Graduate School of Medicine Professor

Updated on 2022/08/05
博士(医学) ( 2001.3 東京大学 )
pediatric cancer
minimally invasive surgery
medical instrument
pediatric surgery
pediatric surgery
minimally invasive surgery
medical instrument
pediatric cancer
Life Science / General surgery and pediatric surgery
胆道閉鎖症の原因解明
低侵襲手術
pediatric oncology
Nagoya University Nagoya University Hospital Children's Cancer Center
2016.4
Nagoya University Nagoya University Hospital Children's Cancer Center
2016.4
名古屋大学大学院医学系研究科 小児外科学 教授
2013.8
Country:Japan
Nagoya University Graduate School of Medicine
2013.8
Nagoya University Graduate School of Medicine Program in Integrated Medicine Musculoskeletal and Cutaneous Medicine Professor
2013.8
埼玉県立小児医療センター 小児外科 科長
2009.2 - 2013.7
Country:Japan
埼玉県立小児医療センター 小児外科 科長
2009.2 - 2013.7
埼玉県立小児医療センター 小児外科 副部長
2006.4 - 2009.1
Country:Japan
埼玉県立小児医療センター 小児外科 副部長
2006.4 - 2009.1
埼玉県立小児医療センター 小児外科 医長
2003.4 - 2006.3
Country:Japan
埼玉県立小児医療センター 小児外科 医長
2003.4 - 2006.3
獨協医科大学越谷病院 小児外科講師
2001.4 - 2003.3
Country:Japan
Dokkyo Medical University Koshigaya Hospital
2001.4 - 2003.3
自治医科大学一般外科・小児外科助手
1995.7 - 1997.3
Country:Japan
自治医科大学一般外科・小児外科医員
1994.4 - 1995.6
Country:Japan
東京大学医学部附属病院小児外科医員
1993.6 - 1994.3
Country:Japan
財団法人竹田綜合病院 外科医員
1990.12 - 1993.5
Country:Japan
東京大学医学部附属病院第2外科系研修医
1989.6 - 1990.11
Country:Japan
The University of Tokyo Graduate School, Division of Medical Sciences
1997.4 - 2001.3
Country: Japan
The University of Tokyo Graduate School, Division of Medical Sciences
1997.4 - 2001.3
Country: Japan
The University of Tokyo Graduate School, Division of Medical Sciences
1997.4 - 2001.3
Country: Japan
The University of Tokyo Faculty of Medicine
1983.4 - 1989.3
Country: Japan
日本内視鏡外科学会 理事
2020.12
日本小児外科学会 理事
2021.6
日本外科学会 代議員
2014.2
日本内視鏡外科学会
日本小児外科学会 評議員
2009.4
International Pediatric Endosurgery Group
The Pacific Association of Pediatric Surgeons
日本小児血液・がん学会
日本小児泌尿器科学会
日本臨床外科学会
International Pediatric Endosurgery Group
日本臨床外科学会
日本小児血液・がん学会
日本小児泌尿器科学会
日本小児外科学会
日本外科学会
日本内視鏡外科学会
The Pacific Association of Pediatric Surgeons
Histopathologic improvement in biliary cirrhosis after definitive surgery for choledochal cyst. Reviewed
Ishimaru T, Kitano Y, Uchida H, Kawashima H, Gotoh C, Satoh K, Yoshida M, Kishimoto H, Iwanaka T
Journal of pediatric surgery Vol. 45 ( 5 ) page: e11 - 4 2010.5
Growth spurt-related recurrence after Nuss procedure. Reviewed
Ishimaru T, Kitano Y, Uchida H, Kawashima H, Gotoh C, Satoh K, Yoshida M, Sugita A, Iwanaka T
Journal of pediatric surgery Vol. 44 ( 8 ) page: E13 - 6 2009.8
Thoracoscopic posterior tracheopexy during primary esophageal atresia repair ameliorate tracheomalacia in neonates: a single-center retrospective comparative cohort study. Reviewed
Yasui A, Hinoki A, Amano H, Shirota C, Tainaka T, Sumida W, Yokota K, Makita S, Okamoto M, Takimoto A, Nakagawa Y, Uchida H
BMC surgery Vol. 22 ( 1 ) page: 285 2022.7
Patients with gastric volvulus recurrence have high incidence of wandering spleen requiring laparoscopic gastropexy and splenopexy Reviewed
Nakagawa Yoichi, Uchida Hiroo, Amano Hizuru, Hinoki Akinari, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Takada Shunya, Kato Daiki
PEDIATRIC SURGERY INTERNATIONAL 2022.4
Evaluation of minimally invasive surgical skills training: comparing a neonatal esophageal atresia/tracheoesophageal fistula model with a dry box. Reviewed
Deie K, Nakagawa Y, Uchida H, Hinoki A, Shirota C, Tainaka T, Sumida W, Yokota K, Makita S, Fujiogi M, Okamoto M, Takimoto A, Yasui A, Takada S, Maeda T
Surgical endoscopy 2022.3
Utility of endoscopic retrograde cholangiopancreatography in management of pediatric pancreaticobiliary disease Reviewed
Makita Satoshi, Amano Hizuru, Kawashima Hiroki, Hinoki Akinari, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Nakagawa Yoichi, Uchida Hiroo
BMC PEDIATRICS Vol. 22 ( 1 ) page: 134 2022.3
Laparoscopic definitive surgery for congenital biliary dilatation with aggressive hilar bile ductoplasty and complete resection of the intrapancreatic bile duct in pediatric patients is safe and effective, comparable to open surgery Reviewed
Tainaka Takahisa, Shirota Chiyoe, Hinoki Akinari, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Amano Hizuru, Tanaka Yujiro, Uchida Hiroo
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 2022.2
Serum matrix metalloproteinase-7 in biliary atresia: A Japanese multicenter study Reviewed
Sakaguchi Hirotaka, Konishi Ken-ichiro, Yasuda Ryosuke, Sasaki Hideyuki, Yoshimaru Koichiro, Tainaka Takahisa, Fukahori Suguru, Sanada Yukihiro, Iwama Itaru, Shoji Hiromichi, Kinoshita Masahiro, Matsuura Toshiharu, Fujishiro Jun, Uchida Hiroo, Nio Masaki, Yamashita Yushiro, Mizuochi Tatsuki
HEPATOLOGY RESEARCH 2022.2
Safety and feasibility of primary radical surgery for meconium peritonitis considering patients' general condition and perioperative findings Reviewed
Nakagawa Yoichi, Uchida Hiroo, Amano Hizuru, Hinoki Akinari, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Takada Shunya, Maeda Takuya
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 84 ( 1 ) page: 148 - 154 2022.2
Laparoscopic Kasai portoenterostomy can be a standard surgical procedure for treatment of biliary atresia. Reviewed
Shirota C, Hinoki A, Tainaka T, Sumida W, Kinoshita F, Yokota K, Makita S, Amano H, Nakagawa Y, Uchida H
World journal of gastrointestinal surgery Vol. 14 ( 1 ) page: 56 - 63 2022.1
Laparoscopic definitive surgery for choledochal cyst is performed safely and effectively in infants Reviewed
Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Amano Hizuru, Okamoto Masamune, Takimoto Aitaro, Kano Yoko, Yasui Akihiro, Nakagawa Yoichi, Hinoki Akinari, Uchida Hiroo
JOURNAL OF MINIMAL ACCESS SURGERY Vol. 18 ( 3 ) page: 372 - 377 2022
Long-term outcomes of the partial splenectomy for hypersplenism after portoenterostomy of patients with biliary atresia Reviewed
Tainaka Takahisa, Hinoki Akinari, Tanaka Yujiro, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Oshima Kazuo, Amano Hizuru, Takimoto Aitaro, Kano Yoko, Uchida Hiroo
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 83 ( 4 ) page: 765 - 771 2021.11
Shirota C, Tainaka T, Sumida W, Yokota K, Makita S, Amano H, Okamoto M, Takimoto A, Yasui A, Nakagawa Y, Hinoki A, Uchida H
Surgical endoscopy 2021.10
Factors associated with bleeding after endoscopic variceal ligation in children Reviewed
Yokoyama Shinya, Ishizu Yoji, Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ito Takanori, Hinoki Akinari, Sumida Wataru, Shirota Chiyoe, Tainaka Takahisa, Makita Satoshi, Yokota Kazuki, Uchida Hiroo, Fujishiro Mitsuhiro
PEDIATRICS INTERNATIONAL Vol. 63 ( 10 ) page: 1223 - 1229 2021.10
Amano Hizuru, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Tanaka Yujiro, Hinoki Akinari, Kawashima Hiroki, Uchida Hiroo
SURGERY TODAY Vol. 51 ( 9 ) page: 1488 - 1495 2021.9
Sumida Wataru, Tainaka Takahisa, Shirota Chiyoe, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Yasui Akihiro, Okamoto Masamune, Nakagawa Yoichi, Hinoki Akinari, Uchida Hiroo
PEDIATRIC SURGERY INTERNATIONAL 2021.8
Urinary N-1,N-12-diacetylspermine as a biomarker for pediatric cancer: a case-control study Reviewed
Yokota Kazuki, Hinoki Akinari, Hiramatsu Kyoko, Amano Hizuru, Kawamura Machiko, Kuwatsuka Yachiyo, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Nakagawa Yoichi, Uchida Hiroo, Kawakita Masao
PEDIATRIC SURGERY INTERNATIONAL 2021.8
Takeda Masahiro, Sakamoto Seisuke, Uchida Hajime, Shimizu Seiichi, Yanagi Yusuke, Fukuda Akinari, Uchida Hiroo, Yamataka Atsuyuki, Kasahara Mureo
PEDIATRIC SURGERY INTERNATIONAL 2021.8
Kawano Takafumi, Souzaki Ryota, Sumida Wataru, Shimojima Naoki, Hishiki Tomoro, Kinoshita Yoshiaki, Uchida Hiroo, Tajiri Tatsuro, Yoneda Akihiro, Oue Takaharu, Kuroda Tatsuo, Hirobe Seiichi, Koshinaga Tsugumichi, Hiyama Eiso, Nio Masaki, Inomata Yukihiro, Taguchi Tomoaki, Ieiri Satoshi
PEDIATRIC SURGERY INTERNATIONAL 2021.8
Okamoto Masamune, Amano Hizuru, Uchida Hiroo, Hinoki Akinari, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Yasui Akihiro, Nakagawa Yoichi
PEDIATRIC SURGERY INTERNATIONAL 2021.8
Double common bile duct associated with pancreaticobiliary maljunction Reviewed
Yamada Kenta, Ishikawa Takuya, Ohno Eizaburo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Yashika Jun, Yoshikawa Masakatsu, Takami Hideki, Inokawa Yoshikuni, Uchida Hiroo, Kawashima Hiroki, Fujishiro Mitsuhiro
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 83 ( 3 ) page: 655 - 661 2021.8
Development of a novel diagnostic system for bile duct cancer using urinary metabolites. Reviewed
Amano Hizuru, Hinoki Akinari, Uchida Hiroo, Yokota Kazuki, Ishigaki Takashi, Sakairi Minoru, Abe Mayumi, Terui Yasushi, Oda Hirohisa, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Okamoto Masamune, Yasui Akihiro, Nakagawa Yoichi
CANCER RESEARCH Vol. 81 ( 13 ) 2021.7
A patient with very early onset FH-deficient renal cell carcinoma diagnosed at age seven Reviewed
Taniguchi Rieko, Muramatsu Hideki, Okuno Yusuke, Yoshida Taro, Wakamatsu Manabu, Hamada Motoharu, Shirota Chiyoe, Sumida Wataru, Hinoki Akinari, Tainaka Takahisa, Gotoh Yoshimitsu, Tsuzuki Toyonori, Tanaka Yukichi, Kojima Seiji, Uchida Hiroo, Takahashi Yoshiyuki
FAMILIAL CANCER 2021.6
Kawano Takafumi, Souzaki Ryota, Sumida Wataru, Ishimaru Tetsuya, Fujishiro Jun, Hishiki Tomoro, Kinoshita Yoshiaki, Kawashima Hiroshi, Uchida Hiroo, Tajiri Tatsuro, Yoneda Akihiro, Oue Takaharu, Kuroda Tatsuo, Koshinaga Tsugumichi, Hiyama Eiso, Nio Masaki, Inomata Yukihiro, Taguchi Tomoaki, Ieiri Satoshi
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 2021.6
Takimoto Aitaro, Sumida Wataru, Amano Hizuru, Shirota Chiyoe, Tainaka Takahisa, Yokota Kazuki, Makita Satoshi, Yasui Akihiro, Kanou Yoko, Hinoki Akinari, Uchida Hiroo
PEDIATRIC SURGERY INTERNATIONAL Vol. 37 ( 6 ) page: 835 - 835 2021.6
NOVEL BIOMARKER DISCOVERY FOR CHILDHOOD RHABDOMYOSARCOMA USING URINARY METABOLITES Reviewed
Amano Hizuru, Hinoki Akinari, Uchida Hiroo, Yokota Kazuki, Ishigaki Takashi, Sakairi Minoru, Abe Mayumi, Terui Yasushi, Oda Hirohisa, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Kano Yoko, Okamoto Masamune, Yasui Akihiro, Nakagawa Yoichi
PEDIATRIC BLOOD & CANCER Vol. 68 page: S46 - S46 2021.6
Shirota Chiyoe, Kawashima Hiroki, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Amano Hizuru, Takimoto Aitaro, Hinoki Akinari, Uchida Hiroo
SCIENTIFIC REPORTS Vol. 11 ( 1 ) page: 11052 2021.5
A Japanese prospective multicenter study of urinary oxysterols in biliary atresia Reviewed
Konishi Ken-ichiro, Mizuochi Tatsuki, Takei Hajime, Yasuda Ryosuke, Sakaguchi Hirotaka, Ishihara Jun, Takaki Yugo, Kinoshita Masahiro, Hashizume Naoki, Fukahori Suguru, Shoji Hiromichi, Miyano Go, Yoshimaru Koichiro, Matsuura Toshiharu, Sanada Yukihiro, Tainaka Takahisa, Uchida Hiroo, Kubo Yumiko, Tanaka Hiromu, Sasaki Hideyuki, Murai Tsuyoshi, Fujishiro Jun, Yamashita Yushiro, Nio Masaki, Nittono Hiroshi, Kimura Akihiko
SCIENTIFIC REPORTS Vol. 11 ( 1 ) page: 4986 2021.3
Identification of novel neuroblastoma biomarkers in urine samples Reviewed
Yokota Kazuki, Uchida Hiroo, Sakairi Minoru, Abe Mayumi, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Oshima Kazuo, Makita Satoshi, Amano Hizuru, Hinoki Akinari
SCIENTIFIC REPORTS Vol. 11 ( 1 ) page: 4055 2021.2
Risk factors and outcomes of bile leak after laparoscopic surgery for congenital biliary dilatation Reviewed International journal
Tanaka Yujiro, Tainaka Takahisa, Hinoki Akinari, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Oshima Kazuo, Makita Satoshi, Amano Hizuru, Takimoto Aitaro, Kano Yoko, Uchida Hiroo
PEDIATRIC SURGERY INTERNATIONAL Vol. 37 ( 2 ) page: 235 - 240 2021.2
Thoracoscopic surgery for congenital lung cysts: an attempt to limit pulmonary resection in cases of lesions involving multiple lobes Reviewed International journal
Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Amano Hizuru, Hinoki Akinari, Ono Yasuyuki, Uchida Hiroo
PEDIATRIC SURGERY INTERNATIONAL Vol. 37 ( 2 ) page: 213 - 221 2021.2
Usefulness of web search queries for early detection of diseases in infants Reviewed
Yamaguchi Shuji, Hinoki Akinari, Tsubouchi Kota, Amandu Hizuru, Tajima Akira, Uchida Hiroo
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 83 ( 1 ) page: 107 - 111 2021.2
Chiba Kosuke, Tanaka Yujiro, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Oshima Kazuo, Makita Satoshi, Uchida Hiroo
Journal of the Japanese Society of Pediatric Surgeons Vol. 57 ( 1 ) page: 22 - 26 2021
Laparoscopic One-Stage Radical Surgery for Congenital Biliary Dilatation With Biliary Perforation Reviewed
Ishii Hiroki, Makita Satoshi, Yasui Akihiro, Takimoto Aitaro, Yokota Kazuki, Sumida Wataru, Tainaka Takahisa, Shirota Chiyoe, Uchida Hiroo
Journal of the Japanese Society of Pediatric Surgeons Vol. 57 ( 5 ) page: 855 - 859 2021
A Retrospective Study on the Effect of Surgical Experiences of Laparoscopic Kasai Portenterostomy Reviewed
Kurano Yui, Shirota Chiyoe, Hinoki Akinari, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Uchida Hiroo
Journal of the Japanese Society of Pediatric Surgeons Vol. 57 ( 3 ) page: 596 - 599 2021
Oda Hirohisa, Hayashi Yuichiro, Kitasaka Takayuki, Tamada Yudai, Takimoto Aitaro, Hinoki Akinari, Uchida Hiroo, Suzuki Kojiro, Itoh Hayato, Oda Masahiro, Mori Kensaku
MEDICAL IMAGING 2021: COMPUTER-AIDED DIAGNOSIS Vol. 11597 2021
A novel Lugol's iodine staining technique to visualize the upper margin of the surgical anal canal intraoperatively for Hirschsprung disease: a case series Reviewed International journal
Yokota Kazuki, Amano Hizuru, Kudo Toyoki, Yamamura Takeshi, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Nakamura Masanao, Fujishiro Mitsuhiro, Hinoki Akinari, Uchida Hiroo
BMC SURGERY Vol. 20 ( 1 ) 2020.12
URINARY OXYSTEROLS IN BILIARY ATRESIA: A PROSPECTIVE MULTICENTER STUDY IN JAPAN Reviewed
Konishi Ken-ichiro, Mizuochi Tatsuki, Takei Hajime, Yesuda Ryosuke, Sakaguchi Hirotaka, Ishihara Jun, Takaki Yugo, Kinoshita Masahiro, Hashizume Naoki, Fukahori Suguru, Shoji Hiromichi, Miyano Go, Yoshimaru Koichiro, Matsuura Toshiharu, Sanada Yukihiro, Tainaka Takahisa, Uchida Hiroo, Kubo Yumiko, Tanaka Hiromu, Sasaki Hideyuki, Murai Tsuyoshi, Fujishiro Jun, Yamashita Yushiro, Nio Masaki, Nittono Hiroshi, Kimura Akihiko
HEPATOLOGY Vol. 72 page: 224A - 225A 2020.11
Safe diagnostic management of malignant mediastinal tumors in the presence of respiratory distress: a 10-year experience Reviewed International journal
Tanaka Tomoko, Amano Hizuru, Tanaka Yujiro, Takahashi Yoshiyuki, Tajiri Tatsuro, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Tani Yukiko, Hinoki Akinari, Uchida Hiroo
BMC PEDIATRICS Vol. 20 ( 1 ) 2020.6
Clinical characteristics and surgical outcomes of retroperitoneal tumors: a comprehensive data collection from multiple departments Reviewed International journal
Sassa Naoto, Yokoyama Yukihiro, Nishida Yoshihiro, Yamada Suguru, Uchida Hiroo, Kajiyama Hiroaki, Nagino Masato, Kodera Yasuhiro, Gotoh Momokazu
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY Vol. 25 ( 5 ) page: 929 - 936 2020.5
Intestinal flow after anastomotic operations in neonates Reviewed International journal
Ito Yasumasa, Asato Koichiro, Cho Inhyeok, Sakai Yasuhiko, Iwano Koji, Tainaka Takahisa, Uchida Hiroo
COMPUTERS IN BIOLOGY AND MEDICINE Vol. 118 2020.3
Novel zinc alloys for biodegradable surgical staples Reviewed International journal
Amano Hizuru, Miyake Koichi, Hinoki Akinari, Yokota Kazuki, Kinoshita Fumie, Nakazawa Atsuko, Tanaka Yujiro, Seto Yasuhiro, Uchida Hiroo
WORLD JOURNAL OF CLINICAL CASES Vol. 8 ( 3 ) page: 504 - 516 2020.2
術中膵管損傷に対して内視鏡的に膵管ステントを挿入した1例 Reviewed
城田 千代栄, 檜 顕成, 内田 広夫, 田井中 貴久, 住田 亙, 横田 一樹, 牧田 智, 天野 日出, 滝本 愛太朗, 安井 昭洋, 石井 宏樹
日本膵・胆管合流異常研究会プロシーディングス Vol. 43 ( 0 ) page: 84 - 85 2020
小児腹腔鏡手術における肝内胆管形成術 Reviewed
田井中 貴久, 内田 広夫, 城田 千代栄, 住田 亙, 横田 一樹, 牧田 智, 滝本 愛太朗, 安井 昭洋, 石井 宏樹, 檜 顕成
日本膵・胆管合流異常研究会プロシーディングス Vol. 43 ( 0 ) page: 36 - 36 2020
Oda Hirohisa, Nishio Kohei, Kitasaka Takayuki, Amano Hizuru, Takimoto Aitaro, Uchida Hiroo, Suzuki Kojiro, Itoh Hayato, Oda Masahiro, Mori Kensaku
MEDICAL IMAGING 2020: COMPUTER-AIDED DIAGNOSIS Vol. 11314 2020
Identification and Validation of Novel Non-invasive Biomarkers in Patient Urine Samples for Diagnosis of New and Recurrent Neuroblastoma Reviewed International journal
Yokota Kazuki, Uchida Hiroo, Hinoki Akinari, Sakairi Minoru, Abe Mayumi, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Oshima Kazuo, Makita Satoshi, Takimoto Aitaro, Kano Yoko, Inada Kosuke
PEDIATRIC BLOOD & CANCER Vol. 66 page: S106 - S106 2019.12
Biodegradable Surgical Staple Composed of Magnesium Alloy.
Amano H, Hanada K, Hinoki A, Tainaka T, Shirota C, Sumida W, Yokota K, Murase N, Oshima K, Chiba K, Tanaka Y, Uchida H
Scientific reports Vol. 9 ( 1 ) page: 14671 2019.10
Therapeutic strategy for thoracoscopic repair of esophageal atresia and its outcome
Shirota Chiyoe, Tanaka Yujiro, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Oshima Kazuo, Tanaka Tomoko, Tani Yukiko, Uchida Hiroo
PEDIATRIC SURGERY INTERNATIONAL Vol. 35 ( 10 ) page: 1071-1076 2019.10
Efficacy of and prognosis after steroid pulse therapy in patients with poor reduction of jaundice after laparoscopic Kasai portoenterostomy
Tanaka Yujiro, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Oshima Kazuo, Makita Satoshi, Tanaka Tomoko, Tani Yukiko, Chiba Kosuke, Uchida Hiroo
PEDIATRIC SURGERY INTERNATIONAL Vol. 35 ( 10 ) page: 1059-1063 2019.10
NON-INVASIVE SCREENING FOR DETECTING ESOPHAGOGASTRIC VARICES IN CHILDREN WITH BILIARY ATRESIA Reviewed International journal
Yokoyama Shinya, Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ito Takanori, Shirota Chiyoe, Uchida Hiroo, Fujishiro Mitsuhiro
HEPATOLOGY Vol. 70 page: 200A - 200A 2019.10
Laparoscopic Kasai portoenterostomy is advantageous over open Kasai portoenterostomy in subsequent liver transplantation.
Shirota C, Murase N, Tanaka Y, Ogura Y, Nakatochi M, Kamei H, Kurata N, Hinoki A, Tainaka T, Sumida W, Yokota K, Makita S, Oshima K, Uchida H
Surgical endoscopy 2019.9
Spleen stiffness by 2-D shear wave elastography is the most accurate predictor of high-risk esophagogastric varices in children with biliary atresia.
Yokoyama S, Ishigami M, Honda T, Kuzuya T, Ishizu Y, Ito T, Hirooka Y, Tanaka Y, Tainaka T, Shirota C, Chiba K, Uchida H, Fujishiro M
Hepatology research : the official journal of the Japan Society of Hepatology 2019.5
Relationship between Contact Pressure and Motion Artifacts in ECG Measurement with Electrostatic Flocked Electrodes Fabricated on Textile
Takeshita Toshihiro, Yoshida Manabu, Takei Yusuke, Ouchi Atsushi, Hinoki Akinari, Uchida Hiroo, Kobayashi Takeshi
SCIENTIFIC REPORTS Vol. 9 ( 1 ) page: 5897 2019.4
Multicenter, retrospective, comparative study of laparoscopic and open Kasai portoenterostomy in children with biliary atresia from Japanese high-volume centers
Murase Naruhiko, Hinoki Akinari, Shirota Chiyoe, Tomita Hirofumi, Shimojima Naoki, Sasaki Hideyuki, Nio Masaki, Tahara Kazunori, Kanamori Yutaka, Shinkai Masato, Yamamoto Hirotoshi, Sugawara Yasuhiko, Hibi Taizo, Ishimaru Tetsuya, Kawashima Hiroshi, Koga Hiroyuki, Yamataka Atsuyuki, Uchida Hiroo
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES Vol. 26 ( 1 ) page: 43-50 2019.1
静電植毛技術を用いた心電図測定用立体ドライ電極の作製と応用 Reviewed
竹下 俊弘, 吉田 学, 竹井 裕介, 大内 篤, 檜 顕成, 内田 広夫, 小林 健
エレクトロニクス実装学術講演大会講演論文集 Vol. 33 ( 0 ) page: 13A2-01 2019
内視鏡外科手術における熟練医の追体験トレーニングシステムとその評価 Reviewed
安藤 英由樹, 坂井 義治, 小濱 和貴, 内田 広夫, 出家 亨一, 松田 公志, 吉田 健志, 早石 直広
生体医工学 Vol. 57 ( 0 ) page: S198_1 - S198_1 2019
Nuss procedure for patients with pectus excavatum with a history of intrathoracic surgery.
Takanari K, Toriyama K, Kambe M, Nakamura Y, Uchibori T, Ebisawa K, Shirota C, Tainaka T, Uchida H, Kamei Y
Journal of plastic, reconstructive & aesthetic surgery : JPRAS 2018.12
Air test as a simple method of screening for Hirschsprung's disease
Sumida W., Uchida H., Ono Y., Tanaka Y., Tainaka T., Shirota C., Yokota K., Oshima K., Chiba K.
CLINICAL RADIOLOGY Vol. 73 ( 12 ) page: 1041-1045 2018.12
Fujiogi Michimasa, Tanaka Yujiro, Amano Hizuru, Deie Kyoichi, Suzuki Keisuke, Kawashima Hiroshi, Murase Naruhiko, Uchida Hiroo
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 80 ( 4 ) page: 497 - 503 2018.11
Indications for total esophagogastric dissociation in children with gastroesophageal reflux disease
Tanaka Yujiro, Tainaka Takahisa, Uchida Hiroo
SURGERY TODAY Vol. 48 ( 11 ) page: 971-977 2018.11
Laparoscopically Assisted Anorectoplasty for Intermediate-Type Imperforate Anus: Comparison of Surgical Outcomes with the Sacroperineal Approach
Ishimaru Tetsuya, Kawashima Hiroshi, Tainaka Takahisa, Suzuki Keisuke, Takami Shohei, Kakihara Tomo, Katoh Reiko, Aoyama Tomohiro, Uchida Hiroo, Iwanaka Tadashi
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES 2018.10
Single-stage laparoscopic transanal pull-through modified Swenson procedure without leaving a muscular cuff for short- and long-type Hirschsprung disease: a comparative study
Yokota Kazuki, Uchida Hiroo, Tainaka Takahisa, Tanaka Yujiro, Shirota Chiyoe, Hinoki Akinari, Kato Takazumi, Sumida Wataru, Oshima Kazuo, Chiba Kosuke, Ishimaru Tetsuya, Kawashima Hiroshi
PEDIATRIC SURGERY INTERNATIONAL Vol. 34 ( 10 ) page: 1105-1110 2018.10
The impact of body weight on stapled anastomosis in pediatric patients
Amano Hizuru, Tanaka Yujiro, Tainaka Takahisa, Hinoki Akinari, Kawashima Hiroshi, Kakihara Tomo, Morita Kaori, Uchida Hiroo
JOURNAL OF PEDIATRIC SURGERY Vol. 53 ( 10 ) page: 2036-2040 2018.10
Oral administration of eicosapentaenoic acid suppresses liver fibrosis in postoperative patients with biliary atresia
Sumida Wataru, Uchida Hiroo, Tainaka Takahisa, Shirota Chiyoe, Hinoki Akinari, Kato Takazumi, Yokota Kazuki, Oshima Kazuo, Shirotuki Ryo, Chiba Kosuke, Tanaka Yujiro
PEDIATRIC SURGERY INTERNATIONAL Vol. 34 ( 10 ) page: 1059-1063 2018.10
Long-term outcomes and complications after laparoscopic-assisted anorectoplasty vs. posterior sagittal anorectoplasty for high- and intermediate-type anorectal malformation. Reviewed International journal
Takahisa Tainaka, Hiroo Uchida, Yujiro Tanaka, Akinari Hinoki, Chiyoe Shirota, Wataru Sumida, Kazuki Yokota, Satoshi Makita, Kazuo Oshima, Kosuke Chiba, Tetsuya Ishimaru, Hiroshi Kawashima
Pediatric surgery international Vol. 34 ( 10 ) page: 1111 - 1115 2018.10
Investigation of the feasibility and safety of single-stage anorectoplasty in neonates with anovestibular fistula. Reviewed International journal
Chiyoe Shirota, Keisuke Suzuki, Hiroo Uchida, Hiroshi Kawashima, Akinari Hinoki, Takahisa Tainaka, Wataru Sumida, Naruhiko Murase, Kazuo Oshima, Kosuke Chiba, Satoshi Makita, Yujiro Tanaka
Pediatric surgery international Vol. 34 ( 10 ) page: 1117 - 1120 2018.10
Introduction of resection of intrahepatic bile duct stenosis-causing membrane or septum into laparoscopic choledochal cyst excision
Tanaka Yujiro, Tainaka Takahisa, Sumida Wataru, Hinoki Akinari, Shirota Chiyoe, Murase Naruhiko, Oshima Kazuo, Shirotsuki Ryo, Chiba Kosuke, Uchida Hiroo
PEDIATRIC SURGERY INTERNATIONAL Vol. 34 ( 10 ) page: 1087-1092 2018.10
BESNet: Boundary-enhanced Segmentation of Cells in Histopathological Images
Hirohisa Oda, Holger Roth, Kosuke Chiba, Jure Sokolic, Takayuki Kitasaka, Masahiro Oda, Akinari Hinoki, Hiroo Uchida, Julia A Schnabel, Kensaku Mori
MICCAI 2018, LNCS 11071 page: 228-236 2018.9
Automated ganglion cell detection using fully convolutional networks and evaluation under different training losses
Hirohisa Oda, Kosuke Chiba, Holger R. Roth, Takayuki Kitasaka, Masahiro Oda, Akinari Hinoki, Hiroo Uchida, Kensaku Mori
International Journal of Computer Assisted Radiology and Surgery Vol. 13 ( 1 ) page: s104-106 2018.6
Novel thoracoscopic navigation surgery for neonatal chylothorax using indocyanine-green fluorescent lymphography. Reviewed International journal
Ryo Shirotsuki, Hiroo Uchida, Yujiro Tanaka, Chiyoe Shirota, Kazuki Yokota, Naruhiko Murase, Akinari Hinoki, Kazuo Oshima, Kosuke Chiba, Wataru Sumida, Masahiro Hayakawa, Takahisa Tainaka
Journal of pediatric surgery Vol. 53 ( 6 ) page: 1246 - 1249 2018.6
特集 小児外科における消化器内視鏡外科手術 胆道閉鎖症に対する腹腔鏡下肝門部空腸吻合術 Reviewed
内田 広夫, 田中 裕次郎, 田井中 貴久, 城田 千代栄, 住田 亙, 村瀬 成彦
手術 Vol. 72 ( 6 ) page: 861 - 870 2018.5
Clinical, Pathologic, and Genetic Features of Neonatal Dubin-Johnson Syndrome: A Multicenter Study in Japan
Togawa Takao, Mizuochi Tatsuki, Sugiura Tokio, Kusano Hironori, Tanikawa Ken, Sasaki Takato, Ichinose Fumio, Kagimoto Seiichi, Tainaka Takahisa, Uchida Hiroo, Saitoh Shinji
JOURNAL OF PEDIATRICS Vol. 196 page: 161-+ 2018.5
Evaluation of Surgical Devices Using an Artificial Pediatric Thoracic Model: A Comparison Between Robot-Assisted Thoracoscopic Suturing Versus Conventional Video-Assisted Thoracoscopic Suturing
Takazawa Shinya, Ishimaru Tetsuya, Harada Kanako, Deie Kyoichi, Hinoki Akinari, Uchida Hiroo, Sugita Naohiko, Mitsuishi Mamoru, Iwanaka Tadashi, Fujishiro Jun
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES Vol. 28 ( 5 ) page: 622-627 2018.5
Usefulness of fetal magnetic resonance imaging for postnatal management of congenital lung cysts: prediction of probability for emergency surgery
Shirota Chiyoe, Tainaka Takahisa, Nakane Toshiki, Tanaka Yujiro, Hinoki Akinari, Sumida Wataru, Murase Naruhiko, Oshima Kazuo, Chiba Kosuke, Shirotsuki Ryo, Uchida Hiroo
BMC PEDIATRICS Vol. 18 ( 1 ) page: 105 2018.3
Fabrication of Multi-lead ECG measurement wear using electrostatic flocking technology Reviewed
Proceedings of JIEP Annual Meeting Vol. 32 ( 0 ) page: 179 - 180 2018
Idiopathic Omental Torsion Relieved With Conservative Management Reviewed
Yokota Kazuki, Chiba Kosuke, Uchida Hiroo, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Hinoki Akinari, Sumida Wataru, Kato Takazumi, Oshima Kazuo
Journal of the Japanese Society of Pediatric Surgeons Vol. 54 ( 2 ) page: 302 - 306 2018
BESNet: Boundary-Enhanced Segmentation of Cells in Histopathological Images Reviewed
Oda Hirohisa, Roth Holger R., Chiba Kosuke, Sokolic Jure, Kitasaka Takayuki, Oda Masahiro, Hinoki Akinari, Uchida Hiroo, Schnabel Julia A., Mori Kensaku
MEDICAL IMAGE COMPUTING AND COMPUTER ASSISTED INTERVENTION - MICCAI 2018, PT II Vol. 11071 page: 228 - 236 2018
The efficacy of resection of intrahepatic bile duct stenosis-causing membrane or septum for preventing hepatolithiasis after choledochal cyst excision. Reviewed
Tanaka Y, Tainaka T, Sumida W, Shirota C, Hinoki A, Murase N, Oshima K, Shirotsuki R, Chiba K, Uchida H
Journal of pediatric surgery Vol. 52 ( 12 ) page: 1930-1933 2017.12
Intralobar pulmonary sequestration expanding toward the contralateral thorax: two case reports. Reviewed
Amano H, Fujishiro J, Hinoki A, Uchida H
BMC surgery Vol. 17 ( 1 ) page: 110 2017.11
Excellent prognosis of patients with intermediate-risk neuroblastoma and residual tumor postchemotherapy. Reviewed
Amano H, Uchida H, Tanaka Y, Tainaka T, Mori M, Oguma E, Kishimoto H, Kawashima H, Arakawa Y, Hanada R, Koh K
Journal of pediatric surgery 2017.11
Mesh hiatal reinforcement in laparoscopic Nissen fundoplication for neurologically impaired children is safe and feasible. Reviewed
Amano H, Tanaka Y, Kawashima H, Deie K, Suzuki K, Fujiogi M, Morita K, Iwanaka T, Uchida H
Nagoya journal of medical science Vol. 79 ( 4 ) page: 427-433 2017.11
Comparison of outcomes of thoracoscopic primary repair of gross type C esophageal atresia performed by qualified and non-qualified surgeons. Reviewed
Tanaka Y, Tainaka T, Sumida W, Shirota C, Murase N, Oshima K, Shirotsuki R, Chiba K, Uchida H
Pediatric surgery international Vol. 33 ( 10 ) page: 1081-1086 2017.10
A Novel Laparoscopic Surgery Model with a Device to Expand the Abdominal Working Space in Rats: The Influence of Pneumoperitoneum and Skin Incision Length on Postoperative Inflammatory Cytokines. Reviewed
Murase N, Tainaka T, Uchida H, Hinoki A, Shirota C, Yokota K, Oshima K, Shirotsuki R, Chiba K, Tanaka Y
Journal of investigative surgery : the official journal of the Academy of Surgical Research page: 1-6 2017.9
Review of redo-Kasai portoenterostomy for biliary atresia in the transition to the liver transplantation era. Reviewed
Sumida W, Uchida H, Tanaka Y, Tainaka T, Shirota C, Murase N, Oshima K, Shirotsuki R, Chiba K
Nagoya journal of medical science Vol. 79 ( 3 ) page: 415-420 2017.8
Comparison of single-incision laparoscopic percutaneous extraperitoneal closure (SILPEC) and open repair for pediatric inguinal hernia: a single-center retrospective cohort study of 2028 cases. Reviewed
Amano H, Tanaka Y, Kawashima H, Deie K, Fujiogi M, Suzuki K, Morita K, Iwanaka T, Uchida H
Surgical endoscopy 2017.6
New Navigation Surgery for Resection of Lymphatic Malformations Using Indocyanine Green Fluorescence Imaging. Reviewed
Shirota C, Hinoki A, Takahashi M, Tanaka Y, Tainaka T, Sumida W, Murase N, Oshima K, Shirotsuki R, Chiba K, Morimoto Y, Uchida H
The American journal of case reports Vol. 18 page: 529-531 2017.5
New Navigation Surgery for Resection of Lymphatic Malformations Using Indocyanine Green Fluorescence Imaging
Shirota Chiyoe, Hinoki Akinari, Takahashi Masataka, Tanaka Yujiro, Tainaka Takahisa, Sumida Wataru, Murase Naruhiko, Oshima Kazuo, Shirotsuki Ryo, Chiba Kosuke, Morimoto Yuji, Uchida Hiroo
AMERICAN JOURNAL OF CASE REPORTS Vol. 18 2017.5
Laparoscopic resection of neuroblastomas in low- to high-risk patients without image-defined risk factors is safe and feasible. Reviewed
Shirota C, Tainaka T, Uchida H, Hinoki A, Chiba K, Tanaka Y
BMC pediatrics Vol. 17 ( 1 ) page: 71 2017.3
Two-Stage Thoracoscopic Repair of Long-Gap Esophageal Atresia Using Internal Traction Is Safe and Feasible. Reviewed
Tainaka T, Uchida H, Tanano A, Shirota C, Hinoki A, Murase N, Yokota K, Oshima K, Shirotsuki R, Chiba K, Amano H, Kawashima H, Tanaka Y
Journal of laparoendoscopic & advanced surgical techniques. Part A Vol. 27 ( 1 ) page: 71-75 2017.1
Pure Laparoscopic Partial Hepatectomy for Hepatoblastoma in an Infant: A Case Report Reviewed
Amano Hizuru, Kawashima Hiroshi, Tanaka Yujiro, Deie Kyoichi, Fujiogi Michimasa, Suzuki Keisuke, Morita Kaori, Iwanaka Tadashi, Uchida Hiroo
Journal of the Japanese Society of Pediatric Surgeons Vol. 53 ( 5 ) page: 1073 - 1078 2017
Large retroperitoneal immature teratoma leading to renovascular hypertension. Reviewed
Tainaka T, Ono Y, Yamada Y, Mutoh D, Uchida H
Pediatrics international : official journal of the Japan Pediatric Society Vol. 58 ( 12 ) page: 1363-1364 2016.12
Comparing surgical outcomes of complete thoracoscopic lobectomy for congenital cystic lung disease between neonatal and infantile patients. Reviewed
Tainaka T, Uchida H, Tanaka Y, Shirota C, Yokota K, Murase N, Oshima K, Shirotsuki R, Chiba K, Hinoki A
Nagoya journal of medical science Vol. 78 ( 4 ) page: 447-454 2016.12
Risk factors for thoracic and spinal deformities following lung resection in neonates, infants, and children. Reviewed
Makita S, Kaneko K, Ono Y, Uchida H
Surgery today 2016.10
Neonatal Cholestasis in East-Asian patients with Dubin-Johnson Syndrome: Clinical, Pathological and Genetic Features Reviewed International journal
Takao Togawa, Tokio Sugiura, Tatsuki Mizuochi, Hironori Kusano, Ken Tanikawa, Takahisa Tainaka, Hiroo Uchida, Tomoko Hara, Ryusuke Nambu, Seiichi Kagimoto, Shinji Saitoh
HEPATOLOGY Vol. 64 page: 278A - 278A 2016.10
Classification of biliary atresia in the laparoscopic era. Reviewed
Nakamura H, Murase N, Koga H, Cazares J, Lane GJ, Uchida H, Yamataka A
Pediatric surgery international 2016.9
More than one-third of successfully nonoperatively treated patients with complicated appendicitis experienced recurrent appendicitis: Is interval appendectomy necessary? Reviewed
Tanaka Y, Uchida H, Kawashima H, Fujiogi M, Suzuki K, Takazawa S, Deie K, Amano H, Iwanaka T
Journal of pediatric surgery 2016.9
Long-term outcomes after revision of Kasai portoenterostomy for biliary atresia. Reviewed
Shirota C, Uchida H, Ono Y, Murase N, Tainaka T, Yokota K, Oshima K, Shirotsuki R, Hinoki A, Ando H
Journal of hepato-biliary-pancreatic sciences 2016.9
Steroid pulse therapy prevents restenosis following balloon dilatation for esophageal stricture. Reviewed
Yokota K, Uchida H, Tanano A, Shirota C, Tainaka T, Hinoki A, Murase N, Oshima K, Shirotsuki R, Chiba K
Pediatric surgery international Vol. 32 ( 9 ) page: 875-9 2016.9
Contraindications and image-defined risk factors in laparoscopic resection of abdominal neuroblastoma. Reviewed
Tanaka Y, Kawashima H, Mori M, Fujiogi M, Suzuki K, Amano H, Morita K, Arakawa Y, Koh K, Oguma E, Iwanaka T, Uchida H
Pediatric surgery international Vol. 32 ( 9 ) page: 845-50 2016.9
Laparoscopic side-to-side pancreaticojejunostomy for chronic pancreatitis in children. Reviewed
Deie K, Uchida H, Kawashima H, Tanaka Y, Fujiogi M, Amano H, Murase N, Tainaka T
Journal of minimal access surgery 2016.5
Left thoracoscopic two-stage repair of tracheoesophageal fistula with a right aortic arch and a vascular ring. Reviewed
Oshima K, Uchida H, Tainaka T, Tanano A, Shirota C, Yokota K, Murase N, Shirotsuki R, Chiba K, Hinoki A
Journal of minimal access surgery 2016.5
Cytomegalovirus (CMV) Monitoring After Liver Transplantation: Comparison of CMV Pp65 Antigenemia Assay with Real-Time PCR Calibrated to WHO International Standard. Reviewed
Kamei H, Ito Y, Onishi Y, Suzuki M, Imai H, Kurata N, Hori T, Tainaka T, Uchida H, Ogura Y
Annals of transplantation Vol. 21 page: 131-6 2016.3
A feasibility of single-incision laparoscopic percutaneous extraperitoneal closure for treatment of incarcerated inguinal hernia in children: our preliminary outcome and review of the literature. Reviewed
Murase N, Uchida H, Seki T, Hiramatsu K
Nagoya journal of medical science Vol. 78 ( 1 ) page: 19-25 2016.2
Naruhiko Murase, Hiroo Uchida, Takashi Seki, Kiyoshi Hiramatsu
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 78 ( 1 ) page: 19 - 25 2016.2
Operative procedures of single-incision laparoscopic repair of pediatric epigastric hernia have become simple and feasible with the use of a novel suture-assisting needle Reviewed International journal
Kyoichi Deie, Hiroo Uchida, Hiroshi Kawashima, Yujiro Tanaka, Hizuru Amano, Naruhiko Murase, Takahisa Tainaka
Journal of Pediatric Surgery Case Reports Vol. 4 page: 22 - 26 2016.1
Makita Satoshi, Uchida Hiroo
Journal of the Japanese Society of Pediatric Surgeons Vol. 52 ( 6 ) page: 1251 - 1255 2016
Laparoscopic-assisted pancreaticoduodenectomy in a child with gastrinoma. Reviewed
Murase N, Uchida H, Tainaka T, Kawashima H, Tanaka Y, Amano H, Kishimoto H
Pediatrics international : official journal of the Japan Pediatric Society Vol. 57 ( 6 ) page: 1196-8 2015.12
Emergency hepatectomy for hepatic arteriovenous malformation combined with pulmonary hypertension in an infant Reviewed International journal
Naruhiko Murase, Hiroo Uchida, Akihide Tanano, Chiyoe Shirota, Akinari Hinoki, Takahisa Tainaka, Kazuki Yokota, Kazuo Oshima, Ryo Shirotsuki
Journal of Pediatric Surgery Case Reports Vol. 3 ( 12 ) page: 534 - 536 2015.12
Pediatric Surgery. Reviewed
Iwanaka T, Yamataka A, Uemura S, Okuyama H, Segawa O, Nio M, Yoshizawa J, Yagi M, Ieiri S, Uchida H, Koga H, Sato M, Soh H, Take H, Hirose R, Fukuzawa H, Mizuno M, Watanabe T
Asian journal of endoscopic surgery Vol. 8 ( 4 ) page: 390-407 2015.11
An Easy and Safe Technique for Laparoscopic Pyloromyotomy: Using a Vascular Clamp for Stabilization of the Pylorus. Reviewed
Fujiogi M, Tanaka Y, Kawashima H, Toma M, Suzuki K, Amano H, Morita K, Uchida H, Iwanaka T
Journal of laparoendoscopic & advanced surgical techniques. Part A 2015.8
Influence of surgical intervention on neurodevelopmental outcome in infants with focal intestinal perforation. Reviewed
Tanaka Y, Uchida H, Kawashima H, Sato K, Takazawa S, Deie K, Masuko T, Kanno K, Shimizu M
Pediatrics international : official journal of the Japan Pediatric Society Vol. 57 ( 4 ) page: 687-9 2015.8
Accessory scrotum with perineal lipoma diagnosed prenatally: case report and review of the literature. Reviewed
Murase N, Uchida H, Hiramatsu K
Nagoya journal of medical science Vol. 77 ( 3 ) page: 501-6 2015.8
A new modification of laparoscopic percutaneous extraperitoneal closure procedure for repairing pediatric femoral hernias involving a special needle and a wire loop. Reviewed
Tainaka T, Uchida H, Ono Y, Tanano A, Shirota C, Yokota K, Murase N, Makita S, Shirotsuki R
Nagoya journal of medical science Vol. 77 ( 3 ) page: 531-5 2015.8
Naruhiko Murase, Hiroo Uchida, Kiyoshi Hiramatsu
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 77 ( 3 ) page: 501 - 506 2015.8
Takahisa Tainaka, Hiroo Uchida, Yasuyuki Ono, Akihide Tanano, Chiyoe Shirota, Kazuki Yokota, Naruhiko Murase, Satoshi Makita, Ryo Shirotsuki
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 77 ( 3 ) page: 531 - 535 2015.8
Long-term outcomes of operative versus nonoperative treatment for uncomplicated appendicitis. Reviewed
Tanaka Y, Uchida H, Kawashima H, Fujiogi M, Takazawa S, Deie K, Amano H
Journal of pediatric surgery 2015.7
Prophylactic effect of H2 blocker for anastomotic stricture after esophageal atresia repair. Reviewed
Murase N, Uchida H, Kaneko K, Ono Y, Makita S, Yokota K
Pediatrics international : official journal of the Japan Pediatric Society Vol. 57 ( 3 ) page: 461-4 2015.6
Current Practice and Outcomes of Thoracoscopic Esophageal Atresia and Tracheoesophageal Fistula Repair: A Multi-institutional Analysis in Japan. Reviewed
Okuyama H, Koga H, Ishimaru T, Kawashima H, Yamataka A, Urushihara N, Segawa O, Uchida H, Iwanaka T
Journal of laparoendoscopic & advanced surgical techniques. Part A Vol. 25 ( 5 ) page: 441-4 2015.5
Effectiveness and safety of immunization with live-attenuated and inactivated vaccines for pediatric liver transplantation recipients. Reviewed
Kawano Y, Suzuki M, Kawada J, Kimura H, Kamei H, Ohnishi Y, Ono Y, Uchida H, Ogura Y, Ito Y
Vaccine Vol. 33 ( 12 ) page: 1440-5 2015.3
Laparoscopic ligation of varicocele testis in children:TANKO operation Reviewed
Vol. 69 ( 2 ) page: 179 - 185 2015.2
Laparoscopic partial gastrectomy of a huge gastric duplication cyst in an infant. Reviewed
Takazawa S, Uchida H, Kawashima H, Tanaka Y, Sato K, Jimbo T, Iwanaka T
Nagoya journal of medical science Vol. 77 ( 1-2 ) page: 291-6 2015.2
LAPAROSCOPIC PARTIAL GASTRECTOMY OF A HUGE GASTRIC DUPLICATION CYST IN AN INFANT Reviewed
Shinya Takazawa, Hiroo Uchida, Hiroshi Kawashima, Yujiro Tanaka, Kaori Sato, Takahiro Jimbo, Tadashi Iwanaka
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 77 ( 1-2 ) page: 291 - 296 2015.2
The umbilical Benz incision for reduced port surgery in pediatric patients. Reviewed
Amano H, Uchida H, Kawashima H, Deie K, Murase N, Makita S, Yokota K, Tanaka Y
JSLS : Journal of the Society of Laparoendoscopic Surgeons / Society of Laparoendoscopic Surgeons Vol. 19 ( 1 ) page: e2014.00238 2015.1
Initial treatment of septated parapneumonic empyema with drainage plus fibrinolytic agents is equally effective as video-assisted thoracoscopic surgery, and is suitable as first-line therapy. Reviewed
Shirota C, Uchida H
Translational pediatrics Vol. 4 ( 1 ) page: 41-4 2015.1
MURASE Naruhiko, UCHIDA Hiroo, HIRAMATSU Kiyoshi, AMEMIYA Takeshi, SEKI Takashi, ARAI Toshiyuki
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) Vol. 76 ( 3 ) page: 529 - 533 2015
A New Era of Laparoscopic Revision of Kasai Portoenterostomy for the Treatment of Biliary Atresia. Reviewed
Murase N, Uchida H, Ono Y, Tainaka T, Yokota K, Tanano A, Shirota C, Shirotsuki R
BioMed research international Vol. 2015 page: 173014 2015
Laparoscopic ligation of varicocele testis in children: Tanko operation Reviewed International journal
Kawashima H, Tada M, Sato A, Hori Y, Funakoshi D, Uchida H
Japanese Journal of Clinical Urology Vol. 69 ( 2 ) page: 179 - 185 2015
Laparoscopic partial nephrectomy for the treatment of large cystic nephroma in children. Reviewed
Tanaka Y, Uchida H, Kawashima H, Masuko T, Takazawa S, Deie K, Amano H, Iwanaka T
Journal of laparoendoscopic & advanced surgical techniques. Part A Vol. 24 ( 12 ) page: 901-6 2014.12
Surgical complications, especially gastroesophageal reflux disease, intestinal adhesion obstruction, and diaphragmatic hernia recurrence, are major sequelae in survivors of congenital diaphragmatic hernia. Reviewed
Yokota K, Uchida H, Kaneko K, Ono Y, Murase N, Makita S, Hayakawa M
Pediatric surgery international Vol. 30 ( 9 ) page: 895-9 2014.9
Urethroscopic holmium: YAG laser ablation for acquired posterior urethral diverticulum after repair of anorectal malformations. Reviewed
Takazawa S, Uchida H, Kawashima H, Tanaka Y, Masuko T, Deie K, Amano H, Kobayashi K, Tada M, Iwanaka T
Pediatric surgery international Vol. 30 ( 9 ) page: 945-9 2014.9
Full-thickness small intestine necrosis with midgut volvulus, distributed in a patchy fashion, is reversible with moderate blood flow: resumption of normal function to non-viable intestine. Reviewed
Amano H, Uchida H, Kawashima H, Tanaka Y, Kishimoto H
Nagoya journal of medical science Vol. 76 ( 3-4 ) page: 375-80 2014.8
Massive hemorrhage after Kasai portoenterostomy in a patient with a congenital extrahepatic portosystemic shunt, malrotation and a double aortic arch: report of a case. Reviewed
Takazawa S, Uchida H, Kawashima H, Tanaka Y, Sato K, Jimbo T, Deie K, Koiwai K, Nomura K, Iwanaka T
Surgery today Vol. 44 ( 8 ) page: 1561-4 2014.8
Hizuru Amano, Hiroo Uchida, Hiroshi Kawashima, Yujiro Tanaka, Hiroshi Kishimoto
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 76 ( 3-4 ) page: 375 - 380 2014.8
OP-052-7 当施設における小児膵SPT(Solid pseudopapillary tumor)の治療経験(OP-052 膵 IPMN・その他,一般演題,第114回日本外科学会定期学術集会) Reviewed
牧田 智, 金子 健一朗, 小野 靖之, 横田 一樹, 村瀬 成彦, 内田 広夫
日本外科学会雑誌 Vol. 115 ( 2 ) page: 408 2014.3
Thoracoscopic Resection of an Intralobar Pulmonary Sequestration in a Neonate With Heart Failure Reviewed
Murase Naruhiko, Kaneko Kenichiro, Ono Yasuyuki, Yokota Kazuki, Makita Satoshi, Uchida Hiroo
Journal of the Japanese Society of Pediatric Surgeons Vol. 50 ( 5 ) page: 946 - 949 2014
Multicenter retrospective comparative study of laparoscopically assisted and conventional anorectoplasty for male infants with rectoprostatic urethral fistula Reviewed
Yamataka Atsuyuki, Morikawa Yasuhide, Yagi Makoto, Kimura Osamu, Kuroda Tatsuo, Ueno Shigeru, Iwanaka Tadashi, Iwai Jun, Zaizen Yoshio, Koga Hiroyuki, Shimono Ryuichi, Yagi Makoto, Kimura Osamu, Kubota Masayuki, Murase Naruhiko, Kanamori Yutaka, Tanaka Hideaki, Takahashi Masataka, Ikeda Taro, Kubota Akio, Nara Keigo, Satoh Kaori, Amano Hizuru, Takazawa Shinya, Tanaka Yujiro, Uchida Hiroo, Kawashima Hiroshi, Jimbo Takahiro, Fukumoto Kohji, Ueno Shigeru, Ishimaru Tetsuya
JOURNAL OF PEDIATRIC SURGERY Vol. 48 ( 12 ) page: 2383-2388 2013.12
Laparoscopic excision of urachal remnants is a safe and effective alternative to open surgery in children. Reviewed
Masuko T, Uchida H, Kawashima H, Tanaka Y, Deie K, Iwanaka T
Journal of laparoendoscopic & advanced surgical techniques. Part A Vol. 23 ( 12 ) page: 1016-9 2013.12
External stabilization for severe tracheobronchomalacia using separated ring-reinforced ePTFE grafts is effective and safe on a long-term basis. Reviewed
Takazawa S, Uchida H, Kawashima H, Tanaka Y, Masuko T, Deie K, Nagase Y, Iwanaka T
Pediatric surgery international Vol. 29 ( 11 ) page: 1165-9 2013.11
Single-incision laparoscopic-assisted appendectomy in children: exteriorization of the appendix is a key component of a simple and cost-effective surgical technique. Reviewed
Deie K, Uchida H, Kawashima H, Tanaka Y, Masuko T, Takazawa S
Pediatric surgery international Vol. 29 ( 11 ) page: 1187-91 2013.11
Complete thoracoscopic versus video-assisted thoracoscopic resection of congenital lung lesions. Reviewed
Tanaka Y, Uchida H, Kawashima H, Sato K, Takazawa S, Masuko T, Deie K, Iwanaka T
Journal of laparoendoscopic & advanced surgical techniques. Part A Vol. 23 ( 8 ) page: 719-22 2013.8
Successful two-stage thoracoscopic repair of long-gap esophageal atresia using simple internal traction and delayed primary anastomosis in a neonate: report of a case. Reviewed
Tanaka Y, Uchida H, Kawashima H, Sato K, Takazawa S, Jimbo T, Iwanaka T
Surgery today Vol. 43 ( 8 ) page: 906-9 2013.8
Development of a needle driver with multiple degrees of freedom for neonatal laparoscopic surgery. Reviewed
Ishimaru T, Takazawa S, Uchida H, Kawashima H, Fujii M, Harada K, Sugita N, Mitsuishi M, Iwanaka T
Journal of laparoendoscopic & advanced surgical techniques. Part A Vol. 23 ( 7 ) page: 644-8 2013.7
Long-term survivor of relapsed stage IV malignant rhabdoid tumor of the kidney Reviewed
Kato Motohiro, Koh Katsuyoshi, Oshima Koichi, Oguma Eiji, Uchida Hiroo, Kishimoto Hiroshi, Kikuchi Akira, Hanada Ryoji
PEDIATRICS INTERNATIONAL Vol. 55 ( 2 ) page: 245-248 2013.4
Long-term survivor of relapsed stage IV malignant rhabdoid tumor of the kidney. Reviewed
Kato M, Koh K, Oshima K, Oguma E, Uchida H, Kishimoto H, Kikuchi A, Hanada R
Pediatrics international : official journal of the Japan Pediatric Society Vol. 55 ( 2 ) page: 245-8 2013.4
Sacrococcygeal yolk sac tumor developing after teratoma: a clinicopathological study of pediatric sacrococcygeal germ cell tumors and a proposal of the pathogenesis of sacrococcygeal yolk sac tumors. Reviewed
Yoshida M, Matsuoka K, Nakazawa A, Yoshida M, Inoue T, Kishimoto H, Nakayama M, Takaba E, Hamazaki M, Yokoyama S, Horie H, Tanaka M, Gomi K, Ohama Y, Kigasawa H, Kitano Y, Uchida H, Kanamori Y, Iwanaka T, Tanaka Y
Journal of pediatric surgery Vol. 48 ( 4 ) page: 776-81 2013.4
Minimally invasive surgery for pediatric cases of large extraovarian teratoma with considerable solid component Reviewed International journal
Shinya Takazawa, Hiroo Uchida, Hiroshi Kawashima, Yujiro Tanaka, Kaori Sato, Takahiro Jimbo, Takayuki Masuko, Kyoichi Deie, Tadashi Iwanaka
Journal of Pediatric Surgery Case Reports Vol. 1 ( 8 ) page: 226 - 229 2013
Stapled intestinal anastomosis is a simple and reliable method for management of intestinal caliber discrepancy in children. Reviewed
Sato K, Uchida H, Tanaka Y, Takazawa S, Jimbo T, Deie K
Pediatric surgery international Vol. 28 ( 9 ) page: 893-8 2012.9
Differences in the characteristics and management of pyriform sinus fistula between neonates and young children. Reviewed
Amano H, Uchida H, Sato K, Kawashima H, Tanaka Y, Takazawa S, Jimbo T
Pediatric surgery international Vol. 28 ( 1 ) page: 15-20 2012.1
Sialolipoma of the submandibular gland in a child. Reviewed
Sato K, Gotoh C, Uchida H, Kawashima H, Yoshida M, Kitano Y, Kishimoto H
Journal of pediatric surgery Vol. 46 ( 2 ) page: 408-10 2011.2
Inguinal hernia repair in children using single-incision laparoscopic-assisted percutaneous extraperitoneal closure. Reviewed
Uchida H, Kawashima H, Goto C, Sato K, Yoshida M, Takazawa S, Iwanaka T
Journal of pediatric surgery Vol. 45 ( 12 ) page: 2386-9 2010.12
Laparoscopic spleen-preserving distal pancreatectomy for solid pseudopapillary tumor with conservation of splenic vessels in a child. Reviewed
Uchida H, Goto C, Kishimoto H, Kawashima H, Sato K, Yoshida M, Takazawa S
Journal of pediatric surgery Vol. 45 ( 7 ) page: 1525-9 2010.7
Recurrence of a congenital pancreatic cyst mimicking omental cyst after laparoscopic cyst resection. Reviewed
Ishimaru T, Uchida H, Yotsumoto K, Gotoh C, Yoshida M, Oguma E, Kishimoto H, Iwanaka T, Kitano Y
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie Vol. 19 ( 1 ) page: 53-4 2009.2
Residual fistula after laparoscopically assisted anorectoplasty: is it a rare problem? Reviewed
Uchida H, Iwanaka T, Kitano Y, Kudou S, Ishimaru T, Yotsumoto K, Gotoh C, Yoshida M
Journal of pediatric surgery Vol. 44 ( 1 ) page: 278-81 2009.1
Seminal vesicle abscesses associated with ipsilateral multicystic dysplastic kidney in an infant. Reviewed
Fujinaga S, Hirano D, Hara S, Uchida H, Kitano Y, Kobayashi K, Tada M, Someya T, Ohtomo Y, Shimizu T
Pediatric nephrology (Berlin, Germany) Vol. 23 ( 9 ) page: 1551-4 2008.9
The laparoscopic approach of neuroblastoma. Reviewed
Iwanaka T, Kawashima H, Uchida H
Seminars in pediatric surgery Vol. 16 ( 4 ) page: 259-65 2007.11
Usability Needs to be Improved for Patient Safety Reviewed
SOMA T, UCHIDA H, HITSUISHI H, TAKEDA S, NAKAJIMA K
Japan Journal of Medical Informatics Vol. 27 ( 1 ) page: 29 - 32 2007.5
Midterm follow-up study of high-type imperforate anus after laparoscopically assisted anorectoplasty. Reviewed
Kudou S, Iwanaka T, Kawashima H, Uchida H, Nishi A, Yotsumoto K, Kaneko M
Journal of pediatric surgery Vol. 40 ( 12 ) page: 1923-6 2005.12
Complications of laparoscopic surgery in neonates and small infants. Reviewed
Iwanaka T, Uchida H, Kawashima H, Nishi A, Kudou S, Satake R
Journal of pediatric surgery Vol. 39 ( 12 ) page: 1838-41 2004.12
Infantile intestinal leiomyosarcoma is prognostically favorable despite histologic aggressiveness: case report and literature review. Reviewed
Yamamoto H, Tsuchiya T, Ishimaru Y, Kisaki Y, Fujino J, Uchida H, Yoshida M, Mori Y, Ikeda H
Journal of pediatric surgery Vol. 39 ( 8 ) page: 1257-60 2004.8
D-lactic acidosis in short-bowel syndrome managed with antibiotics and probiotics. Reviewed
Uchida H, Yamamoto H, Kisaki Y, Fujino J, Ishimaru Y, Ikeda H
Journal of pediatric surgery Vol. 39 ( 4 ) page: 634-6 2004.4
Umbilicoplasty for large protruding umbilicus accompanying umbilical hernia: a simple and effective technique. Reviewed
Ikeda H, Yamamoto H, Fujino J, Kisaki Y, Uchida H, Ishimaru Y, Hasumi T, Hamajima A
Pediatric surgery international Vol. 20 ( 2 ) page: 105-7 2004.2
Epidermoid cyst: rare testicular tumor in children. Reviewed
Fujino J, Yamamoto H, Kisaki Y, Ishimaru Y, Uchida H, Mori Y, Nozaki M, Ikeda H
Pediatric radiology Vol. 34 ( 2 ) page: 172-4 2004.2
Impact of graft length on surgical damage after intestinal transplantation in rats. Reviewed
Inoue S, Tahara K, Sakuma Y, Hori T, Uchida H, Hakamada Y, Murakami T, Takahashi M, Kawarasaki H, Hashizume K, Kaneko M, Kobayashi E
Transplant immunology Vol. 11 ( 2 ) page: 207-14 2003.4
Impact of graft length on surgical damage after intestinal transplantation in rats Reviewed
S Inoue, K Tahara, Y Sakuma, T Hori, H Uchida, Y Hakamada, T Murakami, M Takahashi, H Kawarasaki, K Hashizume, M Kaneko, E Kobayashi
TRANSPLANT IMMUNOLOGY Vol. 11 ( 2 ) page: 207 - 214 2003.4
Increase of bile acid production by tacrolimus in the rat liver. Reviewed
Mizuta K, Kobayashi E, Uchida H, Hishikawa S, Kawarasaki H
Transplantation proceedings Vol. 35 ( 1 ) page: 437-8 2003.2
Increase of bile acid production by tacrolimus in the rat liver Reviewed
K Mizuta, E Kobayashi, H Uchida, S Hishikawa, H Kawarasaki
TRANSPLANTATION PROCEEDINGS Vol. 35 ( 1 ) page: 437 - 438 2003.2
Short-course methotrexate and long-term acceptance of fully allogeneic rat cardiac grafts: a possible mechanism of tolerance. Reviewed
Sakuma Y, Xiu D, Uchida H, Hakamata Y, Takahashi M, Murakami T, Nagai H, Kobayashi E
Transplant immunology Vol. 10 ( 1 ) page: 49-54 2002.6
Short-course methotrexate and long-term acceptance of fully allogeneic rat cardiac grafts: a possible mechanism of tolerance Reviewed
Sakuma Y, Xiu D, Uchida H, Hakamata Y, Takahashi M, Murakami T, Nagai H, Kobayashi E
TRANSPLANT IMMUNOLOGY Vol. 10 ( 1 ) page: 49 - 54 2002.6
Combined cuff and suture technique for orthotopic whole intestinal transplantation in rats. Reviewed
Nakao A, Tahara K, Inoue S, Mizuta K, Takeichi T, Uchida H, Tanaka N, Kobayashi E
Microsurgery Vol. 22 ( 3 ) page: 85-90 2002
Chronotherapy of sublethal doses of methotrexate on rats allogeneic heart grafts Reviewed International journal
Xiu D.R, Sakuma Y, Nagai H, To H, Sugimoto K, Fujimura A, Uchida H, Kobayashi E
Research Communications in Pharmacology and Toxicology Vol. 7 ( 1-2 ) page: 77 - 85 2002
Comparison of efficacy and toxicity between Sandimmune® and Neoral® in the cyclosporine-resistant rat allo-pancreas transplantation Reviewed International journal
Sakuma Y, Nagai H, Sugimoto K.-I, Fujimura A, Murakami T, Uchida H, Hakamata Y, Takahashi M, Kobayashi E
Research Communications in Pharmacology and Toxicology Vol. 7 ( 1-2 ) page: 86 - 94 2002
Experimental small bowel transplantation using a newborn intestine in rats: IV. Effect of cold preservation on graft neovascularization. Reviewed
Uchida H, Tahara K, Takizawa T, Inose K, Yashiro T, Hashizume K, Ikeda H, Takahashi M, Kobayashi E
Journal of pediatric surgery Vol. 36 ( 12 ) page: 1805-10 2001.12
Experimental small bowel transplantation using a newborn intestine in rats: IV. Effect of cold preservation on graft neovascularization Reviewed
H Uchida, K Tahara, T Takizawa, K Inose, T Yashiro, K Hashizume, H Ikeda, M Takahashi, E Kobayashi
JOURNAL OF PEDIATRIC SURGERY Vol. 36 ( 12 ) page: 1805 - 1810 2001.12
High-dose tacrolimus and lengthy survival of the combined rat pancreas/spleen graft in a high-responder combination. Reviewed
Sakuma Y, Uchida H, Nagai H, Kobayashi E
Transplant immunology Vol. 9 ( 1 ) page: 37-42 2001.10
Y Sakuma, H Uchida, H Nagai, E Kobayashi
TRANSPLANT IMMUNOLOGY Vol. 9 ( 1 ) page: 37 - 42 2001.10
Green fluorescent protein-transgenic rat: a tool for organ transplantation research. Reviewed
Hakamata Y, Tahara K, Uchida H, Sakuma Y, Nakamura M, Kume A, Murakami T, Takahashi M, Takahashi R, Hirabayashi M, Ueda M, Miyoshi I, Kasai N, Kobayashi E
Biochemical and biophysical research communications Vol. 286 ( 4 ) page: 779-85 2001.8
Experimental small bowel transplantation using newborn intestine in rats: III. Long-term cryopreservation of rat newborn intestine. Reviewed
Tahara K, Uchida H, Kawarasaki H, Hasizume K, Kobayashi E
Journal of pediatric surgery Vol. 36 ( 4 ) page: 602-4 2001.4
Experimental small bowel transplantation using newborn intestine in rats: III. Long-term cryopreservation of rat newborn intestine Reviewed
K Tahara, H Uchida, H Kawarasaki, K Hasizume, E Kobayashi
JOURNAL OF PEDIATRIC SURGERY Vol. 36 ( 4 ) page: 602 - 604 2001.4
Rat auxiliary liver transplantation without portal vein reconstruction: comparison with the portal vein-arterialized model. Reviewed
Rong Xiu D, Hishikawa S, Sato M, Nagai H, Uchida H, Kobayashi E
Microsurgery Vol. 21 ( 5 ) page: 189-95 2001
Dosing time-dependent pharmacological effects of anti-metabolites for rat cardiac graft. Reviewed
To H, Xiu DR, Hishikawa S, Uchida H, Sudoh T, Sunaga K, Sugimoto K, Higuchi S, Fujimura A, Kobayashi E
Research communications in molecular pathology and pharmacology Vol. 110 ( 5-6 ) page: 319-32 2001
Orthotopic intestinal transplantation using the cuff method in rats: a histopathological evaluation of the anastomosis. Reviewed
Nakao A, Ogino Y, Tahara K, Uchida H, Kobayashi E
Microsurgery Vol. 21 ( 1 ) page: 12-5 2001
Simplified method of heterotopic rat heart transplantation using the cuff technique: application to sublethal dose protocol of methotrexate on allograft survival. Reviewed
Xiu D, Uchida H, To H, Sugimoto K, Kasahara K, Nagai H, Fujimura A, Kobayashi E
Microsurgery Vol. 21 ( 1 ) page: 16-21 2001
Chronopharmacology of oral prednisolone in rats. Reviewed
Tomizawa N, Uchida H, Xiu DR, To H, Fujimura A, Kobayashi E
Journal of medicine Vol. 32 ( 3-4 ) page: 135-51 2001
Simplified method of heterotopic rat heart transplantation using the cuff technique: Application to sublethal dose protocol of methotrexate on allograft survival Reviewed
Xiu DR, Uchida H, To H, Sugimoto K, Kasahara K, Nagai H, Fujimura A, Kobayashi E
MICROSURGERY Vol. 21 ( 1 ) page: 16 - 21 2001
Orthotopic intestinal transplantation using the cuff method in rats: A histopathological evaluation of the anastomosis Reviewed
A Nakao, Y Ogino, K Tahara, H Uchida, E Kobayashi
MICROSURGERY Vol. 21 ( 1 ) page: 12 - 15 2001
Rat auxiliary liver transplantation without portal vein reconstruction: Comparison with the portal vein-arterialized model Reviewed
Xiu DR, Hishikawa S, Sato M, Nagai H, Uchida H, Kobayashi E
MICROSURGERY Vol. 21 ( 5 ) page: 189 - 195 2001
[Characterization of humoral immunosuppressive factors induced after allogeneic blood transfusion and their application for organ transplantation]. Reviewed
Uchida H, Tanaka H, Tahara K, Kobayashi E
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology Vol. 23 ( 6 ) page: 627-9 2000.12
Hepatic lymphocyte transplantation in hyperbilirubinemic Gunn rats Reviewed
Y Yoshida, E Kobayashi, M Nozawa, H Uchida, A Fujimura, T Yamanaka, M Miyata
EUROPEAN SURGICAL RESEARCH Vol. 32 ( 4 ) page: 223 - 227 2000.7
Effect of erythromycin on ischemia-reperfusion injury of liver in rats. Reviewed
Ohmori M, Miyashita F, Uchida H, Kitoh Y, Tsuruoka S, Harada K, Sugimoto K, Fujimura A, Kobayashi E
Transplantation proceedings Vol. 32 ( 4 ) page: 811-4 2000.6
Effect of erythromycin on ischemia-reperfusion injury of liver in rats Reviewed
Ohmori M, Miyashita F, Uchida H, Kitoh Y, Tsuruoka S, Harada K, Sugimoto K, Fujimura A, Kobayashi E
TRANSPLANTATION PROCEEDINGS Vol. 32 ( 4 ) page: 811 - 814 2000.6
Mechanisms of immunomodulation induced by blood transfusion: identification of humoral factors. Reviewed
Uchida H, Tanaka H, Kitoh Y, Yanagisawa K, To H, Tago K, Mizuta K, Fujimura A, Tominaga S, Hashizume K, Kobayashi E
Transplantation proceedings Vol. 32 ( 2 ) page: 255-6 2000.3
Mechanisms of immunomodulation induced by blood transfusion: Identification of humoral factors Reviewed
H Uchida, H Tanaka, Y Kitoh, K Yanagisawa, H To, K Tago, K Mizuta, A Fujimura, S Tominaga, K Hashizume, E Kobayashi
TRANSPLANTATION PROCEEDINGS Vol. 32 ( 2 ) page: 255 - 256 2000.3
Hepatic lymphocyte transplantation in hyperbilirubinemic gunn rats. Reviewed
Yoshida Y, Kobayashi E, Nozawa M, Uchida H, Fujimura A, Yamanaka T, Miyata M
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes Vol. 32 ( 4 ) page: 223-7 2000
Detection of membrane-bound and soluble-form MHC class I antigen from rat pancreas/spleen grafts during ongoing rejection. Reviewed
Kobayashi E, Lord R, Green M, Walker NI, Kamada N, Uchida H, Fujimura A
Transplantation proceedings Vol. 31 ( 8 ) page: 3409-13 1999.12
E Kobayashi, R Lord, M Green, NI Walker, N Kamada, H Uchida, A Fujimura
TRANSPLANTATION PROCEEDINGS Vol. 31 ( 8 ) page: 3409 - 3413 1999.12
Survival of rats undergoing continuous bile drainage depends on maintenance of circadian rhythm of bile secretion. Reviewed
Mizuta K, Hishikawa S, Yoshida T, Kobayashi E, Uchida H, Fujimura A, Kawarasaki H, Hashizume K
Chronobiology international Vol. 16 ( 6 ) page: 759-65 1999.11
Chronopharmacology of tacrolimus in rats: toxicity and efficacy in a mouse-to-rat intestinal transplant model and its pharmacokinetic profile. Reviewed
Uchida H, Kobayashi E, Ogino Y, Mizuta K, To H, Okabe R, Hashizume K, Fujimura A
Transplantation proceedings Vol. 31 ( 7 ) page: 2751-3 1999.11
Cyclosporine inhibits transport of bile acid in rats: comparison of bile acid composition between liver and bile. Reviewed
Mizuta K, Kobayashi E, Uchida H, Ogino Y, Fujimura A, Kawarasaki H, Hashizume K
Transplantation proceedings Vol. 31 ( 7 ) page: 2755-6 1999.11
Chronotoxicity of mizoribine under repeated administration in the rat. Reviewed
Hishikawa S, To H, Kobayashi E, Uchida H, Fujimura A
Transplantation proceedings Vol. 31 ( 7 ) page: 2765-6 1999.11
Experimental intestinal transplantation using mouse fetal intestine in the rat: combination effect of FK 506 with cyclophosphamide. Reviewed
Uchida H, Kobayashi E, Ogino Y, Mizuta K, Hashizume K, Fujimura A
Transplantation proceedings Vol. 31 ( 7 ) page: 2799-800 1999.11
Experimental intestinal transplantation using mouse fetal intestine in the rat: Combination effect of FK 506 with cyclophosphamide Reviewed
Uchida H, Kobayashi E, Ogino Y, Mizuta K, Hashizume K, Fujimura A
TRANSPLANTATION PROCEEDINGS Vol. 31 ( 7 ) page: 2799 - 2800 1999.11
Chronopharmacology of tacrolimus in rats: Toxicity and efficacy in a mouse-to-rat intestinal transplant model and its pharmacokinetic profile Reviewed
Uchida H, Kobayashi E, Ogino Y, Mizuta K, To H, Okabe R, Hashizume K, Fujimura A
TRANSPLANTATION PROCEEDINGS Vol. 31 ( 7 ) page: 2751 - 2753 1999.11
Chronotoxicity of mizoribine under repeated administration in the rat Reviewed
Hishikawa S, To H, Kobayashi E, Uchida H, Fujimura A
TRANSPLANTATION PROCEEDINGS Vol. 31 ( 7 ) page: 2765 - 2766 1999.11
Cyclosporine inhibits transport of bile acid in rats: Comparison of bile acid composition between liver and bile Reviewed
Mizuta K, Kobayashi E, Uchida H, Ogino Y, Fujimura A, Kawarasaki H, Hashizume K
TRANSPLANTATION PROCEEDINGS Vol. 31 ( 7 ) page: 2755 - 2756 1999.11
Influence of tacrolimus on bile acid and lipid composition in continuously drained bile using a rat model. Reviewed International journal
KOICHI Mizuta, EIJI Kobayashi, HIROO Uchida, AKIO Fujimura, HIDEO Kawarasaki, KOHEI Hashizume
Transplant Int Vol. 12 ( 5 ) page: 316 1999.10
Experimental small bowel transplantation using newborn intestine in rats: II. Revascularization of newborn intestine is independent of vascular endothelial growth factor. Reviewed
Uchida H, Kobayashi E, Yanagisawa K, Mizuta K, Kitoh Y, Fujimura A, Tominaga S, Kawarasaki H, Hashizume K
Journal of pediatric surgery Vol. 34 ( 9 ) page: 1396-400 1999.9
Experimental small bowel transplantation using newborn intestine in rats: II. Revascularization of newborn intestine is independent of vascular endothelial growth factor Reviewed
Uchida H, Kobayashi E, Yanagisawa K, Mizuta K, Kitoh Y, Fujimura A, Tominaga S, Kawarasaki H, Hashizume K
JOURNAL OF PEDIATRIC SURGERY Vol. 34 ( 9 ) page: 1396 - 1400 1999.9
Experimental small bowel transplantation using newborn intestine in rats: I. Lipid absorption restored after transplantation of nonvascularized graft. Reviewed
Uchida H, Yoshida T, Kobayashi E, Mizuta K, Fujimura A, Miyata M, Kawarasaki H, Hashizume K
Journal of pediatric surgery Vol. 34 ( 6 ) page: 1007-11 1999.6
Experimental small bowel transplantation using newborn intestine in rats: I. Lipid absorption restored after transplantation of nonvascularized graft Reviewed
Uchida H, Yoshida T, Kobayashi E, Mizuta K, Fujimura A, Miyata M, Kawarasaki H, Hashizume K
JOURNAL OF PEDIATRIC SURGERY Vol. 34 ( 6 ) page: 1007 - 1011 1999.6
Chronopharmacology for deoxyspergualin: toxicity and efficacy in the rat. Reviewed
Uchida H, Kobayashi E, Matsuda K, Mizuta K, Sugimoto K, Kawarasaki H, Hashizume K, Fujimura A
Transplantation Vol. 67 ( 9 ) page: 1269-74 1999.5
Chronopharmacology for deoxyspergualin - Toxicity and efficacy in the rat Reviewed
Uchida H, Kobayashi E, Matsuda K, Mizuta K, Sugimoto K, Kawarasaki H, Hashizume K, Fujimura A
TRANSPLANTATION Vol. 67 ( 9 ) page: 1269 - 1274 1999.5
Chronopharmacology for deoxyspergualin - Toxicity and efficacy in the rat Reviewed International journal
H Uchida, E Kobayashi, K Matsuda, K Mizuta, K Sugimoto, H Kawarasaki, K Hashizume, A Fujimura
TRANSPLANTATION Vol. 67 ( 9 ) page: 1269 - 1274 1999.5
Influence of tacrolimus on bile acid and lipid composition in continuously drained bile using a rat model. Comparative study with cyclosporine. Reviewed
Mizuta K, Kobayashi E, Uchida H, Fujimura A, Kawarasaki H, Hashizume K
Transplant international : official journal of the European Society for Organ Transplantation Vol. 12 ( 5 ) page: 316-22 1999
Effect of immunosuppressants on bile acid kinetics - Comparative study of cyclosporine with tacrolimus Reviewed International journal
Mizuta K, Kawarasaki H, Hashizume K, Fujimura A, Uchida H, Kobayashi E
Japanese Pharmacology and Therapeutics Vol. 27 ( SUPPL. 7 ) page: 93 - 98 1999
Mechanism of neovascularization in rat newborn organs - Expression of VEGF mRNA and effect of TNP-470 on graft survival Reviewed International journal
Uchida H, Kobayashi E, Yanagisawa K, Mizuta K, Tominaga S.-I, Hashizume K, Fujimura A
Biotherapy Vol. 13 ( 5 ) page: 439 - 441 1999
Survival of rats undergoing continuous bile drainage depends on maintenance of circadian rhythm of bile secretion Reviewed
Mizuta K, Hishikawa S, Yoshida T, Kobayashi E, Uchida H, Fujimura A, Kawarasaki H, Hashizume K
CHRONOBIOLOGY INTERNATIONAL Vol. 16 ( 6 ) page: 759 - 765 1999
Experimental small bowel transplantation using newborn intestine in rats - Some immunological studies and considerations for immunological advantage Reviewed
T Yoshida, H Uchida, E Kobayashi, A Fujimura, M Miyata
JAPANESE JOURNAL OF TRANSPLANTATION Vol. 34 ( 4 ) page: 165 - 173 1999
Do immunosuppressants directly affect neutrophils, resulting in protection of the liver against ischemia-reperfusion injury? Reviewed
Ohmori M, Kobayashi E, Harada K, Kitoh Y, Mizuta K, Uchida H, Ogino Y, Fujimura A
Transplantation Vol. 66 ( 7 ) page: 940-1 1998.10
Dose-dependent reduction of bile secretion in cyclosporine-treated rats. Reviewed
Mizuta K, Kobayashi E, Uchida H, Fujimura A, Kawarasaki H, Hashizume K
Transplantation Vol. 65 ( 5 ) page: 758-9 1998.3
Antenatal diagnosis of biliary atresia (type I cyst) at 19 weeks' gestation: differential diagnosis and etiologic implications. Reviewed
Tsuchida Y, Kawarasaki H, Iwanaka T, Uchida H, Nakanishi H, Uno K
Journal of pediatric surgery Vol. 30 ( 5 ) page: 697-9 1995.5
Introduction to Biliary Atresia International journal
Uchida H, Shirota C, Tainaka T( Role: Joint author)
Singapore, Springer 2021.4
スタンダード小児内視鏡外科手術 : 押さえておきたい手技のポイント
山高 篤行, 内田 広夫, 家入 里志, 田口 智章, 奥山 宏臣( Role: Sole author)
メジカルビュー社 2020 ( ISBN:9784758304672 )
[THE CURRENT SITUATION AND THE DESIRED FUTURE OF PEDIATRIC MINIMALLY INVASIVE SURGERY]. Invited Reviewed
Uchida H
Nihon Geka Gakkai zasshi Vol. 117 ( 4 ) page: 324-8 2016.7
肥厚性幽門狭窄症 (特集 退院から1カ月健診までの新生児対応) -- (見落としてはならない疾患)
村瀬 成彦, 内田 広夫
周産期医学 Vol. 46 ( 1 ) page: 63 - 65 2016.1
Vol. 62 ( 1 ) page: 93 - 99 2014.6
Thoracentesis and chest drainage
The Journal of pediatric practice Vol. 73 ( 5 ) page: 785 - 789 2010.5
Postoperative outcomes of very low birth weight infants with abdominal disorder
Vol. 98 ( 4 ) page: 401 - 405 2009.4
The Journal of pediatric practice Vol. 71 ( 4 ) page: 633 - 637 2008.4
新生児外科--鏡視下検査と鏡視下手術 (特集 周産期画像診断の適応と安全性) -- (新生児の内視鏡検査の適応と安全性)
工藤 寿美, 岩中 督, 内田 広夫
周産期医学 Vol. 34 ( 6 ) page: 905 - 908 2004.6
外科的異常の診かた--小児外科より (特集 乳幼児健診のそこが知りたい) -- (外科的問題)
内田 広夫, 岩中 督
小児科診療 Vol. 67 ( 6 ) page: 919 - 924 2004.6
新生仔小腸を用いた実験的小腸移植:血管新生誘導能の消失と再獲得
田原 和典, 井上 成一朗, 内田 広夫, 金子 隆志, 袴田 陽二, 高橋 将文, 橋都 浩平, 小林 英司
移植 Vol. 37 ( 5 ) page: 212 - 213 2002.10
実験的新生仔小腸移植における血管新生のメカニズム
内田 広夫, 水田 耕一, 小林 英司, 藤村 昭夫, 柳沢 健, 富永 眞一, 橋都 浩平
移植 Vol. 35 ( 2 ) page: 128 - 128 2000.4
RAT ORGAN TRANSPLANTATION USING CUFF ANASTOMOSIS
OGINO Yoshinori, UCHIDA Hiroo, DIAN Xiu Rong, KIYOZAKI Hirokazu, TOYAMA Nobuyuki, KOGURE Hiroaki, FUJIMURA Akio, MIYATA Michio, KOBAYASHI Eiji
Vol. 34 ( 6 ) page: 325 - 347 1999.12
小林 英司, 内田 広夫
日本輸血学会雑誌 Vol. 45 ( 6 ) page: 783 - 783 1999.12
Chronpharmacology for Deoxyspergalin-Clinical trial in Japan-
Vol. 34 ( 4 ) page: 208 - 209 1999.8
新生仔小腸を用いた実験的小腸移植 免疫学的研究とその考察
吉田 卓義, 内田 広夫, 小林 英司, 藤村 昭夫, 宮田 道夫
移植 Vol. 34 ( 4 ) page: 165 - 173 1999.8
On the job training回避を目的とした小児内視鏡手術統合的術前トレーニングシステム・認定プログラムの確立に関する研究
2016.9 - 2019.3
難治性疾患実用化研究事業「Medical Artsの創成に関する研究(外科、がん、看護、リハビリ等の新たな医療技術やソフトウェアの開発)」
内田広夫
Grant type:Competitive
1.小児用VRシミュレータの開発
2.小児用生体質感臓器モデルの開発
3.トレーニングシステムの手技評価方法の選定
4.トレーニングシステムのプロトコール作成
5.トレーニングシステムの有用性の検証
内視鏡外科手術における熟練技術追体験システムを使用したトレーニングシステムの評価
2016.9 - 2019.3
難治性疾患実用化研究事業「Medical Artsの創成に関する研究(外科、がん、看護、リハビリ等の新たな医療技術やソフトウェアの開発)」
安藤 英由樹
Grant type:Competitive
極薄シリコン回路と配線・電極形成テキスタイルによるセンシングウェアの開発
2016.6 - 2019.3
次世代プリンテッドエレクトロニクス材料・プロセス基盤技術開発
Grant type:Competitive
極薄シリコン回路チップをフレキシブル回路基板に集積化したフレキシブル無線モジュールと、配線・電極形成テキスタイルを開発し、これらを接続したセンシングウェアの実証試験を行うことを目的とする。
the establish of off the job training for pediatric minimally invasive surgery and automated analysis system of operative technique
2019.4 - 2022.3
Grant-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(B)
Hiroo Uchida
Authorship:Principal investigator
Development of tracheal stents made from new biodegradable Magnesium alloy
Grant number:19K22654 2019.6 - 2021.3
Grant-in-Aid for Challenging Research (Exploratory)
Authorship:Principal investigator Grant type:Competitive
Grant amount:\6370000 ( Direct Cost: \4900000 、 Indirect Cost:\1470000 )
体内で分解し残存異物とならない新規マグネシウムデバイス開発と各種疾患治療への応用
2016.4 - 2019.3
科学研究費補助金 基盤研究(B)
内田広夫
Authorship:Principal investigator
生分解性マグネシウム合金を用いた各種医療デバイスの開発
超高齢化社会の医療人材不足を克服する次世代医療用ウエアラブルセンサーの新規開発
2016.4 - 2019.3
科学研究費補助金
内田広夫
Authorship:Principal investigator
高感度,高耐久性なウエアラブルセンサーの開発
DDS型超分子デバイスを用いた光線力学療法による難治性小児がん根治への試み
2016.4 - 2018.3
科学研究費補助金
田井中貴久
Authorship:Coinvestigator(s)
ドラッグデリバリーシステム機能が搭載されたインドシアニングリーンを用いた次世代光線力学治療により浸潤性腫瘍や遠隔転移腫瘍を選択的に治療する新たな治療法の開発
新規免疫抑制因子MAY-Iの臓器移植治療への応用とその免疫抑制機序
2002.4 - 2003.3
科学研究費補助金 基盤研究(B)
内田広夫
Authorship:Principal investigator
新規免疫抑制タンパク質MAY-Iはラットinter-alpha-inhibitory H4P heavy chain(H4P)のC末端を含むfragmentであるため、H4Pの組換えタンパク質とH4PでMAY-Iを含まないp-H4Pの組換えタンパク質を作製、精製してその機能を確認した
AI画像解析と鉗子の位置情報を利用した食道閉鎖症手術ナビゲーションシステムの開発
Grant number:22H03703 2022.4 - 2025.3
科学研究費助成事業 基盤研究(B)
内田 広夫
Authorship:Principal investigator
Grant amount:\17290000 ( Direct Cost: \13300000 、 Indirect Cost:\3990000 )
横紋筋肉腫メタボローム解析(尿/組織)による診断マーカーとオンコメタボライト探索
Grant number:22K07911 2022.4 - 2025.3
科学研究費助成事業 基盤研究(C)
住田 亙, 城田 千代栄, 成田 敦, 牧田 智, 田井中 貴久, 内田 広夫, 高橋 義行, 大澤 毅, 田中 裕次郎, 檜 顕成
Authorship:Coinvestigator(s)
小児の肉腫のなかで最も頻度が高い横紋筋肉腫を標的とし、その中心代謝に関与する代謝産物(オンコメタボライト)及びその特異的な代謝系を見出すことを目標に、生体内の情報を鋭敏且つ包括的に捉えやすいメタボロミクス(キャピラリー電気泳動質量分析法を中心に)に着目する。第一段階として、尿検体を研究サンプルとして用い、尿中代謝物解析(CE/MS:キャピラリー電気泳動質量分析法を中心にLC/MS: 液体クロマトグラフィー質量分析法)から、代謝物を網羅的に測定し、横紋筋肉腫の中心代謝に特異的な代謝物(オンコメタボライト)の解明を目指す。
腎芽腫メタボローム解析(尿/組織)による診断マーカーとオンコメタボライト探索
Grant number:22K07276 2022.4 - 2025.3
科学研究費助成事業 基盤研究(C)
岡本 眞宗, 城田 千代栄, 成田 敦, 牧田 智, 田井中 貴久, 内田 広夫, 高橋 義行, 大澤 毅, 住田 亙, 田中 裕次郎, 檜 顕成
Authorship:Coinvestigator(s)
増殖・浸潤・転移などがんの進展における中心代謝と代謝リプログラミングの役割については未だ不明な点が多い。本研究で腎芽腫細胞に特異的な中心代謝に関与する代謝物(オンコメタボライト)を見出す。がん細胞に特異的な代謝系を見出すことにより、正常細胞の代謝系との違いを標的とする新たながんの治療戦略の開発を目指す。腎芽腫患児の尿、腫瘍組織のキャピラリー電気泳動質量分析法を中心とした代謝物解析により、中心代謝に関与するオンコメタボライトを探索し、従来の集学的治療と遺伝子解析だけでは解明できなかった病態解明及び新たな診断治療法の開発に繋げる。
Development of fluorescent probes for diagnosis and treatment of pediatric surgical diseases
Grant number:21K08640 2021.4 - 2024.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Authorship:Coinvestigator(s)
腎芽腫患児の代謝物網羅解析によるバイオマーカーの探索と創薬への挑戦
Grant number:21K07805 2021.4 - 2024.3
科学研究費助成事業 基盤研究(C)
田中 裕次郎, 大澤 毅, 内田 広夫, 檜 顕成, 大島 一夫, 城田 千代栄, 田井中 貴久, 住田 亙, 横田 一樹
Authorship:Coinvestigator(s)
腎芽腫は小児腎腫瘍の90%を占めるが、全体の約10%に予後不良群を認め、診断バイオマーカーが存在しない。最近メタボロミクス技術の発展により生体内の代謝情報を鋭敏且つ包括的に捉えることが可能となり、様々な癌種において新たなバイオマーカーや病態の解明が進んでいる。腎芽腫においても代謝変動の解明が病因解明や新規治療法の開発に寄与すると考えられるが、その代謝変動に着目した診断マーカーや創薬は前例がない。本研究では腎芽腫をターゲットに尿だけでなく、血液、がん組織を加えた腎芽腫50サンプルの代謝物変動を捉えるメタボローム解析を行い、疾患特異的なバイオマーカー探索とその病態解明に挑む。
Development of a self-supporting ultrathin polymer film (nanosheet) for preventing postoperative suture failure and adhesion
Grant number:20K08979 2020.4 - 2023.3
Authorship:Coinvestigator(s) Grant type:Competitive
Single cell transcriptome analysis for the intestinal immunity of neonates
Grant number:18K19503 2018.6 - 2020.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)
SAWA SHINICHIRO
Authorship:Coinvestigator(s) Grant type:Competitive
The first aim of this project was to understand composition and function of immune cells in human neonatal gut. We succeeded in setting up single cell transcriptome analysis about human intestinal cells. The second aim was to clarify etiology of neonatal necrotizing colitis (NEC). In NEC patients, intestinal inflammation and tissue necrosis is evident. Using single cell transcriptome analysis, we identified enhanced expression of chemokine receptors and adhesion molecules on T cells in NEC patients.
リンパ管腫のリンパ動態に基づいた光線力学療法による根治の試み
Grant number:18K08559 2018.4 - 2021.3
高橋 正貴
Authorship:Coinvestigator(s) Grant type:Competitive
本研究では、病変特異的な異常リンパ動態を利用して、病変にのみICGを取り込ませ、蛍光イメージングによる局在診断の有用性を検証する。さらに同部位に近赤外光を照射した際に発生する温熱を利用して、リンパ管腫を選択的に治療する光温熱治療の有効性を実証する。
申請者らはすでに、In vitro実験の検証により、リンパ管腫リンパ管内皮細胞(以下HL-LEC)はICGを取り込み、取り込んだ細胞に近赤外光を照射すると、100%近い細胞の細胞死を誘導することも確認している。また、設定温度が47度以上で確実に細胞死を誘導することを確認している。
今回、申請者は既に確立した背部皮下リンパ管腫モデルマウスを用いてICGによる蛍光イメージングならびに光温熱治療の治療効果を確認した。背部皮下のリンパ管腫モデルマウスにICGを嚢胞内に打ち込み、近赤外光を照射したところ、病理組織学的に移植片のリンパ管内皮細胞を細胞死に導くことができることを確認した。
申請書類と同等の進捗状況である。
申請者らが樹立したリンパ管腫内皮細胞に発光遺伝子(Nano-Lantern)を導入した細胞系を確立している。それを用いて治療効果の検証には、生体イメージングシステム(IVIS®)で、病変の増殖・縮退を経時的に繰り返し観察する。この細胞を用いて作製したモデルマウスにおいては、体外から無侵襲(体毛の剃毛すら不要)かつ短時間(~1 s)に腫瘍局在、サイズ等を検出することができる。一方で超音波イメージングでは50 μmの分解能で、嚢胞や周辺組織を描出できる。定量的な治療効果の検証ができると期待していたが、Nano-Lantern入りHL-LECはIVISで発光せず、定量的な比較が困難であることが判明した。また、モデルマウスの作成に3-4か月を要する。
現時点では当初の予定通りに進んでいるが、上記事項を考慮して研究を進めていく。
動物モデルで治療効果の有効性が明らかなので、対照群と比較して量的に有効性を示す必要性がある。
移植細胞の特殊性と上述した事項から、現時点では定量的評価が困難である。定量的評価を確立させる必要が有るために、HL-LECにfflucやAka-Lucの導入し、In vivo imaging systemを用いて経時的に半定量的評価を行うモデルマウスの作成を予定している。
それらの体表モデルを用いて体表からの照射を行い、コントロール群との治療効果の比較、照射部位の副作用の比較検討を定量的行う。
次のステップとして臨床で遭遇する深部体腔内のリンパ管腫病変を想定し、筋肉内病変モデルや後腹膜腫瘍モデルなどのマウスを作製して、本診断・治療法の有効性を確認する。実臨床に即した照射方法として体表照射のみならず、手術時併用を想定に開創時の照射などを検討予定である。
Challenge to Optimize allocation of Pediatric Surgical Resources by using Remote Medical Platform
Grant number:17H06280 2017.6 - 2020.3
Grant-in-Aid for Challenging Research (Pioneering)
Shirota Chiyoe
Authorship:Coinvestigator(s) Grant type:Competitive
By developing an application and using one-to-many mobile telemedicine to securely link medical sites, we aimed to solve pediatric surgery medical infrastructure and at the same time spread and develop highly specialized telemedicine support. Many doctors can use the application to create a situation where dispersed cases in each region are aggregated in one place (one-to-many remote video conference, image sharing is possible on a smartphone). Can be shared in real time, participate in the consideration of treatment policy, and exchange opinions. We have started to provide highly specialized telemedicine support, which is available 24 hours a day, by securely linking medical fields with desired doctors and hospitals in Japan. The effective use of the system has made it possible to virtually consolidate a specialist with valuable cases.
Highly efficient cancer treatment system combined with a drug-delivery photoabsorbent agent and a tempreature-controled laser system
Grant number:17H02114 2017.4 - 2020.3
Morimoto Yuji
Authorship:Coinvestigator(s) Grant type:Competitive
The applicants have been developing a novel cancer treatment system combined with a drug delivery system light-absorbing agent (ICG lactosome) and photothermal therapy using near-infrared light irradiation system.
In this project, we have developed a laparoscopic camera with an ultra-compact thermosensor array and established a temperature-controlled, endoscopic laser ablation system.
Establishment of an analytical workflow to elucidate the molecular biology of the pathogenesis of gastrointestinal diseases in neonates
Grant number:17H04235 2017.4 - 2020.3
Tanaka Yujiro
Authorship:Coinvestigator(s) Grant type:Competitive
Lymphocytes of 71 resected human bowels were examined using flow cytometry. Type 3 innate lymphoid cells (ILC3), which is known to regulate bowel immunity, was detected in all specimens. However, the percentage of ILC3 was not constant according to the condition of patients, e.g. gestational week and disease. Studying the bowel specimens of emergency laparotomy in human neonates, we also investigated the differences in gene expression between necrotizing enteritis and non-necrotic intestinal perforation. We studied the gene expression on a cell-by-cell basis of about 10,000 cells per each case, so we can assess what cells were specifically showing abnormal responses. To date, there have been no reports of gene expression analysis on a cell-by-cell basis. In necrotizing enteritis, T cells were dominant and pathways concerning inflammation, e.g. MYC targets, mTORC1 signaling, TNFA signaling were activated. In non-necrotic intestinal perforation, innate monocytic cells were the major.
超高齢化社会の医療人材不足を克服する次世代医療用ウエアラブルセンサーの新規開発
2016.4 - 2019.3
日本学術振興会 科学研究費助成事業 萌芽研究
内田広夫, 檜顕成, 吉田学
Authorship:Principal investigator Grant type:Competitive
Grant amount:\3510000 ( Direct Cost: \2700000 、 Indirect Cost:\810000 )
高感度,高耐久性なウエアラブルセンサーの開発
a new wearable multi-lead electrocardiogram measuring system for super-ageing society
Grant number:16K12957 2016.4 - 2019.3
UCHIDA HIROO
Authorship:Principal investigator Grant type:Competitive
Grant amount:\3510000 ( Direct Cost: \2700000 、 Indirect Cost:\810000 )
To develop a wearable multi-lead electrocardiogram (ECG) measuring system, we fabricated the electrode and wiring by using electrostatic flocking technology on a textile. By using this technology, it was possible to fabricate many electrodes and wiring, simultaneously. The fabricated wiring and electrodes had stretchability and wash resistance properties. To use dry electrodes, it is important to reduce the influence of motion artifacts (MAs). we conducted experiments with a human body to determine the relationship between the contact pressure and the MAs. under the pressures of 1000 Pa , 2000Pa and 4000Pa, the ECG signals under rest and deep breathing conditions were able to be measured without MAs. Finally, we fabricated the wearable ECG measuring system and succeeded in measuring 18-lead ECG signals. The measured ECG waveform is in good agreement with the ECG waveform measured by a commercial system.
体内で分解し残存異物とならない新規マグネシウムデバイス開発と各種疾患治療への応用
2016.4 - 2019.3
日本学術振興会 科学研究費助成事業 基盤研究(B)
内田広夫, 檜顕成, 花田幸太郎
Authorship:Principal investigator Grant type:Competitive
Grant amount:\17420000 ( Direct Cost: \13400000 、 Indirect Cost:\4020000 )
生分解性マグネシウム合金を用いた各種医療デバイスの開発
Development of a new biodegradable magnesium alloy for medical equipment
Grant number:16H03197 2016.4 - 2019.3
UCHIDA HIROO
Authorship:Principal investigator Grant type:Competitive
Grant amount:\17420000 ( Direct Cost: \13400000 、 Indirect Cost:\4020000 )
We focus on Mg alloy because it is biodegradable, and has excellent biocompatibility. Mg-based medical devices have already been clinically used as vascular stents and orthopaedic screws. However, Mg staples can easily fracture or degrade at the corners of the B-shape after stapling because of their vulnerability to stress corrosion. Another concern is the production of hydrogen gas caused by the rapid corrosion of Mg in physiological environments.
To address the above challenges, we first redesigned the optimal staple shape to a more rounded form without acute bending points to reduce stress concentrations introduced by stapling and anastomosing. We also developed a novel Mg alloy with sufficiently high ductility to be finely processed to form the shape of a staple and stapled without fracturing. These two patents made us successful in developing Mg alloy staples, and we have confirmed them to be suitable for surgical stapling by rabbit intestinal anastomosis.
Development of Retained Surgical Gauze Detection System before Closing Surgical Incisions.
Grant number:15K15258 2015.4 - 2018.3
Hinoki Akinari
Authorship:Coinvestigator(s) Grant type:Competitive
We found retained surgical gauze while creating several types of surgical gauze detection devices and surgical gauze for detection and detecting eddy current of metallic fiber included in the surgical gauze for detection. Actually, metallic fiber were included in surgical gauze and the change of eddy current was detected from the outside of the body before closing incisions, and the presence or absence of remnant gauze was verified. With respect to silver, the search for degradation kinetics in Both quantitative results of metallic element (silver) and pH change of the extract were very small, and it was judged that the influence of silver itself on the human body was extremely small. Considering biocompatibility, metallic resistance, actual detection distance, and decomposition dynamics in simulated environment of silver in the body, at present, it is necessary to set 4 or 16 circular sections (closed loop windings 3 to 7 times) of silver fibers.
新規免疫抑制因子MAY-Iの臓器移植治療への応用とその免疫抑制機序
2002.4 - 2003.3
日本学術振興会 科学研究費助成事業 基盤研究(B)
内田広夫, 小林英司, 池田均
Authorship:Principal investigator Grant type:Competitive
Grant amount:\7000000 ( Direct Cost: \7000000 )
新規免疫抑制タンパク質MAY-Iはラットinter-alpha-inhibitory H4P heavy chain(H4P)のC末端を含むfragmentであるため、H4Pの組換えタンパク質とH4PでMAY-Iを含まないp-H4Pの組換えタンパク質を作製、精製してその機能を確認した
サーモ内視鏡を有する光温熱治療装置
東海国立大学機構,飛鳥メディカル
新規検査開発サーバ及び新規検査開発方法
東海国立大学機構,日立製作所
尿中腫瘍マーカーによるがん検出方法、キット及び装置
東海国立大学機構,日立製作所
医療用線状材料
法人名大,三井金属鉱業
小児がん検査用尿中代謝物マーカー
東海国立大学機構,日立製作所
小児がんの検査方法
法人名大
生体吸収性ステープル
法人名大,産業技術総合研究所
光治療システム
法人名大,島津製作所
小児外科
2021
pediatric surgery
2020
小児外科学
2014