Updated on 2024/09/20

写真a

 
BAGARINAO Epifanio Jr Tila
 
Organization
Graduate School of Medicine Associate professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Health Sciences
Title
Associate professor
External link

Degree 3

  1. Doctor of Science (Biophysical Engineering) ( 2000.3   Osaka University ) 

  2. Master of Science in Physics ( 1995.4   University of the Philippines ) 

  3. Bachelor of Science in Applied Physics ( 1993.4   University of the Philippines ) 

Research Interests 3

  1. brain science

  2. real-time fMRI

  3. neuroimaging

Research Areas 2

  1. Informatics / Life, health and medical informatics  / neuroinformatics

  2. Life Science / Basic brain sciences

Professional Memberships 3

  1. Organization for Human Brain Mapping

  2. Japan Neuroscience Society

  3. Society for Neuroscience

 

Papers 53

  1. Epileptic foci and networks in children with epilepsy after acute encephalopathy with biphasic seizures and late reduced diffusion Reviewed International journal

    Mitsumatsu, T; Ito, Y; Maki, Y; Yamamoto, H; Sawamura, F; Ishizaki, T; Maesawa, S; Bagarinao, E; Nakata, T; Kidokoro, H; Saito, R; Natsume, J

    BRAIN & DEVELOPMENT   Vol. 46 ( 9 ) page: 302 - 307   2024.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Brain and Development  

    Background: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) develops along with status epilepticus and widespread subcortical white matter edema. We aimed to evaluate the epileptic foci and networks in two patients with epilepsy after AESD using simultaneous electroencephalography and functional magnetic resonance imaging (EEG-fMRI). Methods: Statistically significant blood oxygen level-dependent (BOLD) responses related to interictal epileptiform discharges (IEDs) were analyzed using an event-related design of hemodynamic response functions with multiple peaks. Results: Patient 1 developed focal seizures at age 10 years, one year after AESD onset. Positive BOLD changes were observed in the bilateral frontotemporal lobes, left parietal lobe, and left insula. BOLD changes were also observed in the subcortical structures. Patient 2 developed epileptic spasms at age two years, one month after AESD onset. Following total corpus callosotomy (CC) at age three years, the epileptic spasms resolved, and neurodevelopmental improvement was observed. Before CC, positive BOLD changes were observed bilaterally in the frontotemporal lobes. BOLD changes were also observed in the subcortical structures. After CC, the positive BOLD changes were localized in the temporal lobe ipsilateral to the IEDs, and the negative BOLD changes were mainly in the cortex and subcortical structures of the hemisphere ipsilateral to IEDs. Conclusion: EEG-fMRI revealed multiple epileptic foci and extensive epileptic networks, including subcortical structures in two cases with post-AESD epilepsy. CC may be effective in disconnecting the bilaterally synchronous epileptic networks of epileptic spasms after AESD, and pre-and post-operative changes in EEG-fMRI may reflect improvements in epileptic symptoms.

    DOI: 10.1016/j.braindev.2024.07.003

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  2. Longitudinal brain changes in Parkinson's disease with severe olfactory deficit. Reviewed International coauthorship International journal

    Kawabata K, Bagarinao E, Seppi K, Poewe W

    Parkinsonism & related disorders   Vol. 122   page: 106072   2024.2

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    DOI: 10.1016/j.parkreldis.2024.106072

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  3. Cerebellar and thalamic connector hubs facilitate the involvement of visual and cognitive networks in essential tremor. Reviewed International journal

    Bagarinao E, Maesawa S, Kato S, Mutoh M, Ito Y, Ishizaki T, Tanei T, Tsuboi T, Suzuki M, Watanabe H, Hoshiyama M, Isoda H, Katsuno M, Sobue G, Saito R

    Parkinsonism & related disorders   Vol. 121   page: 106034   2024.2

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.parkreldis.2024.106034

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  4. Cognitive dysfunction in de novo Parkinson disease: Remitting vs. progressive cognitive impairment. Reviewed International coauthorship

    Kawabata K, Djamshidian A, Bagarinao E, Weintraub D, Seppi K, Poewe W

    Parkinsonism & related disorders   Vol. 120   page: 105984   2023.12

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    DOI: 10.1016/j.parkreldis.2023.105984

    DOI: 10.1016/j.parkreldis.2023.105984

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  5. Pattern of THK 5351 retention in normal aging involves core regions of resting state networks associated with higher cognitive function

    Yoshida, Y; Yokoi, T; Hara, K; Watanabe, H; Yamaguchi, H; Bagarinao, E; Masuda, M; Kato, T; Ogura, A; Ohdake, R; Kawabata, K; Katsuno, M; Kato, K; Naganawa, S; Okamura, N; Yanai, K; Sobue, G

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 85 ( 4 ) page: 758 - 771   2023.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18999/nagjms.85.4.758

    DOI: 10.18999/nagjms.85.4.758

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  6. Involvement of the Thalamus, Hippocampus, and Brainstem in Hypsarrhythmia of West Syndrome: Simultaneous Recordings of Electroencephalography and fMRI Study Reviewed International journal

    Maki Y., Natsume J., Ito Y., Okai Y., Bagarinao E., Yamamoto H., Ogaya S., Takeuchi T., Fukasawa T., Sawamura F., Mitsumatsu T., Maesawa S., Saito R., Takahashi Y., Kidokoro H.

    AMERICAN JOURNAL OF NEURORADIOLOGY   Vol. 43 ( 10 ) page: 1502 - 1507   2022.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3174/ajnr.A7646

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  7. Connectivity impairment of cerebellar and sensorimotor connector hubs in Parkinson's disease Reviewed International journal

    Bagarinao Epifanio, Kawabata Kazuya, Watanabe Hirohisa, Hara Kazuhiro, Ohdake Reiko, Ogura Aya, Masuda Michihito, Kato Toshiyasu, Maesawa Satoshi, Katsuno Masahisa, Sobue Gen

    BRAIN COMMUNICATIONS   Vol. 4 ( 5 ) page: fcac214   2022.8

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/braincomms/fcac214

    DOI: 10.1093/braincomms/fcac214

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  8. Functional connector hubs in the cerebellum Reviewed International journal

    Kawabata K, Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Ohdake R, Masuda M, Ogura A, Kato T, Koyama S, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G

    NeuroImage   Vol. 257   page: 119263   2022.8

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    DOI: 10.1016/j.neuroimage.2022.119263

    DOI: 10.1016/j.neuroimage.2022.119263

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  9. Reproducibility of functional connectivity metrics estimated from resting-state functional MRI with differences in days, coils, and global signal regression Reviewed

    Kato Sanae, Bagarinao Epifanio, Isoda Haruo, Koyama Shuji, Watanabe Hirohisa, Maesawa Satoshi, Hara Kazuhiro, Katsuno Masahisa, Naganawa Shinji, Ozaki Norio, Sobue Gen

    RADIOLOGICAL PHYSICS AND TECHNOLOGY   Vol. 15   page: 298 - 310   2022.8

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12194-022-00670-6

    DOI: 10.1007/s12194-022-00670-6

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  10. Involvement of cerebellar and subcortical connector hubs in schizophrenia Reviewed International journal

    Yamamoto Maeri, Bagarinao Epifanio, Shimamoto Masanori, Iidaka Tetsuya, Ozaki Norio

    NEUROIMAGE-CLINICAL   Vol. 35   page: 103140   2022.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.nicl.2022.103140

    DOI: 10.1016/j.nicl.2022.103140

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  11. Magnetic resonance-guided focused ultrasound thalamotomy restored distinctive resting-state networks in patients with essential tremor. Reviewed International journal

    Kato S, Maesawa S, Bagarinao E, Nakatsubo D, Tsugawa T, Mizuno S, Kawabata K, Tsuboi T, Suzuki M, Shibata M, Takai S, Ishizaki T, Torii J, Mutoh M, Saito R, Wakabayashi T, Katsuno M, Ozaki N, Watanabe H, Sobue G

    Journal of neurosurgery   Vol. 138 ( 2 ) page: 306 - 317   2022.7

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    DOI: 10.3171/2022.5.JNS22411

    DOI: 10.3171/2022.5.JNS22411

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  12. Reserve and Maintenance in the Aging Brain: A Longitudinal Study of Healthy Older Adults Reviewed International journal

    Bagarinao Epifanio, Watanabe Hirohisa, Maesawa Satoshi, Kawabata Kazuya, Hara Kazuhiro, Ohdake Reiko, Ogura Aya, Mori Daisuke, Yoneyama Noritaka, Imai Kazunori, Yokoi Takamasa, Kato Toshiyasu, Koyama Shuji, Katsuno Masahisa, Wakabayashi Toshihiko, Kuzuya Masafumi, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Ozaki Norio, Sobue Gen

    ENEURO   Vol. 9 ( 1 )   2022.1

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1523/ENEURO.0455-21.2022

    DOI: 10.1523/ENEURO.0455-21.2022

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  13. Multitier Network Analysis Using Resting-state Functional MRI for Epilepsy Surgery Reviewed International journal

    Maesawa Satoshi, Bagarinao Epifanio, Nakatsubo Daisuke, Ishizaki Tomotaka, Takai Sou, Torii Jun, Kato Sachiko, Shibata Masashi, Wakabayashi Toshihiko, Saito Ryuta

    NEUROLOGIA MEDICO-CHIRURGICA   Vol. 62 ( 1 ) page: 45 - 55   2022.1

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    DOI: 10.2176/nmc.oa.2021-0173

    DOI: 10.2176/nmc.oa.2021-0173

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  14. Resting State Networks Related to the Maintenance of Good Cognitive Performance During Healthy Aging Reviewed International journal

    Maesawa Satoshi, Mizuno Satomi, Bagarinao Epifanio, Watanabe Hirohisa, Kawabata Kazuya, Hara Kazuhiro, Ohdake Reiko, Ogura Aya, Mori Daisuke, Nakatsubo Daisuke, Isoda Haruo, Hoshiyama Minoru, Katsuno Masahisa, Saito Ryuta, Ozaki Norio, Sobue Gen

    FRONTIERS IN HUMAN NEUROSCIENCE   Vol. 15   page: 753836   2021.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fnhum.2021.753836

    DOI: 10.3389/fnhum.2021.753836

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  15. Bridging large-scale cortical networks: Integrative and function-specific hubs in the thalamus. Reviewed International journal

    Kawabata K, Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Ohdake R, Masuda M, Ogura A, Kato T, Koyama S, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G

    iScience   Vol. 24 ( 10 ) page: 103106   2021.10

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    DOI: 10.1016/j.isci.2021.103106

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  16. Fiber-specific white matter analysis reflects upper motor neuron impairment in amyotrophic lateral sclerosis. Reviewed International journal

    Ogura A, Kawabata K, Watanabe H, Choy SW, Bagarinao E, Kato T, Imai K, Masuda M, Ohdake R, Hara K, Nakamura R, Atsuta N, Nakamura T, Katsuno M, Sobue G

    European journal of neurology   Vol. 29 ( 2 ) page: 432 - 440   2021.10

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    DOI: 10.1111/ene.15136

    DOI: 10.1111/ene.15136

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  17. Involvement of brain structures in childhood epilepsy with centrotemporal spikes. Reviewed

    Ito Y, Maki Y, Okai Y, Kidokoro H, Bagarinao E, Takeuchi T, Ohno A, Nakata T, Ishihara N, Okumura A, Yamamoto H, Maesawa S, Natsume J

    Pediatrics international : official journal of the Japan Pediatric Society   Vol. 64 ( 1 ) page: e15001   2021.9

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    DOI: 10.1111/ped.15001

    DOI: 10.1111/ped.15001

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  18. Clinicoradiological features in amyotrophic lateral sclerosis patients with olfactory dysfunction. Reviewed International journal

    Masuda M, Watanabe H, Ogura A, Ohdake R, Kato T, Kawabata K, Hara K, Nakamura R, Atsuta N, Epifanio B, Katsuno M, Sobue G

    Amyotrophic lateral sclerosis & frontotemporal degeneration   Vol. 22 ( 3-4 ) page: 260 - 266   2021.5

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    DOI: 10.1080/21678421.2020.1859544

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  19. Characteristics of Neural Network Changes in Normal Aging and Early Dementia. Reviewed International journal

    Watanabe H, Bagarinao E, Maesawa S, Hara K, Kawabata K, Ogura A, Ohdake R, Shima S, Mizutani Y, Ueda A, Ito M, Katsuno M, Sobue G

    Frontiers in aging neuroscience   Vol. 13   page: 747359   2021

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Frontiers in Aging Neuroscience  

    To understand the mechanisms underlying preserved and impaired cognitive function in healthy aging and dementia, respectively, the spatial relationships of brain networks and mechanisms of their resilience should be understood. The hub regions of the brain, such as the multisensory integration and default mode networks, are critical for within- and between-network communication, remain well-preserved during aging, and play an essential role in compensatory processes. On the other hand, these brain hubs are the preferred sites for lesions in neurodegenerative dementias, such as Alzheimer’s disease. Disrupted primary information processing networks, such as the auditory, visual, and sensorimotor networks, may lead to overactivity of the multisensory integration networks and accumulation of pathological proteins that cause dementia. At the cellular level, the brain hub regions contain many synapses and require a large amount of energy. These regions are rich in ATP-related gene expression and had high glucose metabolism as demonstrated on positron emission tomography (PET). Importantly, the number and function of mitochondria, which are the center of ATP production, decline by about 8% every 10 years. Dementia patients often have dysfunction of the ubiquitin-proteasome and autophagy-lysosome systems, which require large amounts of ATP. If there is low energy supply but the demand is high, the risk of disease can be high. Imbalance between energy supply and demand may cause accumulation of pathological proteins and play an important role in the development of dementia. This energy imbalance may explain why brain hub regions are vulnerable to damage in different dementias. Here, we review (1) the characteristics of gray matter network, white matter network, and resting state functional network changes related to resilience in healthy aging, (2) the mode of resting state functional network disruption in neurodegenerative dementia, and (3) the cellular mechanisms associated with the disruption.

    DOI: 10.3389/fnagi.2021.747359

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  20. Support vector machine-based classification of schizophrenia patients and healthy controls using structural magnetic resonance imaging from two independent sites Reviewed

    Yamamoto Maeri, Bagarinao Epifanio, Kushima Itaru, Takahashi Tsutomu, Sasabayashi Daiki, Inada Toshiya, Suzuki Michio, Iidaka Tetsuya, Ozaki Norio

    PLOS ONE   Vol. 15 ( 11 ) page: e0239615   2020.11

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    DOI: 10.1371/journal.pone.0239615

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  21. Identifying the brain's connector hubs at the voxel level using functional connectivity overlap ratio Reviewed

    Bagarinao Epifanio, Watanabe Hirohisa, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Kawabata Kazuya, Ohdake Reiko, Masuda Michihito, Ogura Aya, Kato Toshiyasu, Koyama Shuji, Katsuno Masahisa, Wakabayashi Toshihiko, Kuzuya Masafumi, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Ozaki Norio, Sobue Gen

    NEUROIMAGE   Vol. 222   page: 117241   2020.11

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neuroimage.2020.117241

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  22. Cerebello-basal ganglia connectivity fingerprints related to motor/cognitive performance in Parkinson's disease Reviewed

    Kawabata Kazuya, Watanabe Hirohisa, Bagarinao Epifanio, Ohdake Reiko, Hara Kazuhiro, Ogura Aya, Masuda Michihito, Kato Toshiyasu, Tsuboi Takashi, Maesawa Satoshi, Katsuno Masahisa, Sobue Gen

    PARKINSONISM & RELATED DISORDERS   Vol. 80   page: 21 - 27   2020.11

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    DOI: 10.1016/j.parkreldis.2020.09.005

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  23. The neural network basis of altered decision-making in patients with amyotrophic lateral sclerosis Reviewed

    Imai Kazunori, Masuda Michihito, Watanabe Hirohisa, Ogura Aya, Ohdake Reiko, Tanaka Yasuhiro, Kato Toshiyasu, Kawabata Kazuya, Riku Yuichi, Hara Kazuhiro, Nakamura Ryoichi, Atsuta Naoki, Bagarinao Epifanio, Katahira Kentaro, Ohira Hideki, Katsuno Masahisa, Sobue Gen

    ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY   Vol. 7 ( 11 ) page: 2115 - 2126   2020.11

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    DOI: 10.1002/acn3.51185

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  24. Aging Impacts the Overall Connectivity Strength of Regions Critical for Information Transfer Among Brain Networks Reviewed

    Bagarinao Epifanio, Watanabe Hirohisa, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Kawabata Kazuya, Yoneyama Noritaka, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Taoka Toshiaki, Koyama Shuji, Tanabe Hiroki C., Katsuno Masahisa, Wakabayashi Toshihiko, Kuzuya Masafumi, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Ozaki Norio, Sobue Gen

    FRONTIERS IN AGING NEUROSCIENCE   Vol. 12   page: 592469   2020.10

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    DOI: 10.3389/fnagi.2020.592469

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  25. Effects of Head Motion on the Evaluation of Age-related Brain Network Changes Using Resting State Functional MRI. Reviewed

    Kato S, Bagarinao E, Isoda H, Koyama S, Watanabe H, Maesawa S, Mori D, Hara K, Katsuno M, Hoshiyama M, Naganawa S, Ozaki N, Sobue G

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2020.10

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    DOI: 10.2463/mrms.mp.2020-0081

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  26. Improving Real-Time Brain State Classification of Motor Imagery Tasks During Neurofeedback Training Reviewed

    Bagarinao Epifanio, Yoshida Akihiro, Terabe Kazunori, Kato Shohei, Nakai Toshiharu

    FRONTIERS IN NEUROSCIENCE   Vol. 14   page: 623   2020.6

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    DOI: 10.3389/fnins.2020.00623

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  27. Changes in white matter fiber density and morphology across the adult lifespan: A cross-sectional fixel-based analysis Reviewed International coauthorship

    Choy Shao Wei, Bagarinao Epifanio, Watanabe Hirohisa, Ho Eric Tatt Wei, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Kawabata Kazuya, Yoneyama Noritaka, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Taoka Toshiaki, Koyama Shuji, Tanabe Hiroki C., Katsuno Masahisa, Wakabayashi Toshihiko, Kuzuya Masafumi, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Ozaki Norio, Sobue Gen

    HUMAN BRAIN MAPPING   Vol. 41   page: 3198 - 3211   2020.4

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    DOI: 10.1002/hbm.25008

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  28. Subsecond EEG-fMRI analysis for presurgical evaluation in focal epilepsy. Reviewed

    Ito Y, Maesawa S, Bagarinao E, Okai Y, Nakatsubo D, Yamamoto H, Kidokoro H, Usui N, Natsume J, Hoshiyama M, Wakabayashi T, Sobue G, Ozaki N

    Journal of neurosurgery     page: 1-10   2020.3

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    DOI: 10.3171/2020.1.JNS192567

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  29. Visuoperceptual disturbances in Parkinson's disease Reviewed

    Kawabata Kazuya, Ohdake Reiko, Watanabe Hirohisa, Bagarinao Epifanio, Hara Kazuhiro, Ogura Aya, Masuda Michihito, Kato Toshiyasu, Yokoi Takamasa, Katsuno Masahisa, Sobue Gen

    Clinical Parkinsonism & Related Disorders   Vol. 3   page: 100036   2020.1

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    DOI: 10.1016/j.prdoa.2020.100036

  30. Novel Characterization Of Thermal Temporal Summation Response By Analysis Of Continuous Pain Vs Time Curves And Exploratory Modeling Reviewed International coauthorship

    Kong Jiang-Ti, Bagarinao Epifanio, Olshen Richard A., Mackey Sean

    JOURNAL OF PAIN RESEARCH   Vol. 12   page: 3231-3244   2019.12

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    DOI: 10.2147/JPR.S212137

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  31. Semantic deficits in ALS related to right lingual/fusiform gyrus network involvement Reviewed

    Ogura Aya, Watanabe Hirohisa, Kawabata Kazuya, Ohdake Reiko, Tanaka Yasuhiro, Masuda Michihito, Kato Toshiyasu, Imai Kazunori, Yokoi Takamasa, Hara Kazuhiro, Bagarinao Epifanio, Riku Yuichi, Nakamura Ryoichi, Kawai Yoshinari, Nakatochi Masahiro, Atsuta Naoki, Katsuno Masahisa, Sobue Gen

    EBIOMEDICINE   Vol. 47   page: 506-517   2019.9

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    DOI: 10.1016/j.ebiom.2019.08.022

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  32. Reorganization of brain networks and its association with general cognitive performance over the adult lifespan Reviewed

    Bagarinao Epifanio, Watanabe Hirohisa, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Kawabata Kazuya, Yoneyama Noritaka, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Taoka Toshiaki, Koyama Shuji, Tanabe Hiroki C., Katsuno Masahisa, Wakabayashi Toshihiko, Kuzuya Masafumi, Ozaki Norio, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Sobue Gen

    SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page: 11352   2019.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-019-47922-x

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  33. Alterations in Cognition-Related Cerebello-Cerebral Networks in Multiple System Atrophy Reviewed

    Kawabata Kazuya, Hara Kazuhiro, Watanabe Hirohisa, Bagarinao Epifanio, Ogura Aya, Masuda Michihito, Yokoi Takamasa, Kato Toshiyasu, Ohdake Reiko, Ito Mizuki, Katsuno Masahisa, Sobue Gen

    CEREBELLUM   Vol. 18 ( 4 ) page: 770-780   2019.8

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    DOI: 10.1007/s12311-019-01031-7

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  34. Tau Accumulation and Network Breakdown in Alzheimer's Disease.

    Watanabe H, Bagarinao E, Yokoi T, Yamaguchi H, Ishigaki S, Mausuda M, Katsuno M, Sobue G

    Advances in experimental medicine and biology   Vol. 1184   page: 231 - 240   2019

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    DOI: 10.1007/978-981-32-9358-8_19

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  35. Corpus callosal involvement is correlated with cognitive impairment in multiple system atrophy Reviewed

    Hara Kazuhiro, Watanabe Hirohisa, Bagarinao Epifanio, Kawabata Kazuya, Yoneyama Noritaka, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Tsuboi Takashi, Ito Mizuki, Atsuta Naoki, Niwa Hisayoshi, Taoka Toshiaki, Maesawa Satoshi, Naganawa Shinji, Katsuno Masahisa, Sobue Gen

    JOURNAL OF NEUROLOGY   Vol. 265 ( 9 ) page: 2079 - 2087   2018.9

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    DOI: 10.1007/s00415-018-8923-7

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  36. Improved Volitional Recall of Motor-Imagery-Related Brain Activation Patterns Using Real-Time Functional MRI-Based Neurofeedback Reviewed

    Bagarinao Epifanio, Yoshida Akihiro, Ueno Mika, Terabe Kazunori, Kato Shohei, Isoda Haruo, Nakai Toshiharu

    FRONTIERS IN HUMAN NEUROSCIENCE   Vol. 12   page: 158   2018.4

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    DOI: 10.3389/fnhum.2018.00158

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  37. Effects of Gradient Coil Noise and Gradient Coil Replacement on the Reproducibility of Resting State Networks Reviewed

    Bagarinao Epifanio, Tsuzuki Erina, Yoshida Yukina, Ozawa Yohei, Kuzuya Maki, Otani Takashi, Koyama Shuji, Isoda Haruo, Watanabe Hirohisa, Maesawa Satoshi, Naganawa Shinji, Sobue Gen

    FRONTIERS IN HUMAN NEUROSCIENCE   Vol. 12   page: 148   2018.4

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    DOI: 10.3389/fnhum.2018.00148

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  38. An unbiased data-driven age-related structural brain parcellation for the identification of intrinsic brain volume changes over the adult lifespan Reviewed

    Bagarinao Epifanio, Watanabe Hirohisa, Maesawa Satoshi, Mori Daisuke, Hara Kazuhiro, Kawabata Kazuya, Yoneyama Noritaka, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Wakabayashi Toshihiko, Kuzuya Masafumi, Ozaki Norio, Hoshiyama Minoru, Isoda Haruo, Naganawa Shinji, Sobue Gen

    NEUROIMAGE   Vol. 169   page: 134 - 144   2018.4

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    DOI: 10.1016/j.neuroimage.2017.12.014

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  39. Default Mode Network Changes in Moyamoya Disease Before and After Bypass Surgery: Preliminary Report

    Sakamoto Yusuke, Okamoto Sho, Maesawa Satoshi, Bagarinao Epifanio, Araki Yoshio, Izumi Takashi, Watanabe Hirohisa, Sobue Gen, Wakabayashi Toshihiko

    WORLD NEUROSURGERY   Vol. 112   page: e652 - e661   2018.4

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    DOI: 10.1016/j.wneu.2018.01.117

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  40. Distinct manifestation of cognitive deficits associate with different resting-state network disruptions in non-demented patients with Parkinson's disease

    Kawabata Kazuya, Watanabe Hirohisa, Hara Kazuhiro, Bagarinao Epifanio, Yoneyama Noritaka, Ogura Aya, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ohdake Reiko, Tanaka Yasuhiro, Tsuboi Takashi, Nakamura Tomohiko, Hirayama Masaaki, Ito Mizuki, Atsuta Naoki, Maesawa Satoshi, Naganawa Shinji, Katsuno Masahisa, Sobue Gen

    JOURNAL OF NEUROLOGY   Vol. 265 ( 3 ) page: 688-700   2018.3

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    DOI: 10.1007/s00415-018-8755-5

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  41. Detecting sub-second changes in brain activation patterns during interictal epileptic spike using simultaneous EEG-fMRI

    Bagarinao Epifanio, Maesawa Satoshi, Ito Yuji, Usui Naotaka, Natsume Jun, Watanabe Hirohisa, Hoshiyama Minoru, Wakabayashi Toshihiko, Sobue Gen, Naganawa Shinji, Isoda Haruo

    CLINICAL NEUROPHYSIOLOGY   Vol. 129 ( 2 ) page: 377 - 389   2018.2

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    DOI: 10.1016/j.clinph.2017.11.018

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  42. [(1)Detection of Epileptic Focus Using Electroencephalography-Functional Magnetic Resonance Imaging(EEG-fMRI)].

    Maesawa S, Bagarinao E, Nakatsubo D, Wakabayashi T

    No shinkei geka. Neurological surgery   Vol. 46 ( 1 ) page: 67 - 79   2018.1

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  43. Severe hyposmia and aberrant functional connectivity in cognitively normal Parkinson's disease

    Yoneyama Noritaka, Watanabe Hirohisa, Kawabata Kazuya, Bagarinao Epifanio, Hara Kazuhiro, Tsuboi Takashi, Tanaka Yasuhiro, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Hattori Tatsuya, Ito Mizuki, Atsuta Naoki, Nakamura Tomohiko, Hirayama Masaaki, Maesawa Satoshi, Katsuno Masahisa, Sobue Gen

    PLOS ONE   Vol. 13 ( 1 ) page: e0190072   2018

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    DOI: 10.1371/journal.pone.0190072

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  44. Involvement of the Precuneus/Posterior Cingulate Cortex Is Significant for the Development of Alzheimer's Disease: A PET (THK5351, PiB) and Resting fMRI Study

    Yokoi Takamasa, Watanabe Hirohisa, Yamaguchi Hiroshi, Bagarinao Epifanio, Masuda Michihito, Imai Kazunori, Ogura Aya, Ohdake Reiko, Kawabata Kazuya, Hara Kazuhiro, Riku Yuichi, Ishigaki Shinsuke, Katsuno Masahisa, Miyao Shinichi, Kato Katsuhiko, Naganawa Shinji, Harada Ryuichi, Okamura Nobuyuki, Yenai Kazuhiko, Yoshida Mari, Sobue Gen

    FRONTIERS IN AGING NEUROSCIENCE   Vol. 10 ( OCT ) page: 304   2018

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    DOI: 10.3389/fnagi.2018.00304

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  45. Structural MRI correlates of amyotrophic lateral sclerosis progression

    Senda Joe, Atsuta Naoki, Watanabe Hirohisa, Bagarinao Epifanio, Imai Kazunori, Yokoi Daichi, Riku Yuichi, Masuda Michihito, Nakamura Ryoichi, Watanabe Hazuki, Ito Mizuki, Katsuno Masahisa, Naganawa Shinji, Sobue Gen

    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY   Vol. 88 ( 11 ) page: 901 - 907   2017.11

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    DOI: 10.1136/jnnp-2016-314337

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  46. Active brain changes after initiating fingolimod therapy in multiple sclerosis patients using individual voxel-based analyses for diffusion tensor imaging.

    Senda J, Watanabe H, Endo K, Yasui K, Hawsegawa Y, Yoneyama N, Tsuboi T, Hara K, Ito M, Atsuta N, Epifanio B Jr, Katsuno M, Naganawa S, Sobue G

    Nagoya journal of medical science   Vol. 78 ( 4 ) page: 455 - 463   2016.12

  47. Involvement of the caudate nucleus head and its networks in sporadic amyotrophic lateral sclerosis-frontotemporal dementia continuum.

    Masuda M, Senda J, Watanabe H, Epifanio B, Tanaka Y, Imai K, Riku Y, Li Y, Nakamura R, Ito M, Ishigaki S, Atsuta N, Koike H, Katsuno M, Hattori N, Naganawa S, Sobue G

    Amyotrophic lateral sclerosis & frontotemporal degeneration   Vol. 17 ( 7-8 ) page: 571 - 579   2016.10

  48. Effects of salience-network-node neurofeedback training on affective biases in major depressive disorder.

    Hamilton JP, Glover GH, Bagarinao E, Chang C, Mackey S, Sacchet MD, Gotlib IH

    Psychiatry research. Neuroimaging   Vol. 249   page: 91 - 6   2016.3

  49. Use of Network Analysis to Establish Neurosurgical Parameters in Gliomas and Epilepsy

    Maesawa Satoshi, Bagarinao Epifanio, Fujii Masazumi, Futamura Miyako, Wakabayashi Toshihiko

    NEUROLOGIA MEDICO-CHIRURGICA   Vol. 56 ( 4 ) page: 158 - 169   2016

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    Publisher:Neurologia Medico-Chirurgica  

    DOI: 10.2176/nmc.ra.2015-0302

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  50. The posterior medial cortex in urologic chronic pelvic pain syndrome: detachment from default mode network-a resting-state study from the MAPP Research Network.

    Martucci KT, Shirer WR, Bagarinao E, Johnson KA, Farmer MA, Labus JS, Apkarian AV, Deutsch G, Harris RE, Mayer EA, Clauw DJ, Greicius MD, Mackey SC

    Pain   Vol. 156 ( 9 ) page: 1755 - 1764   2015.9

  51. Evaluation of Resting State Networks in Patients with Gliomas: Connectivity Changes in the Unaffected Side and Its Relation to Cognitive Function Reviewed

    Maesawa Satoshi, Bagarinao Epifanio, Fujii Masazumi, Futamura Miyako, Motomura Kazuya, Watanabe Hirohisa, Mori Daisuke, Sobue Gen, Wakabayashi Toshihiko

    PLOS ONE   Vol. 10 ( 2 ) page: e0118072   2015.2

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    DOI: 10.1371/journal.pone.0118072

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  52. Preliminary structural MRI based brain classification of chronic pelvic pain: A MAPP network study Reviewed International coauthorship

    Bagarinao Epifanio, Johnson Kevin A., Martucci Katherine T., Ichesco Eric, Farmer Melissa A., Labus Jennifer, Ness Timothy J., Harris Richard, Deutsch Georg, Apkarian A. Vania, Mayer Emeran A., Clauw Daniel J., Mackey Sean

    PAIN   Vol. 155 ( 12 ) page: 2502 - 2509   2014.12

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    DOI: 10.1016/j.pain.2014.09.002

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  53. Regional gray matter density differences predict classification of chronic pelvic pain and fibromyalgia: findings from the MAPP Research Network Reviewed International coauthorship

    Martucci K., Bagarinao E., Johnson K., Ichesco E., Farmer M., Labus J., Ness T., Harris R., Deutsch G., Apkarian A., Mayer E., Clauw D., Mackey S.

    JOURNAL OF PAIN   Vol. 15 ( 4 ) page: S55-S55   2014.4

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Presentations 26

  1. Advancing real-time functional MRI for neurosurgical applications: Precision functional network mapping of the human brain International conference

    Epifanio Bagarinao

    BrainConnects 2023  2023.8.19 

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    Event date: 2023.8

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Ho Chi Minh   Country:Viet Nam  

    Other Link: https://www.brainconnects2023.com/

  2. Involvement and potential role of the brain's connector hub regions in essential tremor

    Epifanio Bagarinao, Satoshi Maesawa, Sachiko Kato, Ryuta Saito

    46th Annual Meeting of the Japan Neuroscience Society  2023.8.3 

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    Event date: 2023.8

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Sendai   Country:Japan  

  3. Impairments of connector hubs in brain disorders Invited

    Epifanio Bagarinao

    25th Congress of Japan Human Brain Mapping Society  2023.2.24 

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    Event date: 2023.2

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Nagoya City   Country:Japan  

  4. Characteristics of the aging brain of healthy older adults: A longitudinal study

    Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Kazuya Kawabata, Kazuhiro Hara, Reiko Ohdake, Aya Ogura, Daisuke Mori, Shuji Koyama, Masahisa Katsuno, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue

    45th Annual Meeting of the Japan Neuroscience Society  2022.7.3  Japan Neuroscience Society

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    Event date: 2022.6 - 2022.7

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Okinawa   Country:Japan  

  5. Brain imaging: From functional mapping to mind reading Invited

    Epifanio Bagarinao

    39th Samahang Pisika ng Pilipinas Physics Conference  2021.10.20  Samahang Pisika ng Pilipinas

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    Event date: 2021.10

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Online   Country:Philippines  

    Other Link: https://proceedings.spp-online.org/article/view/SPP-2021-INV-1D-02

  6. Schizophrenia significantly impacts the overall connectivity strength of brain hubs

    Epifanio Bagarinao, Maeri Yamamoto, Masanori Shimamoto, Norio Ozaki

    44th Annual Meeting of the Japan Neuroscience Society  2021.7.29  Japan Neuroscience Society

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    Event date: 2021.7

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Kobe   Country:Japan  

  7. Unraveling the aging brain Invited

    Bagarinao Epifanio

    Brain & Mind Research Center Annual Symposium  2021.1.27 

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    Event date: 2021.1

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Nagoya   Country:Japan  

  8. Facilitating learning of motor imagery tasks in the elderly using neurofeedback

    Epifanio Bagarinao, Akihiro Yoshida, Mika Ueno, Shohei Kato, Toshiharu Nakai

    43rd Annual Meeting of the Japan Neuroscience Society 

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    Event date: 2020.7 - 2020.8

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Online   Country:Japan  

  9. Structural and functional changes in the aging brain Invited International conference

    Bagarinao Epifanio

    40th Annual PAASE Meeting and Symposium  2020.7.23 

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    Event date: 2020.7 - 2020.8

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Online  

  10. Structural MRI spatial pattern associated with schizophrenia patients in a multivariate approach International conference

    Maeri Yamamoto, Epifanio Bagarinao, Itaru Kushima, Toshiya Inada, Tetsuya Iidaka, Norio Ozaki

    26th Annual Meeting of the Organization for Human Brain Mapping 

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    Event date: 2020.6 - 2020.7

    Language:English   Presentation type:Poster presentation  

    Venue:Online  

  11. Age related change of brain activation during NF-fMRI training using a small humanoid robot agent International conference

    Toshiharu Nakai, Akihiro Yoshida, Mika Ueno, Shohei Kato, Epifanio Bagarinao

    26th Annual Meeting of the Organization for Human Brain Mapping 

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    Event date: 2020.6 - 2020.7

    Language:English   Presentation type:Poster presentation  

    Venue:Online  

  12. The aging brain: Changes in large-scale functional networks over the adult lifespan Invited International conference

    Bagarinao Epifanio

    BrainConnects 2019 

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    Event date: 2019.10

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Taguig City   Country:Philippines  

  13. Age-related changes in whole-brain connectivity across the adult lifespan: The BMRC aging cohort study

    Bagarinao Epifanio

    42nd Annual Meeting of the Japan Neuroscience Society 

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    Event date: 2019.7

    Language:English   Presentation type:Poster presentation  

    Venue:Niigata   Country:Japan  

  14. Age-related distance-dependent connectivity changes in hub regions over the adult lifespan International conference

    Bagarinao Epifanio

    25th Annual Meeting of the Organization for Human Brain Mapping 

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    Event date: 2019.6

    Language:English   Presentation type:Poster presentation  

    Venue:Rome   Country:Italy  

  15. Incremental SVM training improves real-time neurofeedback brain state classification International conference

    Bagarinao Epifanio

    25th Annual Meeting of the Organization for Human Brain Mapping 

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    Event date: 2019.6

    Language:English   Presentation type:Poster presentation  

    Venue:Rome   Country:Italy  

  16. Real-time functional MRI-based neurofeedback improves volitional recall of brain activation patterns during motor imagery training International conference

    Bagarinao Epifanio

    BrainConnects 2018 

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    Event date: 2018.6

    Language:English   Presentation type:Poster presentation  

    Venue:Singapore   Country:Singapore  

  17. Brain changes across the adult lifespan assessed using a data-driven structural brain parcellation International conference

    Bagarinao Epifanio

    24th Annual Meeting of the Organization for Human Brain Mapping 

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    Event date: 2018.6

    Language:English   Presentation type:Poster presentation  

    Venue:Singapore   Country:Singapore  

  18. Neurofeedback improves the classification of brain activation patterns during motor imagery task training: A real-time functional MRI study

    Bagarinao Epifanio

    2nd ISMRM Japanese Chapter Meeting 

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    Event date: 2018.2

    Language:English   Presentation type:Poster presentation  

    Venue:Saitama   Country:Japan  

  19. Use of a small humanoid robot as a neurofeedback system for motor imagery tasks International conference

    Bagarinao Epifanio

    Real-Time Functional Imaging and Neurofeedback (rtFIN2017) Conference 

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    Event date: 2017.11 - 2017.12

    Language:English   Presentation type:Poster presentation  

    Venue:Nara   Country:Japan  

  20. Application of Real Time Functional MRI for Motor Imagery Task Training Invited International conference

    Bagarinao Epifanio

    BrainConnects 2017 

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    Event date: 2017.8

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Kuala Lumpur   Country:Malaysia  

  21. Using multimodal neuroimaging to detect sub-second activation dynamics: A simultaneous EEG-fMRI study

    Bagarinao Epifanio

    40th Annual Meeting of the Japan Neuroscience Society 

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    Event date: 2017.7

    Language:English  

    Venue:Chiba   Country:Japan  

  22. Examining functional connectivity changes in the diseased brain using resting state fMRI: Methods and applications Invited International conference

    Bagarinao Epifanio

    BrainConnects 2016 

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    Event date: 2016.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Taichung   Country:Taiwan, Province of China  

  23. Sub-second activation dynamics of the oddball task: A simultaneous EEG-fMRI study

    Bagarinao Epifanio

    39th Annual Meeting of the Japan Neuroscience Society 

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    Event date: 2016.7

    Language:English  

    Venue:Yokohama   Country:Japan  

  24. Detecting subsecond activation changes during interictal epileptic spike using simultaneous EEG-fMRI International conference

    Bagarinao Epifanio, Maesawa Satoshi, Ito Yuji, Watanabe Hirohisa, Isoda Haruo

    22nd Annual Meeting of the Organization for Human Brain Mapping 

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    Event date: 2016.6

    Language:English   Presentation type:Poster presentation  

    Venue:Geneva   Country:Switzerland  

  25. Neuroimaging as a tool for detecting, characterizing and managing pain Invited

    Bagarinao Epifanio

    38th Annual Meeting of the Japanese Association for the Study of Pain 

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    Event date: 2016.6

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Sapporo   Country:Japan  

  26. Novel neuroimaging approaches for exploring cerebral functional and anatomical connectivity Invited

    Bagarinao Epifanio, Watanabe Hirohisa, Naganawa Shinji, Sobue Gen

    57th Annual Meeting of the Japanese Society of Neurology 

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    Event date: 2016.5

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Kobe   Country:Japan  

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KAKENHI (Grants-in-Aid for Scientific Research) 13

  1. 神経障害性疼痛に特異的な脳内神経回路の解析による病態解明と治療効果予測

    Grant number:24K12260  2024.4 - 2027.3

    科学研究費助成事業  基盤研究(C)

    種井 隆文, Bagarinao E., 西村 由介, 永島 吉孝, 前澤 聡

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    Authorship:Coinvestigator(s) 

    脊髄刺激療法(SCS)は神経障害性疼痛に対する治療法であるが、中枢性神経障害性疼痛では効果を示す/示さない患者の差が大きく、術前に治療効果を予測できない課題がある。近年、新たなSCS刺激法が開発され、治療効果の向上が期待される。本研究の目的は、中枢性疼痛に最適な刺激法を前方視的に検証し、脳内ネットワークを可視化し痛みに特異的な変化を同定することである。脳内ネットワーク評価には、安静時機能的MRIから脳内のコネクトームの変化を各領域で数値化できるFCORという技術を用いる。保有している健常人コホートデータと比較し、神経障害性疼痛に特異的な脳内コネクトームの変化を解明する。

  2. デジタルマーカーとfMRIによる振戦疾患の病態解明と集束超音波の治療効果判定

    Grant number:24K10489  2024.4 - 2027.3

    科学研究費助成事業  基盤研究(C)

    坪井 崇, Bagarinao E., 勝野 雅央, 鈴木 将史, 石崎 友崇

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    本研究では、パーキンソン病、本態性振戦、ジストニア性振戦といった振戦性疾患の根底にある脳ネットワークの異常を明らかにし、新しい治療法の可能性を探求する。特に、fMRIと集束超音波治療(FUS)を通して病態解明を目指すとともに、デジタルバイオマーカーを用いた診断法の開発も並行して行う。3つの異なる振戦性疾患を横断的に解析することも本研究の特徴であり、上記の目標に効果的と考えられる。本研究は振戦性疾患の治療法の進化に寄与し、患者のQOL向上に繋がることが期待される。

  3. Research for development of connectome-based functional neurosurgery and non-invasive simulation system

    Grant number:22H03184  2022.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  4. Real-time precision functional network mapping of the human brain for neurosurgical applications

    Grant number:21K09149  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

  5. 統合失調症における加齢に伴う脳神経回路病態を解明する

    Grant number:21K07498  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    山本 真江里, Bagarinao E.

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    Authorship:Coinvestigator(s) 

    統合失調症は全人口の約1%が罹患し、陽性症状、陰性症状、及び認知機能障害を特徴とする多彩な精神症状を呈する。多くは思春期に発症し慢性・進行性経過をたどる。統合失調症患者の多くは、疾病経過とともに陽性症状は減弱する反面、いわゆる陰性症状とよばれる認知機能障害が進行性に優勢になり、社会機能の低下をきたす。実臨床では、高齢のいわゆる慢性化した統合失調症患者の社会復帰は困難であり、治療的観点からも病因病態の明確化とその治療戦略がのぞまれている。本研究では、脳の磁気共鳴画像(magnetic resonance imaging: MRI)を用いて、加齢に伴う脳構造変化とそれに伴う機能の変化を捉える。
    統合失調症の多くは思春期に発症し慢性・進行性経過をたどるとされている。実臨床では、 高齢のいわゆる慢性化した統合失調症患者の社会復帰は困難であ り、病因病態の明確化とその治療戦略が望まれている。脳の磁気共鳴画像(magnetic resonance imaging: MRI)を用いた研究から、疾病の経過と ともに経時的に 脳容積が減少することが報告されているが、functional MRI (fMRI)画像を 用いた検討はされておらず、脳機能ないし神経回路の観点からは十分な検証がされて いない。 今回、この疾患で加齢に伴う脳構造変化とそれに伴う機能の変化に焦点をあて、名古屋大学脳とこころの研究センターの健常者コホートで検証した データ駆動型アプローチを用い、脳構造および脳内ネットワークの結合性の変化を捉える。 既報の研究で統合失調症のMRIデータを取得しており、それに加えて、50歳代以上の患者データを収集することを目標としてたが、取得したMRIデータの年齢構成は30歳代1名、40歳代6名、50歳代2名だった。引き続き、60歳代以降の統合失調症患者を中心にデータを取得する必要がある。 MRI解析方法については、新規ネットワーク指標であるFunctional connectivity overlap ratio (FCOR)(Bagarinao,et al., 2020)を用いて統合失調症における connector hubの障 害を検討した。複数の大規模安静時ネットワークとの結合が変化している脳内voxelを、FCORを用いて調べ、統合失調症では、小脳、中脳、 視床などにおいて connector hubが障害されていることを英文雑誌で報告した。
    既報の研究ですでに一定数の統合失調症患者のMRIデータを取得しているが、加齢にともなう脳構造変化及びそれに伴う機能の変化を検証するためには50歳代以降の統合失調症患者のデータを更に取得する必要がある。高齢の統合失調症患者の研究参加者募集にやや遅延が生じている。
    既報の研究で取得したMRIデータを用いて、新規ネットワーク指標であるFunctional connectivity overlap ratio (FCOR)(Bagarinao,et al., 2020)により統合 失調症におけるconnector hubの障害を検討し、統合失調症では、小脳、中脳、視床などにおいて connector hubが障害されていることを英文雑誌で報告した(NeuroImage: Clinical, 2022)。この成果をもとに統合失調症における加齢によるconnector hubの変化を検討する。
    2022年度までに取得したデータを用いて、予備的解析を開始している。引き続き50歳代以降の統合失調症の患者データ及び臨床データを収集していく。

  6. Development of evaluation method for chronic pain and brain network dysfunction

    Grant number:20K07881  2020.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Hoshiyama Minoru

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  7. Estimation of cognitive error risk by using neurofeedback driven dynamic functional connectivity

    Grant number:19H04025  2019.4 - 2022.3

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Nakai Toshiharu

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  8. Connectome map for epilepsy surgery originated by network imaging analysis and its justification by stereotactic electroencephalography (SEEG)

    Grant number:17K10890  2017.4 - 2020.3

    Maesawa Satoshi

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    Authorship:Coinvestigator(s) 

    The purpose of this study was to evaluate epileptogenic networks in focal epilepsy using novel modalities such as rsfMRI, MEG, and EEG-fMRI, create the connectome map, and justify with stereotactic electroencephalography (SEEG). Multilayer analysis with rsfMRI revealed epileptogenic hubs near the focus with excitatory connection to the contralateral hubs and inhibitory connections to the default mode network, and this may reflect pathological mechanism in focal epilepsy. Modified DS(distributed source) analysis in MEG and subsecond analysis in EEG-fMRI improved detection of epileptic focus and its networks. Novel metrics for demonstrating connectivity to canonical networks were created, and used as a connectome map. SEEG analyzed with coherence showed relationship between epileptic focus and its networks.

  9. Pathological elucidation of tremor by various modality and modification by Focal Ultrasounds and Deep Brain Stimulation

    Grant number:17K10891  2017.4 - 2020.3

    Nakatsubo Daisuke

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    Authorship:Coinvestigator(s) 

    MRgFUS (MR-guided focused ultrasound) has become possible in Japan as a non-invasive coagulation therapy for the treatment of involuntary movements such as essential tremor. In this study, the improvement rate of the upper limbs was about 65% one year after treatment, and no serious complications were observed. In addition, network analysis by resting fMRI revealed that the more severe the tremor, the lower the connectivity of the network, and the higher brain function mainly in the frontal lobe is also impaired.

  10. Classifying Older Adults Based on the Initial Response in Physical & Cognitive Exercise Prescription

    Grant number:15H03104  2015.4 - 2019.3

    NAKAI Toshiharu

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    Authorship:Coinvestigator(s) 

    Neuroimaging biomarkers to forecast the short (4 weeks) or long-term effects of physical and cognitive exercise prescriptions were explored using fMRI. It was suggested that the resting state (RS) activation in the anterior cingulate gyrus may be the potential indicator in both terms. To more specifically extract the response to cognitive stress in older adults, a neurofeedback fMRI system using a small humanoid robot was developed. The RS activation in the posterior cingulate gyrus and visual network was deactivated depending on the neurofeedback training, while such deactivation was not observed in the older adults, suggesting decline of cognitive reserve. An fMRI study using a trustworthy task suggested that the first impression dominates the judgement of trustworthiness even after disclosing the ‘fact’. Decline of cognitive processing to update interpersonal impression may be considered to conduct interventions for older adults.

  11. Development of a New 4-Dimensional, Multilayered, Surgery-Assisting Platform with Multimodal Optic-Radiological Image Integration (MORI)

    Grant number:15H04948  2015.4 - 2019.3

    FUJII MASAZUMI

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    Authorship:Coinvestigator(s) 

    There have been remarkable advancements in the neurosurgical operation theaters, such as operative microscopes, endoscopes, fluorescence imaging and blood flow imaging. Moreover, intraoperative brain mapping has become common to localize and evaluate brain functions. In our study, we have developed a new image integration technology which allow us to fuse among various optical imaging modalities and radiological images, such as images of MRI and CT (Multimodal Optico-Radiological Image Integration; MORI). We have confirmed usefulness of the technology in several clinical settings, demonstrating that it enable us to identify both functional brain areas obtained by intraoperative brain mapping, and remnant tumor infiltrating bran areas shown by intraoperative fluorescence imaging on anatomical images. The technology could enhance future development of a new and comprehensive surgical information platform.

  12. Analysis of temporal and spatial brain circuit using real-time simultaneous electroencephalography and functional magnetic resonance imaging

    Grant number:15K15338  2015.4 - 2017.3

    WATANABE Hirohisa

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    We aim to resolve the spatiotemporal changes in brain activation using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) recordings. We proposed a method that employed whole scalp EEG data to generate regressors needed for the analysis of fMRI using the general linear model. Using simultaneous EEG-fMRI recordings from healthy subjects and patients with epilepsy, we obtained activation maps showing brain regions that were consistent with working memory task and suspected or confirmed sources of the epileptogenic activity. We also identified spatiotemporal activation patterns during epileptic spikes that include sequential activation of multiple brain regions involved, shifting location of the peak activation, and local spreading of activated regions. These findings demonstrated the efficacy of the method in resolving rapidly changing activation patterns with sub-second temporal resolution observed during cognitive task and epileptic spikes.

  13. Learning to control brain activity pattern using real-time functional MRI: A feasibility study

    Grant number:26350993  2014.4 - 2017.3

    Bagarinao Epifanio

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    Authorship:Principal investigator 

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    In this study, a real-time fMRI-based brain state decoder system to identify different brain states, viewed as brain activity pattern, was developed and used to investigate whether participants can control their brain activity pattern to match a pre-determined target pattern using neurofeedback. The system attained an overall processing time that was faster than the image acquisition time set at 2s. Using support vector machines, brain states associated with three tasks (imagined tapping, word generation, and serial subtraction tasks) were successfully reproduced as evidenced by the consistently high mean classification accuracy of greater than 80% during feedback scans.

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Teaching Experience (On-campus) 7

  1. Introduction to Health Care and Medical Technology

    2021

  2. Introduction to Health Science Data Analysis

    2021

  3. Practice in Health informatics II

    2021

  4. Practice in Health informatics I

    2021

  5. An introduction to data science I

    2021

  6. Introduction to Data Science

    2020

  7. Introduction to Health Science Data Analysis

    2020

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