国立名古屋病院 (現:名古屋医療センター)   研修医/血液内科レジデント

2002.5 - 2007.3

AKATSUKI 48-Week Interim Analysis: Emicizumab and Immune Tolerance Induction in People with Hemophilia A and Factor VIII Inhibitors

Matsushita, T; Suzuki, N; Nagae, C; Nagao, A; Ando, M; Kuwatsuka, Y; Nosaka, D; Kyogoku, Y; Shimura, T; Nogami, K

BLOOD   Vol. 142   2023.11

Haemophilia and cardiovascular disease in Japan: Low incidence rates from ADVANCE Japan baseline data

Nagao Azusa, Chikasawa Yushi, Sawada Akihiro, Kanematsu Takeshi, Yamasaki Naoya, Takedani Hideyuki, Nojima Masanori, Fujii Teruhisa, Suzuki Nobuaki, Matsushita Tadashi, Higasa Satoshi, Amano Kagehiro, ADVANCE Japan Working Grp

HAEMOPHILIA     2023.10

A prospective, multicenter, open-label phase III study of emicizumab prophylaxis in patients with acquired hemophilia A

Shima Midori, Amano Kagehiro, Ogawa Yoshiyuki, Yoneyama Koichiro, Ozaki Ryoto, Kobayashi Ryota, Sakaida Emiko, Saito Makoto, Okamura Takashi, Ito Toshihiro, Hattori Norimichi, Higasa Satoshi, Suzuki Nobuaki, Seki Yoshinobu, Nogami Keiji

JOURNAL OF THROMBOSIS AND HAEMOSTASIS   Vol. 21 ( 3 ) page： 534 - 545   2023.3

The usefulness of tranexamic acid for bleeding symptoms of chronic consumptive coagulopathy complicated by aortic disease: a single-institute, retrospective study of 14 patients

Suzuki Naruko, Suzuki Nobuaki, Kawaguchi Yuka, Okamoto Shuichi, Kanematsu Takeshi, Katsumi Akira, Suzuki Atsuo, Tamura Shogo, Kojima Tetsuhito, Kiyoi Hitoshi, Matsushita Tadashi

THROMBOSIS JOURNAL   Vol. 21 ( 1 ) page： 10   2023.1

The seroprevalence of neutralizing antibodies against the adeno-associated virus capsids in Japanese hemophiliacs

Kashiwakura Yuji, Baatartsogt Nemekhbayar, Yamazaki Shoji, Nagao Azusa, Amano Kagehiro, Suzuki Nobuaki, Matsushita Tadashi, Sawada Akihiro, Higasa Satoshi, Yamasaki Naoya, Fujii Teruhisa, Ogura Taemi, Takedani Hideyuki, Taki Masashi, Matsumoto Takeshi, Yamanouchi Jun, Sakai Michio, Nishikawa Masako, Yatomi Yutaka, Yada Koji, Nogami Keiji, Watano Ryota, Hiramoto Takafumi, Hayakawa Morisada, Kamoshita Nobuhiko, Kume Akihiro, Mizukami Hiroaki, Ishikawa Shizukiyo, Sakata Yoichi, Ohmori Tsukasa

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT   Vol. 27   page： 404 - 414   2022.12

Efficacy and Safety of Emicizumab Prophylaxis in Patients with Acquired Hemophilia a Who Were Deemed Ineligible for Immunosuppressive Therapy: Additional Data from the Ageha Study

Nishikii Hidekazu, Suzuki Nobuaki, Kobayashi Ryota, Mizuno Narumi, Ozaki Ryoto, Shima Midori

BLOOD   Vol. 140   page： 2724 - 2725   2022.11

VWF-Gly2752Ser, a novel non-cysteine substitution variant in the CK domain, exhibits severe secretory impairment by hampering C-terminal dimer formation

Okamoto Shuichi, Tamura Shogo, Sanda Naomi, Odaira Koya, Hayakawa Yuri, Mukaide Masato, Suzuki Atsuo, Kanematsu Takeshi, Hayakawa Fumihiko, Katsumi Akira, Kiyoi Hitoshi, Kojima Tetsuhito, Matsushita Tadashi, Suzuki Nobuaki

JOURNAL OF THROMBOSIS AND HAEMOSTASIS   Vol. 20 ( 8 ) page： 1784 - 1796   2022.8

TSUBASA: A prospective study evaluating the association between physical activity and bleeding events in people with haemophilia A during emicizumab prophylaxis

Fujii Teruhisa, Amano Kagehiro, Sawada Akihiro, Nagao Azusa, Nagae Chiai, Nojima Masanori, Suzuki Nobuaki, Nosaka Daisuke, Shimura Tomomi, Sugao Yoshimasa, Nogami Keiji

HAEMOPHILIA   Vol. 28   page： 24 - 25   2022.5

F9mRNA splicing aberration due to a deep Intronic structural variation in a patient with moderate hemophilia B

Odaira Koya, Kawashima Fumika, Tamura Shogo, Suzuki Nobuaki, Tokoro Mahiru, Hayakawa Yuri, Suzuki Atsuo, Kanematsu Takeshi, Okamoto Shuichi, Takagi Akira, Katsumi Akira, Matsushita Tadashi, Shima Midori, Nogami Keiji, Kojima Tetsuhito, Hayakawa Fumihiko

THROMBOSIS RESEARCH   Vol. 213   page： 91 - 96   2022.5

AKATSUKI study: a prospective, multicentre, phase IV study evaluating the safety of emicizumab under and immediately after immune tolerance induction therapy in persons with congenital haemophilia A with factor VIII inhibitors

Matsushita Tadashi, Suzuki Nobuaki, Nagao Azusa, Nagae Chiai, Yamaguchi-Suita Haruko, Kyogoku Yui, Ioka Akiko, Nogami Keiji

BMJ OPEN   Vol. 12 ( 3 ) page： e057018   2022.3

Protein S-Leu17Pro disrupts the hydrophobicity of its signal peptide causing a proteasome-dependent degradation

Okada Kentaro, Tamura Shogo, Suzuki Nobuaki, Odaira Koya, Mukaide Masato, Fujii Wataru, Katsuragi Yumi, Suzuki Atsuo, Kanematsu Takeshi, Okamoto Shuichi, Suzuki Naruko, Katsumi Akira, Matsushita Tadashi, Kojima Tetsuhito, Hayakawa Fumihiko

THROMBOSIS RESEARCH   Vol. 210   page： 26 - 32   2022.2

Development and validation of a novel qualitative test for plasma fibrinogen utilizing clot waveform analysis

Suzuki Atsuo, Suzuki Nobuaki, Kanematsu Takeshi, Shinohara Sho, Kurono Hiroshi, Arai Nobuo, Okamoto Shuichi, Suzuki Naruko, Tamura Shogo, Kikuchi Ryosuke, Katsumi Akira, Kojima Tetsuhito, Matsushita Tadashi

SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page： 434   2022.1

The influence of hepatitis C virus eradication on hepatocarcinogenesis in patients with hemophilia HCC after HCV eradication in hemophilia

Inukai Yosuke, Imai Norihiro, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Honda Takashi, Okamoto Shuichi, Kanematsu Takeshi, Suzuki Nobuaki, Matsushita Tadashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

ANNALS OF HEPATOLOGY   Vol. 27 ( 1 ) page： 100545   2022

Tolerability of Molecular-targeted Agents for Hepatocellular Carcinoma Treatment in Haemophiliacs

Yamamoto Takafumi, Imai Norihiro, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Honda Takashi, Okamoto Shuichi, Kanematsu Takeshi, Suzuki Nobuaki, Matsushita Tadashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

ANTICANCER RESEARCH   Vol. 41 ( 5 ) page： 2569 - 2573   2021.5

Essential role of a carboxyl-terminal α-helix motif in the secretion of coagulation factor XI

Hayakawa Yuri, Tamura Shogo, Suzuki Nobuaki, Odaira Koya, Tokoro Mahiru, Kawashima Fumika, Hayakawa Fumihiko, Takagi Akira, Katsumi Akira, Suzuki Atsuo, Okamoto Shuichi, Kanematsu Takeshi, Matsushita Tadashi, Kojima Tetsuhito

JOURNAL OF THROMBOSIS AND HAEMOSTASIS   Vol. 19 ( 4 ) page： 920 - 930   2021.4

Impact of variation in reagent combinations for one-stage clotting assay on assay discrepancy in nonsevere haemophilia A

Suzuki Atsuo, Suzuki Nobuaki, Kanematsu Takeshi, Okamoto Shuichi, Tamura Shogo, Kikuchi Ryosuke, Katsumi Akira, Kiyoi Hitoshi, Kojima Tetsuhito, Matsushita Tadashi

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY   Vol. 43 ( 1 ) page： 131 - 138   2021.2

Myh9 R702C is associated with erythroid abnormality with splenomegaly in mice

Kanematsu Takeshi, Suzuki Nobuaki, Tamura Shogo, Suzuki Atsuo, Ishikawa Yuichi, Katsumi Akira, Kiyoi Hitoshi, Saito Hidehiko, Kunishima Shinji, Kojima Tetsuhito, Matsushita Tadashi

NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 1 ) page： 75 - 86   2021.2

Safety and efficacy of percutaneous radiofrequency ablation for hepatocellular carcinoma patients with haemophilia

Yamamoto Takafumi, Imai Norihiro, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Honda Takashi, Okamoto Shuichi, Kanematsu Takeshi, Suzuki Nobuaki, Matsushita Tadashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

HAEMOPHILIA   Vol. 27 ( 1 ) page： 100 - 107   2021.1

Aberrant X chromosomal rearrangement through multi-step template switching during sister chromatid formation in a patient with severe hemophilia A

Tokoro Mahiru, Tamura Shogo, Suzuki Nobuaki, Kakihara Misaki, Hattori Yuna, Odaira Koya, Suzuki Sachiko, Takagi Akira, Katsumi Akira, Hayakawa Fumihiko, Okamoto Shuichi, Suzuki Atsuo, Kanematsu Takeshi, Matsushita Tadashi, Kojima Tetsuhito

MOLECULAR GENETICS & GENOMIC MEDICINE   Vol. 8 ( 9 ) page： e1390   2020.9

Higher FVIII:C measured by chromogenic substrate assay than by one-stage assay is associated with silent hemophilic arthropathy

Ogawa Mika, Suzuki Nobuaki, Takahashi Nobunori, Tamura Shogo, Suzuki Atsuo, Suzuki Sachiko, Hattori Yuua, Kakihara Misaki, Kanematsu Takeshi, Kojima Toshihisa, Katsumi Akira, Hayakawa Fumihiko, Kojima Tetsuhito, Ishiguro Naoki, Kiyoi Hitoshi, Matsushita Tadashi

THROMBOSIS RESEARCH   Vol. 188   page： 103 - 105   2020.4

Successful Introduction of Peritoneal Dialysis in an End-stage Renal Failure Patient with Idiopathic Aplastic Anemia

Suzuki Yasuhiro, Mizuno Masashi, Sakata Fumiko, Kojima Hiroshi, Sato Yuka, Kishimoto Mayuko, Suzuki Nobuaki, Kinashi Hiroshi, Saito Shoji, Katsuno Takayuki, Kosugi Tomoki, Maruyama Shoichi, Murata Makoto, Kiyoi Hitoshi, Ito Yasuhiko

INTERNAL MEDICINE   Vol. 59 ( 5 ) page： 683 - 687   2020

[Acquired coagulation disorders].

Suzuki N

[Rinsho ketsueki] The Japanese journal of clinical hematology   Vol. 61 ( 7 ) page： 779 - 784   2020

[Lupus anticoagulant-hypoprothrombinemia syndrome associated with follicular lymphoma].

Koyama D, Hanajiri R, Kanematsu T, Ito R, Yamamoto S, Imoto N, Suzuki N, Kurahashi S, Sugiura I

[Rinsho ketsueki] The Japanese journal of clinical hematology   Vol. 61 ( 7 ) page： 745 - 749   2020

Performance evaluation of Revohem<SUP>™</SUP> FVIII chromogenic and Revohem<SUP>™</SUP> FIX chromogenic in the CS-5100 autoanalyser

Suzuki Atsuo, Suzuki Nobuaki, Kanematsu Takeshi, Shinohara Sho, Arai Nobuo, Kikuchi Ryosuke, Matsushita Tadashi

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY   Vol. 41 ( 5 ) page： 664 - 670   2019.10

Successful Perioperative Combination of High-Dose FVIII Therapy Followed by Emicizumab in a Patient with Hemophilia A with Inhibitors.

Okamoto S, Suzuki N, Suzuki A, Suzuki S, Tamura S, Suzuki M, Takahashi N, Kojima T, Kanematsu T, Kojima T, Kiyoi H, Ishiguro N, Matsushita T

TH open : companion journal to thrombosis and haemostasis   Vol. 3 ( 4 ) page： e364 - e366   2019.10

Ischaemic events are rare, and the prevalence of hypertension is not high in Japanese adults with haemophilia: First multicentre study in Asia

Nagao Azusa, Suzuki Nobuaki, Takedani Hideyuki, Yamasaki Naoya, Chikasawa Yushi, Sawada Akihiro, Kanematsu Takeshi, Nojima Masanori, Higasa Satoshi, Amano Kagehiro, Fukutake Katsuyuki, Fujii Teruhisa, Matsushita Tadashi, Suzuki Takashi

HAEMOPHILIA   Vol. 25 ( 4 ) page： E223 - E230   2019.7

Apparent synonymous mutation F9 c.87A > G causes secretion failure by in-frame mutation with aberrant splicing

Odaira Koya, Tamura Shogo, Suzuki Nobuaki, Kakihara Misaki, Hattori Yuna, Tokoro Mahiru, Suzuki Sachiko, Takagi Akira, Katsumi Akira, Hayakawa Fumihiko, Okamoto Shuichi, Suzuki Atsuo, Kanematsu Takeshi, Matsushita Tadashi, Kojima Tetsuhito

THROMBOSIS RESEARCH   Vol. 179   page： 95 - 103   2019.7

Molecular basis of <i>SERPINC1</i> mutations in Japanese patients with antithrombin deficiency

Tamura Shogo, Hashimoto Erika, Suzuki Nobuaki, Kakihara Misaki, Odaira Koya, Hattori Yuna, Tokoro Mahiru, Suzuki Sachiko, Takagi Akira, Katsumi Akira, Hayakawa Fumihiko, Suzuki Atsuo, Okamoto Shuichi, Kanematsu Takeshi, Matsushita Tadashi, Kojima Tetsuhito

THROMBOSIS RESEARCH   Vol. 178   page： 159 - 170   2019.6

Clot waveform analysis in Clauss fibrinogen assay contributes to classification of fibrinogen disorders

Suzuki Atsuo, Suzuki Nobuaki, Kanematsu Takeshi, Shinohara Sho, Arai Nobuo, Kikuchi Ryosuke, Matsushita Tadashi

THROMBOSIS RESEARCH   Vol. 174   page： 98 - 103   2019.2

Ischemic events are rare among aging patients with hemophilia: Results of a cross-sectional study from at centers treating hemophiliacs in Japan

Suzuki Nobuaki, Takedani Hideyuki, Yamasaki Naoya, Chikasawa Yushi, Sawada Akihiro, Kanematsu Takeshi, Higasa Satoshi, Amano Kagehiro, Fukutake Katsuyuki, Nagao Azusa

HAEMOPHILIA   Vol. 24   page： 13 - 14   2018.5

Vwf K1362A resulted in failure of protein synthesis in mice. Reviewed

Sanda N, Suzuki N, Suzuki A, Kanematsu T, Kishimoto M, Hasuwa H, Takagi A, Kojima T, Matsushita T, Nakamura S

Int J Hematol   Vol. 107 ( 4 ) page： 428 - 435   2018.4

Combined deficiency of factors V and VIII by chance coinheritance of parahaemophilia and haemophilia A, but not by mutations of either LMAN1 or MCFD2, in a Japanese family. Reviewed

Suzuki S, Nakamura Y, Suzuki N, Yamazaki T, Takagi Y, Tamura S, Takagi A, Kanematsu T, Matsushita T, Kojima T.

Haemophilia   Vol. 24 ( 1 ) page： e13 - e16   2018.1

Retrospective analysis of in vivo recovery and clearance during continuous infusion of recombinant factor VIII products: a single-institution study Reviewed

Suzuki, N. Hirakawa, A. Kishimoto, M. Kanematsu, T. Ogawa, M. Kiyoi, H. Matsushita, T.

Haemophilia   Vol. 23 ( 2 ) page： 215 - 221   2017.3

Acquired immune-mediated von Willebrand syndrome accompanied by antiphospholipid syndrome.

Kobayashi N, Ogawa Y, Yanagisawa K, Ishizaki T, Uchiumi H, Suzuki N, Matsushita T, Ichinose A, Handa H

[Rinsho ketsueki] The Japanese journal of clinical hematology   Vol. 58 ( 6 ) page： 613-618   2017

The first case of antithrombin-resistant prothrombin Belgrade mutation in Japanese Reviewed

Kishimoto, M. Suzuki, N. Murata, M. Ogawa, M. Kanematsu, T. Takagi, A. Kiyoi, H. Kojima, T. Matsushita, T.

Ann Hematol   Vol. 95 ( 3 ) page： 541-2   2015.10

A case of MYH9 disorders caused by a novel mutation (p.K74E) Reviewed

Kanematsu, T. Suzuki, N. Yoshida, T. Kishimoto, M. Aoki, T. Ogawa, M. Kagami, Y. Kiyoi, H. Matsushita, T. Kunishima, S.

Ann Hematol   Vol. 95 ( 1 ) page： 161-3   2015.9

Acquired von Willebrand syndrome in a patient with immune thrombocytopenic purpura Reviewed

Ihara, A. Suzuki, N. Matsushita, T. Ichinose, A.

Rinsho Ketsueki   Vol. 56 ( 7 ) page： 901-4   2015.8

The features of clearance in recombinant factor IX (BeneFIX((R)) ) Reviewed

Suzuki, N. Takedani, H. Hirakawa, A. Ushijima, Y. Matsushita, T.

Haemophilia   Vol. 21 ( 5 ) page： 702-7   2015.4

Endoscopic treatment of esophageal varices in hemophiliac patients with liver cirrhosis Reviewed

Ishizu, Y. Ishigami, M. Suzuki, N. Kuzuya, T. Honda, T. Hayashi, K. Katano, Y. Hirooka, Y. Ishikawa, T. Matsushita, T. Goto, H.

Gastrointest Endosc   Vol. 81 ( 4 ) page： 1059-60   2015.3

Rhof promotes murine marginal zone B cell development Reviewed

Kishimoto, M. Matsuda, T. Yanase, S. Katsumi, A. Suzuki, N. Ikejiri, M. Takagi, A. Ikawa, M. Kojima, T. Kunishima, S. Kiyoi, H. Naoe, T. Matsushita, T. Maruyama, M.

Nagoya J Med Sci   Vol. 76 ( 3-4 ) page： 293-305   2015.3

Hepatectomy for hepatocellular carcinoma in patients with hemophilia Reviewed

Inokawa, Y. Sugimoto, H. Kanda, M. Yamada, S. Fujii, T. Nomoto, S. Takeda, S. Suzuki, N. Matsushita, T. Kodera, Y.

J Hepatobiliary Pancreat Sci   Vol. 21 ( 11 ) page： 824-8   2014.8

Animal models of MYH9 disorders Invited Reviewed

Suzuki, N. Kunishima, S. Naoe, T. Matsushita, T.

Rinsho Ketsueki   Vol. 54 ( 11 ) page： 2031-7   2013.12

Establishment of mouse model of MYH9 disorders: heterozygous R702C mutation provokes macrothrombocytopenia with leukocyte inclusion bodies, renal glomerulosclerosis and hearing disability Reviewed

Suzuki, N. Kunishima, S. Ikejiri, M. Maruyama, S. Sone, M. Takagi, A. Ikawa, M. Okabe, M. Kojima, T. Saito, H. Naoe, T. Matsushita, T.

PLoS One   Vol. 8 ( 8 ) page： e71187   2013.8

A possible mechanism for Inv22-related F8 large deletions in severe hemophilia A patients with high responding factor VIII inhibitors Reviewed

Fujita, J. Miyawaki, Y. Suzuki, A. Maki, A. Okuyama, E. Murata, M. Takagi, A. Murate, T. Suzuki, N. Matsushita, T. Saito, H. Kojima, T.

J Thromb Haemost   Vol. 10 ( 10 ) page： 2099-107   2012.8

Successful fertility management of a patient with factor V deficiency: planned transfusion of fresh frozen plasma under infertility treatment Reviewed

Iwase, A. Goto, M. Manabe, S. Hirokawa, W. Kobayashi, H. Nakahara, T. Takikawa, S. Kotani, T. Sumigama, S. Tsuda, H. Nakayama, T. Suzuki, N. Matsushita, T. Kikkawa, F.

Fertil Steril   Vol. 95 ( 6 ) page： 2124.e5-7   2011.2

Severe hemophilia A in a Japanese female caused by an F8-intron 22 inversion associated with skewed X chromosome inactivation Reviewed

Miyawaki, Y. Suzuki, A. Fujimori, Y. Takagi, A. Murate, T. Suzuki, N. Katsumi, A. Naoe, T. Yamamoto, K. Matsushita, T. Takamatsu, J. Kojima, T.

Int J Hematol   Vol. 92 ( 2 ) page： 405-8   2010.8

Heterozygous antithrombin deficiency improves in vivo haemostasis in factor VIII-deficient mice Reviewed

Bolliger, D. Szlam, F. Suzuki, N. Matsushita, T. Tanaka, K. A.

Thromb Haemost   Vol. 103 ( 6 ) page： 1233-8   2010.3

The mechanism of hemostasis in the treatment of von willebrand disease type III with inhibitor

2012.4 - 2013.3

Baxter Coagulation Research Fund(BCRF) 

Identification of VWF-HBD in vascular growth and interaction with an inhibitory VEGF isoform

Grant number：20K08711  2020.4 - 2023.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Prothrombin Mutants as a Potential Treatment for Hemophilia

Grant number：18K16082  2018.4 - 2021.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

Suzuki Nobuaki

Therapeutic application of BOECs in von Willebrand disease

Grant number：17K09902  2017.4 - 2020.3

Matsushita Tadashi

MYH9異常症の原因遺伝子であるR702C変異による赤血球分化阻害のメカニズム

2014 - 2016

科学研究費補助金  若手研究(B)

鈴木伸明

医学入門

2017

臨床検査医学講義

2017

血液病

2017