Updated on 2022/11/02

写真a

 
SUZUKI Nobuaki
 
Organization
Nagoya University Hospital Department of Blood Transfusion Service Lecturer
Graduate School
Graduate School of Medicine
Title
Lecturer

Degree 1

  1. 医学博士 ( 2013.9   名古屋大学 ) 

Research Areas 1

  1. Life Science / Hematology and medical oncology

Current Research Project and SDGs 1

  1. マウスモデルを用いた血液凝固異常症の病態解析

Research History 6

  1. Nagoya University Hospital   Department of Transfusion Medicine   Lecturer

    2021.5

  2. Nagoya University Hospital   Department of Transfusion Medicine   Assistant Professor

    2015.4 - 2021.4

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    Country:Japan

  3. 名古屋大学医学部附属病院   検査部   病院助教

    2014.4 - 2015.3

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    Country:Japan

  4. 名古屋大学医学部附属病院   検査部   医員 

    2011.4 - 2014.3

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    Country:Japan

  5. 大垣市民病院   血液内科   医員

    2007.4 - 2008.3

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    Country:Japan

  6. 国立名古屋病院 (現:名古屋医療センター)   研修医/血液内科レジデント

    2002.5 - 2007.3

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    Country:Japan

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Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    2007.4 - 2011.9

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    Country: Japan

  2. Hamamatsu University School of Medicine   Faculty of Medicine

    1996.4 - 2002.3

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    Country: Japan

Professional Memberships 4

  1. 日本輸血・細胞治療学会   評議員

    2021.4

  2. 日本血栓止血学会   代議員

    2013.9

  3. 日本血液学会

  4. 日本内科学会

Committee Memberships 1

  1.   日本血液学会 重篤副作用ガイドライン委員  

       

Awards 1

  1. 日本血液学会奨励賞

    2012.10   日本血液学会  

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    Country:Japan

 

Papers 41

  1. VWF-Gly2752Ser, a novel non-cysteine substitution variant in the CK domain, exhibits severe secretory impairment by hampering C-terminal dimer formation

    Okamoto Shuichi, Tamura Shogo, Sanda Naomi, Odaira Koya, Hayakawa Yuri, Mukaide Masato, Suzuki Atsuo, Kanematsu Takeshi, Hayakawa Fumihiko, Katsumi Akira, Kiyoi Hitoshi, Kojima Tetsuhito, Matsushita Tadashi, Suzuki Nobuaki

    JOURNAL OF THROMBOSIS AND HAEMOSTASIS   Vol. 20 ( 8 ) page: 1784 - 1796   2022.8

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  2. TSUBASA: A prospective study evaluating the association between physical activity and bleeding events in people with haemophilia A during emicizumab prophylaxis

    Fujii Teruhisa, Amano Kagehiro, Sawada Akihiro, Nagao Azusa, Nagae Chiai, Nojima Masanori, Suzuki Nobuaki, Nosaka Daisuke, Shimura Tomomi, Sugao Yoshimasa, Nogami Keiji

    HAEMOPHILIA   Vol. 28   page: 24 - 25   2022.5

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    Language:Japanese  

    Web of Science

  3. F9mRNA splicing aberration due to a deep Intronic structural variation in a patient with moderate hemophilia B

    Odaira Koya, Kawashima Fumika, Tamura Shogo, Suzuki Nobuaki, Tokoro Mahiru, Hayakawa Yuri, Suzuki Atsuo, Kanematsu Takeshi, Okamoto Shuichi, Takagi Akira, Katsumi Akira, Matsushita Tadashi, Shima Midori, Nogami Keiji, Kojima Tetsuhito, Hayakawa Fumihiko

    THROMBOSIS RESEARCH   Vol. 213   page: 91 - 96   2022.5

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  4. AKATSUKI study: a prospective, multicentre, phase IV study evaluating the safety of emicizumab under and immediately after immune tolerance induction therapy in persons with congenital haemophilia A with factor VIII inhibitors

    Matsushita Tadashi, Suzuki Nobuaki, Nagao Azusa, Nagae Chiai, Yamaguchi-Suita Haruko, Kyogoku Yui, Ioka Akiko, Nogami Keiji

    BMJ OPEN   Vol. 12 ( 3 ) page: e057018   2022.3

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  5. Protein S-Leu17Pro disrupts the hydrophobicity of its signal peptide causing a proteasome-dependent degradation

    Okada Kentaro, Tamura Shogo, Suzuki Nobuaki, Odaira Koya, Mukaide Masato, Fujii Wataru, Katsuragi Yumi, Suzuki Atsuo, Kanematsu Takeshi, Okamoto Shuichi, Suzuki Naruko, Katsumi Akira, Matsushita Tadashi, Kojima Tetsuhito, Hayakawa Fumihiko

    THROMBOSIS RESEARCH   Vol. 210   page: 26 - 32   2022.2

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  6. Development and validation of a novel qualitative test for plasma fibrinogen utilizing clot waveform analysis

    Suzuki Atsuo, Suzuki Nobuaki, Kanematsu Takeshi, Shinohara Sho, Kurono Hiroshi, Arai Nobuo, Okamoto Shuichi, Suzuki Naruko, Tamura Shogo, Kikuchi Ryosuke, Katsumi Akira, Kojima Tetsuhito, Matsushita Tadashi

    SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page: 434   2022.1

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  7. The influence of hepatitis C virus eradication on hepatocarcinogenesis in patients with hemophilia HCC after HCV eradication in hemophilia

    Inukai Yosuke, Imai Norihiro, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Honda Takashi, Okamoto Shuichi, Kanematsu Takeshi, Suzuki Nobuaki, Matsushita Tadashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    ANNALS OF HEPATOLOGY   Vol. 27 ( 1 ) page: 100545   2022

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  8. Tolerability of Molecular-targeted Agents for Hepatocellular Carcinoma Treatment in Haemophiliacs

    Yamamoto Takafumi, Imai Norihiro, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Honda Takashi, Okamoto Shuichi, Kanematsu Takeshi, Suzuki Nobuaki, Matsushita Tadashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    ANTICANCER RESEARCH   Vol. 41 ( 5 ) page: 2569 - 2573   2021.5

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  9. Essential role of a carboxyl-terminal alpha-helix motif in the secretion of coagulation factor XI

    Hayakawa Yuri, Tamura Shogo, Suzuki Nobuaki, Odaira Koya, Tokoro Mahiru, Kawashima Fumika, Hayakawa Fumihiko, Takagi Akira, Katsumi Akira, Suzuki Atsuo, Okamoto Shuichi, Kanematsu Takeshi, Matsushita Tadashi, Kojima Tetsuhito

    JOURNAL OF THROMBOSIS AND HAEMOSTASIS   Vol. 19 ( 4 ) page: 920 - 930   2021.4

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  10. Impact of variation in reagent combinations for one-stage clotting assay on assay discrepancy in nonsevere haemophilia A

    Suzuki Atsuo, Suzuki Nobuaki, Kanematsu Takeshi, Okamoto Shuichi, Tamura Shogo, Kikuchi Ryosuke, Katsumi Akira, Kiyoi Hitoshi, Kojima Tetsuhito, Matsushita Tadashi

    INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY   Vol. 43 ( 1 ) page: 131 - 138   2021.2

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  11. Myh9 R702C is associated with erythroid abnormality with splenomegaly in mice

    Kanematsu Takeshi, Suzuki Nobuaki, Tamura Shogo, Suzuki Atsuo, Ishikawa Yuichi, Katsumi Akira, Kiyoi Hitoshi, Saito Hidehiko, Kunishima Shinji, Kojima Tetsuhito, Matsushita Tadashi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 1 ) page: 75 - 86   2021.2

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  12. Safety and efficacy of percutaneous radiofrequency ablation for hepatocellular carcinoma patients with haemophilia

    Yamamoto Takafumi, Imai Norihiro, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Honda Takashi, Okamoto Shuichi, Kanematsu Takeshi, Suzuki Nobuaki, Matsushita Tadashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    HAEMOPHILIA   Vol. 27 ( 1 ) page: 100 - 107   2021.1

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  13. Aberrant X chromosomal rearrangement through multi-step template switching during sister chromatid formation in a patient with severe hemophilia A

    Tokoro Mahiru, Tamura Shogo, Suzuki Nobuaki, Kakihara Misaki, Hattori Yuna, Odaira Koya, Suzuki Sachiko, Takagi Akira, Katsumi Akira, Hayakawa Fumihiko, Okamoto Shuichi, Suzuki Atsuo, Kanematsu Takeshi, Matsushita Tadashi, Kojima Tetsuhito

    MOLECULAR GENETICS & GENOMIC MEDICINE   Vol. 8 ( 9 ) page: e1390   2020.9

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  14. Higher FVIII:C measured by chromogenic substrate assay than by one-stage assay is associated with silent hemophilic arthropathy

    Ogawa Mika, Suzuki Nobuaki, Takahashi Nobunori, Tamura Shogo, Suzuki Atsuo, Suzuki Sachiko, Hattori Yuua, Kakihara Misaki, Kanematsu Takeshi, Kojima Toshihisa, Katsumi Akira, Hayakawa Fumihiko, Kojima Tetsuhito, Ishiguro Naoki, Kiyoi Hitoshi, Matsushita Tadashi

    THROMBOSIS RESEARCH   Vol. 188   page: 103 - 105   2020.4

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  15. Successful Introduction of Peritoneal Dialysis in an End-stage Renal Failure Patient with Idiopathic Aplastic Anemia

    Suzuki Yasuhiro, Mizuno Masashi, Sakata Fumiko, Kojima Hiroshi, Sato Yuka, Kishimoto Mayuko, Suzuki Nobuaki, Kinashi Hiroshi, Saito Shoji, Katsuno Takayuki, Kosugi Tomoki, Maruyama Shoichi, Murata Makoto, Kiyoi Hitoshi, Ito Yasuhiko

    INTERNAL MEDICINE   Vol. 59 ( 5 ) page: 683 - 687   2020

  16. [Acquired coagulation disorders].

    Suzuki N

    [Rinsho ketsueki] The Japanese journal of clinical hematology   Vol. 61 ( 7 ) page: 779 - 784   2020

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    Language:Japanese  

    DOI: 10.11406/rinketsu.61.779

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  17. [Lupus anticoagulant-hypoprothrombinemia syndrome associated with follicular lymphoma].

    Koyama D, Hanajiri R, Kanematsu T, Ito R, Yamamoto S, Imoto N, Suzuki N, Kurahashi S, Sugiura I

    [Rinsho ketsueki] The Japanese journal of clinical hematology   Vol. 61 ( 7 ) page: 745 - 749   2020

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    DOI: 10.11406/rinketsu.61.745

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  18. Performance evaluation of Revohem((TM)) FVIII chromogenic and Revohem((TM)) FIX chromogenic in the CS-5100 autoanalyser

    Suzuki Atsuo, Suzuki Nobuaki, Kanematsu Takeshi, Shinohara Sho, Arai Nobuo, Kikuchi Ryosuke, Matsushita Tadashi

    INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY   Vol. 41 ( 5 ) page: 664 - 670   2019.10

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  19. Successful Perioperative Combination of High-Dose FVIII Therapy Followed by Emicizumab in a Patient with Hemophilia A with Inhibitors.

    Okamoto S, Suzuki N, Suzuki A, Suzuki S, Tamura S, Suzuki M, Takahashi N, Kojima T, Kanematsu T, Kojima T, Kiyoi H, Ishiguro N, Matsushita T

    TH open : companion journal to thrombosis and haemostasis   Vol. 3 ( 4 ) page: e364 - e366   2019.10

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    Language:English  

    DOI: 10.1055/s-0039-3401001

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  20. Ischaemic events are rare, and the prevalence of hypertension is not high in Japanese adults with haemophilia: First multicentre study in Asia

    Nagao Azusa, Suzuki Nobuaki, Takedani Hideyuki, Yamasaki Naoya, Chikasawa Yushi, Sawada Akihiro, Kanematsu Takeshi, Nojima Masanori, Higasa Satoshi, Amano Kagehiro, Fukutake Katsuyuki, Fujii Teruhisa, Matsushita Tadashi, Suzuki Takashi

    HAEMOPHILIA   Vol. 25 ( 4 ) page: E223 - E230   2019.7

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  21. Apparent synonymous mutation F9 c.87A > G causes secretion failure by in-frame mutation with aberrant splicing

    Odaira Koya, Tamura Shogo, Suzuki Nobuaki, Kakihara Misaki, Hattori Yuna, Tokoro Mahiru, Suzuki Sachiko, Takagi Akira, Katsumi Akira, Hayakawa Fumihiko, Okamoto Shuichi, Suzuki Atsuo, Kanematsu Takeshi, Matsushita Tadashi, Kojima Tetsuhito

    THROMBOSIS RESEARCH   Vol. 179   page: 95 - 103   2019.7

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  22. Molecular basis of SERPINC1 mutations in Japanese patients with antithrombin deficiency

    Tamura Shogo, Hashimoto Erika, Suzuki Nobuaki, Kakihara Misaki, Odaira Koya, Hattori Yuna, Tokoro Mahiru, Suzuki Sachiko, Takagi Akira, Katsumi Akira, Hayakawa Fumihiko, Suzuki Atsuo, Okamoto Shuichi, Kanematsu Takeshi, Matsushita Tadashi, Kojima Tetsuhito

    THROMBOSIS RESEARCH   Vol. 178   page: 159 - 170   2019.6

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  23. Clot waveform analysis in Clauss fibrinogen assay contributes to classification of fibrinogen disorders

    Suzuki Atsuo, Suzuki Nobuaki, Kanematsu Takeshi, Shinohara Sho, Arai Nobuo, Kikuchi Ryosuke, Matsushita Tadashi

    THROMBOSIS RESEARCH   Vol. 174   page: 98 - 103   2019.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.thromres.2018.12.018

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  24. Ischemic events are rare among aging patients with hemophilia: Results of a cross-sectional study from at centers treating hemophiliacs in Japan

    Suzuki Nobuaki, Takedani Hideyuki, Yamasaki Naoya, Chikasawa Yushi, Sawada Akihiro, Kanematsu Takeshi, Higasa Satoshi, Amano Kagehiro, Fukutake Katsuyuki, Nagao Azusa

    HAEMOPHILIA   Vol. 24   page: 13 - 14   2018.5

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  25. Vwf K1362A resulted in failure of protein synthesis in mice. Reviewed

    Sanda N, Suzuki N, Suzuki A, Kanematsu T, Kishimoto M, Hasuwa H, Takagi A, Kojima T, Matsushita T, Nakamura S

    Int J Hematol   Vol. 107 ( 4 ) page: 428 - 435   2018.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-017-2394-y

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  26. Combined deficiency of factors V and VIII by chance coinheritance of parahaemophilia and haemophilia A, but not by mutations of either LMAN1 or MCFD2, in a Japanese family. Reviewed

    Suzuki S, Nakamura Y, Suzuki N, Yamazaki T, Takagi Y, Tamura S, Takagi A, Kanematsu T, Matsushita T, Kojima T.

    Haemophilia   Vol. 24 ( 1 ) page: e13 - e16   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/hae.13360

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  27. Retrospective analysis of in vivo recovery and clearance during continuous infusion of recombinant factor VIII products: a single-institution study Reviewed

    Suzuki, N. Hirakawa, A. Kishimoto, M. Kanematsu, T. Ogawa, M. Kiyoi, H. Matsushita, T.

    Haemophilia   Vol. 23 ( 2 ) page: 215 - 221   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/hae.13082

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  28. Acquired immune-mediated von Willebrand syndrome accompanied by antiphospholipid syndrome.

    Kobayashi N, Ogawa Y, Yanagisawa K, Ishizaki T, Uchiumi H, Suzuki N, Matsushita T, Ichinose A, Handa H

    [Rinsho ketsueki] The Japanese journal of clinical hematology   Vol. 58 ( 6 ) page: 613-618   2017

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    DOI: 10.11406/rinketsu.58.613

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  29. The first case of antithrombin-resistant prothrombin Belgrade mutation in Japanese Reviewed

    Kishimoto, M. Suzuki, N. Murata, M. Ogawa, M. Kanematsu, T. Takagi, A. Kiyoi, H. Kojima, T. Matsushita, T.

    Ann Hematol   Vol. 95 ( 3 ) page: 541-2   2015.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  30. A case of MYH9 disorders caused by a novel mutation (p.K74E) Reviewed

    Kanematsu, T. Suzuki, N. Yoshida, T. Kishimoto, M. Aoki, T. Ogawa, M. Kagami, Y. Kiyoi, H. Matsushita, T. Kunishima, S.

    Ann Hematol   Vol. 95 ( 1 ) page: 161-3   2015.9

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  31. Acquired von Willebrand syndrome in a patient with immune thrombocytopenic purpura Reviewed

    Ihara, A. Suzuki, N. Matsushita, T. Ichinose, A.

    Rinsho Ketsueki   Vol. 56 ( 7 ) page: 901-4   2015.8

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  32. The features of clearance in recombinant factor IX (BeneFIX((R)) ) Reviewed

    Suzuki, N. Takedani, H. Hirakawa, A. Ushijima, Y. Matsushita, T.

    Haemophilia   Vol. 21 ( 5 ) page: 702-7   2015.4

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  33. Endoscopic treatment of esophageal varices in hemophiliac patients with liver cirrhosis Reviewed

    Ishizu, Y. Ishigami, M. Suzuki, N. Kuzuya, T. Honda, T. Hayashi, K. Katano, Y. Hirooka, Y. Ishikawa, T. Matsushita, T. Goto, H.

    Gastrointest Endosc   Vol. 81 ( 4 ) page: 1059-60   2015.3

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  34. Rhof promotes murine marginal zone B cell development Reviewed

    Kishimoto, M. Matsuda, T. Yanase, S. Katsumi, A. Suzuki, N. Ikejiri, M. Takagi, A. Ikawa, M. Kojima, T. Kunishima, S. Kiyoi, H. Naoe, T. Matsushita, T. Maruyama, M.

    Nagoya J Med Sci   Vol. 76 ( 3-4 ) page: 293-305   2015.3

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  35. Hepatectomy for hepatocellular carcinoma in patients with hemophilia Reviewed

    Inokawa, Y. Sugimoto, H. Kanda, M. Yamada, S. Fujii, T. Nomoto, S. Takeda, S. Suzuki, N. Matsushita, T. Kodera, Y.

    J Hepatobiliary Pancreat Sci   Vol. 21 ( 11 ) page: 824-8   2014.8

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  36. Animal models of MYH9 disorders Invited Reviewed

    Suzuki, N. Kunishima, S. Naoe, T. Matsushita, T.

    Rinsho Ketsueki   Vol. 54 ( 11 ) page: 2031-7   2013.12

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  37. Establishment of mouse model of MYH9 disorders: heterozygous R702C mutation provokes macrothrombocytopenia with leukocyte inclusion bodies, renal glomerulosclerosis and hearing disability Reviewed

    Suzuki, N. Kunishima, S. Ikejiri, M. Maruyama, S. Sone, M. Takagi, A. Ikawa, M. Okabe, M. Kojima, T. Saito, H. Naoe, T. Matsushita, T.

    PLoS One   Vol. 8 ( 8 ) page: e71187   2013.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  38. A possible mechanism for Inv22-related F8 large deletions in severe hemophilia A patients with high responding factor VIII inhibitors Reviewed

    Fujita, J. Miyawaki, Y. Suzuki, A. Maki, A. Okuyama, E. Murata, M. Takagi, A. Murate, T. Suzuki, N. Matsushita, T. Saito, H. Kojima, T.

    J Thromb Haemost   Vol. 10 ( 10 ) page: 2099-107   2012.8

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  39. Successful fertility management of a patient with factor V deficiency: planned transfusion of fresh frozen plasma under infertility treatment Reviewed

    Iwase, A. Goto, M. Manabe, S. Hirokawa, W. Kobayashi, H. Nakahara, T. Takikawa, S. Kotani, T. Sumigama, S. Tsuda, H. Nakayama, T. Suzuki, N. Matsushita, T. Kikkawa, F.

    Fertil Steril   Vol. 95 ( 6 ) page: 2124.e5-7   2011.2

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  40. Severe hemophilia A in a Japanese female caused by an F8-intron 22 inversion associated with skewed X chromosome inactivation Reviewed

    Miyawaki, Y. Suzuki, A. Fujimori, Y. Takagi, A. Murate, T. Suzuki, N. Katsumi, A. Naoe, T. Yamamoto, K. Matsushita, T. Takamatsu, J. Kojima, T.

    Int J Hematol   Vol. 92 ( 2 ) page: 405-8   2010.8

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  41. Heterozygous antithrombin deficiency improves in vivo haemostasis in factor VIII-deficient mice Reviewed

    Bolliger, D. Szlam, F. Suzuki, N. Matsushita, T. Tanaka, K. A.

    Thromb Haemost   Vol. 103 ( 6 ) page: 1233-8   2010.3

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Books 1

  1. 今日の治療指針

    鈴木伸明( Role: Contributor)

    医学書院  2020.1 

Research Project for Joint Research, Competitive Funding, etc. 6

  1. Factor V C2ドメイン異常がActivated Proein C Resistance(APCR)を引き起こすメカニズムの解明

    2017.4 - 2018.3

  2. アンチトロンビンレジスタンス(ATR)モデルマウスを用いた病態解析と血栓傾向評価アッセイの開発

    2016.12 - 2017.11

    小嶋哲人

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    2012年に、我々のグループは世界で初めて新規血栓性素因「アンチトロンビンレジスタンス (ATR)」を報告した(Miyawaki, NEJM, 2012)。本研究では、その原因遺伝子であるR593LをノックインしたATRモデルマウス(R593Lマウス)を用いて、その血栓性素因の詳細な病態解析を行うと同時に、Thrombin Generation Assay (TGA)やRotational thromboelastometry (ROTEM)を用いて、包括的に血栓傾向を評価するアッセイ系の構築を試みる。これらの研究は血液凝固の未知のメカニズム発見につながる可能性があり、かつマウスモデルを用いた血液凝固研究の発展に寄与する研究である

  3. von willebrand factor-血小板GPIb結合に着目した血栓制御

    2016.4 - 2017.3

    ノバルティスファーマ研究助成 

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    Grant type:Competitive

  4. von Willebrand Factor-血小板GPIb結合に着目した血栓制御

    2016.4 - 2017.3

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    血液凝固因子の一つであるvon Willebrand Factor (VWF)は血管内皮細胞、および巨核球で産生され、血漿、血小板および血管内皮細胞中に存在する。その役割は大きく二つあり、血小板表面のGPIbと結合することにより血小板凝集を惹起すること、血液凝固第VIII因子(FVIII)と結合し、FVIIIを安定化させることにより、止血に必要なFVIIIレベルを維持することである。先天的にVWFが欠乏するvon Willebrand disease (VWD)ではこれらの異常により、出血症状を呈する半面、VWFのノックアウトマウスを用いたFeCl3による血栓症モデルでは血小板血栓の形成をほとんど認めなかったという報告がある。このようなことから我々は虚血性心疾患の原因となる血小板性血栓の治療ターゲットとしてVWFに注目している。今回のプロジェクトではVWF, FVIIIの各ノックアウトマウスに加え、VWF K599A変異をノックインし、VWFと血小板 GPIbとの結合能が欠損するようにデザインされたオリジナルマウスを用いて、VWFと血小板GPIbの生体内での役割、および重要性について検討する。

  5. アンチトロンビンレジスタンス(ATR)モデルマウスを用いた病態解析と血栓傾向評価アッセイの開発

    2016 - 2017

    血液医学分野研究助成金 

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    Grant type:Competitive

  6. The mechanism of hemostasis in the treatment of von willebrand disease type III with inhibitor

    2012.4 - 2013.3

    Baxter Coagulation Research Fund(BCRF) 

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    Grant type:Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. ライフステージに伴う血小板・巨核球造血微小環境の時空間的変遷の解明

    Grant number:22K06881  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    田村 彰吾, 築地 長治, 鈴木 伸明

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    Authorship:Coinvestigator(s) 

    本研究は、申請者が発見した血小板・巨核球造血微小環境を形成する『骨髄PDPN陽性細網細胞』に着目し、骨髄PDPN陽性細網細胞の系譜解析によって早期ライフステージの血小板・巨核球造血微小環境の形成機構を明らかにする。さらに、骨髄PDPN陽性細網細胞の系統特異的ノックアウトマウスを作製し、早期ライフステージで生じる微小環境の変化が中期ライフステージ以降の血小板・巨核球造血に与える影響を解析する。

  2. 活性値の乖離に着目した血友病性関節症の病態解明とアンメットニーズの開拓

    Grant number:21K08388  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    鈴木 伸明, 高橋 伸典, 田村 彰吾, 鈴木 敦夫

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    血友病で欠損する凝固因子の活性測定法には凝固一段法(one stage assay:OSA)と合成基質法(chromogenic substrate assay:CSA)の二つの測定法があるが、測定法の違いにより値が乖離する症例が一定数存在する。最近申請者らが行った血友病Aを対象にした研究によりOSAよりもCSAの活性値が高い症例は関節内出血を未発症でも無自覚のうちに血友病性関節症を発症していたことが示された。本研究ではそのような患者さんの凝固学的異常メカニズムの検討と関節症が進行する病態検討を行い、血友病治療における最重要課題である関節症の発症メカニズム解明に取り組む。

  3. Identification of VWF-HBD in vascular growth and interaction with an inhibitory VEGF isoform

    Grant number:20K08711  2020.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s) 

  4. Prothrombin Mutants as a Potential Treatment for Hemophilia

    Grant number:18K16082  2018.4 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    Suzuki Nobuaki

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    Mice expressing a prothrombin mutant (R593L), which shows antithrombin resistance properties, showed a delayed thrombotic tendency, although their thrombin generation capacity was low. To evaluate whether this thrombogenic tendency contributes to the improvement of hemostasis, we generated hemophilia A mice expressing prothrombin R593L by crossing hemophilia A mice lacking coagulation factor VIII (which show bleeding tendency) and evaluated the effect of improving hemostasis in hemophilia A mice. However, no improvement was observed, indicating that the thrombogenic tendency does not necessarily contribute to the improvement of hemostasis. Based on these results, the application of this mutant to the treatment of hemophilia is considered to be ineffective at this stage.

  5. Therapeutic application of BOECs in von Willebrand disease

    Grant number:17K09902  2017.4 - 2020.3

    Matsushita Tadashi

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    Authorship:Coinvestigator(s) 

    In this study, we used Endothelial Colony forming cells (ECFC), which was obtained by culturing vascular endothelial progenitor cells (EPCs) isolated derived directly rom the peripheral blood of VWD patients. The effect of mutant VWF gene expression due to dominant-negative inheritance was intensively studied by immunofluorescence staining of ECFC and measurement of cell supernatant or lysate of the cells by ELISA. VWF release stimulated by DDAVP in ECFC was also studied, thereby the cytological VWF transport and secretion was observed. Based on our results, cytological background of the difference in the reactivity to DDAVP per each patient could be speculated.

  6. MYH9異常症の原因遺伝子であるR702C変異による赤血球分化阻害のメカニズム

    2014 - 2016

    科学研究費補助金  若手研究(B)

    鈴木伸明

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    Authorship:Principal investigator 

    メイ-ヘグリン異常に代表されるMYH9異常症は、非筋ミオシン重鎖IIA遺伝子であるMYH9変異により起こり、巨大血小板、血小板減少、顆粒球封入体を呈する。貧血など赤血球系統の異常の報告は無い。申請者らはヒトMYH9異常症症例、特にR702C変異症例での低ヘモグロビン値、低ヘマトクリット値を見いだした。一方、申請者らはR702C変異を持つノックインマウスの作製を行い、ヒトMYH9異常症に極めて類似した表現型を持つことを確認している。本研究では、MYH9異常症モデルマウスを用いて、赤血球造血障害の有無とその機序を明らかにする。

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Teaching Experience (On-campus) 8

  1. 医学入門

    2020

  2. 血液検査学Ⅱ

    2020

  3. 生涯健康と医学

    2020

  4. 臨床検査医学講義

    2020

  5. 血液病

    2020

  6. 医学入門

    2017

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    Human Biology, Sexually Transmitted Diseases

  7. 臨床検査医学講義

    2017

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    血液検査(血液形態、血液凝固)

  8. 血液病

    2017

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Media Coverage 1

  1. 血友病の今 Newspaper, magazine

    中日新聞  2020.2

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    Author:Other