Updated on 2022/03/30

写真a

 
SHIROTA Chiyoe
 
Organization
Nagoya University Hospital Pediatric Surgery Lecturer
Graduate School
Graduate School of Medicine
Title
Lecturer
External link

Degree 1

  1. 博士(医学) ( 2016.11   名古屋大学 ) 

Research Interests 4

  1. minimum invasive surgery

  2. telemedicine

  3. off the job training

  4. pediatric surgery

Research Areas 1

  1. Life Science / General surgery and pediatric surgery

Current Research Project and SDGs 1

  1. remote medical platforms

Professional Memberships 6

  1. 日本小児外科学会   評議員

  2. 日本超音波学会

  3. 小児救急医学会

  4. 日本小児血液・がん学会

  5. 周産期新生児学会

  6. 日本内視鏡外科学会

▼display all

 

Papers 65

  1. Long-term outcomes after revision of Kasai portoenterostomy for biliary atresia. Reviewed

    Shirota C, Uchida H, Ono Y, Murase N, Tainaka T, Yokota K, Oshima K, Shirotsuki R, Hinoki A, Ando H

    Journal of hepato-biliary-pancreatic sciences   Vol. 23 ( 11 ) page: 715-720   2016.11

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jhbp.395

    PubMed

  2. Laparoscopic Kasai portoenterostomy is advantageous over open Kasai portoenterostomy in subsequent liver transplantation Reviewed

    Shirota Chiyoe, Murase Naruhiko, Tanaka Yujiro, Ogura Yasuhiro, Nakatochi Masahiro, Kamei Hideya, Kurata Nobuhiko, Hinoki Akinari, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Oshima Kazuo, Uchida Hiroo

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   Vol. 34 ( 8 ) page: 3375 - 3381   2020.8

     More details

    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Surgical Endoscopy  

    Background: Native liver survival after laparoscopic Kasai portoenterostomy (Lap-PE) for biliary atresia (BA) is controversial. We examined whether a jaundice-free native liver survival rate is comparable between conventional Kasai portoenterostomy (Open-PE) and Lap-PE. Then, the impact of the two types of PE on subsequent living-donor liver transplantation (LTx) was addressed in this study. Methods: The jaundice-free rate in 1- and 2-year-old patients who underwent Open-PE and Lap-PE from January 2006 to December 2017 was investigated. Additionally, perioperative data (duration from the start of surgery to the completion of hepatectomy and others) of patients aged 2 years or younger who underwent LTx after either Open-PE or Lap-PE from 2006 to 2017 were evaluated. Results: Thirty-one (67%) out of 46 Open-PE patients and 23 (77%) out of 30 Lap-PE patients showed native liver survival with jaundice-free status at 1 year of age (p = 0.384); 29 (63%) out of 46 Open-PE patients and 19 (70%) out of 27 Lap-PE patients showed native liver survival with jaundice-free status at 2 years of age (p = 0.524); there were no significant differences. Additionally, there were 37 LTx cases after PE within 2 years of birth, including 29 Open-PE and 8 Lap-PE cases. The patients in the Lap-PE group had fewer adhesions and significantly shorter durations of surgery up to the completion of the recipient’s hepatectomy and durations of post-LTx hospital stay compared to the Open-PE group. There were no differences in blood loss or duration of stay in intensive care unit between the Lap-PE and Open-PE groups. Conclusions: Jaundice-free native liver survival rate has been comparable between Open-PE and Lap-PE. Lap-PE resulted in fewer adhesions, contributing to better outcomes of subsequent LTx compared to Open-PE.

    DOI: 10.1007/s00464-019-07108-y

    Web of Science

    Scopus

    PubMed

  3. Therapeutic strategy for thoracoscopic repair of esophageal atresia and its outcome Reviewed

    Shirota Chiyoe, Tanaka Yujiro, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Oshima Kazuo, Tanaka Tomoko, Tani Yukiko, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 35 ( 10 ) page: 1071 - 1076   2019.10

     More details

    Authorship:Lead author   Language:English   Publisher:Pediatric Surgery International  

    Purpose: Thoracoscopic repair can be safely performed in most types of congenital esophageal atresia (EA), including in patients with long gap EA or very low birth weight. Accordingly, we performed single- or multistage thoracoscopic repair for various EA types. We aimed to report our therapeutic strategy for thoracoscopic radical surgery for treating EA and its outcome. Methods: Outcomes of radical surgeries for treating congenital EA at our institute from 2013 to 2018 were retrospectively evaluated. Results: Thirty-eight radical surgeries were evaluated: 3 Gross type-A, 1 type-B, 30 type-C, 1 type-D, and 3 type-E. The cervical approach was performed in 5 cases and thoracoscopic esophageal anastomosis in 33, including 26 single-stage (all type-C) and 7 multistage surgeries (3 type-A, 3 type-C, and 1 type-D). There were no cases of thoracotomies or intraoperative thoracoscopic surgery complications. Three cases of minor leakage were conservatively resolved. Three postoperative chylothorax surgeries (9%) and seven balloon dilatations (21%) for anastomotic stenosis were performed. Conclusion: Thoracoscopic radical surgery for treating EA, including single- and multistage procedures, can be performed, except in type-E cases or when the end of the proximal esophagus is located higher than the clavicle.

    DOI: 10.1007/s00383-019-04541-x

    Web of Science

    Scopus

    PubMed

  4. Single-incision laparoscopic percutaneous extraperitoneal closure (SILPEC) for inguinal hernia with prolapsed ovary Reviewed

    Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Amano Hizuru, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Nakagawa Yoichi, Hinoki Akinari, Uchida Hiroo

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES     2021.10

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Surgical Endoscopy  

    Background: Most studies reporting the outcomes of laparoscopic ovarian prolapsed hernia operations with large sample sizes are based on intracorporeal closure, while studies on extraperitoneal closure have limited sample sizes. We proactively used the single-incision laparoscopic percutaneous extraperitoneal closure (SILPEC) technique and obtained favorable outcomes, which we report in this paper. Methods: We retrospectively reviewed patients who had undergone laparoscopic surgery for inguinal hernia at our institution. They were retrospectively classified into two groups based on the pre- or intraoperative diagnosis of hernia with a prolapsed ovary, namely the prolapse group and the non-prolapse group, respectively. The data were statistically analyzed and p < 0.05 was considered statistically significant. Results: A total of 771 subjects underwent SILPEC during the study period, including 400 girls. Among them, 63 girls were diagnosed with an ovarian prolapsed hernia. SILPEC was successfully performed through a single port in all cases, with a single exception, in whom the forceps was inserted directly through the right lower quadrant to pull up the ovary. The duration of surgery in the prolapse group was not higher than that in the non-prolapse group. During the SILPEC surgery, the ovaries were successfully reverted into the abdominal cavity by external compression of the inguinal area alone in 38 of the 63 patients. In the remaining 25 cases, the ovaries were reverted into the abdominal cavity by external compression of the inguinal area and traction of the round ligament with forceps. None of these cases failed to return to the ovaries. Conclusion: Our study results indicate that SILPEC may be performed safely for the treatment of ovarian prolapsed inguinal hernia. Since the ovary and fallopian tube are close to the internal inguinal ring due to the short round ligament, the procedure requires careful suturing with traction of the round ligament.

    DOI: 10.1007/s00464-021-08777-4

    Web of Science

    Scopus

    PubMed

  5. Double-balloon endoscopic retrograde cholangiography can make a reliable diagnosis and good prognosis for postoperative complications of congenital biliary dilatation Reviewed

    Shirota Chiyoe, Kawashima Hiroki, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Amano Hizuru, Takimoto Aitaro, Hinoki Akinari, Uchida Hiroo

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 11052   2021.5

     More details

    Language:English   Publisher:Scientific Reports  

    Bile duct and anastomotic strictures and intrahepatic stones are common postoperative complications of congenital biliary dilatation (CBD). We performed double-balloon endoscopic retrograde cholangiography (DBERC) for diagnostic and therapeutic purposes after radical surgery. We focused on the effectiveness of DBERC for the treatment of postoperative complications of CBD patients. Bile duct and anastomotic strictures and intrahepatic stones are common postoperative complications of congenital biliary dilatation (CBD). We performed double-balloon endoscopic retrograde cholangiography (DBERC) for diagnostic and therapeutic purposes after radical surgery. We focused on the effectiveness of DBERC for the treatment of postoperative complications of CBD patients. This retrospective study included 28 patients who underwent DBERC (44 procedures) after radical surgery for CBD between January 2011 and December 2019. Strictures were diagnosed as “bile duct strictures” if endoscopy confirmed the presence of bile duct mucosa between the stenotic and anastomotic regions, and as “anastomotic strictures” if the mucosa was absent. The median patient age was 4 (range 0–67) years at the time of primary surgery for CBD and 27.5 (range 8–76) years at the time of DBERC. All anastomotic strictures could be treated with only by 1–2 courses of balloon dilatation of DBERC, while many bile duct strictures (41.2%) needed ≥ 3 treatments, especially those who underwent operative bile duct plasty as the first treatment (83.3%). Although the study was limited by the short follow-up period after DBERC treatment, DBERC is recommended as the first-line treatment for hepatolithiasis associated with biliary and anastomotic strictures in CBD patients, and it can be safely performed multiple times.

    DOI: 10.1038/s41598-021-90550-7

    Web of Science

    Scopus

    PubMed

  6. Multicenter, retrospective, comparative study of laparoscopic and open Kasai portoenterostomy in children with biliary atresia from Japanese high-volume centers Reviewed

    Murase Naruhiko, Hinoki Akinari, Shirota Chiyoe, Tomita Hirofumi, Shimojima Naoki, Sasaki Hideyuki, Nio Masaki, Tahara Kazunori, Kanamori Yutaka, Shinkai Masato, Yamamoto Hirotoshi, Sugawara Yasuhiko, Hibi Taizo, Ishimaru Tetsuya, Kawashima Hiroshi, Koga Hiroyuki, Yamataka Atsuyuki, Uchida Hiroo

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 26 ( 1 ) page: 43 - 50   2019.1

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Journal of Hepato-Biliary-Pancreatic Sciences  

    Background: Multicenter study was undertaken to analyze the results of laparoscopic and open Kasai portoenterostomy. Methods: Subjects were infants with type III biliary atresia who underwent open operation (n = 106) or laparoscopic operation (n = 21) between January 2012 and December 2015. Clinical data were compared between open and laparoscopic operations (2016-0534). Propensity score matching was performed to reduce the effect of treatment selection bias. Multivariate analyses were used to estimate the effect of the surgical approach on the jaundice clearance rate and the native liver survival rate. Results: The postoperative jaundice clearance rate and the 1-year native liver survival rate were not significantly different between open and laparoscopic operations. Rates of cholangitis and major complications of laparoscopic operation were comparable to those of open operation. Blood loss, time to resume oral intake, time to drain removal, and duration of analgesic usage of laparoscopic operation were significantly superior to those of open operation. Similar results were observed when analysis was adjusted based on propensity score. Multivariate analyses demonstrated that only age at operation was a poor prognostic factor. Conclusion: Laparoscopic Kasai portoenterostomy was associated with several favorable perioperative outcomes compared with open Kasai portoenterostomy. The difference of surgical approach was not a significant independent predictor.

    DOI: 10.1002/jhbp.594

    Web of Science

    Scopus

    PubMed

  7. Usefulness of fetal magnetic resonance imaging for postnatal management of congenital lung cysts: prediction of probability for emergency surgery Reviewed

    Shirota Chiyoe, Tainaka Takahisa, Nakane Toshiki, Tanaka Yujiro, Hinoki Akinari, Sumida Wataru, Murase Naruhiko, Oshima Kazuo, Chiba Kosuke, Shirotsuki Ryo, Uchida Hiroo

    BMC PEDIATRICS   Vol. 18 ( 1 ) page: 105   2018.3

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:BMC Pediatrics  

    Background: Emergency rescue lung resection is rarely performed to treat congenital lung cysts (CLCs) in neonates. Many reports have described fetal CLC treatment; however, prenatal predictors for postnatal respiratory failure have not been characterized. We hypothesized that fetal imaging findings are useful predictors of emergency surgery. Methods: We retrospectively studied patients with CLC who underwent lung surgery during the neonatal period in our hospital between January 2001 and December 2015. The demographic data, fetal imaging findings, and intra- and postoperative courses of patients who underwent emergency surgery (Em group) were compared with those of patients who received elective surgery, i.e., non-emergency surgery (Ne group). Results: The Em group and Ne group included 7 and 11 patients, respectively. No significant difference was noted in gestational age, time at prenatal diagnosis, birth weight, and body weight at surgery. The volumes of contralateral lung per thoracic volume were significantly smaller in the Em group than in the Ne group (p = 0.0188). Mediastinal compression was more common in the Em group (7/7) than in the Ne group (4/11) (p = 0.0128). Conclusions: This is the report describing neonatal emergency lobectomy in patients with CLC evaluated by fetal MRI using the lung volume ratio and mediastinal shift. In patients with CLC, mediastinal shift and significant decreases in contralateral lung volumes during the fetal stages are good prenatal predictors of postnatal emergency lung resection.

    DOI: 10.1186/s12887-018-1085-z

    Web of Science

    Scopus

    PubMed

  8. Laparoscopic resection of neuroblastomas in low- to high-risk patients without image-defined risk factors is safe and feasible. Reviewed

    Shirota C, Tainaka T, Uchida H, Hinoki A, Chiba K, Tanaka Y

    BMC pediatrics   Vol. 17 ( 1 ) page: 71   2017.3

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12887-017-0826-8

    Web of Science

    Scopus

    PubMed

  9. New Navigation Surgery for Resection of Lymphatic Malformations Using Indocyanine Green Fluorescence Imaging. Reviewed

    Shirota C, Hinoki A, Takahashi M, Tanaka Y, Tainaka T, Sumida W, Murase N, Oshima K, Shirotsuki R, Chiba K, Morimoto Y, Uchida H

    The American journal of case reports   Vol. 18   page: 529 - 531   2017.5

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.12659/AJCR.903465

    Web of Science

    Scopus

    PubMed

  10. Prolonged survival of porcine hepatocytes in cynomolgus monkeys. Reviewed

    Nagata H, Nishitai R, Shirota C, Zhang JL, Koch CA, Cai J, Awwad M, Schuurman HJ, Christians U, Abe M, Baranowska-Kortylewicz J, Platt JL, Fox IJ

    Gastroenterology   Vol. 132 ( 1 ) page: 321-9   2007.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1053/j.gastro.2006.10.013

    PubMed

  11. Route of hepatocyte delivery affects hepatocyte engraftment in the spleen. Reviewed

    Nagata H, Ito M, Shirota C, Edge A, McCowan TC, Fox IJ

    Transplantation   Vol. 76 ( 4 ) page: 732-4   2003.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/01.TP.0000081560.16039.67

    PubMed

  12. A Retrospective Study on the Effect of Surgical Experiences of Laparoscopic Kasai Portenterostomy Reviewed

    Kurano Yui, Shirota Chiyoe, Hinoki Akinari, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Uchida Hiroo

    Journal of the Japanese Society of Pediatric Surgeons   Vol. 57 ( 3 ) page: 596 - 599   2021.4

     More details

    Authorship:Corresponding author   Language:Japanese   Publisher:The Japanese Society of Pediatric Surgeons  

    <p><i>Purpose</i>: The treatment outcomes of patients with laparoscopic surgery for biliary atresia (laparoscopic portoenterostomy) were retrospectively evaluated to determine whether to limit the laparoscopic surgery for biliary atresia to fully experienced surgeons.</p><p><i>Methods</i>: We included 37 patients with laparoscopic portoenterostomy for biliary atresia at our institution from 2014 to 2018. Twelve patients were treated by a surgeon fully experienced in laparoscopic portoenterostomy (Group A) and 23 patients were treated by other surgeons (Group B). Jaundice reduction and jaundice-free survival of patients with the native liver in the two groups were compared.</p><p><i>Results</i>: Differences in age at the time of surgery, body weight, perioperative blood loss, time of drain removal, and time that milk or formula feeding resumed in both groups were not significant. The duration of surgery was significantly shorter in Group A than in Group B. The jaundice-free survival rates of patients with the native liver were 58.3% in Group A and 60.9% in Group B at 6 months after surgery, 66.7% in Group A and 65.2% in Group B at 1 year after surgery, and 58.3% in Group A and 56.5% in Group B at 2 years after surgery. No significant difference was observed.</p><p><i>Conclusions</i>: In this study, no significant difference in the rate of jaundice-free survival of patients with the native liver depending on the amount of surgical experience was observed under the guidance of an operator who was skilled in laparoscopic portoenterostomy.</p>

    DOI: 10.11164/jjsps.57.3_596

    CiNii Research

  13. Late postoperative complications of congenital biliary dilatation in pediatric patients: a single-center experience of managing complications for over 20 years

    Amano Hizuru, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Tanaka Yujiro, Hinoki Akinari, Kawashima Hiroki, Uchida Hiroo

    SURGERY TODAY   Vol. 51 ( 9 ) page: 1488 - 1495   2021.9

     More details

    Language:Japanese   Publisher:Surgery Today  

    Purpose: To investigate late complications after surgery for congenital biliary dilatation (CBD). Methods: We retrospectively reviewed the patients treated for late postoperative complications of extrahepatic bile duct resection with bilioenteric anastomosis for CBD at our hospital between 1999 and 2019. Results: Twenty-seven complications, including bile duct stenosis with (n = 19) or without (n = 3) hepatolithiasis, remnant intrapancreatic bile duct (n = 2), intestinal obstruction (n = 2), and refractory cholangitis (n = 1) were treated in 26 patients. The median age at radical surgery and the initial treatment of complications was 3 years, 2 months and 14 years, 5 months, respectively. The median period from radical surgery to initial treatment of complications was 7 years, 1 month. Before 2013, bile duct stenosis was initially treated with bile duct plasty (n = 11) or hepatectomy (n = 3), and 71.4% (n = 10) of patients needed further treatment; after 2013, double-balloon endoscopic retrograde cholangiography (DBERC) was used (n = 8), and 25% (n = 2) of patients needed further treatment. Patients with remnant intrapancreatic bile duct, intestinal obstruction, and refractory cholangitis required surgery. Conclusion: Long-term follow-up is necessary after surgery for congenital biliary dilatation. DBERC is thus considered to be useful for bile duct stenosis management.

    DOI: 10.1007/s00595-021-02238-0

    Web of Science

    Scopus

    PubMed

  14. Biodegradable Surgical Staple Composed of Magnesium Alloy Reviewed

    Amano Hizuru, Hanada Kotaro, Hinoki Akinari, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Murase Naruhiko, Oshima Kazuo, Chiba Kosuke, Tanaka Yujiro, Uchida Hiroo

    SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page: 14671   2019.10

     More details

    Language:Japanese   Publisher:Scientific Reports  

    Currently, surgical staples are composed of non–biodegradable titanium (Ti) that can cause allergic reactions and interfere with imaging. This paper proposes a novel biodegradable magnesium (Mg) alloy staple and discusses analyses conducted to evaluate its safety and feasibility. Specifically, finite element analysis revealed that the proposed staple has a suitable stress distribution while stapling and maintaining closure. Further, an immersion test using artificial intestinal juice produced satisfactory biodegradable behavior, mechanical durability, and biocompatibility in vitro. Hydrogen resulting from rapid corrosion of Mg was observed in small quantities only in the first week of immersion, and most staples maintained their shapes until at least the fourth week. Further, the tensile force was maintained for more than a week and was reduced to approximately one-half by the fourth week. In addition, the Mg concentration of the intestinal artificial juice was at a low cytotoxic level. In porcine intestinal anastomoses, the Mg alloy staples caused neither technical failure nor such complications as anastomotic leakage, hematoma, or adhesion. No necrosis or serious inflammation reaction was histopathologically recognized. Thus, the proposed Mg alloy staple offers a promising alternative to Ti alloy staples.

    DOI: 10.1038/s41598-019-51123-x

    Web of Science

    Scopus

    PubMed

  15. Novel thoracoscopic navigation surgery for neonatal chylothorax using indocyanine-green fluorescent lymphography

    Shirotsuki Ryo, Uchida Hiroo, Tanaka Yujiro, Shirota Chiyoe, Yokota Kazuki, Murase Naruhiko, Hinoki Akinari, Oshima Kazuo, Chiba Kosuke, Sumida Wataru, Hayakawa Masahiro, Tainaka Takahisa

    JOURNAL OF PEDIATRIC SURGERY   Vol. 53 ( 6 ) page: 1246 - 1249   2018.6

     More details

    Language:Japanese   Publisher:Journal of Pediatric Surgery  

    Background: Postoperative chylothorax after surgery for esophageal atresia/tracheoesophageal fistula (TEF) is a rare but serious complication, especially in neonates. This study aimed to identify the thoracic duct and ligate chylous leakage sites, using thoracoscopic navigation of an indocyanine-green (ICG)-based near-infrared (NIR) fluorescence imaging system. Methods: From November 2014 to April 2017, thoracoscopic intraoperative ICG-NIR imaging was performed in 10 newborns (11 surgeries) with first TEF operation or with persistent postoperative chylothorax after TEF operation. NIR imaging was performed 1 h after an inter-toe injection of ICG. Thoracoscopic ligations against the NIR-detected leakage sites were performed with sutures. Results: The thoracic duct or lymphatic leakage was directly visualized in each patient. In 8 surgeries with first thoracoscopic TEF operation, one case had suspected minor chylous leakage without postoperative chylothorax. Another case with no chylous leakage at the first operation resulted in chylothorax at postoperative day 11. In three neonates with postoperative chylothorax, leakage points were detected near the ablation site of the azygos vein during the first operation. These points were properly ligated, and postoperative chylous leakage ceased with no adverse events. Conclusions: Thoracoscopic ICG-NIR imaging encourages the repair of refractory chylothorax and seems reliable. Level of Evidence: IV

    DOI: 10.1016/j.jpedsurg.2018.01.019

    Web of Science

    Scopus

    PubMed

  16. Initial treatment of septated parapneumonic empyema with drainage plus fibrinolytic agents is equally effective as video-assisted thoracoscopic surgery, and is suitable as first-line therapy. Reviewed

    Shirota C, Uchida H

    Translational pediatrics   Vol. 4 ( 1 ) page: 41-4   2015.1

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3978/j.issn.2224-4336.2015.02.01

    PubMed

  17. NOVEL BIOMARKER DISCOVERY FOR CHILDHOOD RHABDOMYOSARCOMA USING URINARY METABOLITES

    Amano Hizuru, Hinoki Akinari, Uchida Hiroo, Yokota Kazuki, Ishigaki Takashi, Sakairi Minoru, Abe Mayumi, Terui Yasushi, Oda Hirohisa, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Kano Yoko, Okamoto Masamune, Yasui Akihiro, Nakagawa Yoichi

    PEDIATRIC BLOOD & CANCER   Vol. 68   page: S46 - S46   2021.6

     More details

    Language:Japanese  

    Web of Science

  18. Identification of novel neuroblastoma biomarkers in urine samples

    Yokota Kazuki, Uchida Hiroo, Sakairi Minoru, Abe Mayumi, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Oshima Kazuo, Makita Satoshi, Amano Hizuru, Hinoki Akinari

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 4055   2021.2

     More details

    Language:Japanese   Publisher:Scientific Reports  

    Urine is a complex liquid containing numerous small molecular metabolites. The ability to non-invasively test for cancer biomarkers in urine is especially beneficial for screening child patients. This study attempted to identify neuroblastoma biomarkers by comprehensively analysing urinary metabolite samples from children. A total of 87 urine samples were collected from 54 participants (15 children with neuroblastoma and 39 without cancer) and used to perform a comprehensive analysis. Urine metabolites were extracted using liquid chromatography/mass spectrometry and analysed by Metabolon, Inc. Biomarker candidates were extracted using the Wilcoxon rank sum test, random forest method (RF), and orthogonal partial least squares discriminant analysis (OPLS-DA). RF identified three important metabolic pathways in 15 samples from children with neuroblastoma. One metabolite was selected from each of the three identified pathways and combined to create a biomarker candidate (3-MTS, CTN, and COR) that represented each of the three pathways; using this candidate, all 15 cases were accurately distinguishable from the control group. Two cases in which known biomarkers were negative tested positive using this new biomarker. Furthermore, the predictive value did not decrease in cases with a low therapeutic effect. This approach could be effectively applied to identify biomarkers for other cancer types.

    DOI: 10.1038/s41598-021-83619-w

    Web of Science

    Scopus

    PubMed

  19. Evaluation of minimally invasive surgical skills training: comparing a neonatal esophageal atresia/tracheoesophageal fistula model with a dry box. Reviewed

    Deie K, Nakagawa Y, Uchida H, Hinoki A, Shirota C, Tainaka T, Sumida W, Yokota K, Makita S, Fujiogi M, Okamoto M, Takimoto A, Yasui A, Takada S, Maeda T

    Surgical endoscopy     2022.3

     More details

    Language:English  

    DOI: 10.1007/s00464-022-09185-y

    PubMed

  20. Laparoscopic Kasai portoenterostomy can be a standard surgical procedure for treatment of biliary atresia. Reviewed

    Shirota C, Hinoki A, Tainaka T, Sumida W, Kinoshita F, Yokota K, Makita S, Amano H, Nakagawa Y, Uchida H

    World journal of gastrointestinal surgery   Vol. 14 ( 1 ) page: 56 - 63   2022.1

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4240/wjgs.v14.i1.56

    PubMed

  21. Investigation of the feasibility and safety of single-stage anorectoplasty in neonates with anovestibular fistula Reviewed

    Shirota Chiyoe, Suzuki Keisuke, Uchida Hiroo, Kawashima Hiroshi, Hinoki Akinari, Tainaka Takahisa, Sumida Wataru, Murase Naruhiko, Oshima Kazuo, Chiba Kosuke, Makita Satoshi, Tanaka Yujiro

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 34 ( 10 ) page: 1117 - 1120   2018.10

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Pediatric Surgery International  

    Purpose: Anovestibular fistula (AVF) is the most common type of anorectal malformation in females. Delayed anorectoplasty with fistula dilatation is commonly performed during infancy; however, we have been actively performing anorectoplasty in neonates. We report the surgical complications and postoperative defecation function associated with single-stage anorectoplasty performed in neonates. Methods: Patients who underwent surgery for AVF between 2007 and 2017 at two institutions were retrospectively studied. The operation time, amount of bleeding, time to start oral intake, perioperative complications, and Kelly’s score were compared among patients who underwent surgery as neonates and those who underwent surgery as infants. Results: Eighteen neonates and 17 infants underwent anterior sagittal anorectoplasty. The median operation time and time to start oral intake were significantly shorter in the neonatal group (72 min; 3 days, respectively) than in the infant group (110 min, p = 0.0002; 5 days, p = 0.0024, respectively). Postoperative wound disruption was significantly more frequent in the infant group. Of the ten patients each in the neonatal and infant groups, there was no significant difference in Kelly’s score at age ≥ 4 years. Conclusion: Single-stage anorectoplasty in neonates with AVF can be feasibly performed and does not impair postoperative defecation function. Levels of evidence: III.

    DOI: 10.1007/s00383-018-4324-3

    Web of Science

    Scopus

    PubMed

  22. Utility of endoscopic retrograde cholangiopancreatography in management of pediatric pancreaticobiliary disease

    Makita Satoshi, Amano Hizuru, Kawashima Hiroki, Hinoki Akinari, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Nakagawa Yoichi, Uchida Hiroo

    BMC PEDIATRICS   Vol. 22 ( 1 ) page: 134   2022.3

     More details

    Language:Japanese   Publisher:BMC Pediatrics  

    Background: The purpose of this study was to evaluate the utility of endoscopic retrograde cholangiopancreatography (ERCP) in pediatric patients with pancreaticobiliary diseases. Methods: A retrospective review was performed on patients who underwent ERCP for the treatment of biliary tract disease and detailed examination of pancreatitis at our institution from January 1999 to December 2020. Results: ERCP was performed for congenital biliary dilatation (CBD) (n = 42), choledocholithiasis (n = 9), common bile duct stenosis (n = 1), and several types of pancreatitis (n = 13). The only severe complication of ERCP was common bile duct injury. Three (5.8%) of 52 biliary diseases failed to be treated by ERCP. All patients with pancreatic disease were correctly diagnosed and treated. Conclusions: Endoscopic biliary drainage with a temporary stent was adequate for symptomatic relief in CBD. Stenting of the pancreatic duct was useful for improving the angulation and drainage of the pancreatic duct. ERCP was useful for understanding the anatomy of the pancreatic duct and revealing potential treatments. Therefore, ERCP and transendoscopic therapy are sufficiently feasible in pediatric patients and should be actively introduced for the investigation and treatment of pancreaticobiliary diseases.

    DOI: 10.1186/s12887-022-03207-3

    Web of Science

    Scopus

    PubMed

  23. Laparoscopic definitive surgery for congenital biliary dilatation with aggressive hilar bile ductoplasty and complete resection of the intrapancreatic bile duct in pediatric patients is safe and effective, comparable to open surgery

    Tainaka Takahisa, Shirota Chiyoe, Hinoki Akinari, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Amano Hizuru, Tanaka Yujiro, Uchida Hiroo

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES     2022.2

     More details

    Language:Japanese   Publisher:Surgical Endoscopy  

    Background: After surgery for congenital biliary dilatation (CBD), hilar and hepatic bile duct stenosis and intrapancreatic bile duct remnants can cause many postoperative complications. We investigated the efficacy of laparoscopic surgery with aggressive bile ductoplasty and complete excision of the intrapancreatic bile duct in CBD patients compared to open surgery. Methods: Pediatric patients who underwent surgery for CBD at our institution between 2006 and 2020 were divided into two groups: laparoscopic surgery (Lap group) and open surgery (Op group). Surgical outcomes were compared between the two groups. Results: We enrolled 160 patients (85 in the Lap group and 75 in the Op group). Hilar bile ductoplasty was performed in 52 (61%) patients from the Lap group and 40 (53%) patients from the Op group. The operative time was significantly longer, the amount of blood loss was significantly lower, and the length of hospital stay was significantly shorter in the Lap group than in the Op group. Postoperative early and late complications occurred at a similarly low rate in both groups. When the surgical outcomes were compared between the group who underwent laparoscopic bile ductoplasty and the group that did not, postoperative early and late complications occurred similarly in both groups. Conclusions: Laparoscopic surgery for CBD with aggressive hilar bile ductoplasty and complete excision of the intrapancreatic bile duct is safe and effective, comparable to open surgery. However, it is necessary to verify whether long-term occurrence of hepatolithiasis similar to open definitive surgery can be obtained in the future.

    DOI: 10.1007/s00464-022-09132-x

    Web of Science

    Scopus

    PubMed

  24. Safety and feasibility of primary radical surgery for meconium peritonitis considering patients' general condition and perioperative findings

    Nakagawa Yoichi, Uchida Hiroo, Amano Hizuru, Hinoki Akinari, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Takada Shunya, Maeda Takuya

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 1 ) page: 148 - 154   2022.2

     More details

    Language:Japanese   Publisher:Nagoya Journal of Medical Science  

    We reviewed the outcomes of meconium peritonitis and evaluated the safety and feasibility of primary radical surgery for meconium peritonitis. A total of 21 cases of meconium peritonitis between 2006 and 2020 were retrospectively reviewed. The patients were classified into two groups based on the type of surgery: group I (primary radical surgery, n = 16) and group II (multistage surgery; drainage only or ileostomy, followed by elective surgery, n = 5). Patient backgrounds and surgical outcomes were compared between the two groups. The term of prenatal diagnosis, preoperative white blood cell count, and preoperative catecholamine use were not significantly different between the two groups. Group I included more mature neonates than group II (gestational age at birth, 35w1d vs 30w1d, p = 0.02; birth weight, 2.5 kg vs 1.1 kg, p < 0.01). Preoperative C-reactive protein was significantly lower in group I (0.37 mg/dL vs 2.8 mg/dL, p < 0.05). Operation time, blood loss, time to enteral feeding, and complication rates were not significantly different between the two groups. The surgical outcomes of primary radical surgery were comparable to those of multistage surgery, although the patients’ backgrounds were different. Our strategy of selecting one-stage or multiple-stage surgery for treatment of meconium peritonitis, depending on the patient’s general condition and degree of intestinal ischemia, was reasonable.

    DOI: 10.18999/nagjms.84.1.148

    Web of Science

    Scopus

  25. Clinical characteristics and outcomes of the right congenital diaphragmatic hernia compared to the left: a 10-year single-center experience

    Okamoto Masamune, Amano Hizuru, Uchida Hiroo, Hinoki Akinari, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Yasui Akihiro, Nakagawa Yoichi

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 12 ) page: 1675 - 1681   2021.12

     More details

    Language:Japanese   Publisher:Pediatric Surgery International  

    Purpose: The features of right-sided congenital diaphragmatic hernias (RCDHs) are quite different from those of left-sided CDHs (LCDHs). We have summarized the features of RCDHs experienced in our institution. Methods: This retrospective study analyzed the cases of patients with CDH registered at our institution between 2011 and 2020. Defects on each side were compared based on prenatal diagnosis, medical treatment, type of surgery, and outcomes. Results: A total of 101 patients underwent surgery at our institution during the neonatal period, and 11 had RCDHs. RCDHs and LCDHs were significantly different in terms of extracorporeal membrane oxygenation (36% vs. 6%, p = 0.002), patch repair (81% vs. 28%, p < 0.001), recurrence rate (36% vs. 11%, p = 0.022), and length of hospital stay (117 days vs. 51 days, p = 0.012). The severity of the fetal diagnosis did not reflect postnatal severity. All patients with RCDH survived to discharge, and there was no significant difference in survival rate between the right and left sides. Conclusion: Neonates with RCDH required more intensive treatments; however, the survival rate was comparable between RCDH and LCDH. RCDH was significantly different from LCDH and an optimal treatment strategy for RCDHs should be established.

    DOI: 10.1007/s00383-021-04999-8

    Web of Science

    Scopus

    PubMed

  26. An imaging study on tracheomalacia in infants with esophageal atresia: the degree of tracheal compression by the brachiocephalic artery is a good indicator for therapeutic intervention

    Sumida Wataru, Tainaka Takahisa, Shirota Chiyoe, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Yasui Akihiro, Okamoto Masamune, Nakagawa Yoichi, Hinoki Akinari, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 12 ) page: 1719 - 1724   2021.12

     More details

    Language:Japanese   Publisher:Pediatric Surgery International  

    Purpose: Tracheomalacia (TM) is a frequent complication after esophageal atresia (EA) repair. This study aimed to review patients who underwent aortopexy for TM after EA repair and to compare their imaging features. Methods: The patients who underwent thoracoscopic EA repair and contrast-enhanced computed tomography (CECT) at our hospital between 2013 and 2020 were retrospectively reviewed. The ratio of the lateral and anterior–posterior diameter of the trachea (LAR) where the brachiocephalic artery (BCA) crosses the trachea was defined. The LAR of the patients who underwent CECT for asymptomatic pulmonary disease was set as a normal reference. The Z-score of each LAR was calculated and compared between the patients that did or did not undergo aortopexy. Results: A total of 51 patients represented the controls, 5 patients underwent aortopexy, and 12 patients were discharged without surgery. The mean LARs in the patients who underwent aortopexy, did not undergo aortopexy, and controls were 3.54, 1.54, and 1.15, respectively. The mean Z-score of the aortopexy group was 21.2. After successful aortopexy, each patient’s LAR decreased to < 1.5. Conclusion: Aortopexy was preferred if the trachea was compressed by the BCA. The LAR is a useful indicator for predicting the therapeutic effect of aortopexy.

    DOI: 10.1007/s00383-021-04985-0

    Web of Science

    Scopus

    PubMed

  27. Urinary N-1,N-12-diacetylspermine as a biomarker for pediatric cancer: a case-control study

    Yokota Kazuki, Hinoki Akinari, Hiramatsu Kyoko, Amano Hizuru, Kawamura Machiko, Kuwatsuka Yachiyo, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Nakagawa Yoichi, Uchida Hiroo, Kawakita Masao

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 12 ) page: 1659 - 1665   2021.12

     More details

    Language:Japanese   Publisher:Pediatric Surgery International  

    Purpose: Minimally invasive examinations are particularly important in pediatric patients. Although the significance of urinary N1,N12-diacetylspermine (DiAcSpm) as a tumor marker (TM) has been reported in many types of adult cancers, its usefulness in pediatric cancers has not been reported. This may be due to urinary DiAcSpm level variations with age. This study aims to measure the normal levels of urinary DiAcSpm in healthy individuals and investigate its usefulness as a TM in childhood cancer. Methods: Urinary samples were collected from pediatric patients with and without cancer. The urinary DiAcSpm levels were measured, and the values were compared. Results: A total of 32 patients with cancer and 405 controls were enrolled in the study. Of the 32 patients, 13 had neuroblastoma, 9 had malignant lymphoma (ML), and 10 had leukemia. In the control group, the urinary DiAcSpm values markedly fluctuated among those with young age, especially infants; meanwhile, the values converged among those aged roughly 10 years and above. The sensitivity of DiAcSpm was significantly different among the three types of cancers: neuroblastoma (30.8%), ML (77.8%), and leukemia (40%). Conclusion: The urinary DiAcSpm value is a useful TM for both screening and follow-up of ML.

    DOI: 10.1007/s00383-021-04987-y

    Web of Science

    Scopus

    PubMed

  28. Long-term outcomes of the partial splenectomy for hypersplenism after portoenterostomy of patients with biliary atresia

    Tainaka Takahisa, Hinoki Akinari, Tanaka Yujiro, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Oshima Kazuo, Amano Hizuru, Takimoto Aitaro, Kano Yoko, Uchida Hiroo

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 4 ) page: 765 - 771   2021.11

     More details

    Language:Japanese   Publisher:Nagoya Journal of Medical Science  

    Massive splenomegaly and hypersplenism in patients with biliary atresia after Kasai portoenterostomy were treated with partial splenic embolization or total splenectomy. We performed partial splenectomy to reduce the complications of partial splenic embolization and avoid overwhelming post-splenectomy infection. This study aimed to evaluate the long-term effects of partial splenectomy for hypersplenism on postoperative liver and spleen function in patients with biliary atresia. Among jaundice-free patients with biliary atresia who underwent Kasai portoenterostomy between January 1992 and December 2012, 15 underwent partial splenectomy for massive splenomegaly and hypersplenism at our institution. Changes in the laboratory data 10 years post partial splenectomy were retrospectively investigated, and these along with the latest data were measured. A total of four patients (27%) required living-donor liver transplantation after partial splenectomy, a proportion similar to those who did not undergo partial splenectomy. Compared to the preoperative baseline, the platelet counts were significantly higher at 1 and 3 years after surgery (p < 0.05). Aspartic aminotransferase-to-platelet ratio index was significantly lower at 1, 7, and 10 years after partial splenectomy (p < 0.05). No further surgeries were required for hypersplenism after partial splenectomy over 10 years, and there were no cases of overwhelming post-splenectomy infection after partial splenectomy. Partial splenectomy is safe and effective for the treatment of hypersplenism with biliary atresia over a long time period. It could be considered as an alternative to partial splenic embolization as it can suppress hypersplenism for a long time and induces fewer postoperative complications.

    DOI: 10.18999/nagjms.83.4.765

    Web of Science

    Scopus

    PubMed

  29. Factors associated with bleeding after endoscopic variceal ligation in children

    Yokoyama Shinya, Ishizu Yoji, Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ito Takanori, Hinoki Akinari, Sumida Wataru, Shirota Chiyoe, Tainaka Takahisa, Makita Satoshi, Yokota Kazuki, Uchida Hiroo, Fujishiro Mitsuhiro

    PEDIATRICS INTERNATIONAL   Vol. 63 ( 10 ) page: 1223 - 1229   2021.10

     More details

    Language:Japanese   Publisher:Pediatrics International  

    Background: Endoscopic variceal ligation (EVL) is a widely accepted treatment for esophagogastric varices in patients with portal hypertension (PHT). It is used for urgent treatment and prophylactic treatment of esophagogastric varices in pediatric as well as adult patients. However, major life-threatening adverse events such as early rebleeding can occur. Although early rebleeding after EVL among children and adolescents has been reported, the risk factors remain obscure. This study evaluated the risk factors for early rebleeding after EVL in children and adolescents. Methods: The subjects were children and adolescents (<18 years) with PHT who underwent EVL for esophagogastric varices. Early rebleeding was defined as hematemesis, active bleeding, or blood retention in the stomach, confirmed by esophagogastroduodenoscopy from 2 h to 5 days after EVL. Results: A total of 50 EVL sessions on 22 patients were eligible for this study. There were four episodes of early rebleeding. No other major adverse event has occurred. Multivariate analysis showed that EVL implemented at cardiac varices just below the esophagogastric junction (EGJ), within 5 mm from the EGJ, is the independent factor for a higher risk of early rebleeding: odds ratio 18.2 (95% confidence interval: 1.40–237.0), P = 0.02. Conclusions: Children and adolescents who undergo EVL for cardiac varices just below the EGJ have a higher risk of early rebleeding than those who do not.

    DOI: 10.1111/ped.14614

    Web of Science

    Scopus

    PubMed

  30. Laparoscopic One-Stage Radical Surgery for Congenital Biliary Dilatation With Biliary Perforation

    Ishii Hiroki, Makita Satoshi, Yasui Akihiro, Takimoto Aitaro, Yokota Kazuki, Sumida Wataru, Tainaka Takahisa, Shirota Chiyoe, Uchida Hiroo

    Journal of the Japanese Society of Pediatric Surgeons   Vol. 57 ( 5 ) page: 855 - 859   2021.8

     More details

    Language:Japanese   Publisher:The Japanese Society of Pediatric Surgeons  

    <p>A 21-month-old girl with chief complaints of vomiting and fever was admitted to a hospital and diagnosed as having congenital biliary dilatation. Magnetic resonance imaging performed on the sixth day of hospitalization revealed bile duct perforation, and the patient was transferred to our department for further treatment. A perforation approximately 2 cm in diameter was found at the confluence of the common bile duct and cystic duct. We concluded that biliary drainage and repair of the perforation would not improve her pathophysiology. Therefore, laparoscopic one-stage radical surgery was performed. In addition, bile duct plasty was performed to treat the severe intrahepatic bile duct membranous stenosis that were observed in the right and left bile ducts of the hepatic hilum. The patient was discharged without complications on the tenth postoperative day.</p><p>Two-stage surgery is the recommended treatment method for congenital biliary dilatation with biliary perforation. However, in recent years, there have been few reports showing that one-stage open radical surgery is useful. In this case, we successfully performed laparoscopic one-stage radical surgery for congenital biliary dilatation with biliary perforation. If laparoscopic radical surgery for congenital biliary dilatation is established at the institution, and the patient is in good general condition, laparoscopic one-stage radical surgery may be an effective modality for treating this condition.</p>

    DOI: 10.11164/jjsps.57.5_855

    CiNii Research

  31. Development of a novel diagnostic system for bile duct cancer using urinary metabolites.

    Amano Hizuru, Hinoki Akinari, Uchida Hiroo, Yokota Kazuki, Ishigaki Takashi, Sakairi Minoru, Abe Mayumi, Terui Yasushi, Oda Hirohisa, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Okamoto Masamune, Yasui Akihiro, Nakagawa Yoichi

    CANCER RESEARCH   Vol. 81 ( 13 )   2021.7

     More details

    Language:Japanese  

    Web of Science

  32. A patient with very early onset FH-deficient renal cell carcinoma diagnosed at age seven

    Taniguchi Rieko, Muramatsu Hideki, Okuno Yusuke, Yoshida Taro, Wakamatsu Manabu, Hamada Motoharu, Shirota Chiyoe, Sumida Wataru, Hinoki Akinari, Tainaka Takahisa, Gotoh Yoshimitsu, Tsuzuki Toyonori, Tanaka Yukichi, Kojima Seiji, Uchida Hiroo, Takahashi Yoshiyuki

    FAMILIAL CANCER     2021.6

     More details

    Language:Japanese   Publisher:Familial Cancer  

    Hereditary leiomyomatosis and renal cell cancer (HLRCC) is caused by heterozygous germline variants in the fumarate hydratase (FH) gene and is associated with increased susceptibility to cutaneous leiomyomas, uterine leiomyomas, and renal cell carcinoma (RCC). HLRCC-associated RCC usually occurs in the middle age, with the median age being 40–44 years. This report describes a seven-year-old (84-month-old) male who developed a large right kidney tumor with multiple cystic lesions that contained enhanced solid components. There was no evidence of distant metastasis. The male patient underwent right nephrectomy and has been recovering well without metastasis or recurrence. Pathological examination revealed that tumor cells with relatively prominent nucleoli and surrounded by halos, were located in a limited area. Immunohistochemical staining was negative for FH. Whole-exome sequencing identified his germline variant in the FH gene and its loss of heterozygosity in the tumor. At nine years (114 months) of age, the male patient showed no recurrence of the tumor. This was the youngest-onset case of HLRCC-associated RCC to date. This report may affect the starting age for future RCC-surveillance programs for patients with HLRCC.

    DOI: 10.1007/s10689-021-00268-8

    Web of Science

    Scopus

    PubMed

  33. Postoperative intestinal obstruction in patients with biliary atresia impedes biliary excretion and results in subsequent liver transplantation (vol 37, pg 229, 2021)

    Takimoto Aitaro, Sumida Wataru, Amano Hizuru, Shirota Chiyoe, Tainaka Takahisa, Yokota Kazuki, Makita Satoshi, Yasui Akihiro, Kanou Yoko, Hinoki Akinari, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 6 ) page: 835 - 835   2021.6

     More details

    Language:Japanese   Publisher:Pediatric Surgery International  

    A correction to this paper has been published: https://doi.org/10.1007/s00383-021-04873-7.

    DOI: 10.1007/s00383-021-04873-7

    Web of Science

    Scopus

    PubMed

  34. Urinary biomarkers for monitoring treatment response in neuroblastoma patients.

    Amano Hizuru, Hinoki Akinari, Uchida Hiroo, Yokota Kazuki, Ishigaki Takashi, Sakairi Minoru, Abe Mayumi, Takahashi Yoshiyuki, Narita Atsushi, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Kano Yoko, Yasui Akihiro, Okamoto Masamune, Nakagawa Yoichi

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 39 ( 15 )   2021.5

     More details

  35. One-Stage Functional End-To-End Anastomosis Followed by Sutureless Abdominal Wall Closure for Colonic Atresia With Gastroschisis

    Chiba Kosuke, Tanaka Yujiro, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Oshima Kazuo, Makita Satoshi, Uchida Hiroo

    Journal of the Japanese Society of Pediatric Surgeons   Vol. 57 ( 1 ) page: 22 - 26   2021.2

     More details

    Language:Japanese   Publisher:The Japanese Society of Pediatric Surgeons  

    <p>The patient was a newborn female with colonic atresia and gastroschisis. A silo was placed immediately after birth and surgery was scheduled the following day. Adhesive detachment was performed by washing the intestinal tract with saline. The oral and anal segments of the colonic atresia were identified, and functional end-to-end anastomosis was performed. Severe edema precluded the immediate return of the intestines to the abdominal cavity and required ongoing treatment with a silo. The intestines gradually returned to the abdominal cavity during the following week. The abdominal wall was closed on postnatal day 9 by a sutureless method. The patient’s postoperative course was good, and full feeding was initiated on postnatal day 19. The patient was discharged from the hospital on postnatal day 32 and recovered without complications. In cases of gastroschisis with colonic atresia, a two-stage surgical procedure is commonly employed. However, functional end-to-end anastomosis using a linear stapler is also an effective method because anastomoses can be performed without regard to differences in intestinal caliber.</p>

    DOI: 10.11164/jjsps.57.1_22

    CiNii Research

  36. Postoperative intestinal obstruction in patients with biliary atresia impedes biliary excretion and results in subsequent liver transplantation

    Takimoto Aitaro, Sumida Wataru, Amano Hizuru, Shirota Chiyoe, Tainaka Takahisa, Yokota Kazuki, Makita Satoshi, Yasui Akihiro, Kanou Yoko, Hinoki Akinari, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 2 ) page: 229 - 234   2021.2

     More details

    Language:Japanese   Publisher:Pediatric Surgery International  

    Purpose: This study aimed to investigate the negative effects of intestinal obstruction for jaundice-free native liver survival after Kasai portoenterostomy (PE) for biliary atresia (BA). Methods: We retrospectively reviewed the records of patients who underwent PE for BA between 2006 and 2019. We evaluated the postoperative morbidity of intestinal obstruction for up to 2 years after PE and the effects of intestinal obstruction on jaundice-free native liver survival. On the basis of their initial operation, patients were divided into open portoenterostomy (Open-PE) and laparoscopic portoenterostomy (Lap-PE) groups, and morbidity was compared. Results: Of the 87 patients reviewed, 6 (6.9%) patients developed postoperative intestinal obstruction and underwent surgery to relieve the obstruction. The morbidity of early postoperative intestinal obstruction was 1.68 per 10,000 person days. The jaundice-free native liver survival rate among patients who once achieved jaundice-free status after PE was significantly lower in the patients with intestinal obstruction compared to in those without intestinal obstruction (0% vs. 73.8%; RR = 3.81, p = 0.007). No significant differences were seen in postoperative intestinal obstructions between the Open-PE and Lap-PE groups (p = 0.242). Conclusions: Intestinal obstruction negatively impact jaundice-free native liver survival, even in patients who once achieved jaundice-free status after PE for BA.

    DOI: 10.1007/s00383-020-04807-9

    Web of Science

    Scopus

    PubMed

  37. Thoracoscopic surgery for congenital lung cysts: an attempt to limit pulmonary resection in cases of lesions involving multiple lobes Reviewed

    Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Amano Hizuru, Hinoki Akinari, Ono Yasuyuki, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 2 ) page: 213 - 221   2021.2

     More details

    Authorship:Lead author   Language:English   Publisher:Pediatric Surgery International  

    Purpose: Although we generally perform thoracoscopic lobectomy for congenital lung cysts (CLCs), we recently began performing thoracoscopic-limited pulmonary resection (segmentectomy or small partial lung resection) on relatively small lesions and on lesions involving multiple lobes. Our study aimed to determine the therapeutic outcomes of thoracoscopic CLC surgery. Methods: We retrospectively reviewed patients aged ≤ 18 years who underwent their first CLC surgery at our facility between 2013 and 2020. Results: A comparison between patients < 4 months old and those ≥ 4 months old showed no significant difference in operating time or incidence of complications. Blood loss volume (mL/kg) was significantly greater in patients < 4 months old and in patients who had undergone semi-urgent or urgent surgery. Operating time and postoperative complications were not increased in semi-urgent or urgent surgeries. There was no significant difference in operating time, blood loss volume, or postoperative complications between patients with a preoperative history of pneumonia and patients with no such history. Conclusion: In most patients, thoracoscopic surgery for CLC was safely performed. Limited pulmonary resection is considered difficult to perform thoracoscopically in children, but can be safely performed using new devices and navigation methods. Level of evidence: III.

    DOI: 10.1007/s00383-020-04793-y

    Web of Science

    Scopus

    PubMed

  38. Risk factors and outcomes of bile leak after laparoscopic surgery for congenital biliary dilatation

    Tanaka Yujiro, Tainaka Takahisa, Hinoki Akinari, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Oshima Kazuo, Makita Satoshi, Amano Hizuru, Takimoto Aitaro, Kano Yoko, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 2 ) page: 235 - 240   2021.2

     More details

    Language:Japanese   Publisher:Pediatric Surgery International  

    Purpose: One of the main causes of stricture at hepaticojejunostomy site after surgery for congenital biliary dilatation is inflammation or infection associated with bile leak. The aim of this study was to determine the risk factors and outcomes of bile leak after laparoscopic surgery. Methods: We retrospectively reviewed the demographics and outcomes of patients who underwent laparoscopic surgery for congenital biliary dilatation between September 2013 and December 2019. Data from patients with bile leak were compared to data from patients without bile leak. Results: Fourteen of 78 patients had bile leak. Hepatic duct diameter at anastomosis was the only risk factor of bile leak. Patients with the diameter ≤ 10 mm had higher incidence of bile leak than in patients with the diameter > 10 mm (P = 0.0023). Among them, bile leak occurred more frequently in patients operated on by non-qualified surgeons based on the Japan Society for Endoscopic Surgery endoscopic surgical skill qualification system than by qualified surgeons (P = 0.027). However, none of the patients with bile leak developed anastomotic stricture afterwards. Conclusion: Although good technical skill is necessary to avoid bile leak in narrow hepatic duct cases (≤ 10 mm), slight bile leak may not result in anastomotic stricture.

    DOI: 10.1007/s00383-020-04791-0

    Web of Science

    Scopus

    PubMed

  39. A novel Lugol's iodine staining technique to visualize the upper margin of the surgical anal canal intraoperatively for Hirschsprung disease: a case series

    Yokota Kazuki, Amano Hizuru, Kudo Toyoki, Yamamura Takeshi, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Nakamura Masanao, Fujishiro Mitsuhiro, Hinoki Akinari, Uchida Hiroo

    BMC SURGERY   Vol. 20 ( 1 ) page: 317   2020.12

     More details

    Language:Japanese   Publisher:BMC Surgery  

    Background: In cases of Hirschsprung disease, complete and reproducible resection of the aganglionic bowel is ideal to achieve good postoperative bowel function. Reliable identification of the upper margin of the surgical anal canal, which is the squamous-columnar junction, is necessary during transanal pull-through. Here, we describe a novel staining technique using Lugol’s iodine stain to visualize the upper margin of the surgical anal canal. Methods: Lugol’s iodine staining was performed in five patients with Hirschsprung disease treated using a single-stage laparoscopic transanal pull-through modified Swenson procedure. In two of these patients, endocytoscopic observation with ultra-high magnification was performed using methylene blue and crystal violet to mark the border of the squamous epithelium at 1 week before surgery. The alignment between the incisional line, which was revealed using Lugol’s iodine staining and endocytoscopic marking, was evaluated. Complications, including postoperative bowel dysfunction, were evaluated. Results: In all cases, Lugol’s iodine staining produced a well-demarcated line. The endocytoscopic marking of the upper margin of the surgical anal canal was aligned with the line revealed by Lugol’s iodine staining. There were no complications associated with the transanal pull-through procedure, including postoperative bowel dysfunction. Conclusions: Lugol’s iodine staining could be a safe and practical method to visualize the upper margin of the surgical anal canal intraoperatively. This finding may be useful for surgeons to make a consistent removal of the aganglionic bowel during surgery for Hirschsprung disease.

    DOI: 10.1186/s12893-020-00986-3

    Web of Science

    Scopus

    PubMed

  40. Safe diagnostic management of malignant mediastinal tumors in the presence of respiratory distress: a 10-year experience

    Tanaka Tomoko, Amano Hizuru, Tanaka Yujiro, Takahashi Yoshiyuki, Tajiri Tatsuro, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Tani Yukiko, Hinoki Akinari, Uchida Hiroo

    BMC PEDIATRICS   Vol. 20 ( 1 ) page: 292   2020.6

     More details

    Language:Japanese   Publisher:BMC Pediatrics  

    Background: The fundamental treatment for patients with pediatric malignant mediastinal tumors is chemotherapy. Therefore, accurate diagnosis is essential for selecting the appropriate chemotherapeutic regimen. However, malignant mediastinal tumors occasionally cause respiratory distress, and biopsies under general anesthesia are dangerous for such patients as invasive mechanical ventilation can aggravate airway obstruction caused by mass effect. In this study, we reviewed our 10-year diagnostic experience to evaluate the efficacy of our practices and confirm a safe diagnostic protocol for future patients. Methods: We retrospectively reviewed medical records of children with malignant mediastinal tumors diagnosed at Nagoya University Hospital from 2007 to 2018 who demonstrated respiratory distress. Respiratory distress included dyspnea, massive pleural effusion, wheezing, and hypoxemia owing to tumors. Data on sex, age at onset, primary symptoms, location of tumor, management strategy (especially the method of diagnosis and definitive diagnosis), clinical course, prognosis during the acute phase (within 3 months from the onset of respiratory symptoms), and long-term outcome were collected. Results: Twelve pediatric patients met the review criteria. There were seven anterior mediastinal tumors and five posterior mediastinal tumors. All anterior mediastinal tumors were diagnosed via bone marrow smear, thoracentesis, or core needle biopsy while maintaining spontaneous breathing. Regarding posterior tumors, two patients were diagnosed via a core needle biopsy and lymph node excisional biopsy under spontaneous breathing. Two cases were initially diagnosed solely using tumor markers. One patient with severe tracheal compression underwent tumor resection with extracorporeal membrane oxygenation stand-by. No patient died of diagnostic procedure-related complications. Conclusions: In 11 of the 12 cases reviewed, safe and accurate tumor diagnosis was accomplished without general anesthesia. A diagnostic strategy without general anesthesia considering the tumor location proved to be useful.

    DOI: 10.1186/s12887-020-02183-w

    Web of Science

    Scopus

    PubMed

  41. 術中膵管損傷に対して内視鏡的に膵管ステントを挿入した1例

    城田 千代栄, 田井中 貴久, 住田 亙, 横田 一樹, 牧田 智, 天野 日出, 滝本 愛太朗, 安井 昭洋, 石井 宏樹, 檜 顕成, 内田 広夫

    日本膵・胆管合流異常研究会プロシーディングス   Vol. 43 ( 0 ) page: 84 - 85   2020

     More details

    Language:Japanese   Publisher:日本膵・胆管合流異常研究会  

    DOI: 10.34410/jspbm.43.0_84

    CiNii Research

  42. 小児腹腔鏡手術における肝内胆管形成術

    田井中 貴久, 城田 千代栄, 住田 亙, 横田 一樹, 牧田 智, 滝本 愛太朗, 安井 昭洋, 石井 宏樹, 檜 顕成, 内田 広夫

    日本膵・胆管合流異常研究会プロシーディングス   Vol. 43 ( 0 ) page: 36 - 36   2020

     More details

    Language:Japanese   Publisher:日本膵・胆管合流異常研究会  

    DOI: 10.34410/jspbm.43.0_36

    CiNii Research

  43. Identification and Validation of Novel Non-invasive Biomarkers in Patient Urine Samples for Diagnosis of New and Recurrent Neuroblastoma

    Yokota Kazuki, Uchida Hiroo, Hinoki Akinari, Sakairi Minoru, Abe Mayumi, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Oshima Kazuo, Makita Satoshi, Takimoto Aitaro, Kano Yoko, Inada Kosuke

    PEDIATRIC BLOOD & CANCER   Vol. 66   page: S106 - S106   2019.12

     More details

    Language:Japanese  

    Web of Science

  44. Efficacy of and prognosis after steroid pulse therapy in patients with poor reduction of jaundice after laparoscopic Kasai portoenterostomy

    Tanaka Yujiro, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Oshima Kazuo, Makita Satoshi, Tanaka Tomoko, Tani Yukiko, Chiba Kosuke, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 35 ( 10 ) page: 1059 - 1063   2019.10

     More details

    Language:Japanese   Publisher:Pediatric Surgery International  

    Purpose: High-dose postoperative steroid therapy after Kasai portoenterostomy is reported to improve jaundice clearance and a strong anti-inflammatory activity might prevent fibrous tissue formation which is often observed at the porta hepatis in revision surgery. We started steroid pulse therapy for the patients with cessation of decrease in jaundice and aimed to evaluate the efficacy in this study. Methods: The demographics and outcomes of patients who underwent laparoscopic Kasai portoenterostomy and received steroid pulse therapy within 2 months postoperatively between September 2014 and December 2018 were retrospectively reviewed; the therapy was determined successful when the serum total bilirubin level decreased to or below two-thirds of the pre-therapy level after 2 weeks. Patient data in the successful group were compared with those in the unsuccessful group. Results: Steroid pulse therapy was successful in seven of 16 patients (43.8%). The percentage of patients whose serum total bilirubin level decreased to normal was significantly higher in the successful group at 3 months (85.7% vs. 11.1%, P = 0.0028) and after all (100% vs. 33.3%, P = 0.011). Conclusions: Steroid pulse therapy was effective for some patients. Unsuccessful cases may have little chances of jaundice clearance; revision Kasai portoenterostomy would be a good option.

    DOI: 10.1007/s00383-019-04537-7

    Web of Science

    Scopus

    PubMed

  45. Spleen stiffness by 2-D shear wave elastography is the most accurate predictor of high-risk esophagogastric varices in children with biliary atresia

    Yokoyama Shinya, Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ito Takanori, Hirooka Yoshiki, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Chiba Kosuke, Uchida Hiroo, Fujishiro Mitsuhiro

    HEPATOLOGY RESEARCH   Vol. 49 ( 10 ) page: 1162 - 1168   2019.10

     More details

    Language:Japanese   Publisher:Hepatology Research  

    Aim: Esophagogastric variceal hemorrhage is a cause of poor prognosis in patients with biliary atresia (BA). To prevent variceal hemorrhage, simple and reliable screening methods for high-risk esophagogastric varices (HR-EGV) are needed. We evaluated the efficacy of liver stiffness (LS) and spleen stiffness (SS) as measured by 2-D shear wave elastography (2D-SWE), which was reported to be more accurate than transient elastography, for detecting HR-EGV in children with BA. Methods: Thirty-four children with BA were enrolled. Both LS and SS were measured by 2D-SWE. The presence of large esophageal varices or esophageal varices of any size with red wale marking and/or the presence of gastric varices along the cardia were defined as HR-EGV. Clinical data were collected and previously reported prediction indices for varices were calculated. Results: Liver stiffness and SS were obtained from all patients. Fourteen patients showed HR-EGV. Significantly different variables between patients with and without HR-EGV were as follows: spleen diameter (116 mm vs. 95 mm), clinical prediction rule (104.7 vs. 124.7), King's variceal prediction score (78.8 vs. 99.4), aspartic aminotransferase-to-platelet ratio index (2.03 vs. 0.98), LS (2.63 m/s vs. 1.87 m/s), and SS (4.44 m/s vs. 3.69 m/s). The highest area under the receiver operating characteristic curve for detecting HR-EGV was that for SS (0.900), and the cut-off SS of 4.12 m/s yielded 92.9% sensitivity and 90% specificity. The intraclass correlation coefficient for intra-observer reproducibility was 0.828. Conclusions: Spleen stiffness from 2D-SWE offered the most accurate predictor of HR-EGV in BA children.

    DOI: 10.1111/hepr.13381

    Web of Science

    Scopus

    PubMed

  46. NON-INVASIVE SCREENING FOR DETECTING ESOPHAGOGASTRIC VARICES IN CHILDREN WITH BILIARY ATRESIA

    Yokoyama Shinya, Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ito Takanori, Shirota Chiyoe, Uchida Hiroo, Fujishiro Mitsuhiro

    HEPATOLOGY   Vol. 70   page: 200A - 200A   2019.10

     More details

    Language:Japanese  

    Web of Science

  47. Nuss procedure for patients with pectus excavatum with a history of intrathoracic surgery

    Takanari Keisuke, Toriyama Kazuhiro, Kambe Miki, Nakamura Yutaka, Uchibori Takafumi, Ebisawa Katsumi, Shirota Chiyoe, Tainaka Takahisa, Uchida Hiroo, Kamei Yuzuru

    JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY   Vol. 72 ( 6 ) page: 1025 - 1029   2019.6

     More details

    Language:Japanese   Publisher:Journal of Plastic, Reconstructive and Aesthetic Surgery  

    Background: The aim of this study was to demonstrate the feasibility and safety of the Nuss procedure for patients with pectus excavatum (PE) with a history of intrathoracic surgery. Patients: From April 2010 to December 2013, we performed 6 cases of PE repair in patients with a history of intrathoracic surgery. The causes of previous operations were congenital cystic adenomatoid malformation in 4 patients and congenital diaphragmatic hernia in 2. The patients’ median age was 5 years (range, 4–9 years) and median preoperative pectus severity index was 4.63 (range, 3.42–10.03). Their intraoperative and postoperative courses were reviewed retrospectively. Results: The mean overall operation time was 127.5 ± 17.0 minutes, and the mean operation time for endoscopic pneumolysis was 28.8 ± 12.3 minutes. Intraoperative exploration for pleural adhesion revealed that the endoscopic approach in the previous operation was associated with low pleural adhesion, and the open thoracotomy or laparotomy approach was associated with low to high pleural adhesion. One patient developed a pneumothorax on the first postoperative day. All the other patients had uneventful postoperative courses. All the patients received bar removal 2–3 years after bar insertion. One patient developed atelectasis after bar removal. All the other patients had an uneventful postoperative course. The mean postoperative follow-up time after bar removal was 20.1 ± 14.7 months. Conclusions: History of intrathoracic surgery seems not a contraindication for the Nuss procedure. However, perioperative complications should be carefully monitored in both the bar insertion and removal operations.

    DOI: 10.1016/j.bjps.2018.12.027

    Web of Science

    Scopus

    PubMed

  48. A Novel Laparoscopic Surgery Model with a Device to Expand the Abdominal Working Space in Rats: The Influence of Pneumoperitoneum and Skin Incision Length on Postoperative Inflammatory Cytokines.

    Murase N, Tainaka T, Uchida H, Hinoki A, Shirota C, Yokota K, Oshima K, Shirotsuki R, Chiba K, Tanaka Y

    Journal of investigative surgery : the official journal of the Academy of Surgical Research   Vol. 32 ( 1 ) page: 55 - 60   2019.1

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/08941939.2017.1366603

    Web of Science

    Scopus

    PubMed

  49. Air test as a simple method of screening for Hirschsprung's disease

    Sumida W., Uchida H., Ono Y., Tanaka Y., Tainaka T., Shirota C., Yokota K., Oshima K., Chiba K.

    CLINICAL RADIOLOGY   Vol. 73 ( 12 ) page: 1041 - 1045   2018.12

     More details

    Language:Japanese   Publisher:Clinical Radiology  

    Aim: To present the technique and the diagnostic accuracy of the air test to diagnose Hirschsprung's disease (HD). Materials and methods: Children who attended hospital for chronic constipation (CC) between January 2012 and December 2016 for whom the air test was performed were enrolled. The test was conducted during contrast enema under fluoroscopic observation using 20–50 ml injections of air into the rectum through a 10 F Nelaton catheter. The demographics, results of the air test, and additional examinations, as well as the outcomes of subsequent treatments were analysed retrospectively. Results: The air test was conducted in 179 patients (median: 3 years, range: 0–14 years), and was positive in 150 and negative in 29 cases. Of the 29 patients with negative results, four were diagnosed with HD by rectal suction biopsy (RSB). Of the remaining 25 patients, RSB was conducted in seven and HD was excluded in all cases. In all 150 patients with positive air test results, CC was adequately controlled with conservative treatment. The sensitivity and specificity of the air test were 100% (4/4) and 85.7% (150/175), respectively. Conclusions: The air test can be used as a new non-invasive screening method for HD, performed simultaneously with contrast enema.

    DOI: 10.1016/j.crad.2018.08.008

    Web of Science

    Scopus

  50. Introduction of resection of intrahepatic bile duct stenosis-causing membrane or septum into laparoscopic choledochal cyst excision

    Tanaka Yujiro, Tainaka Takahisa, Sumida Wataru, Hinoki Akinari, Shirota Chiyoe, Murase Naruhiko, Oshima Kazuo, Shirotsuki Ryo, Chiba Kosuke, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 34 ( 10 ) page: 1087 - 1092   2018.10

     More details

    Language:Japanese   Publisher:Pediatric Surgery International  

    Purpose: We previously showed that meticulous probing and resection of the intrahepatic bile duct stenosis (IHBDS)-causing membrane or septum was effective in preventing hepatolithiasis after choledochal cyst excisions in open surgeries. Then, we introduced this maneuver into laparoscopic choledochal cyst excisions in 2014 and performed routine resections since then. The aim of this study was to show the feasibility of this method in laparoscopic surgery. Methods: We retrospectively reviewed the demographics and outcomes of patients who underwent laparoscopic choledochal cyst excisions at our hospital between January 2014 and December 2017. The patients who underwent surgical treatment for IHBDS-causing membrane or septum were compared with those who did not undergo the procedure. The outcomes of the patients with IHBDS were also compared between patients who were ≥ 3 years of age and those < 3 years at operation. Results: Seventeen of 35 patients underwent laparoscopic resection of IHBDS-causing membrane or septum. There were no complications related to the procedure although the operative time and intraoperative bleeding amount increased in the patients with IHBDS who were ≥ 3 years of age. Conclusions: Meticulous probing and excision of the IHBDS-causing membrane or septum is safe and feasible during laparoscopic choledochal cyst excision.

    DOI: 10.1007/s00383-018-4320-7

    Web of Science

    Scopus

    PubMed

  51. Single-stage laparoscopic transanal pull-through modified Swenson procedure without leaving a muscular cuff for short- and long-type Hirschsprung disease: a comparative study

    Yokota Kazuki, Uchida Hiroo, Tainaka Takahisa, Tanaka Yujiro, Shirota Chiyoe, Hinoki Akinari, Kato Takazumi, Sumida Wataru, Oshima Kazuo, Chiba Kosuke, Ishimaru Tetsuya, Kawashima Hiroshi

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 34 ( 10 ) page: 1105 - 1110   2018.10

     More details

    Language:Japanese   Publisher:Pediatric Surgery International  

    Purpose: The Soave procedure (SO) is performed most commonly for Hirschsprung disease. SO reduces the risk of injury to the pelvic structures; however, a residual aganglionic muscle cuff could interfere with bowel movement and lead to obstructive enterocolitis. The Swenson procedure is considered ideal in terms of peristalsis. Currently, laparoscopic surgery provides better visualization and facilitates precise dissection, possibly leading to feasible performance of the laparoscopic modified Swenson procedure (SW). We present our operative technique and the efficacy of the SW compared with that of SO. Methods: We retrospectively reviewed the records of 16 and 27 patients who underwent SW and SO, respectively, between 2012 and 2017. Results: Operative time, blood loss, length of stay, and frequency of bowel movements showed no significant difference between the two groups. In the SW group, temporary dysuria occurred in one patient, postoperative enterocolitis in two, wound infection in one, and severe perianal excoriation in four, whereas in the SO group, obstructive symptoms occurred in three patients, small-bowel obstruction in one, and severe perianal excoriation in three. The complications and outcomes were comparable between both groups. Conclusion: Laparoscopic SW was safe and feasible for the short-term follow-up outcomes.

    DOI: 10.1007/s00383-018-4318-1

    Web of Science

    Scopus

    PubMed

  52. Oral administration of eicosapentaenoic acid suppresses liver fibrosis in postoperative patients with biliary atresia

    Sumida Wataru, Uchida Hiroo, Tainaka Takahisa, Shirota Chiyoe, Hinoki Akinari, Kato Takazumi, Yokota Kazuki, Oshima Kazuo, Shirotuki Ryo, Chiba Kosuke, Tanaka Yujiro

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 34 ( 10 ) page: 1059 - 1063   2018.10

     More details

    Language:Japanese   Publisher:Pediatric Surgery International  

    Purpose: Biliary atresia (BA) is characterized by progressive inflammation of the biliary system. This inflammation persists and causes liver fibrosis, although jaundice disappears after Kasai portoenterostomy (KP). We aimed to confirm whether the oral administration of eicosapentaenoic acid (EPA) suppresses liver fibrosis in postoperative patients with BA. Methods: We reviewed patients who underwent laparoscopic KP (lapKP) between January 2014 and September 2017. From December 2016, 30 mg/kg/day of EPA was orally administered to patients who opted to take medicine (EPA group). Patients who did not receive EPA were assigned to the non-EPA group. Mac-2 binding protein sugar chain modified isomer (M2BPGi) and hyaluronic acid (HA) levels were compared between the two groups in patients showing disappearance of jaundice at 6 months after the first lapKP. Results: Seventeen patients in the non-EPA group and 11 in the EPA group were enrolled. At 6 months after the first lapKP, 10 patients in the non-EPA group and six in the EPA group were without jaundice. M2BPGi and HA levels were significantly lower in the EPA group. Conclusions: Liver fibrosis was suppressed in patients without jaundice 6 months after lapKP, who were administered EPA. We believe that periductular inflammation was alleviated by EPA supplementation.

    DOI: 10.1007/s00383-018-4313-6

    Web of Science

    Scopus

    PubMed

  53. Long-term outcomes and complications after laparoscopic-assisted anorectoplasty vs. posterior sagittal anorectoplasty for high- and intermediate-type anorectal malformation

    Tainaka Takahisa, Uchida Hiroo, Tanaka Yujiro, Hinoki Akinari, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Oshima Kazuo, Chiba Kosuke, Ishimaru Tetsuya, Kawashima Hiroshi

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 34 ( 10 ) page: 1111 - 1115   2018.10

     More details

    Language:Japanese   Publisher:Pediatric Surgery International  

    Purpose: Laparoscopic-assisted anorectoplasty (LAARP) is a minimally invasive procedure in which the levator ani muscle is left to potentially improve postoperative fecal continence. This study aimed to retrospectively evaluate postoperative complications and long-term outcomes of fecal continence after LAARP and compare them to those after posterior sagittal anorectoplasty (PSARP). Methods: Forty-five male patients with high and intermediate anorectal malformation (aged ≥ 4 years) who underwent LAARP or PSARP (LAARP 29, PSARP 16) from 1999 to 2013 were included. Postoperative complications and postoperative fecal continence were retrospectively evaluated and compared. Postoperative complications were also compared before and after introducing a urethroscope during fistula resection. Results: Complications after LAARP and PSARP were seen in 12 vs. 2 cases (p = 0.09) of mucosal prolapse and in 9 vs. 1 case (p = 0.07) of posterior urethral diverticulum (PUD), respectively. The incidence of PUD decreased after introduction of a urethroscopy from 40% in 8/20 cases to 11% in 1/9 cases. No significant difference was found in terms of fecal continence in both groups. Conclusion: Through our study, greater improvement of postoperative fecal continence after LAARP has not been shown. LAARP was at higher risk for mucosal prolapse and PUD. However, precise dissection of the urethral fistula could be performed after the introduction of urethroscopy.

    DOI: 10.1007/s00383-018-4323-4

    Web of Science

    Scopus

    PubMed

  54. 特集 小児外科における消化器内視鏡外科手術 胆道閉鎖症に対する腹腔鏡下肝門部空腸吻合術

    内田 広夫, 田中 裕次郎, 田井中 貴久, 城田 千代栄, 住田 亙, 村瀬 成彦

    手術   Vol. 72 ( 6 ) page: 861 - 870   2018.5

     More details

    Publisher:金原出版  

    DOI: 10.18888/op.0000000707

    CiNii Research

  55. Idiopathic Omental Torsion Relieved With Conservative Management

    Yokota Kazuki, Uchida Hiroo, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Hinoki Akinari, Sumida Wataru, Kato Takazumi, Oshima Kazuo, Chiba Kosuke

    Journal of the Japanese Society of Pediatric Surgeons   Vol. 54 ( 2 ) page: 302 - 306   2018

     More details

    Language:Japanese   Publisher:The Japanese Society of Pediatric Surgeons  

    <p>The patient was a 5-year-old boy who had no medical history. He was referred to us with suspected acute appendicitis and complaints of fever and lower abdominal pain. Although his abdominal pain was intense, rebound tenderness and muscular protection were negative. There were no symptoms of problems in the digestive tract such as vomiting or diarrhea. His blood examination revealed an increase in inflammatory reactions, as indicated by the increased white blood cell count and C-reactive protein levels. Computed tomography (CT) revealed wall thickening of the ascending colon; therefore, we started antibiotic administration after acute enterocolitis was diagnosed. After admission, we performed CT again and found a fatty and dense mass with a swirling structure inside the mass; therefore, we diagnosed the patient as having idiopathic omental torsion. Because the symptoms were relieved, conservative management was continued and the patient was discharged on the fourth day after hospitalization. Omental torsion is a rare condition, particularly seen in children; its classical treatment option is surgery. Although conservative management was successful in this case, there are few reports on it. There are many cases where surgery is performed after an initial diagnosis of acute appendicitis is made owing to the presence of similar symptoms. However, in recent years, because of advances in imaging diagnostic techniques such as CT, more patients are being accurately diagnosed. We believe that if patients are accurately diagnosed, surgery will always be required; however, conservative management is sometimes possible.</p>

    DOI: 10.11164/jjsps.54.2_302

    CiNii Research

  56. The efficacy of resection of intrahepatic bile duct stenosis-causing membrane or septum for preventing hepatolithiasis after choledochal cyst excision.

    Tanaka Y, Tainaka T, Sumida W, Shirota C, Hinoki A, Murase N, Oshima K, Shirotsuki R, Chiba K, Uchida H

    Journal of pediatric surgery   Vol. 52 ( 12 ) page: 1930 - 1933   2017.12

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jpedsurg.2017.08.056

    Web of Science

    Scopus

    PubMed

  57. Comparison of outcomes of thoracoscopic primary repair of gross type C esophageal atresia performed by qualified and non-qualified surgeons.

    Tanaka Y, Tainaka T, Sumida W, Shirota C, Murase N, Oshima K, Shirotsuki R, Chiba K, Uchida H

    Pediatric surgery international   Vol. 33 ( 10 ) page: 1081 - 1086   2017.10

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00383-017-4140-1

    Web of Science

    Scopus

    PubMed

  58. Review of redo-Kasai portoenterostomy for biliary atresia in the transition to the liver transplantation era.

    Sumida W, Uchida H, Tanaka Y, Tainaka T, Shirota C, Murase N, Oshima K, Shirotsuki R, Chiba K

    Nagoya journal of medical science   Vol. 79 ( 3 ) page: 415 - 420   2017.8

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.18999/nagjms.79.3.415

    Web of Science

    Scopus

    PubMed

  59. Two-Stage Thoracoscopic Repair of Long-Gap Esophageal Atresia Using Internal Traction Is Safe and Feasible.

    Tainaka T, Uchida H, Tanano A, Shirota C, Hinoki A, Murase N, Yokota K, Oshima K, Shirotsuki R, Chiba K, Amano H, Kawashima H, Tanaka Y

    Journal of laparoendoscopic & advanced surgical techniques. Part A   Vol. 27 ( 1 ) page: 71 - 75   2017.1

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/lap.2016.0207

    Web of Science

    Scopus

    PubMed

  60. Left thoracoscopic two-stage repair of tracheoesophageal fistula with a right aortic arch and a vascular ring.

    Oshima K, Uchida H, Tainaka T, Tanano A, Shirota C, Yokota K, Murase N, Shirotsuki R, Chiba K, Hinoki A

    Journal of minimal access surgery   Vol. 13 ( 1 ) page: 73 - 75   2017

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.4103/0972-9941.181771

    Web of Science

    Scopus

    PubMed

  61. Comparing surgical outcomes of complete thoracoscopic lobectomy for congenital cystic lung disease between neonatal and infantile patients.

    Tainaka T, Uchida H, Tanaka Y, Shirota C, Yokota K, Murase N, Oshima K, Shirotsuki R, Chiba K, Hinoki A

    Nagoya journal of medical science   Vol. 78 ( 4 ) page: 447-454   2016.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18999/nagjms.78.4.447

    PubMed

  62. Steroid pulse therapy prevents restenosis following balloon dilatation for esophageal stricture.

    Yokota K, Uchida H, Tanano A, Shirota C, Tainaka T, Hinoki A, Murase N, Oshima K, Shirotsuki R, Chiba K

    Pediatric surgery international   Vol. 32 ( 9 ) page: 875-9   2016.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00383-016-3939-5

    PubMed

  63. A new modification of laparoscopic percutaneous extraperitoneal closure procedure for repairing pediatric femoral hernias involving a special needle and a wire loop.

    Tainaka T, Uchida H, Ono Y, Tanano A, Shirota C, Yokota K, Murase N, Makita S, Shirotsuki R

    Nagoya journal of medical science   Vol. 77 ( 3 ) page: 531-5   2015.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

  64. A New Era of Laparoscopic Revision of Kasai Portoenterostomy for the Treatment of Biliary Atresia.

    Murase N, Uchida H, Ono Y, Tainaka T, Yokota K, Tanano A, Shirota C, Shirotsuki R

    BioMed research international   Vol. 2015   page: 173014   2015

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2015/173014

    PubMed

  65. Hepatolithiasis after hepatic portoenterostomy for biliary atresia.

    Tainaka T, Kaneko K, Seo T, Ono Y, Ogura Y, Wada H, Shirota C, Ando H

    Journal of pediatric surgery   Vol. 41 ( 4 ) page: 808-11   2006.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jpedsurg.2005.12.036

    PubMed

▼display all

Books 1

  1. Introduction to bIliary Atresia

    Masaki Nio(Chapter22 Hiroo Uchida, Chiyoe Shirota, Takahisa Tainaka)( Role: Contributor ,  chapter 22 : Operative Procedures:Laparoscopic Kasai Procedure)

    Springer  2021.4  ( ISBN:978-981-16-2159-8

     More details

    Total pages:350   Responsible for pages:147-156   Language:English

Presentations 17

  1. Efficacy of Double-Balloon Endoscopic Retrograde Cholangiography for Postoperative hepatolithiasis of Congenital Biliary Dilatation International coauthorship International conference

    2020.11.1 

  2. Endoscopic Navigation Surgery with Indocyanine Green Fluorescence in Pediatric Patients

    Shirota Chiyoe

    Pediatric Endosurgery Group

  3. Single-site laparoscopic surgery employing the Benz incision in the umbilicus for children. Single-site laparoscopic surgery employing the umbilical Benz incision for children.

    Shirota Chiyoe

    The European Association of Endoscopic Surgery

  4. Prognostic classification using indocyanine green fluorescence cholangiography in Kasai portoenterostomy for biliary atresia 

    Shirota Chiyoe

  5. 当院の腹腔鏡下胆道閉鎖症手術

    城田千代栄

    日本小児外科学会定期学術集会  2021.4.28 

  6. 卵巣滑脱ヘルニアに対する 腹腔鏡下鼠径ヘルニア手術

    城田千代栄

    日本小児外科学会定期学術集会  2021.4.28 

  7. 生体質感模擬臓器モデルを活用した 内視鏡手術トレーニングセミナーの開催

    城田千代栄

    第36回日本小児外科学会秋季シンポジウム  2019.11.1 

  8. A Case of Splenic Cord Capillary Hemangioma Treated with Partial Splenectomy International conference

    SHIROTA Chiyoe

    Japan Surgical Association 

     More details

    Event date: 2014

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

    A 12-year-old boy was referred to our hospital with suspected lymphoma when a splenic tumor was detected incidentally on a computed tomography (CT) scan following a fall. Magnetic resonance imaging (MRI) showed a round mass, 5 cm &times; 4.5 cm &times; 4.5 cm in size, in the splenic hilum that was hypointense on T1-weighted and hyperintense on T2-weighted imaging. On contrast-enhanced MRI, the mass was strongly enhanced almost homogeneously from the early phase, and the contrast effect was prolonged. A preoperative diagnosis of hemangioma or vascular tumor was made, and laparotomic partial splenectomy was performed. Doppler echocardiography was used to confirm the presence of blood flow between the tumor and healthy tissue, and peripheral branches of the splenic artery were sequentially clamped to identify the vessels feeding the tumor. Indigo carmine was injected via the tumor feeding vessels, and the incision line was determined so as to minimize hemorrhage during the partial resection. The remaining spleen was fixed to the greater omentum to prevent torsion. The patient's postoperative course was uneventful, and he was discharged from hospital five days postoperatively. The pathological diagnosis was cord capillary hemangioma.

  9. PO-181 脾部分切除を施行した脾毛細血管腫の1例(良性腫瘍,ポスターセッション,病気の子供達に笑顔 小児外科に夢そして革新を,第47回 日本小児外科学会学術集会) International conference

    城田 千代栄, 安藤 久實

    特定非営利活動法人 日本小児外科学会 

     More details

    Event date: 2010

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  10. Preoperative 5 Screening to Ensure Detection of Hemophilia International conference

    SHIROTA Chiyoe

    Japan Surgical Association 

     More details

    Event date: 2014

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

    Objective : Patients with hemophilia may show only a slight prolongation of the activated partial thromboplastin time (APTT) and the diagnosis may be overlooked during conventional preoperative testing. In the present study, an attempt was made to ensure identification of patients with latent hemophilia by setting the APTT cutoff value at 35.1 s (reference cutoff value at our hospital, 40.0 s) during testing prior to planned surgery.<BR>Method : The subjects comprised 445 patients who underwent testing of the coagulation profile prior to planned surgery between April 1, 2011 and November 30, 2013. A detailed medical history was obtained from the patients with APTT &ge;35.1 s ; those who gave no history of coagulation abnormalities were excluded. All the remaining patients were subjected to further testing (prothrombin time, repeat APTT, fibrinogen, antithrombin III, double-filtration plasmapheresis, D-dimer, and factor VIII, IX, and vW activity) to confirm the presence or absence of hemophilia.<BR>Results : The APTT was &ge;35.1 s in 40 patients (9.0%), of which 10 were excluded based on their negative medical history. The final diagnoses of the remaining 30 patients were as follows : no coagulation abnormalities, n=28 ; normalization during follow-up, n=1 ; hemophilia A, n=1. The patient with hemophilia A had no family history and the initial APTT value was within the reference cutoff value at 39.5 s.<BR>Conclusion : Efforts must be made to ensure preoperative identification of patients who may have undiagnosed latent hemophilia. Screening using an APTT cutoff value lower than the current reference value is required in order to ensure identification during preoperative testing.

  11. 1.Cystic partially differentiated nephroblastoma(CPDN)の1例(【I】病理検討,第51回東海小児がん研究会,研究会) International conference

    城田 千代栄, 石井 睦夫, 都築 豊徳

    がんの子供を守る会 

     More details

    Event date: 2009

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  12. RS-76 小児穿孔性虫垂炎の創感染における,創洗浄の有効性についての検討(要望演題4-4 消化器外科とSSI対策4,第63回日本消化器外科学会総会) International conference

    城田 千代栄

    一般社団法人日本消化器外科学会 

     More details

    Event date: 2008.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  13. 41. 診断について苦慮している性器出血の1例(第41回日本小児外科学会東海地方会) International conference

    城田 千代栄

    特定非営利活動法人 日本小児外科学会 

     More details

    Event date: 2008

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  14. P-2-471 ミルクアレルギーによりヒルシュスプルング病様症状を呈した1例(大腸・肛門 炎症性腸疾患3,一般演題(ポスター),第62回日本消化器外科学会定期学術総会) International conference

    城田 千代栄, 安藤 久實

    一般社団法人日本消化器外科学会 

     More details

    Event date: 2007.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  15. A CASE OF MESENTERIC LYMPHANGIOMA WITH SMALL BOWEL VOLVULUS International conference

    SHIROTA Chiyoe, HASEGAWA Hiroshi, SAKAMOTO Eiji, KOMATSU Shunichiro, KURUMIYA Yasuhiro, NORIMIZU Shinji

    Japan Surgical Association 

     More details

    Event date: 2007.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

    We report a case of a patient with mesenteric lymphangioma who presented with small-bowel volvulus. The patient was a 6-year-old boy who, from the age of 3 years, had presented with abdominal pain and vomiting but had not been diagnosed. He presented to our Unit with a 5-day history of intermittent abdominal pain and vomiting. CT of abdomen showed not only the mass but also a &ldquo;whirlpool sign&rdquo; suggestive of small-bowel volvulus. At surgery the bowel was found to be loosely twisted with mesenteric lymphangioma.

  16. 22. 診断・治療方針について苦慮している肝内嚢胞性病変の1例(困難症例,第40回日本小児外科学会東海地方会) International conference

    城田 千代栄

    特定非営利活動法人 日本小児外科学会 

     More details

    Event date: 2007

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  17. 19. 腸軸捻転で発症した腸間膜リンパ管腫の1例(第39回日本小児外科学会東海地方会) International conference

    城田 千代栄

    特定非営利活動法人 日本小児外科学会 

     More details

    Event date: 2006

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

▼display all

KAKENHI (Grants-in-Aid for Scientific Research) 12

  1. 腎芽腫患児の代謝物網羅解析によるバイオマーカーの探索と創薬への挑戦

    Grant number:21K07805  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    田中 裕次郎, 大澤 毅, 内田 広夫, 檜 顕成, 大島 一夫, 城田 千代栄, 田井中 貴久, 住田 亙, 横田 一樹

      More details

    Authorship:Coinvestigator(s) 

    腎芽腫は小児腎腫瘍の90%を占めるが、全体の約10%に予後不良群を認め、診断バイオマーカーが存在しない。最近メタボロミクス技術の発展により生体内の代謝情報を鋭敏且つ包括的に捉えることが可能となり、様々な癌種において新たなバイオマーカーや病態の解明が進んでいる。腎芽腫においても代謝変動の解明が病因解明や新規治療法の開発に寄与すると考えられるが、その代謝変動に着目した診断マーカーや創薬は前例がない。本研究では腎芽腫をターゲットに尿だけでなく、血液、がん組織を加えた腎芽腫50サンプルの代謝物変動を捉えるメタボローム解析を行い、疾患特異的なバイオマーカー探索とその病態解明に挑む。

  2. Development of fluorescent probes for diagnosis and treatment of pediatric surgical diseases

    Grant number:21K08640  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

      More details

    Authorship:Principal investigator 

    Grant amount:\4030000 ( Direct Cost: \3100000 、 Indirect Cost:\930000 )

  3. Development of a self-supporting ultrathin polymer film (nanosheet) for preventing postoperative suture failure and adhesion

    Grant number:20K08979  2020.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

      More details

    Authorship:Coinvestigator(s) 

  4. Development of tracheal stents made from new biodegradable Magnesium alloy

    Grant number:19K22654  2019.6 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

    Uchida Hiroo

      More details

    Authorship:Coinvestigator(s) 

    This study investigated in vitro and in vivo biocompatibility and degradation behavior of biodegradable tracheal stent composed of magnesium (Mg) alloy. Cytotoxicity test revealed in vitro biocompatibility. In the rat experiment, histopathological analysis revealed mild inflammatory reactions around the stent. In the rabbit experiment, there was no significant inflammatory response elevation, liver/renal function failure, or serum Mg concentration elevation in the blood test. However, its degradation rate was too fast; thus, the stent was coated with polylactic acid to reduce the degradation rate. In the rat experiment, Mg alloy stent coated by polylactic acid could keep the shape until six months postoperatively. Therefore, the proposed biodegradable Mg alloy tracheal stent coated with polylactic acid was considered to be a promising treatment device for pediatric tracheomalacia.

  5. The establish of off the job training for pediatric minimally invasive surgery and automated analysis system of operative technique

    Grant number:19H04225  2019.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

      More details

    Authorship:Coinvestigator(s) 

  6. Single cell transcriptome analysis for the intestinal immunity of neonates

    Grant number:18K19503  2018.6 - 2020.3

    Grant-in-Aid for Challenging Research (Exploratory)

    SAWA SHINICHIRO

      More details

    Authorship:Coinvestigator(s) 

    The first aim of this project was to understand composition and function of immune cells in human neonatal gut. We succeeded in setting up single cell transcriptome analysis about human intestinal cells. The second aim was to clarify etiology of neonatal necrotizing colitis (NEC). In NEC patients, intestinal inflammation and tissue necrosis is evident. Using single cell transcriptome analysis, we identified enhanced expression of chemokine receptors and adhesion molecules on T cells in NEC patients.

  7. Challenge to Optimize allocation of Pediatric Surgical Resources by using Remote Medical Platform

    Grant number:17H06280  2017.6 - 2020.3

    Grant-in-Aid for Challenging Research (Pioneering)

    Shirota Chiyoe

      More details

    Authorship:Principal investigator 

    Grant amount:\25870000 ( Direct Cost: \19900000 、 Indirect Cost:\5970000 )

    By developing an application and using one-to-many mobile telemedicine to securely link medical sites, we aimed to solve pediatric surgery medical infrastructure and at the same time spread and develop highly specialized telemedicine support. Many doctors can use the application to create a situation where dispersed cases in each region are aggregated in one place (one-to-many remote video conference, image sharing is possible on a smartphone). Can be shared in real time, participate in the consideration of treatment policy, and exchange opinions. We have started to provide highly specialized telemedicine support, which is available 24 hours a day, by securely linking medical fields with desired doctors and hospitals in Japan. The effective use of the system has made it possible to virtually consolidate a specialist with valuable cases.

  8. Establishment of an analytical workflow to elucidate the molecular biology of the pathogenesis of gastrointestinal diseases in neonates

    Grant number:17H04235  2017.4 - 2020.3

    Tanaka Yujiro

      More details

    Authorship:Coinvestigator(s) 

    Lymphocytes of 71 resected human bowels were examined using flow cytometry. Type 3 innate lymphoid cells (ILC3), which is known to regulate bowel immunity, was detected in all specimens. However, the percentage of ILC3 was not constant according to the condition of patients, e.g. gestational week and disease. Studying the bowel specimens of emergency laparotomy in human neonates, we also investigated the differences in gene expression between necrotizing enteritis and non-necrotic intestinal perforation. We studied the gene expression on a cell-by-cell basis of about 10,000 cells per each case, so we can assess what cells were specifically showing abnormal responses. To date, there have been no reports of gene expression analysis on a cell-by-cell basis. In necrotizing enteritis, T cells were dominant and pathways concerning inflammation, e.g. MYC targets, mTORC1 signaling, TNFA signaling were activated. In non-necrotic intestinal perforation, innate monocytic cells were the major.

  9. Development of a new biodegradable magnesium alloy for medical equipment

    Grant number:16H03197  2016.4 - 2019.3

    UCHIDA HIROO

      More details

    Authorship:Coinvestigator(s) 

    We focus on Mg alloy because it is biodegradable, and has excellent biocompatibility. Mg-based medical devices have already been clinically used as vascular stents and orthopaedic screws. However, Mg staples can easily fracture or degrade at the corners of the B-shape after stapling because of their vulnerability to stress corrosion. Another concern is the production of hydrogen gas caused by the rapid corrosion of Mg in physiological environments.
    To address the above challenges, we first redesigned the optimal staple shape to a more rounded form without acute bending points to reduce stress concentrations introduced by stapling and anastomosing. We also developed a novel Mg alloy with sufficiently high ductility to be finely processed to form the shape of a staple and stapled without fracturing. These two patents made us successful in developing Mg alloy staples, and we have confirmed them to be suitable for surgical stapling by rabbit intestinal anastomosis.

  10. a new wearable multi-lead electrocardiogram measuring system for super-ageing society

    Grant number:16K12957  2016.4 - 2019.3

    UCHIDA HIROO

      More details

    Authorship:Coinvestigator(s) 

    To develop a wearable multi-lead electrocardiogram (ECG) measuring system, we fabricated the electrode and wiring by using electrostatic flocking technology on a textile. By using this technology, it was possible to fabricate many electrodes and wiring, simultaneously. The fabricated wiring and electrodes had stretchability and wash resistance properties. To use dry electrodes, it is important to reduce the influence of motion artifacts (MAs). we conducted experiments with a human body to determine the relationship between the contact pressure and the MAs. under the pressures of 1000 Pa , 2000Pa and 4000Pa, the ECG signals under rest and deep breathing conditions were able to be measured without MAs. Finally, we fabricated the wearable ECG measuring system and succeeded in measuring 18-lead ECG signals. The measured ECG waveform is in good agreement with the ECG waveform measured by a commercial system.

  11. Development of a next generation photothermal therapy using a light-absorbing drug that selectively accumulates in lesions for pediatric cancer

    Grant number:16K15741  2016.4 - 2018.3

    TAINAKA Takahisa

      More details

    Authorship:Coinvestigator(s) 

    Even accompanied with infiltration / metastasis, pediatric solid cancer can be curable if the tumor can be completely removed by multidisciplinary treatment, but it is not easy in actual clinical practice. However, applicants have developed a new DDS (Drug Delivery System) type drug "ICG lactosome", which made it possible to carry out diagnosis and therapy simultaneously (Theranostics).ICG lactosome was proved to selectively accumulate in tumor. By fluorescence diagnosis and photothermal treatment using ICG lactosome, we succeeded in shrinking tumors of infiltrated neuroblastoma model mice.Photothermally treated tumor-bearing mice of which the tumor temperature was maintained at 43°C or more during the treatment showed almost completely tumor-extinction.

  12. Development of Retained Surgical Gauze Detection System before Closing Surgical Incisions.

    Grant number:15K15258  2015.4 - 2018.3

    Hinoki Akinari

      More details

    Authorship:Coinvestigator(s) 

    We found retained surgical gauze while creating several types of surgical gauze detection devices and surgical gauze for detection and detecting eddy current of metallic fiber included in the surgical gauze for detection. Actually, metallic fiber were included in surgical gauze and the change of eddy current was detected from the outside of the body before closing incisions, and the presence or absence of remnant gauze was verified. With respect to silver, the search for degradation kinetics in Both quantitative results of metallic element (silver) and pH change of the extract were very small, and it was judged that the influence of silver itself on the human body was extremely small. Considering biocompatibility, metallic resistance, actual detection distance, and decomposition dynamics in simulated environment of silver in the body, at present, it is necessary to set 4 or 16 circular sections (closed loop windings 3 to 7 times) of silver fibers.

▼display all

 

Teaching Experience (On-campus) 1

  1. 現代医療と自然科学

    2021

Teaching Experience (Off-campus) 1

  1. 小児外科講義

    National Defense Medical College)