愛知県厚生連安城更生病院 外科医師

2006.6 - 2007.3

国立がんセンター中央病院 外科レジデント

2003.6 - 2006.5

名古屋大学医学部付属病院器官調節外科 医員

2003.5

岐阜厚生連久美愛病院 外科医師

2002.4 - 2003.4

社会保険中京病院 嘱託専攻医

2000.4 - 2002.3

社会保険中京病院 臨床研修医

1998.5 - 2000.3

Efficacy of Extended Modification in Left Hemihepatectomy for Advanced Perihilar Cholangiocarcinoma: Comparison Between H12345'8'-B-MHV and H1234-B.

Otsuka S, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Shimoyama Y, Igami T, Uehara K, Yokoyama Y, Nagino M, Ebata T

Annals of surgery   Vol. 277 ( 3 ) page： e585 - e591   2023.3

Cyclodextrin Conjugated α-Bisabolol Suppresses FAK Phosphorylation and Induces Apoptosis in Pancreatic Cancer.

Kano MT, Kokuryo T, Baba T, Yamazaki K, Yamaguchi J, Sunagawa M, Ogura A, Watanabe N, Onoe S, Miyata K, Mizuno T, Uehara K, Igami T, Yokoyama Y, Ebata T, Nagino M

Anticancer research   Vol. 43 ( 3 ) page： 1009 - 1016   2023.3

Which modality is better to diagnose high-grade transformation in retroperitoneal liposarcoma? Comparison of computed tomography, positron emission tomography, and magnetic resonance imaging.

Nakashima Y, Yokoyama Y, Ogawa H, Sakakibara A, Sunagawa M, Nishida Y, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Kawakatsu S, Igami T, Ebata T

International journal of clinical oncology   Vol. 28 ( 3 ) page： 482 - 490   2023.3

Impact of preoperative muscle mass and quality on surgical outcomes in patients undergoing major hepatectomy for perihilar cholangiocarcinoma.

Asai Y, Yamaguchi J, Mizuno T, Onoe S, Watanabe N, Igami T, Uehara K, Yokoyama Y, Ebata T

Journal of hepato-biliary-pancreatic sciences   Vol. 30 ( 2 ) page： 202 - 211   2023.2

Antitumor Effects of Deep Ultraviolet Irradiation for Pancreatic Cancer.

Yamazaki K, Kokuryo T, Yamaguchi J, Sunagawa M, Ogura A, Watanabe N, Onoe S, Miyata K, Mizuno T, Uehara K, Igami T, Yokoyama Y, Ebata T, Nagino M

Anticancer research   Vol. 43 ( 2 ) page： 621 - 630   2023.2

Minimum radial margin in pelvic exenteration for locally advanced or recurrent rectal cancer.

Aiba T, Uehara K, Tsuyuki Y, Ogura A, Murata Y, Mizuno T, Yamaguchi J, Kokuryo T, Yokoyama Y, Ebata T

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology   Vol. 48 ( 12 ) page： 2502 - 2508   2022.12

Early volume loss of skeletal muscle after esophagectomy: a risk for late-onset postoperative pneumonia.

Nishimura K, Miyata K, Fukaya M, Yokoyama Y, Uehara K, Yamaguchi J, Mizuno T, Onoe S, Ogura A, Ebata T

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus   Vol. 35 ( 11 )   2022.11

Is a specific T classification needed for extrahepatic intraductal papillary neoplasm of the bile duct (IPNB) type 2 associated with invasive carcinoma?

Mitake Y, Onoe S, Igami T, Mizuno T, Yamaguchi J, Sunagawa M, Watanabe N, Kawakatsu S, Shimoyama Y, Ebata T

Journal of hepato-biliary-pancreatic sciences     2022.11

A proposal of drain removal criteria in hepatobiliary resection.

Watanabe N, Mizuno T, Yamaguchi J, Yokoyama Y, Igami T, Onoe S, Uehara K, Sunagawa M, Ebata T

Journal of hepato-biliary-pancreatic sciences   Vol. 29 ( 9 ) page： 974 - 982   2022.9

Trefoil factor 1 inhibits the development of esophageal adenocarcinoma from Barrett's epithelium.

Hasebe K, Yamazaki K, Yamaguchi J, Kokuryo T, Yokoyama Y, Miyata K, Fukaya M, Nagino M, Ebata T

Laboratory investigation; a journal of technical methods and pathology   Vol. 102 ( 8 ) page： 885 - 895   2022.8

Mild Prognostic Impact of Postoperative Complications on Long-term Survival of Perihilar Cholangiocarcinoma.

Kawakatsu S, Ebata T, Watanabe N, Onoe S, Yamaguchi J, Mizuno T, Igami T, Yokoyama Y, Matsuo K, Nagino M

Annals of surgery   Vol. 276 ( 1 ) page： 146 - 152   2022.7

Superiority of clinical American Joint Committee on Cancer T classification for perihilar cholangiocarcinoma.

Yamada M, Mizuno T, Yamaguchi J, Yokoyama Y, Igami T, Onoe S, Watanabe N, Uehara K, Matsuo K, Ebata T

Journal of hepato-biliary-pancreatic sciences   Vol. 29 ( 7 ) page： 768 - 777   2022.7

Results of a Phase II Study on the Use of Neoadjuvant Chemotherapy (FOLFIRINOX or GEM/nab-PTX) for Borderline-resectable Pancreatic Cancer (NUPAT-01).

Yamaguchi J, Yokoyama Y, Fujii T, Yamada S, Takami H, Kawashima H, Ohno E, Ishikawa T, Maeda O, Ogawa H, Kodera Y, Nagino M, Ebata T

Annals of surgery   Vol. 275 ( 6 ) page： 1043 - 1049   2022.6

Combined Vascular Resection for Locally Advanced Perihilar Cholangiocarcinoma.

Mizuno T, Ebata T, Yokoyama Y, Igami T, Yamaguchi J, Onoe S, Watanabe N, Kamei Y, Nagino M

Annals of surgery   Vol. 275 ( 2 ) page： 382 - 390   2022.2

A long-term survivor of advanced retroperitoneal dedifferentiated liposarcoma: a successful multimodal approach with extended resection and chemotherapy.

Nakahashi K, Yokoyama Y, Fukaya M, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Ebata T

Nagoya journal of medical science   Vol. 84 ( 1 ) page： 200 - 207   2022.2

Predicting Inchinkoto efficacy, in patients with obstructive jaundice associated with malignant tumors, through pharmacomicrobiomics.

Yamashita H, Nishiyama M, Ohbuchi K, Kanno H, Tsuchiya K, Yamaguchi J, Mizuno T, Ebata T, Nagino M, Yokoyama Y

Pharmacological research   Vol. 175   page： 105981   2022.1

Trefoil factor family 2 inhibits cholangiocarcinogenesis by regulating the PTEN pathway in mice.

Hasebe K, Yamaguchi J, Kokuryo T, Yokoyama Y, Ochiai Y, Nagino M, Ebata T

Carcinogenesis   Vol. 42 ( 12 ) page： 1496 - 1505   2021.12

[Ⅱ.Treatment for Recurrent Cholangiocarcinoma].

Watanabe N, Yokoyama Y, Igami T, Uehara K, Mizuno T, Yamaguchi J, Miyata K, Onoe S, Ogura A, Ebata T

Gan to kagaku ryoho. Cancer & chemotherapy   Vol. 48 ( 10 ) page： 1223 - 1226   2021.10

A clinicopathological reappraisal of intraductal papillary neoplasm of the bile duct (IPNB): a continuous spectrum with papillary cholangiocarcinoma in 181 curatively resected cases.

Onoe S, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Watanabe N, Otsuka S, Nakamura S, Shimoyama Y, Nagino M

HPB : the official journal of the International Hepato Pancreato Biliary Association   Vol. 23 ( 10 ) page： 1525 - 1532   2021.10

Adjuvant S-1 vs gemcitabine for node-positive perihilar cholangiocarcinoma: A propensity score-adjusted analysis.

Takahashi D, Mizuno T, Yokoyama Y, Igami T, Yamaguchi J, Onoe S, Watanabe N, Maeda O, Ando M, Ebata T

Journal of hepato-biliary-pancreatic sciences   Vol. 28 ( 9 ) page： 716 - 726   2021.9

A presurgical prognostic stratification based on nutritional assessment and carbohydrate antigen 19-9 in pancreatic carcinoma: An approach with nonanatomic biomarkers.

Onoe S, Yokoyama Y, Kokuryo T, Igami T, Mizuno T, Yamaguchi J, Watanabe N, Kawakatsu S, Ebata T

Surgery   Vol. 169 ( 6 ) page： 1463 - 1470   2021.6

Hepatopancreatoduodenectomy with simultaneous resection of the portal vein and hepatic artery for locally advanced cholangiocarcinoma: Short- and long-term outcomes of superextended surgery.

Nagino M, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N

Journal of hepato-biliary-pancreatic sciences   Vol. 28 ( 4 ) page： 376 - 386   2021.4

A Study on Radial Margin Status in Resected Perihilar Cholangiocarcinoma.

Shinohara K, Ebata T, Shimoyama Y, Mizuno T, Yokoyama Y, Yamaguchi J, Onoe S, Watanabe N, Nagino M

Annals of surgery   Vol. 273 ( 3 ) page： 572 - 578   2021.3

Application of fluorescent cholangiography during single-incision laparoscopic cholecystectomy in the cystohepatic duct without preoperative diagnosis.

Asai Y, Igami T, Ebata T, Yokoyama Y, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Nagino M

ANZ journal of surgery   Vol. 91 ( 3 ) page： 470 - 472   2021.3

Impact of Preoperative Occult-Bacterial Translocation on Surgical Site Infection in Patients Undergoing Pancreatoduodenectomy.

Suenaga M, Yokoyama Y, Fujii T, Yamada S, Yamaguchi J, Hayashi M, Asahara T, Nagino M, Kodera Y

Journal of the American College of Surgeons   Vol. 232 ( 3 ) page： 298 - 306   2021.3

Premalignant pancreatic cells seed stealth metastasis in distant organs in mice.

Yamaguchi J, Kokuryo T, Yokoyama Y, Ebata T, Ochiai Y, Nagino M

Oncogene   Vol. 40 ( 12 ) page： 2273 - 2284   2021.3

Impact of the preoperative body composition indexes on intraoperative blood loss in patients undergoing pancreatoduodenectomy.

Ishii K, Yokoyama Y, Ebata T, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Nagino M

Surgery today   Vol. 51 ( 1 ) page： 52 - 60   2021.1

Impact of Perioperative Steroid Administration in Patients Undergoing Major Hepatectomy with Extrahepatic Bile Duct Resection: A Randomized Controlled Trial.

Onoe S, Yokoyama Y, Ebata T, Igami T, Mizuno T, Yamaguchi J, Watanabe N, Suzuki S, Nishiwaki K, Ando M, Nagino M

Annals of surgical oncology   Vol. 28 ( 1 ) page： 121 - 130   2021.1

Impact of Qualitative and Quantitative Biliary Contamination Status on the Incidence of Postoperative Infection Complications in Patients Undergoing Pancreatoduodenectomy.

Suenaga M, Yokoyama Y, Fujii T, Yamada S, Yamaguchi J, Hayashi M, Asahara T, Nagino M, Kodera Y

Annals of surgical oncology   Vol. 28 ( 1 ) page： 560 - 569   2021.1

The influence of the preoperative thickness of the abdominal cavity on the gastrojejunal anatomic position and delayed gastric emptying after pancreatoduodenectomy.

Watanabe N, Yokoyama Y, Ebata T, Igami T, Mizuno T, Yamaguchi J, Onoe S, Nagino M

HPB : the official journal of the International Hepato Pancreato Biliary Association   Vol. 22 ( 12 ) page： 1695 - 1702   2020.12

Study of the Portal Branches Arising from the Cranial Part of the Umbilical Portion of the Left Portal Vein: Implications for Anatomic Right Hepatic Trisectionectomy.

Minami T, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Nagino M

World journal of surgery   Vol. 44 ( 12 ) page： 4231 - 4235   2020.12

How long should follow-up be continued after R0 resection of perihilar cholangiocarcinoma?

Nakahashi K, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Nagino M

Surgery   Vol. 168 ( 4 ) page： 617 - 624   2020.10

Tumor marker recovery rather than major pathological response is a preferable prognostic factor in patients with pancreatic ductal adenocarcinoma with preoperative therapy.

Yamada S, Yokoyama Y, Sonohara F, Yamaguchi J, Takami H, Hayashi M, Onoe S, Fujii T, Nagino M, Kodera Y

Journal of hepato-biliary-pancreatic sciences   Vol. 27 ( 8 ) page： 487 - 495   2020.8

Trefoil Factor Family 1 Inhibits the Development of Hepatocellular Carcinoma by Regulating β-Catenin Activation.

Ochiai Y, Yamaguchi J, Kokuryo T, Yokoyama Y, Ebata T, Nagino M

Hepatology (Baltimore, Md.)   Vol. 72 ( 2 ) page： 503 - 517   2020.8

Postoperative infectious complications caused by multidrug-resistant pathogens in patients undergoing major hepatectomy with extrahepatic bile duct resection.

Sugawara G, Yokoyama Y, Ebata T, Igami T, Yamaguchi J, Mizuno T, Onoe S, Watanabe N, Nagino M

Surgery   Vol. 167 ( 6 ) page： 950 - 956   2020.6

Study on the Segmentation of the Right Posterior Sector of the Liver.

Minami T, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Nagino M

World journal of surgery   Vol. 44 ( 3 ) page： 896 - 901   2020.3

Predictive performance of Blumgart T staging for perihilar cholangiocarcinoma in a Japanese center.

Ebata T, Mizuno T, Yokoyama Y, Igami T, Yamaguchi J, Onoe S, Watanabe N, Nagino M

Journal of hepato-biliary-pancreatic sciences   Vol. 27 ( 3 ) page： 132 - 140   2020.3

Postoperative Pancreatic Fistula in Surgery for Perihilar Cholangiocarcinoma.

Watanabe N, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Nagino M

World journal of surgery   Vol. 43 ( 12 ) page： 3094 - 3100   2019.12

A case of small in situ perihilar cholangiocarcinoma incidentally accompanied by benign bile duct stricture after open cholecystectomy.

Maeda T, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Nagino M

Surgical case reports   Vol. 5 ( 1 ) page： 177   2019.11

Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis.

Mizutani Y, Kobayashi H, Iida T, Asai N, Masamune A, Hara A, Esaki N, Ushida K, Mii S, Shiraki Y, Ando K, Weng L, Ishihara S, Ponik SM, Conklin MW, Haga H, Nagasaka A, Miyata T, Matsuyama M, Kobayashi T, Fujii T, Yamada S, Yamaguchi J, Wang T, Woods SL, Worthley D, Shimamura T, Fujishiro M, Hirooka Y, Enomoto A, Takahashi M

Cancer research   Vol. 79 ( 20 ) page： 5367 - 5381   2019.10

Discrepancy between volume and functional recovery in early phase liver regeneration following extended hepatectomy with extrahepatic bile duct resection.

Maeda T, Yokoyama Y, Ebata T, Igami T, Mizuno T, Yamaguchi J, Onoe S, Ando M, Nagino M

Hepatology research : the official journal of the Japan Society of Hepatology   Vol. 49 ( 10 ) page： 1227 - 1235   2019.10

Benign hilar bile duct strictures resected as perihilar cholangiocarcinoma.

Otsuka S, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Shimoyama Y, Nagino M

The British journal of surgery   Vol. 106 ( 11 ) page： 1504 - 1511   2019.10

Occult synchronous liver metastasis from perihilar cholangiocarcinoma.

Ohiwa T, Ebata T, Mizuno T, Yokoyama Y, Yamaguchi J, Onoe S, Watanabe N, Nagino M

Surgery   Vol. 166 ( 3 ) page： 290 - 296   2019.9

Cholangiographic Tumor Classification for Simple Patient Selection Prior to Hepatopancreatoduodenectomy for Cholangiocarcinoma.

Toyoda Y, Ebata T, Mizuno T, Yokoyama Y, Igami T, Yamaguchi J, Onoe S, Watanabe N, Nagino M

Annals of surgical oncology   Vol. 26 ( 9 ) page： 2971 - 2979   2019.9

Preoperative course of patients undergoing endoscopic nasobiliary drainage during the management of resectable perihilar cholangiocarcinoma.

Maeda T, Ebata T, Yokoyama Y, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Kawashima H, Nagino M

Journal of hepato-biliary-pancreatic sciences   Vol. 26 ( 8 ) page： 341 - 347   2019.8

Left trisectionectomy combined with resection of the right hepatic vein and inferior vena cava after right hepatic vein embolization for advanced intrahepatic cholangiocarcinoma.

Suzuki T, Ebata T, Yokoyama Y, Mizuno T, Igami T, Yamaguchi J, Onoe S, Watanabe N, Nagino M

Surgical case reports   Vol. 5 ( 1 ) page： 98   2019.6

Is constant negative pressure for external drainage of the main pancreatic duct useful in preventing pancreatic fistula following pancreatoduodenectomy?

Sunagawa M, Yokoyama Y, Yamaguchi J, Ebata T, Sugawara G, Igami T, Mizuno T, Nagino M

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]   Vol. 19 ( 4 ) page： 602 - 607   2019.6

NEK2 Is an Effective Target for Cancer Therapy With Potential to Induce Regression of Multiple Human Malignancies.

Kokuryo T, Yokoyama Y, Yamaguchi J, Tsunoda N, Ebata T, Nagino M

Anticancer research   Vol. 39 ( 5 ) page： 2251 - 2258   2019.5

Phase II study of chemoradiotherapy combined with gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic ductal adenocarcinoma (NUPAT 05 Trial): study protocol for a single arm phase II study.

Takano N, Yamada S, Hirakawa A, Yokoyama Y, Kawashima H, Maeda O, Okada T, Ohno E, Yamaguchi J, Ishikawa T, Sonohara F, Suenaga M, Takami H, Hayashi M, Niwa Y, Hirooka Y, Ito Y, Naganawa S, Ando Y, Nagino M, Goto H, Fujii T, Kodera Y

Nagoya journal of medical science   Vol. 81 ( 2 ) page： 233 - 239   2019.5

Pleural dissemination of cholangiocarcinoma caused by percutaneous transhepatic biliary drainage during the management of resectable cholangiocarcinoma.

Yamashita H, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Ando M, Nagino M

Surgery   Vol. 165 ( 5 ) page： 912 - 917   2019.5

Major hepatectomy with or without pancreatoduodenectomy for advanced gallbladder cancer.

Mizuno T, Ebata T, Yokoyama Y, Igami T, Yamaguchi J, Onoe S, Watanabe N, Ando M, Nagino M

The British journal of surgery   Vol. 106 ( 5 ) page： 626 - 635   2019.4

A case of human pancreatic eurytremiasis.

Ogawa H, Takehara Y, Naganawa S, Yamaguchi J, Nakaguro M

Abdominal radiology (New York)   Vol. 44 ( 4 ) page： 1213 - 1216   2019.4

Pharmacokinetics of Nek2 siRNA in Peritoneal Dissemination of Pancreatic Cancer

Kokuryo T., Yamaguchi J., Yokoyama Y., Nagino M.

PANCREAS   Vol. 48 ( 10 ) page： 1465 - 1465   2019

Trefoil Factor Family 1 (TFF1) Inhibits Epithelial-mesenchymal Transition and Enhances the Chemosensitivity of Pancreatic Ductal Adenocarcinoma (PDAC)

Yamaguchi J., Kokuryo T., Yokoyama Y., Ebata T., Nagino M.

PANCREAS   Vol. 48 ( 10 ) page： 1551 - 1552   2019

Anti-tumor Effects of Deep Ultraviolet Irradiation for Pancreas Cancer

Yamazaki K., Kokuryo T., Yamaguchi J., Yokoyama Y., Nagino M.

PANCREAS   Vol. 48 ( 10 ) page： 1553 - 1553   2019

Comparison between autologous and homologous blood transfusions in liver resection for biliary tract cancer: a propensity score matching analysis.

Onoe S, Yokoyama Y, Ebata T, Igami T, Mizuno T, Yamaguchi J, Watanabe N, Nagino M

Journal of hepato-biliary-pancreatic sciences   Vol. 25 ( 12 ) page： 550 - 559   2018.12

Loss of trefoil factor 1 inhibits biliary regeneration but accelerates the hepatic differentiation of progenitor cells in mice.

Hayashi Y, Yamaguchi J, Kokuryo T, Ebata T, Yokoyama Y, Nagino M

Biochemical and biophysical research communications   Vol. 506 ( 1 ) page： 12 - 19   2018.11

Surgery for perihilar cholangiocarcinoma from a viewpoint of age: Is it beneficial to octogenarians in an aging society?

Akashi K, Ebata T, Mizuno T, Yokoyama Y, Igami T, Yamaguchi J, Onoe S, Nagino M

Surgery   Vol. 164 ( 5 ) page： 1023 - 1029   2018.11

Application of three-dimensional print in minor hepatectomy following liver partition between anterior and posterior sectors.

Igami T, Nakamura Y, Oda M, Tanaka H, Nojiri M, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Yamaguchi J, Mori K, Nagino M

ANZ journal of surgery   Vol. 88 ( 9 ) page： 882 - 885   2018.9

Ethanol ablation for refractory bile leakage after complex hepatectomy.

Ito A, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Nagino M

The British journal of surgery   Vol. 105 ( 8 ) page： 1036 - 1043   2018.7

Application of fluorescent cholangiography during single-incision laparoscopic cholecystectomy for cholecystitis with a right-sided round ligament: Preliminary experience.

Nojiri M, Igami T, Toyoda Y, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

Journal of minimal access surgery   Vol. 14 ( 3 ) page： 244 - 246   2018.7

Preoperative biliary colonization/infection caused by multidrug-resistant (MDR) pathogens in patients undergoing major hepatectomy with extrahepatic bile duct resection.

Sugawara G, Yokoyama Y, Ebata T, Igami T, Yamaguchi J, Mizuno T, Yagi T, Nagino M

Surgery   Vol. 163 ( 5 ) page： 1106 - 1113   2018.5

Phase I study of chemoradiotherapy using gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic cancer.

Yamada S, Fujii T, Yokoyama Y, Kawashima H, Maeda O, Suzuki K, Okada T, Ono E, Yamaguchi J, Takano N, Takami H, Hayashi M, Niwa Y, Hirooka Y, Ito Y, Naganawa S, Ando Y, Nagino M, Goto H, Kodera Y

Cancer chemotherapy and pharmacology   Vol. 81 ( 5 ) page： 815 - 821   2018.5

Impact of the gastrojejunal anatomic position as the mechanism of delayed gastric emptying after pancreatoduodenectomy.

Nojiri M, Yokoyama Y, Maeda T, Ebata T, Igami T, Sugawara G, Yamaguchi J, Nagino M

Surgery   Vol. 163 ( 5 ) page： 1063 - 1070   2018.5

Recurrence after curative-intent resection of perihilar cholangiocarcinoma: analysis of a large cohort with a close postoperative follow-up approach.

Komaya K, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

Surgery   Vol. 163 ( 4 ) page： 732 - 738   2018.4

Pre-exposure to Fluorouracil Increased Trifluridine Incorporation and Enhanced its Anti-tumor Effect for Colorectal Cancer.

Baba T, Kokuryo T, Yamaguchi J, Yokoyama Y, Uehara K, Ebata T, Nagino M

Anticancer research   Vol. 38 ( 3 ) page： 1427 - 1434   2018.3

Inhibition of Toll-like receptor 4 ameliorates experimental postischemic injury in the cholestatic liver through inhibition of high-mobility group box protein b1 (HMGB1) signaling.

Yokoi T, Yokoyama Y, Kokuryo T, Yamaguchi J, Nagino M

Surgery   Vol. 163 ( 2 ) page： 270 - 276   2018.2

Does the intestinal microenvironment have an impact on the choleretic effect of inchinkoto, a hepatoprotective herbal medicine?

Uji M, Yokoyama Y, Asahara T, Ebata T, Igami T, Mizuno T, Yamaguchi J, Nagino M

Hepatology research : the official journal of the Japan Society of Hepatology   Vol. 48 ( 3 ) page： E303 - E310   2018.2

Cells of Origin of Pancreatic Neoplasms Reviewed

Yamaguchi J, Yokoyama Y, Kokuryo T, Ebata T, Nagino M.

Surgery Today   Vol. 48 ( 1 ) page： 9-17   2018.1

Cells of origin of pancreatic neoplasms.

Yamaguchi J, Yokoyama Y, Kokuryo T, Ebata T, Nagino M

Surgery today   Vol. 48 ( 1 ) page： 9 - 17   2018.1

Single-Incision Laparoscopic Splenectomy for an Unruptured Aneurysm of the Splenic Artery.

Toyoda Y, Igami T, Ochiai Y, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

Medical principles and practice : international journal of the Kuwait University, Health Science Centre   Vol. 27 ( 1 ) page： 95 - 98   2018

Successful local treatment for repeated hepatic recurrences of cholangiolocellular carcinoma: a report on a long-term survivor.

Shinohara K, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Shimoyama Y, Shiina S, Tateishi R, Arano T, Nagino M

Surgical case reports   Vol. 3 ( 1 ) page： 120   2017.12

Occult mucin-producing cholangiocarcinoma in situ: a rare clinical case with difficult tumour staging.

Kiriyama M, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

Surgical case reports   Vol. 3 ( 1 ) page： 6   2017.12

Long-term survival after multidisciplinary therapy for residual gallbladder cancer with peritoneal dissemination: a case report.

Kuga D, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

Surgical case reports   Vol. 3 ( 1 ) page： 76   2017.12

Real-world experience with FOLFIRINOX and gemcitabine plus nab-paclitaxel in the treatment of pancreatic cancer in Japan

Maeda O., Yokoyama Y., Yamaguchi J., Ota A., Matsuoka A., Morita S., Inoue M., Mizutani T., Shimokata T., Urakawa H., Mitsuma A., Nagino M., Ando Y.

ANNALS OF ONCOLOGY   Vol. 28   page： 69 - 69   2017.11

Clinical influence of preoperative factor XIII activity in patients undergoing pancreatoduodenectomy.

Watanabe N, Yokoyama Y, Ebata T, Sugawara G, Igami T, Mizuno T, Yamaguchi J, Nagino M

HPB : the official journal of the International Hepato Pancreato Biliary Association   Vol. 19 ( 11 ) page： 972 - 977   2017.11

The novel tumor suppressor Trefoil Factor Family 1 (TFF1) inhibits the development of hepatocellular carcinoma in mice

Yamaguchi Junpei, Yokoyama Yukihiro, Kokuryo Toshio, Ebata Tomoki, Nagino Masato

HEPATOLOGY   Vol. 66   page： 981A-982A   2017.10

Loss of trefoil factor 1 inhibits biliary regeneration but accelerates the differentiation of hepatic progenitors into hepatocytes in mice

Hayashi Yuki, Yamaguchi Junpei, Kokuryo Toshio, Ebata Tomoki, Yokoyama Yukihiro, Nagino Masato

HEPATOLOGY   Vol. 66   page： 378A - 379A   2017.10

Inhibition of Toll-Like Receptor 4 Ameliorates Experimental Post-Ischemic Injury in the Cholestatic Liver through Inhibition of High-Mobility Group Box Protein B1 (HMGB1) Signaling

Yokoi Tsuyoshi, Yokoyama Yukihiro, Kokuryo Toshio, Yamaguchi Junpei, Nagino Masato

HEPATOLOGY   Vol. 66   page： 153A - 153A   2017.10

Trefoil factor family 1 expression in the invasion front is a poor prognostic factor associated with lymph node metastasis in pancreatic cancer.

Sunagawa M, Yamaguchi J, Kokuryo T, Ebata T, Yokoyama Y, Sugawara G, Nagino M

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]   Vol. 17 ( 5 ) page： 782 - 787   2017.9

Study on the segmentation of the right anterior sector of the liver.

Kobayashi T, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

Surgery   Vol. 161 ( 6 ) page： 1536 - 1542   2017.6

Pulmonary Metastasis After Resection of Cholangiocarcinoma: Incidence, Resectability, and Survival.

Yamada M, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

World journal of surgery   Vol. 41 ( 6 ) page： 1550 - 1557   2017.6

Novel therapy for pancreatic fistula using adipose-derived stem cell sheets treated with mannose.

Kaneko H, Kokuryo T, Yokoyama Y, Yamaguchi J, Yamamoto T, Shibata R, Gotoh M, Murohara T, Ito A, Nagino M

Surgery   Vol. 161 ( 6 ) page： 1561 - 1569   2017.6

The development of an automatically produced cholangiography procedure using the reconstruction of portal-phase multidetector-row computed tomography images: preliminary experience.

Hirose T, Igami T, Koga K, Hayashi Y, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Yamaguchi J, Mori K, Nagino M

Surgery today   Vol. 47 ( 3 ) page： 365 - 374   2017.3

Verification of the oncologic inferiority of percutaneous biliary drainage to endoscopic drainage: A propensity score matching analysis of resectable perihilar cholangiocarcinoma.

Komaya K, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

Surgery   Vol. 161 ( 2 ) page： 394 - 404   2017.2

Surgery-Related Muscle Loss and Its Association with Postoperative Complications After Major Hepatectomy with Extrahepatic Bile Duct Resection.

Otsuji H, Yokoyama Y, Ebata T, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

World journal of surgery   Vol. 41 ( 2 ) page： 498 - 507   2017.2

The Anticancer Effects of Novel α-Bisabolol Derivatives Against Pancreatic Cancer.

Murata Y, Kokuryo T, Yokoyama Y, Yamaguchi J, Miwa T, Shibuya M, Yamamoto Y, Nagino M

Anticancer research   Vol. 37 ( 2 ) page： 589 - 598   2017.2

Adjuvant gemcitabine monotherapy for resectable perihilar cholangiocarcinoma with lymph node involvement: a propensity score matching analysis.

Mizuno T, Ebata T, Yokoyama Y, Igami T, Sugawara G, Yamaguchi J, Nagino M

Surgery today   Vol. 47 ( 2 ) page： 182 - 192   2017.2

Anatomic features of independent right posterior portal vein variants: Implications for left hepatic trisectionectomy.

Watanabe N, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

Surgery   Vol. 161 ( 2 ) page： 347 - 354   2017.2

Different Clinical Characteristics Between Distal Cholangiocarcinoma and Pancreatic Head Carcinoma With Biliary Obstruction

Yokoyama Yukihiro, Ebata Tomoki, Igami Tsuyoshi, Sugawara Gen, Mizuno Takashi, Yamaguchi Junpei, Nagino Masato

PANCREAS   Vol. 46 ( 10 ) page： 1322 - 1326   2017

The Benefit of Extended Radical Surgery for Incidental Gallbladder Carcinoma Reviewed

Junpei Yamaguchi, Yuji Kaneoka, Atsuyuki Maeda, Yuichi Takayama, Shunsuke Onoe and Masatoshi Isogai

Surgery Today   Vol. 46   page： 453-459   2016

Positive surgical margins in surgically resected unifocal and multifocal IPMN Reviewed

Junpei Yamaguchi, Yuji Kaneoka, Atsuyuki Maeda, Yuichi Takayama, Shunsuke Onoe and Masatoshi Isogai

International Journal of Surgery   Vol. 28   page： 51-55   2016

Pancreatic duct gland (PDGs) are a progenitor compartment responsible for pancreatic ductal epithelial repair Reviewed

Junpei Yamaguchi, Andrew S. Liss, Alexandra Sontheimer, Mari Mino-Kenudson, Carlos Fernandez-del Castillo, Andrew L. Warshaw, Sarah P. Thayer

Stem Cell Research   Vol. 15   page： 190-202   2015

The role of histone deacetylase (HDAC) and EZH2 in oncogenesis: epigenetic silencing of tumor supressors Invited Reviewed

Junpei Yamaguchi, Motoko Sasaki and Yasuni Nakanuma

Tumor Suppressors     page： 149-160   2011

Papillary hyperplasia of the gallbladder in pancreaticobiliary maljunction represents a senescencerelated lesion induced by lysolecithin Reviewed

Junpei Yamaguchi, Motoko Sasaki, Kenichi Harada, Yoh Zen, Yasunori Sato, Hiroko Ikeda, Keita Itatsu, Yukihiro Yokoyama, Hisami Ando, Tetsuo Ohta, Akio Kubota, Koichi Shimizu, Yuji Nimura, Masato Nagino and Yasuni Nakanuma

laboratory investigation   Vol. 89   page： 1018-1031   2009

Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma Reviewed

Junpei Yamaguchi, Motoko Sasaki, Yasunori Sato, Keita Itatsu, Kenichi Harada, Yoh Zen, Hiroko Ikeda, Yuji Nimura, Masato Nagino and Yasuni Nakanuma

Cancer Science   Vol. 101 ( 2 ) page： 355-362   2009

化学放射線療法による寛解導入後に胃癌が発見された2症例 Invited Reviewed

山口淳平、片井均、佐野武、深川剛生、阪眞、井上昌也、笹子三津留、谷口浩和

日本消化器外科学会雑誌   Vol. 41 ( 9 ) page： 1682-1685   2008

Spontaneous regression of inflammatory pseudotumor of the liver: three case reports Reviewed

Junpei Yamaguchi, Yoshihiro Sakamoto, Tsuyoshi Sano, Kazuaki Shimada, Tomoo Kosuge

surgery today   Vol. 37 ( 6 ) page： 525-529   2007

高アルドステロン血症と耐糖能異常を合併した若年者肝細胞癌の一例 Invited Reviewed

山口淳平、佐野力、島田和明、阪本良弘、奈良聡、小菅智男

日本消化器外科学会雑誌   Vol. 40 ( 5 ) page： 611-616   2007

A case of mucinous carcinoma of the breast that demonstrated a good pathological response to neoadjuvant chemotherapy despite a poor clinacal response Reviewed

Junpei Yamaguchi, Sadako Akashi-Tanaka, Takayoshi Fukutomi, Takayuki Kinoshita, Eriko Iwamoto, Miyuki Takasugi

Breast Cancer   Vol. 13 ( 1 ) page： 100-103   2006

A case of mucinous cystic tumor of the pancreatic tail Reviewed

Junpei Yamaguchi, Yoshihiro Sakamoto

Japanese Journal of Clinical Oncology   Vol. 36 ( 1 ) page： 65   2006

Poorly differentiated hepatocellular carcinoma with unusual tubular structures Reviewed

Junpei Yamaguchi, Hidenori Ojima, Nobuyoshi Hiraoka, Tadashi Hasegawa

Journal of Clinical Pathology   Vol. 58   page： 1342   2005

TFF1による膵発癌抑制機構の検討

山口淳平、江畑智希、横山幸浩、國料俊男、伊神剛、水野隆史、尾上俊介、渡辺伸元

日本外科学会定期学術集会  2019.4 

Trefoil Factor 1 inhibits epithelial-mesenchymal transition (EMT) of pancreatic intraepithelial neoplasm. International conference

Junpei Yamaguchi, Yukihiro Yokoyama, Toshio Kokuryo and Masato Nagino

AACR Pancreatic cancer: advances in science and clinical care  2018.9 

The novel tumor suppressor Trefoil Factor Family 1 (TFF1) inhibits the development of hepatocellular carcinoma in mice International conference

Junpei Yamaguchi, Yukihiro Yokoyama, Toshio Kokuryo and Masato Nagino

AASLD the Liver Meeting 2017  2017.10 

遺伝子改変マウスを用いたTFF1欠損による膵浸潤癌発生に関する検討

山口淳平、江畑智希、横山幸浩、國料俊男、梛野正人

第48回日本膵臓学会大会  2017.7 

Preserved expression of TFF1 in invasive front is a poor prognostic factor in PDAC International conference

Junpei Yamaguchi, Masaki Sunagawa, Yukihiro yokoyama, Toshio Kokuryo, Tomoki Ebata, Masato Nagino

Joint Congress of The 6th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association &　The 29th Meeting of Japanese Society of Hepato-Biliary-Pancreatic Surgery  2017.6 

TFF1 (Trefoil Factor Family 1) act as tumor suppressor to inhibit invasive transformation of PanIN into PDAC in vivo International conference

Junpei Yamaguchi, Yukihiro Yokoyama, Toshio Kokuryo and Masato Nagino

47th APA annual meeting 

The tumor suppressive role of TFF (Trefoil Factor Family) in pancreatic carcinogenesis International conference

Junpei Yamaguchi, Yukihiro Yokoyama, Toshio Kokuryo and Masato Nagino

20th meeting of IAP, 6th meeting of AOPA 

TFF (Trefoil Factor Family) is a novel tumor suppressor and can be the therapeutic target for pancreatic cancer International conference

Junpei Yamaguchi, Yukihiro Yokoyama, Toshio Kokuryo and Masato Nagino

An AACR Special Conference on Pancreatic Cancer 

TFF1 (Trefoil Factor Family 1) act as tumor suppressor to prevent invasive transformation of pancreatic cancer International conference

膵癌に対するTrefoil Factor Family 2 (TFF2)の抗腫瘍効果の検討 International conference

山口淳平、S.P. Thayer, A.L. Warshaw、江畑智希、横山幸弘、國料俊男、伊神剛、菅原元、水野隆司、梛野正人

日本消化器外科学会総会 

膵癌抑制因子としてのTrefoil Factor Family 1 (TFF1)の役割の検討 International conference

山口淳平、江畑智希、横山幸弘、國料俊男、伊神剛、菅原元、水野隆司、梛野正人

日本肝胆膵外科学会学術集会 

Trefoil Family Factor 2 (TFF2)抑制による膵IPMN発生マウスモデルの検討 International conference

山口淳平、S.P. Thayer, A.L. Warshaw、江畑智希、横山幸弘、國料俊男、梛野正人

日本外科学会定期学術集会 

Trefoil Factor Family 1 (TFF1) Inhibit the Invasion of Tumor Cells of the Pancreas International conference

Junpei Yamaguchi, Toshio Kokuryo, Yukihiro Yokoyama and Masato Nagino

Experimantal Biology 2015 

当院におけるIPMN切除例55例の治療成績の検討

山口淳平、磯谷正敏、原田徹、金岡祐次、亀井桂太郎、前田敦行、高山祐一、川勝章司、大塚新平、森治樹、米川佳彦、掘米香世子、渡辺夕樹、千馬耕亮

日本肝胆膵外科学会 

当院におけるIncidental Gallbladder Carcinomaに対する追加切除とその予後の検討

山口淳平、磯谷正敏、原田徹、金岡祐次、亀井桂太郎、前田敦行、高山祐一、川勝章司、大塚新平、森治樹、米川佳彦、掘米香世子、渡辺夕樹、千馬耕亮

日本臨床外科学会総会 

Loss of TFF2 in Pancreatic Duct Glands (PDG) results in the formation of IPMN suggesting TFF2 may function as tumor suppressor. International conference

Pancreatic Duct Glands (PDG), a Progenitor Stem Cell Niche Responsible for Pancreatic Epithelial Renewal and Repair in Response to Inflammatory Injury International conference

Pancreatic Duct Glands (PDG) Are the Origin of Gastric-Type IPMN International conference

Pancreatic Duct Glands (PDG), a Progenitor Stem Cell Niche Responsible for Pancreatic Epithelial Renewal International conference

Pancreati Duct Glands (PDG) Are the Origin of Gastric-type IPMN International conference

膵胆管合流異常症胆嚢における前癌病変と細胞老化機構の関与

山口淳平、佐々木素子、原田憲一、佐藤保則、池田博子、梛野正人、中沼安二

日本外科学会定期学術集会 

ヒストン脱アセチル化酵素阻害剤(SAHA)およびEZH2抑制による胆嚢癌増殖抑制効果

山口淳平、佐々木素子、原田憲一、佐藤保則、池田博子、梛野正人、中沼安二

日本胆道学会学術集会 

胆嚢前癌病変における細胞老化機構の関与

山口淳平、佐々木素子、原田憲一、佐藤保則、池田博子、板津慶太、梛野正人、中沼安二

日本胆道学会学術集会 

胆嚢前癌病変における細胞老化の関与

山口淳平、佐々木素子、原田憲一、佐藤保則、池田博子、中沼安二

日本病理学会総会 

高アルドステロン血症と耐糖能異常を合併した若年者肝細胞癌の一例

山口淳平、佐野力、島田和明、阪本良弘、奈良聡、小菅智男

日本消化器外科学会定期学術総会 

Novel diagnostic methods for invisible pancreas cancer

Grant number：19K09168  2019.4 - 2022.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

WATANABE Nobuyuki

The role of Trefoil Factors in hepato-carcinogenesis

Grant number：19K09141  2019.4 - 2022.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Ebata Tomoki

Novel therapy based on engraftment, asymmetric division and Self-organization of circulating tumor cells

Grant number：19K09142  2019.4 - 2021.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Novel nucleic acid medicine for the fusion genes in cholangiocarcinoma

Grant number：18H02879  2018.4 - 2022.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

Nagino Masato

The mechanisms of cancer development from Barrett esophagus regarding Trefoil Factors.

Grant number：18K08699  2018.4 - 2021.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Fukaya Masahide

Novel therapy for cancer using deep ultraviolet

Grant number：18K08673  2018.4 - 2021.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Miyata Kazushi

Development of real-time navigation system for hepatectomy

Grant number：18K08644  2018.4 - 2021.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

IGAMI TSUYOSHI

The role of TFF1 to inhibit the development of pancreatic cancer

Grant number：17K10695  2017.4 - 2020.3

Yamaguchi Junpei

術後肝障害に対するTLR4を標的にした予防治療法の開発

Grant number：17K10667  2017.4 - 2018.3

菅原 元

Novel strategies to target the premetastatic niche for cancer metastasis

Grant number：16K10568  2016.4 - 2019.3

MIZUNO TAKASHI

Mechanism of a new cancer treatment targeting TLR7

Grant number：16K10531  2016.4 - 2019.3

UEHARA KEISUKE

Analysis of the inhibitory effect of cysteine on liver damage

Grant number：16K10567  2016.4 - 2019.3

YOKOYAMA YUKIHIRO

Mechanism of action of a bisabolol derivative and its clinical application

Grant number：16K10591  2016.4 - 2019.3

KOKURYO TOSHIO

Novel strategies for cancer stem cells

Grant number：16K10454  2016.4 - 2019.3

TSUNODA NOBUYUKI

Novel strategies targeting RAGE for postoperative infectious complications

Grant number：15K10092  2015.4 - 2018.3

FUKAYA MASAHIDE

膵癌に対する腫瘍抑制因子としてのTFF2の検討

2014.4 - 2016.3

科学研究費補助金  研究活動スタート支援