愛知県厚生連安城更生病院 外科医師

2006年6月 - 2007年3月

国立がんセンター中央病院 外科レジデント

2003年6月 - 2006年5月

名古屋大学医学部付属病院器官調節外科 医員

2003年5月

岐阜厚生連久美愛病院 外科医師

2002年4月 - 2003年4月

社会保険中京病院 嘱託専攻医

2000年4月 - 2002年3月

社会保険中京病院 臨床研修医

1998年5月 - 2000年3月

Efficacy of Extended Modification in Left Hemihepatectomy for Advanced Perihilar Cholangiocarcinoma: Comparison Between H12345'8'-B-MHV and H1234-B.

Otsuka S, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Shimoyama Y, Igami T, Uehara K, Yokoyama Y, Nagino M, Ebata T

Annals of surgery   277 巻 ( 3 ) 頁： e585 - e591   2023年3月

Cyclodextrin Conjugated α-Bisabolol Suppresses FAK Phosphorylation and Induces Apoptosis in Pancreatic Cancer.

Kano MT, Kokuryo T, Baba T, Yamazaki K, Yamaguchi J, Sunagawa M, Ogura A, Watanabe N, Onoe S, Miyata K, Mizuno T, Uehara K, Igami T, Yokoyama Y, Ebata T, Nagino M

Anticancer research   43 巻 ( 3 ) 頁： 1009 - 1016   2023年3月

Which modality is better to diagnose high-grade transformation in retroperitoneal liposarcoma? Comparison of computed tomography, positron emission tomography, and magnetic resonance imaging.

Nakashima Y, Yokoyama Y, Ogawa H, Sakakibara A, Sunagawa M, Nishida Y, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Kawakatsu S, Igami T, Ebata T

International journal of clinical oncology   28 巻 ( 3 ) 頁： 482 - 490   2023年3月

Impact of preoperative muscle mass and quality on surgical outcomes in patients undergoing major hepatectomy for perihilar cholangiocarcinoma.

Asai Y, Yamaguchi J, Mizuno T, Onoe S, Watanabe N, Igami T, Uehara K, Yokoyama Y, Ebata T

Journal of hepato-biliary-pancreatic sciences   30 巻 ( 2 ) 頁： 202 - 211   2023年2月

Antitumor Effects of Deep Ultraviolet Irradiation for Pancreatic Cancer.

Yamazaki K, Kokuryo T, Yamaguchi J, Sunagawa M, Ogura A, Watanabe N, Onoe S, Miyata K, Mizuno T, Uehara K, Igami T, Yokoyama Y, Ebata T, Nagino M

Anticancer research   43 巻 ( 2 ) 頁： 621 - 630   2023年2月

Minimum radial margin in pelvic exenteration for locally advanced or recurrent rectal cancer.

Aiba T, Uehara K, Tsuyuki Y, Ogura A, Murata Y, Mizuno T, Yamaguchi J, Kokuryo T, Yokoyama Y, Ebata T

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology   48 巻 ( 12 ) 頁： 2502 - 2508   2022年12月

Early volume loss of skeletal muscle after esophagectomy: a risk for late-onset postoperative pneumonia.

Nishimura K, Miyata K, Fukaya M, Yokoyama Y, Uehara K, Yamaguchi J, Mizuno T, Onoe S, Ogura A, Ebata T

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus   35 巻 ( 11 )   2022年11月

Is a specific T classification needed for extrahepatic intraductal papillary neoplasm of the bile duct (IPNB) type 2 associated with invasive carcinoma?

Mitake Y, Onoe S, Igami T, Mizuno T, Yamaguchi J, Sunagawa M, Watanabe N, Kawakatsu S, Shimoyama Y, Ebata T

Journal of hepato-biliary-pancreatic sciences     2022年11月

A proposal of drain removal criteria in hepatobiliary resection.

Watanabe N, Mizuno T, Yamaguchi J, Yokoyama Y, Igami T, Onoe S, Uehara K, Sunagawa M, Ebata T

Journal of hepato-biliary-pancreatic sciences   29 巻 ( 9 ) 頁： 974 - 982   2022年9月

Trefoil factor 1 inhibits the development of esophageal adenocarcinoma from Barrett's epithelium.

Hasebe K, Yamazaki K, Yamaguchi J, Kokuryo T, Yokoyama Y, Miyata K, Fukaya M, Nagino M, Ebata T

Laboratory investigation; a journal of technical methods and pathology   102 巻 ( 8 ) 頁： 885 - 895   2022年8月

Mild Prognostic Impact of Postoperative Complications on Long-term Survival of Perihilar Cholangiocarcinoma.

Kawakatsu S, Ebata T, Watanabe N, Onoe S, Yamaguchi J, Mizuno T, Igami T, Yokoyama Y, Matsuo K, Nagino M

Annals of surgery   276 巻 ( 1 ) 頁： 146 - 152   2022年7月

Superiority of clinical American Joint Committee on Cancer T classification for perihilar cholangiocarcinoma.

Yamada M, Mizuno T, Yamaguchi J, Yokoyama Y, Igami T, Onoe S, Watanabe N, Uehara K, Matsuo K, Ebata T

Journal of hepato-biliary-pancreatic sciences   29 巻 ( 7 ) 頁： 768 - 777   2022年7月

Results of a Phase II Study on the Use of Neoadjuvant Chemotherapy (FOLFIRINOX or GEM/nab-PTX) for Borderline-resectable Pancreatic Cancer (NUPAT-01).

Yamaguchi J, Yokoyama Y, Fujii T, Yamada S, Takami H, Kawashima H, Ohno E, Ishikawa T, Maeda O, Ogawa H, Kodera Y, Nagino M, Ebata T

Annals of surgery   275 巻 ( 6 ) 頁： 1043 - 1049   2022年6月

Combined Vascular Resection for Locally Advanced Perihilar Cholangiocarcinoma.

Mizuno T, Ebata T, Yokoyama Y, Igami T, Yamaguchi J, Onoe S, Watanabe N, Kamei Y, Nagino M

Annals of surgery   275 巻 ( 2 ) 頁： 382 - 390   2022年2月

A long-term survivor of advanced retroperitoneal dedifferentiated liposarcoma: a successful multimodal approach with extended resection and chemotherapy.

Nakahashi K, Yokoyama Y, Fukaya M, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Ebata T

Nagoya journal of medical science   84 巻 ( 1 ) 頁： 200 - 207   2022年2月

Predicting Inchinkoto efficacy, in patients with obstructive jaundice associated with malignant tumors, through pharmacomicrobiomics.

Yamashita H, Nishiyama M, Ohbuchi K, Kanno H, Tsuchiya K, Yamaguchi J, Mizuno T, Ebata T, Nagino M, Yokoyama Y

Pharmacological research   175 巻   頁： 105981   2022年1月

Trefoil factor family 2 inhibits cholangiocarcinogenesis by regulating the PTEN pathway in mice.

Hasebe K, Yamaguchi J, Kokuryo T, Yokoyama Y, Ochiai Y, Nagino M, Ebata T

Carcinogenesis   42 巻 ( 12 ) 頁： 1496 - 1505   2021年12月

A clinicopathological reappraisal of intraductal papillary neoplasm of the bile duct (IPNB): a continuous spectrum with papillary cholangiocarcinoma in 181 curatively resected cases.

Onoe S, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Watanabe N, Otsuka S, Nakamura S, Shimoyama Y, Nagino M

HPB : the official journal of the International Hepato Pancreato Biliary Association   23 巻 ( 10 ) 頁： 1525 - 1532   2021年10月

[Ⅱ.Treatment for Recurrent Cholangiocarcinoma].

Watanabe N, Yokoyama Y, Igami T, Uehara K, Mizuno T, Yamaguchi J, Miyata K, Onoe S, Ogura A, Ebata T

Gan to kagaku ryoho. Cancer & chemotherapy   48 巻 ( 10 ) 頁： 1223 - 1226   2021年10月

Adjuvant S-1 vs gemcitabine for node-positive perihilar cholangiocarcinoma: A propensity score-adjusted analysis.

Takahashi D, Mizuno T, Yokoyama Y, Igami T, Yamaguchi J, Onoe S, Watanabe N, Maeda O, Ando M, Ebata T

Journal of hepato-biliary-pancreatic sciences   28 巻 ( 9 ) 頁： 716 - 726   2021年9月

A presurgical prognostic stratification based on nutritional assessment and carbohydrate antigen 19-9 in pancreatic carcinoma: An approach with nonanatomic biomarkers.

Onoe S, Yokoyama Y, Kokuryo T, Igami T, Mizuno T, Yamaguchi J, Watanabe N, Kawakatsu S, Ebata T

Surgery   169 巻 ( 6 ) 頁： 1463 - 1470   2021年6月

Hepatopancreatoduodenectomy with simultaneous resection of the portal vein and hepatic artery for locally advanced cholangiocarcinoma: Short- and long-term outcomes of superextended surgery.

Nagino M, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N

Journal of hepato-biliary-pancreatic sciences   28 巻 ( 4 ) 頁： 376 - 386   2021年4月

A Study on Radial Margin Status in Resected Perihilar Cholangiocarcinoma.

Shinohara K, Ebata T, Shimoyama Y, Mizuno T, Yokoyama Y, Yamaguchi J, Onoe S, Watanabe N, Nagino M

Annals of surgery   273 巻 ( 3 ) 頁： 572 - 578   2021年3月

Application of fluorescent cholangiography during single-incision laparoscopic cholecystectomy in the cystohepatic duct without preoperative diagnosis.

Asai Y, Igami T, Ebata T, Yokoyama Y, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Nagino M

ANZ journal of surgery   91 巻 ( 3 ) 頁： 470 - 472   2021年3月

Impact of Preoperative Occult-Bacterial Translocation on Surgical Site Infection in Patients Undergoing Pancreatoduodenectomy.

Suenaga M, Yokoyama Y, Fujii T, Yamada S, Yamaguchi J, Hayashi M, Asahara T, Nagino M, Kodera Y

Journal of the American College of Surgeons   232 巻 ( 3 ) 頁： 298 - 306   2021年3月

Premalignant pancreatic cells seed stealth metastasis in distant organs in mice.

Yamaguchi J, Kokuryo T, Yokoyama Y, Ebata T, Ochiai Y, Nagino M

Oncogene   40 巻 ( 12 ) 頁： 2273 - 2284   2021年3月

Impact of the preoperative body composition indexes on intraoperative blood loss in patients undergoing pancreatoduodenectomy.

Ishii K, Yokoyama Y, Ebata T, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Nagino M

Surgery today   51 巻 ( 1 ) 頁： 52 - 60   2021年1月

Impact of Perioperative Steroid Administration in Patients Undergoing Major Hepatectomy with Extrahepatic Bile Duct Resection: A Randomized Controlled Trial.

Onoe S, Yokoyama Y, Ebata T, Igami T, Mizuno T, Yamaguchi J, Watanabe N, Suzuki S, Nishiwaki K, Ando M, Nagino M

Annals of surgical oncology   28 巻 ( 1 ) 頁： 121 - 130   2021年1月

Impact of Qualitative and Quantitative Biliary Contamination Status on the Incidence of Postoperative Infection Complications in Patients Undergoing Pancreatoduodenectomy.

Suenaga M, Yokoyama Y, Fujii T, Yamada S, Yamaguchi J, Hayashi M, Asahara T, Nagino M, Kodera Y

Annals of surgical oncology   28 巻 ( 1 ) 頁： 560 - 569   2021年1月

The influence of the preoperative thickness of the abdominal cavity on the gastrojejunal anatomic position and delayed gastric emptying after pancreatoduodenectomy.

Watanabe N, Yokoyama Y, Ebata T, Igami T, Mizuno T, Yamaguchi J, Onoe S, Nagino M

HPB : the official journal of the International Hepato Pancreato Biliary Association   22 巻 ( 12 ) 頁： 1695 - 1702   2020年12月

Study of the Portal Branches Arising from the Cranial Part of the Umbilical Portion of the Left Portal Vein: Implications for Anatomic Right Hepatic Trisectionectomy.

Minami T, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Nagino M

World journal of surgery   44 巻 ( 12 ) 頁： 4231 - 4235   2020年12月

How long should follow-up be continued after R0 resection of perihilar cholangiocarcinoma?

Nakahashi K, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Nagino M

Surgery   168 巻 ( 4 ) 頁： 617 - 624   2020年10月

Tumor marker recovery rather than major pathological response is a preferable prognostic factor in patients with pancreatic ductal adenocarcinoma with preoperative therapy.

Yamada S, Yokoyama Y, Sonohara F, Yamaguchi J, Takami H, Hayashi M, Onoe S, Fujii T, Nagino M, Kodera Y

Journal of hepato-biliary-pancreatic sciences   27 巻 ( 8 ) 頁： 487 - 495   2020年8月

Trefoil Factor Family 1 Inhibits the Development of Hepatocellular Carcinoma by Regulating β-Catenin Activation.

Ochiai Y, Yamaguchi J, Kokuryo T, Yokoyama Y, Ebata T, Nagino M

Hepatology (Baltimore, Md.)   72 巻 ( 2 ) 頁： 503 - 517   2020年8月

Postoperative infectious complications caused by multidrug-resistant pathogens in patients undergoing major hepatectomy with extrahepatic bile duct resection.

Sugawara G, Yokoyama Y, Ebata T, Igami T, Yamaguchi J, Mizuno T, Onoe S, Watanabe N, Nagino M

Surgery   167 巻 ( 6 ) 頁： 950 - 956   2020年6月

Study on the Segmentation of the Right Posterior Sector of the Liver.

Minami T, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Nagino M

World journal of surgery   44 巻 ( 3 ) 頁： 896 - 901   2020年3月

Predictive performance of Blumgart T staging for perihilar cholangiocarcinoma in a Japanese center.

Ebata T, Mizuno T, Yokoyama Y, Igami T, Yamaguchi J, Onoe S, Watanabe N, Nagino M

Journal of hepato-biliary-pancreatic sciences   27 巻 ( 3 ) 頁： 132 - 140   2020年3月

Postoperative Pancreatic Fistula in Surgery for Perihilar Cholangiocarcinoma.

Watanabe N, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Nagino M

World journal of surgery   43 巻 ( 12 ) 頁： 3094 - 3100   2019年12月

A case of small in situ perihilar cholangiocarcinoma incidentally accompanied by benign bile duct stricture after open cholecystectomy.

Maeda T, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Nagino M

Surgical case reports   5 巻 ( 1 ) 頁： 177   2019年11月

Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis.

Mizutani Y, Kobayashi H, Iida T, Asai N, Masamune A, Hara A, Esaki N, Ushida K, Mii S, Shiraki Y, Ando K, Weng L, Ishihara S, Ponik SM, Conklin MW, Haga H, Nagasaka A, Miyata T, Matsuyama M, Kobayashi T, Fujii T, Yamada S, Yamaguchi J, Wang T, Woods SL, Worthley D, Shimamura T, Fujishiro M, Hirooka Y, Enomoto A, Takahashi M

Cancer research   79 巻 ( 20 ) 頁： 5367 - 5381   2019年10月

Discrepancy between volume and functional recovery in early phase liver regeneration following extended hepatectomy with extrahepatic bile duct resection.

Maeda T, Yokoyama Y, Ebata T, Igami T, Mizuno T, Yamaguchi J, Onoe S, Ando M, Nagino M

Hepatology research : the official journal of the Japan Society of Hepatology   49 巻 ( 10 ) 頁： 1227 - 1235   2019年10月

Benign hilar bile duct strictures resected as perihilar cholangiocarcinoma.

Otsuka S, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Shimoyama Y, Nagino M

The British journal of surgery   106 巻 ( 11 ) 頁： 1504 - 1511   2019年10月

Occult synchronous liver metastasis from perihilar cholangiocarcinoma.

Ohiwa T, Ebata T, Mizuno T, Yokoyama Y, Yamaguchi J, Onoe S, Watanabe N, Nagino M

Surgery   166 巻 ( 3 ) 頁： 290 - 296   2019年9月

Cholangiographic Tumor Classification for Simple Patient Selection Prior to Hepatopancreatoduodenectomy for Cholangiocarcinoma.

Toyoda Y, Ebata T, Mizuno T, Yokoyama Y, Igami T, Yamaguchi J, Onoe S, Watanabe N, Nagino M

Annals of surgical oncology   26 巻 ( 9 ) 頁： 2971 - 2979   2019年9月

Preoperative course of patients undergoing endoscopic nasobiliary drainage during the management of resectable perihilar cholangiocarcinoma.

Maeda T, Ebata T, Yokoyama Y, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Kawashima H, Nagino M

Journal of hepato-biliary-pancreatic sciences   26 巻 ( 8 ) 頁： 341 - 347   2019年8月

Left trisectionectomy combined with resection of the right hepatic vein and inferior vena cava after right hepatic vein embolization for advanced intrahepatic cholangiocarcinoma.

Suzuki T, Ebata T, Yokoyama Y, Mizuno T, Igami T, Yamaguchi J, Onoe S, Watanabe N, Nagino M

Surgical case reports   5 巻 ( 1 ) 頁： 98   2019年6月

Is constant negative pressure for external drainage of the main pancreatic duct useful in preventing pancreatic fistula following pancreatoduodenectomy?

Sunagawa M, Yokoyama Y, Yamaguchi J, Ebata T, Sugawara G, Igami T, Mizuno T, Nagino M

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]   19 巻 ( 4 ) 頁： 602 - 607   2019年6月

Pleural dissemination of cholangiocarcinoma caused by percutaneous transhepatic biliary drainage during the management of resectable cholangiocarcinoma.

Yamashita H, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Ando M, Nagino M

Surgery   165 巻 ( 5 ) 頁： 912 - 917   2019年5月

NEK2 Is an Effective Target for Cancer Therapy With Potential to Induce Regression of Multiple Human Malignancies.

Kokuryo T, Yokoyama Y, Yamaguchi J, Tsunoda N, Ebata T, Nagino M

Anticancer research   39 巻 ( 5 ) 頁： 2251 - 2258   2019年5月

Phase II study of chemoradiotherapy combined with gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic ductal adenocarcinoma (NUPAT 05 Trial): study protocol for a single arm phase II study.

Takano N, Yamada S, Hirakawa A, Yokoyama Y, Kawashima H, Maeda O, Okada T, Ohno E, Yamaguchi J, Ishikawa T, Sonohara F, Suenaga M, Takami H, Hayashi M, Niwa Y, Hirooka Y, Ito Y, Naganawa S, Ando Y, Nagino M, Goto H, Fujii T, Kodera Y

Nagoya journal of medical science   81 巻 ( 2 ) 頁： 233 - 239   2019年5月

Major hepatectomy with or without pancreatoduodenectomy for advanced gallbladder cancer.

Mizuno T, Ebata T, Yokoyama Y, Igami T, Yamaguchi J, Onoe S, Watanabe N, Ando M, Nagino M

The British journal of surgery   106 巻 ( 5 ) 頁： 626 - 635   2019年4月

A case of human pancreatic eurytremiasis.

Ogawa H, Takehara Y, Naganawa S, Yamaguchi J, Nakaguro M

Abdominal radiology (New York)   44 巻 ( 4 ) 頁： 1213 - 1216   2019年4月

Pharmacokinetics of Nek2 siRNA in Peritoneal Dissemination of Pancreatic Cancer

Kokuryo T., Yamaguchi J., Yokoyama Y., Nagino M.

PANCREAS   48 巻 ( 10 ) 頁： 1465 - 1465   2019年

Trefoil Factor Family 1 (TFF1) Inhibits Epithelial-mesenchymal Transition and Enhances the Chemosensitivity of Pancreatic Ductal Adenocarcinoma (PDAC)

Yamaguchi J., Kokuryo T., Yokoyama Y., Ebata T., Nagino M.

PANCREAS   48 巻 ( 10 ) 頁： 1551 - 1552   2019年

Anti-tumor Effects of Deep Ultraviolet Irradiation for Pancreas Cancer

Yamazaki K., Kokuryo T., Yamaguchi J., Yokoyama Y., Nagino M.

PANCREAS   48 巻 ( 10 ) 頁： 1553 - 1553   2019年

Comparison between autologous and homologous blood transfusions in liver resection for biliary tract cancer: a propensity score matching analysis.

Onoe S, Yokoyama Y, Ebata T, Igami T, Mizuno T, Yamaguchi J, Watanabe N, Nagino M

Journal of hepato-biliary-pancreatic sciences   25 巻 ( 12 ) 頁： 550 - 559   2018年12月

Loss of trefoil factor 1 inhibits biliary regeneration but accelerates the hepatic differentiation of progenitor cells in mice.

Hayashi Y, Yamaguchi J, Kokuryo T, Ebata T, Yokoyama Y, Nagino M

Biochemical and biophysical research communications   506 巻 ( 1 ) 頁： 12 - 19   2018年11月

Surgery for perihilar cholangiocarcinoma from a viewpoint of age: Is it beneficial to octogenarians in an aging society?

Akashi K, Ebata T, Mizuno T, Yokoyama Y, Igami T, Yamaguchi J, Onoe S, Nagino M

Surgery   164 巻 ( 5 ) 頁： 1023 - 1029   2018年11月

Application of three-dimensional print in minor hepatectomy following liver partition between anterior and posterior sectors.

Igami T, Nakamura Y, Oda M, Tanaka H, Nojiri M, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Yamaguchi J, Mori K, Nagino M

ANZ journal of surgery   88 巻 ( 9 ) 頁： 882 - 885   2018年9月

Ethanol ablation for refractory bile leakage after complex hepatectomy.

Ito A, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Nagino M

The British journal of surgery   105 巻 ( 8 ) 頁： 1036 - 1043   2018年7月

Application of fluorescent cholangiography during single-incision laparoscopic cholecystectomy for cholecystitis with a right-sided round ligament: Preliminary experience.

Nojiri M, Igami T, Toyoda Y, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

Journal of minimal access surgery   14 巻 ( 3 ) 頁： 244 - 246   2018年7月

Preoperative biliary colonization/infection caused by multidrug-resistant (MDR) pathogens in patients undergoing major hepatectomy with extrahepatic bile duct resection.

Sugawara G, Yokoyama Y, Ebata T, Igami T, Yamaguchi J, Mizuno T, Yagi T, Nagino M

Surgery   163 巻 ( 5 ) 頁： 1106 - 1113   2018年5月

Impact of the gastrojejunal anatomic position as the mechanism of delayed gastric emptying after pancreatoduodenectomy.

Nojiri M, Yokoyama Y, Maeda T, Ebata T, Igami T, Sugawara G, Yamaguchi J, Nagino M

Surgery   163 巻 ( 5 ) 頁： 1063 - 1070   2018年5月

Phase I study of chemoradiotherapy using gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic cancer.

Yamada S, Fujii T, Yokoyama Y, Kawashima H, Maeda O, Suzuki K, Okada T, Ono E, Yamaguchi J, Takano N, Takami H, Hayashi M, Niwa Y, Hirooka Y, Ito Y, Naganawa S, Ando Y, Nagino M, Goto H, Kodera Y

Cancer chemotherapy and pharmacology   81 巻 ( 5 ) 頁： 815 - 821   2018年5月

Recurrence after curative-intent resection of perihilar cholangiocarcinoma: analysis of a large cohort with a close postoperative follow-up approach.

Komaya K, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

Surgery   163 巻 ( 4 ) 頁： 732 - 738   2018年4月

Pre-exposure to Fluorouracil Increased Trifluridine Incorporation and Enhanced its Anti-tumor Effect for Colorectal Cancer.

Baba T, Kokuryo T, Yamaguchi J, Yokoyama Y, Uehara K, Ebata T, Nagino M

Anticancer research   38 巻 ( 3 ) 頁： 1427 - 1434   2018年3月

Inhibition of Toll-like receptor 4 ameliorates experimental postischemic injury in the cholestatic liver through inhibition of high-mobility group box protein b1 (HMGB1) signaling.

Yokoi T, Yokoyama Y, Kokuryo T, Yamaguchi J, Nagino M

Surgery   163 巻 ( 2 ) 頁： 270 - 276   2018年2月

Does the intestinal microenvironment have an impact on the choleretic effect of inchinkoto, a hepatoprotective herbal medicine?

Uji M, Yokoyama Y, Asahara T, Ebata T, Igami T, Mizuno T, Yamaguchi J, Nagino M

Hepatology research : the official journal of the Japan Society of Hepatology   48 巻 ( 3 ) 頁： E303 - E310   2018年2月

Cells of Origin of Pancreatic Neoplasms 査読有り

Yamaguchi J, Yokoyama Y, Kokuryo T, Ebata T, Nagino M.

Surgery Today   48 巻 ( 1 ) 頁： 9-17   2018年1月

Cells of origin of pancreatic neoplasms.

Yamaguchi J, Yokoyama Y, Kokuryo T, Ebata T, Nagino M

Surgery today   48 巻 ( 1 ) 頁： 9 - 17   2018年1月

Single-Incision Laparoscopic Splenectomy for an Unruptured Aneurysm of the Splenic Artery.

Toyoda Y, Igami T, Ochiai Y, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

Medical principles and practice : international journal of the Kuwait University, Health Science Centre   27 巻 ( 1 ) 頁： 95 - 98   2018年

Successful local treatment for repeated hepatic recurrences of cholangiolocellular carcinoma: a report on a long-term survivor.

Shinohara K, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Shimoyama Y, Shiina S, Tateishi R, Arano T, Nagino M

Surgical case reports   3 巻 ( 1 ) 頁： 120   2017年12月

Occult mucin-producing cholangiocarcinoma in situ: a rare clinical case with difficult tumour staging.

Kiriyama M, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

Surgical case reports   3 巻 ( 1 ) 頁： 6   2017年12月

Long-term survival after multidisciplinary therapy for residual gallbladder cancer with peritoneal dissemination: a case report.

Kuga D, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

Surgical case reports   3 巻 ( 1 ) 頁： 76   2017年12月

Real-world experience with FOLFIRINOX and gemcitabine plus nab-paclitaxel in the treatment of pancreatic cancer in Japan

Maeda O., Yokoyama Y., Yamaguchi J., Ota A., Matsuoka A., Morita S., Inoue M., Mizutani T., Shimokata T., Urakawa H., Mitsuma A., Nagino M., Ando Y.

ANNALS OF ONCOLOGY   28 巻   頁： 69 - 69   2017年11月

Clinical influence of preoperative factor XIII activity in patients undergoing pancreatoduodenectomy.

Watanabe N, Yokoyama Y, Ebata T, Sugawara G, Igami T, Mizuno T, Yamaguchi J, Nagino M

HPB : the official journal of the International Hepato Pancreato Biliary Association   19 巻 ( 11 ) 頁： 972 - 977   2017年11月

The novel tumor suppressor Trefoil Factor Family 1 (TFF1) inhibits the development of hepatocellular carcinoma in mice

Yamaguchi Junpei, Yokoyama Yukihiro, Kokuryo Toshio, Ebata Tomoki, Nagino Masato

HEPATOLOGY   66 巻   頁： 981A-982A   2017年10月

Loss of trefoil factor 1 inhibits biliary regeneration but accelerates the differentiation of hepatic progenitors into hepatocytes in mice

Hayashi Yuki, Yamaguchi Junpei, Kokuryo Toshio, Ebata Tomoki, Yokoyama Yukihiro, Nagino Masato

HEPATOLOGY   66 巻   頁： 378A - 379A   2017年10月

Inhibition of Toll-Like Receptor 4 Ameliorates Experimental Post-Ischemic Injury in the Cholestatic Liver through Inhibition of High-Mobility Group Box Protein B1 (HMGB1) Signaling

Yokoi Tsuyoshi, Yokoyama Yukihiro, Kokuryo Toshio, Yamaguchi Junpei, Nagino Masato

HEPATOLOGY   66 巻   頁： 153A - 153A   2017年10月

Trefoil factor family 1 expression in the invasion front is a poor prognostic factor associated with lymph node metastasis in pancreatic cancer.

Sunagawa M, Yamaguchi J, Kokuryo T, Ebata T, Yokoyama Y, Sugawara G, Nagino M

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]   17 巻 ( 5 ) 頁： 782 - 787   2017年9月

Study on the segmentation of the right anterior sector of the liver.

Kobayashi T, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

Surgery   161 巻 ( 6 ) 頁： 1536 - 1542   2017年6月

Pulmonary Metastasis After Resection of Cholangiocarcinoma: Incidence, Resectability, and Survival.

Yamada M, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

World journal of surgery   41 巻 ( 6 ) 頁： 1550 - 1557   2017年6月

Novel therapy for pancreatic fistula using adipose-derived stem cell sheets treated with mannose.

Kaneko H, Kokuryo T, Yokoyama Y, Yamaguchi J, Yamamoto T, Shibata R, Gotoh M, Murohara T, Ito A, Nagino M

Surgery   161 巻 ( 6 ) 頁： 1561 - 1569   2017年6月

The development of an automatically produced cholangiography procedure using the reconstruction of portal-phase multidetector-row computed tomography images: preliminary experience.

Hirose T, Igami T, Koga K, Hayashi Y, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Yamaguchi J, Mori K, Nagino M

Surgery today   47 巻 ( 3 ) 頁： 365 - 374   2017年3月

Verification of the oncologic inferiority of percutaneous biliary drainage to endoscopic drainage: A propensity score matching analysis of resectable perihilar cholangiocarcinoma.

Komaya K, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

Surgery   161 巻 ( 2 ) 頁： 394 - 404   2017年2月

The Anticancer Effects of Novel α-Bisabolol Derivatives Against Pancreatic Cancer.

Murata Y, Kokuryo T, Yokoyama Y, Yamaguchi J, Miwa T, Shibuya M, Yamamoto Y, Nagino M

Anticancer research   37 巻 ( 2 ) 頁： 589 - 598   2017年2月

Surgery-Related Muscle Loss and Its Association with Postoperative Complications After Major Hepatectomy with Extrahepatic Bile Duct Resection.

Otsuji H, Yokoyama Y, Ebata T, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

World journal of surgery   41 巻 ( 2 ) 頁： 498 - 507   2017年2月

Anatomic features of independent right posterior portal vein variants: Implications for left hepatic trisectionectomy.

Watanabe N, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

Surgery   161 巻 ( 2 ) 頁： 347 - 354   2017年2月

Adjuvant gemcitabine monotherapy for resectable perihilar cholangiocarcinoma with lymph node involvement: a propensity score matching analysis.

Mizuno T, Ebata T, Yokoyama Y, Igami T, Sugawara G, Yamaguchi J, Nagino M

Surgery today   47 巻 ( 2 ) 頁： 182 - 192   2017年2月

Different Clinical Characteristics Between Distal Cholangiocarcinoma and Pancreatic Head Carcinoma With Biliary Obstruction

Yokoyama Yukihiro, Ebata Tomoki, Igami Tsuyoshi, Sugawara Gen, Mizuno Takashi, Yamaguchi Junpei, Nagino Masato

PANCREAS   46 巻 ( 10 ) 頁： 1322 - 1326   2017年

The Benefit of Extended Radical Surgery for Incidental Gallbladder Carcinoma 査読有り

Junpei Yamaguchi, Yuji Kaneoka, Atsuyuki Maeda, Yuichi Takayama, Shunsuke Onoe and Masatoshi Isogai

Surgery Today   46 巻   頁： 453-459   2016年

Positive surgical margins in surgically resected unifocal and multifocal IPMN 査読有り

Junpei Yamaguchi, Yuji Kaneoka, Atsuyuki Maeda, Yuichi Takayama, Shunsuke Onoe and Masatoshi Isogai

International Journal of Surgery   28 巻   頁： 51-55   2016年

Pancreatic duct gland (PDGs) are a progenitor compartment responsible for pancreatic ductal epithelial repair 査読有り

Junpei Yamaguchi, Andrew S. Liss, Alexandra Sontheimer, Mari Mino-Kenudson, Carlos Fernandez-del Castillo, Andrew L. Warshaw, Sarah P. Thayer

Stem Cell Research   15 巻   頁： 190-202   2015年

The role of histone deacetylase (HDAC) and EZH2 in oncogenesis: epigenetic silencing of tumor supressors 招待有り 査読有り

Junpei Yamaguchi, Motoko Sasaki and Yasuni Nakanuma

Tumor Suppressors     頁： 149-160   2011年

Papillary hyperplasia of the gallbladder in pancreaticobiliary maljunction represents a senescencerelated lesion induced by lysolecithin 査読有り

Junpei Yamaguchi, Motoko Sasaki, Kenichi Harada, Yoh Zen, Yasunori Sato, Hiroko Ikeda, Keita Itatsu, Yukihiro Yokoyama, Hisami Ando, Tetsuo Ohta, Akio Kubota, Koichi Shimizu, Yuji Nimura, Masato Nagino and Yasuni Nakanuma

laboratory investigation   89 巻   頁： 1018-1031   2009年

Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma 査読有り

Junpei Yamaguchi, Motoko Sasaki, Yasunori Sato, Keita Itatsu, Kenichi Harada, Yoh Zen, Hiroko Ikeda, Yuji Nimura, Masato Nagino and Yasuni Nakanuma

Cancer Science   101 巻 ( 2 ) 頁： 355-362   2009年

化学放射線療法による寛解導入後に胃癌が発見された2症例 招待有り 査読有り

山口淳平、片井均、佐野武、深川剛生、阪眞、井上昌也、笹子三津留、谷口浩和

日本消化器外科学会雑誌   41 巻 ( 9 ) 頁： 1682-1685   2008年

Spontaneous regression of inflammatory pseudotumor of the liver: three case reports 査読有り

Junpei Yamaguchi, Yoshihiro Sakamoto, Tsuyoshi Sano, Kazuaki Shimada, Tomoo Kosuge

surgery today   37 巻 ( 6 ) 頁： 525-529   2007年

高アルドステロン血症と耐糖能異常を合併した若年者肝細胞癌の一例 招待有り 査読有り

山口淳平、佐野力、島田和明、阪本良弘、奈良聡、小菅智男

日本消化器外科学会雑誌   40 巻 ( 5 ) 頁： 611-616   2007年

A case of mucinous carcinoma of the breast that demonstrated a good pathological response to neoadjuvant chemotherapy despite a poor clinacal response 査読有り

Junpei Yamaguchi, Sadako Akashi-Tanaka, Takayoshi Fukutomi, Takayuki Kinoshita, Eriko Iwamoto, Miyuki Takasugi

Breast Cancer   13 巻 ( 1 ) 頁： 100-103   2006年

A case of mucinous cystic tumor of the pancreatic tail 査読有り

Junpei Yamaguchi, Yoshihiro Sakamoto

Japanese Journal of Clinical Oncology   36 巻 ( 1 ) 頁： 65   2006年

Poorly differentiated hepatocellular carcinoma with unusual tubular structures 査読有り

Junpei Yamaguchi, Hidenori Ojima, Nobuyoshi Hiraoka, Tadashi Hasegawa

Journal of Clinical Pathology   58 巻   頁： 1342   2005年

TFF1による膵発癌抑制機構の検討

山口淳平、江畑智希、横山幸浩、國料俊男、伊神剛、水野隆史、尾上俊介、渡辺伸元

日本外科学会定期学術集会  2019年4月 

Trefoil Factor 1 inhibits epithelial-mesenchymal transition (EMT) of pancreatic intraepithelial neoplasm. 国際会議

Junpei Yamaguchi, Yukihiro Yokoyama, Toshio Kokuryo and Masato Nagino

AACR Pancreatic cancer: advances in science and clinical care  2018年9月 

The novel tumor suppressor Trefoil Factor Family 1 (TFF1) inhibits the development of hepatocellular carcinoma in mice 国際会議

Junpei Yamaguchi, Yukihiro Yokoyama, Toshio Kokuryo and Masato Nagino

AASLD the Liver Meeting 2017  2017年10月 

遺伝子改変マウスを用いたTFF1欠損による膵浸潤癌発生に関する検討

山口淳平、江畑智希、横山幸浩、國料俊男、梛野正人

第48回日本膵臓学会大会  2017年7月 

Preserved expression of TFF1 in invasive front is a poor prognostic factor in PDAC 国際会議

Junpei Yamaguchi, Masaki Sunagawa, Yukihiro yokoyama, Toshio Kokuryo, Tomoki Ebata, Masato Nagino

Joint Congress of The 6th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association &　The 29th Meeting of Japanese Society of Hepato-Biliary-Pancreatic Surgery  2017年6月 

TFF1 (Trefoil Factor Family 1) act as tumor suppressor to inhibit invasive transformation of PanIN into PDAC in vivo 国際会議

Junpei Yamaguchi, Yukihiro Yokoyama, Toshio Kokuryo and Masato Nagino

47th APA annual meeting 

The tumor suppressive role of TFF (Trefoil Factor Family) in pancreatic carcinogenesis 国際会議

Junpei Yamaguchi, Yukihiro Yokoyama, Toshio Kokuryo and Masato Nagino

20th meeting of IAP, 6th meeting of AOPA 

TFF (Trefoil Factor Family) is a novel tumor suppressor and can be the therapeutic target for pancreatic cancer 国際会議

Junpei Yamaguchi, Yukihiro Yokoyama, Toshio Kokuryo and Masato Nagino

An AACR Special Conference on Pancreatic Cancer 

TFF1 (Trefoil Factor Family 1) act as tumor suppressor to prevent invasive transformation of pancreatic cancer 国際会議

膵癌に対するTrefoil Factor Family 2 (TFF2)の抗腫瘍効果の検討 国際会議

山口淳平、S.P. Thayer, A.L. Warshaw、江畑智希、横山幸弘、國料俊男、伊神剛、菅原元、水野隆司、梛野正人

日本消化器外科学会総会 

膵癌抑制因子としてのTrefoil Factor Family 1 (TFF1)の役割の検討 国際会議

山口淳平、江畑智希、横山幸弘、國料俊男、伊神剛、菅原元、水野隆司、梛野正人

日本肝胆膵外科学会学術集会 

Trefoil Family Factor 2 (TFF2)抑制による膵IPMN発生マウスモデルの検討 国際会議

山口淳平、S.P. Thayer, A.L. Warshaw、江畑智希、横山幸弘、國料俊男、梛野正人

日本外科学会定期学術集会 

Trefoil Factor Family 1 (TFF1) Inhibit the Invasion of Tumor Cells of the Pancreas 国際会議

Junpei Yamaguchi, Toshio Kokuryo, Yukihiro Yokoyama and Masato Nagino

Experimantal Biology 2015 

当院におけるIPMN切除例55例の治療成績の検討

山口淳平、磯谷正敏、原田徹、金岡祐次、亀井桂太郎、前田敦行、高山祐一、川勝章司、大塚新平、森治樹、米川佳彦、掘米香世子、渡辺夕樹、千馬耕亮

日本肝胆膵外科学会 

当院におけるIncidental Gallbladder Carcinomaに対する追加切除とその予後の検討

山口淳平、磯谷正敏、原田徹、金岡祐次、亀井桂太郎、前田敦行、高山祐一、川勝章司、大塚新平、森治樹、米川佳彦、掘米香世子、渡辺夕樹、千馬耕亮

日本臨床外科学会総会 

Loss of TFF2 in Pancreatic Duct Glands (PDG) results in the formation of IPMN suggesting TFF2 may function as tumor suppressor. 国際会議

Pancreatic Duct Glands (PDG), a Progenitor Stem Cell Niche Responsible for Pancreatic Epithelial Renewal and Repair in Response to Inflammatory Injury 国際会議

Pancreatic Duct Glands (PDG) Are the Origin of Gastric-Type IPMN 国際会議

Pancreatic Duct Glands (PDG), a Progenitor Stem Cell Niche Responsible for Pancreatic Epithelial Renewal 国際会議

Pancreati Duct Glands (PDG) Are the Origin of Gastric-type IPMN 国際会議

膵胆管合流異常症胆嚢における前癌病変と細胞老化機構の関与

山口淳平、佐々木素子、原田憲一、佐藤保則、池田博子、梛野正人、中沼安二

日本外科学会定期学術集会 

ヒストン脱アセチル化酵素阻害剤(SAHA)およびEZH2抑制による胆嚢癌増殖抑制効果

山口淳平、佐々木素子、原田憲一、佐藤保則、池田博子、梛野正人、中沼安二

日本胆道学会学術集会 

胆嚢前癌病変における細胞老化機構の関与

山口淳平、佐々木素子、原田憲一、佐藤保則、池田博子、板津慶太、梛野正人、中沼安二

日本胆道学会学術集会 

胆嚢前癌病変における細胞老化の関与

山口淳平、佐々木素子、原田憲一、佐藤保則、池田博子、中沼安二

日本病理学会総会 

高アルドステロン血症と耐糖能異常を合併した若年者肝細胞癌の一例

山口淳平、佐野力、島田和明、阪本良弘、奈良聡、小菅智男

日本消化器外科学会定期学術総会 

Invisible膵癌に対する新規診断治療法の開発

研究課題/研究課題番号：19K09168  2019年4月 - 2022年3月

科学研究費助成事業  基盤研究(C)

渡辺 伸元, 梛野 正人, 江畑 智希, 横山 幸浩, 國料 俊男, 山口 淳平

Trefoil Factorと肝発癌の関連および肝癌新規治療法開発に関する研究

研究課題/研究課題番号：19K09141  2019年4月 - 2022年3月

科学研究費助成事業  基盤研究(C)

江畑 智希, 山口 淳平, 梛野 正人, 國料 俊男, 横山 幸浩

血中循環腫瘍細胞の生着および非対称分裂・自己組織化に対する癌転移抑制法の開発

研究課題/研究課題番号：19K09142  2019年4月 - 2021年3月

科学研究費助成事業  基盤研究(C)

相場 利貞, 梛野 正人, 江畑 智希, 横山 幸浩, 國料 俊男, 山口 淳平, 上原 圭介

胆管癌融合遺伝子を標的にした新規核酸医薬の開発

研究課題/研究課題番号：18H02879  2018年4月 - 2022年3月

科学研究費助成事業  基盤研究(B)

梛野 正人, 山口 淳平, 江畑 智希, 國料 俊男

肝切除のためのリアルタイムナビゲーションシステムの開発

研究課題/研究課題番号：18K08644  2018年4月 - 2021年3月

科学研究費助成事業  基盤研究(C)

伊神 剛, 梛野 正人, 江畑 智希, 國料 俊男, 山口 淳平

Trefoil Factorを軸としたBarrett食道発癌機序の解明

研究課題/研究課題番号：18K08699  2018年4月 - 2021年3月

科学研究費助成事業  基盤研究(C)

深谷 昌秀, 梛野 正人, 國料 俊男, 山口 淳平

深紫外線による新規癌治療法の開発

研究課題/研究課題番号：18K08673  2018年4月 - 2021年3月

科学研究費助成事業  基盤研究(C)

宮田 一志, 梛野 正人, 江畑 智希, 國料 俊男, 山口 淳平

TFF1の膵癌抑制効果の検証と膵癌治療に対する有用性の検討

研究課題/研究課題番号：17K10695  2017年4月 - 2020年3月

山口 淳平

術後肝障害に対するTLR4を標的にした予防治療法の開発

研究課題/研究課題番号：17K10667  2017年4月 - 2018年3月

菅原 元

癌幹細胞に対する新規治療戦略

研究課題/研究課題番号：16K10454  2016年4月 - 2019年3月

角田 伸行

Pre-metastatic nicheを制御する新規転移抑制治療法の開発

研究課題/研究課題番号：16K10568  2016年4月 - 2019年3月

水野 隆史

TLR7を標的にした新規癌治療法における作用機序の解明

研究課題/研究課題番号：16K10531  2016年4月 - 2019年3月

上原 圭介

システインの肝障害抑制に関する作用機序の解明

研究課題/研究課題番号：16K10567  2016年4月 - 2019年3月

横山 幸浩

ビサボロール誘導体の作用機序の解明と臨床応用

研究課題/研究課題番号：16K10591  2016年4月 - 2019年3月

國料 俊男

術後感染性合併症に対するRAGE活性化機序の解明と治療法の開発

研究課題/研究課題番号：15K10092  2015年4月 - 2018年3月

深谷 昌秀

膵癌に対する腫瘍抑制因子としてのTFF2の検討

2014年4月 - 2016年3月

科学研究費補助金  研究活動スタート支援