Updated on 2022/08/05

写真a

 
UCHIDA Hiroo
 
Organization
Institutes of Innovation for Future Society Professor
Graduate School of Medicine Professor
Graduate School
Graduate School of Medicine
Title
Professor
Contact information
メールアドレス
External link

Degree 1

  1. 博士(医学) ( 2001.3   東京大学 ) 

Research Interests 8

  1. pediatric cancer

  2. minimally invasive surgery

  3. medical instrument

  4. pediatric surgery

  5. pediatric surgery

  6. minimally invasive surgery

  7. medical instrument

  8. pediatric cancer

Research Areas 1

  1. Life Science / General surgery and pediatric surgery

Current Research Project and SDGs 3

  1. 胆道閉鎖症の原因解明

  2. 低侵襲手術

  3. pediatric oncology

Research History 18

  1. Nagoya University   Nagoya University Hospital Children's Cancer Center

    2016.4

  2. Nagoya University   Nagoya University Hospital Children's Cancer Center

    2016.4

  3. 名古屋大学大学院医学系研究科 小児外科学 教授

    2013.8

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    Country:Japan

  4. Nagoya University   Graduate School of Medicine

    2013.8

  5. Nagoya University   Graduate School of Medicine Program in Integrated Medicine Musculoskeletal and Cutaneous Medicine   Professor

    2013.8

  6. 埼玉県立小児医療センター 小児外科 科長

    2009.2 - 2013.7

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    Country:Japan

  7. 埼玉県立小児医療センター 小児外科 科長

    2009.2 - 2013.7

  8. 埼玉県立小児医療センター 小児外科 副部長

    2006.4 - 2009.1

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    Country:Japan

  9. 埼玉県立小児医療センター 小児外科 副部長

    2006.4 - 2009.1

  10. 埼玉県立小児医療センター 小児外科 医長

    2003.4 - 2006.3

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    Country:Japan

  11. 埼玉県立小児医療センター 小児外科 医長

    2003.4 - 2006.3

  12. 獨協医科大学越谷病院 小児外科講師

    2001.4 - 2003.3

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    Country:Japan

  13. Dokkyo Medical University   Koshigaya Hospital

    2001.4 - 2003.3

  14. 自治医科大学一般外科・小児外科助手

    1995.7 - 1997.3

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    Country:Japan

  15. 自治医科大学一般外科・小児外科医員

    1994.4 - 1995.6

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    Country:Japan

  16. 東京大学医学部附属病院小児外科医員

    1993.6 - 1994.3

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    Country:Japan

  17. 財団法人竹田綜合病院 外科医員

    1990.12 - 1993.5

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    Country:Japan

  18. 東京大学医学部附属病院第2外科系研修医

    1989.6 - 1990.11

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    Country:Japan

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Education 4

  1. The University of Tokyo   Graduate School, Division of Medical Sciences

    1997.4 - 2001.3

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    Country: Japan

  2. The University of Tokyo   Graduate School, Division of Medical Sciences

    1997.4 - 2001.3

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    Country: Japan

  3. The University of Tokyo   Graduate School, Division of Medical Sciences

    1997.4 - 2001.3

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    Country: Japan

  4. The University of Tokyo   Faculty of Medicine

    1983.4 - 1989.3

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    Country: Japan

Professional Memberships 18

  1. 日本内視鏡外科学会   理事

    2020.12

  2. 日本小児外科学会   理事

    2021.6

  3. 日本外科学会   代議員

    2014.2

  4. 日本内視鏡外科学会

  5. 日本小児外科学会   評議員

    2009.4

  6. International Pediatric Endosurgery Group

  7. The Pacific Association of Pediatric Surgeons

  8. 日本小児血液・がん学会

  9. 日本小児泌尿器科学会

  10. 日本臨床外科学会

  11. International Pediatric Endosurgery Group

  12. 日本臨床外科学会

  13. 日本小児血液・がん学会

  14. 日本小児泌尿器科学会

  15. 日本小児外科学会

  16. 日本外科学会

  17. 日本内視鏡外科学会

  18. The Pacific Association of Pediatric Surgeons

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Papers 220

  1. Histopathologic improvement in biliary cirrhosis after definitive surgery for choledochal cyst. Reviewed

    Ishimaru T, Kitano Y, Uchida H, Kawashima H, Gotoh C, Satoh K, Yoshida M, Kishimoto H, Iwanaka T

    Journal of pediatric surgery   Vol. 45 ( 5 ) page: e11 - 4   2010.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jpedsurg.2010.01.030

    PubMed

  2. Growth spurt-related recurrence after Nuss procedure. Reviewed

    Ishimaru T, Kitano Y, Uchida H, Kawashima H, Gotoh C, Satoh K, Yoshida M, Sugita A, Iwanaka T

    Journal of pediatric surgery   Vol. 44 ( 8 ) page: E13 - 6   2009.8

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    DOI: 10.1016/j.jpedsurg.2009.04.014

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  3. Thoracoscopic posterior tracheopexy during primary esophageal atresia repair ameliorate tracheomalacia in neonates: a single-center retrospective comparative cohort study. Reviewed

    Yasui A, Hinoki A, Amano H, Shirota C, Tainaka T, Sumida W, Yokota K, Makita S, Okamoto M, Takimoto A, Nakagawa Y, Uchida H

    BMC surgery   Vol. 22 ( 1 ) page: 285   2022.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12893-022-01738-1

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  4. Patients with gastric volvulus recurrence have high incidence of wandering spleen requiring laparoscopic gastropexy and splenopexy Reviewed

    Nakagawa Yoichi, Uchida Hiroo, Amano Hizuru, Hinoki Akinari, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Takada Shunya, Kato Daiki

    PEDIATRIC SURGERY INTERNATIONAL     2022.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00383-022-05125-y

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  5. Evaluation of minimally invasive surgical skills training: comparing a neonatal esophageal atresia/tracheoesophageal fistula model with a dry box. Reviewed

    Deie K, Nakagawa Y, Uchida H, Hinoki A, Shirota C, Tainaka T, Sumida W, Yokota K, Makita S, Fujiogi M, Okamoto M, Takimoto A, Yasui A, Takada S, Maeda T

    Surgical endoscopy     2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00464-022-09185-y

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  6. Utility of endoscopic retrograde cholangiopancreatography in management of pediatric pancreaticobiliary disease Reviewed

    Makita Satoshi, Amano Hizuru, Kawashima Hiroki, Hinoki Akinari, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Nakagawa Yoichi, Uchida Hiroo

    BMC PEDIATRICS   Vol. 22 ( 1 ) page: 134   2022.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12887-022-03207-3

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  7. Laparoscopic definitive surgery for congenital biliary dilatation with aggressive hilar bile ductoplasty and complete resection of the intrapancreatic bile duct in pediatric patients is safe and effective, comparable to open surgery Reviewed

    Tainaka Takahisa, Shirota Chiyoe, Hinoki Akinari, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Amano Hizuru, Tanaka Yujiro, Uchida Hiroo

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES     2022.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00464-022-09132-x

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  8. Serum matrix metalloproteinase-7 in biliary atresia: A Japanese multicenter study Reviewed

    Sakaguchi Hirotaka, Konishi Ken-ichiro, Yasuda Ryosuke, Sasaki Hideyuki, Yoshimaru Koichiro, Tainaka Takahisa, Fukahori Suguru, Sanada Yukihiro, Iwama Itaru, Shoji Hiromichi, Kinoshita Masahiro, Matsuura Toshiharu, Fujishiro Jun, Uchida Hiroo, Nio Masaki, Yamashita Yushiro, Mizuochi Tatsuki

    HEPATOLOGY RESEARCH     2022.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/hepr.13753

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  9. Safety and feasibility of primary radical surgery for meconium peritonitis considering patients' general condition and perioperative findings Reviewed

    Nakagawa Yoichi, Uchida Hiroo, Amano Hizuru, Hinoki Akinari, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Takada Shunya, Maeda Takuya

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 1 ) page: 148 - 154   2022.2

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    DOI: 10.18999/nagjms.84.1.148

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  10. Laparoscopic Kasai portoenterostomy can be a standard surgical procedure for treatment of biliary atresia. Reviewed

    Shirota C, Hinoki A, Tainaka T, Sumida W, Kinoshita F, Yokota K, Makita S, Amano H, Nakagawa Y, Uchida H

    World journal of gastrointestinal surgery   Vol. 14 ( 1 ) page: 56 - 63   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4240/wjgs.v14.i1.56

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  11. Laparoscopic definitive surgery for choledochal cyst is performed safely and effectively in infants Reviewed

    Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Amano Hizuru, Okamoto Masamune, Takimoto Aitaro, Kano Yoko, Yasui Akihiro, Nakagawa Yoichi, Hinoki Akinari, Uchida Hiroo

    JOURNAL OF MINIMAL ACCESS SURGERY   Vol. 18 ( 3 ) page: 372 - 377   2022

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.4103/jmas.JMAS_98_21

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  12. Long-term outcomes of the partial splenectomy for hypersplenism after portoenterostomy of patients with biliary atresia Reviewed

    Tainaka Takahisa, Hinoki Akinari, Tanaka Yujiro, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Oshima Kazuo, Amano Hizuru, Takimoto Aitaro, Kano Yoko, Uchida Hiroo

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 4 ) page: 765 - 771   2021.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.18999/nagjms.83.4.765

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  13. Single-incision laparoscopic percutaneous extraperitoneal closure (SILPEC) for inguinal hernia with prolapsed ovary. Reviewed

    Shirota C, Tainaka T, Sumida W, Yokota K, Makita S, Amano H, Okamoto M, Takimoto A, Yasui A, Nakagawa Y, Hinoki A, Uchida H

    Surgical endoscopy     2021.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Surgical Endoscopy  

    Background: Most studies reporting the outcomes of laparoscopic ovarian prolapsed hernia operations with large sample sizes are based on intracorporeal closure, while studies on extraperitoneal closure have limited sample sizes. We proactively used the single-incision laparoscopic percutaneous extraperitoneal closure (SILPEC) technique and obtained favorable outcomes, which we report in this paper. Methods: We retrospectively reviewed patients who had undergone laparoscopic surgery for inguinal hernia at our institution. They were retrospectively classified into two groups based on the pre- or intraoperative diagnosis of hernia with a prolapsed ovary, namely the prolapse group and the non-prolapse group, respectively. The data were statistically analyzed and p < 0.05 was considered statistically significant. Results: A total of 771 subjects underwent SILPEC during the study period, including 400 girls. Among them, 63 girls were diagnosed with an ovarian prolapsed hernia. SILPEC was successfully performed through a single port in all cases, with a single exception, in whom the forceps was inserted directly through the right lower quadrant to pull up the ovary. The duration of surgery in the prolapse group was not higher than that in the non-prolapse group. During the SILPEC surgery, the ovaries were successfully reverted into the abdominal cavity by external compression of the inguinal area alone in 38 of the 63 patients. In the remaining 25 cases, the ovaries were reverted into the abdominal cavity by external compression of the inguinal area and traction of the round ligament with forceps. None of these cases failed to return to the ovaries. Conclusion: Our study results indicate that SILPEC may be performed safely for the treatment of ovarian prolapsed inguinal hernia. Since the ovary and fallopian tube are close to the internal inguinal ring due to the short round ligament, the procedure requires careful suturing with traction of the round ligament.

    DOI: 10.1007/s00464-021-08777-4

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  14. Factors associated with bleeding after endoscopic variceal ligation in children Reviewed

    Yokoyama Shinya, Ishizu Yoji, Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ito Takanori, Hinoki Akinari, Sumida Wataru, Shirota Chiyoe, Tainaka Takahisa, Makita Satoshi, Yokota Kazuki, Uchida Hiroo, Fujishiro Mitsuhiro

    PEDIATRICS INTERNATIONAL   Vol. 63 ( 10 ) page: 1223 - 1229   2021.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Pediatrics International  

    Background: Endoscopic variceal ligation (EVL) is a widely accepted treatment for esophagogastric varices in patients with portal hypertension (PHT). It is used for urgent treatment and prophylactic treatment of esophagogastric varices in pediatric as well as adult patients. However, major life-threatening adverse events such as early rebleeding can occur. Although early rebleeding after EVL among children and adolescents has been reported, the risk factors remain obscure. This study evaluated the risk factors for early rebleeding after EVL in children and adolescents. Methods: The subjects were children and adolescents (<18 years) with PHT who underwent EVL for esophagogastric varices. Early rebleeding was defined as hematemesis, active bleeding, or blood retention in the stomach, confirmed by esophagogastroduodenoscopy from 2 h to 5 days after EVL. Results: A total of 50 EVL sessions on 22 patients were eligible for this study. There were four episodes of early rebleeding. No other major adverse event has occurred. Multivariate analysis showed that EVL implemented at cardiac varices just below the esophagogastric junction (EGJ), within 5 mm from the EGJ, is the independent factor for a higher risk of early rebleeding: odds ratio 18.2 (95% confidence interval: 1.40–237.0), P = 0.02. Conclusions: Children and adolescents who undergo EVL for cardiac varices just below the EGJ have a higher risk of early rebleeding than those who do not.

    DOI: 10.1111/ped.14614

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  15. Late postoperative complications of congenital biliary dilatation in pediatric patients: a single-center experience of managing complications for over 20 years Reviewed

    Amano Hizuru, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Tanaka Yujiro, Hinoki Akinari, Kawashima Hiroki, Uchida Hiroo

    SURGERY TODAY   Vol. 51 ( 9 ) page: 1488 - 1495   2021.9

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    Purpose: To investigate late complications after surgery for congenital biliary dilatation (CBD). Methods: We retrospectively reviewed the patients treated for late postoperative complications of extrahepatic bile duct resection with bilioenteric anastomosis for CBD at our hospital between 1999 and 2019. Results: Twenty-seven complications, including bile duct stenosis with (n = 19) or without (n = 3) hepatolithiasis, remnant intrapancreatic bile duct (n = 2), intestinal obstruction (n = 2), and refractory cholangitis (n = 1) were treated in 26 patients. The median age at radical surgery and the initial treatment of complications was 3 years, 2 months and 14 years, 5 months, respectively. The median period from radical surgery to initial treatment of complications was 7 years, 1 month. Before 2013, bile duct stenosis was initially treated with bile duct plasty (n = 11) or hepatectomy (n = 3), and 71.4% (n = 10) of patients needed further treatment; after 2013, double-balloon endoscopic retrograde cholangiography (DBERC) was used (n = 8), and 25% (n = 2) of patients needed further treatment. Patients with remnant intrapancreatic bile duct, intestinal obstruction, and refractory cholangitis required surgery. Conclusion: Long-term follow-up is necessary after surgery for congenital biliary dilatation. DBERC is thus considered to be useful for bile duct stenosis management.

    DOI: 10.1007/s00595-021-02238-0

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  16. An imaging study on tracheomalacia in infants with esophageal atresia: the degree of tracheal compression by the brachiocephalic artery is a good indicator for therapeutic intervention Reviewed

    Sumida Wataru, Tainaka Takahisa, Shirota Chiyoe, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Yasui Akihiro, Okamoto Masamune, Nakagawa Yoichi, Hinoki Akinari, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL     2021.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Pediatric Surgery International  

    Purpose: Tracheomalacia (TM) is a frequent complication after esophageal atresia (EA) repair. This study aimed to review patients who underwent aortopexy for TM after EA repair and to compare their imaging features. Methods: The patients who underwent thoracoscopic EA repair and contrast-enhanced computed tomography (CECT) at our hospital between 2013 and 2020 were retrospectively reviewed. The ratio of the lateral and anterior–posterior diameter of the trachea (LAR) where the brachiocephalic artery (BCA) crosses the trachea was defined. The LAR of the patients who underwent CECT for asymptomatic pulmonary disease was set as a normal reference. The Z-score of each LAR was calculated and compared between the patients that did or did not undergo aortopexy. Results: A total of 51 patients represented the controls, 5 patients underwent aortopexy, and 12 patients were discharged without surgery. The mean LARs in the patients who underwent aortopexy, did not undergo aortopexy, and controls were 3.54, 1.54, and 1.15, respectively. The mean Z-score of the aortopexy group was 21.2. After successful aortopexy, each patient’s LAR decreased to < 1.5. Conclusion: Aortopexy was preferred if the trachea was compressed by the BCA. The LAR is a useful indicator for predicting the therapeutic effect of aortopexy.

    DOI: 10.1007/s00383-021-04985-0

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  17. Urinary N-1,N-12-diacetylspermine as a biomarker for pediatric cancer: a case-control study Reviewed

    Yokota Kazuki, Hinoki Akinari, Hiramatsu Kyoko, Amano Hizuru, Kawamura Machiko, Kuwatsuka Yachiyo, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Nakagawa Yoichi, Uchida Hiroo, Kawakita Masao

    PEDIATRIC SURGERY INTERNATIONAL     2021.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Pediatric Surgery International  

    Purpose: Minimally invasive examinations are particularly important in pediatric patients. Although the significance of urinary N1,N12-diacetylspermine (DiAcSpm) as a tumor marker (TM) has been reported in many types of adult cancers, its usefulness in pediatric cancers has not been reported. This may be due to urinary DiAcSpm level variations with age. This study aims to measure the normal levels of urinary DiAcSpm in healthy individuals and investigate its usefulness as a TM in childhood cancer. Methods: Urinary samples were collected from pediatric patients with and without cancer. The urinary DiAcSpm levels were measured, and the values were compared. Results: A total of 32 patients with cancer and 405 controls were enrolled in the study. Of the 32 patients, 13 had neuroblastoma, 9 had malignant lymphoma (ML), and 10 had leukemia. In the control group, the urinary DiAcSpm values markedly fluctuated among those with young age, especially infants; meanwhile, the values converged among those aged roughly 10 years and above. The sensitivity of DiAcSpm was significantly different among the three types of cancers: neuroblastoma (30.8%), ML (77.8%), and leukemia (40%). Conclusion: The urinary DiAcSpm value is a useful TM for both screening and follow-up of ML.

    DOI: 10.1007/s00383-021-04987-y

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  18. Comparative study of open and laparoscopic Kasai portoenterostomy in children undergoing living donor liver transplantation for biliary atresia Reviewed

    Takeda Masahiro, Sakamoto Seisuke, Uchida Hajime, Shimizu Seiichi, Yanagi Yusuke, Fukuda Akinari, Uchida Hiroo, Yamataka Atsuyuki, Kasahara Mureo

    PEDIATRIC SURGERY INTERNATIONAL     2021.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Pediatric Surgery International  

    Purpose: The effectiveness of laparoscopic Kasai portoenterostomy (Laparoscopic-KPE) for biliary atresia (BA) has been reported but remains controversial. We reviewed our own cases and cases described in previous studies of liver transplantation (LT) for BA after Laparoscopic-KPE to investigate the efficacy of Laparoscopic-KPE. Methods: Subjects were children of ≤ 2 years old with LT for BA after KPE who underwent Laparoscopic-KPE (n = 10) or Open-KPE (n = 115) between 2009 and 2020. Propensity score matching was performed to reduce the effect of treatment selection bias. The clinical data regarding the preoperative characteristics and surgical results were compared. Results: The rates of hypoplastic portal vein and retrograde portal vein flow were lower in the Laparoscopic-KPE group than in the Open-KPE group (0 vs. 40.0%, p = 0.02 and 0 vs. 35.0%, p = 0.04). There was no marked difference in the operation time or duration of hepatectomy. For portal vein reconstruction, a vein graft was not required in the Laparoscopic-KPE group (0 vs. 35.0%, p = 0.03). No patients in the Laparoscopic-KPE group developed portal vein complications or required re-laparotomy for bowel perforation or re-bleeding, in contrast to the Open-KPE group (0 vs. 15.0% and 0 vs. 10.0%, respectively). Conclusion: Laparoscopic-KPE may reduce postoperative complications that necessitate re-laparotomy in LT.

    DOI: 10.1007/s00383-021-04994-z

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  19. Current thoracoscopic approach for mediastinal neuroblastoma in Japan-results from nationwide multicenter survey Reviewed

    Kawano Takafumi, Souzaki Ryota, Sumida Wataru, Shimojima Naoki, Hishiki Tomoro, Kinoshita Yoshiaki, Uchida Hiroo, Tajiri Tatsuro, Yoneda Akihiro, Oue Takaharu, Kuroda Tatsuo, Hirobe Seiichi, Koshinaga Tsugumichi, Hiyama Eiso, Nio Masaki, Inomata Yukihiro, Taguchi Tomoaki, Ieiri Satoshi

    PEDIATRIC SURGERY INTERNATIONAL     2021.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Pediatric Surgery International  

    Background: Minimally invasive surgery (MIS) is appropriate for the treatment of some neuroblastomas (NBs); however, the indications and technical issues are unclear. This study aimed to clarify the current status of MIS for mediastinal NB in Japan. Methods: Preliminary questionnaires requesting the numbers of neuroblastoma cases in which MIS was performed from 2004 to 2016 were sent to 159 Japanese institutes of pediatric surgery. Secondary questionnaires were sent to institutions with MIS cases to collect detailed data. Results: One hundred thirty-four (84.2%) institutions returned the preliminary questionnaire and 83 institutions (52.2%) reported a total of 1496 operative cases. MIS was performed for 175 (11.6%) cases. Among the 175 cases, completed forms of 140 patients were returned and 40 (male, n = 28; female, n = 12) cases had mediastinal NB. Fourteen patients received thoracoscopic biopsy, none were converted to thoracotomy. Twenty-eight patients received MIS for radical resection, none were converted to thoracotomy. Perioperative complications (Horner’s syndrome) were recognized after radical resection in one (2.5%) case. Conclusions: MIS was performed in a limited number of mediastinal NB cases. A thoracoscopic approach would be feasible for mediastinal NB.

    DOI: 10.1007/s00383-021-04998-9

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  20. Clinical characteristics and outcomes of the right congenital diaphragmatic hernia compared to the left: a 10-year single-center experience Reviewed

    Okamoto Masamune, Amano Hizuru, Uchida Hiroo, Hinoki Akinari, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Yasui Akihiro, Nakagawa Yoichi

    PEDIATRIC SURGERY INTERNATIONAL     2021.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Pediatric Surgery International  

    Purpose: The features of right-sided congenital diaphragmatic hernias (RCDHs) are quite different from those of left-sided CDHs (LCDHs). We have summarized the features of RCDHs experienced in our institution. Methods: This retrospective study analyzed the cases of patients with CDH registered at our institution between 2011 and 2020. Defects on each side were compared based on prenatal diagnosis, medical treatment, type of surgery, and outcomes. Results: A total of 101 patients underwent surgery at our institution during the neonatal period, and 11 had RCDHs. RCDHs and LCDHs were significantly different in terms of extracorporeal membrane oxygenation (36% vs. 6%, p = 0.002), patch repair (81% vs. 28%, p < 0.001), recurrence rate (36% vs. 11%, p = 0.022), and length of hospital stay (117 days vs. 51 days, p = 0.012). The severity of the fetal diagnosis did not reflect postnatal severity. All patients with RCDH survived to discharge, and there was no significant difference in survival rate between the right and left sides. Conclusion: Neonates with RCDH required more intensive treatments; however, the survival rate was comparable between RCDH and LCDH. RCDH was significantly different from LCDH and an optimal treatment strategy for RCDHs should be established.

    DOI: 10.1007/s00383-021-04999-8

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  21. Double common bile duct associated with pancreaticobiliary maljunction Reviewed

    Yamada Kenta, Ishikawa Takuya, Ohno Eizaburo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Yashika Jun, Yoshikawa Masakatsu, Takami Hideki, Inokawa Yoshikuni, Uchida Hiroo, Kawashima Hiroki, Fujishiro Mitsuhiro

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 3 ) page: 655 - 661   2021.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Nagoya Journal of Medical Science  

    A 45-year-old female was admitted to the hospital with a diagnosis of acute pancreatitis. A computed tomography scan showed two extrahepatic bile ducts. Magnetic resonance cholangiopancreatography suggested a stone in one of the bile ducts. Endoscopic retrograde cholangiopancreatography revealed two extrahepatic bile ducts joining at the hilum of the liver accompanied with pancreaticobiliary maljunction. Sphincterotomy was performed and a protein plug was drained from the bile duct. Several treatment options were discussed, and the patient was treated with laparoscopic cholecystectomy without extrahepatic bile duct resection and planned to be followed up considering the risk of carcinogenesis in the bile ducts.

    DOI: 10.18999/nagjms.83.3.655

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  22. Development of a novel diagnostic system for bile duct cancer using urinary metabolites. Reviewed

    Amano Hizuru, Hinoki Akinari, Uchida Hiroo, Yokota Kazuki, Ishigaki Takashi, Sakairi Minoru, Abe Mayumi, Terui Yasushi, Oda Hirohisa, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Okamoto Masamune, Yasui Akihiro, Nakagawa Yoichi

    CANCER RESEARCH   Vol. 81 ( 13 )   2021.7

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  23. A patient with very early onset FH-deficient renal cell carcinoma diagnosed at age seven Reviewed

    Taniguchi Rieko, Muramatsu Hideki, Okuno Yusuke, Yoshida Taro, Wakamatsu Manabu, Hamada Motoharu, Shirota Chiyoe, Sumida Wataru, Hinoki Akinari, Tainaka Takahisa, Gotoh Yoshimitsu, Tsuzuki Toyonori, Tanaka Yukichi, Kojima Seiji, Uchida Hiroo, Takahashi Yoshiyuki

    FAMILIAL CANCER     2021.6

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    Hereditary leiomyomatosis and renal cell cancer (HLRCC) is caused by heterozygous germline variants in the fumarate hydratase (FH) gene and is associated with increased susceptibility to cutaneous leiomyomas, uterine leiomyomas, and renal cell carcinoma (RCC). HLRCC-associated RCC usually occurs in the middle age, with the median age being 40–44 years. This report describes a seven-year-old (84-month-old) male who developed a large right kidney tumor with multiple cystic lesions that contained enhanced solid components. There was no evidence of distant metastasis. The male patient underwent right nephrectomy and has been recovering well without metastasis or recurrence. Pathological examination revealed that tumor cells with relatively prominent nucleoli and surrounded by halos, were located in a limited area. Immunohistochemical staining was negative for FH. Whole-exome sequencing identified his germline variant in the FH gene and its loss of heterozygosity in the tumor. At nine years (114 months) of age, the male patient showed no recurrence of the tumor. This was the youngest-onset case of HLRCC-associated RCC to date. This report may affect the starting age for future RCC-surveillance programs for patients with HLRCC.

    DOI: 10.1007/s10689-021-00268-8

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  24. Laparoscopic approach for abdominal neuroblastoma in Japan: results from nationwide multicenter survey Reviewed

    Kawano Takafumi, Souzaki Ryota, Sumida Wataru, Ishimaru Tetsuya, Fujishiro Jun, Hishiki Tomoro, Kinoshita Yoshiaki, Kawashima Hiroshi, Uchida Hiroo, Tajiri Tatsuro, Yoneda Akihiro, Oue Takaharu, Kuroda Tatsuo, Koshinaga Tsugumichi, Hiyama Eiso, Nio Masaki, Inomata Yukihiro, Taguchi Tomoaki, Ieiri Satoshi

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES     2021.6

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    Background: Some neuroblastoma (NB) cases are suitable for minimally invasive surgery (MIS), but indication and technical issue are unclear. We assessed the current status of MIS for abdominal NB after mass screening period in Japan. Methods: Preliminary questionnaires requesting the numbers of NB cases that underwent MIS from 2004 to 2016 were sent to 159 Japanese institutes of pediatric surgery. The secondary questionnaires were then sent to the institutions that reported MIS cases of NB in order to collect detailed data. Results: One hundred and thirty-four (84.2%) institutions responded to the preliminary questionnaires, and 83 (52.2%) reported managing operative cases. The total number of operative cases was 1496. MIS was performed for 175 (11.6%) cases, of which the completed forms of 140 patients were returned, including 100 abdominal NB cases. The male/female ratio was 51/49. Forty-seven cases underwent a laparoscopic biopsy, and 2 (4.3%) cases were converted to laparotomy due to bleeding. Sixty-five cases underwent MIS for radical resection, and 7 (10.8%) were converted to laparotomy. The reasons for open conversion were bleeding and severe adhesion. Regarding open conversion, there were no significant relationships between conversion and neo-adjuvant chemotherapy, biopsies, stage, size, or MYCN amplification. We found no relationship between resectability and vascular encasement in this study. There was relationship between the resected tumor size and the patients’ height, which was expressed using the following formula: y= 0.0316 x+ 1.4812 (x, patients height, y, tumor size; p = 0.004219, SE: 1.55566). Postoperative complications after radical resection were recognized in 7 (10.8%) cases. Conclusions: MIS was performed in limited cases of abdominal NB. A laparoscopic biopsy with careful attention to bleeding is feasible. The resected tumor size was shown to correlate with the patients’ height. Tumor size within 6 cm of maximum diameter can be resected safely.

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  25. Postoperative intestinal obstruction in patients with biliary atresia impedes biliary excretion and results in subsequent liver transplantation (vol 37, pg 229, 2021) Reviewed

    Takimoto Aitaro, Sumida Wataru, Amano Hizuru, Shirota Chiyoe, Tainaka Takahisa, Yokota Kazuki, Makita Satoshi, Yasui Akihiro, Kanou Yoko, Hinoki Akinari, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 6 ) page: 835 - 835   2021.6

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    A correction to this paper has been published: https://doi.org/10.1007/s00383-021-04873-7.

    DOI: 10.1007/s00383-021-04873-7

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  26. NOVEL BIOMARKER DISCOVERY FOR CHILDHOOD RHABDOMYOSARCOMA USING URINARY METABOLITES Reviewed

    Amano Hizuru, Hinoki Akinari, Uchida Hiroo, Yokota Kazuki, Ishigaki Takashi, Sakairi Minoru, Abe Mayumi, Terui Yasushi, Oda Hirohisa, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Kano Yoko, Okamoto Masamune, Yasui Akihiro, Nakagawa Yoichi

    PEDIATRIC BLOOD & CANCER   Vol. 68   page: S46 - S46   2021.6

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  27. Double-balloon endoscopic retrograde cholangiography can make a reliable diagnosis and good prognosis for postoperative complications of congenital biliary dilatation Reviewed

    Shirota Chiyoe, Kawashima Hiroki, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Amano Hizuru, Takimoto Aitaro, Hinoki Akinari, Uchida Hiroo

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 11052   2021.5

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    Bile duct and anastomotic strictures and intrahepatic stones are common postoperative complications of congenital biliary dilatation (CBD). We performed double-balloon endoscopic retrograde cholangiography (DBERC) for diagnostic and therapeutic purposes after radical surgery. We focused on the effectiveness of DBERC for the treatment of postoperative complications of CBD patients. Bile duct and anastomotic strictures and intrahepatic stones are common postoperative complications of congenital biliary dilatation (CBD). We performed double-balloon endoscopic retrograde cholangiography (DBERC) for diagnostic and therapeutic purposes after radical surgery. We focused on the effectiveness of DBERC for the treatment of postoperative complications of CBD patients. This retrospective study included 28 patients who underwent DBERC (44 procedures) after radical surgery for CBD between January 2011 and December 2019. Strictures were diagnosed as “bile duct strictures” if endoscopy confirmed the presence of bile duct mucosa between the stenotic and anastomotic regions, and as “anastomotic strictures” if the mucosa was absent. The median patient age was 4 (range 0–67) years at the time of primary surgery for CBD and 27.5 (range 8–76) years at the time of DBERC. All anastomotic strictures could be treated with only by 1–2 courses of balloon dilatation of DBERC, while many bile duct strictures (41.2%) needed ≥ 3 treatments, especially those who underwent operative bile duct plasty as the first treatment (83.3%). Although the study was limited by the short follow-up period after DBERC treatment, DBERC is recommended as the first-line treatment for hepatolithiasis associated with biliary and anastomotic strictures in CBD patients, and it can be safely performed multiple times.

    DOI: 10.1038/s41598-021-90550-7

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  28. A Japanese prospective multicenter study of urinary oxysterols in biliary atresia Reviewed

    Konishi Ken-ichiro, Mizuochi Tatsuki, Takei Hajime, Yasuda Ryosuke, Sakaguchi Hirotaka, Ishihara Jun, Takaki Yugo, Kinoshita Masahiro, Hashizume Naoki, Fukahori Suguru, Shoji Hiromichi, Miyano Go, Yoshimaru Koichiro, Matsuura Toshiharu, Sanada Yukihiro, Tainaka Takahisa, Uchida Hiroo, Kubo Yumiko, Tanaka Hiromu, Sasaki Hideyuki, Murai Tsuyoshi, Fujishiro Jun, Yamashita Yushiro, Nio Masaki, Nittono Hiroshi, Kimura Akihiko

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 4986   2021.3

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    Diagnosis of biliary atresia (BA) can involve uncertainties. In the present prospective multicenter study, we considered whether urinary oxysterols represent a useful marker for diagnosis of BA in Japanese children. Subjects under 6 months old at 7 pediatric centers in Japan were prospectively enrolled, including patients with cholestasis and healthy controls (HC) without liver disease. Patients with cholestasis constituted 2 groups representing BA patients and others with cholestasis from other causes (non-BA). We quantitatively analyzed 7 oxysterols including 4β-, 20(S)-, 22(S)-, 22(R)-, 24(S)-, 25-, and 27-hydroxycholesterol by liquid chromatography/electrospray ionization-tandem mass spectrometry. Enrolled subjects included 14 with BA (median age 68 days; range 26–170) and 10 non-BA cholestatic controls (59; 14–162), as well as 10 HC (57; 25–120). Total urinary oxysterols were significantly greater in BA (median, 153.0 μmol/mol creatinine; range 24.1–486.7; P < 0.001) and non-BA (36.2; 5.8–411.3; P < 0.05) than in HC (2.7; 0.8–7.6). In patients with BA, urinary 27-hydroxycholesterol (3.61; 0.42–11.09; P < 0.01) was significantly greater than in non-BA (0.71; 0–5.62). In receiver operating characteristic (ROC) curve analysis for distinguishing BA from non-BA, the area under the ROC curve for urinary 27-hydroxycholesterol was 0.83. In conclusion, this first report of urinary oxysterol analysis in patients with BA indicated that 27-hydroxycholesterol may be a useful marker for distinguishing BA from other causes of neonatal cholestasis.

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  29. Identification of novel neuroblastoma biomarkers in urine samples Reviewed

    Yokota Kazuki, Uchida Hiroo, Sakairi Minoru, Abe Mayumi, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Oshima Kazuo, Makita Satoshi, Amano Hizuru, Hinoki Akinari

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 4055   2021.2

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    Urine is a complex liquid containing numerous small molecular metabolites. The ability to non-invasively test for cancer biomarkers in urine is especially beneficial for screening child patients. This study attempted to identify neuroblastoma biomarkers by comprehensively analysing urinary metabolite samples from children. A total of 87 urine samples were collected from 54 participants (15 children with neuroblastoma and 39 without cancer) and used to perform a comprehensive analysis. Urine metabolites were extracted using liquid chromatography/mass spectrometry and analysed by Metabolon, Inc. Biomarker candidates were extracted using the Wilcoxon rank sum test, random forest method (RF), and orthogonal partial least squares discriminant analysis (OPLS-DA). RF identified three important metabolic pathways in 15 samples from children with neuroblastoma. One metabolite was selected from each of the three identified pathways and combined to create a biomarker candidate (3-MTS, CTN, and COR) that represented each of the three pathways; using this candidate, all 15 cases were accurately distinguishable from the control group. Two cases in which known biomarkers were negative tested positive using this new biomarker. Furthermore, the predictive value did not decrease in cases with a low therapeutic effect. This approach could be effectively applied to identify biomarkers for other cancer types.

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  30. Risk factors and outcomes of bile leak after laparoscopic surgery for congenital biliary dilatation Reviewed International journal

    Tanaka Yujiro, Tainaka Takahisa, Hinoki Akinari, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Oshima Kazuo, Makita Satoshi, Amano Hizuru, Takimoto Aitaro, Kano Yoko, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 2 ) page: 235 - 240   2021.2

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  31. Thoracoscopic surgery for congenital lung cysts: an attempt to limit pulmonary resection in cases of lesions involving multiple lobes Reviewed International journal

    Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Amano Hizuru, Hinoki Akinari, Ono Yasuyuki, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 2 ) page: 213 - 221   2021.2

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  32. Usefulness of web search queries for early detection of diseases in infants Reviewed

    Yamaguchi Shuji, Hinoki Akinari, Tsubouchi Kota, Amandu Hizuru, Tajima Akira, Uchida Hiroo

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 1 ) page: 107 - 111   2021.2

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    Early detection of diseases is critical in infants. This study evaluates the usefulness of web searches in predicting diseases in order to encourage guardians to consult a doctor promptly if their children are ill. We collected six months of search queries from Yahoo! JAPAN Search between October 2016 and March 2017. Using a machine learning model, we investigated the accuracy of the search query’s ability to predict the diagnosis of biliary atresia and hypertrophic pyloric stenosis. Both diseases were modeled with an accuracy of approximately 80&, and symptoms related to the disease were significant features in the model. These findings suggest the possibility of detecting diseases from web search queries performed by guardians. Through future research, we intend to propose a method that uses web search queries for early detection of these diseases by providing appropriate and timely information to support the guardians of patients.

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  33. One-Stage Functional End-To-End Anastomosis Followed by Sutureless Abdominal Wall Closure for Colonic Atresia With Gastroschisis Reviewed

    Chiba Kosuke, Tanaka Yujiro, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Oshima Kazuo, Makita Satoshi, Uchida Hiroo

    Journal of the Japanese Society of Pediatric Surgeons   Vol. 57 ( 1 ) page: 22 - 26   2021

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    <p>The patient was a newborn female with colonic atresia and gastroschisis. A silo was placed immediately after birth and surgery was scheduled the following day. Adhesive detachment was performed by washing the intestinal tract with saline. The oral and anal segments of the colonic atresia were identified, and functional end-to-end anastomosis was performed. Severe edema precluded the immediate return of the intestines to the abdominal cavity and required ongoing treatment with a silo. The intestines gradually returned to the abdominal cavity during the following week. The abdominal wall was closed on postnatal day 9 by a sutureless method. The patient's postoperative course was good, and full feeding was initiated on postnatal day 19. The patient was discharged from the hospital on postnatal day 32 and recovered without complications. In cases of gastroschisis with colonic atresia, a two-stage surgical procedure is commonly employed. However, functional end-to-end anastomosis using a linear stapler is also an effective method because anastomoses can be performed without regard to differences in intestinal caliber.</p>

    DOI: 10.11164/jjsps.57.1_22

  34. Laparoscopic One-Stage Radical Surgery for Congenital Biliary Dilatation With Biliary Perforation Reviewed

    Ishii Hiroki, Makita Satoshi, Yasui Akihiro, Takimoto Aitaro, Yokota Kazuki, Sumida Wataru, Tainaka Takahisa, Shirota Chiyoe, Uchida Hiroo

    Journal of the Japanese Society of Pediatric Surgeons   Vol. 57 ( 5 ) page: 855 - 859   2021

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    <p>A 21-month-old girl with chief complaints of vomiting and fever was admitted to a hospital and diagnosed as having congenital biliary dilatation. Magnetic resonance imaging performed on the sixth day of hospitalization revealed bile duct perforation, and the patient was transferred to our department for further treatment. A perforation approximately 2 cm in diameter was found at the confluence of the common bile duct and cystic duct. We concluded that biliary drainage and repair of the perforation would not improve her pathophysiology. Therefore, laparoscopic one-stage radical surgery was performed. In addition, bile duct plasty was performed to treat the severe intrahepatic bile duct membranous stenosis that were observed in the right and left bile ducts of the hepatic hilum. The patient was discharged without complications on the tenth postoperative day.</p><p>Two-stage surgery is the recommended treatment method for congenital biliary dilatation with biliary perforation. However, in recent years, there have been few reports showing that one-stage open radical surgery is useful. In this case, we successfully performed laparoscopic one-stage radical surgery for congenital biliary dilatation with biliary perforation. If laparoscopic radical surgery for congenital biliary dilatation is established at the institution, and the patient is in good general condition, laparoscopic one-stage radical surgery may be an effective modality for treating this condition.</p>

    DOI: 10.11164/jjsps.57.5_855

  35. A Retrospective Study on the Effect of Surgical Experiences of Laparoscopic Kasai Portenterostomy Reviewed

    Kurano Yui, Shirota Chiyoe, Hinoki Akinari, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Uchida Hiroo

    Journal of the Japanese Society of Pediatric Surgeons   Vol. 57 ( 3 ) page: 596 - 599   2021

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    <p><i>Purpose</i>: The treatment outcomes of patients with laparoscopic surgery for biliary atresia (laparoscopic portoenterostomy) were retrospectively evaluated to determine whether to limit the laparoscopic surgery for biliary atresia to fully experienced surgeons.</p><p><i>Methods</i>: We included 37 patients with laparoscopic portoenterostomy for biliary atresia at our institution from 2014 to 2018. Twelve patients were treated by a surgeon fully experienced in laparoscopic portoenterostomy (Group A) and 23 patients were treated by other surgeons (Group B). Jaundice reduction and jaundice-free survival of patients with the native liver in the two groups were compared.</p><p><i>Results</i>: Differences in age at the time of surgery, body weight, perioperative blood loss, time of drain removal, and time that milk or formula feeding resumed in both groups were not significant. The duration of surgery was significantly shorter in Group A than in Group B. The jaundice-free survival rates of patients with the native liver were 58.3% in Group A and 60.9% in Group B at 6 months after surgery, 66.7% in Group A and 65.2% in Group B at 1 year after surgery, and 58.3% in Group A and 56.5% in Group B at 2 years after surgery. No significant difference was observed.</p><p><i>Conclusions</i>: In this study, no significant difference in the rate of jaundice-free survival of patients with the native liver depending on the amount of surgical experience was observed under the guidance of an operator who was skilled in laparoscopic portoenterostomy.</p>

    DOI: 10.11164/jjsps.57.3_596

  36. Intestinal region reconstruction of ileus cases from 3D CT images based on graphical representation and its visualization Reviewed

    Oda Hirohisa, Hayashi Yuichiro, Kitasaka Takayuki, Tamada Yudai, Takimoto Aitaro, Hinoki Akinari, Uchida Hiroo, Suzuki Kojiro, Itoh Hayato, Oda Masahiro, Mori Kensaku

    MEDICAL IMAGING 2021: COMPUTER-AIDED DIAGNOSIS   Vol. 11597   2021

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    This paper proposes an intestinal region reconstruction method from CT volumes of ileus cases. Binarized intestine segmentation results often contain incorrect contacts or loops. We utilize the 3D U-Net to estimate the distance map, which is high only at the centerlines of the intestines, to obtain regions around the centerlines. Watershed algorithm is utilized with local maximums of the distance maps as seeds for obtaining "intestine segments". Those intestine segments are connected as graphs, for removing incorrect contacts and loops and to extract "intestine paths", which represent how intestines are running. Experimental results using 19 CT volumes showed that our proposed method properly estimated intestine paths. These results were intuitively visualized for understanding the shape of the intestines and finding obstructions.

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  37. A novel Lugol's iodine staining technique to visualize the upper margin of the surgical anal canal intraoperatively for Hirschsprung disease: a case series Reviewed International journal

    Yokota Kazuki, Amano Hizuru, Kudo Toyoki, Yamamura Takeshi, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Nakamura Masanao, Fujishiro Mitsuhiro, Hinoki Akinari, Uchida Hiroo

    BMC SURGERY   Vol. 20 ( 1 )   2020.12

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    DOI: 10.1186/s12893-020-00986-3

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  38. URINARY OXYSTEROLS IN BILIARY ATRESIA: A PROSPECTIVE MULTICENTER STUDY IN JAPAN Reviewed

    Konishi Ken-ichiro, Mizuochi Tatsuki, Takei Hajime, Yesuda Ryosuke, Sakaguchi Hirotaka, Ishihara Jun, Takaki Yugo, Kinoshita Masahiro, Hashizume Naoki, Fukahori Suguru, Shoji Hiromichi, Miyano Go, Yoshimaru Koichiro, Matsuura Toshiharu, Sanada Yukihiro, Tainaka Takahisa, Uchida Hiroo, Kubo Yumiko, Tanaka Hiromu, Sasaki Hideyuki, Murai Tsuyoshi, Fujishiro Jun, Yamashita Yushiro, Nio Masaki, Nittono Hiroshi, Kimura Akihiko

    HEPATOLOGY   Vol. 72   page: 224A - 225A   2020.11

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  39. Safe diagnostic management of malignant mediastinal tumors in the presence of respiratory distress: a 10-year experience Reviewed International journal

    Tanaka Tomoko, Amano Hizuru, Tanaka Yujiro, Takahashi Yoshiyuki, Tajiri Tatsuro, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Tani Yukiko, Hinoki Akinari, Uchida Hiroo

    BMC PEDIATRICS   Vol. 20 ( 1 )   2020.6

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    DOI: 10.1186/s12887-020-02183-w

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  40. Clinical characteristics and surgical outcomes of retroperitoneal tumors: a comprehensive data collection from multiple departments Reviewed International journal

    Sassa Naoto, Yokoyama Yukihiro, Nishida Yoshihiro, Yamada Suguru, Uchida Hiroo, Kajiyama Hiroaki, Nagino Masato, Kodera Yasuhiro, Gotoh Momokazu

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 5 ) page: 929 - 936   2020.5

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    DOI: 10.1007/s10147-020-01620-1

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  41. Intestinal flow after anastomotic operations in neonates Reviewed International journal

    Ito Yasumasa, Asato Koichiro, Cho Inhyeok, Sakai Yasuhiko, Iwano Koji, Tainaka Takahisa, Uchida Hiroo

    COMPUTERS IN BIOLOGY AND MEDICINE   Vol. 118   2020.3

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    DOI: 10.1016/j.compbiomed.2019.103471

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  42. Novel zinc alloys for biodegradable surgical staples Reviewed International journal

    Amano Hizuru, Miyake Koichi, Hinoki Akinari, Yokota Kazuki, Kinoshita Fumie, Nakazawa Atsuko, Tanaka Yujiro, Seto Yasuhiro, Uchida Hiroo

    WORLD JOURNAL OF CLINICAL CASES   Vol. 8 ( 3 ) page: 504 - 516   2020.2

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  43. 術中膵管損傷に対して内視鏡的に膵管ステントを挿入した1例 Reviewed

    城田 千代栄, 檜 顕成, 内田 広夫, 田井中 貴久, 住田 亙, 横田 一樹, 牧田 智, 天野 日出, 滝本 愛太朗, 安井 昭洋, 石井 宏樹

    日本膵・胆管合流異常研究会プロシーディングス   Vol. 43 ( 0 ) page: 84 - 85   2020

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    DOI: 10.34410/jspbm.43.0_84

  44. 小児腹腔鏡手術における肝内胆管形成術 Reviewed

    田井中 貴久, 内田 広夫, 城田 千代栄, 住田 亙, 横田 一樹, 牧田 智, 滝本 愛太朗, 安井 昭洋, 石井 宏樹, 檜 顕成

    日本膵・胆管合流異常研究会プロシーディングス   Vol. 43 ( 0 ) page: 36 - 36   2020

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    DOI: 10.34410/jspbm.43.0_36

  45. Visualizing intestines for diagnostic assistance of ileus based on intestinal region segmentation from 3D CT images Reviewed

    Oda Hirohisa, Nishio Kohei, Kitasaka Takayuki, Amano Hizuru, Takimoto Aitaro, Uchida Hiroo, Suzuki Kojiro, Itoh Hayato, Oda Masahiro, Mori Kensaku

    MEDICAL IMAGING 2020: COMPUTER-AIDED DIAGNOSIS   Vol. 11314   2020

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    This paper presents a visualization method of intestine (the small and large intestine) regions and their stenosed parts caused by ileus from CT volumes. Since it is difficult for non-expert clinicians to find stenosed parts, the intestine and its stenosed parts should be visualized intuitively. Furthermore, the intestine regions of ileus cases are quite hard to be segmented. The proposed method segments intestine regions by 3D FCN (3D U-Net). Intestine regions are quite difficult to be segmented in ileus cases since the inside the intestine is filled with liquids. These liquids have similar intensities with intestinal wall on 3D CT volumes. We segment the intestine regions by using 3D U-Net trained by a weak annotation approach. Weak-annotation makes possible to train the 3D U-Net with small manually-traced label images of the intestine. This avoids us to prepare many annotation labels of the intestine that has long and winding shape. Each intestine segment is volume-rendered and colored based on the distance from its endpoint in volume rendering. Stenosed parts (disjoint points of an intestine segment) can be easily identified on such visualization. In the experiments, we showed that stenosed parts were intuitively visualized as endpoints of segmented regions, which are colored by red or blue.

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  46. Identification and Validation of Novel Non-invasive Biomarkers in Patient Urine Samples for Diagnosis of New and Recurrent Neuroblastoma Reviewed International journal

    Yokota Kazuki, Uchida Hiroo, Hinoki Akinari, Sakairi Minoru, Abe Mayumi, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Oshima Kazuo, Makita Satoshi, Takimoto Aitaro, Kano Yoko, Inada Kosuke

    PEDIATRIC BLOOD & CANCER   Vol. 66   page: S106 - S106   2019.12

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  47. Biodegradable Surgical Staple Composed of Magnesium Alloy.

    Amano H, Hanada K, Hinoki A, Tainaka T, Shirota C, Sumida W, Yokota K, Murase N, Oshima K, Chiba K, Tanaka Y, Uchida H

    Scientific reports   Vol. 9 ( 1 ) page: 14671   2019.10

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    DOI: 10.1038/s41598-019-51123-x

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  48. Therapeutic strategy for thoracoscopic repair of esophageal atresia and its outcome

    Shirota Chiyoe, Tanaka Yujiro, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Oshima Kazuo, Tanaka Tomoko, Tani Yukiko, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 35 ( 10 ) page: 1071-1076   2019.10

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    DOI: 10.1007/s00383-019-04541-x

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  49. Efficacy of and prognosis after steroid pulse therapy in patients with poor reduction of jaundice after laparoscopic Kasai portoenterostomy

    Tanaka Yujiro, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Oshima Kazuo, Makita Satoshi, Tanaka Tomoko, Tani Yukiko, Chiba Kosuke, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 35 ( 10 ) page: 1059-1063   2019.10

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    DOI: 10.1007/s00383-019-04537-7

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  50. NON-INVASIVE SCREENING FOR DETECTING ESOPHAGOGASTRIC VARICES IN CHILDREN WITH BILIARY ATRESIA Reviewed International journal

    Yokoyama Shinya, Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ito Takanori, Shirota Chiyoe, Uchida Hiroo, Fujishiro Mitsuhiro

    HEPATOLOGY   Vol. 70   page: 200A - 200A   2019.10

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  51. Laparoscopic Kasai portoenterostomy is advantageous over open Kasai portoenterostomy in subsequent liver transplantation.

    Shirota C, Murase N, Tanaka Y, Ogura Y, Nakatochi M, Kamei H, Kurata N, Hinoki A, Tainaka T, Sumida W, Yokota K, Makita S, Oshima K, Uchida H

    Surgical endoscopy     2019.9

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    DOI: 10.1007/s00464-019-07108-y

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  52. Spleen stiffness by 2-D shear wave elastography is the most accurate predictor of high-risk esophagogastric varices in children with biliary atresia.

    Yokoyama S, Ishigami M, Honda T, Kuzuya T, Ishizu Y, Ito T, Hirooka Y, Tanaka Y, Tainaka T, Shirota C, Chiba K, Uchida H, Fujishiro M

    Hepatology research : the official journal of the Japan Society of Hepatology     2019.5

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    DOI: 10.1111/hepr.13381

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  53. Relationship between Contact Pressure and Motion Artifacts in ECG Measurement with Electrostatic Flocked Electrodes Fabricated on Textile

    Takeshita Toshihiro, Yoshida Manabu, Takei Yusuke, Ouchi Atsushi, Hinoki Akinari, Uchida Hiroo, Kobayashi Takeshi

    SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page: 5897   2019.4

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    DOI: 10.1038/s41598-019-42027-x

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  54. Multicenter, retrospective, comparative study of laparoscopic and open Kasai portoenterostomy in children with biliary atresia from Japanese high-volume centers

    Murase Naruhiko, Hinoki Akinari, Shirota Chiyoe, Tomita Hirofumi, Shimojima Naoki, Sasaki Hideyuki, Nio Masaki, Tahara Kazunori, Kanamori Yutaka, Shinkai Masato, Yamamoto Hirotoshi, Sugawara Yasuhiko, Hibi Taizo, Ishimaru Tetsuya, Kawashima Hiroshi, Koga Hiroyuki, Yamataka Atsuyuki, Uchida Hiroo

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 26 ( 1 ) page: 43-50   2019.1

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    DOI: 10.1002/jhbp.594

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  55. 静電植毛技術を用いた心電図測定用立体ドライ電極の作製と応用 Reviewed

    竹下 俊弘, 吉田 学, 竹井 裕介, 大内 篤, 檜 顕成, 内田 広夫, 小林 健

    エレクトロニクス実装学術講演大会講演論文集   Vol. 33 ( 0 ) page: 13A2-01   2019

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    <p>心電図モニタリング用のドライ電極の開発を行った。ドライ電極を用いた心電図モニタリングにおいての課題は皮膚-電極間の安定した接触である。我々は立体構造の樹脂に銀メッキ加工を施した繊維を静電植毛することにより、体の形状に沿った形状であり、皮膚-電極間の安定した接触を実現した、ドライ電極の作製を行った。また作製したドライ電極を用いて心電図モニタリングウェアを作製し、医療的意義のある心電図測定に成功した。</p>

    DOI: 10.11486/ejisso.33.0_13a2-01

    CiNii Research

  56. 内視鏡外科手術における熟練医の追体験トレーニングシステムとその評価 Reviewed

    安藤 英由樹, 坂井 義治, 小濱 和貴, 内田 広夫, 出家 亨一, 松田 公志, 吉田 健志, 早石 直広

    生体医工学   Vol. 57 ( 0 ) page: S198_1 - S198_1   2019

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    <p>腹腔鏡手術は低侵襲性であることから普及が進んでいる。しかしながら、カメラを通じた状況把握、ポート留置部を支点とするため移動方向が手の動きと逆になる腹腔鏡用鉗子の利用など、手術の難易度が高く、習得に時間がかかることことから熟練者不足が問題となっている。また熟練医の不足は修練者のための教育に当てる時間も不足するという悪循環を生んでいる。従って、熟練者を短期間で養成し増やすための術式教育そのものが重要な課題である。本研究では、内視鏡外科手術は術野像がモニタによって同じ視野が「共有される」という特性を利用して、段階的な学習ステップに応じた、熟練者の適切かつスムースな動きを修練者が追体験することで、非言語的なスキルの伝達を行い、効果的なトレーニングを行うシステムである「追いトレ」を用いた場合の効果について、妥当性、効果の範囲、適応可能な範囲を明らかし、製品化・実用化・普及を実現するエビデンスを獲得するために、様々な内視鏡外科分野で十分な検証実験を踏まえたデータ取得とデータ解析を行なうことを目的とした。</p>

    DOI: 10.11239/jsmbe.Annual57.S198_1

  57. Nuss procedure for patients with pectus excavatum with a history of intrathoracic surgery.

    Takanari K, Toriyama K, Kambe M, Nakamura Y, Uchibori T, Ebisawa K, Shirota C, Tainaka T, Uchida H, Kamei Y

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS     2018.12

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    DOI: 10.1016/j.bjps.2018.12.027

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  58. Air test as a simple method of screening for Hirschsprung's disease

    Sumida W., Uchida H., Ono Y., Tanaka Y., Tainaka T., Shirota C., Yokota K., Oshima K., Chiba K.

    CLINICAL RADIOLOGY   Vol. 73 ( 12 ) page: 1041-1045   2018.12

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    DOI: 10.1016/j.crad.2018.08.008

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  59. A new laparoscopic triangle fixation technique for gastrostomy: a safe and effective procedure for reduction of the wound infection rate Reviewed

    Fujiogi Michimasa, Tanaka Yujiro, Amano Hizuru, Deie Kyoichi, Suzuki Keisuke, Kawashima Hiroshi, Murase Naruhiko, Uchida Hiroo

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 4 ) page: 497 - 503   2018.11

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    DOI: 10.18999/nagjms.80.4.497

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  60. Indications for total esophagogastric dissociation in children with gastroesophageal reflux disease

    Tanaka Yujiro, Tainaka Takahisa, Uchida Hiroo

    SURGERY TODAY   Vol. 48 ( 11 ) page: 971-977   2018.11

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    DOI: 10.1007/s00595-018-1636-9

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  61. Laparoscopically Assisted Anorectoplasty for Intermediate-Type Imperforate Anus: Comparison of Surgical Outcomes with the Sacroperineal Approach

    Ishimaru Tetsuya, Kawashima Hiroshi, Tainaka Takahisa, Suzuki Keisuke, Takami Shohei, Kakihara Tomo, Katoh Reiko, Aoyama Tomohiro, Uchida Hiroo, Iwanaka Tadashi

    JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES     2018.10

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    DOI: 10.1089/lap.2018.0330

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  62. Single-stage laparoscopic transanal pull-through modified Swenson procedure without leaving a muscular cuff for short- and long-type Hirschsprung disease: a comparative study

    Yokota Kazuki, Uchida Hiroo, Tainaka Takahisa, Tanaka Yujiro, Shirota Chiyoe, Hinoki Akinari, Kato Takazumi, Sumida Wataru, Oshima Kazuo, Chiba Kosuke, Ishimaru Tetsuya, Kawashima Hiroshi

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 34 ( 10 ) page: 1105-1110   2018.10

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    DOI: 10.1007/s00383-018-4318-1

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  63. The impact of body weight on stapled anastomosis in pediatric patients

    Amano Hizuru, Tanaka Yujiro, Tainaka Takahisa, Hinoki Akinari, Kawashima Hiroshi, Kakihara Tomo, Morita Kaori, Uchida Hiroo

    JOURNAL OF PEDIATRIC SURGERY   Vol. 53 ( 10 ) page: 2036-2040   2018.10

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    DOI: 10.1016/j.jpedsurg.2018.04.030

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  64. Oral administration of eicosapentaenoic acid suppresses liver fibrosis in postoperative patients with biliary atresia

    Sumida Wataru, Uchida Hiroo, Tainaka Takahisa, Shirota Chiyoe, Hinoki Akinari, Kato Takazumi, Yokota Kazuki, Oshima Kazuo, Shirotuki Ryo, Chiba Kosuke, Tanaka Yujiro

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 34 ( 10 ) page: 1059-1063   2018.10

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    DOI: 10.1007/s00383-018-4313-6

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  65. Long-term outcomes and complications after laparoscopic-assisted anorectoplasty vs. posterior sagittal anorectoplasty for high- and intermediate-type anorectal malformation. Reviewed International journal

    Takahisa Tainaka, Hiroo Uchida, Yujiro Tanaka, Akinari Hinoki, Chiyoe Shirota, Wataru Sumida, Kazuki Yokota, Satoshi Makita, Kazuo Oshima, Kosuke Chiba, Tetsuya Ishimaru, Hiroshi Kawashima

    Pediatric surgery international   Vol. 34 ( 10 ) page: 1111 - 1115   2018.10

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    PURPOSE: Laparoscopic-assisted anorectoplasty (LAARP) is a minimally invasive procedure in which the levator ani muscle is left to potentially improve postoperative fecal continence. This study aimed to retrospectively evaluate postoperative complications and long-term outcomes of fecal continence after LAARP and compare them to those after posterior sagittal anorectoplasty (PSARP). METHODS: Forty-five male patients with high and intermediate anorectal malformation (aged ≥ 4 years) who underwent LAARP or PSARP (LAARP 29, PSARP 16) from 1999 to 2013 were included. Postoperative complications and postoperative fecal continence were retrospectively evaluated and compared. Postoperative complications were also compared before and after introducing a urethroscope during fistula resection. RESULTS: Complications after LAARP and PSARP were seen in 12 vs. 2 cases (p = 0.09) of mucosal prolapse and in 9 vs. 1 case (p = 0.07) of posterior urethral diverticulum (PUD), respectively. The incidence of PUD decreased after introduction of a urethroscopy from 40% in 8/20 cases to 11% in 1/9 cases. No significant difference was found in terms of fecal continence in both groups. CONCLUSION: Through our study, greater improvement of postoperative fecal continence after LAARP has not been shown. LAARP was at higher risk for mucosal prolapse and PUD. However, precise dissection of the urethral fistula could be performed after the introduction of urethroscopy.

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  66. Investigation of the feasibility and safety of single-stage anorectoplasty in neonates with anovestibular fistula. Reviewed International journal

    Chiyoe Shirota, Keisuke Suzuki, Hiroo Uchida, Hiroshi Kawashima, Akinari Hinoki, Takahisa Tainaka, Wataru Sumida, Naruhiko Murase, Kazuo Oshima, Kosuke Chiba, Satoshi Makita, Yujiro Tanaka

    Pediatric surgery international   Vol. 34 ( 10 ) page: 1117 - 1120   2018.10

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    PURPOSE: Anovestibular fistula (AVF) is the most common type of anorectal malformation in females. Delayed anorectoplasty with fistula dilatation is commonly performed during infancy; however, we have been actively performing anorectoplasty in neonates. We report the surgical complications and postoperative defecation function associated with single-stage anorectoplasty performed in neonates. METHODS: Patients who underwent surgery for AVF between 2007 and 2017 at two institutions were retrospectively studied. The operation time, amount of bleeding, time to start oral intake, perioperative complications, and Kelly's score were compared among patients who underwent surgery as neonates and those who underwent surgery as infants. RESULTS: Eighteen neonates and 17 infants underwent anterior sagittal anorectoplasty. The median operation time and time to start oral intake were significantly shorter in the neonatal group (72 min; 3 days, respectively) than in the infant group (110 min, p = 0.0002; 5 days, p = 0.0024, respectively). Postoperative wound disruption was significantly more frequent in the infant group. Of the ten patients each in the neonatal and infant groups, there was no significant difference in Kelly's score at age ≥ 4 years. CONCLUSION: Single-stage anorectoplasty in neonates with AVF can be feasibly performed and does not impair postoperative defecation function. LEVELS OF EVIDENCE: III.

    DOI: 10.1007/s00383-018-4324-3

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  67. Introduction of resection of intrahepatic bile duct stenosis-causing membrane or septum into laparoscopic choledochal cyst excision

    Tanaka Yujiro, Tainaka Takahisa, Sumida Wataru, Hinoki Akinari, Shirota Chiyoe, Murase Naruhiko, Oshima Kazuo, Shirotsuki Ryo, Chiba Kosuke, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 34 ( 10 ) page: 1087-1092   2018.10

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    DOI: 10.1007/s00383-018-4320-7

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  68. BESNet: Boundary-enhanced Segmentation of Cells in Histopathological Images

    Hirohisa Oda, Holger Roth, Kosuke Chiba, Jure Sokolic, Takayuki Kitasaka, Masahiro Oda, Akinari Hinoki, Hiroo Uchida, Julia A Schnabel, Kensaku Mori

    MICCAI 2018, LNCS 11071     page: 228-236   2018.9

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  69. Automated ganglion cell detection using fully convolutional networks and evaluation under different training losses

    Hirohisa Oda, Kosuke Chiba, Holger R. Roth, Takayuki Kitasaka, Masahiro Oda, Akinari Hinoki, Hiroo Uchida, Kensaku Mori

    International Journal of Computer Assisted Radiology and Surgery   Vol. 13 ( 1 ) page: s104-106   2018.6

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  70. Novel thoracoscopic navigation surgery for neonatal chylothorax using indocyanine-green fluorescent lymphography. Reviewed International journal

    Ryo Shirotsuki, Hiroo Uchida, Yujiro Tanaka, Chiyoe Shirota, Kazuki Yokota, Naruhiko Murase, Akinari Hinoki, Kazuo Oshima, Kosuke Chiba, Wataru Sumida, Masahiro Hayakawa, Takahisa Tainaka

    Journal of pediatric surgery   Vol. 53 ( 6 ) page: 1246 - 1249   2018.6

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    BACKGROUND: Postoperative chylothorax after surgery for esophageal atresia/tracheoesophageal fistula (TEF) is a rare but serious complication, especially in neonates. This study aimed to identify the thoracic duct and ligate chylous leakage sites, using thoracoscopic navigation of an indocyanine-green (ICG)-based near-infrared (NIR) fluorescence imaging system. METHODS: From November 2014 to April 2017, thoracoscopic intraoperative ICG-NIR imaging was performed in 10 newborns (11 surgeries) with first TEF operation or with persistent postoperative chylothorax after TEF operation. NIR imaging was performed 1h after an inter-toe injection of ICG. Thoracoscopic ligations against the NIR-detected leakage sites were performed with sutures. RESULTS: The thoracic duct or lymphatic leakage was directly visualized in each patient. In 8 surgeries with first thoracoscopic TEF operation, one case had suspected minor chylous leakage without postoperative chylothorax. Another case with no chylous leakage at the first operation resulted in chylothorax at postoperative day 11. In three neonates with postoperative chylothorax, leakage points were detected near the ablation site of the azygos vein during the first operation. These points were properly ligated, and postoperative chylous leakage ceased with no adverse events. CONCLUSIONS: Thoracoscopic ICG-NIR imaging encourages the repair of refractory chylothorax and seems reliable. LEVEL OF EVIDENCE: IV.

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  71. 特集 小児外科における消化器内視鏡外科手術 胆道閉鎖症に対する腹腔鏡下肝門部空腸吻合術 Reviewed

    内田 広夫, 田中 裕次郎, 田井中 貴久, 城田 千代栄, 住田 亙, 村瀬 成彦

    手術   Vol. 72 ( 6 ) page: 861 - 870   2018.5

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    DOI: 10.18888/op.0000000707

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  72. Clinical, Pathologic, and Genetic Features of Neonatal Dubin-Johnson Syndrome: A Multicenter Study in Japan

    Togawa Takao, Mizuochi Tatsuki, Sugiura Tokio, Kusano Hironori, Tanikawa Ken, Sasaki Takato, Ichinose Fumio, Kagimoto Seiichi, Tainaka Takahisa, Uchida Hiroo, Saitoh Shinji

    JOURNAL OF PEDIATRICS   Vol. 196   page: 161-+   2018.5

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    DOI: 10.1016/j.jpeds.2017.12.058

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  73. Evaluation of Surgical Devices Using an Artificial Pediatric Thoracic Model: A Comparison Between Robot-Assisted Thoracoscopic Suturing Versus Conventional Video-Assisted Thoracoscopic Suturing

    Takazawa Shinya, Ishimaru Tetsuya, Harada Kanako, Deie Kyoichi, Hinoki Akinari, Uchida Hiroo, Sugita Naohiko, Mitsuishi Mamoru, Iwanaka Tadashi, Fujishiro Jun

    JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES   Vol. 28 ( 5 ) page: 622-627   2018.5

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    DOI: 10.1089/lap.2017.0307

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  74. Usefulness of fetal magnetic resonance imaging for postnatal management of congenital lung cysts: prediction of probability for emergency surgery

    Shirota Chiyoe, Tainaka Takahisa, Nakane Toshiki, Tanaka Yujiro, Hinoki Akinari, Sumida Wataru, Murase Naruhiko, Oshima Kazuo, Chiba Kosuke, Shirotsuki Ryo, Uchida Hiroo

    BMC PEDIATRICS   Vol. 18 ( 1 ) page: 105   2018.3

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    DOI: 10.1186/s12887-018-1085-z

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  75. Fabrication of Multi-lead ECG measurement wear using electrostatic flocking technology Reviewed

    Proceedings of JIEP Annual Meeting   Vol. 32 ( 0 ) page: 179 - 180   2018

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    DOI: 10.11486/ejisso.32.0_179

  76. Idiopathic Omental Torsion Relieved With Conservative Management Reviewed

    Yokota Kazuki, Chiba Kosuke, Uchida Hiroo, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Hinoki Akinari, Sumida Wataru, Kato Takazumi, Oshima Kazuo

    Journal of the Japanese Society of Pediatric Surgeons   Vol. 54 ( 2 ) page: 302 - 306   2018

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    <p>The patient was a 5-year-old boy who had no medical history. He was referred to us with suspected acute appendicitis and complaints of fever and lower abdominal pain. Although his abdominal pain was intense, rebound tenderness and muscular protection were negative. There were no symptoms of problems in the digestive tract such as vomiting or diarrhea. His blood examination revealed an increase in inflammatory reactions, as indicated by the increased white blood cell count and C-reactive protein levels. Computed tomography (CT) revealed wall thickening of the ascending colon; therefore, we started antibiotic administration after acute enterocolitis was diagnosed. After admission, we performed CT again and found a fatty and dense mass with a swirling structure inside the mass; therefore, we diagnosed the patient as having idiopathic omental torsion. Because the symptoms were relieved, conservative management was continued and the patient was discharged on the fourth day after hospitalization. Omental torsion is a rare condition, particularly seen in children; its classical treatment option is surgery. Although conservative management was successful in this case, there are few reports on it. There are many cases where surgery is performed after an initial diagnosis of acute appendicitis is made owing to the presence of similar symptoms. However, in recent years, because of advances in imaging diagnostic techniques such as CT, more patients are being accurately diagnosed. We believe that if patients are accurately diagnosed, surgery will always be required; however, conservative management is sometimes possible.</p>

    DOI: 10.11164/jjsps.54.2_302

  77. BESNet: Boundary-Enhanced Segmentation of Cells in Histopathological Images Reviewed

    Oda Hirohisa, Roth Holger R., Chiba Kosuke, Sokolic Jure, Kitasaka Takayuki, Oda Masahiro, Hinoki Akinari, Uchida Hiroo, Schnabel Julia A., Mori Kensaku

    MEDICAL IMAGE COMPUTING AND COMPUTER ASSISTED INTERVENTION - MICCAI 2018, PT II   Vol. 11071   page: 228 - 236   2018

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    DOI: 10.1007/978-3-030-00934-2_26

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  78. The efficacy of resection of intrahepatic bile duct stenosis-causing membrane or septum for preventing hepatolithiasis after choledochal cyst excision. Reviewed

    Tanaka Y, Tainaka T, Sumida W, Shirota C, Hinoki A, Murase N, Oshima K, Shirotsuki R, Chiba K, Uchida H

    Journal of pediatric surgery   Vol. 52 ( 12 ) page: 1930-1933   2017.12

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    DOI: 10.1016/j.jpedsurg.2017.08.056

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  79. Intralobar pulmonary sequestration expanding toward the contralateral thorax: two case reports. Reviewed

    Amano H, Fujishiro J, Hinoki A, Uchida H

    BMC surgery   Vol. 17 ( 1 ) page: 110   2017.11

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    DOI: 10.1186/s12893-017-0313-z

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  80. Excellent prognosis of patients with intermediate-risk neuroblastoma and residual tumor postchemotherapy. Reviewed

    Amano H, Uchida H, Tanaka Y, Tainaka T, Mori M, Oguma E, Kishimoto H, Kawashima H, Arakawa Y, Hanada R, Koh K

    Journal of pediatric surgery     2017.11

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    DOI: 10.1016/j.jpedsurg.2017.10.061

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  81. Mesh hiatal reinforcement in laparoscopic Nissen fundoplication for neurologically impaired children is safe and feasible. Reviewed

    Amano H, Tanaka Y, Kawashima H, Deie K, Suzuki K, Fujiogi M, Morita K, Iwanaka T, Uchida H

    Nagoya journal of medical science   Vol. 79 ( 4 ) page: 427-433   2017.11

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    DOI: 10.18999/nagjms.79.4.427

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  82. Comparison of outcomes of thoracoscopic primary repair of gross type C esophageal atresia performed by qualified and non-qualified surgeons. Reviewed

    Tanaka Y, Tainaka T, Sumida W, Shirota C, Murase N, Oshima K, Shirotsuki R, Chiba K, Uchida H

    Pediatric surgery international   Vol. 33 ( 10 ) page: 1081-1086   2017.10

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    DOI: 10.1007/s00383-017-4140-1

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  83. A Novel Laparoscopic Surgery Model with a Device to Expand the Abdominal Working Space in Rats: The Influence of Pneumoperitoneum and Skin Incision Length on Postoperative Inflammatory Cytokines. Reviewed

    Murase N, Tainaka T, Uchida H, Hinoki A, Shirota C, Yokota K, Oshima K, Shirotsuki R, Chiba K, Tanaka Y

    Journal of investigative surgery : the official journal of the Academy of Surgical Research     page: 1-6   2017.9

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    DOI: 10.1080/08941939.2017.1366603

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  84. Review of redo-Kasai portoenterostomy for biliary atresia in the transition to the liver transplantation era. Reviewed

    Sumida W, Uchida H, Tanaka Y, Tainaka T, Shirota C, Murase N, Oshima K, Shirotsuki R, Chiba K

    Nagoya journal of medical science   Vol. 79 ( 3 ) page: 415-420   2017.8

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    DOI: 10.18999/nagjms.79.3.415

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  85. Comparison of single-incision laparoscopic percutaneous extraperitoneal closure (SILPEC) and open repair for pediatric inguinal hernia: a single-center retrospective cohort study of 2028 cases. Reviewed

    Amano H, Tanaka Y, Kawashima H, Deie K, Fujiogi M, Suzuki K, Morita K, Iwanaka T, Uchida H

    Surgical endoscopy     2017.6

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    DOI: 10.1007/s00464-017-5472-6

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  86. New Navigation Surgery for Resection of Lymphatic Malformations Using Indocyanine Green Fluorescence Imaging. Reviewed

    Shirota C, Hinoki A, Takahashi M, Tanaka Y, Tainaka T, Sumida W, Murase N, Oshima K, Shirotsuki R, Chiba K, Morimoto Y, Uchida H

    The American journal of case reports   Vol. 18   page: 529-531   2017.5

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  87. New Navigation Surgery for Resection of Lymphatic Malformations Using Indocyanine Green Fluorescence Imaging

    Shirota Chiyoe, Hinoki Akinari, Takahashi Masataka, Tanaka Yujiro, Tainaka Takahisa, Sumida Wataru, Murase Naruhiko, Oshima Kazuo, Shirotsuki Ryo, Chiba Kosuke, Morimoto Yuji, Uchida Hiroo

    AMERICAN JOURNAL OF CASE REPORTS   Vol. 18   2017.5

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    DOI: 10.12659/AJCR.903465

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  88. Laparoscopic resection of neuroblastomas in low- to high-risk patients without image-defined risk factors is safe and feasible. Reviewed

    Shirota C, Tainaka T, Uchida H, Hinoki A, Chiba K, Tanaka Y

    BMC pediatrics   Vol. 17 ( 1 ) page: 71   2017.3

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    DOI: 10.1186/s12887-017-0826-8

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  89. Two-Stage Thoracoscopic Repair of Long-Gap Esophageal Atresia Using Internal Traction Is Safe and Feasible. Reviewed

    Tainaka T, Uchida H, Tanano A, Shirota C, Hinoki A, Murase N, Yokota K, Oshima K, Shirotsuki R, Chiba K, Amano H, Kawashima H, Tanaka Y

    Journal of laparoendoscopic & advanced surgical techniques. Part A   Vol. 27 ( 1 ) page: 71-75   2017.1

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    DOI: 10.1089/lap.2016.0207

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  90. Pure Laparoscopic Partial Hepatectomy for Hepatoblastoma in an Infant: A Case Report Reviewed

    Amano Hizuru, Kawashima Hiroshi, Tanaka Yujiro, Deie Kyoichi, Fujiogi Michimasa, Suzuki Keisuke, Morita Kaori, Iwanaka Tadashi, Uchida Hiroo

    Journal of the Japanese Society of Pediatric Surgeons   Vol. 53 ( 5 ) page: 1073 - 1078   2017

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    <p>Reports on laparoscopic hepatectomy for malignant tumors in children are few. We present a case of pure laparoscopic partial hepatectomy for hepatoblastoma. A baby girl with Beckwith-Wiedemann syndrome underwent surgical closure of an omphalocele on the sixth day of life. At 4 months, sonographic screening revealed a liver tumor. The alpha-fetoprotein level was 23,060.69 ng/ml, and contrast-enhanced computed tomography revealed a 3.7-cm mass at the left lateral segment of the liver. A biopsy of the mass confirmed the diagnosis of hepatoblastoma (PRETEXT I). After 4 cycles of cisplatin monotherapy, the size of the tumor decreased to 2.7 cm. Laparoscopic partial hepatectomy was performed when she was 6 months old. An umbilical incision was made in an inverted Y shape, allowing for E-Z Access<sup>TM</sup> with a Lap Protector<sup>TM</sup> insertion through which a 1.2-cm trocar was introduced. Two 5-mm working ports were placed lateral to the rectus muscle of either side immediately superior to the umbilicus. After placing a tape around the porta hepatis for the Pringle maneuver in the case of severe bleeding, intraoperative ultrasonography was performed for the identification of the vascular tree and hepatic and portal veins, and the localization of the tumor for accurate and safe resection. Enseal<sup>®</sup> was used to divide the hepatic parenchyma. Branched vessels and ducts were clipped and transected using Enseal<sup>®</sup>. The surgical specimen was extracted through the umbilical incision without enlarging the incision. The patient had an uncomplicated recovery. No recurrence was observed during a 2-year follow-up.</p>

    DOI: 10.11164/jjsps.53.5_1073

  91. Large retroperitoneal immature teratoma leading to renovascular hypertension. Reviewed

    Tainaka T, Ono Y, Yamada Y, Mutoh D, Uchida H

    Pediatrics international : official journal of the Japan Pediatric Society   Vol. 58 ( 12 ) page: 1363-1364   2016.12

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    DOI: 10.1111/ped.13040

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  92. Comparing surgical outcomes of complete thoracoscopic lobectomy for congenital cystic lung disease between neonatal and infantile patients. Reviewed

    Tainaka T, Uchida H, Tanaka Y, Shirota C, Yokota K, Murase N, Oshima K, Shirotsuki R, Chiba K, Hinoki A

    Nagoya journal of medical science   Vol. 78 ( 4 ) page: 447-454   2016.12

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    DOI: 10.18999/nagjms.78.4.447

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  93. Risk factors for thoracic and spinal deformities following lung resection in neonates, infants, and children. Reviewed

    Makita S, Kaneko K, Ono Y, Uchida H

    Surgery today     2016.10

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    DOI: 10.1007/s00595-016-1434-1

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  94. Neonatal Cholestasis in East-Asian patients with Dubin-Johnson Syndrome: Clinical, Pathological and Genetic Features Reviewed International journal

    Takao Togawa, Tokio Sugiura, Tatsuki Mizuochi, Hironori Kusano, Ken Tanikawa, Takahisa Tainaka, Hiroo Uchida, Tomoko Hara, Ryusuke Nambu, Seiichi Kagimoto, Shinji Saitoh

    HEPATOLOGY   Vol. 64   page: 278A - 278A   2016.10

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  95. Classification of biliary atresia in the laparoscopic era. Reviewed

    Nakamura H, Murase N, Koga H, Cazares J, Lane GJ, Uchida H, Yamataka A

    Pediatric surgery international     2016.9

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    DOI: 10.1007/s00383-016-3973-3

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  96. More than one-third of successfully nonoperatively treated patients with complicated appendicitis experienced recurrent appendicitis: Is interval appendectomy necessary? Reviewed

    Tanaka Y, Uchida H, Kawashima H, Fujiogi M, Suzuki K, Takazawa S, Deie K, Amano H, Iwanaka T

    Journal of pediatric surgery     2016.9

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    DOI: 10.1016/j.jpedsurg.2016.09.017

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  97. Long-term outcomes after revision of Kasai portoenterostomy for biliary atresia. Reviewed

    Shirota C, Uchida H, Ono Y, Murase N, Tainaka T, Yokota K, Oshima K, Shirotsuki R, Hinoki A, Ando H

    Journal of hepato-biliary-pancreatic sciences     2016.9

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    DOI: 10.1002/jhbp.395

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  98. Steroid pulse therapy prevents restenosis following balloon dilatation for esophageal stricture. Reviewed

    Yokota K, Uchida H, Tanano A, Shirota C, Tainaka T, Hinoki A, Murase N, Oshima K, Shirotsuki R, Chiba K

    Pediatric surgery international   Vol. 32 ( 9 ) page: 875-9   2016.9

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    DOI: 10.1007/s00383-016-3939-5

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  99. Contraindications and image-defined risk factors in laparoscopic resection of abdominal neuroblastoma. Reviewed

    Tanaka Y, Kawashima H, Mori M, Fujiogi M, Suzuki K, Amano H, Morita K, Arakawa Y, Koh K, Oguma E, Iwanaka T, Uchida H

    Pediatric surgery international   Vol. 32 ( 9 ) page: 845-50   2016.9

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    DOI: 10.1007/s00383-016-3932-z

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  100. Laparoscopic side-to-side pancreaticojejunostomy for chronic pancreatitis in children. Reviewed

    Deie K, Uchida H, Kawashima H, Tanaka Y, Fujiogi M, Amano H, Murase N, Tainaka T

    Journal of minimal access surgery     2016.5

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    DOI: 10.4103/0972-9941.182655

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  101. Left thoracoscopic two-stage repair of tracheoesophageal fistula with a right aortic arch and a vascular ring. Reviewed

    Oshima K, Uchida H, Tainaka T, Tanano A, Shirota C, Yokota K, Murase N, Shirotsuki R, Chiba K, Hinoki A

    Journal of minimal access surgery     2016.5

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    DOI: 10.4103/0972-9941.181771

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  102. Cytomegalovirus (CMV) Monitoring After Liver Transplantation: Comparison of CMV Pp65 Antigenemia Assay with Real-Time PCR Calibrated to WHO International Standard. Reviewed

    Kamei H, Ito Y, Onishi Y, Suzuki M, Imai H, Kurata N, Hori T, Tainaka T, Uchida H, Ogura Y

    Annals of transplantation   Vol. 21   page: 131-6   2016.3

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  103. A feasibility of single-incision laparoscopic percutaneous extraperitoneal closure for treatment of incarcerated inguinal hernia in children: our preliminary outcome and review of the literature. Reviewed

    Murase N, Uchida H, Seki T, Hiramatsu K

    Nagoya journal of medical science   Vol. 78 ( 1 ) page: 19-25   2016.2

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  104. A feasibility of single-incision laparoscopic percutaneous extraperitoneal closure for treatment of incarcerated inguinal hernia in children: our preliminary outcome and review of the literature Reviewed

    Naruhiko Murase, Hiroo Uchida, Takashi Seki, Kiyoshi Hiramatsu

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 78 ( 1 ) page: 19 - 25   2016.2

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    The purpose of this study is to examine the feasibility of single-incision laparoscopic percutaneous extraperitoneal closure (LPEC) for incarcerated inguinal hernia (IIH) repair. 6 single-incision LPEC procedures were performed for IIH repair and 60 procedures were performed for reducible inguinal hernia (RIH) in the same period of time in one hospital. The laparoscope and one pair of grasping forceps were placed through the same umbilical incision. In IIH repair, the herniated organ was gently pulled using the grasping forceps with external manual pressure. If it was difficult to reduce the herniated organ with one pair of forceps, another pair of forceps were inserted through a multi-channel port without extending the umbilical incidion. Using the LPEC needle, the hernia orifice was closed extraperitoneally. We performed a retrospective analysis to compare the outcomes of single-incision LPEC for IIH repair or reducible inguinal hernia. All procedures were completed by single-incision without open conversion. A multi-channel port with another pair of forceps was needed in three cases. The operation time and the length of stay were significantly longer with IIH repair than with RIH repair. There were no major complications and there was no evidence of early recurrence in any patient. In conclusion, single-incision LPEC with a multi-channel port is feasible and safe for IIH repair.

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    Other Link: http://orcid.org/0000-0002-1818-6697

  105. Operative procedures of single-incision laparoscopic repair of pediatric epigastric hernia have become simple and feasible with the use of a novel suture-assisting needle Reviewed International journal

    Kyoichi Deie, Hiroo Uchida, Hiroshi Kawashima, Yujiro Tanaka, Hizuru Amano, Naruhiko Murase, Takahisa Tainaka

    Journal of Pediatric Surgery Case Reports   Vol. 4   page: 22 - 26   2016.1

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    We describe a simple and feasible procedure for single-incision laparoscopic repair of a pediatric epigastric hernia using a novel suture-assisting needle. A multichannel port was inserted through the umbilical vertical incision. After the orifice of the hernia was identified, a suture-assisting needle, which can hold a suture at its tip, with a 2-0 thread was pierced through the skin into one side of the rectus muscle sheath into the abdominal cavity. Next, after releasing the thread, the needle was pulled out to the subcutis and pierced through another side of the rectus muscle sheath. The needle, grasping the thread again, was subsequently pulled out through the abdominal wall outside, and the thread was tied extracorporeally. This knot was buried subcutaneously. Operative procedures of single-incision laparoscopic repair of an epigastric hernia have become simple and feasible with the use of a novel suture-assisting needle with an excellent cosmetic result.

    DOI: 10.1016/j.epsc.2015.11.010

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  106. A Case of Fibrolamellar Hepatocellular Carcinoma Treated by Gemcitabine/Oxaliplatin Chemotherapy (GEMOX Chemotherapy) Preoperatively and Postoperatively Reviewed

    Makita Satoshi, Uchida Hiroo

    Journal of the Japanese Society of Pediatric Surgeons   Vol. 52 ( 6 ) page: 1251 - 1255   2016

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    <p>Fibrolamellar hepatocellular carcinoma (FLHCC) is rare in children. In Japan, there are only six reports of children with FLHCC. We report a case of FLHCC aggressively treated by surgery and chemotherapy. A 12-year-old girl with liver tumor was admitted to our hospital for treatment. FLHCC with lymph node metastases was suspected from various imaging studies and definitively diagnosed as FLHCC by laparotomy biopsy. One cycle of gemcitabine/oxaliplatin (GEMOX) chemotherapy was administered preoperatively because of multiple lymph node metastases. After chemotherapy, her PIVKA-II level decreased but there was no reduction in tumor size. As a result, left hepatectomy and lymphadenectomy were performed. GEMOX chemotherapy was administered as a postoperative adjuvant. After 2 cycles of GEMOX chemotherapy, she developed adhesive ileus and adhesiotomy was performed. Ten cycles of GEMOX chemotherapy were administered after adhesiotomy, and then she was discharged. To date, 3 years after surgery, there is no evidence of recurrence.</p>

    DOI: 10.11164/jjsps.52.6_1251

  107. Laparoscopic-assisted pancreaticoduodenectomy in a child with gastrinoma. Reviewed

    Murase N, Uchida H, Tainaka T, Kawashima H, Tanaka Y, Amano H, Kishimoto H

    Pediatrics international : official journal of the Japan Pediatric Society   Vol. 57 ( 6 ) page: 1196-8   2015.12

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    DOI: 10.1111/ped.12715

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  108. Emergency hepatectomy for hepatic arteriovenous malformation combined with pulmonary hypertension in an infant Reviewed International journal

    Naruhiko Murase, Hiroo Uchida, Akihide Tanano, Chiyoe Shirota, Akinari Hinoki, Takahisa Tainaka, Kazuki Yokota, Kazuo Oshima, Ryo Shirotsuki

    Journal of Pediatric Surgery Case Reports   Vol. 3 ( 12 ) page: 534 - 536   2015.12

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    Patients with hepatic arteriovenous malformations rarely present with pulmonary hypertension. We report the case of a 3-month-old boy who developed severe pulmonary hypertension due to a hepatic arteriovenous malformation. The use of pulmonary vasodilators to treat the patient's pulmonary hypertension worsened his high-output heart failure. This is the first case in which emergency hepatectomy rescued a patient with hepatic arteriovenous malformations who developed pulmonary hypertension.

    DOI: 10.1016/j.epsc.2015.10.017

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  109. Pediatric Surgery. Reviewed

    Iwanaka T, Yamataka A, Uemura S, Okuyama H, Segawa O, Nio M, Yoshizawa J, Yagi M, Ieiri S, Uchida H, Koga H, Sato M, Soh H, Take H, Hirose R, Fukuzawa H, Mizuno M, Watanabe T

    Asian journal of endoscopic surgery   Vol. 8 ( 4 ) page: 390-407   2015.11

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    DOI: 10.1111/ases.12263

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  110. An Easy and Safe Technique for Laparoscopic Pyloromyotomy: Using a Vascular Clamp for Stabilization of the Pylorus. Reviewed

    Fujiogi M, Tanaka Y, Kawashima H, Toma M, Suzuki K, Amano H, Morita K, Uchida H, Iwanaka T

    Journal of laparoendoscopic & advanced surgical techniques. Part A     2015.8

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    DOI: 10.1089/lap.2015.0109

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  111. Influence of surgical intervention on neurodevelopmental outcome in infants with focal intestinal perforation. Reviewed

    Tanaka Y, Uchida H, Kawashima H, Sato K, Takazawa S, Deie K, Masuko T, Kanno K, Shimizu M

    Pediatrics international : official journal of the Japan Pediatric Society   Vol. 57 ( 4 ) page: 687-9   2015.8

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    DOI: 10.1111/ped.12599

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  112. Accessory scrotum with perineal lipoma diagnosed prenatally: case report and review of the literature. Reviewed

    Murase N, Uchida H, Hiramatsu K

    Nagoya journal of medical science   Vol. 77 ( 3 ) page: 501-6   2015.8

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  113. A new modification of laparoscopic percutaneous extraperitoneal closure procedure for repairing pediatric femoral hernias involving a special needle and a wire loop. Reviewed

    Tainaka T, Uchida H, Ono Y, Tanano A, Shirota C, Yokota K, Murase N, Makita S, Shirotsuki R

    Nagoya journal of medical science   Vol. 77 ( 3 ) page: 531-5   2015.8

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  114. Accessory scrotum with perineal lipoma diagnosed prenatally: case report and review of the literature Reviewed

    Naruhiko Murase, Hiroo Uchida, Kiyoshi Hiramatsu

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 77 ( 3 ) page: 501 - 506   2015.8

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    We report a case of accessory scrotum (AS) in the perineal region with peduncular lipoma, diagnosed prenatally. A male fetus of 31 weeks' gestation was referred to our department with a perineal mass. Prenatal ultrasonography and magnetic resonance imaging showed a mass of 1.0 x 1.2 cm located posterior to the scrotum. No other abnormalities were noted during pregnancy. The patient was delivered vaginally at 38 weeks of gestation. On physical examination, a soft peduncular mass with a rugged and pigmented swelling was located between the normally developed scrotum and the anus. There were no specific symptoms or any other associated congenital anomalies. We completely excised the mass at one month of age. A histological examination revealed lipoma, with tissue suggestive of scrotum, so a definite diagnosis of AS was made. AS is a rare congenital anomaly of the scrotum. We review the literature.

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    Other Link: http://orcid.org/0000-0002-1818-6697

  115. A new modification of laparoscopic percutaneous extraperitoneal closure procedure for repairing pediatric femoral hernias involving a special needle and a wire loop Reviewed

    Takahisa Tainaka, Hiroo Uchida, Yasuyuki Ono, Akihide Tanano, Chiyoe Shirota, Kazuki Yokota, Naruhiko Murase, Satoshi Makita, Ryo Shirotsuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 77 ( 3 ) page: 531 - 535   2015.8

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    Femoral hernias are relatively rare in children, and more than half of pediatric femoral hernias are misdiagnosed. A 3-year-old boy was treated for an indirect inguinal hernia at the age of 2, but he exhibited an inguinal bulge one month after the operation. He underwent laparoscopy, and a right femoral hernia was detected. The femoral hernia was laparoscopically repaired via two small incisions: a 1.0-cm umbilical incision for a 3-mm 30 degrees laparoscope and 3-mm grasping forceps and a 5-mm right lateral incision for 3-mm grasping forceps. After the hernia sac had been reflected into the abdominal cavity and resected, the iliopubic tract was sutured to Cooper's ligament using a laparoscopic percutaneous extracorporeal closure (LPEC) needle and 2-0 non-absorbable sutures. Laparoscopy enables the accurate diagnosis of rare and often missed pediatric femoral hernias. Our laparoscopic technique for treating femoral hernias is easy and effective. Although these early results are encouraging, more cases involving longer follow-up periods should be accumulated to confirm the efficacy of our technique.

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    Other Link: http://orcid.org/0000-0002-1818-6697

  116. Long-term outcomes of operative versus nonoperative treatment for uncomplicated appendicitis. Reviewed

    Tanaka Y, Uchida H, Kawashima H, Fujiogi M, Takazawa S, Deie K, Amano H

    Journal of pediatric surgery     2015.7

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    DOI: 10.1016/j.jpedsurg.2015.07.008

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  117. Prophylactic effect of H2 blocker for anastomotic stricture after esophageal atresia repair. Reviewed

    Murase N, Uchida H, Kaneko K, Ono Y, Makita S, Yokota K

    Pediatrics international : official journal of the Japan Pediatric Society   Vol. 57 ( 3 ) page: 461-4   2015.6

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    DOI: 10.1111/ped.12529

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  118. Current Practice and Outcomes of Thoracoscopic Esophageal Atresia and Tracheoesophageal Fistula Repair: A Multi-institutional Analysis in Japan. Reviewed

    Okuyama H, Koga H, Ishimaru T, Kawashima H, Yamataka A, Urushihara N, Segawa O, Uchida H, Iwanaka T

    Journal of laparoendoscopic & advanced surgical techniques. Part A   Vol. 25 ( 5 ) page: 441-4   2015.5

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    DOI: 10.1089/lap.2014.0250

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  119. Effectiveness and safety of immunization with live-attenuated and inactivated vaccines for pediatric liver transplantation recipients. Reviewed

    Kawano Y, Suzuki M, Kawada J, Kimura H, Kamei H, Ohnishi Y, Ono Y, Uchida H, Ogura Y, Ito Y

    Vaccine   Vol. 33 ( 12 ) page: 1440-5   2015.3

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    DOI: 10.1016/j.vaccine.2015.01.075

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  120. Laparoscopic ligation of varicocele testis in children:TANKO operation Reviewed

      Vol. 69 ( 2 ) page: 179 - 185   2015.2

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    DOI: 10.11477/mf.1413205164

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  121. Laparoscopic partial gastrectomy of a huge gastric duplication cyst in an infant. Reviewed

    Takazawa S, Uchida H, Kawashima H, Tanaka Y, Sato K, Jimbo T, Iwanaka T

    Nagoya journal of medical science   Vol. 77 ( 1-2 ) page: 291-6   2015.2

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  122. LAPAROSCOPIC PARTIAL GASTRECTOMY OF A HUGE GASTRIC DUPLICATION CYST IN AN INFANT Reviewed

    Shinya Takazawa, Hiroo Uchida, Hiroshi Kawashima, Yujiro Tanaka, Kaori Sato, Takahiro Jimbo, Tadashi Iwanaka

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 77 ( 1-2 ) page: 291 - 296   2015.2

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    Gastric duplication cyst is a rare anomaly, and most cases are recognized during childhood. Recently, several pediatric cases with small gastric duplication cysts treated by laparoscopic resection have been reported. Here, we describe an infant in whom we successfully performed laparoscopic partial gastrectomy for the treatment of a huge gastric duplication cyst. To the best of our knowledge, this is the largest gastric duplication cyst treated by laparoscopic surgery among infants. We introduce our procedure and some tips.

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    Other Link: http://orcid.org/0000-0002-1818-6697

  123. The umbilical Benz incision for reduced port surgery in pediatric patients. Reviewed

    Amano H, Uchida H, Kawashima H, Deie K, Murase N, Makita S, Yokota K, Tanaka Y

    JSLS : Journal of the Society of Laparoendoscopic Surgeons / Society of Laparoendoscopic Surgeons   Vol. 19 ( 1 ) page: e2014.00238   2015.1

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    DOI: 10.4293/JSLS.2014.00238

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  124. Initial treatment of septated parapneumonic empyema with drainage plus fibrinolytic agents is equally effective as video-assisted thoracoscopic surgery, and is suitable as first-line therapy. Reviewed

    Shirota C, Uchida H

    Translational pediatrics   Vol. 4 ( 1 ) page: 41-4   2015.1

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    DOI: 10.3978/j.issn.2224-4336.2015.02.01

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  125. Laparoendoscopic-assisted Single-site Surgery of an Ileal Duplication Diagnosed Prenatally as an Intraabdominal Cyst Reviewed

    MURASE Naruhiko, UCHIDA Hiroo, HIRAMATSU Kiyoshi, AMEMIYA Takeshi, SEKI Takashi, ARAI Toshiyuki

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)   Vol. 76 ( 3 ) page: 529 - 533   2015

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    A baby girl delivered at the gestational age of 38 week's was referred to our department because of an intraabdominal cyst diagnosed prenatally. There were no specific symptoms after birth. USG revealed a cyst-like structure with gut signature, and CT showed a cystic mass in the abdomen containing air. A preoperative diagnosis of duplication of the alimentary tract or Meckel's diverticulum was made, and a laparoendoscopic single-site surgery was performed when the baby girl was ten months old. An inverted Y-shaped incision was made at the umbilicus, and laparoscopic exploration revealed a cystic mass sharing a common wall and blood supply with the ileum on the mesenteric side. We exteriorized the duplication cyst with normal ileum from the umbilical incision, and performed resection of the segment of the small bowel including the cystic mass. Histopathology revealed that the ileal duplication cyst was lined with gastric epithelium. The postoperative course was uneventful.

    DOI: 10.3919/jjsa.76.529

  126. A New Era of Laparoscopic Revision of Kasai Portoenterostomy for the Treatment of Biliary Atresia. Reviewed

    Murase N, Uchida H, Ono Y, Tainaka T, Yokota K, Tanano A, Shirota C, Shirotsuki R

    BioMed research international   Vol. 2015   page: 173014   2015

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    DOI: 10.1155/2015/173014

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  127. Laparoscopic ligation of varicocele testis in children: Tanko operation Reviewed International journal

    Kawashima H, Tada M, Sato A, Hori Y, Funakoshi D, Uchida H

    Japanese Journal of Clinical Urology   Vol. 69 ( 2 ) page: 179 - 185   2015

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  128. Laparoscopic partial nephrectomy for the treatment of large cystic nephroma in children. Reviewed

    Tanaka Y, Uchida H, Kawashima H, Masuko T, Takazawa S, Deie K, Amano H, Iwanaka T

    Journal of laparoendoscopic & advanced surgical techniques. Part A   Vol. 24 ( 12 ) page: 901-6   2014.12

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    DOI: 10.1089/lap.2014.0222

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  129. Surgical complications, especially gastroesophageal reflux disease, intestinal adhesion obstruction, and diaphragmatic hernia recurrence, are major sequelae in survivors of congenital diaphragmatic hernia. Reviewed

    Yokota K, Uchida H, Kaneko K, Ono Y, Murase N, Makita S, Hayakawa M

    Pediatric surgery international   Vol. 30 ( 9 ) page: 895-9   2014.9

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    DOI: 10.1007/s00383-014-3575-x

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  130. Urethroscopic holmium: YAG laser ablation for acquired posterior urethral diverticulum after repair of anorectal malformations. Reviewed

    Takazawa S, Uchida H, Kawashima H, Tanaka Y, Masuko T, Deie K, Amano H, Kobayashi K, Tada M, Iwanaka T

    Pediatric surgery international   Vol. 30 ( 9 ) page: 945-9   2014.9

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    DOI: 10.1007/s00383-014-3569-8

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  131. Full-thickness small intestine necrosis with midgut volvulus, distributed in a patchy fashion, is reversible with moderate blood flow: resumption of normal function to non-viable intestine. Reviewed

    Amano H, Uchida H, Kawashima H, Tanaka Y, Kishimoto H

    Nagoya journal of medical science   Vol. 76 ( 3-4 ) page: 375-80   2014.8

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  132. Massive hemorrhage after Kasai portoenterostomy in a patient with a congenital extrahepatic portosystemic shunt, malrotation and a double aortic arch: report of a case. Reviewed

    Takazawa S, Uchida H, Kawashima H, Tanaka Y, Sato K, Jimbo T, Deie K, Koiwai K, Nomura K, Iwanaka T

    Surgery today   Vol. 44 ( 8 ) page: 1561-4   2014.8

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    DOI: 10.1007/s00595-013-0605-6

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  133. FULL-THICKNESS SMALL INTESTINE NECROSIS WITH MIDGUT VOLVULUS, DISTRIBUTED IN A PATCHY FASHION, IS REVERSIBLE WITH MODERATE BLOOD FLOW: RESUMPTION OF NORMAL FUNCTION TO NON-VIABLE INTESTINE Reviewed

    Hizuru Amano, Hiroo Uchida, Hiroshi Kawashima, Yujiro Tanaka, Hiroshi Kishimoto

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 76 ( 3-4 ) page: 375 - 380   2014.8

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    Midgut volvulus is a highly life-threatening condition that carries a high risk of short gut syndrome. We report a case of catastrophic neonatal midgut volvulus in which second-look laparotomy revealed apparently non-viable remnant small intestine but with a moderate blood supply. Full-thickness small intestine necrosis was distributed in a patchy fashion, with non-viable and necrotic areas distributed so widely that no portion of the intestine could be resected. A section of full-thickness necrotic intestine preserved at surgery was able to regenerate, and normal function was restored over a period of 1 month. This case indicated that intestinal resumption may be dependent on blood flow. Even when intestinal viability is questionable, preservation enables the chance of regeneration if moderate blood flow is present.

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    Other Link: http://orcid.org/0000-0002-1818-6697

  134. OP-052-7 当施設における小児膵SPT(Solid pseudopapillary tumor)の治療経験(OP-052 膵 IPMN・その他,一般演題,第114回日本外科学会定期学術集会) Reviewed

    牧田 智, 金子 健一朗, 小野 靖之, 横田 一樹, 村瀬 成彦, 内田 広夫

    日本外科学会雑誌   Vol. 115 ( 2 ) page: 408   2014.3

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  135. Thoracoscopic Resection of an Intralobar Pulmonary Sequestration in a Neonate With Heart Failure Reviewed

    Murase Naruhiko, Kaneko Kenichiro, Ono Yasuyuki, Yokota Kazuki, Makita Satoshi, Uchida Hiroo

    Journal of the Japanese Society of Pediatric Surgeons   Vol. 50 ( 5 ) page: 946 - 949   2014

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    High-output heart failure in a neonate due to pulmonary sequestration is rare. We report a case of neonatal heart failure relieved with thoracoscopic resection of an intralobar pulmonary sequestration. A male neonate of 39-week gestational age presented with respiratory distress, chest X-ray and echocardiography revealed high-output heart failure. A computed tomography showed a left lower pulmonary sequestration with venous drainage into the azygos system. Preoperative diagnosis is an extralobar pulmonary sequestration, and high-output heart failure is caused by arteriovenous shunt in the pulmonary sequestration. We intervened with thoracoscopic resection on day-of-life 21. Intraoperative diagnosis is an intralobar pulmonary sequestration. Postoperative course was uneventful, and the patient was discharged on postoperative day 20 without any sign of heart failure.

    DOI: 10.11164/jjsps.50.5_946

  136. Multicenter retrospective comparative study of laparoscopically assisted and conventional anorectoplasty for male infants with rectoprostatic urethral fistula Reviewed

    Yamataka Atsuyuki, Morikawa Yasuhide, Yagi Makoto, Kimura Osamu, Kuroda Tatsuo, Ueno Shigeru, Iwanaka Tadashi, Iwai Jun, Zaizen Yoshio, Koga Hiroyuki, Shimono Ryuichi, Yagi Makoto, Kimura Osamu, Kubota Masayuki, Murase Naruhiko, Kanamori Yutaka, Tanaka Hideaki, Takahashi Masataka, Ikeda Taro, Kubota Akio, Nara Keigo, Satoh Kaori, Amano Hizuru, Takazawa Shinya, Tanaka Yujiro, Uchida Hiroo, Kawashima Hiroshi, Jimbo Takahiro, Fukumoto Kohji, Ueno Shigeru, Ishimaru Tetsuya

    JOURNAL OF PEDIATRIC SURGERY   Vol. 48 ( 12 ) page: 2383-2388   2013.12

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    DOI: 10.1016/j.jpedsurg.2013.08.010

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  137. Laparoscopic excision of urachal remnants is a safe and effective alternative to open surgery in children. Reviewed

    Masuko T, Uchida H, Kawashima H, Tanaka Y, Deie K, Iwanaka T

    Journal of laparoendoscopic & advanced surgical techniques. Part A   Vol. 23 ( 12 ) page: 1016-9   2013.12

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    DOI: 10.1089/lap.2013.0127

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  138. External stabilization for severe tracheobronchomalacia using separated ring-reinforced ePTFE grafts is effective and safe on a long-term basis. Reviewed

    Takazawa S, Uchida H, Kawashima H, Tanaka Y, Masuko T, Deie K, Nagase Y, Iwanaka T

    Pediatric surgery international   Vol. 29 ( 11 ) page: 1165-9   2013.11

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    DOI: 10.1007/s00383-013-3383-8

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  139. Single-incision laparoscopic-assisted appendectomy in children: exteriorization of the appendix is a key component of a simple and cost-effective surgical technique. Reviewed

    Deie K, Uchida H, Kawashima H, Tanaka Y, Masuko T, Takazawa S

    Pediatric surgery international   Vol. 29 ( 11 ) page: 1187-91   2013.11

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    DOI: 10.1007/s00383-013-3373-x

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  140. Complete thoracoscopic versus video-assisted thoracoscopic resection of congenital lung lesions. Reviewed

    Tanaka Y, Uchida H, Kawashima H, Sato K, Takazawa S, Masuko T, Deie K, Iwanaka T

    Journal of laparoendoscopic & advanced surgical techniques. Part A   Vol. 23 ( 8 ) page: 719-22   2013.8

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    DOI: 10.1089/lap.2013.0110

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  141. Successful two-stage thoracoscopic repair of long-gap esophageal atresia using simple internal traction and delayed primary anastomosis in a neonate: report of a case. Reviewed

    Tanaka Y, Uchida H, Kawashima H, Sato K, Takazawa S, Jimbo T, Iwanaka T

    Surgery today   Vol. 43 ( 8 ) page: 906-9   2013.8

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    DOI: 10.1007/s00595-012-0426-z

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  142. Development of a needle driver with multiple degrees of freedom for neonatal laparoscopic surgery. Reviewed

    Ishimaru T, Takazawa S, Uchida H, Kawashima H, Fujii M, Harada K, Sugita N, Mitsuishi M, Iwanaka T

    Journal of laparoendoscopic & advanced surgical techniques. Part A   Vol. 23 ( 7 ) page: 644-8   2013.7

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    DOI: 10.1089/lap.2013.0130

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  143. Long-term survivor of relapsed stage IV malignant rhabdoid tumor of the kidney Reviewed

    Kato Motohiro, Koh Katsuyoshi, Oshima Koichi, Oguma Eiji, Uchida Hiroo, Kishimoto Hiroshi, Kikuchi Akira, Hanada Ryoji

    PEDIATRICS INTERNATIONAL   Vol. 55 ( 2 ) page: 245-248   2013.4

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    DOI: 10.1111/j.1442-200X.2012.03663.x

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  144. Long-term survivor of relapsed stage IV malignant rhabdoid tumor of the kidney. Reviewed

    Kato M, Koh K, Oshima K, Oguma E, Uchida H, Kishimoto H, Kikuchi A, Hanada R

    Pediatrics international : official journal of the Japan Pediatric Society   Vol. 55 ( 2 ) page: 245-8   2013.4

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    DOI: doi: 10.1111/j.1442-200X.2012.03663.x.

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  145. Sacrococcygeal yolk sac tumor developing after teratoma: a clinicopathological study of pediatric sacrococcygeal germ cell tumors and a proposal of the pathogenesis of sacrococcygeal yolk sac tumors. Reviewed

    Yoshida M, Matsuoka K, Nakazawa A, Yoshida M, Inoue T, Kishimoto H, Nakayama M, Takaba E, Hamazaki M, Yokoyama S, Horie H, Tanaka M, Gomi K, Ohama Y, Kigasawa H, Kitano Y, Uchida H, Kanamori Y, Iwanaka T, Tanaka Y

    Journal of pediatric surgery   Vol. 48 ( 4 ) page: 776-81   2013.4

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    DOI: 10.1016/j.jpedsurg.2012.08.028

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  146. Minimally invasive surgery for pediatric cases of large extraovarian teratoma with considerable solid component Reviewed International journal

    Shinya Takazawa, Hiroo Uchida, Hiroshi Kawashima, Yujiro Tanaka, Kaori Sato, Takahiro Jimbo, Takayuki Masuko, Kyoichi Deie, Tadashi Iwanaka

    Journal of Pediatric Surgery Case Reports   Vol. 1 ( 8 ) page: 226 - 229   2013

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    Pediatric patients with large extraovarian teratomas with a significant solid component are usually treated using open surgery because the size of the intracorporeal cavity does not facilitate the manipulation of large tumors. Here, we describe the cases of 3 children who underwent minimally invasive surgery for large extraovarian teratomas (diameter &gt
    10 cm), including 2 cases of retroperitoneal teratoma and 1 case of a thoracic teratoma. All tumors had a large amount of sebaceous material that displaced other surrounding organs. Tumor volumes were reduced by intraoperative needle aspiration using a SAND balloon catheter with a double balloon that is designed to minimize the risk of spillage. Intraoperative needle aspiration of cystic content can provide sufficient working space and facilitates safe separation of the major vessels from the tumor. Treatment of large extraovarian teratomas by minimally invasive surgery involving skin incisions that result in a less noticeable scar, such as a Pfannenstiel incision or axillary incision, can achieve improved cosmetic outcomes. © 2013 The Authors.

    DOI: 10.1016/j.epsc.2013.07.003

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  147. Stapled intestinal anastomosis is a simple and reliable method for management of intestinal caliber discrepancy in children. Reviewed

    Sato K, Uchida H, Tanaka Y, Takazawa S, Jimbo T, Deie K

    Pediatric surgery international   Vol. 28 ( 9 ) page: 893-8   2012.9

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    DOI: 10.1007/s00383-012-3146-y

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  148. Differences in the characteristics and management of pyriform sinus fistula between neonates and young children. Reviewed

    Amano H, Uchida H, Sato K, Kawashima H, Tanaka Y, Takazawa S, Jimbo T

    Pediatric surgery international   Vol. 28 ( 1 ) page: 15-20   2012.1

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    DOI: 10.1007/s00383-011-3008-z

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  149. Sialolipoma of the submandibular gland in a child. Reviewed

    Sato K, Gotoh C, Uchida H, Kawashima H, Yoshida M, Kitano Y, Kishimoto H

    Journal of pediatric surgery   Vol. 46 ( 2 ) page: 408-10   2011.2

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    DOI: 10.1016/j.jpedsurg.2010.09.097

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  150. Inguinal hernia repair in children using single-incision laparoscopic-assisted percutaneous extraperitoneal closure. Reviewed

    Uchida H, Kawashima H, Goto C, Sato K, Yoshida M, Takazawa S, Iwanaka T

    Journal of pediatric surgery   Vol. 45 ( 12 ) page: 2386-9   2010.12

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    DOI: 10.1016/j.jpedsurg.2010.08.037

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  151. Laparoscopic spleen-preserving distal pancreatectomy for solid pseudopapillary tumor with conservation of splenic vessels in a child. Reviewed

    Uchida H, Goto C, Kishimoto H, Kawashima H, Sato K, Yoshida M, Takazawa S

    Journal of pediatric surgery   Vol. 45 ( 7 ) page: 1525-9   2010.7

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    DOI: 10.1016/j.jpedsurg.2010.03.013

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  152. Recurrence of a congenital pancreatic cyst mimicking omental cyst after laparoscopic cyst resection. Reviewed

    Ishimaru T, Uchida H, Yotsumoto K, Gotoh C, Yoshida M, Oguma E, Kishimoto H, Iwanaka T, Kitano Y

    European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie   Vol. 19 ( 1 ) page: 53-4   2009.2

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    DOI: 10.1055/s-2008-1038590

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  153. Residual fistula after laparoscopically assisted anorectoplasty: is it a rare problem? Reviewed

    Uchida H, Iwanaka T, Kitano Y, Kudou S, Ishimaru T, Yotsumoto K, Gotoh C, Yoshida M

    Journal of pediatric surgery   Vol. 44 ( 1 ) page: 278-81   2009.1

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    DOI: 10.1016/j.jpedsurg.2008.10.056

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  154. Seminal vesicle abscesses associated with ipsilateral multicystic dysplastic kidney in an infant. Reviewed

    Fujinaga S, Hirano D, Hara S, Uchida H, Kitano Y, Kobayashi K, Tada M, Someya T, Ohtomo Y, Shimizu T

    Pediatric nephrology (Berlin, Germany)   Vol. 23 ( 9 ) page: 1551-4   2008.9

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    DOI: 10.1007/s00467-008-0839-5

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  155. The laparoscopic approach of neuroblastoma. Reviewed

    Iwanaka T, Kawashima H, Uchida H

    Seminars in pediatric surgery   Vol. 16 ( 4 ) page: 259-65   2007.11

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    DOI: 10.1053/j.sempedsurg.2007.06.008

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  156. Usability Needs to be Improved for Patient Safety Reviewed

    SOMA T, UCHIDA H, HITSUISHI H, TAKEDA S, NAKAJIMA K

    Japan Journal of Medical Informatics   Vol. 27 ( 1 ) page: 29 - 32   2007.5

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    Information and communication technology has been introduced rapidly into health-care field, and can contribute to system complexity and new human errors. Nielsen has defined 5 facets of usability: learnability, efficiency, memorability, errors and satisfaction. The more the usability progress, the more likely patient safety will be achieved, however, there is the trade-off relationship between safety ensuring and efficiency seeking. Technology needs to be designed and improved to support real workflow and care processes.

    DOI: 10.14948/jami.27.29

  157. Midterm follow-up study of high-type imperforate anus after laparoscopically assisted anorectoplasty. Reviewed

    Kudou S, Iwanaka T, Kawashima H, Uchida H, Nishi A, Yotsumoto K, Kaneko M

    Journal of pediatric surgery   Vol. 40 ( 12 ) page: 1923-6   2005.12

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    DOI: 10.1016/j.jpedsurg.2005.08.008

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  158. Complications of laparoscopic surgery in neonates and small infants. Reviewed

    Iwanaka T, Uchida H, Kawashima H, Nishi A, Kudou S, Satake R

    Journal of pediatric surgery   Vol. 39 ( 12 ) page: 1838-41   2004.12

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  159. Infantile intestinal leiomyosarcoma is prognostically favorable despite histologic aggressiveness: case report and literature review. Reviewed

    Yamamoto H, Tsuchiya T, Ishimaru Y, Kisaki Y, Fujino J, Uchida H, Yoshida M, Mori Y, Ikeda H

    Journal of pediatric surgery   Vol. 39 ( 8 ) page: 1257-60   2004.8

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  160. D-lactic acidosis in short-bowel syndrome managed with antibiotics and probiotics. Reviewed

    Uchida H, Yamamoto H, Kisaki Y, Fujino J, Ishimaru Y, Ikeda H

    Journal of pediatric surgery   Vol. 39 ( 4 ) page: 634-6   2004.4

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  161. Umbilicoplasty for large protruding umbilicus accompanying umbilical hernia: a simple and effective technique. Reviewed

    Ikeda H, Yamamoto H, Fujino J, Kisaki Y, Uchida H, Ishimaru Y, Hasumi T, Hamajima A

    Pediatric surgery international   Vol. 20 ( 2 ) page: 105-7   2004.2

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    DOI: 10.1007/s00383-003-1097-z

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  162. Epidermoid cyst: rare testicular tumor in children. Reviewed

    Fujino J, Yamamoto H, Kisaki Y, Ishimaru Y, Uchida H, Mori Y, Nozaki M, Ikeda H

    Pediatric radiology   Vol. 34 ( 2 ) page: 172-4   2004.2

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    DOI: 10.1007/s00247-003-1052-0

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  163. Impact of graft length on surgical damage after intestinal transplantation in rats. Reviewed

    Inoue S, Tahara K, Sakuma Y, Hori T, Uchida H, Hakamada Y, Murakami T, Takahashi M, Kawarasaki H, Hashizume K, Kaneko M, Kobayashi E

    Transplant immunology   Vol. 11 ( 2 ) page: 207-14   2003.4

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    DOI: 10.1016/S0966-3274(03)00008-X

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  164. Impact of graft length on surgical damage after intestinal transplantation in rats Reviewed

    S Inoue, K Tahara, Y Sakuma, T Hori, H Uchida, Y Hakamada, T Murakami, M Takahashi, H Kawarasaki, K Hashizume, M Kaneko, E Kobayashi

    TRANSPLANT IMMUNOLOGY   Vol. 11 ( 2 ) page: 207 - 214   2003.4

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    Background: Intestinal grafts greatly affect nutrition and immunology in the host. The growth of the recipient and incidence of graft-versus-host disease depend on graft length. A larger graft may affect the host immune system, but little is known about how the length of the intestinal graft severely affects surgical intervention. We developed a cervical small bowel transplantation (SBT) rat model that minimized technical variations using a cuff method and studied the effects of graft length on surgical damage in SBT. Materials and methods: We transplanted a whole (70 cm) or partial (15 cm) intestine into a syngeneic rat combination of LEW (MHC haplotype: RT1(1)) to LEW and evaluated changes in perioperative hemodynamics and the endogenous endotoxin level. Natural killer (NK) cell activity in the peripheral blood and the immunologic response of the recipient spleen were also studied. Results: In the whole SBT model, body weight loss was more severe than in the segmental SBT model; the rats in the former model often died, while all in the latter survived indefinitely. The systemic blood pressure markedly decreased in the whole SBT group immediately after reperfusion. The proliferative activity of splenic lymphocytes stimulated by concanavalin A was also more severely inhibited in the former model than in the latter postoperatively. NK cell activity in the whole SBT rats declined more severely than the segmental SBT rats 3 days postoperatively. Conclusion: The longer graft severely induced surgical intervention; and influenced host immunosuppression, resulting in the higher mortality in rats undergoing whole SBT. (C) 2003 Elsevier Science B.V. All rights reserved.

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  165. Increase of bile acid production by tacrolimus in the rat liver. Reviewed

    Mizuta K, Kobayashi E, Uchida H, Hishikawa S, Kawarasaki H

    Transplantation proceedings   Vol. 35 ( 1 ) page: 437-8   2003.2

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  166. Increase of bile acid production by tacrolimus in the rat liver Reviewed

    K Mizuta, E Kobayashi, H Uchida, S Hishikawa, H Kawarasaki

    TRANSPLANTATION PROCEEDINGS   Vol. 35 ( 1 ) page: 437 - 438   2003.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    DOI: 10.1016/S0041-1345(02)03794-6

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  167. Short-course methotrexate and long-term acceptance of fully allogeneic rat cardiac grafts: a possible mechanism of tolerance. Reviewed

    Sakuma Y, Xiu D, Uchida H, Hakamata Y, Takahashi M, Murakami T, Nagai H, Kobayashi E

    Transplant immunology   Vol. 10 ( 1 ) page: 49-54   2002.6

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  168. Short-course methotrexate and long-term acceptance of fully allogeneic rat cardiac grafts: a possible mechanism of tolerance Reviewed

    Sakuma Y, Xiu D, Uchida H, Hakamata Y, Takahashi M, Murakami T, Nagai H, Kobayashi E

    TRANSPLANT IMMUNOLOGY   Vol. 10 ( 1 ) page: 49 - 54   2002.6

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  169. Combined cuff and suture technique for orthotopic whole intestinal transplantation in rats. Reviewed

    Nakao A, Tahara K, Inoue S, Mizuta K, Takeichi T, Uchida H, Tanaka N, Kobayashi E

    Microsurgery   Vol. 22 ( 3 ) page: 85-90   2002

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    DOI: 10.1002/micr.21731

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  170. Chronotherapy of sublethal doses of methotrexate on rats allogeneic heart grafts Reviewed International journal

    Xiu D.R, Sakuma Y, Nagai H, To H, Sugimoto K, Fujimura A, Uchida H, Kobayashi E

    Research Communications in Pharmacology and Toxicology   Vol. 7 ( 1-2 ) page: 77 - 85   2002

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  171. Comparison of efficacy and toxicity between Sandimmune® and Neoral® in the cyclosporine-resistant rat allo-pancreas transplantation Reviewed International journal

    Sakuma Y, Nagai H, Sugimoto K.-I, Fujimura A, Murakami T, Uchida H, Hakamata Y, Takahashi M, Kobayashi E

    Research Communications in Pharmacology and Toxicology   Vol. 7 ( 1-2 ) page: 86 - 94   2002

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  172. Experimental small bowel transplantation using a newborn intestine in rats: IV. Effect of cold preservation on graft neovascularization. Reviewed

    Uchida H, Tahara K, Takizawa T, Inose K, Yashiro T, Hashizume K, Ikeda H, Takahashi M, Kobayashi E

    Journal of pediatric surgery   Vol. 36 ( 12 ) page: 1805-10   2001.12

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    DOI: 10.1053/jpsu.2001.28843

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  173. Experimental small bowel transplantation using a newborn intestine in rats: IV. Effect of cold preservation on graft neovascularization Reviewed

    H Uchida, K Tahara, T Takizawa, K Inose, T Yashiro, K Hashizume, H Ikeda, M Takahashi, E Kobayashi

    JOURNAL OF PEDIATRIC SURGERY   Vol. 36 ( 12 ) page: 1805 - 1810   2001.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:W B SAUNDERS CO  

    Background/Purpose: University of Wisconsin (UW) solution is one of the most superior organ preservation solutions for liver, kidney, and pancreas; however, it still is controversial for intestinal preservation. Here, the authors studied the efficacy of preservation with 2 kinds of solutions, UW and modified TOM (m-TOM) solutions in our experimental newborn intestinal transplantation model. UW solution was used as a standard intracellular and m-TOM solution as an extracellular preservation solution. Lactated ringer (LR) solution was used as a control.
    Methods. Newborn intestine, which were preserved in these solutions for 24 or 48 hours, were transplanted in the subcutaneous spaces of the syngeneic recipients without surgical vascular anastomosis and histologically examined 14 days after grafting. The preserved grafts were evaluated histologically by use of light and electron microscopy just after preservation. The biochemical parameters such as LDH and serotonin also were measured in the supernatants of preservation solutions.
    Results: Fresh newborn grafts were revascularized successfully at a rate of 80% (16 of 20). After 24 hours of preservation, 65% (13 of 20), 75% (15 of 20), and 85% (17 of 20) of the grafts were observed to be revascularized in LR, m-TOM, and UW solutions, respectively. After 48 hours of preservation, 60% (12 of 20), 80% (16 of 20), and 80% (16 of 20) of the grafts also were revascularized in the respective solutions (no statistic difference among the groups). The cold-preservation did not affect the neovascularization of newborn intestine until 48 hours. Histologic findings of the preserved intestine and biochemical analyses showed that UW and m-TOM solutions kept villous architectures of the preserved grafts, however, might be harmful to enterochromaffin cells.
    Conclusion: Long-time preservation of newborn intestine did not interfere with neovascularization and maturation. Copyright (C) 2001 by W.B. Saunders Company.

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  174. High-dose tacrolimus and lengthy survival of the combined rat pancreas/spleen graft in a high-responder combination. Reviewed

    Sakuma Y, Uchida H, Nagai H, Kobayashi E

    Transplant immunology   Vol. 9 ( 1 ) page: 37-42   2001.10

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  175. High-dose tacrolimus and lengthy survival of the combined rat pancreas/spleen graft in a high-responder combination Reviewed

    Y Sakuma, H Uchida, H Nagai, E Kobayashi

    TRANSPLANT IMMUNOLOGY   Vol. 9 ( 1 ) page: 37 - 42   2001.10

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    Pancreas grafts do not survive for lengthy periods, especially in a high-responder rat combination. Recent data indicated that a combined spleen/pancreas graft protects against acute graft rejection and induces donor-specific tolerance. In this study, we performed a combination spleen/pancreas transplantation using high-dose tacrolimus in a high-responder rat combination of DA (RTla) to LEW(RT1(l)) and induced permanent survival in the few recipient rats. In these recipients, there was no difference in the mixed lymphocyte reaction (MLR) of the recipients when compared with that of the naive LEW splenic cells, but MLR inhibition by the serum from the recipients was significantly decreased. We also performed immunoblotting and detected a protein that has an affinity for the anti-DA class antibody. This protein may be an anti-idiotypic antibody and contribute to donor- and tissue-specific tolerance. (C) 2001 Elsevier Science BN. All rights reserved.

    DOI: 10.1016/S0966-3274(01)00049-1

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  176. Green fluorescent protein-transgenic rat: a tool for organ transplantation research. Reviewed

    Hakamata Y, Tahara K, Uchida H, Sakuma Y, Nakamura M, Kume A, Murakami T, Takahashi M, Takahashi R, Hirabayashi M, Ueda M, Miyoshi I, Kasai N, Kobayashi E

    Biochemical and biophysical research communications   Vol. 286 ( 4 ) page: 779-85   2001.8

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    DOI: 10.1006/bbrc.2001.5452

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  177. Experimental small bowel transplantation using newborn intestine in rats: III. Long-term cryopreservation of rat newborn intestine. Reviewed

    Tahara K, Uchida H, Kawarasaki H, Hasizume K, Kobayashi E

    Journal of pediatric surgery   Vol. 36 ( 4 ) page: 602-4   2001.4

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    DOI: 10.1053/jpsu.2001.22295

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  178. Experimental small bowel transplantation using newborn intestine in rats: III. Long-term cryopreservation of rat newborn intestine Reviewed

    K Tahara, H Uchida, H Kawarasaki, K Hasizume, E Kobayashi

    JOURNAL OF PEDIATRIC SURGERY   Vol. 36 ( 4 ) page: 602 - 604   2001.4

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    Background: If long-term organ cryopreservation can be attained, a significant achievement will have been made to address the problem for donor shortage. Fetal intestine has been known to revascularize naturally without vascular anastmosis. The authors have confirmed previously that the newborn intestine also could develop to maturity in the host omentum. Here, the authors examined whether the cryopreserved newborn intestine could revascularize in the syngeneic combination using the 2 different solutions and whether cryopreservation affect their antigenicity in the allogeneic combination.
    Methods: Inbred rat strains of LEW (MHC haplotype; RT1(1)) and BN (RT1(n)) were used. LEW newborn intestinal grafts were stored in RPMI-1640 or University of Wisconsin solution with 10% DEMSO (n = 10 in each group). The grafts were placed into a cold (4 degreesC) preservation solution for 30 minutes and then placed into a freezing chamber and cooled to -80 degreesC at -1 degreesC/min after 12 hours quenched to -180 degreesC in liquid nitrogen for longer than 30 days. Then, the cryopreserved grafts under the 2 different solutions were transplanted syngenicaly (LEW to LEW). The cryopreserved BN grafts also were implanted into the LEW omentum pouch. The allotransplantation was received with a 14-day high-dose course of tacrolimus (0.64 mg/kg, intramuscularly). The grafts were evaluated histologically at 4 weeks after transplantation. Fresh newborn intestines implanted in this syngeneic and allogeneic combination were evaluated as each control group.
    Result: In the syngeneic combination, more than 90% of the mature intestine were obtained. There was no significant difference among the different solution and the fresh group. However, in the allogeneic combination, both fresh and cryo preserved grafts were histologically poor.
    Conclusions: This is the first report showing that long-term cryopreservation was not harmful for neovascularization of newborn intestine. Long-term cryopreservation did not reduce the antigenicity of the newborn intestine.

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  179. Rat auxiliary liver transplantation without portal vein reconstruction: comparison with the portal vein-arterialized model. Reviewed

    Rong Xiu D, Hishikawa S, Sato M, Nagai H, Uchida H, Kobayashi E

    Microsurgery   Vol. 21 ( 5 ) page: 189-95   2001

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  180. Dosing time-dependent pharmacological effects of anti-metabolites for rat cardiac graft. Reviewed

    To H, Xiu DR, Hishikawa S, Uchida H, Sudoh T, Sunaga K, Sugimoto K, Higuchi S, Fujimura A, Kobayashi E

    Research communications in molecular pathology and pharmacology   Vol. 110 ( 5-6 ) page: 319-32   2001

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  181. Orthotopic intestinal transplantation using the cuff method in rats: a histopathological evaluation of the anastomosis. Reviewed

    Nakao A, Ogino Y, Tahara K, Uchida H, Kobayashi E

    Microsurgery   Vol. 21 ( 1 ) page: 12-5   2001

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  182. Simplified method of heterotopic rat heart transplantation using the cuff technique: application to sublethal dose protocol of methotrexate on allograft survival. Reviewed

    Xiu D, Uchida H, To H, Sugimoto K, Kasahara K, Nagai H, Fujimura A, Kobayashi E

    Microsurgery   Vol. 21 ( 1 ) page: 16-21   2001

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  183. Chronopharmacology of oral prednisolone in rats. Reviewed

    Tomizawa N, Uchida H, Xiu DR, To H, Fujimura A, Kobayashi E

    Journal of medicine   Vol. 32 ( 3-4 ) page: 135-51   2001

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  184. Simplified method of heterotopic rat heart transplantation using the cuff technique: Application to sublethal dose protocol of methotrexate on allograft survival Reviewed

    Xiu DR, Uchida H, To H, Sugimoto K, Kasahara K, Nagai H, Fujimura A, Kobayashi E

    MICROSURGERY   Vol. 21 ( 1 ) page: 16 - 21   2001

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  185. Orthotopic intestinal transplantation using the cuff method in rats: A histopathological evaluation of the anastomosis Reviewed

    A Nakao, Y Ogino, K Tahara, H Uchida, E Kobayashi

    MICROSURGERY   Vol. 21 ( 1 ) page: 12 - 15   2001

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    Segmental small intestine transplantation (SIT) in rats, using a cuff technique, has achieved a high success rate. However, there have been few reports on the influence of the foreign body reaction to polyethylene cuff on vessel anastomoses and graft after SIT. This study involves the histopathological examination of the site of cuff anastomosis and grafts in the short- and long-term survival of segmental SIT. The data obtained from the suture anastomosis model also served as a control. One week after heterotopic segmental SIT using the cuff technique, orthotopic continuations were carried out in syngeneic combination. Twenty-five of 30 rats surviving &gt;200 days (83.3%) were examined for vessel anastomosis. All arterial anastomoses were patent, but the portovenous anastomoses in 10 grafts (33%) were totally occluded and were associated with the formation of collateral vessels. Histopathological examination demonstrated good patency of the artery and vein anastomotic site in the short term, but granulation, fibrosis, and neovascularization at the anastomosis site surrounding the cuffs in the long-surviving group. However, the grafts appeared to be intact, with normal features of the villi. On the contrary, the site of the sutured anastomosis in the long-survival rats showed no inflammatory reaction. Although a polyethylene cuff caused foreign body reaction, the graft blood supplies were maintained by collateral vessels. Considering the low mortality and high success rate, polyethylene cuff is good for short-term study and an alternative method for long-term SIT experiments. (C) 2001 Wiley-Liss, Inc.

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  186. Rat auxiliary liver transplantation without portal vein reconstruction: Comparison with the portal vein-arterialized model Reviewed

    Xiu DR, Hishikawa S, Sato M, Nagai H, Uchida H, Kobayashi E

    MICROSURGERY   Vol. 21 ( 5 ) page: 189 - 195   2001

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  187. [Characterization of humoral immunosuppressive factors induced after allogeneic blood transfusion and their application for organ transplantation]. Reviewed

    Uchida H, Tanaka H, Tahara K, Kobayashi E

    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology   Vol. 23 ( 6 ) page: 627-9   2000.12

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  188. Hepatic lymphocyte transplantation in hyperbilirubinemic Gunn rats Reviewed

    Y Yoshida, E Kobayashi, M Nozawa, H Uchida, A Fujimura, T Yamanaka, M Miyata

    EUROPEAN SURGICAL RESEARCH   Vol. 32 ( 4 ) page: 223 - 227   2000.7

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    Hepatic lymphomyeloid cells (HLCs) are thought to contain liver stem cells. We investigated whether HLCs generated enzyme-producing cells in vivo. HLCs from normal Wistar/Shi rats and rats in which liver ischemia was induced using a portal clamp 4 days previously were studed histopathologically and characterized using flow cytometry. Splenic lymphocytes obtained from these animals were compared as a control. The proliferative activity of HLCs and splenic cells from both groups was also tested by stimulation with concanavalin A. HLCs contained a significantly higher number of NK-T cells and OV6+ cells compared with the splenic cells. The HLCs from rats in which liver ischemia was induced tended to have greater proliferative activity than those from normal rats, while the proliferative activity of splenic lymphocytes was impaired by liver ischemia. The HLCs obtained from Wistar/Shi rats with liver ischemia were then injected into hereditary hyperbilirubinemic Gunn rats to determine whether the HLCs generated enzyme-producing cells. After injection of these stimulated HLCs, the titer of serum bilirubin in the recipient rats was markedly reduced over a long time course (6.80 +/- 0.93 to 4.87 +/- 0.22 mg/dl after 1 month and 3.52 +/- 1.33 mg/dl after 6 months). The results of the present study indicate that HLCs have different populations than splenic cells, and ischemia-reperfusion of the liver increased their proliferative activity. HLC transplantation successfully reduced high bilirubin levels over a long time course. Copyright (C) 2000 S. Karger AG, Basel.

    DOI: 10.1159/000008768

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  189. Effect of erythromycin on ischemia-reperfusion injury of liver in rats. Reviewed

    Ohmori M, Miyashita F, Uchida H, Kitoh Y, Tsuruoka S, Harada K, Sugimoto K, Fujimura A, Kobayashi E

    Transplantation proceedings   Vol. 32 ( 4 ) page: 811-4   2000.6

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  190. Effect of erythromycin on ischemia-reperfusion injury of liver in rats Reviewed

    Ohmori M, Miyashita F, Uchida H, Kitoh Y, Tsuruoka S, Harada K, Sugimoto K, Fujimura A, Kobayashi E

    TRANSPLANTATION PROCEEDINGS   Vol. 32 ( 4 ) page: 811 - 814   2000.6

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  191. Mechanisms of immunomodulation induced by blood transfusion: identification of humoral factors. Reviewed

    Uchida H, Tanaka H, Kitoh Y, Yanagisawa K, To H, Tago K, Mizuta K, Fujimura A, Tominaga S, Hashizume K, Kobayashi E

    Transplantation proceedings   Vol. 32 ( 2 ) page: 255-6   2000.3

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  192. Mechanisms of immunomodulation induced by blood transfusion: Identification of humoral factors Reviewed

    H Uchida, H Tanaka, Y Kitoh, K Yanagisawa, H To, K Tago, K Mizuta, A Fujimura, S Tominaga, K Hashizume, E Kobayashi

    TRANSPLANTATION PROCEEDINGS   Vol. 32 ( 2 ) page: 255 - 256   2000.3

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    DOI: 10.1016/S0041-1345(99)00948-3

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  193. Hepatic lymphocyte transplantation in hyperbilirubinemic gunn rats. Reviewed

    Yoshida Y, Kobayashi E, Nozawa M, Uchida H, Fujimura A, Yamanaka T, Miyata M

    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes   Vol. 32 ( 4 ) page: 223-7   2000

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    DOI: 8768

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  194. Detection of membrane-bound and soluble-form MHC class I antigen from rat pancreas/spleen grafts during ongoing rejection. Reviewed

    Kobayashi E, Lord R, Green M, Walker NI, Kamada N, Uchida H, Fujimura A

    Transplantation proceedings   Vol. 31 ( 8 ) page: 3409-13   1999.12

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  195. Detection of membrane-bound and soluble-form MHC class I antigen from rat pancreas/spleen grafts during ongoing rejection Reviewed

    E Kobayashi, R Lord, M Green, NI Walker, N Kamada, H Uchida, A Fujimura

    TRANSPLANTATION PROCEEDINGS   Vol. 31 ( 8 ) page: 3409 - 3413   1999.12

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    DOI: 10.1016/S0041-1345(99)00838-6

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  196. Survival of rats undergoing continuous bile drainage depends on maintenance of circadian rhythm of bile secretion. Reviewed

    Mizuta K, Hishikawa S, Yoshida T, Kobayashi E, Uchida H, Fujimura A, Kawarasaki H, Hashizume K

    Chronobiology international   Vol. 16 ( 6 ) page: 759-65   1999.11

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  197. Chronopharmacology of tacrolimus in rats: toxicity and efficacy in a mouse-to-rat intestinal transplant model and its pharmacokinetic profile. Reviewed

    Uchida H, Kobayashi E, Ogino Y, Mizuta K, To H, Okabe R, Hashizume K, Fujimura A

    Transplantation proceedings   Vol. 31 ( 7 ) page: 2751-3   1999.11

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  198. Cyclosporine inhibits transport of bile acid in rats: comparison of bile acid composition between liver and bile. Reviewed

    Mizuta K, Kobayashi E, Uchida H, Ogino Y, Fujimura A, Kawarasaki H, Hashizume K

    Transplantation proceedings   Vol. 31 ( 7 ) page: 2755-6   1999.11

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  199. Chronotoxicity of mizoribine under repeated administration in the rat. Reviewed

    Hishikawa S, To H, Kobayashi E, Uchida H, Fujimura A

    Transplantation proceedings   Vol. 31 ( 7 ) page: 2765-6   1999.11

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  200. Experimental intestinal transplantation using mouse fetal intestine in the rat: combination effect of FK 506 with cyclophosphamide. Reviewed

    Uchida H, Kobayashi E, Ogino Y, Mizuta K, Hashizume K, Fujimura A

    Transplantation proceedings   Vol. 31 ( 7 ) page: 2799-800   1999.11

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  201. Experimental intestinal transplantation using mouse fetal intestine in the rat: Combination effect of FK 506 with cyclophosphamide Reviewed

    Uchida H, Kobayashi E, Ogino Y, Mizuta K, Hashizume K, Fujimura A

    TRANSPLANTATION PROCEEDINGS   Vol. 31 ( 7 ) page: 2799 - 2800   1999.11

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  202. Chronopharmacology of tacrolimus in rats: Toxicity and efficacy in a mouse-to-rat intestinal transplant model and its pharmacokinetic profile Reviewed

    Uchida H, Kobayashi E, Ogino Y, Mizuta K, To H, Okabe R, Hashizume K, Fujimura A

    TRANSPLANTATION PROCEEDINGS   Vol. 31 ( 7 ) page: 2751 - 2753   1999.11

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  203. Chronotoxicity of mizoribine under repeated administration in the rat Reviewed

    Hishikawa S, To H, Kobayashi E, Uchida H, Fujimura A

    TRANSPLANTATION PROCEEDINGS   Vol. 31 ( 7 ) page: 2765 - 2766   1999.11

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  204. Cyclosporine inhibits transport of bile acid in rats: Comparison of bile acid composition between liver and bile Reviewed

    Mizuta K, Kobayashi E, Uchida H, Ogino Y, Fujimura A, Kawarasaki H, Hashizume K

    TRANSPLANTATION PROCEEDINGS   Vol. 31 ( 7 ) page: 2755 - 2756   1999.11

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  205. Influence of tacrolimus on bile acid and lipid composition in continuously drained bile using a rat model. Reviewed International journal

    KOICHI Mizuta, EIJI Kobayashi, HIROO Uchida, AKIO Fujimura, HIDEO Kawarasaki, KOHEI Hashizume

    Transplant Int   Vol. 12 ( 5 ) page: 316   1999.10

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    DOI: 10.1111/j.1432-2277.1999.tb00616.x

  206. Experimental small bowel transplantation using newborn intestine in rats: II. Revascularization of newborn intestine is independent of vascular endothelial growth factor. Reviewed

    Uchida H, Kobayashi E, Yanagisawa K, Mizuta K, Kitoh Y, Fujimura A, Tominaga S, Kawarasaki H, Hashizume K

    Journal of pediatric surgery   Vol. 34 ( 9 ) page: 1396-400   1999.9

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  207. Experimental small bowel transplantation using newborn intestine in rats: II. Revascularization of newborn intestine is independent of vascular endothelial growth factor Reviewed

    Uchida H, Kobayashi E, Yanagisawa K, Mizuta K, Kitoh Y, Fujimura A, Tominaga S, Kawarasaki H, Hashizume K

    JOURNAL OF PEDIATRIC SURGERY   Vol. 34 ( 9 ) page: 1396 - 1400   1999.9

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  208. Experimental small bowel transplantation using newborn intestine in rats: I. Lipid absorption restored after transplantation of nonvascularized graft. Reviewed

    Uchida H, Yoshida T, Kobayashi E, Mizuta K, Fujimura A, Miyata M, Kawarasaki H, Hashizume K

    Journal of pediatric surgery   Vol. 34 ( 6 ) page: 1007-11   1999.6

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  209. Experimental small bowel transplantation using newborn intestine in rats: I. Lipid absorption restored after transplantation of nonvascularized graft Reviewed

    Uchida H, Yoshida T, Kobayashi E, Mizuta K, Fujimura A, Miyata M, Kawarasaki H, Hashizume K

    JOURNAL OF PEDIATRIC SURGERY   Vol. 34 ( 6 ) page: 1007 - 1011   1999.6

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  210. Chronopharmacology for deoxyspergualin: toxicity and efficacy in the rat. Reviewed

    Uchida H, Kobayashi E, Matsuda K, Mizuta K, Sugimoto K, Kawarasaki H, Hashizume K, Fujimura A

    Transplantation   Vol. 67 ( 9 ) page: 1269-74   1999.5

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  211. Chronopharmacology for deoxyspergualin - Toxicity and efficacy in the rat Reviewed

    Uchida H, Kobayashi E, Matsuda K, Mizuta K, Sugimoto K, Kawarasaki H, Hashizume K, Fujimura A

    TRANSPLANTATION   Vol. 67 ( 9 ) page: 1269 - 1274   1999.5

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  212. Chronopharmacology for deoxyspergualin - Toxicity and efficacy in the rat Reviewed International journal

    H Uchida, E Kobayashi, K Matsuda, K Mizuta, K Sugimoto, H Kawarasaki, K Hashizume, A Fujimura

    TRANSPLANTATION   Vol. 67 ( 9 ) page: 1269 - 1274   1999.5

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:LIPPINCOTT WILLIAMS & WILKINS  

    Background Deoxyspergualin (DSG), a potent immunosuppressive drug, has been clinically used as a rescue therapy for acute graft rejection. However, DSG has severe adverse effects that limits its use. Here, we examined the optimized therapeutic protocol for DSG using chronopharmacological profiles of it.
    Methods. First, a dosing time-dependent difference in the toxicity and efficacy of DSG was determined using a heterotopic heart transplantation model. Second, chronokinetics of DSG were examined to reveal the mechanism for dosing time-dependent differences in the effect.
    Results. In rats treated with DSG at the active period, bone marrow suppression and damage of small intestine were significantly severe. However, no significant difference was found in cardiac allograft survival and pharmacokinetics according to the timing of drug administration.
    Conclusions. The toxicity of DSG varied with the dosing time, whereas its efficacy did not. The chronopharmacological approach may provide merits for immunosuppressive therapy with DSG in clinical organ transplantation.

    DOI: 10.1097/00007890-199905150-00012

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    Other Link: http://orcid.org/0000-0002-1818-6697

  213. Influence of tacrolimus on bile acid and lipid composition in continuously drained bile using a rat model. Comparative study with cyclosporine. Reviewed

    Mizuta K, Kobayashi E, Uchida H, Fujimura A, Kawarasaki H, Hashizume K

    Transplant international : official journal of the European Society for Organ Transplantation   Vol. 12 ( 5 ) page: 316-22   1999

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  214. Effect of immunosuppressants on bile acid kinetics - Comparative study of cyclosporine with tacrolimus Reviewed International journal

    Mizuta K, Kawarasaki H, Hashizume K, Fujimura A, Uchida H, Kobayashi E

    Japanese Pharmacology and Therapeutics   Vol. 27 ( SUPPL. 7 ) page: 93 - 98   1999

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  215. Mechanism of neovascularization in rat newborn organs - Expression of VEGF mRNA and effect of TNP-470 on graft survival Reviewed International journal

    Uchida H, Kobayashi E, Yanagisawa K, Mizuta K, Tominaga S.-I, Hashizume K, Fujimura A

    Biotherapy   Vol. 13 ( 5 ) page: 439 - 441   1999

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  216. Survival of rats undergoing continuous bile drainage depends on maintenance of circadian rhythm of bile secretion Reviewed

    Mizuta K, Hishikawa S, Yoshida T, Kobayashi E, Uchida H, Fujimura A, Kawarasaki H, Hashizume K

    CHRONOBIOLOGY INTERNATIONAL   Vol. 16 ( 6 ) page: 759 - 765   1999

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  217. Experimental small bowel transplantation using newborn intestine in rats - Some immunological studies and considerations for immunological advantage Reviewed

    T Yoshida, H Uchida, E Kobayashi, A Fujimura, M Miyata

    JAPANESE JOURNAL OF TRANSPLANTATION   Vol. 34 ( 4 ) page: 165 - 173   1999

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  218. Do immunosuppressants directly affect neutrophils, resulting in protection of the liver against ischemia-reperfusion injury? Reviewed

    Ohmori M, Kobayashi E, Harada K, Kitoh Y, Mizuta K, Uchida H, Ogino Y, Fujimura A

    Transplantation   Vol. 66 ( 7 ) page: 940-1   1998.10

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  219. Dose-dependent reduction of bile secretion in cyclosporine-treated rats. Reviewed

    Mizuta K, Kobayashi E, Uchida H, Fujimura A, Kawarasaki H, Hashizume K

    Transplantation   Vol. 65 ( 5 ) page: 758-9   1998.3

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  220. Antenatal diagnosis of biliary atresia (type I cyst) at 19 weeks' gestation: differential diagnosis and etiologic implications. Reviewed

    Tsuchida Y, Kawarasaki H, Iwanaka T, Uchida H, Nakanishi H, Uno K

    Journal of pediatric surgery   Vol. 30 ( 5 ) page: 697-9   1995.5

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Books 2

  1. Introduction to Biliary Atresia International journal

    Uchida H, Shirota C, Tainaka T( Role: Joint author)

    Singapore, Springer  2021.4 

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    Responsible for pages:147-156   Language:English Book type:Scholarly book

    DOI: 10.1007/978-981-16-2160-4_22

  2. スタンダード小児内視鏡外科手術 : 押さえておきたい手技のポイント

    山高 篤行, 内田 広夫, 家入 里志, 田口 智章, 奥山 宏臣( Role: Sole author)

    メジカルビュー社  2020  ( ISBN:9784758304672

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    CiNii Books

MISC 14

  1. [THE CURRENT SITUATION AND THE DESIRED FUTURE OF PEDIATRIC MINIMALLY INVASIVE SURGERY]. Invited Reviewed

    Uchida H

    Nihon Geka Gakkai zasshi   Vol. 117 ( 4 ) page: 324-8   2016.7

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  2. 肥厚性幽門狭窄症 (特集 退院から1カ月健診までの新生児対応) -- (見落としてはならない疾患)

    村瀬 成彦, 内田 広夫

    周産期医学   Vol. 46 ( 1 ) page: 63 - 65   2016.1

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    Language:Japanese   Publisher:東京医学社  

    CiNii Books

    Other Link: http://search.jamas.or.jp/link/ui/2016139544

  3. CLINICAL TOPICS : Thoracoscopic Repair of Esophageal Atresia With or Without Tracheoesophageal Fistula, Pursuing Development of an Innovative Treatment

      Vol. 62 ( 1 ) page: 93 - 99   2014.6

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  4. Thoracentesis and chest drainage

    The Journal of pediatric practice   Vol. 73 ( 5 ) page: 785 - 789   2010.5

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  5. Postoperative outcomes of very low birth weight infants with abdominal disorder

      Vol. 98 ( 4 ) page: 401 - 405   2009.4

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    Language:Japanese  

    CiNii Books

  6. Hypertropic pyloric stenosis

    The Journal of pediatric practice   Vol. 71 ( 4 ) page: 633 - 637   2008.4

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  7. 新生児外科--鏡視下検査と鏡視下手術 (特集 周産期画像診断の適応と安全性) -- (新生児の内視鏡検査の適応と安全性)

    工藤 寿美, 岩中 督, 内田 広夫

    周産期医学   Vol. 34 ( 6 ) page: 905 - 908   2004.6

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    Language:Japanese   Publisher:東京医学社  

    CiNii Books

    Other Link: http://search.jamas.or.jp/link/ui/2004284253

  8. 外科的異常の診かた--小児外科より (特集 乳幼児健診のそこが知りたい) -- (外科的問題)

    内田 広夫, 岩中 督

    小児科診療   Vol. 67 ( 6 ) page: 919 - 924   2004.6

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    Language:Japanese   Publisher:診断と治療社  

    CiNii Books

    Other Link: http://search.jamas.or.jp/link/ui/2004282375

  9. 新生仔小腸を用いた実験的小腸移植:血管新生誘導能の消失と再獲得

    田原 和典, 井上 成一朗, 内田 広夫, 金子 隆志, 袴田 陽二, 高橋 将文, 橋都 浩平, 小林 英司

    移植   Vol. 37 ( 5 ) page: 212 - 213   2002.10

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    Language:Japanese   Publisher:(一社)日本移植学会  

  10. 実験的新生仔小腸移植における血管新生のメカニズム

    内田 広夫, 水田 耕一, 小林 英司, 藤村 昭夫, 柳沢 健, 富永 眞一, 橋都 浩平

    移植   Vol. 35 ( 2 ) page: 128 - 128   2000.4

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    Language:Japanese   Publisher:(一社)日本移植学会  

  11. RAT ORGAN TRANSPLANTATION USING CUFF ANASTOMOSIS

    OGINO Yoshinori, UCHIDA Hiroo, DIAN Xiu Rong, KIYOZAKI Hirokazu, TOYAMA Nobuyuki, KOGURE Hiroaki, FUJIMURA Akio, MIYATA Michio, KOBAYASHI Eiji

      Vol. 34 ( 6 ) page: 325 - 347   1999.12

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    Language:English  

    CiNii Books

  12. 輸血により誘導される内因性免疫抑制物質

    小林 英司, 内田 広夫

    日本輸血学会雑誌   Vol. 45 ( 6 ) page: 783 - 783   1999.12

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    Language:Japanese  

    CiNii Books

  13. Chronpharmacology for Deoxyspergalin-Clinical trial in Japan-

      Vol. 34 ( 4 ) page: 208 - 209   1999.8

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    Language:Japanese  

    CiNii Books

  14. 新生仔小腸を用いた実験的小腸移植 免疫学的研究とその考察

    吉田 卓義, 内田 広夫, 小林 英司, 藤村 昭夫, 宮田 道夫

    移植   Vol. 34 ( 4 ) page: 165 - 173   1999.8

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    Language:English   Publisher:(一社)日本移植学会  

    (実験1),胸腺摘除(Tx)や脾臓摘出(Spx)をレシピエントに施した上にデオキシスパーガリン(DSG)を短期間加えアロ新生仔小腸移片の生着率を検討した.レシピエントを4群に分け(Group 1:コントロール,Group 2:DSG単独,Group 3:DSG+Spx,Group 4:DSG+Spx+Tx,グラフトの生着率を検討した.(実験2).新生仔全小腸を含む免疫組織(腸間膜リンパ節(Group 7)及び脾臓(Group 8))を移植し,レシピエントのGVH反応を症状にて判定した.(実験3)成熟グラフトのアロ拒絶反応及びGVH反応を実験1及び2と比較するため,同様のラットの組み合わせにおいて成熟小腸グラフトを頸部に移植するモデルを用いて検討した.本ラット系における新生仔小腸移植は,拒絶反応及びGVH反応の両免疫反応とも移植に有利であった

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Research Project for Joint Research, Competitive Funding, etc. 3

  1. On the job training回避を目的とした小児内視鏡手術統合的術前トレーニングシステム・認定プログラムの確立に関する研究

    2016.9 - 2019.3

    難治性疾患実用化研究事業「Medical Artsの創成に関する研究(外科、がん、看護、リハビリ等の新たな医療技術やソフトウェアの開発)」 

    内田広夫

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    Grant type:Competitive

    1.小児用VRシミュレータの開発
    2.小児用生体質感臓器モデルの開発
    3.トレーニングシステムの手技評価方法の選定
    4.トレーニングシステムのプロトコール作成
    5.トレーニングシステムの有用性の検証

  2. 内視鏡外科手術における熟練技術追体験システムを使用したトレーニングシステムの評価

    2016.9 - 2019.3

    難治性疾患実用化研究事業「Medical Artsの創成に関する研究(外科、がん、看護、リハビリ等の新たな医療技術やソフトウェアの開発)」 

    安藤 英由樹

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    Grant type:Competitive

  3. 極薄シリコン回路と配線・電極形成テキスタイルによるセンシングウェアの開発

    2016.6 - 2019.3

    次世代プリンテッドエレクトロニクス材料・プロセス基盤技術開発 

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    Grant type:Competitive

    極薄シリコン回路チップをフレキシブル回路基板に集積化したフレキシブル無線モジュールと、配線・電極形成テキスタイルを開発し、これらを接続したセンシングウェアの実証試験を行うことを目的とする。

KAKENHI (Grants-in-Aid for Scientific Research) 23

  1. the establish of off the job training for pediatric minimally invasive surgery and automated analysis system of operative technique

    2019.4 - 2022.3

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(B)

    Hiroo Uchida

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    Authorship:Principal investigator 

  2. Development of tracheal stents made from new biodegradable Magnesium alloy

    Grant number:19K22654  2019.6 - 2021.3

    Grant-in-Aid for Challenging Research (Exploratory)

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\6370000 ( Direct Cost: \4900000 、 Indirect Cost:\1470000 )

  3. 体内で分解し残存異物とならない新規マグネシウムデバイス開発と各種疾患治療への応用

    2016.4 - 2019.3

    科学研究費補助金  基盤研究(B)

    内田広夫

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    Authorship:Principal investigator 

    生分解性マグネシウム合金を用いた各種医療デバイスの開発

  4. 超高齢化社会の医療人材不足を克服する次世代医療用ウエアラブルセンサーの新規開発

    2016.4 - 2019.3

    科学研究費補助金 

    内田広夫

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    Authorship:Principal investigator 

    高感度,高耐久性なウエアラブルセンサーの開発

  5. DDS型超分子デバイスを用いた光線力学療法による難治性小児がん根治への試み

    2016.4 - 2018.3

    科学研究費補助金 

    田井中貴久

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    Authorship:Coinvestigator(s) 

    ドラッグデリバリーシステム機能が搭載されたインドシアニングリーンを用いた次世代光線力学治療により浸潤性腫瘍や遠隔転移腫瘍を選択的に治療する新たな治療法の開発

  6. 新規免疫抑制因子MAY-Iの臓器移植治療への応用とその免疫抑制機序

    2002.4 - 2003.3

    科学研究費補助金  基盤研究(B)

    内田広夫

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    Authorship:Principal investigator 

    新規免疫抑制タンパク質MAY-Iはラットinter-alpha-inhibitory H4P heavy chain(H4P)のC末端を含むfragmentであるため、H4Pの組換えタンパク質とH4PでMAY-Iを含まないp-H4Pの組換えタンパク質を作製、精製してその機能を確認した

  7. AI画像解析と鉗子の位置情報を利用した食道閉鎖症手術ナビゲーションシステムの開発

    Grant number:22H03703  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(B)

    内田 広夫

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    Authorship:Principal investigator 

    Grant amount:\17290000 ( Direct Cost: \13300000 、 Indirect Cost:\3990000 )

  8. 横紋筋肉腫メタボローム解析(尿/組織)による診断マーカーとオンコメタボライト探索

    Grant number:22K07911  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    住田 亙, 城田 千代栄, 成田 敦, 牧田 智, 田井中 貴久, 内田 広夫, 高橋 義行, 大澤 毅, 田中 裕次郎, 檜 顕成

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    Authorship:Coinvestigator(s) 

    小児の肉腫のなかで最も頻度が高い横紋筋肉腫を標的とし、その中心代謝に関与する代謝産物(オンコメタボライト)及びその特異的な代謝系を見出すことを目標に、生体内の情報を鋭敏且つ包括的に捉えやすいメタボロミクス(キャピラリー電気泳動質量分析法を中心に)に着目する。第一段階として、尿検体を研究サンプルとして用い、尿中代謝物解析(CE/MS:キャピラリー電気泳動質量分析法を中心にLC/MS: 液体クロマトグラフィー質量分析法)から、代謝物を網羅的に測定し、横紋筋肉腫の中心代謝に特異的な代謝物(オンコメタボライト)の解明を目指す。

  9. 腎芽腫メタボローム解析(尿/組織)による診断マーカーとオンコメタボライト探索

    Grant number:22K07276  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    岡本 眞宗, 城田 千代栄, 成田 敦, 牧田 智, 田井中 貴久, 内田 広夫, 高橋 義行, 大澤 毅, 住田 亙, 田中 裕次郎, 檜 顕成

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    Authorship:Coinvestigator(s) 

    増殖・浸潤・転移などがんの進展における中心代謝と代謝リプログラミングの役割については未だ不明な点が多い。本研究で腎芽腫細胞に特異的な中心代謝に関与する代謝物(オンコメタボライト)を見出す。がん細胞に特異的な代謝系を見出すことにより、正常細胞の代謝系との違いを標的とする新たながんの治療戦略の開発を目指す。腎芽腫患児の尿、腫瘍組織のキャピラリー電気泳動質量分析法を中心とした代謝物解析により、中心代謝に関与するオンコメタボライトを探索し、従来の集学的治療と遺伝子解析だけでは解明できなかった病態解明及び新たな診断治療法の開発に繋げる。

  10. Development of fluorescent probes for diagnosis and treatment of pediatric surgical diseases

    Grant number:21K08640  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s) 

  11. 腎芽腫患児の代謝物網羅解析によるバイオマーカーの探索と創薬への挑戦

    Grant number:21K07805  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    田中 裕次郎, 大澤 毅, 内田 広夫, 檜 顕成, 大島 一夫, 城田 千代栄, 田井中 貴久, 住田 亙, 横田 一樹

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    Authorship:Coinvestigator(s) 

    腎芽腫は小児腎腫瘍の90%を占めるが、全体の約10%に予後不良群を認め、診断バイオマーカーが存在しない。最近メタボロミクス技術の発展により生体内の代謝情報を鋭敏且つ包括的に捉えることが可能となり、様々な癌種において新たなバイオマーカーや病態の解明が進んでいる。腎芽腫においても代謝変動の解明が病因解明や新規治療法の開発に寄与すると考えられるが、その代謝変動に着目した診断マーカーや創薬は前例がない。本研究では腎芽腫をターゲットに尿だけでなく、血液、がん組織を加えた腎芽腫50サンプルの代謝物変動を捉えるメタボローム解析を行い、疾患特異的なバイオマーカー探索とその病態解明に挑む。

  12. Development of a self-supporting ultrathin polymer film (nanosheet) for preventing postoperative suture failure and adhesion

    Grant number:20K08979  2020.4 - 2023.3

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  13. Single cell transcriptome analysis for the intestinal immunity of neonates

    Grant number:18K19503  2018.6 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

    SAWA SHINICHIRO

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    The first aim of this project was to understand composition and function of immune cells in human neonatal gut. We succeeded in setting up single cell transcriptome analysis about human intestinal cells. The second aim was to clarify etiology of neonatal necrotizing colitis (NEC). In NEC patients, intestinal inflammation and tissue necrosis is evident. Using single cell transcriptome analysis, we identified enhanced expression of chemokine receptors and adhesion molecules on T cells in NEC patients.

  14. リンパ管腫のリンパ動態に基づいた光線力学療法による根治の試み

    Grant number:18K08559  2018.4 - 2021.3

    高橋 正貴

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    本研究では、病変特異的な異常リンパ動態を利用して、病変にのみICGを取り込ませ、蛍光イメージングによる局在診断の有用性を検証する。さらに同部位に近赤外光を照射した際に発生する温熱を利用して、リンパ管腫を選択的に治療する光温熱治療の有効性を実証する。
    申請者らはすでに、In vitro実験の検証により、リンパ管腫リンパ管内皮細胞(以下HL-LEC)はICGを取り込み、取り込んだ細胞に近赤外光を照射すると、100%近い細胞の細胞死を誘導することも確認している。また、設定温度が47度以上で確実に細胞死を誘導することを確認している。
    今回、申請者は既に確立した背部皮下リンパ管腫モデルマウスを用いてICGによる蛍光イメージングならびに光温熱治療の治療効果を確認した。背部皮下のリンパ管腫モデルマウスにICGを嚢胞内に打ち込み、近赤外光を照射したところ、病理組織学的に移植片のリンパ管内皮細胞を細胞死に導くことができることを確認した。
    申請書類と同等の進捗状況である。
    申請者らが樹立したリンパ管腫内皮細胞に発光遺伝子(Nano-Lantern)を導入した細胞系を確立している。それを用いて治療効果の検証には、生体イメージングシステム(IVIS&#174;)で、病変の増殖・縮退を経時的に繰り返し観察する。この細胞を用いて作製したモデルマウスにおいては、体外から無侵襲(体毛の剃毛すら不要)かつ短時間(~1 s)に腫瘍局在、サイズ等を検出することができる。一方で超音波イメージングでは50 μmの分解能で、嚢胞や周辺組織を描出できる。定量的な治療効果の検証ができると期待していたが、Nano-Lantern入りHL-LECはIVISで発光せず、定量的な比較が困難であることが判明した。また、モデルマウスの作成に3-4か月を要する。
    現時点では当初の予定通りに進んでいるが、上記事項を考慮して研究を進めていく。
    動物モデルで治療効果の有効性が明らかなので、対照群と比較して量的に有効性を示す必要性がある。
    移植細胞の特殊性と上述した事項から、現時点では定量的評価が困難である。定量的評価を確立させる必要が有るために、HL-LECにfflucやAka-Lucの導入し、In vivo imaging systemを用いて経時的に半定量的評価を行うモデルマウスの作成を予定している。
    それらの体表モデルを用いて体表からの照射を行い、コントロール群との治療効果の比較、照射部位の副作用の比較検討を定量的行う。
    次のステップとして臨床で遭遇する深部体腔内のリンパ管腫病変を想定し、筋肉内病変モデルや後腹膜腫瘍モデルなどのマウスを作製して、本診断・治療法の有効性を確認する。実臨床に即した照射方法として体表照射のみならず、手術時併用を想定に開創時の照射などを検討予定である。

  15. Challenge to Optimize allocation of Pediatric Surgical Resources by using Remote Medical Platform

    Grant number:17H06280  2017.6 - 2020.3

    Grant-in-Aid for Challenging Research (Pioneering)

    Shirota Chiyoe

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    By developing an application and using one-to-many mobile telemedicine to securely link medical sites, we aimed to solve pediatric surgery medical infrastructure and at the same time spread and develop highly specialized telemedicine support. Many doctors can use the application to create a situation where dispersed cases in each region are aggregated in one place (one-to-many remote video conference, image sharing is possible on a smartphone). Can be shared in real time, participate in the consideration of treatment policy, and exchange opinions. We have started to provide highly specialized telemedicine support, which is available 24 hours a day, by securely linking medical fields with desired doctors and hospitals in Japan. The effective use of the system has made it possible to virtually consolidate a specialist with valuable cases.

  16. Highly efficient cancer treatment system combined with a drug-delivery photoabsorbent agent and a tempreature-controled laser system

    Grant number:17H02114  2017.4 - 2020.3

    Morimoto Yuji

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    The applicants have been developing a novel cancer treatment system combined with a drug delivery system light-absorbing agent (ICG lactosome) and photothermal therapy using near-infrared light irradiation system.
    In this project, we have developed a laparoscopic camera with an ultra-compact thermosensor array and established a temperature-controlled, endoscopic laser ablation system.

  17. Establishment of an analytical workflow to elucidate the molecular biology of the pathogenesis of gastrointestinal diseases in neonates

    Grant number:17H04235  2017.4 - 2020.3

    Tanaka Yujiro

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Lymphocytes of 71 resected human bowels were examined using flow cytometry. Type 3 innate lymphoid cells (ILC3), which is known to regulate bowel immunity, was detected in all specimens. However, the percentage of ILC3 was not constant according to the condition of patients, e.g. gestational week and disease. Studying the bowel specimens of emergency laparotomy in human neonates, we also investigated the differences in gene expression between necrotizing enteritis and non-necrotic intestinal perforation. We studied the gene expression on a cell-by-cell basis of about 10,000 cells per each case, so we can assess what cells were specifically showing abnormal responses. To date, there have been no reports of gene expression analysis on a cell-by-cell basis. In necrotizing enteritis, T cells were dominant and pathways concerning inflammation, e.g. MYC targets, mTORC1 signaling, TNFA signaling were activated. In non-necrotic intestinal perforation, innate monocytic cells were the major.

  18. 超高齢化社会の医療人材不足を克服する次世代医療用ウエアラブルセンサーの新規開発

    2016.4 - 2019.3

    日本学術振興会  科学研究費助成事業  萌芽研究

    内田広夫, 檜顕成, 吉田学

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\3510000 ( Direct Cost: \2700000 、 Indirect Cost:\810000 )

    高感度,高耐久性なウエアラブルセンサーの開発

  19. a new wearable multi-lead electrocardiogram measuring system for super-ageing society

    Grant number:16K12957  2016.4 - 2019.3

    UCHIDA HIROO

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\3510000 ( Direct Cost: \2700000 、 Indirect Cost:\810000 )

    To develop a wearable multi-lead electrocardiogram (ECG) measuring system, we fabricated the electrode and wiring by using electrostatic flocking technology on a textile. By using this technology, it was possible to fabricate many electrodes and wiring, simultaneously. The fabricated wiring and electrodes had stretchability and wash resistance properties. To use dry electrodes, it is important to reduce the influence of motion artifacts (MAs). we conducted experiments with a human body to determine the relationship between the contact pressure and the MAs. under the pressures of 1000 Pa , 2000Pa and 4000Pa, the ECG signals under rest and deep breathing conditions were able to be measured without MAs. Finally, we fabricated the wearable ECG measuring system and succeeded in measuring 18-lead ECG signals. The measured ECG waveform is in good agreement with the ECG waveform measured by a commercial system.

  20. 体内で分解し残存異物とならない新規マグネシウムデバイス開発と各種疾患治療への応用

    2016.4 - 2019.3

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    内田広夫, 檜顕成, 花田幸太郎

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\17420000 ( Direct Cost: \13400000 、 Indirect Cost:\4020000 )

    生分解性マグネシウム合金を用いた各種医療デバイスの開発

  21. Development of a new biodegradable magnesium alloy for medical equipment

    Grant number:16H03197  2016.4 - 2019.3

    UCHIDA HIROO

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\17420000 ( Direct Cost: \13400000 、 Indirect Cost:\4020000 )

    We focus on Mg alloy because it is biodegradable, and has excellent biocompatibility. Mg-based medical devices have already been clinically used as vascular stents and orthopaedic screws. However, Mg staples can easily fracture or degrade at the corners of the B-shape after stapling because of their vulnerability to stress corrosion. Another concern is the production of hydrogen gas caused by the rapid corrosion of Mg in physiological environments.
    To address the above challenges, we first redesigned the optimal staple shape to a more rounded form without acute bending points to reduce stress concentrations introduced by stapling and anastomosing. We also developed a novel Mg alloy with sufficiently high ductility to be finely processed to form the shape of a staple and stapled without fracturing. These two patents made us successful in developing Mg alloy staples, and we have confirmed them to be suitable for surgical stapling by rabbit intestinal anastomosis.

  22. Development of Retained Surgical Gauze Detection System before Closing Surgical Incisions.

    Grant number:15K15258  2015.4 - 2018.3

    Hinoki Akinari

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    We found retained surgical gauze while creating several types of surgical gauze detection devices and surgical gauze for detection and detecting eddy current of metallic fiber included in the surgical gauze for detection. Actually, metallic fiber were included in surgical gauze and the change of eddy current was detected from the outside of the body before closing incisions, and the presence or absence of remnant gauze was verified. With respect to silver, the search for degradation kinetics in Both quantitative results of metallic element (silver) and pH change of the extract were very small, and it was judged that the influence of silver itself on the human body was extremely small. Considering biocompatibility, metallic resistance, actual detection distance, and decomposition dynamics in simulated environment of silver in the body, at present, it is necessary to set 4 or 16 circular sections (closed loop windings 3 to 7 times) of silver fibers.

  23. 新規免疫抑制因子MAY-Iの臓器移植治療への応用とその免疫抑制機序

    2002.4 - 2003.3

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    内田広夫, 小林英司, 池田均

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\7000000 ( Direct Cost: \7000000 )

    新規免疫抑制タンパク質MAY-Iはラットinter-alpha-inhibitory H4P heavy chain(H4P)のC末端を含むfragmentであるため、H4Pの組換えタンパク質とH4PでMAY-Iを含まないp-H4Pの組換えタンパク質を作製、精製してその機能を確認した

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Industrial property rights 8

  1. サーモ内視鏡を有する光温熱治療装置

    東海国立大学機構,飛鳥メディカル

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    Date applied:2021.1

    Announcement no:WO 2021/153319  Date announced:2021.8

    Country of applicant:Foreign country   Country of acquisition:Foreign country

  2. 新規検査開発サーバ及び新規検査開発方法

    東海国立大学機構,日立製作所

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    Date applied:2020.2

    Announcement no:2021-128115  Date announced:2021.9

    Country of applicant:Domestic   Country of acquisition:Domestic

  3. 尿中腫瘍マーカーによるがん検出方法、キット及び装置

    東海国立大学機構,日立製作所

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    Date applied:2018.11

    Announcement no:2020-079729  Date announced:2020.5

    Country of applicant:Domestic   Country of acquisition:Domestic

  4. 医療用線状材料

    法人名大,三井金属鉱業

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    Date applied:2018.6

    Announcement no:WO 2018/230415  Date announced:2018.12

    Country of applicant:Foreign country   Country of acquisition:Foreign country

  5. 小児がん検査用尿中代謝物マーカー

    東海国立大学機構,日立製作所

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    Date applied:2018.3

    Announcement no:2019-168319  Date announced:2019.10

    Country of applicant:Domestic   Country of acquisition:Domestic

  6. 小児がんの検査方法

    法人名大

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    Date applied:2016.12

    Announcement no:2018-105674  Date announced:2018.7

    Country of applicant:Domestic   Country of acquisition:Domestic

  7. 生体吸収性ステープル

    法人名大,産業技術総合研究所

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    Date applied:2016.10

    Announcement no:WO 2017/061616  Date announced:2017.4

    Country of applicant:Foreign country   Country of acquisition:Foreign country

  8. 光治療システム

    法人名大,島津製作所

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    Date applied:2016.9

    Announcement no:WO 2018/061201  Date announced:2018.4

    Country of applicant:Foreign country   Country of acquisition:Foreign country

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Teaching Experience (On-campus) 3

  1. 小児外科

    2021

  2. pediatric surgery

    2020

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    pediatric surgery

  3. 小児外科学

    2014