研究者詳細 - 内田　広夫

論文 - 内田　広夫

分割表示 471 件中 461 - 471 件目／全件表示 >>

Chronopharmacology for deoxyspergualin: toxicity and efficacy in the rat. 査読有り

Uchida H, Kobayashi E, Matsuda K, Mizuta K, Sugimoto K, Kawarasaki H, Hashizume K, Fujimura A

Transplantation 67 巻 ( 9 ) 頁： 1269-74 1999年5月

Chronopharmacology for deoxyspergualin - Toxicity and efficacy in the rat 査読有り

Uchida H, Kobayashi E, Matsuda K, Mizuta K, Sugimoto K, Kawarasaki H, Hashizume K, Fujimura A

TRANSPLANTATION 67 巻 ( 9 ) 頁： 1269 - 1274 1999年5月

Chronopharmacology for deoxyspergualin - Toxicity and efficacy in the rat 査読有り国際誌

H Uchida, E Kobayashi, K Matsuda, K Mizuta, K Sugimoto, H Kawarasaki, K Hashizume, A Fujimura

TRANSPLANTATION 67 巻 ( 9 ) 頁： 1269 - 1274 1999年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS

Background Deoxyspergualin (DSG), a potent immunosuppressive drug, has been clinically used as a rescue therapy for acute graft rejection. However, DSG has severe adverse effects that limits its use. Here, we examined the optimized therapeutic protocol for DSG using chronopharmacological profiles of it.
Methods. First, a dosing time-dependent difference in the toxicity and efficacy of DSG was determined using a heterotopic heart transplantation model. Second, chronokinetics of DSG were examined to reveal the mechanism for dosing time-dependent differences in the effect.
Results. In rats treated with DSG at the active period, bone marrow suppression and damage of small intestine were significantly severe. However, no significant difference was found in cardiac allograft survival and pharmacokinetics according to the timing of drug administration.
Conclusions. The toxicity of DSG varied with the dosing time, whereas its efficacy did not. The chronopharmacological approach may provide merits for immunosuppressive therapy with DSG in clinical organ transplantation.

DOI： 10.1097/00007890-199905150-00012

Web of Science

Scopus

その他リンク： http://orcid.org/0000-0002-1818-6697

Influence of tacrolimus on bile acid and lipid composition in continuously drained bile using a rat model. Comparative study with cyclosporine. 査読有り

Mizuta K, Kobayashi E, Uchida H, Fujimura A, Kawarasaki H, Hashizume K

Transplant international : official journal of the European Society for Organ Transplantation 12 巻 ( 5 ) 頁： 316-22 1999年

Effect of immunosuppressants on bile acid kinetics - Comparative study of cyclosporine with tacrolimus 査読有り国際誌

Mizuta K, Kawarasaki H, Hashizume K, Fujimura A, Uchida H, Kobayashi E

Japanese Pharmacology and Therapeutics 27 巻 ( SUPPL. 7 ) 頁： 93 - 98 1999年

Mechanism of neovascularization in rat newborn organs - Expression of VEGF mRNA and effect of TNP-470 on graft survival 査読有り国際誌

Uchida H, Kobayashi E, Yanagisawa K, Mizuta K, Tominaga S.-I, Hashizume K, Fujimura A

Biotherapy 13 巻 ( 5 ) 頁： 439 - 441 1999年

Survival of rats undergoing continuous bile drainage depends on maintenance of circadian rhythm of bile secretion 査読有り

Mizuta K, Hishikawa S, Yoshida T, Kobayashi E, Uchida H, Fujimura A, Kawarasaki H, Hashizume K

CHRONOBIOLOGY INTERNATIONAL 16 巻 ( 6 ) 頁： 759 - 765 1999年

Experimental small bowel transplantation using newborn intestine in rats - Some immunological studies and considerations for immunological advantage 査読有り

T Yoshida, H Uchida, E Kobayashi, A Fujimura, M Miyata

JAPANESE JOURNAL OF TRANSPLANTATION 34 巻 ( 4 ) 頁： 165 - 173 1999年

Do immunosuppressants directly affect neutrophils, resulting in protection of the liver against ischemia-reperfusion injury? 査読有り

Ohmori M, Kobayashi E, Harada K, Kitoh Y, Mizuta K, Uchida H, Ogino Y, Fujimura A

Transplantation 66 巻 ( 7 ) 頁： 940-1 1998年10月

Dose-dependent reduction of bile secretion in cyclosporine-treated rats. 査読有り

Mizuta K, Kobayashi E, Uchida H, Fujimura A, Kawarasaki H, Hashizume K

Transplantation 65 巻 ( 5 ) 頁： 758-9 1998年3月

Antenatal diagnosis of biliary atresia (type I cyst) at 19 weeks' gestation: differential diagnosis and etiologic implications. 査読有り

Tsuchida Y, Kawarasaki H, Iwanaka T, Uchida H, Nakanishi H, Uno K

Journal of pediatric surgery 30 巻 ( 5 ) 頁： 697-9 1995年5月

　前のページ - 次のページ　

<内田 広夫>

論文 - 内田 広夫

<内田　広夫>

論文 - 内田　広夫