Updated on 2021/07/07

写真a

 
KOMINE Okiru
 
Organization
Research Institute of Environmental Medicine Division of Stress Recognition and Response Assistant Professor
Graduate School of Medicine
Title
Assistant Professor
External link

Degree 1

  1. 博士(医学) ( 2007.3   東京医科歯科大学 ) 

Research History 4

  1. 名古屋大学 環境医学研究所 助教

    2013.8

      More details

    Country:Japan

  2. 独立行政法人 理化学研究所 脳科学総合研究センター 研究員

    2012.1 - 2013.7

      More details

    Country:Japan

  3. 東京医科歯科大学 難治疾患研究所 分子神経科学分野 助教

    2008.4 - 2010.12

      More details

    Country:Japan

  4. 東京医科歯科大学大学院 21世紀COEプログラム特別研究員

    2007.4 - 2008.3

      More details

    Country:Japan

Education 3

  1. Tokyo Medical and Dental University

    2003.4 - 2007.3

      More details

    Country: Japan

  2. Tokyo University of Science

    2001.4 - 2003.3

      More details

    Country: Japan

  3. Tokyo University of Science   Faculty of Science and Engineering

    1997.4 - 2001.3

      More details

    Country: Japan

Professional Memberships 3

  1. 日本神経科学学会

  2. Society for Neuroscience

  3. 日本神経免疫学会

Awards 4

  1. 若手優秀論文賞

    2019.10   名古屋大学 環境医学研究所  

  2. 21世紀COE若手研究者シンポジウム研究発表会 優秀研究員賞

    2006.3   東京医科歯科大学  

    小峯起

     More details

    Country:Japan

  3. 21世紀COE若手研究者シンポジウム研究発表会 優秀研究員賞

    2004.3   東京医科歯科大学  

    小峯起

     More details

    Country:Japan

  4. 小玉記念科学賞

    2003.3   財団法人科学技術振興会  

     More details

    Award type:Award from publisher, newspaper, foundation, etc. 

 

Papers 26

  1. Novel reporters of mitochondria-associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis.

    Sakai S, Watanabe S, Komine O, Sobue A, Yamanaka K

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology   Vol. 35 ( 7 ) page: e21688   2021.7

     More details

    Language:English  

    DOI: 10.1096/fj.202100137R

    PubMed

  2. Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease Reviewed

    Sobue Akira, Komine Okiru, Hara Yuichiro, Endo Fumito, Mizoguchi Hiroyuki, Watanabe Seiji, Murayama Shigeo, Saito Takashi, Saido Takaomi C., Sahara Naruhiko, Higuchi Makoto, Ogi Tomoo, Yamanaka Koji

    ACTA NEUROPATHOLOGICA COMMUNICATIONS   Vol. 9 ( 1 )   2021.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40478-020-01099-x

    Web of Science

  3. Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction Reviewed

    Konishi Hiroyuki, Okamoto Takayuki, Hara Yuichiro, Komine Okiru, Tamada Hiromi, Maeda Mitsuyo, Osako Fumika, Kobayashi Masaaki, Nishiyama Akira, Kataoka Yosky, Takai Toshiyuki, Udagawa Nobuyuki, Jung Steffen, Ozato Keiko, Tamura Tomohiko, Tsuda Makoto, Yamanaka Koji, Ogi Tomoo, Sato Katsuaki, Kiyama Hiroshi

    EMBO JOURNAL   Vol. 39 ( 22 )   2020.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.15252/embj.2020104464

    Web of Science

  4. Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer's disease Reviewed

    Saifullah Md. Ali Bin, Komine Okiru, Dong Yutao, Fukumoto Kazuya, Sobue Akira, Endo Fumito, Saito Takashi, Saido Takaomi C., Yamanaka Koji, Mizoguchi Hiroyuki

    MOLECULAR BRAIN   Vol. 13 ( 1 )   2020.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13041-020-00690-6

    Web of Science

  5. Aggresome formation and liquid-liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43 Reviewed

    Watanabe Seiji, Inami Hidekazu, Oiwa Kotaro, Murata Yuri, Sakai Shohei, Komine Okiru, Sobue Akira, Iguchi Yohei, Katsuno Masahisa, Yamanaka Koji

    CELL DEATH & DISEASE   Vol. 11 ( 10 )   2020.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41419-020-03116-2

    Web of Science

  6. Hypothalamic glial cells isolated by MACS reveal that microglia and astrocytes induce hypothalamic inflammation via different processes under high-fat diet conditions Reviewed

    Sugiyama Mariko, Banno Ryoichi, Yaginuma Hiroshi, Taki Keigo, Mizoguchi Akira, Tsunekawa Taku, Onoue Takeshi, Takagi Hiroshi, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Suga Hidetaka, Komine Okiru, Yamanaka Koji, Arima Hiroshi

    NEUROCHEMISTRY INTERNATIONAL   Vol. 136   2020.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neuint.2020.104733

    Web of Science

  7. Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair Reviewed

    Nakazawa Yuka, Hara Yuichiro, Oka Yasuyoshi, Komine Okiru, van den Heuvel Diana, Guo Chaowan, Daigaku Yasukazu, Isono Mayu, He Yuxi, Shimada Mayuko, Kato Kana, Jia Nan, Hashimoto Satoru, Kotani Yuko, Miyoshi Yuka, Tanaka Miyako, Sobue Akira, Mitsutake Norisato, Suganami Takayoshi, Masuda Akio, Ohno Kinji, Nakada Shinichiro, Mashimo Tomoji, Yamanaka Koji, Luijsterburg Martijn S., Ogi Tomoo

    CELL   Vol. 180 ( 6 ) page: 1228   2020.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cell.2020.02.010

    Web of Science

  8. ALS-linked TDP-43(M337V) knock-in mice exhibit splicing deregulation without neurodegeneration Reviewed

    Watanabe Seiji, Oiwa Kotaro, Murata Yuri, Komine Okiru, Sobue Akira, Endo Fumito, Takahashi Eiki, Yamanaka Koji

    MOLECULAR BRAIN   Vol. 13 ( 1 )   2020.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13041-020-0550-4

    Web of Science

  9. Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway. Reviewed

    Nishino K, Watanabe S, Shijie J, Murata Y, Oiwa K, Komine O, Endo F, Tsuiji H, Abe M, Sakimura K, Mishra A, Yamanaka K

    Acta neuropathologica communications   Vol. 7 ( 1 ) page: 118   2019.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40478-019-0776-5

    PubMed

  10. The multi-dimensional roles of astrocytes in ALS Reviewed

    Yamanaka K, Komine O

    NEUROSCIENCE RESEARCH   Vol. 126   page: 31-38   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neures.2017.09.011

    Web of Science

    PubMed

  11. Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes Reviewed

    Komine O, Yamashita H, Fujimori-Tonou N, Koike M, Jin S, Moriwaki Y, Endo F, Watanabe S, Uematsu S, Akira S, Uchiyama Y, Takahashi R, Misawa H, Yamanaka K

    Cell Death and Differentiation     2018

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41418-018-0098-3

    PubMed

  12. Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice Reviewed

    Watanabe S, Komine O, Endo F, Wakasugi K, Yamanaka K

    Journal of Neurochemistry     2017.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jnc.14285

    PubMed

  13. Mice heterozygously lacking C-terminal domain of TDP-43 show age-dependent motor dysfunction

    Nishino K., Watanabe S., Komine O., Endo F., Yamanaka K.

    JOURNAL OF THE NEUROLOGICAL SCIENCES   Vol. 381   page: 570-570   2017.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jns.2017.08.1604

    Web of Science

  14. Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS. Reviewed

    Watanabe S, Ilieva H, Tamada H, Nomura H, Komine O, Endo F, Jin S, Mancias P, Kiyama H, *Yamanaka K.

    EMBO Mol Med   Vol. 8   page: 1421-1437   2016.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.15252/emmm.201606403.

  15. Neuroinflammation in motor neuron disease.

    Endo F, Komine O, Yamanaka K.

    Clinical and Experimental Neuroimmunology   Vol. 7   page: 126-138   2016.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cen3.12309

  16. Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons. Reviewed

    Lasiene J, Komine O, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Shijie J, Ravits J, Horner P, Misawa H, *Yamanaka K

    Acta Neuropathologica Communications   Vol. 4 ( 15 )   2016.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40478-016-0286-7

    PubMed

  17. Neuroinflammation in motor neuron disease Reviewed

    Okiru Komine, Koji Yamanaka

    Nagoya Journal of Medical Science   Vol. 77 ( 4 ) page: 537 - 549   2015.11

     More details

    Authorship:Lead author   Language:English  

  18. Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells Reviewed

    Endo F, Komine O, Fujimori-Tonou N, Katsuno M, Jin S, Watanabe S, Sobue G, Dezawa M, Wyss-Coray T, Yamanaka K

    Cell Reports   Vol. 11 ( 4 ) page: 592-604   2015.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: http://dx.doi.org/10.1016/j.celrep.2015.03.053

  19. SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system. Reviewed

    Watanabe S, Ageta-Ishihara N, Nagatsu S, Takao K, Komine O, Endo F, Miyazawa T, Misawa H, Takahashi R, Kinoshita M, Yamanaka K

    Molecular Brain   Vol. 7   page: 62   2014.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

  20. Delta-like 1 regulates bergmann glial monolayer formation during cerebellar development. Reviewed

    Hiraoka Y, Komine O, Nagaoka M, Bai N, Hozumi K, Tanaka K

    Molecular Brain   Vol. 6   page: 25-36   2013.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  21. RBP-J promotes the maturation of neuronal progenitors. Reviewed

    Komine O, Nagaoka M, Hiraoka Y, Hoshino M, Kawaguchi Y, S. Pear W, Tanaka K

    Development Biology   Vol. 354 ( 1 ) page: 44-54   2011.6

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  22. The monolayer formation of Bergmann glial cells is regulated by Notch/RBP-J signaling. Reviewed

    Komine O, Nagaoka M, Watase K, H. Gutmann D, Tanigaki K, Honjo T, Radtke F, Saito T, Chiba S, Tanaka K

    Developmental Biology   Vol. 311 ( 1 ) page: 238-250   2007.11

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  23. Imprinting modulates processing of visual information in the visual wulst of chicks. Reviewed

    Maekawa F, Komine O, Sato K, Kanamatsu T, Uchimura M, Tanaka K, Ohki-Hamazaki H.

    BMC Neuroscience   Vol. 7   page: 75-87   2006.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1471-2202-7-75

  24. Differential roles of glial and and neuronal glutamate transporters in Purkinje cells synapses. Reviewed

    Takayasu Y, Iino M, Kakegawa W, Maeno H, Watase K, Wada K, Yanagihara D, Miyazaki T, Komine O, Watanabe M, Tanaka K, Ozawa S.

    The Journal of Neuroscience   Vol. 25 ( 38 ) page: 8788-8793   2005.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1523/JNEUROSCI.1020-05.2005

  25. The Runx1 transcription factor inhibits the differentiation of naive CD4+T cells into the Th2 lineage by repressing GATA3 expression. Reviewed

    Komine O, Hayashi K, Natsume W, Watanabe T, Seki Y, Seki N, Yagi R, Suzuki W, Tamauchi H, Hozumi K, Habu S, Kubo M, Satake M.

    The Journal of Experimental Medicine   Vol. 198 ( 1 ) page: 51-61   2003.7

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1084/jem.20021200

  26. SOCS-3 regulates onset and maintenance of Th2-mediated allergic responses. Reviewed

    Seki Y, Inoue H, Nagata N, Hayashi K, Fukuyama S, Matsumoto K, Komine O, Hamano S, Himeno K, Inagaki-Ohara K, Cacalano K, O'Garra A, Oshida T, Saito H, Johnston JA, Yoshimura A, Kubo M.

    Nature Medicine   Vol. 9 ( 8 ) page: 1047-1054   2003.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi:10.1038/nm896

▼display all

Books 10

  1. 筋萎縮性側索硬化症、前頭側頭型認知症と炎症

    小峯起、山中宏二( Role: Joint author)

    老年精神医学雑誌  2020.7 

  2. 筋萎縮性側索硬化症におけるグリア・免疫連関

    小峯起、山中宏二( Role: Joint author)

    実験医学増刊  2019.11 

  3. アストロサイト. 脳内環境辞典

    小峯 起、山中宏二( Role: Joint author)

    メディカルドゥ  2017.3 

     More details

    Language:Japanese Book type:Scholarly book

  4. Modern Physician:免疫性・炎症性神経疾患―病態解明から疾患修飾薬開発まで):免疫性神経疾患の基礎科学--神経科学の立場から

    小峯 起、山中宏二( Role: Joint author)

    新興医学出版社  2016.7 

     More details

    Language:Japanese

  5. Clinical Neuroscience 別冊「ミクログリア」:ALSとミクログリア

    小峯 起、山中宏二( Role: Joint author)

    中外医学社  2015.12 

     More details

    Language:Japanese

  6. Nagoya Journal of Medical Science: Neuroinflammation in motor neuron disease.

    Komine O, Yamanaka K( Role: Joint author)

    2015.11 

     More details

    Language:English

  7. グリア-末梢免疫組織連関からみた神経変性機序の解明-筋萎縮性側索硬化症を中心として-. 遺伝子医学MOOK 脳内環境-維持機構と破綻がもたらす疾患研究

    小峯 起、山中宏二( Role: Joint author)

    メディカルドゥ  2014 

     More details

    Language:Japanese

  8. グリア関連病態. すべてがわかるALS(筋萎縮性側索硬化症)・運動ニューロン疾患

    山中宏二、小峯 起( Role: Joint author)

    中山書店  2013.5 

     More details

    Language:Japanese

  9. Clinical Neuroscience ニューロサイエンスの最新情報:神経変性疾患における非細胞自律性神経細胞死-遺伝性ALSモデルマウスを中心として.

    小峯 起、山中宏二( Role: Joint author)

    中外医学社  2013 

     More details

    Language:Japanese

  10. 臨床免疫:転写因子Runx1におけるTh2への分化抑制

    小峯 起、佐竹正延、久保允人( Role: Joint author)

    科学評論社  2004 

     More details

    Language:Japanese

▼display all

Presentations 43

  1. ADにおけるミクログリアのカンナビノイド受容体2型を介した神経炎症調節について.

    祖父江 顕、小峯  起、遠藤史人、村山繁雄、斉藤貴志、西道隆臣、山中宏二

    第39回日本認知症学会学術集会 

     More details

    Event date: 2020.11

  2. アルツハイマー病モデルにおける神経炎症に対する全身炎症が与える影響の検討

    下川梨津子、小峯 起、伊藤綾香、祖父江 顕、斉藤貴志、西道隆臣、菅波孝祥、山中宏二

    第39回日本認知症学会学術集会 

     More details

    Event date: 2020.11

  3. Effect of Dimethyl Fumarate on the neuroinflammation in App Knock-in mouse.

    Wang T. Sobue A, Koine O, Saito T, Saido T, Yamanaka K.

     More details

    Event date: 2020.11

  4. 筋萎縮性側索硬化症における末梢免疫環境の役割解明

    小峯 起、山中宏二

    第93回日本生化学会大会シンポジウム 

     More details

    Event date: 2020.9

  5. Multimerization of TDP-43 plays a key role in determination of its subcellular localization.

     More details

    Event date: 2020.8 - 2020.9

  6. ALS関連変異TDP-43M337Vノックインマウスは運動神経変性を伴わないスプライシング異常を生じる

    渡邊征爾、大岩康太郎、小峯 起、祖父江 顕、山中宏二

    第43回日本神経科学大会 

     More details

    Event date: 2020.7 - 2020.8

    Presentation type:Oral presentation (general)  

  7. ALSモデルマウスにおける神経保護性ミクログリア反応を誘導する末梢免疫関連分子の探索

    小峯  起、村上由希、大沼周平、池田早織、山中宏二

    第43回日本神経科学大会 

     More details

    Event date: 2020.7 - 2020.8

  8. ミクログリアのカンナビノイド 受容体2型を標的としたアルツハイマー病治療法開発

    祖父江 顕、小峯 起、遠藤史人、村山繁雄、斉藤貴志、西道隆臣、山中宏二

    第43回日本神経科学大会 

     More details

    Event date: 2020.7 - 2020.8

  9. ALSモデルマウスのミクログリア機能を変化させる末梢免疫関連分子の同定

    小峯 起、大沼周平、池田沙織、山中宏二

    第42回日本神経科学大会第62回日本神経化学会大会 

     More details

    Event date: 2019.7

    Language:Japanese   Presentation type:Poster presentation  

    Venue:新潟   Country:Japan  

  10. TDP-43の多量体化が、その細胞内局在の決定に重要である

    大岩康太郎、渡邊征爾、祖父江 顕、小峯 起 、勝野雅央、山中宏二

    第42回日本神経科学大会第62回日本神経化学会大会 

     More details

    Event date: 2019.7

    Language:Japanese   Presentation type:Poster presentation  

    Venue:新潟市   Country:Japan  

  11. アルツハイマー病患者脳とAPP- KIマウス由来ミクログリアにおける遺伝子発現解析

    祖父江 顕、小峯 起、遠藤史人、村山繁雄、斉藤貴志、西道 隆臣、山中宏二

    第42回日本神経科学大会第62回日本神経化学会大会 

     More details

    Event date: 2019.7

    Language:Japanese   Presentation type:Poster presentation  

    Venue:新潟市   Country:Japan  

  12. Innate immune adaptor TRIF confers neuroprotection in ALS mice by eliminating abnormal astrocytes International conference

    Komine O, Yamashita H, Fujimori-Tonou N, Koike M, Jin S, Moriwaki Y, Endo F, Watanabe S, Uematsu S, Akira S, Uchiyama Y, Takahashi R, Misawa H, Yamanaka K

    Society for Neuroscience2018 Annual Meeting 

     More details

    Event date: 2018.11

    Language:English   Presentation type:Poster presentation  

    Venue:San Diego   Country:United States  

  13. 早期アルツハイマー病理を呈する患者脳における神経炎症関連遺伝子発現解析

    祖父江顕、遠藤史人、小峯 起、村山繁雄、山中宏二

    第37回日本認知症学会学術集会 

     More details

    Event date: 2018.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  14. The peripheral immune environmental shift affects microglial functions in amyotrophic lateral sclerosis mice

    Komine O, Ohnuma S, Ikeda S, Yamanaka K

     More details

    Event date: 2018.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  15. Elucidating the influence of peripheral immune environment on microglial functions in amyotrophic lateral sclerosis mice

     More details

    Event date: 2018.7

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  16. Innate immune adaptor TRIF slows disease progression of ALS mice by eliminating aberrantly activated astrocytes International conference

    Komine O, Yamashita H. Fujimori-Tonou N, Uematsu S, Akira S, Yamanaka K

    28th International symposium on ALS/MND 

     More details

    Event date: 2017.12

    Language:English   Presentation type:Poster presentation  

    Venue:Boston   Country:Japan  

  17. 筋萎縮性側索硬化症におけるシスタチンCの神経保護効果

    渡邊征爾、小峯 起、遠藤史人、山中宏二

    2017年度生命科学系学会合同年次大会(ConBio2017) 

     More details

    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  18. グリオシドGD3によるグリオーマの腫瘍微小環境の制御機構.

    張 璞、大川裕樹、加藤 彰、小峯 起、百田洋之、Robiul Bhuiyan、大海 雄介、古川 圭子、若林俊彦、岡島徹也、山中宏二、古川鋼一

    2017年度生命科学系学会合同年次大会(ConBio2017) 

     More details

    Event date: 2017.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  19. The role of peripheral immune system on microglial functions in amyotrophic lateral sclerosis mice.

     More details

    Event date: 2017.7

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  20. 小胞体・ミトコンドリア膜間領域は、筋萎縮性側索硬化症(ALS)の新規治療標的である

    渡邊征爾、小峯 起、遠藤史人、山中宏二

    第40回日本神経科学大会 

     More details

    Event date: 2017.7

    Language:Japanese   Presentation type:Poster presentation  

    Venue:千葉市   Country:Japan  

  21. Neuregulin 1 confers neuroprotection in SOD1-linked ALS mice via restoration of C-boutons of spinal motor neurons. International conference

    Komine O, Lasiene J, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Jin S, Ravits J, Horner P, Misawa H, Yamanaka K.

    The 27th International Symposium on ALS/MND 

     More details

    Event date: 2016.12

    Language:English   Presentation type:Poster presentation  

    Venue:Dublin   Country:Japan  

  22. ALS病態における末梢免疫の役割.

    大沼周平、小峯 起、山中宏二

    第38回日本生物学的精神医学会・第59回日本神経化学会大会合同年会 

     More details

    Event date: 2016.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:福岡市   Country:Japan  

  23. The role of peripheral immune system in amyotrophic lateral sclerosis mice.

     More details

    Event date: 2016.7

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  24. Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by interfering with neuroprotective functions of microglia and T cells. International conference

    ENDO Fumito, KOMINE Okiru, JIN Shijie, WATANABE Seiji, KATSUNO Masahisa, SOBUE Gen, WYSS-CORAY Tony, YAMANAKA Koji

    26th International Symposium on ALS/MLD 

     More details

    Event date: 2015.12

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  25. The role of innate immune TRIF pathway in amyotrophic lateral sclerosis.

     More details

    Event date: 2015.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  26. ALS病態における抹消免疫の役割.

    大沼周平、小峯 起、山中宏二

    第5回名古屋大学医学系研究科・生理学研究所合同シンポジウム 

     More details

    Event date: 2015.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  27. アストロサイト由来TGF-β1はALSの疾患進行を規定する.

    遠藤史人、小峯 起、金 世杰、渡邊征爾、山中宏二

    第27回日本神経免疫学会学術集会 

     More details

    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岐阜   Country:Japan  

  28. Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by regulating the neuroprotective inflammatory response of microglia and T cells.

     More details

    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  29. ALSモデルマウスにおける自然免疫TRIF経路の役割.

    小峯 起、山下博史、藤森典子、森脇康博、三澤 日出巳、山中宏二

    第38回日本神経科学大会 

     More details

    Event date: 2015.7

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  30. ALSマウスの疾患進行におけるアストロサイト由来TGF-β1の役割.

    遠藤史人、小峯 起、金 世杰、勝野雅央、祖父江 元、山中宏二

    第38回日本神経科学大会 

     More details

    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  31. 運動ニューロン特異的26Sプロテアソームノックアウトマウスを用いた運動ニューロンの網羅的遺伝子発現解析

    星野友則、山下博史、田代善祟、三澤日出巳、小峯 起、山中宏二、高橋良輔

    第38回日本神経科学大会 

     More details

    Event date: 2015.7

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸   Country:Japan  

  32. Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by interfering with neuroprotective functions of microglia and T cells. International conference

    ENDO Fumito, KOMINE Okiru, WYSS-CORAY Tony, YAMANAKA Koji

    25th International Symposium on ALS/MND 

     More details

    Event date: 2014.12

    Language:English   Presentation type:Poster presentation  

    Country:Belgium  

  33. The role of the infiltrating immune cells attracted by activated microglia in amyotrophic lateral sclerosis mice. International conference

    Komine O, Yamashita H, Fujimori-Tonou N, Moriwaki Y, Endo F, Watanabe S, Misawa H, Yamanaka K.

    Neuroscience 2014 

     More details

    Event date: 2014.11

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  34. Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by interfering with neuroprotective functions of microglia and T cells. International conference

    ENDO Fumito, KOMINE Okiru, WYSS-CORAY Tony, YAMANAKA Koji

    9th Brain Research Conference 

     More details

    Event date: 2014.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  35. The role of the infiltrating immune cells attracted by activated microglia in amyotrophic lateral sclerosis mice. International conference

    Komine O, Yamashita H, Fujimori-Tonou N, Moriwaki Y, Endo F, Watanabe S, Misawa H, Yamanaka K.

    9th Brain Research Conference 

     More details

    Event date: 2014.11

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  36. 筋萎縮性側索硬化症における浸潤免疫細胞の機能解明.

    小峯 起、山下博史、藤森典子、森脇康博、三澤日出巳、山中宏二

    第37回日本神経科学大会シンポジウム 

     More details

    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  37. 細胞特異的トランスクリプトームを用いた、孤発性ALS患者脊髄のDNAマイクロアレイによる解析.

    山下博史、小峯 起、藤森典子、伊東秀文、井口洋平、熱田直樹、田中章景、祖父江元、髙橋良輔、山中宏二

    第37回日本神経科学大会 

     More details

    Event date: 2014.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

  38. ALSマウスの疾患進行におけるアストロサイト由来TGF-β1の役割.

    遠藤史人、小峯 起、山中宏二

    第37回日本神経科学大会 

     More details

    Event date: 2014.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

  39. Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by interfering with neuroprotective functions of microglia and T cells. International conference

    ENDO Fumito, KOMINE Okiru, WYSS-CORAY Tony, YAMANAKA Koji

    9th FENS Forum for Neuroscience 

     More details

    Event date: 2014.7

    Language:English   Presentation type:Poster presentation  

    Country:Italy  

  40. Deletion of TLR-associated signaling adaptor TRIF significantly accelerates disease progression of ALS mice. International conference

    XI European Meeting on Glial Cell Function in Health and Disease 

     More details

    Event date: 2013.7

    Language:English   Presentation type:Poster presentation  

    Venue:ベルリン(ドイツ)   Country:Germany  

  41. 自然免疫TRIF経路遮断によってALS疾患の進行が顕著に加速する

    小峯 起、藤森典子、山下博史、森脇康博、三澤日出巳、山中宏二

    Neuro2013 第36 回日本神経科学大会 

     More details

    Event date: 2013.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都   Country:Japan  

  42. Elimination of innate immune system adaptor TRIF significantly accelerates disease progression of ALS mice. International conference

    Okiru Komine, Noriko Fujimori-Tonou, Hirofumi Yamashita, Yasuhiro Moriwaki, Hidemi Misawa and Koji Yamanaka

     More details

    Event date: 2012.10

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  43. The profiling of cytokine producing cells in ALS Model mouse spinal cord. International conference

    Okiru Komine, Fumito Endo and Koji Yamanaka

    10th Meeting of International Consortium on Superoxide Dismutase and ALS(ICOSA) 

     More details

    Event date: 2011.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:United Kingdom  

▼display all

Research Project for Joint Research, Competitive Funding, etc. 5

  1. 末梢免疫反応性変容モデルマウスを用いた神経変性疾患の治療標的の同定

    2019.4 - 2021.3

    公益財団法人武田科学振興財団  公益財団法人武田科学振興財団2019年度医学系研究助成 

      More details

    Authorship:Principal investigator 

    公益財団法人 武田科学振興財団

  2. 神経変性における神経・免疫のクロストークに関わる免疫細胞及び関連分子の同定

    2018.4 - 2020.3

    公益財団法人豊秋奨学会  公益財団法人豊秋奨学会平成30年度研究費助成 

      More details

    Authorship:Principal investigator 

    豊秋奨学会2018年度研究助成

  3. 脊髄内浸潤免疫細胞の機能に着目した筋萎縮性側索硬化症の病態解明と治療法開発

    2014.4 - 2015.3

    公益財団法人堀科学芸術振興財団  公益財団法人堀科学芸術振興財団第23回研究助成 

      More details

    Authorship:Principal investigator 

    堀科学芸術振興財団2013年度研究助成

  4. 神経前駆細胞の多様性獲得メカニズムの解明

    2009.4 - 2010.3

    公益財団法人金原一郎記念医学医療振興財団  公益財団法人金原一郎記念医学医療振興財団 第 24 回基礎医学医療研究助成金 

      More details

    Authorship:Principal investigator 

  5. 神経前駆細胞分化メカニズムの解明

    2006.4 - 2007.3

    東京医科歯科大学  東京医科歯科大学 平成 19 年度難治疾患研究所研究助成 

      More details

    Authorship:Principal investigator 

KAKENHI (Grants-in-Aid for Scientific Research) 4

  1. アルツハイマー病の神経炎症における免疫系応答の役割解明

    Grant number:21K07273  2021.4 - 2024.3

    小峯 起

      More details

    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

  2. Elucidating mechanisms of the functional shift toward neuro-toxic astrocyte in amyotrophic lateral sclerosis

    Grant number:17K14963  2017.4 - 2019.3

    Komine Okiru

      More details

    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    To elucidate mechanisms of the functional shift toward neuro-toxic astrocyte in amyotrophic lateral sclerosis, we performed RNA sequencing analyses with magnetic sorted astrocytes from TRIF-deficient and BALB/c background ALS model mouse spinal cords in which a detrimental effect or altered gene expressions in astrocytes were observed. We found that 54 genes including immune functional genes and cell-death-related genes altered in common.

  3. Elucidating pathomechanism of ALS through the abnormality in astrocytes

    Grant number:26293208  2014.4 - 2018.3

    YAMANAKA Koji

      More details

    Authorship:Coinvestigator(s) 

    Using model mice for amyotrophic lateral sclerosis (ALS), we identified cytokine TGF-β1 as a detrimental factor for ALS by interfering a neuroprotective environment mediated by glial cells. TGF-β1 was abnormally upregulated in astrocytes of human ALS and a mouse model for ALS. Administrating TGF-β1 inhibitor slowed disease progression in ALS mice, indicating TGF-β1 as a potential therapeutic target for ALS. In addition, we elucidated a novel role of innate immune adaptor TRIF in eliminating abnormally activated astrocytes through inducing apoptosis.

  4. 筋萎縮性側索硬化症における免疫細胞による活性化グリア細胞抑制機構の解明

    Grant number:26830046  2014.4 - 2017.3

    科学研究費補助金  若手研究(B)

      More details

    Authorship:Principal investigator 

 

Teaching Experience (On-campus) 1

  1. 自然環境と人間

    2020

 

Media Coverage 1

  1. 自然免疫分子に神経保護機能 Newspaper, magazine

    日刊工業新聞  2018.5

     More details

    Author:Other