Colorectal Adenoma and Serrated Lesions: An International Randomized Controlled Trial

    Suzuki, S; Aniwan, S; Chiu, HM; Laohavichitra, K; Chirapongsathorn, S; Yamamura, T; Kuo, CY; Yoshida, N; Ang, TL; Takezawa, T; Rerknimitr, R; Ishikawa, H; Gotoda, T

    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY   21 巻 ( 6 ) 頁: 1493 - +   2023年6月

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  17. ENDOSCOPIC TREATMENT OF DUODENAL NEUROENDOCRINE TUMORS

    Furukawa, K; Furune, S; Ishikawa, E; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Nakamura, M; Kawashima, H

    GASTROINTESTINAL ENDOSCOPY   97 巻 ( 6 ) 頁: AB1211 - AB1212   2023年6月

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  18. COMPARISON OF COLON ADENOMA DETECTION RATE USING TRANSPARENT CAP-ASSISTED AND CONVENTIONAL COLONOSCOPY: RESULT FROM A CONSORTIUM OF INTERNATIONAL TERTIARY-CARE ENDOSCOPY CENTERS IN ASIA

    Chirapongsathorn, S; Prasanwon, P; Suzuki, S; Aniwan, S; Chen, YN; Chantarojanasiri, T; Yamamura, T; Kuo, CY; Yoshida, N; Ang, TL; Takezawa, T; Ishikawa, H; Gotoda, T

    GASTROINTESTINAL ENDOSCOPY   97 巻 ( 6 ) 頁: AB135 - AB135   2023年6月

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  19. COMPARISON OF COLON ADENOMA DETECTION RATE USING TRANSPARENT CAP-ASSISTED AND CONVENTIONAL COLONOSCOPY: RESULT FROM A CONSORTIUM OF INTERNATIONAL TERTIARY-CARE ENDOSCOPY CENTERS IN ASIA

    Chirapongsathorn, S; Prasanwon, P; Suzuki, S; Aniwan, S; Chen, YN; Chantarojanasiri, T; Yamamura, T; Kuo, CY; Yoshida, N; Ang, TL; Takezawa, T; Ishikawa, H; Gotoda, T

    GASTROINTESTINAL ENDOSCOPY   97 巻 ( 6 ) 頁: AB237 - AB237   2023年6月

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  20. Diagnostic Performance of Endocytoscopy for Esophageal Eosinophilia

    Hida, E; Muroi, K; Kakushima, N; Furune, S; Ishikawa, E; Mizutani, Y; Sawada, T; Keiko, M; Yamamura, T; Ishikawa, T; Furukawa, K; Ohno, E; Nakamura, M; Nishida, K; Fujishiro, M; Kawashima, H

    DIGESTION   104 巻 ( 3 ) 頁: 202 - 211   2023年6月

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    記述言語:英語  

    DOI: 10.1159/000528174

    Web of Science

    PubMed

  21. CO<sub>2</sub> enterography in endoscopic retrograde cholangiography using double-balloon endoscopy: A randomized clinical trial

    Murate, K; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Ishikawa, E; Kida, Y; Esaki, M; Hamazaki, M; Iida, T; Mizutani, Y; Yamao, K; Ishikawa, T; Furukawa, K; Ohno, E; Honda, T; Ishigami, M; Kinoshita, F; Ando, M; Kawashima, H

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   38 巻 ( 5 ) 頁: 761 - 767   2023年5月

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    記述言語:英語  

    DOI: 10.1111/jgh.16112

    Web of Science

    PubMed

  22. Novel endoscopic approaches using the endocytoscopy for the target biopsy in esophageal eosinophilia

    Muroi, K; Kakushima, N; Furukawa, K; Furune, S; Ito, N; Hirose, T; Hida, E; Suzuki, T; Suzuki, T; Hirai, K; Shibata, H; Ishikawa, E; Sawada, T; Maeda, K; Yamamura, T; Ohno, E; Nakamura, M; Fujishiro, M; Kawashima, H

    ESOPHAGUS   20 巻 ( 2 ) 頁: 325 - 332   2023年4月

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  23. Accuracy of Serum Leucine-Rich Alpha-2 Glycoprotein in Evaluating Endoscopic Disease Activity in Crohn's Disease 査読有り 国際誌

    Kawamura, T; Yamamura, T; Nakamura, M; Maeda, K; Sawada, T; Ishikawa, E; Iida, T; Mizutani, Y; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Honda, T; Kawashima, H; Ishigami, M

    INFLAMMATORY BOWEL DISEASES   29 巻 ( 2 ) 頁: 245 - 253   2023年2月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/ibd/izac076

    Web of Science

    PubMed

  24. Factors Related to Delayed Adverse Events of Endoscopic Submucosal Dissection in the Duodenum

    Kawamura, T; Hirose, T; Kakushima, N; Furukawa, K; Furune, S; Ishikawa, E; Sawada, T; Keiko, M; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Honda, T; Ishigami, M; Kawashima, H; Fujishiro, M

    DIGESTIVE DISEASES   41 巻 ( 1 ) 頁: 80 - 88   2023年1月

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    記述言語:英語  

    DOI: 10.1159/000522362

    Web of Science

    PubMed

  25. Current status of transanal total mesorectal excision for rectal cancer and the expanding indications of the transanal approach for extended pelvic surgeries

    Uehara, K; Ogura, A; Murata, Y; Sando, M; Mukai, T; Aiba, T; Yamamura, T; Nakamura, M

    DIGESTIVE ENDOSCOPY   35 巻 ( 2 ) 頁: 243 - 254   2023年1月

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    記述言語:英語  

    DOI: 10.1111/den.14464

    Web of Science

    PubMed

  26. Network Analysis of Gut Microbiota Including <i>Fusobacterium</i> and Oral Origin Bacteria and Their Distribution on Tumor Surface, Normal Mucosa, and in Feces in Patients with Colorectal Cancer

    Ohashi, A; Yamamura, T; Nakamura, M; Maeda, K; Sawada, T; Ishikawa, E; Yamamoto, K; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Honda, T; Kawashima, H; Ishigami, M; Fujishiro, M

    DIGESTION   103 巻 ( 6 ) 頁: 451 - 461   2022年12月

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    記述言語:英語  

    DOI: 10.1159/000527170

    Web of Science

    PubMed

  27. The effects of ustekinumab on small intestinal lesions and stenotic lesions

    Wada, H; Murate, K; Nakamura, M; Furukawa, K; Kakushima, N; Yamamura, T; Maeda, K; Sawada, T; Ishikawa, E; Ishikawa, T; Ohno, E; Honda, T; Kawashima, H; Nakayama, G; Hattori, N; Umeda, S; Ishigami, M

    NAGOYA JOURNAL OF MEDICAL SCIENCE   84 巻 ( 4 ) 頁: 825 - 838   2022年11月

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  28. Analysis of immunologic comorbidities in ulcerative colitis patients: a tool to prevent exacerbations in ulcerative colitis cases

    Meza, MRR; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Ishikawa, E; Kakushima, N; Furukawa, K; Iida, T; Mizutani, Y; Ishikawa, T; Ohno, E; Honda, T; Kawashima, H; Ishigami, M

    NAGOYA JOURNAL OF MEDICAL SCIENCE   84 巻 ( 4 ) 頁: 733 - 745   2022年11月

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  29. The role of EUS elastography-guided fine needle biopsy in the histological diagnosis of solid pancreatic lesions: a prospective exploratory study

    Ohno, E; Kawashima, H; Ishikawa, T; Mizutani, Y; Iida, T; Nishio, R; Uetsuki, K; Yashika, J; Yamada, K; Yoshikawa, M; Gibo, N; Aoki, T; Kataoka, K; Mori, H; Takada, Y; Aoi, H; Takahashi, H; Yamamura, T; Furukawa, K; Nakamura, M; Shimoyama, Y; Hirooka, Y; Fujishiro, M

    SCIENTIFIC REPORTS   12 巻 ( 1 ) 頁: 16603   2022年10月

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  30. Modified N score is helpful for identifying patients who need endoscopic intervention among those with black stools without hematemesis

    Ito, N; Funasaka, K; Fujiyoshi, T; Furukawa, K; Kakushima, N; Furune, S; Ishikawa, E; Mizutani, Y; Sawada, T; Maeda, K; Ishikawa, T; Yamamura, T; Ohno, E; Nakamura, M; Kawashima, H; Miyahara, R; Hirooka, Y; Haruta, JI; Fujishiro, M

    DIGESTIVE ENDOSCOPY   34 巻 ( 6 ) 頁: 1157 - 1165   2022年9月

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    記述言語:英語  

    DOI: 10.1111/den.14323

    Web of Science

    PubMed

  31. Examination of Abnormal Alpha-synuclein Aggregates in the Enteric Neural Plexus in Patients with Ulcerative Colitis

    Gibo, N; Hamaguchi, T; Miki, Y; Yamamura, T; Nakaguro, M; Ito, M; Nakamura, M; Kawashima, H; Hirayama, M; Hirooka, Y; Wakabayashi, K; Ohno, K

    JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES   31 巻 ( 3 ) 頁: 290 - 300   2022年9月

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    記述言語:英語  

    DOI: 10.15403/jgld-4313

    Web of Science

    PubMed

  32. Endoscopic management of perihilar cholangiocarcinoma

    Kawashima, H; Ohno, E; Ishikawa, T; Mizutani, Y; Iida, T; Yamamura, T; Kakushima, N; Furukawa, K; Nakamura, M

    DIGESTIVE ENDOSCOPY   34 巻 ( 6 ) 頁: 1147 - 1156   2022年9月

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    記述言語:英語  

    DOI: 10.1111/den.14317

    Web of Science

    PubMed

  33. Fecal microbiota transplantation in the treatment of irritable bowel syndrome: a single-center prospective study in Japan

    Hamazaki, M; Sawada, T; Yamamura, T; Maeda, K; Mizutani, Y; Ishikawa, E; Furune, S; Yamamoto, K; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Honda, T; Kawashima, H; Ishigami, M; Nakamura, M; Fujishiro, M

    BMC GASTROENTEROLOGY   22 巻 ( 1 ) 頁: 342   2022年7月

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  34. Endoscopic sphincterotomy and endoscopic biliary stenting do not affect the sensitivity of transpapillary forceps biopsy for the diagnosis of bile duct adenocarcinoma

    Aoki, T; Ohno, E; Ishikawa, T; Mizutani, Y; Iida, T; Yamao, K; Yamamura, T; Furukawa, K; Nakamura, M; Honda, T; Ishigami, M; Yatsuya, H; Kawashima, H

    BMC GASTROENTEROLOGY   22 巻 ( 1 ) 頁: 329   2022年7月

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  35. Effects of steroid use for stenosis prevention after endoscopic submucosal dissection for cervical esophageal cancer

    Muroi, K; Kakushima, N; Furukawa, K; Furune, S; Ito, N; Hirose, T; Ishikawa, E; Mizutani, Y; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Funasaka, K; Miyahara, R; Fujishiro, M

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   27 巻 ( 5 ) 頁: 940 - 947   2022年5月

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  36. Relationship between psoas muscle index and long-term survival in older patients aged ≥ 80 years after endoscopic submucosal dissection for gastric cancer

    Ito, N; Funasaka, K; Miyahara, R; Furukawa, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Hirooka, Y; Fujishiro, M

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   27 巻 ( 4 ) 頁: 729 - 738   2022年4月

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  37. Gelsolin as a Potential Biomarker for Endoscopic Activity and Mucosal Healing in Ulcerative Colitis

    Maeda, K; Nakamura, M; Yamamura, T; Sawada, T; Ishikawa, E; Oishi, A; Ikegami, S; Kakushima, N; Furukawa, K; Iida, T; Mizutani, Y; Ishikawa, T; Ohno, E; Honda, T; Ishigami, M; Kawashima, H

    BIOMEDICINES   10 巻 ( 4 )   2022年4月

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  38. Diagnostic performance of endoscopic classifications for neoplastic lesions in patients with ulcerative colitis: A retrospective case-control study

    Kida, Y; Yamamura, T; Maeda, K; Sawada, T; Ishikawa, E; Mizutani, Y; Kakushima, N; Furukawa, K; Ishikawa, T; Ohno, E; Kawashima, H; Nakamura, M; Ishigami, M; Fujishiro, M

    WORLD JOURNAL OF GASTROENTEROLOGY   28 巻 ( 10 ) 頁: 1055 - 1066   2022年3月

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  39. The impact of the age-adjusted Charlson comorbidity index as a prognostic factor for endoscopic papillectomy in ampullary tumors

    Takada, Y; Kawashima, H; Ohno, E; Ishikawa, T; Mizutani, Y; Iida, T; Yamamura, T; Kakushima, N; Furukawa, K; Nakamura, M; Honda, T; Ishigami, M; Ito, A; Hirooka, Y

    JOURNAL OF GASTROENTEROLOGY   57 巻 ( 3 ) 頁: 199 - 207   2022年3月

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  40. Fecal incontinence and oral regurgitation during duodenal endoscopic submucosal dissection using the water pressure method

    Takada, Y; Hirose, T; Nishida, K; Kakushima, N; Furukawa, K; Furune, S; Ishikawa, E; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Honda, T; Ishigami, M; Kawashima, H; Fujishiro, M

    DIGESTIVE ENDOSCOPY   34 巻 ( 3 ) 頁: 526 - 534   2022年3月

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    記述言語:英語  

    DOI: 10.1111/den.14070

    Web of Science

    PubMed

  41. Artificial intelligence-based diagnosis of upper gastrointestinal subepithelial lesions on endoscopic ultrasonography images

    Hirai, K; Kuwahara, T; Furukawa, K; Kakushima, N; Furune, S; Yamamoto, H; Marukawa, T; Asai, H; Matsui, K; Sasaki, Y; Sakai, D; Yamada, K; Nishikawa, T; Hayashi, D; Obayashi, T; Komiyama, T; Ishikawa, E; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Ishigami, M; Fujishiro, M

    GASTRIC CANCER   25 巻 ( 2 ) 頁: 382 - 391   2022年3月

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  42. A novel scoring system to predict therapeutic intervention for non-variceal upper gastrointestinal bleeding

    Ito, N; Funasaka, K; Furukawa, K; Kakushima, N; Hirose, T; Muroi, K; Suzuki, T; Suzuki, T; Hida, E; Ishikawa, T; Yamamura, T; Ohno, E; Nakamura, M; Kawashima, H; Miyahara, R; Fujishiro, M

    INTERNAL AND EMERGENCY MEDICINE   17 巻 ( 2 ) 頁: 423 - 430   2022年3月

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  43. Initial experience of tofacitinib for treating refractory moderate-to-severe ulcerative colitis

    Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, E; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Kawashima, H; Honda, T; Ishigami, M; Fujishiro, M

    NAGOYA JOURNAL OF MEDICAL SCIENCE   84 巻 ( 1 ) 頁: 169 - 179   2022年2月

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  44. Gastrointestinal: Idiopathic omental hemorrhage

    Furukawa, K; Yamamura, T; Nakamura, M; Kawashima, H; Fujishiro, M

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   37 巻 ( 2 ) 頁: 282 - 282   2022年2月

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    記述言語:英語  

    DOI: 10.1111/jgh.15639

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  45. Usefulness of Macroscopic On-Site Evaluation Using a Stereomicroscope during EUS-FNB for Diagnosing Solid Pancreatic Lesions

    Ishikawa, T; Ohno, E; Mizutani, Y; Iida, T; Uetsuki, K; Yashika, J; Yamada, K; Gibo, N; Aoki, T; Kataoka, K; Mori, H; Takada, Y; Takahashi, H; Aoi, H; Kato, K; Yamamura, T; Kakushima, N; Furukawa, K; Nakamura, M; Hirooka, Y; Kawashima, H

    CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   2022 巻   頁: 2737578   2022年1月

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  46. Evaluation of ulcerative colitis activity using transabdominal ultrasound shear wave elastography

    Yamada, K; Ishikawa, T; Kawashima, H; Ohno, E; Iida, T; Ishikawa, E; Mizutani, Y; Sawada, T; Maeda, K; Yamamura, T; Kakushima, N; Furukawa, K; Nakamura, M; Ishigami, M; Fujishiro, M

    QUANTITATIVE IMAGING IN MEDICINE AND SURGERY   12 巻 ( 1 ) 頁: 618 - 626   2022年1月

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  47. Preliminary Comparison of Endoscopic Brush and Net Catheters as the Sampling Tool to Analyze the Intestinal Mucus in the Rectum with Ulcerative Colitis Patients

    Nakamura, M; Maeda, K; Yamamoto, K; Yamamura, T; Sawada, T; Ishikawa, E; Kakushima, N; Furukawa, K; Iida, T; Mizutani, Y; Ishikawa, T; Ohno, E; Honda, T; Ishigami, M; Kawashima, H

    DIGESTION   103 巻 ( 3 ) 頁: 232 - 243   2022年

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    記述言語:英語  

    DOI: 10.1159/000521929

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  48. Immunoproliferative Small Intestinal Disease Diagnosed by Double-balloon Endoscopy with Biopsy Sampling

    Meza, MRR; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Ishikawa, E; Kakushima, N; Furukawa, K; Ohno, E; Honda, T; Kawashima, H; Ishigami, M

    INTERNAL MEDICINE   61 巻 ( 17 ) 頁: 2593 - 2599   2022年

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  49. Comparison of Endoscopic Ultrasonography and Conventional Endoscopy for Prediction of Tumor Depth in Superficial Nonampullary Duodenal Epithelial Tumors

    Matsuda, N; Hirose, T; Kakushima, N; Furukawa, K; Furune, S; Ishikawa, E; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Honda, T; Ishigami, M; Kawashima, H; Fujishiro, M

    DIGESTION   103 巻 ( 4 ) 頁: 319 - 328   2022年

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    記述言語:英語  

    DOI: 10.1159/000524841

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  50. Real-world local recurrence rate after cold polypectomy in colorectal polyps less than 10 mm using propensity score matching

    Saito, M; Yamamura, T; Nakamura, M; Maeda, K; Sawada, T; Ishikawa, E; Mizutani, Y; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Kawashima, H; Ishigami, M; Fujishiro, M

    WORLD JOURNAL OF GASTROENTEROLOGY   27 巻 ( 47 ) 頁: 8182 - 8193   2021年12月

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  51. Clinical characteristics of gastrointestinal immune-related adverse events of immune checkpoint inhibitors and their association with survival

    Yamada, K; Sawada, T; Nakamura, M; Yamamura, T; Maeda, K; Ishikawa, E; Iida, T; Mizutani, Y; Kakushima, N; Ishikawa, T; Furukawa, K; Ohno, E; Honda, T; Kawashima, H; Ishigami, M; Furune, S; Hase, T; Yokota, K; Maeda, O; Hashimoto, N; Akiyama, M; Ando, Y; Fujishiro, M

    WORLD JOURNAL OF GASTROENTEROLOGY   27 巻 ( 41 ) 頁: 7190 - 7206   2021年11月

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  52. Endocytoscopy Is Useful for the Diagnosis of Superficial Nonampullary Duodenal Epithelial Tumors

    Hirose, T; Kakushima, N; Furukawa, K; Furune, S; Ishikawa, E; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Nishida, K; Yokoi, T; Kawashima, H; Fujishiro, M

    DIGESTION   102 巻 ( 6 ) 頁: 895 - 902   2021年11月

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    記述言語:英語  

    DOI: 10.1159/000516512

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  53. Usefulness of functional splicing analysis to confirm precise disease pathogenesis in Diamond-Blackfan anemia caused by intronic variants in RPS19

    Takafuji Satoru, Mori Takeshi, Nishimura Noriyuki, Yamamoto Nobuyuki, Uemura Suguru, Nozu Kandai, Terui Kiminori, Toki Tsutomu, Ito Etsuro, Muramatsu Hideki, Takahashi Yoshiyuki, Matsuo Masafumi, Yamamura Tomohiko, Iijima Kazumoto

    PEDIATRIC HEMATOLOGY AND ONCOLOGY   38 巻 ( 6 ) 頁: 515 - 527   2021年9月

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    記述言語:日本語  

    DOI: 10.1080/08880018.2021.1887984

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  54. The role of early video capsule endoscopy in the diagnosis and prognosis of obscure gastrointestinal bleeding: A multi-center propensity score matching study

    Zhao, R; Nakamura, M; Wu, S; Uchida, G; Yamamura, T; Gao, YJ; Goto, H; Fujishiro, M; Ge, ZZ

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   36 巻 ( 9 ) 頁: 2540 - 2548   2021年9月

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    記述言語:英語  

    DOI: 10.1111/jgh.15491

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  55. Endoscopic Ultrasound Elastography as a Novel Diagnostic Method for the Assessment of Hardness and Depth of Invasion in Colorectal Neoplasms

    Esaki, M; Yamamura, T; Nakamura, M; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, E; Suzuki, H; Kuno, T; Yamada, K; Hasegawa, I; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Kawashima, H; Hirooka, Y; Fujishiro, M

    DIGESTION   102 巻 ( 5 ) 頁: 701 - 713   2021年9月

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    記述言語:英語  

    DOI: 10.1159/000511589

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  56. Feasibility of patency capsule and colon capsule endoscopy in patients with suspected gastrointestinal stenosis: a prospective study

    Otsuka, H; Nakamura, M; Yamamura, T; Maeda, K; Sawade, T; Mizutani, Y; Ishikawa, E; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Kawashima, I; Honda, T; Ishigami, M; Fujishiro, M

    NAGOYA JOURNAL OF MEDICAL SCIENCE   83 巻 ( 3 ) 頁: 419 - 430   2021年8月

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  57. Difference of efficacy for small bowel lesion in Crohn

    Sawada, T; Nakamura, M; Yamamura, T; Maeda, K; Ishikawa, E; Fujishiro, M

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   36 巻   頁: 116 - 116   2021年8月

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  58. Detection of Colorectal Neoplasms Using Linked Color Imaging: A Prospective, Randomized, Tandem Colonoscon Trial

    Hasegawa, I; Yamamura, T; Suzuki, H; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, E; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Kawashima, H; Nakamura, M; Fujishiro, M

    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY   19 巻 ( 8 ) 頁: 1708 - +   2021年8月

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  59. Difference of efficacy for small bowel lesion in Crohn

    Sawada T., Nakamura M., Yamamura T., Maeda K., Ishikawa E., Fujishiro M.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   36 巻   頁: 116 - 116   2021年8月

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  60. A forward-viewing radial-array echoendoscope is useful for diagnosing the depth of colorectal neoplasia invasion

    Kuno, T; Yamamura, T; Nakamura, M; Maeda, K; Sawada, T; Mizutani, Y; Esaki, M; Ishikawa, T; Furukawa, K; Ohno, E; Kawashima, H; Fujishiro, M

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   35 巻 ( 8 ) 頁: 4389 - 4398   2021年8月

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  61. Subjective Symptoms in Patients with Eosinophilic Esophagitis Are Related to Esophageal Wall Thickness and Esophageal Body Pressure

    Muroi, K; Kakushima, N; Furukawa, K; Ishikawa, E; Sawada, T; Ishikawa, T; Maeda, K; Yamamura, T; Ohno, E; Nakamura, M; Kawashima, H; Funasaka, K; Miyahara, R; Fujishiro, M

    DIGESTIVE DISEASES AND SCIENCES   66 巻 ( 7 ) 頁: 2291 - 2300   2021年7月

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  62. Lewis score on capsule endoscopy can predict the prognosis in patients with small bowel lesions of Crohn's disease

    Nishikawa, T; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, E; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Honda, T; Kawashima, H; Ishigami, M; Fujishiro, M

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   36 巻 ( 7 ) 頁: 1851 - 1858   2021年7月

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    記述言語:英語  

    DOI: 10.1111/jgh.15366

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  63. Long-Term Prognostic Predictors of Esophageal Squamous Cell Carcinoma Potentially Indicated for Endoscopic Submucosal Dissection

    Suzuki, T; Furukawa, K; Funasaka, K; Ishikawa, E; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Miyahara, R; Fujishiro, M

    DIGESTION   102 巻 ( 4 ) 頁: 563 - 571   2021年6月

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    記述言語:英語  

    DOI: 10.1159/000510091

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  64. Comparison of High-Resolution Manometry in Patients Complaining of Dysphagia among Patients with or without Diabetes Mellitus

    Muroi, K; Miyahara, R; Funasaka, K; Furukawa, K; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Onoue, T; Arima, H; Hirooka, Y; Fujishiro, M

    DIGESTION   102 巻 ( 4 ) 頁: 554 - 562   2021年6月

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    記述言語:英語  

    DOI: 10.1159/000510081

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  65. An evaluation of resectability among endoscopic treatment methods for rectal neuroendocrine tumors &lt;10 mm

    Toriyama, K; Yamamura, T; Nakamura, M; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, E; Furukawa, K; Ishikawa, T; Ohno, E; Kawashima, H; Fujishiro, M

    ARAB JOURNAL OF GASTROENTEROLOGY   22 巻 ( 2 ) 頁: 104 - 110   2021年6月

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  66. New modality for the quantitative evaluation of tissue elasticity using a forward-viewing radial-array echoendoscope for colorectal neoplasms

    Esaki, M; Yamamura, T; Nakamura, M; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, E; Furukawa, K; Kawashima, H; Hirooka, Y; Fujishiro, M

    INTERNATIONAL JOURNAL OF COLORECTAL DISEASE   36 巻 ( 5 ) 頁: 919 - 927   2021年5月

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  67. Diagnostic performance of endoscopic ultrasonography-guided elastography for solid pancreatic lesions: Shear-wave measurements versus strain elastography with histogram analysis

    Ohno, E; Kawashima, H; Ishikawa, T; Iida, T; Suzuki, H; Uetsuki, K; Yashika, J; Yamada, K; Yoshikawa, M; Gibo, N; Aoki, T; Kataoka, K; Mori, H; Yamamura, T; Furukawa, K; Nakamura, M; Hirooka, Y; Fujishiro, M

    DIGESTIVE ENDOSCOPY   33 巻 ( 4 ) 頁: 629 - 638   2021年5月

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    記述言語:英語  

    DOI: 10.1111/den.13791

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  68. Clinical Features of Ischemic Enteritis Diagnosed by Double-Balloon Endoscopy

    Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, E; Kakushima, N; Furukawa, K; Ishikawa, T; Ohno, E; Honda, T; Kawashima, H; Ishigami, M; Fujishiro, M

    CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   2021 巻   頁: 8875564   2021年4月

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  69. Filtrated Adipose Tissue-Derived Mesenchymal Stem Cell Lysate Ameliorates Experimental Acute Colitis in Mice

    Nishikawa, T; Maeda, K; Nakamura, M; Yamamura, T; Sawada, T; Mizutani, Y; Ito, T; Ishikawa, T; Furukawa, K; Ohno, E; Miyahara, R; Kawashima, H; Honda, T; Ishigami, M; Yamamoto, T; Matsumoto, S; Hotta, Y; Fujishiro, M

    DIGESTIVE DISEASES AND SCIENCES   66 巻 ( 4 ) 頁: 1034 - 1044   2021年4月

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  70. Diagnostic yield of colon capsule endoscopy for Crohn's disease lesions in the whole gastrointestinal tract

    Yamada, K; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, E; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Kawashima, H; Honda, T; Ishigami, M; Fujishiro, M

    BMC GASTROENTEROLOGY   21 巻 ( 1 ) 頁: 75   2021年2月

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  71. Ustekinumab is effective against small bowel lesions in Crohn's disease: two case reports

    Murate, K; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, E; Kakushima, N; Furukawa, K; Ohno, E; Honda, T; Kawashima, H; Ishigami, M; Fujishiro, M

    CLINICAL JOURNAL OF GASTROENTEROLOGY   14 巻 ( 1 ) 頁: 129 - 135   2021年2月

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  72. Clinical characteristics and long-term prognosis of autoimmune pancreatitis with renal lesions

    Ishikawa, T; Kawashima, H; Ohno, E; Iida, T; Suzuki, H; Uetsuki, K; Yashika, J; Yamada, K; Yoshikawa, M; Gibo, N; Aoki, T; Kataoka, K; Mori, H; Yamamura, T; Furukawa, K; Nakamura, M; Hirooka, Y; Fujishiro, M

    SCIENTIFIC REPORTS   11 巻 ( 1 ) 頁: 406   2021年1月

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  73. Neurokinin 3 receptor-selective agonist, senktide, decreases core temperature in Japanese Black cattle

    Nakamura S., Miwa M., Morita Y., Ohkura S., Yamamura T., Wakabayashi Y., Matsuyama S.

    DOMESTIC ANIMAL ENDOCRINOLOGY   74 巻   2021年1月

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    記述言語:日本語  

    DOI: 10.1016/j.domaniend.2020.106522

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  74. Systematic review and meta-analysis of the diagnostic and therapeutic yield of small bowel endoscopy in patients with overt small bowel bleeding

    Uchida, G; Nakamura, M; Yamamura, T; Furukawa, K; Kawashima, H; Honda, T; Ishigami, M; Fujishiro, M

    DIGESTIVE ENDOSCOPY   33 巻 ( 1 ) 頁: 66 - 82   2021年1月

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    記述言語:英語  

    DOI: 10.1111/den.13669

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  75. Gastrointestinal tract metastasis of lung cancer: The PD-L1 expression and correlated clinicopathological variables

    Ishikawa, E; Nakaguro, M; Nakamura, M; Yamamura, T; Sawada, T; Mizutani, Y; Maeda, K; Furukawa, K; Shimoyama, Y; Kawashima, H; Fujishiro, M

    PATHOLOGY INTERNATIONAL   71 巻 ( 1 ) 頁: 33 - 41   2021年1月

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    記述言語:英語  

    DOI: 10.1111/pin.13048

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  76. A novel Lugol's iodine staining technique to visualize the upper margin of the surgical anal canal intraoperatively for Hirschsprung disease: a case series

    Yokota, K; Amano, H; Kudo, T; Yamamura, T; Tanaka, Y; Tainaka, T; Shirota, C; Sumida, W; Makita, S; Takimoto, A; Nakamura, M; Fujishiro, M; Hinoki, A; Uchida, H

    BMC SURGERY   20 巻 ( 1 ) 頁: 317   2020年12月

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  77. The microbiome can predict mucosal healing in small intestine in patients with Crohn's disease

    Hattori, S; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Yamamoto, K; Ishikawa, T; Furukawa, K; Ohno, E; Honda, T; Kawashima, H; Ishigami, M; Hirooka, Y; Fujishiro, M

    JOURNAL OF GASTROENTEROLOGY   55 巻 ( 12 ) 頁: 1138 - 1149   2020年12月

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  78. Accuracy of carbon dioxide insufflation for endoscopic retrograde cholangiopancreatography using double-balloon endoscopy

    Niwa, Y; Nakamura, M; Kawashima, H; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, E; Ishikawa, T; Kakushima, N; Furukawa, K; Ohno, E; Honda, T; Ishigami, M; Fujishiro, M

    WORLD JOURNAL OF GASTROENTEROLOGY   26 巻 ( 42 ) 頁: 6669 - 6678   2020年11月

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  79. Mutation analysis of gastrointestinal stromal tumors using RNA obtained via endoscopic ultrasound-guided fine-needle aspiration

    Funasaka, K; Miyahara, R; Furukawa, K; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Hirooka, Y; Ohmiya, N; Fujishiro, M

    TRANSLATIONAL ONCOLOGY   13 巻 ( 11 ) 頁: 100848   2020年11月

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  80. Endoscopic Activity and Serum TNF-α Level at Baseline Are Associated With Clinical Response to Ustekinumab in Crohn's Disease Patients

    Murate, K; Maeda, K; Nakamura, M; Sugiyama, D; Wada, H; Yamamura, T; Sawada, T; Mizutani, Y; Ishikawa, T; Furukawa, K; Ohno, E; Honda, T; Kawashima, H; Miyahara, R; Ishigami, M; Nishikawa, H; Fujishiro, M

    INFLAMMATORY BOWEL DISEASES   26 巻 ( 11 ) 頁: 1669 - 1681   2020年11月

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    記述言語:英語  

    DOI: 10.1093/ibd/izaa086

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  81. Computer-aided diagnosis for characterization of colorectal lesions: comprehensive software that includes differentiation of serrated lesions

    Pu, LZCT; Maicas, G; Tian, Y; Yamamura, T; Nakamura, M; Suzuki, H; Singh, G; Rana, K; Hirooka, Y; Burt, AD; Fujishiro, M; Carneiro, G; Singh, R

    GASTROINTESTINAL ENDOSCOPY   92 巻 ( 4 ) 頁: 891 - 899   2020年10月

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  82. Comparison of different virtual chromoendoscopy classification systems for the characterization of colorectal lesions

    Pu, LZCT; Yamamura, T; Nakamura, M; Koay, DSC; Ovenden, A; Edwards, S; Burt, AD; Hirooka, Y; Fujishiro, M; Singh, R

    JGH OPEN   4 巻 ( 5 ) 頁: 818 - 826   2020年10月

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    記述言語:英語  

    DOI: 10.1002/jgh3.12382

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  83. Low ETV1 mRNA expression is associated with recurrence in gastrointestinal stromal tumors

    Sakamaki, K; Funasaka, K; Miyahara, R; Furukawa, K; Yamamura, T; Ohno, E; Nakamura, M; Kawashima, H; Hirooka, Y; Fujishiro, M; Goto, H

    SCIENTIFIC REPORTS   10 巻 ( 1 ) 頁: 14767   2020年9月

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  84. Reappraisal of Primary Epstein-Barr Virus (EBV)-positive Diffuse Large B-Cell Lymphoma of the Gastrointestinal Tract Comparative Analysis Among Immunosuppressed and Nonimmunosuppressed Stage I and II-IV Patients

    Miyagi, S; Ishikawa, E; Nakamura, M; Shimada, K; Yamamura, T; Furukawa, K; Tanaka, T; Mabuchi, S; Tsuyuki, Y; Kohno, K; Sakakibara, A; Satou, A; Kato, S; Fujishiro, M; Nakamura, S

    AMERICAN JOURNAL OF SURGICAL PATHOLOGY   44 巻 ( 9 ) 頁: 1173 - 1183   2020年9月

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  85. Learning curve for mastery of colorectal endoscopic submucosal dissection: Perspectives from a large Japanese cohort

    Pu, LZCT; Yamamura, T; Nakamura, M; Esaki, M; Kaosombatwattana, U; Rodriguez, MR; Edwards, S; Burt, AD; Singh, R; Hirooka, Y; Fujishiro, M

    JGH OPEN   4 巻 ( 4 ) 頁: 611 - 616   2020年8月

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    記述言語:英語  

    DOI: 10.1002/jgh3.12298

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  86. Polyp Detection Rate as a Surrogate for Adenoma and Sessile Serrated Adenoma/Polyp Detection Rates

    Pu, LZCT; Singh, G; Rana, K; Nakamura, M; Yamamura, T; Krishnamurthi, S; Ovenden, A; Edwards, S; Ruszkiewicz, A; Hirooka, Y; Fujishiro, M; Burt, AD; Singh, R

    GASTROINTESTINAL TUMORS   7 巻 ( 3 ) 頁: 74 - 82   2020年7月

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    記述言語:英語  

    DOI: 10.1159/000505622

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  87. Use of Immunostaining for the diagnosis of Lymphovascular invasion in superficial Barrett's esophageal adenocarcinoma

    Hosono, I; Miyahara, R; Furukawa, K; Funasaka, K; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Yokoi, T; Hirooka, Y; Fujishiro, M; Tsukamoto, T

    BMC GASTROENTEROLOGY   20 巻 ( 1 ) 頁: 175   2020年6月

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  88. PROSPECTIVE MULTICENTER STUDY ON THE USEFULNESS OF EUS-GUIDED FINE NEEDLE BIOPSY FOR THE DIAGNOSIS OF AUTOIMMUNE PANCREATITIS USING A 22-GAUGE FRANSEEN NEEDLE

    Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Nishio Ryo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Yamada Kenta, Yashika Jun, Yoshikawa Masakatsu, Gibo Noriaki, Aoki Toshinori, Kataoka Kunio, Mori Hiroshi, Keiko Maeda, Sawada Tsunaki, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Fujishiro Mitsuhiro

    GASTROINTESTINAL ENDOSCOPY   91 巻 ( 6 ) 頁: AB172 - AB172   2020年6月

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  89. NOVEL METHOD TO DETERMINE THE DEPTH OF INVASION IN COLORECTAL NEOPLASMS WITH ULTRASOUND ELASTOGRAPHY USING A FORWARD-VIEWING RADIAL-ARRAY ECHOENDOSCOPE

    Esaki, M; Yamamura, T; Nakamura, M; Keiko, M; Sawada, T; Mizutani, Y; Kuno, T; Yamada, K; Hasegawa, I; Ishikawa, T; Furukawa, K; Ohno, E; Kawashima, H; Fujishiro, M

    GASTROINTESTINAL ENDOSCOPY   91 巻 ( 6 ) 頁: AB430 - AB430   2020年6月

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  90. NOVEL METHOD TO DETERMINE THE DEPTH OF INVASION IN COLORECTAL NEOPLASMS WITH ULTRASOUND ELASTOGRAPHY USING A FORWARD-VIEWING RADIAL-ARRAY ECHOENDOSCOPE

    Esaki Masaya, Yamamura Takeshi, Nakamura Masanao, Keiko Maeda, Sawada Tsunaki, Mizutani Yasuyuki, Kuno Takeshi, Yamada Kentaro, Hasegawa Issei, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Fujishiro Mitsuhiro

    GASTROINTESTINAL ENDOSCOPY   91 巻 ( 6 ) 頁: AB430 - AB430   2020年6月

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  91. PROSPECTIVE MULTICENTER STUDY ON THE USEFULNESS OF EUS-GUIDED FINE NEEDLE BIOPSY FOR THE DIAGNOSIS OF AUTOIMMUNE PANCREATITIS USING A 22-GAUGE FRANSEEN NEEDLE

    Ishikawa, T; Kawashima, H; Ohno, E; Nishio, R; Iida, T; Suzuki, H; Uetsuki, K; Yamada, K; Yashika, J; Yoshikawa, M; Gibo, N; Aoki, T; Kataoka, K; Mori, H; Keiko, M; Sawada, T; Yamamura, T; Furukawa, K; Nakamura, M; Fujishiro, M

    GASTROINTESTINAL ENDOSCOPY   91 巻 ( 6 ) 頁: AB172 - AB172   2020年6月

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  92. EVALUATION OF RESECTABILITY BETWEEN ENDOSCOPIC TREATMENT METHODS FOR RECTAL NEUROENDOCRINE TUMOR

    Toriyama Kazuhiro, Yamamura Takeshi, Nakamura Masanao, Keiko Maeda, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Fujishiro Mitsuhiro

    GASTROINTESTINAL ENDOSCOPY   91 巻 ( 6 ) 頁: AB101 - AB101   2020年6月

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  93. EVALUATION OF RESECTABILITY BETWEEN ENDOSCOPIC TREATMENT METHODS FOR RECTAL NEUROENDOCRINE TUMOR

    Toriyama, K; Yamamura, T; Nakamura, M; Keiko, M; Sawada, T; Mizutani, Y; Ishikawa, T; Furukawa, K; Ohno, E; Kawashima, H; Fujishiro, M

    GASTROINTESTINAL ENDOSCOPY   91 巻 ( 6 ) 頁: AB101 - AB101   2020年6月

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  94. ENDOSCOPIC DIAGNOSIS USING MAGNIFYING IMAGE-ENHANCED ENDOSCOPY FOR SUPERFICIAL NON-AMPULLARY DUODENAL EPITHELIAL TUMORS

    Furukawa Kazuhiro, Miyahara Ryoji, Funasaka Kohei, Sawada Tsunaki, Keiko Maeda, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Fujishiro Mitsuhiro

    GASTROINTESTINAL ENDOSCOPY   91 巻 ( 6 ) 頁: AB618 - AB618   2020年6月

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  95. ENDOSCOPIC DIAGNOSIS USING MAGNIFYING IMAGE-ENHANCED ENDOSCOPY FOR SUPERFICIAL NON-AMPULLARY DUODENAL EPITHELIAL TUMORS

    Furukawa Kazuhiro, Miyahara Ryoji, Funasaka Kohei, Sawada Tsunaki, Keiko Maeda, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Fujishiro Mitsuhiro

    GASTROINTESTINAL ENDOSCOPY   91 巻 ( 6 ) 頁: AB618 - AB618   2020年6月

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  96. ENDOSCOPIC DIAGNOSIS USING MAGNIFYING IMAGE-ENHANCED ENDOSCOPY FOR SUPERFICIAL NON-AMPULLARY DUODENAL EPITHELIAL TUMORS

    Furukawa, K; Miyahara, R; Funasaka, K; Sawada, T; Keiko, M; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Fujishiro, M

    GASTROINTESTINAL ENDOSCOPY   91 巻 ( 6 ) 頁: AB618 - AB618   2020年6月

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  97. Nonexposed wall-inversion surgery as a novel local resection method for neoplasms in the gastrointestinal tract

    Fujishiro, M; Furukawa, K; Yamamura, T; Nakamura, M; Honda, T; Maeda, O; Ishigami, M; Kawashima, H

    NAGOYA JOURNAL OF MEDICAL SCIENCE   82 巻 ( 2 ) 頁: 175 - 182   2020年5月

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  98. Narrow-band imaging for scar (NBI-SCAR) classification: from conception to multicenter validation

    Pu, LZCT; Chiam, KH; Yamamura, T; Nakamura, M; Berzin, TM; Mir, FF; de Moura, EGH; Neto, ACM; Koay, DSC; Loong, CK; Ovenden, A; Edwards, S; Burt, AD; Hirooka, Y; Fujishiro, M; Singh, R

    GASTROINTESTINAL ENDOSCOPY   91 巻 ( 5 ) 頁: 1146 - +   2020年5月

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  99. Different factors are associated with conventional adenoma and serrated colorectal neoplasia

    Pu, LZCT; Rana, K; Singh, G; Nakamura, M; Yamamura, T; Koay, DSC; Ovenden, A; Edwards, S; Ruszkiewicz, A; Hirooka, Y; Fujishiro, M; Burt, AD; Singh, R

    NAGOYA JOURNAL OF MEDICAL SCIENCE   82 巻 ( 2 ) 頁: 335 - 343   2020年5月

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  100. Clinical Factors Associated with Missing Colorectal Polyp on Colon Capsule Endoscopy

    Yamada, K; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, T; Furukawa, K; Ohno, E; Miyahara, R; Kawashima, H; Hotta, N; Hirooka, Y

    DIGESTION   101 巻 ( 3 ) 頁: 316 - 322   2020年5月

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    記述言語:英語  

    DOI: 10.1159/000498942

    Web of Science

    PubMed

  101. An International Study on the Diagnostic Accuracy of the Japan Narrow-Band Imaging Expert Team Classification for Colorectal Polyps Observed with Blue Laser Imaging

    Suzuki, H; Yamamura, T; Nakamura, M; Hsu, CM; Su, MY; Chen, TH; Chiu, CT; Hirooka, Y; Goto, H

    DIGESTION   101 巻 ( 3 ) 頁: 339 - 346   2020年5月

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    記述言語:英語  

    DOI: 10.1159/000499856

    Web of Science

    PubMed

  102. Double-balloon endoscopic retrograde cholangiopancreatography for patients who underwent liver operation: A retrospective study

    Nishio, R; Kawashima, H; Nakamura, M; Ohno, E; Ishikawa, T; Yamamura, T; Maeda, K; Sawada, T; Tanaka, H; Sakai, D; Miyahara, R; Ishigami, M; Hirooka, Y; Fujishiro, M

    WORLD JOURNAL OF GASTROENTEROLOGY   26 巻 ( 10 ) 頁: 1056 - 1066   2020年3月

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  103. Microbiota profile is different for early and invasive colorectal cancer and is consistent throughout the colon

    Pu, LZCT; Yamamoto, K; Honda, T; Nakamura, M; Yamamura, T; Hattori, S; Burt, AD; Singh, R; Hirooka, Y; Fujishiro, M

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   35 巻 ( 3 ) 頁: 433 - 437   2020年3月

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    記述言語:英語  

    DOI: 10.1111/jgh.14868

    Web of Science

    PubMed

  104. Usefulness of Endoscopic Ultrasound Elastography Combined With the Strain Ratio in the Estimation of Treatment Effect in Autoimmune Pancreatitis

    Ishikawa, T; Kawashima, H; Ohno, E; Tanaka, H; Maeda, K; Sawada, T; Yamamura, T; Furukawa, K; Nakamura, M; Miyahara, R; Ishigami, M; Fujishiro, M

    PANCREAS   49 巻 ( 2 ) 頁: E21 - E22   2020年2月

  105. Magnetic anchor-guided endoscopic submucosal dissection for colorectal tumors (with video)

    Matsuzaki, I; Hattori, M; Yamauchi, H; Goto, N; Iwata, Y; Yokoi, T; Tsunemi, M; Kobayashi, M; Yamamura, T; Miyahara, R

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   34 巻 ( 2 ) 頁: 1012 - 1018   2020年2月

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  106. Prognostic impact of PD-L1 expression in primary gastric and intestinal diffuse large B-cell lymphoma

    Ishikawa, E; Nakamura, M; Shimada, K; Tanaka, T; Satou, A; Kohno, K; Sakakibara, A; Furukawa, K; Yamamura, T; Miyahara, R; Nakamura, S; Kato, S; Fujishiro, M

    JOURNAL OF GASTROENTEROLOGY   55 巻 ( 1 ) 頁: 39 - 50   2020年1月

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  107. Generation of magnifying endoscopic images of gastric neoplasms based on an all-in-focus algorithm

    Matsui, K; Funasaka, K; Miyahara, R; Furukawa, K; Matsushita, M; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Watanabe, O; Ohara, K; Hirooka, Y; Goto, H

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   35 巻 ( 1 ) 頁: 65 - 70   2020年1月

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    記述言語:英語  

    DOI: 10.1111/jgh.14792

    Web of Science

    PubMed

  108. Endoscopic detorsion using single-balloon endoscopy for cecal volvulus

    Suzuki, H; Yamamura, T; Fujishiro, M

    DIGESTIVE ENDOSCOPY   32 巻 ( 1 ) 頁: 149 - 149   2020年1月

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    記述言語:英語  

    DOI: 10.1111/den.13558

    Web of Science

    PubMed

  109. Color information from linked color imaging is associated with invasion depth and vascular diameter in superficial esophageal squamous cell carcinoma

    Kobayashi, K; Miyahara, R; Funasaka, K; Furukawa, K; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Nakaguro, M; Okumura, Y; Hirooka, Y; Fujishiro, M

    DIGESTIVE ENDOSCOPY   32 巻 ( 1 ) 頁: 65 - 73   2020年1月

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    記述言語:英語  

    DOI: 10.1111/den.13469

    Web of Science

    PubMed

  110. Refractory Ulcerative Colitis Improved by Scheduled Combination Therapy of Vedolizumab and Granulocyte and Monocyte Adsorptive Apheresis

    Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, E; Ohashi, A; Kajikawa, G; Furukawa, K; Ohno, E; Honda, T; Kawashima, H; Ishigami, M; Fujishiro, M

    INTERNAL MEDICINE   59 巻 ( 23 ) 頁: 3009 - 3014   2020年

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  111. A Prospective Study of Factors Associated with Abdominal Pain in Patients during Unsedated Colonoscopy Using a Magnifying Endoscope

    Suzuki, H; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, T; Furukawa, K; Ohno, E; Honda, T; Kawashima, H; Ishigami, M; Fujishiro, M

    INTERNAL MEDICINE   59 巻 ( 15 ) 頁: 1795 - 1801   2020年

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  112. Nasal patency as a factor for successful transnasal endoscopy

    Nagaya, T; Miyahara, R; Funasaka, K; Furukawa, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Nakashima, T; Nakata, S; Hirooka, Y

    NAGOYA JOURNAL OF MEDICAL SCIENCE   81 巻 ( 4 ) 頁: 587 - 595   2019年11月

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  113. The relationship between portal hypertension and the microbiome

    Yamamoto, K; Honda, T; Hattori, S; Pu, LZCT; Ito, T; Yamamura, T; Ishizu, Y; Kuzuya, T; Ishigami, M; Fujishiro, M

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   34 巻   頁: 106 - 107   2019年9月

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  114. Specific members of gut microbiota predict mucosal healing in Crohn's disease

    Hattori S., Nakamura M., Yamamura T., Maeda K., Sawada T., Mizutani Y., Yamamoto K., Pu L. Zorron Cheng Tao, Honda T., Ishikawa T., Furukawa K., Ohno E., Miyahara R., Kawashima H., Fujishiro M.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   34 巻   頁: 152 - 152   2019年9月

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  115. Microbiota profile is markedly different for early and invasive colorectal cancer and is consistent throughout the colon

    Pu L. Zorron Cheng Tao, Yamamoto K., Honda T., Hattori S., Nakamura M., Yamamura T., Burt A., Hirooka Y., Singh R., Fujishiro M.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   34 巻   頁: 40 - 41   2019年9月

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  116. Microbiota profile is markedly different for early and invasive colorectal cancer and is consistent throughout the colon

    Pu, LZCT; Yamamoto, K; Honda, T; Hattori, S; Nakamura, M; Yamamura, T; Burt, A; Hirooka, Y; Singh, R; Fujishiro, M

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   34 巻   頁: 40 - 41   2019年9月

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  117. Modified Sano's classification is the most accurate for characterizing serrated polyps and adenomas with different virtual chromoendoscopy methods: Results of a prospective observational study

    Pu L. Zorron Cheng Tao, Yamamura T., Nakamura M., Koay D., Ovenden A., Edwards S., Hirooka Y., Burt A., Fujishiro M., Singh R.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   34 巻   頁: 226 - 227   2019年9月

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  118. Modified Sano's classification is the most accurate for characterizing serrated polyps and adenomas with different virtual chromoendoscopy methods: Results of a prospective observational study

    Pu, LZCT; Yamamura, T; Nakamura, M; Koay, D; Ovenden, A; Edwards, S; Hirooka, Y; Burt, A; Fujishiro, M; Singh, R

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   34 巻   頁: 226 - 227   2019年9月

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  119. Narrow-band imaging for scar (NBI-SCAR) classification: From conception to multicenter validation

    Pu, LZCT; Chiam, K; Yamamura, T; Nakamura, M; Berzin, T; Mir, F; De Moura, E; Neto, AM; Koay, D; Loong, C; Ovenden, A; Edwards, S; Hirooka, Y; Fujishiro, M; Burt, A; Singh, R

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   34 巻   頁: 227 - 228   2019年9月

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  120. Objective evaluation of the therapeutic effect of ustekinumab on Crohn's disease

    Yamamura, T; Nakamura, M; Murate, K; Maeda, K; Sawada, T; Mizutani, Y; Nishikawa, T; Hattori, S; Yamamoto, K; Pu, LZCT; Ishikawa, T; Furukawa, K; Ohno, E; Miyahara, R; Kawashima, H; Fujishiro, M

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   34 巻   頁: 145 - 145   2019年9月

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  121. Objective evaluation of the therapeutic effect of ustekinumab on Crohn's disease

    Yamamura T., Nakamura M., Murate K., Maeda K., Sawada T., Mizutani Y., Nishikawa T., Hattori S., Yamamoto K., Pu L. Zorron Cheng Tao, Ishikawa T., Furukawa K., Ohno E., Miyahara R., Kawashima H., Fujishiro M.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   34 巻   頁: 145 - 145   2019年9月

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  122. Prospective study assessing a comprehensive computer-aided diagnosis for characterization of colorectal lesions: Results from different centers and imaging technologies

    Pu L. Zorron Cheng Tao, Maicas G., Tian Y., Yamamura T., Singh G., Rana K., Suzuki H., Nakamura M., Hirooka Y., Burt A., Fujishiro M., Carneiro G., Singh R.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   34 巻   頁: 25 - 26   2019年9月

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  123. Prospective study assessing a comprehensive computer-aided diagnosis for characterization of colorectal lesions: Results from different centers and imaging technologies

    Pu, LZCT; Maicas, G; Tian, Y; Yamamura, T; Singh, G; Rana, K; Suzuki, H; Nakamura, M; Hirooka, Y; Burt, A; Fujishiro, M; Carneiro, G; Singh, R

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   34 巻   頁: 25 - 26   2019年9月

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  124. Specific members of gut microbiota predict mucosal healing in Crohn's disease

    Hattori, S; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Yamamoto, K; Pu, LZCT; Honda, T; Ishikawa, T; Furukawa, K; Ohno, E; Miyahara, R; Kawashima, H; Fujishiro, M

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   34 巻   頁: 152 - 152   2019年9月

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  125. Specific members of gut microbiota predict mucosal healing in Crohn's disease

    Hattori, S; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Yamamoto, K; Pu, LZCT; Honda, T; Ishikawa, T; Furukawa, K; Ohno, E; Miyahara, R; Kawashima, H; Fujishiro, M

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   34 巻   頁: 152 - 152   2019年9月

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  126. Learning curve for mastery of colorectal endoscopic submucosal dissection: Perspectives from a Japanese cohort of more than 500 procedures

    Pu, LZCT; Yamamura, T; Kaosombatwattana, U; Esaki, M; Edwards, MNS; Edwards, S; Burt, A; Hirooka, Y; Singh, R; Fujishiro, M

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   34 巻   頁: 20 - 21   2019年9月

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  127. THE PROPAGATION DISPLAY METHOD IMPROVES THE REPRODUCIBILITY OF PANCREATIC SHEAR WAVE ELASTOGRAPHY

    Hashizume, K; Hirooka, Y; Kawashima, H; Ohno, E; Ishikawa, T; Kawai, M; Suhara, H; Takeyama, T; Koya, T; Tanaka, H; Sakai, D; Yamamura, T; Furukawa, K; Funasaka, K; Nakamura, M; Miyahara, R; Watanabe, O; Ishigami, M; Kuwahara, T; Hashimoto, S; Goto, H

    ULTRASOUND IN MEDICINE AND BIOLOGY   45 巻 ( 8 ) 頁: 2242 - 2247   2019年8月

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  128. USEFULLNESS OF EUS-GUIDED SHEAR-WAVE MEASUREMENT (EUS-SWM) FOR THE ASSESSMENT OF ACTIVITIES OF AUTOIMMUNE PANCREATITIS; A PROSPECTIVE EXPLORATORY STUDY

    Ohno Eizaburo, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya, Tanaka Hiroyuki, Sakai Daisuke, Iida Tadashi, Nishio Ryo, Suzuki Hirotaka, Uetsuki Kota, Yashika Jun, Yamada Kenta, Yoshikawa Masakatsu, Gibo Noriaki, Aoki Toshinori, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Miyahara Ryoji

    GASTROINTESTINAL ENDOSCOPY   89 巻 ( 6 ) 頁: AB608 - AB608   2019年6月

  129. USEFULLNESS OF EUS-GUIDED SHEAR-WAVE MEASUREMENT (EUS-SWM) FOR THE ASSESSMENT OF ACTIVITIES OF AUTOIMMUNE PANCREATITIS; A PROSPECTIVE EXPLORATORY STUDY

    Ohno, E; Hirooka, Y; Kawashima, H; Ishikawa, T; Tanaka, H; Sakai, D; Iida, T; Nishio, R; Suzuki, H; Uetsuki, K; Yashika, J; Yamada, K; Yoshikawa, M; Gibo, N; Aoki, T; Yamamura, T; Furukawa, K; Nakamura, M; Miyahara, R

    GASTROINTESTINAL ENDOSCOPY   89 巻 ( 6 ) 頁: AB608 - AB608   2019年6月

  130. USEFULLNESS OF EUS-GUIDED SHEAR-WAVE MEASUREMENT (EUS-SWM) FOR THE ASSESSMENT OF ACTIVITIES OF AUTOIMMUNE PANCREATITIS; A PROSPECTIVE EXPLORATORY STUDY

    Ohno Eizaburo, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya, Tanaka Hiroyuki, Sakai Daisuke, Iida Tadashi, Nishio Ryo, Suzuki Hirotaka, Uetsuki Kota, Yashika Jun, Yamada Kenta, Yoshikawa Masakatsu, Gibo Noriaki, Aoki Toshinori, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Miyahara Ryoji

    GASTROINTESTINAL ENDOSCOPY   89 巻 ( 6 ) 頁: AB608 - AB608   2019年6月

  131. USEFULNESS OF THE FORWARD-VIEWING RADIAL-ARRAY ECHOENDOSCOPE IN THE DIAGNOSIS OF INVASION DEPTH OF COLORECTAL NEOPLASIA

    Kuno Takeshi, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Suzuki Hiroto, Esaki Masaya, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   89 巻 ( 6 ) 頁: AB324 - AB324   2019年6月

  132. USEFULNESS OF THE FORWARD-VIEWING RADIAL-ARRAY ECHOENDOSCOPE IN THE DIAGNOSIS OF INVASION DEPTH OF COLORECTAL NEOPLASIA

    Kuno, T; Yamamura, T; Nakamura, M; Maeda, K; Sawada, T; Mizutani, Y; Suzuki, H; Esaki, M; Ishikawa, T; Furukawa, K; Ohno, E; Kawashima, H; Miyahara, R; Hirooka, Y

    GASTROINTESTINAL ENDOSCOPY   89 巻 ( 6 ) 頁: AB324 - AB324   2019年6月

  133. FACTORS RELATED TO MISSED COLORECTAL POLYPS ON COLON CAPSULE ENDOSCOPY IN CLINICAL PRACTICE

    Yamada, K; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Niwa, Y; Ishikawa, E; Otsuka, H; Suzuki, H; Ishikawa, T; Furukawa, K; Ohno, E; Miyahara, R; Kawashima, H; Hotta, N; Pu, LZCT; Hirooka, Y

    GASTROINTESTINAL ENDOSCOPY   89 巻 ( 6 ) 頁: AB155 - AB155   2019年6月

  134. FACTORS RELATED TO MISSED COLORECTAL POLYPS ON COLON CAPSULE ENDOSCOPY IN CLINICAL PRACTICE

    Yamada Keisaku, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Otsuka Hiroyuki, Suzuki Hiroto, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hotta Naoki, Pu Leonardo Zorron Cheng Tao, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   89 巻 ( 6 ) 頁: AB155 - AB155   2019年6月

  135. FACTORS RELATED TO MISSED COLORECTAL POLYPS ON COLON CAPSULE ENDOSCOPY IN CLINICAL PRACTICE

    Yamada Keisaku, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Otsuka Hiroyuki, Suzuki Hiroto, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hotta Naoki, Pu Leonardo Zorron Cheng Tao, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   89 巻 ( 6 ) 頁: AB155 - AB155   2019年6月

  136. CLINICAL SIGNIFICANCE OF THE PATENCY OF GASTROINTESTINAL TRACT IN CROHN'S DISEASE EVALUATED BY PATENCY CAPSULE

    Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Kuno, T; Yamada, K; Ishikawa, T; Furukawa, K; Ohno, E; Miyahara, R; Kawashima, H; Hirooka, Y

    GASTROINTESTINAL ENDOSCOPY   89 巻 ( 6 ) 頁: AB333 - AB333   2019年6月

  137. CLINICAL SIGNIFICANCE OF THE PATENCY OF GASTROINTESTINAL TRACT IN CROHN'S DISEASE EVALUATED BY PATENCY CAPSULE

    Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Kuno Takeshi, Yamada Keisaku, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY   89 巻 ( 6 ) 頁: AB333 - AB333   2019年6月

  138. The utility of ultrathin endoscopy with flexible spectral imaging color enhancement for early gastric cancer

    Yokoyama, T; Miyahara, R; Funasaka, K; Furukawa, K; Yamamura, T; Ohno, E; Nakamura, M; Kawashima, H; Watanabe, O; Hirooka, Y; Hirakawa, A; Goto, H

    NAGOYA JOURNAL OF MEDICAL SCIENCE   81 巻 ( 2 ) 頁: 241 - 248   2019年5月

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  139. Effect of time of day and specialty on polyp detection rates in Australia

    Pu, LZCT; Lu, K; Ovenden, A; Rana, K; Singh, G; Krishnamurthi, S; Edwards, S; Wilson, B; Nakamura, M; Yamamura, T; Ruszkiewicz, A; Hirooka, Y; Burt, AD; Singh, R

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   34 巻 ( 5 ) 頁: 899 - 906   2019年5月

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    記述言語:英語  

    DOI: 10.1111/jgh.14566

    Web of Science

    PubMed

  140. Colorectal endoscopic submucosal dissection in special locations

    Kaosombatwattana, U; Yamamura, T; Nakamura, M; Hirooka, Y; Goto, H

    WORLD JOURNAL OF GASTROINTESTINAL ENDOSCOPY   11 巻 ( 4 ) 頁: 262 - 270   2019年4月

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  141. Preoperative endoscopic predictors of severe submucosal fibrosis in colorectal tumors undergoing endoscopic submucosal dissection

    Kaosombatwattana, U; Yamamura, T; Limsrivilai, J; Nakamura, M; Leelakusolvong, S; Hirooka, Y; Goto, H

    ENDOSCOPY INTERNATIONAL OPEN   7 巻 ( 4 ) 頁: E421 - E430   2019年4月

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    記述言語:英語  

    DOI: 10.1055/a-0848-8225

    Web of Science

    PubMed

  142. Utility of linked color imaging for endoscopic diagnosis of early gastric cancer

    Fujiyoshi, T; Miyahara, R; Funasaka, K; Furukawa, K; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Nakaguro, M; Nakatochi, M; Hirooka, Y

    WORLD JOURNAL OF GASTROENTEROLOGY   25 巻 ( 10 ) 頁: 1248 - 1258   2019年3月

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  143. Plummer-Vinson Syndrome with Esophageal Web Formation in which Detailed Endoscopic Images Were Obtained

    Hirose, T; Funasaka, K; Furukawa, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Miyahara, R; Hirooka, Y

    INTERNAL MEDICINE   58 巻 ( 6 ) 頁: 785 - 789   2019年

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  144. Lewis Score on Capsule Endoscopy as a Predictor of the Risk for Crohn's Disease-Related Emergency Hospitalization and Clinical Relapse in Patients with Small Bowel Crohn's Disease

    Nishikawa, T; Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, T; Furukawa, K; Ohno, E; Miyahara, R; Kawashima, H; Hirooka, Y

    GASTROENTEROLOGY RESEARCH AND PRACTICE   2019 巻   頁: 4274257   2019年

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  145. Clinical Impact of EUS-Guided Fine Needle Biopsy Using a Novel Franseen Needle for Histological Assessment of Pancreatic Diseases

    Ishikawa, T; Kawashima, H; Ohno, E; Tanaka, H; Sakai, D; Iida, T; Nishio, R; Yamamura, T; Furukawa, K; Nakamura, M; Miyahara, R; Hashimoto, S; Ishigami, M; Hirooka, Y

    CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   2019 巻   頁: 8581743   2019年

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  146. Clinicopathological analysis of primary intestinal diffuse large B-cell lymphoma: Prognostic evaluation of CD5, PD-L1, and Epstein-Barr virus on tumor cells

    Ishikawa, E; Kato, S; Shimada, K; Tanaka, T; Suzuki, Y; Satou, A; Kohno, K; Sakakibara, A; Yamamura, T; Nakamura, M; Miyahara, R; Goto, H; Nakamura, S; Hirooka, Y

    CANCER MEDICINE   7 巻 ( 12 ) 頁: 6051 - 6063   2018年12月

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    記述言語:英語  

    DOI: 10.1002/cam4.1875

    Web of Science

    PubMed

  147. Validity of Capsule Endoscopy in Monitoring Therapeutic Interventions in Patients with Crohn's Disease

    Nakamura, M; Yamamura, T; Maeda, K; Sawada, T; Mizutani, Y; Ishikawa, T; Furukawa, K; Ohno, E; Kawashima, H; Miyahara, R; Koulaouzidis, A; Hirooka, Y

    JOURNAL OF CLINICAL MEDICINE   7 巻 ( 10 )   2018年10月

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    記述言語:英語  

    DOI: 10.3390/jcm7100311

    Web of Science

    PubMed

  148. Prospective study predicting histology in colorectal lesions using wNICE, wJNET, and MS classifications

    Pu, LZCT; Yamamura, T; Nakamura, M; Koay, DSC; Ovenden, A; Edwards, S; Hoong, CK; Burt, AD; Hirooka, Y; Singh, R

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   33 巻   頁: 14 - 14   2018年9月

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  149. Prevalence and distribution of serrated polyps in the colon

    Pu, LZCT; Singh, G; Krishnamurthi, S; Ovenden, A; Nakamura, M; Yamamura, T; Rana, K; Lu, K; Edwards, S; Ruszkiewicz, A; Hoong, CK; Hirooka, Y; Burt, A; Singh, R

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   33 巻   頁: 185 - 186   2018年9月

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  150. Prospective study assessing associated factors in patients with colorectal lesions

    Pu, LZCT; Ovenden, A; Nakamura, M; Yamamura, T; Sawada, T; Koay, DSC; Edwards, S; Hoong, CK; Burt, AD; Hirooka, Y; Singh, R

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   33 巻   頁: 186 - 186   2018年9月

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  151. Effect of training and time of the day on polyp detection rates

    Pu, LZCT; Lu, K; Ovenden, A; Rana, K; Singh, G; Krishnamurthi, S; Edwards, S; Wilson, B; Nakamura, M; Yamamura, T; Ruszkiewicz, A; Hoong, CK; Hirooka, Y; Burt, AD; Singh, R

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   33 巻   頁: 184 - 185   2018年9月

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  152. Effect of training and time of the day on polyp detection rates

    Pu, LZCT; Lu, K; Ovenden, A; Rana, K; Singh, G; Krishnamurthi, S; Edwards, S; Wilson, B; Nakamura, M; Yamamura, T; Ruszkiewicz, A; Hoong, CK; Hirooka, Y; Burt, AD; Singh, R

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   33 巻   頁: 184 - 185   2018年9月

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  153. Objective evaluation of blood flow in the small-intestinal villous: quantification of findings from dynamic endoscopy with concomitant narrow-band imaging.

    Takeyama T, Hirooka Y, Kawashima H, Ohno E, Ishikawa T, Yamamura T, Furukawa K, Funasaka K, Nakamura M, Miyahara R, Ishigami M, Goto H

    Endoscopy international open   6 巻 ( 8 ) 頁: E941 - E949   2018年8月

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    記述言語:英語  

    DOI: 10.1055/a-0619-4965

    PubMed

  154. Increase in breath hydrogen concentration was correlated with the main pancreatic duct stenosis

    Sakai, D; Hirooka, Y; Kawashima, H; Ohno, E; Ishikawa, T; Suhara, H; Takeyama, T; Koya, T; Tanaka, H; Iida, T; Nishio, R; Suzuki, H; Uetsuki, K; Matsushita, M; Yamamura, T; Furukawa, K; Funasaka, K; Nakamura, M; Miyahara, R; Watanabe, O; Ishigami, M; Tsuruta, A; Shin, W; Goto, H

    JOURNAL OF BREATH RESEARCH   12 巻 ( 3 ) 頁: 036004   2018年7月

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  155. USEFULLNESS OF CONTRAST-ENHANCED HARMONIC EUS(CH-EUS) FOR THE PREOPERATIVE ASSESSMENT OF MPD INVOLVEMENT IN IPMN; A RETROSPECTIVE COMPARISON STUDY OF CH-EUS AND IDUS

    Ohno, E; Hirooka, Y; Kawashima, H; Ishikawa, T; Suhara, H; Takeyama, T; Koya, T; Tanaka, H; Sakai, D; Nishio, R; Iida, T; Suzuki, H; Uetsuki, K; Matsushita, M; Furukawa, K; Yamamura, T; Funasaka, K; Nakamura, M; Miyahara, R; Watanabe, O; Goto, H

    GASTROINTESTINAL ENDOSCOPY   87 巻 ( 6 ) 頁: AB426 - AB427   2018年6月

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  156. USEFULNESS OF HISTOLOGICAL ASSESSMENT WITH EUS-GUIDED FINE NEEDLE BIOPSY USING A NEW CORE NEEDLE IN PANCREATIC DISEASES

    Ishikawa, T; Hirooka, Y; Kawashima, H; Ohno, E; Suhara, H; Takeyama, T; Koya, T; Tanaka, H; Sakai, D; Nishio, R; Iida, T; Suzuki, H; Uetsuki, K; Matsushita, M; Yamamura, T; Furukawa, K; Funasaka, K; Nakamura, M; Miyahara, R; Watanabe, O; Goto, H

    GASTROINTESTINAL ENDOSCOPY   87 巻 ( 6 ) 頁: AB432 - AB433   2018年6月

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  157. THE DIAGNOSTIC ABILITY AND PITFALL OF JNET(JAPAN NBI EXPERT TEAM)CLASSIFICATION IN TRAINEES

    Suzuki, H; Yamamura, T; Watanabe, O; Nakamura, M; Matsushita, M; Sawada, T; Mizutani, Y; Ishikawa, E; Niwa, Y; Uchida, G; Otsuka, H; Nishikawa, T; Ishida, T; Yamada, K; Hattori, S; Kajikawa, G; Hashiguchi, H; Suhara, H; Ishikawa, T; Furukawa, K; Funasaka, K; Ohno, E; Kawashima, H; Miyahara, R; Hirooka, Y; Goto, H

    GASTROINTESTINAL ENDOSCOPY   87 巻 ( 6 ) 頁: AB489 - AB490   2018年6月

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  158. OUTCOMES AND PREDICTORS OF SEVERE SUBMUCOSAL FIBROSIS IN COLORECTAL ENDOSCOPIC SUBMUCOSAL DISSECTION

    Kaosombatwattana, U; Yamamura, T; Limsrivilai, J; Watanabe, O; Nakamura, M; Matsushita, M; Suhara, H; Ishikawa, T; Furukawa, K; Funasaka, K; Ohno, E; Miyahara, R; Kawashima, H; Leelakusolvong, S; Hirooka, Y; Goto, H

    GASTROINTESTINAL ENDOSCOPY   87 巻 ( 6 ) 頁: AB377 - AB377   2018年6月

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  159. PROSPECTIVE STUDY OF SMALL BOWEL CAPSULE ENDOSCOPY FOR EVALUATING THE THERAPEUTIC EFFECTS IN PATIENTS WITH CROHN'S DISEASE

    Nakamura, M; Hirooka, Y; Watanabe, O; Yamamura, T; Matsushita, M; Suhara, H; Ishikawa, T; Furukawa, K; Funasaka, K; Ohno, E; Kawashima, H; Miyahara, R; Koulaouzidis, A; Goto, H

    GASTROINTESTINAL ENDOSCOPY   87 巻 ( 6 ) 頁: AB393 - AB393   2018年6月

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  160. EVALUATION OF LOCAL RECURRENCE AFTER COLD POLYPECTOMY COMPARED WITH CONVENTIONAL HOT POLYPECTOMY IN A PROSPECTIVE RANDOMIZED CONTROLLED TRIAL

    Yamamura, T; Saito, M; Watanabe, O; Nakamura, M; Matsushita, M; Sawada, T; Mizutani, Y; Niwa, Y; Ishikawa, E; Suzuki, H; Otsuka, H; Uchida, G; Nishikawa, T; Ishida, T; Kuno, T; Yamada, K; Hattori, S; Hashiguchi, H; Suhara, H; Ishikawa, T; Furukawa, K; Funasaka, K; Ohno, E; Miyahara, R; Kawashima, H; Hirooka, Y; Goto, H

    GASTROINTESTINAL ENDOSCOPY   87 巻 ( 6 ) 頁: AB478 - AB478   2018年6月

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  161. DIAGNOSTIC IMAGING SYSTEM WITH VIRTUAL ENTEROSCOPY AND COMPUTER-AIDED DETECTION FOR EVALUATION OF SMALL BOWEL LESIONS OF CROHN'S DISEASE

    Furukawa, K; Miyahara, R; Funasaka, K; Suhara, H; Matsushita, M; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Watanabe, O; Oda, M; Mori, K; Hirooka, Y; Goto, H

    GASTROINTESTINAL ENDOSCOPY   87 巻 ( 6 ) 頁: AB304 - AB304   2018年6月

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  162. ENDOSCOPIC TREATMENT FOR SUPERFICIAL NON-AMPULLARY DUODENAL TUMORS

    Furukawa, K; Miyahara, R; Funasaka, K; Suhara, H; Matsushita, M; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Watanabe, O; Hirooka, Y; Goto, H

    GASTROINTESTINAL ENDOSCOPY   87 巻 ( 6 ) 頁: AB315 - AB316   2018年6月

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  163. Functional Correlation Between the Pancreas and the Small Intestine in Humans: The First Evaluation Using a Newly Developed Enteroscopy

    Hayashi, D; Hirooka, Y; Kawashima, H; Ohno, E; Ishikawa, T; Kuwahara, T; Kawai, M; Yamamura, T; Furukawa, K; Funasaka, K; Nakamura, M; Miyahara, R; Watanabe, O; Ishigami, M; Hashimoto, S; Goto, H

    PANCREAS   47 巻 ( 5 ) 頁: 601 - 608   2018年5月

  164. Fecal calprotectin reflects endoscopic activity in patients with small-bowel Crohn's disease according to double-balloon endoscopy findings

    Matsuura, R; Watanabe, O; Nakamura, M; Yamamura, T; Matsushita, M; Suhara, H; Furukawa, K; Ishikawa, T; Funasaka, K; Ohno, E; Kawashima, H; Miyahara, R; Hirooka, Y; Goto, H

    NAGOYA JOURNAL OF MEDICAL SCIENCE   80 巻 ( 2 ) 頁: 257 - 266   2018年5月

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  165. Nomogram-based prediction of rebleeding in small bowel bleeding patients: the 'PRSBB' score

    Uchida, G; Hirooka, Y; Nakamura, M; Watanabe, O; Yamamura, T; Matsushita, M; Suhara, H; Ishikawa, T; Furukawa, K; Funasaka, K; Ohno, E; Kawashima, H; Miyahara, R; Goto, H

    SCIENTIFIC REPORTS   8 巻 ( 1 ) 頁: 6378   2018年4月

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  166. Usefulness of shear wave elastography as a quantitative diagnosis of chronic pancreatitis

    Kuwahara, T; Hirooka, Y; Kawashima, H; Ohno, E; Ishikawa, T; Yamamura, T; Furukawa, K; Funasaka, K; Nakamura, M; Miyahara, R; Watanabe, O; Ishigami, M; Hashimoto, S; Goto, H

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   33 巻 ( 3 ) 頁: 756 - 761   2018年3月

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    記述言語:英語  

    DOI: 10.1111/jgh.13926

    Web of Science

    PubMed

  167. Clinical significance of gastrointestinal patency evaluation by using patency capsule in Crohn's disease

    Yoshimura, T; Hirooka, Y; Nakamura, M; Watanabe, O; Yamamura, T; Matsushita, M; Ishikawa, T; Furukawa, K; Funasaka, K; Ohno, E; Kawashima, H; Miyahara, R; Goto, H

    NAGOYA JOURNAL OF MEDICAL SCIENCE   80 巻 ( 1 ) 頁: 121 - 128   2018年2月

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  168. Endoscopic ultrasound in diagnosis of solid pancreatic lesions: Elastography or contrast-enhanced harmonic alone versus the combination.

    Chantarojanasiri T, Hirooka Y, Kawashima H, Ohno E, Kuwahara T, Yamamura T, Funasaka K, Nakamura M, Miyahara R, Ishigami M, Watanabe O, Hashimoto S, Hirakawa A, Ratanachu-Ek T, Goto H

    Endoscopy international open   5 巻 ( 11 ) 頁: E1136 - E1143   2017年11月

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    記述言語:英語  

    DOI: 10.1055/s-0043-118829

    PubMed

  169. Development and validation of a new scoring system to determine the necessity of small-bowel endoscopy in obscure gastrointestinal bleeding

    Uchida, G; Nakamura, M; Watanabe, O; Yamamura, T; Ishikawa, T; Furukawa, K; Funasaka, K; Ohno, E; Kawashima, H; Miyahara, R; Goto, H; Hirooka, Y

    DIGESTIVE AND LIVER DISEASE   49 巻 ( 11 ) 頁: 1218 - 1224   2017年11月

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  170. <i>In vivo</i> histological diagnosis for gastric cancer using endocytoscopy

    Tsurudome, I; Miyahara, R; Funasaka, K; Furukawa, K; Matsushita, M; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Watanabe, O; Nakaguro, M; Satou, A; Hirooka, Y; Goto, H

    WORLD JOURNAL OF GASTROENTEROLOGY   23 巻 ( 37 ) 頁: 6894 - 6901   2017年10月

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  171. Making decision to treat with infliximab by the result of periodic surveillance with double-balloon endoscopy after ilectomy can obtain mucosal healing and avoid re-operation on patients with Crohn's disease for a long-term follow-up study

    Watanabe, O; Nakamura, M; Yamamura, T; Matsushita, M; Saito, M; Matsuura, R; Sawada, T; Mizutani, Y; Niwa, Y; Ishikawa, E; Uchida, G; Otsuka, H; Suzuki, H; Nishikawa, T; Ishida, T; Yamada, K; Kuno, T; Hattori, S; Ishikawa, T; Furukawa, K; Funasaka, K; Ohno, E; Miyahara, R; Kawashima, H; Hirooka, Y; Goto, H

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   32 巻   頁: 287 - 287   2017年9月

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  172. ETV1 expression would be a predictive marker of malignancy in GIST

    Funasaka, K; Miyahara, R; Furukawa, K; Matsushita, M; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Watanabe, O; Hirooka, Y; Goto, H

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   32 巻   頁: 79 - 80   2017年9月

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  173. Clinical factors related to false-positive rates of patency capsule examination

    Sawada, T; Nakamura, M; Watanabe, O; Yamamura, T; Ishikawa, T; Furukawa, K; Funasaka, K; Ohno, E; Kawashima, H; Miyahara, R; Goto, H; Hirooka, Y

    THERAPEUTIC ADVANCES IN GASTROENTEROLOGY   10 巻 ( 8 ) 頁: 589 - 598   2017年8月

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  174. Quantitative diagnosis of chronic pancreatitis using EUS elastography

    Kuwahara, T; Hirooka, Y; Kawashima, H; Ohno, E; Ishikawa, T; Kawai, M; Suhara, H; Takeyama, T; Hashizume, K; Koya, T; Tanaka, H; Sakai, D; Yamamura, T; Furukawa, K; Funasaka, K; Nakamura, M; Miyahara, R; Watanabe, O; Ishigami, M; Hashimoto, S; Goto, H

    JOURNAL OF GASTROENTEROLOGY   52 巻 ( 7 ) 頁: 868 - 874   2017年7月

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  175. Inhibition of KDM4A activity as a strategy to suppress interleukin-6 production and attenuate colitis induction

    Ishiguro, K; Watanabe, O; Nakamura, M; Yamamura, T; Matsushita, M; Goto, H; Hirooka, Y

    CLINICAL IMMUNOLOGY   180 巻   頁: 120 - 127   2017年7月

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  176. Combinational use of lipid-based reagents for efficient transfection of primary fibroblasts and hepatoblasts

    Ishiguro, K; Watanabe, O; Nakamura, M; Yamamura, T; Matsushita, M; Goto, H; Hirooka, Y

    BIOTECHNIQUES   63 巻 ( 1 ) 頁: 37 - 39   2017年7月

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    記述言語:英語  

    DOI: 10.2144/000114569

    Web of Science

    PubMed

  177. The Study of Diagnostic Ability for the Colorectal Neoplasms by Imaged Enhanced Endoscopy Using by JNET (Japan NBI Expert Team) Classification

    Yamamura, T; Watanabe, O; Nakamura, M; Matsushita, M; Oshima, H; Sato, J; Matsuura, R; Saito, M; Mizutani, Y; Sawada, T; Niwa, Y; Ishikawa, E; Uchida, G; Otsuka, H; Suzuki, H; Nishikawa, T; Ishida, T; Ishikawa, T; Furukawa, K; Funasaka, K; Ohno, E; Kawashima, H; Miyahara, R; Hirooka, Y; Goto, H

    GASTROINTESTINAL ENDOSCOPY   85 巻 ( 5 ) 頁: AB402 - AB402   2017年5月

  178. The Outcome of Treatment in Hypopharyngeal and Cervical Esophageal Carcinoma

    Fujiyoshi, T; Miyahara, R; Funasaka, K; Furukawa, K; Matsushita, M; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Watanabe, O; Hirooka, Y; Goto, H

    GASTROINTESTINAL ENDOSCOPY   85 巻 ( 5 ) 頁: AB597 - AB598   2017年5月

  179. Predicting the Depth of Invasion of Esophageal Squamous Cell Carcinoma: Under Experience of Linked Colored Imaging With LED Light Source

    Kobayashi, K; Miyahara, R; Funasaka, K; Furukawa, K; Matsushita, M; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Watanabe, O; Hirooka, Y; Goto, H

    GASTROINTESTINAL ENDOSCOPY   85 巻 ( 5 ) 頁: AB527 - AB527   2017年5月

  180. Novel EMR Technique for Preoperative Diagnosis and Treatment of Submucosal Tumor in the Small Bowel at Double-Balloon Endoscopy

    Nakamura, M; Watanabe, O; Yamamura, T; Matsushita, M; Oshima, H; Sato, J; Saito, M; Matsuura, R; Mizutani, Y; Sawada, T; Niwa, Y; Ishikawa, E; Uchida, G; Otsuka, H; Suzuki, H; Nishikawa, T; Ishida, T; Ishikawa, T; Furukawa, K; Funasaka, K; Ohno, E; Kawashima, H; Miyahara, R; Goto, H; Hirooka, Y

    GASTROINTESTINAL ENDOSCOPY   85 巻 ( 5 ) 頁: AB300 - AB300   2017年5月

  181. Objective Assessment of Jejunal Villous Blood Flow for Evaluating Pancreas-Jejunum Functional Correlation Using a Novel Image Analyzing System

    Takeyama, T; Hirooka, Y; Kawashima, H; Ohno, E; Ishikawa, T; Kawai, M; Suhara, H; Hashizume, K; Koya, T; Tanaka, H; Sakai, D; Matsushita, M; Yamamura, T; Furukawa, K; Funasaka, K; Nakamura, M; Miyahara, R; Watanabe, O; Goto, H

    GASTROINTESTINAL ENDOSCOPY   85 巻 ( 5 ) 頁: AB319 - AB320   2017年5月

  182. One Year Follow-Up After Cold Polypectomy Compared With Hot Polypectomy for Small Colorectal Polyps - a Prospective Randomized Controlled Trial

    Saito, M; Yamamura, T; Watanabe, O; Nakamura, M; Matsushita, M; Oshima, H; Sato, J; Matsuura, R; Mizutani, Y; Sawada, T; Niwa, Y; Ishikawa, E; Uchida, G; Otsuka, H; Suzuki, H; Nishikawa, T; Ishida, T; Ishikawa, T; Furukawa, K; Funasaka, K; Ohno, E; Kawashima, H; Miyahara, R; Goto, H; Hirooka, Y

    GASTROINTESTINAL ENDOSCOPY   85 巻 ( 5 ) 頁: AB365 - AB366   2017年5月

  183. Establishment of a New Scoring System for Predicting the Necessity of Double-Balloon Endoscopy in Obscure Gastrointestinal Bleeding

    Uchida, G; Watanabe, O; Nakamura, M; Yamamura, T; Matsushita, M; Oshima, H; Sato, J; Saito, M; Matsuura, R; Mizutani, Y; Sawada, T; Niwa, Y; Ishikawa, E; Otsuka, H; Suzuki, H; Nishikawa, T; Ishida, T; Ishikawa, T; Furukawa, K; Funasaka, K; Ohno, E; Kawashima, H; Miyahara, R; Goto, H; Hirooka, Y

    GASTROINTESTINAL ENDOSCOPY   85 巻 ( 5 ) 頁: AB300 - AB300   2017年5月

  184. Clinical Factors Related to False Positive Rates of Patency Capsule Examination

    Sawada, T; Nakamura, M; Watanabe, O; Yamamura, T; Matsushita, M; Oshima, H; Sato, J; Saito, M; Matsuura, R; Mizutani, Y; Niwa, Y; Ishikawa, E; Uchida, G; Otsuka, H; Suzuki, H; Nishikawa, T; Ishida, T; Ishikawa, T; Furukawa, K; Funasaka, K; Ohno, E; Miyahara, R; Kawashima, H; Goto, H; Hirooka, Y

    GASTROINTESTINAL ENDOSCOPY   85 巻 ( 5 ) 頁: AB305 - AB305   2017年5月

  185. Comparison of the diagnostic ability of blue laser imaging magnification versus pit pattern analysis for colorectal polyps.

    Nakano A, Hirooka Y, Yamamura T, Watanabe O, Nakamura M, Funasaka K, Ohno E, Kawashima H, Miyahara R, Goto H

    Endoscopy international open   5 巻 ( 4 ) 頁: E224 - E231   2017年4月

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    記述言語:英語  

    DOI: 10.1055/s-0043-102400

    PubMed

  186. Specific characteristics of hemorrhagic Meckel's diverticulum at double-balloon endoscopy.

    Mizutani Y, Nakamura M, Watanabe O, Yamamura T, Funasaka K, Ohno E, Kawashima H, Miyahara R, Murino A, Goto H Professor, Hirooka Y

    Endoscopy international open   5 巻 ( 1 ) 頁: E35 - E40   2017年1月

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    記述言語:英語  

    DOI: 10.1055/s-0042-119810

    PubMed

  187. Prospective study of factors important to achieve observation of the entire colon on colon capsule endoscopy

    Sato, J; Nakamura, M; Watanabe, O; Yamamura, T; Funasaka, K; Ohno, E; Miyahara, R; Kawashima, H; Goto, H; Hirooka, Y

    THERAPEUTIC ADVANCES IN GASTROENTEROLOGY   10 巻 ( 1 ) 頁: 20 - 31   2017年1月

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  188. Endoscopic Characteristics, Risk Grade, and Prognostic Prediction in Gastrointestinal Stromal Tumors of the Small Bowel

    Nakano, A; Nakamura, M; Watanabe, O; Yamamura, T; Funasaka, K; Ohno, E; Kawashima, H; Miyahara, R; Goto, H; Hirooka, Y

    DIGESTION   95 巻 ( 2 ) 頁: 122 - 131   2017年

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    記述言語:英語  

    DOI: 10.1159/000454728

    Web of Science

    PubMed

  189. Dexmedetomidine provides less body motion and respiratory depression during sedation in double-balloon enteroscopy than midazolam.

    Oshima H, Nakamura M, Watanabe O, Yamamura T, Funasaka K, Ohno E, Kawashima H, Miyahara R, Goto H, Hirooka Y

    SAGE open medicine   5 巻   頁: 2050312117729920   2017年

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    記述言語:英語  

    DOI: 10.1177/2050312117729920

    PubMed

  190. [Risk factors for rebleeding and risk-based follow-up of obscure gastrointestinal bleeding after its initial diagnosis].

    Uchida G, Nakamura M, Watanabe O, Yamamura T, Matsushita M, Ishikawa T, Furukawa K, Funasaka K, Ohno E, Kawashima H, Miyahara R, Goto H, Hirooka Y

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   114 巻 ( 10 ) 頁: 1819 - 1829   2017年

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    記述言語:日本語  

    DOI: 10.11405/nisshoshi.114.1819

    PubMed

  191. Effectiveness of Endoscopic Ultrasonography during Double Balloon Enteroscopy for characterization and management of small bowel submucosal tumours. 査読有り

    Murino A, Nakamura M, Watanabe O, Yamamura T, Nagura A, Yoshimura T, Nakano A, Goto H, Hirooka Y

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver   48 巻 ( 10 ) 頁: 1187-93   2016年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.dld.2016.06.026

    PubMed

  192. Evaluation of radiation exposure dose at double-balloon endoscopy for the patients with small bowel disease. 査読有り

    Nagura A, Nakamura M, Watanabe O, Yamamura T, Funasaka K, Ohno E, Miyahara R, Kawashima H, Koyama S, Hinami T, Goto H, Hirooka Y

    Nagoya journal of medical science   78 巻 ( 3 ) 頁: 245-53   2016年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PubMed

  193. Evaluation of the mRNA and Protein Expressions of Nutritional Biomarkers in the Gastrointestinal Mucosa of Patients with Small Intestinal Disorders. 査読有り

    Nakamura M, Hirooka Y, Watanabe O, Yamamura T, Funasaka K, Ohno E, Miyahara R, Kawashima H, Shimoyama Y, Goto H

    Internal medicine (Tokyo, Japan)   55 巻 ( 16 ) 頁: 2145-52   2016年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.55.6781

    PubMed

  194. A Retrospective Evaluation of the Utility of Capsule Endoscopy and Double-Balloon Endoscopy in Crohn's Disease. 査読有り

    Nakamura M, Hirooka Y, Watanabe O, Yamamura T, Funasaka K, Ohno E, Kawashima H, Miyahara R, Goto H

    Gastroenterology research and practice   2016 巻   頁: 1085027   2016年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1155/2016/1085027

    PubMed

  195. Utility of endoscopic diagnosis for postoperative small-bowel lesions in patients with Crohn's disease at double-balloon endoscopy. 査読有り

    Yamada K, Hirooka Y, Watanabe O, Nakamura M, Yamamura T, Funasaka K, Ohno E, Miyahara R, Kawashima H, Goto H

    Nagoya journal of medical science   77 巻 ( 3 ) 頁: 409-15   2015年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PubMed

  196. Clinical usefulness of novel tag-less Agile patency capsule prior to capsule endoscopy for patients with suspected small bowel stenosis. 査読有り

    Nakamura M, Hirooka Y, Yamamura T, Miyahara R, Watanabe O, Ando T, Ohmiya N, Goto H

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   27 巻 ( 1 ) 頁: 61-6   2015年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/den.12306

    PubMed

  197. Cowden syndrome complicated by a gastrointestinal stromal tumor. 査読有り

    Nakamura M, Hirooka Y, Yamamura T, Yamada K, Nagura A, Yoshimura T, Ohmiya N, Uehara K, Yoshioka Y, Nagino M, Goto H

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   26 巻 ( 5 ) 頁: 673-5   2014年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/den.12167

    PubMed

  198. Steroid-resistant Cronkhite-Canada syndrome successfully treated by cyclosporine and azathioprine. 査読有り

    Ohmiya N, Nakamura M, Yamamura T, Yamada K, Nagura A, Yoshimura T, Hirooka Y, Matsumoto T, Hirata I, Goto H

    Journal of clinical gastroenterology   48 巻 ( 5 ) 頁: 463-4   2014年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/MCG.0000000000000009

    PubMed

  199. Inhibition of Niemann-Pick-type C1-like1 by ezetimibe activates autophagy in human hepatocytes and reduces mutant α1-antitrypsin Z deposition. 査読有り

      59 巻 ( 4 ) 頁: 1591-9   2014年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/hep.26930

    PubMed

  200. Management of small-bowel polyps in Peutz-Jeghers syndrome by using enteroclysis, double-balloon enteroscopy, and videocapsule endoscopy. 査読有り

    Ohmiya N, Nakamura M, Takenaka H, Morishima K, Yamamura T, Ishihara M, Miyahara R, Kawashima H, Itoh A, Hirooka Y, Watanabe O, Ando T, Goto H

    Gastrointestinal endoscopy   72 巻 ( 6 ) 頁: 1209-16   2010年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.gie.2010.08.018

    PubMed

▼全件表示

講演・口頭発表等 10

  1. FACTORS RELATED TO MISSED COLORECTAL POLYPS ON COLON CAPSULE ENDOSCOPY IN CLINICAL PRACTICE

    Yamada Keisaku, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Otsuka Hiroyuki, Suzuki Hiroto, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hotta Naoki, Pu Leonardo Zorron Cheng Tao, Hirooka Yoshiki

    GASTROINTESTINAL ENDOSCOPY  2019年6月 

  2. USEFULLNESS OF EUS-GUIDED SHEAR-WAVE MEASUREMENT (EUS-SWM) FOR THE ASSESSMENT OF ACTIVITIES OF AUTOIMMUNE PANCREATITIS; A PROSPECTIVE EXPLORATORY STUDY

    Ohno Eizaburo, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya, Tanaka Hiroyuki, Sakai Daisuke, Iida Tadashi, Nishio Ryo, Suzuki Hirotaka, Uetsuki Kota, Yashika Jun, Yamada Kenta, Yoshikawa Masakatsu, Gibo Noriaki, Aoki Toshinori, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Miyahara Ryoji

    GASTROINTESTINAL ENDOSCOPY  2019年6月 

  3. The relationship between portal hypertension and the microbiome

    Yamamoto K., Honda T., Hattori S., Pu L. Zorron Cheng Tao, Ito T., Yamamura T., Ishizu Y., Kuzuya T., Ishigami M., Fujishiro M.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY  2019年9月 

  4. Specific members of gut microbiota predict mucosal healing in Crohn's disease

    Hattori S., Nakamura M., Yamamura T., Maeda K., Sawada T., Mizutani Y., Yamamoto K., Pu L. Zorron Cheng Tao, Honda T., Ishikawa T., Furukawa K., Ohno E., Miyahara R., Kawashima H., Fujishiro M.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY  2019年9月 

  5. Prospective study assessing a comprehensive computer-aided diagnosis for characterization of colorectal lesions: Results from different centers and imaging technologies

    Pu L. Zorron Cheng Tao, Maicas G., Tian Y., Yamamura T., Singh G., Rana K., Suzuki H., Nakamura M., Hirooka Y., Burt A., Fujishiro M., Carneiro G., Singh R.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY  2019年9月 

  6. PROSPECTIVE MULTICENTER STUDY ON THE USEFULNESS OF EUS-GUIDED FINE NEEDLE BIOPSY FOR THE DIAGNOSIS OF AUTOIMMUNE PANCREATITIS USING A 22-GAUGE FRANSEEN NEEDLE

    Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Nishio Ryo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Yamada Kenta, Yashika Jun, Yoshikawa Masakatsu, Gibo Noriaki, Aoki Toshinori, Kataoka Kunio, Mori Hiroshi, Keiko Maeda, Sawada Tsunaki, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Fujishiro Mitsuhiro

    GASTROINTESTINAL ENDOSCOPY  2020年6月 

  7. Modified Sano's classification is the most accurate for characterizing serrated polyps and adenomas with different virtual chromoendoscopy methods: Results of a prospective observational study

    Pu L. Zorron Cheng Tao, Yamamura T., Nakamura M., Koay D., Ovenden A., Edwards S., Hirooka Y., Burt A., Fujishiro M., Singh R.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY  2019年9月 

  8. Microbiota profile is markedly different for early and invasive colorectal cancer and is consistent throughout the colon

    Pu L. Zorron Cheng Tao, Yamamoto K., Honda T., Hattori S., Nakamura M., Yamamura T., Burt A., Hirooka Y., Singh R., Fujishiro M.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY  2019年9月 

  9. ENDOSCOPIC DIAGNOSIS USING MAGNIFYING IMAGE-ENHANCED ENDOSCOPY FOR SUPERFICIAL NON-AMPULLARY DUODENAL EPITHELIAL TUMORS

    Furukawa Kazuhiro, Miyahara Ryoji, Funasaka Kohei, Sawada Tsunaki, Keiko Maeda, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Fujishiro Mitsuhiro

    GASTROINTESTINAL ENDOSCOPY  2020年6月 

  10. Effect of training and time of the day on polyp detection rates

    Pu L. Zorron Cheng Tao, Lu K., Ovenden A., Rana K., Singh G., Krishnamurthi S., Edwards S., Wilson B., Nakamura M., Yamamura T., Ruszkiewicz A., Hoong C. K., Hirooka Y., Burt A. D., Singh R.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY  2018年9月 

▼全件表示

共同研究・競争的資金等の研究課題 1

  1. 大腸内視鏡における画像強調昨日LCI(Lincked color imaging)の有用性に関する臨床研究

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    担当区分:研究代表者  資金種別:競争的資金

科研費 3

  1. クローン病術後抗TNFα抗体維持療法の有効性と安全性に関する検討

    研究課題/研究課題番号:22K08768  2022年4月 - 2026年3月

    科学研究費助成事業  基盤研究(C)

    中山 吾郎, 山村 健史, 梅田 晋一, 中村 正直, 服部 憲史

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    担当区分:研究分担者 

    クローン病は小腸・大腸を中心とした消化管に慢性肉芽腫性炎症を生じる原因不明の炎症性腸疾患であり,厚生労働省より特定疾患(指定難病)に指定されている.現在クローン病を完治させる治療法はなく,薬物治療により活動性をコントロールし,患者のQoLを高めることが治療の主体である.一方で腸管切除を含む手術が必要となる症例も多く,また術後再発による再手術率が高いことは大きな問題である.本研究では難治性腸管病変に対する手術後の寛解維持療法としての生物学的製剤の再発抑制効果と安全性を臨床第2相試験として検証し,科学的根拠に基づく新たな治療戦略を創世することを目標とする.
    クローン病は小腸・大腸を中心とした消化管に慢性肉芽腫性炎症を生じる原因不明の炎症性腸疾患であり、厚生労働省より特定疾患に指定されている。現在クローン病を完治させる治療法はなく、薬物治療により活動性をコントロールし、患者のQoLを高めることが治療の主体である。一方で腸管切除を含む手術が必要となる症例も多く、また術後再発による再手術率が高いことは大きな問題である。本研究では難治性腸管病変に対する手術後の寛解維持療法としての生物学的製剤の再発抑制効果と安全性を臨床第2相試験として検証し、科学的根拠に基づく新たな治療戦略を創世することを目標とする。
    当施設の炎症性腸疾患治療センターを中心に内科・外科共同でクローン病の難治性腸管病変に対する術後ウステキヌマブ寛解維持療法の有効性と安全性について評価を行った。2022年度は、過去に当院でクローン病に対する腸管切除・吻合術後にウステキヌマブが投与された患者のうち、術前に抗TNF-α抗体薬の投与歴があるクローン病患者(コホートA)16例、術前に抗TNF-α抗体薬の投与歴がないクローン病患者(コホートB)11例を対象として、術後1年の臨床的再発に関して後方視的に検討を行い、本研究の妥当性について検討を行った。各コホートの再発率は、19%/10%と良好であり、この結果をもとに本研究の実施計画書を作成した。2023年度は研究実施計画書を名古屋大学医学部附属病院IRBへ提出し、認可を取得の上で症例登録を開始する(予定登録数50例)。
    2022年度は、本研究の妥当性の検証及び名古屋大学医学部附属病院IRBに提出する研究実施計画書作成を目的とし、historical dataを用いた後方視的検討を行い、本研究の実施計画書を作成した。
    2023年度は研究実施計画書を名古屋大学医学部附属病院IRBへ提出し、認可を取得の上で症例登録を開始する(予定登録数50例)。プロトコール治療(術後、2-4 週の期間にウステキヌマブを開始し、原則内視鏡的もしくは臨床的な再発が確認されるまで継続)及び内視鏡的評価を含むフォローアップは、研究代表者及び研究分担者を中心に実施する。2024年度には、主要評価項目である術後1年内視鏡的吻合部再発率について、2025年度には副次的評価項目(臨床的再発率,再手術率,各無再発生存期間,治療成功期間,有害事象発生割合等)について適宜評価・解析を行い、関連学会や論文において結果を公表する。

  2. 炎症性腸疾患における新規粘膜関連細菌叢検出法を用いた腸粘膜炎症プロファイルの作成

    研究課題/研究課題番号:20K07801  2020年4月 - 2024年3月

    科学研究費助成事業  基盤研究(C)

    中村 正直, 本多 隆, 山村 健史, 川嶋 啓揮, 藤城 光弘

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    担当区分:研究分担者 

    炎症性腸疾患の腸表面の粘膜関連細菌叢から粘膜固有層までの免疫増幅経路は同時に同部位で評価すべき事象である。同じ部位の内視鏡生検検体を用いて、A)粘膜関連細菌叢の最適検出法を見出したうえで採取、細菌16SrRNA次世代シークエンス解析を行う。B)生検組織のフローサイトメトリーによる免疫担当細胞とT細胞の分布解析、細胞内炎症性サイトカインの定量を行い、免疫応答をカテゴリー化する。C)粘膜内蛋白質量解析により、炎症反応のKeyとなる分子の量と種類につき網羅的に解析する。A)B)C)から得た結果を疾患活動性とリンクさせ、腸粘膜炎症プロファイルを作成する。
    20名の潰瘍性大腸炎患者において大腸内視鏡時に回腸末端、盲腸、直腸の生検組織、腸粘液を採取した検体について、腸炎の活動性と各炎症マーカー、神経ー免疫系にかかわる測定項目について既報を基に研究分担者と選定中である。
    追加で潰瘍性大腸炎患者3名の大腸内視鏡時における腸粘液をサンプルとし発症、再燃増悪に関連する因子の同定を目的とした。適切な検体採取の整合性を評価後、採取サンプル(炎症有無部位での比較)の網羅的解析を行った。独自の方法を用いて粘液層採取及びRNA抽出を行い、粘液層でのbulkのRNA seqを行った。ネットカテーテルによる粘液採取ではRNA抽出初期にネット自体が試薬内に溶け出し順調に進まなかったため、この実験は全てブラシ鉗子を用いて行った。腸粘液のRNAシークエンス実現性につき採取、抽出されたRNAの濃度、純度を測定しRNAシークエンスが可能と判断した。RNAシークエンスについてはraw dataから解析(QC, mapping, quantification, clustering, DE analysis, functional enrichment)を施行した際に神経伝達に関わる因子が複数指摘された。また我々の粘液層でのdata解析結果と、public dataの腸管上皮のRNA seqの解析結果を比較した。粘液層と腸管粘膜の網羅的解析結果を比較すると神経伝達に関連する因子が同定され、これらの因子が炎症に関与する可能性を考慮した。候補となった神経伝達因子については粘液内、粘膜内における存在をリアルタイムPCRで確認し、その各々が潰瘍性大腸炎の寛解期、活動期のいずれかで影響が大きいか調べた。
    大腸内視鏡によるサンプル採取方法の調整については、既報が無かったため時間を要し、更に測定項目の選定に時間を要したため全体の進行としてはやや遅れている。
    サンプル採取調整が終わり、現在はサンプル採取方法、実験系は確立できたため現在のペースで進めることができれば研究を完遂できると考えている。

  3. 焦点調節画像を用いた新規大腸腫瘍診断の解析と治療への応用

    研究課題/研究課題番号:19K20667  2019年4月 - 2024年3月

    科学研究費助成事業  若手研究

    山村 健史

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    担当区分:研究代表者 

    配分額:3770000円 ( 直接経費:2900000円 、 間接経費:870000円 )

    増加する大腸癌の診療において、大腸内視鏡は必要不可欠である。適切な診断と最適な治療方法を決定するために、狭帯域光観察(NBI)やpit pattern診断を高い正診率で行うことが重要であるが、主観に頼らざるを得ない内視鏡診断においては、診断能にバラツキが生じてしまう。本研究では、内視鏡画面全体に焦点の最適化を行った焦点調節画像を作成し、その特殊画像を用いることにより大腸腫瘍の診断能の向上を図る。また焦点調節画像を統合することにより、腫瘍の2Dマッピングや3D画像構築を行い内視鏡治療に活用することで治療成績の向上を図る。
    2019年度に様々な大腸腫瘍の内視鏡観察法で焦点調節画像を試し、白色光観察やpit pattern観察よりもImaged enhanced endoscopy拡大観察が最も本方法の条件に合致していると考えられた。また撮影法も動かす速度や画像の取り方などを色々と試し、最適な条件を決定した。
    次に撮影技術固定されたところで作成した焦点調節画像が内視鏡医に与える影響に関して検討した。具体的に作成した画像を動画と静止画単位で視認性や診断能の検討を行い、どこまで診断能が向上し得るかを評価した。初学者と熟練者に分け、それぞれを主観的評価と客観的評価に分けて検証した。その結果、客観的評価である診断精度(正診率など)は初学者と熟練者共に焦点調節画像になっても有意な改善は認めなかったが、主観的評価(読影結果の信頼度・画像の質の評価など)は両者で有意に改善した。また診断時間も同様に両者で改善した。以上より、焦点調節画像が内視鏡医に与える影響は主観的評価の向上であることが明らかとなった。これまでの結果については現在、論文投稿中である。
    3D構築については2020年度に試行したところ、画像を構築することは可能となった。ただし精密な図を作成するには、現技術ではまだ精度に問題があることが判明し、画像をマッチングさせる特徴点を大幅に増量し、それらを高速処理で処理時間を増やさない技術を名城大学と共同で開発していた。しかしコロナ蔓延による影響で相互の交流停止となる事情があり開発が遅れている。現在再度構築のプログラムを模索中である。
    3D構築については、前技術ではまだ精度に問題があり、評価は困難と判断した。動画の特徴点を大幅に増量し、それらを高速処理で処理時間を増やすことのない技術を名城大学と共同で開発しようとしているが、コロナ蔓延による活動停止時期などがあり十分な成果を得るに至っていない。現在は違うアプローチからの方法も模索している。
    現在、焦点調節画像が内視鏡医に与える影響に関しては成果を得ており論文投稿を進めている。
    今後の研究の方向としては、3D構築を可能とする方法の確立を目標としている。以前の画像をマッチングさせる特徴点を大幅に増量し、それらを高速処理で処理時間を増やすことなく3D構築を可能とする方法だと特徴点を合わせる部分で、対象の移動距離により正確性にやや難があることが分かった。ハレーションを除去する技術を進めたが、それ単独では良好な画像を作り出すことは困難であった。そのため特徴点を増やすことにより、同一物体のずれをより正確に感知し、3D化することを目指している。また別の方法も模索をしている。3D画像が構築可能となれば、実際の内視鏡手技において周囲(襞や蠕動による変形)との関係を3D画像構築することで、事前の有用な情報となりうる。