Organization
Institute of Transformative Bio-Molecules Designated assistant professor
Title
Designated assistant professor
Contact information
External link
OISHI Shunsuke
Degree 1
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博士（理学） （ 2012.3 名古屋大学 ）
Research Interests 3
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タンパク質の化学合成
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Peptide Chemistry
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Organic Synthesis
Research Areas 1
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Nanotechnology/Materials / Synthetic organic chemistry / Protein and Peptide Synthesis
Current Research Project and SDGs 1
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ペプチドとタンパク質の化学合成研究
Education 2
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Nagoya University Graduate School, Division of Natural Science
2007.4 - 2012.3
Country： Japan
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Nagoya University Faculty of Science
2003.4 - 2007.3
Country： Japan
Professional Memberships 3
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日本化学会
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The Japanese Peptide Society
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The Society of Synthetic Organic Chemistry, Japan
Awards 2
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Student Presentation Award in the 90th Annual Meeting of the Chemical Society of Japan
2010.4
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Reaxys PhD Prize 2013 Finalist
ELSEVIER
Papers 13
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Trefoil factor 1 suppresses stemness and enhances chemosensitivity of pancreatic cancer
Yamaguchi, J; Kokuryo, T; Yokoyama, Y; Oishi, S; Sunagawa, M; Mizuno, T; Onoe, S; Watanabe, N; Ogura, A; Ebata, T
CANCER MEDICINE Vol. 13 ( 11 ) 2024.6
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Kumarswamyreddy, N; Nakagawa, A; Endo, H; Shimotohno, A; Torii, KU; Bode, JW; Oishi, S
RSC CHEMICAL BIOLOGY Vol. 3 ( 12 ) page： 1422 - 1431 2022.11
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Chemical synthesis of Torenia plant pollen tube attractant proteins by KAHA ligation
Kumarswamyreddy Nandarapu, Reddy Damodara N., Robkis D. Miklos, Kamiya Nao, Tsukamoto Ryoko, Kanaoka Masahiro M., Higashiyama Tetsuya, Oishi Shunsuke, Bode Jeffrey W.
RSC CHEMICAL BIOLOGY Vol. 3 ( 6 ) page： 721 - 727 2022.6
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Regulation of ammonium acquisition and use in Oryza longistaminata ramets under nitrogen source heterogeneity
Kawai Misato, Tabata Ryo, Ohashi Miwa, Honda Haruno, Kamiya Takehiro, Kojima Mikiko, Takebayashi Yumiko, Oishi Shunsuke, Okamoto Satoru, Hachiya Takushi, Sakakibara Hitoshi
PLANT PHYSIOLOGY Vol. 188 ( 4 ) page： 2364 - 2376 2022.3
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Chemical Synthesis of Atomically Tailored SUMO E2 Conjugating Enzymes for the Formation of Covalently Linked SUMO-E2-E3 Ligase Ternary Complexes
Zhang Yinfeng, Hirota Tsuyoshi, Kuwata Keiko, Oishi Shunsuke, Gramani Subramanian G., Bode Jeffrey W.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 141 ( 37 ) page： 14742 - 14751 2019.9
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Acceptor-Controlled Transfer Dehydration of Amides to Nitriles
Okabe Hiroyuki, Naraoka Asuka, Isogawa Takahiro, Oishi Shunsuke, Naka Hiroshi
ORGANIC LETTERS Vol. 21 ( 12 ) page： 4767 - 4770 2019.6
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Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth
Oshima Tsuyoshi, Niwa Yoshimi, Kuwata Keiko, Srivastava Ashutosh, Hyoda Tomoko, Tsuchiya Yoshiki, Kumagai Megumi, Tsuyuguchi Masato, Tamaru Teruya, Sugiyama Akiko, Ono Natsuko, Zolboot Norjin, Aikawa Yoshiki, Oishi Shunsuke, Nonami Atsushi, Arai Fumio, Hagihara Shinya, Yamaguchi Junichiro, Tama Florence, Kunisaki Yuya, Yagita Kazuhiro, Ikeda Masaaki, Kinoshita Takayoshi, Kay Steve A., Itami Kenichiro, Hirota Tsuyoshi
SCIENCE ADVANCES Vol. 5 ( 1 ) 2019.1
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Catalytic hydrogenation of unactivated amides enabled by hydrogenation of catalyst precursor Invited Reviewed
Miura, Takashi; Held, Ingmar E; Oishi, Shunsuke; Naruto, Masayuki; Saito, Susumu
Tetrahedron letters Vol. 54 ( 21 ) page： 2674 - 2678 2013.5
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Yang, You; Oishi, Shunsuke; Martin, Christopher E; Seeberger, Peter H
Journal of the American Chemical Society Vol. 135 ( 16 ) page： 6262 - 6271 2013.4
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Reaction of an "invisible" frustrated N/B Lewis pair with dihydrogen Reviewed International coauthorship
Schwendemann, Sina; Oishi, Shunsuke; Saito, Susumu; Fröhlich, Roland; Kehr, Gerald; Erker, Gerhard
Chemistry, an Asian journal Vol. 8 ( 1 ) page： 212 - 217 2013.1
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Oishi, Shunsuke; Saito, Susumu
Angewandte Chemie Vol. 51 ( 22 ) page： 5395 - 5399 2012.5
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Selective N-Alkylation of Amines with Alcohols by Using Non-Metal-Based Acid--Base Cooperative Catalysis Invited Reviewed
Du, Ya; Oishi, Shunsuke; Saito, Susumu
Chemistry--A European Journal Vol. 17 ( 44 ) page： 12262 - 12267 2011.9
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Oishi, Shunsuke; Yoshimoto, Junichi; Saito, Susumu
Journal of the American Chemical Society Vol. 131 ( 25 ) page： 8748 - 8749 2009.7
KAKENHI (Grants-in-Aid for Scientific Research) 4
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Grant number：24H00855 2024.4 - 2027.3
科学研究費助成事業 学術変革領域研究(B)
西村 岳志, 大石 俊輔
Authorship：Coinvestigator(s)
植物は重力や光などの環境刺激を受け、自身をより環境に適した形へ柔軟に変化させる。しかし、環境刺激がそれぞれの細胞の形や成長を制御するシグナル伝達は不明な点が多い。申請者は、シロイヌナズナを用いた重力シグナル伝達の研究で、重力シグナルタンパク質は膜交通の制御タンパク質と相互作用し、オーキシン極性輸送を制御することを明らかにした。本研究計画では、分子生物学的および細胞生物学的手法と、構成生物学的手法を組み合わせることで、どの様に植物が環境刺激を受けて細胞極性を再構築するか明らかにすることを目指す。
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植物シグナル伝達タンパク質の化学合成研究とタンパク質プローブ開発への応用
Grant number：22K05312 2022.4 - 2025.3
科学研究費助成事業 基盤研究(C)
大石 俊輔
Authorship：Principal investigator
Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）
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Grant number：19K15705 2019.4 - 2022.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
Authorship：Principal investigator
Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）
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Efficient assembly of multiple peptide segment for total chemical protein synthesis
Grant number：16K05842 2016.4 - 2019.3
Oishi Shunsuke
Authorship：Principal investigator
Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）
We have developed efficient assembly of three peptide fragments by using peptide ligation reactions. Among many protein targets, we selected cysteine-rich proteins, which are difficult to produce with over-expression due to protein aggregation and important class of proteins in biology research. We studied total chemical synthesis of several cysteine rich proteins. And we are planning to apply them to biology research with collaboration with biologists.