Updated on 2024/04/02

写真a

 
SAKAMOTO Kazuma
 
Organization
Institute for Glyco-core Research Associate professor
Graduate School of Medicine Associate professor
Graduate School
Graduate School of Medicine
Title
Associate professor
Contact information
メールアドレス
External link

Degree 1

  1. 博士(医学) ( 2011.3   名古屋大学 ) 

Research Interests 5

  1. Autophagy

  2. Regeneration

  3. Axon

  4. 糖鎖

  5. 神経回路形成

Research Areas 5

  1. Life Science / Medical biochemistry

  2. Life Science / Pathological biochemistry

  3. Life Science / Pathophysiologic neuroscience

  4. Life Science / Neuroscience-general

  5. Life Science / Function of nervous system

Current Research Project and SDGs 3

  1. 神経軸索再生阻害のメカニズム

  2. 糖鎖が制御する神経回路の機能解析

  3. 疾病糖鎖マーカーの同定

Research History 8

  1. Nagoya University   Institute for Glyco-core Research   Associate professor

    2021.1

  2. Nagoya University   Associate professor

    2019.10

  3. Nagoya University   Associate professor

    2019.10

  4. 名古屋大学大学院医学系研究科   附属神経疾患・腫瘍分子医学研究センター 先端応用医学部門   助教

    2016.5 - 2019.9

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    Country:Japan

  5. Nagoya University

    2013.4 - 2016.4

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    Country:Japan

  6. 名古屋大学大学院医学系研究科   生物化学講座   研究員

    2012.4 - 2013.3

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    Country:Japan

  7. 財団法人・精神・神経科学振興財団   リサーチ・レジデント

    2011.10 - 2012.3

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    Country:Japan

  8. 名古屋大学大学院医学系研究科   生物化学講座   研究員

    2011.4 - 2011.9

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    Country:Japan

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Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    2007.4 - 2011.3

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    2001.4 - 2007.3

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    Country: Japan

Professional Memberships 3

  1. 日本生化学会

  2. 日本神経科学会

  3. 日本糖質学会

Awards 4

  1. JB論文賞

    2022   日本生化学会  

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    Award type:Honored in official journal of a scientific society, scientific journal 

  2. 日本糖質学会奨励賞

    2020   日本糖質学会  

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    Award type:Award from Japanese society, conference, symposium, etc. 

  3. 第6回領域班会議 最優秀発表賞

    2014   新学術領域研究「神経糖鎖生物学」  

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    Award type:Award from Japanese society, conference, symposium, etc. 

  4. つるま賞

    2007   名古屋大学医学部医学科  

 

Papers 32

  1. Towards the in vivo identification of protein-protein interactions Invited Reviewed

    Suzuki Yuji, Kadomatsu Kenji, Sakamoto Kazuma

    JOURNAL OF BIOCHEMISTRY   Vol. 173 ( 6 ) page: 413 - 415   2023.5

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jb/mvad013

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  2. Glypican-2 defines age-dependent axonal response to chondroitin sulfate. Reviewed

    Ouchida J, Ozaki T, Segi N, Suzuki Y, Imagama S, Kadomatsu K, Sakamoto K.

    EXPERIMENTAL NEOROLOGY   Vol. 366   page: 114444   2023

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.expneurol.2023.114444.

  3. Midkine Interaction with Chondroitin Sulfate Model Synthetic Tetrasaccharides and Their Mimetics: The Role of Aromatic Interactions Reviewed International coauthorship

    Garcia-Jimenez Maria Jose, Gil-Caballero Sergio, Maza Susana, Corzana Francisco, Juarez-Vicente Francisco, Miles Jonathan R., Sakamoto Kazuma, Kadomatsu Kenji, Garcia-Dominguez Mario, de Paz Jose L., Nieto Pedro M.

    CHEMISTRY-A EUROPEAN JOURNAL   Vol. 27 ( 48 ) page: 12395 - 12409   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/chem.202101674

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  4. Dermatan sulfate is an activating ligand of anaplastic lymphoma kinase. Reviewed

    Machino M, Gong Y, Ozaki T, Suzuki Y, Watanabe E, Imagama S, Kadomatsu K, Sakamoto K

    JOURNAL OF BIOCHEMISTRY     2021.7

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jb/mvab085

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  5. Axonal Regeneration by Glycosaminoglycan Invited Reviewed

    Sakamoto Kazuma, Ozaki Tomoya, Kadomatsu Kenji

    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY   Vol. 9   page: 702179   2021.6

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fcell.2021.702179

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  6. Enoxaparin promotes functional recovery after spinal cord injury by Reviewed

    Ito Sadayuki, Ozaki Tomoya, Morozumi Masayoshi, Imagama Shiro, Kadomatsu Kenji, Sakamoto Kazuma

    EXPERIMENTAL NEUROLOGY   Vol. 340   page: 113679   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.expneurol.2021.113679

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  7. Type IIa RPTPs and Glycans: Roles in Axon Regeneration and Synaptogenesis Invited Reviewed

    Sakamoto Kazuma, Ozaki Tomoya, Suzuki Yuji, Kadomatsu Kenji

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 22 ( 11 )   2021.6

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms22115524

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  8. Identification of PTPR sigma-interacting proteins by proximity-labelling assay Reviewed

    Gong Yuanhao, Abudureyimu Shaniya, Kadomatsu Kenji, Sakamoto Kazuma

    JOURNAL OF BIOCHEMISTRY   Vol. 169 ( 2 ) page: 187 - 194   2021.2

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jb/mvaa141

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  9. Glycan sulfation patterns define autophagy flux at axon tip via PTPR sigma-cortactin axis Reviewed International coauthorship

    Sakamoto Kazuma, Ozaki Tomoya, Ko Yen-Chun, Tsai Cheng-Fang, Gong Yuanhao, Morozumi Masayoshi, Ishikawa Yoshimoto, Uchimura Kenji, Nadanaka Satomi, Kitagawa Hiroshi, Zulueta Medel Manuel L., Bandaru Anandaraju, Tamura Jun-ichi, Hung Shang-Cheng, Kadomatsu Kenji

    NATURE CHEMICAL BIOLOGY   Vol. 15 ( 7 ) page: 699 - +   2019.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41589-019-0274-x

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  10. Generation and characterization of antagonistic anti-human interleukin (IL)-18 monoclonal antibodies with high affinity: Two types of monoclonal antibodies against full-length IL-18 and the neoepitope of inflammatory caspase-cleaved active IL-18 Reviewed

    Nariai Yuko, Kamino Hiroki, Obayashi Eiji, Kato Hiroaki, Sakashita Gyosuke, Sugiura Tomoko, Migita Kiyoshi, Koga Tomohiro, Kawakami Atsushi, Sakamoto Kazuma, Kadomatsu Kenji, Nakakido Makoto, Tsumoto Kouhei, Urano Takeshi

    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 663   page: 71 - 82   2019.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.abb.2019.01.001

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  11. Midkine Promotes Atherosclerotic Plaque Formation Through Its Pro-Inflammatory, Angiogenic and Anti-Apoptotic Functions in Apolipoprotein E-Knockout Mice Reviewed

    Takemoto Yoshio, Horiba Mitsuru, Harada Masahide, Sakamoto Kazuma, Takeshita Kyosuke, Murohara Toyoaki, Kadomatsu Kenji, Kamiya Kaichiro

    CIRCULATION JOURNAL   Vol. 82 ( 1 ) page: 19 - 27   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-17-0043

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  12. Neurocan, an extracellular chondroitin sulfate proteoglycan, stimulates neuroblastoma cells to promote malignant phenotypes

    Su Zhendong, Kishida Satoshi, Tsubota Shoma, Sakamoto Kazuma, Cao Dongliang, Kiyonari Shinichi, Ohira Miki, Kamijo Takehiko, Narita Atsushi, Xu Yinyan, Takahashi Yoshiyuki, Kadomatsu Kenji

    ONCOTARGET   Vol. 8 ( 63 ) page: 106296 - 106310   2017.12

  13. Mechanisms of axon regeneration: The significance of proteoglycans Invited Reviewed

    Sakamoto Kazuma, Kadomatsu Kenji

    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS   Vol. 1861 ( 10 ) page: 2435 - 2441   2017.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbagen.2017.06.005

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  14. Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue Reviewed International coauthorship

    Scilabra Simone D., Yamamoto Kazuhiro, Pigoni Martina, Sakamoto Kazuma, Mueller Stephan A., Papadopoulou Alkmini, Lichtenthaler Stefan F., Troeberg Linda, Nagase Hideaki, Kadomatsu Kenji

    MATRIX BIOLOGY   Vol. 59   page: 69 - 79   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.matbio.2016.07.004

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  15. Mechanisms of axon regeneration and its inhibition: Roles of sulfated glycans Invited Reviewed

    Kadomatsu Kenji, Sakamoto Kazuma

    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 558   page: 36 - 41   2014.9

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    Authorship:Last author   Language:English  

    DOI: 10.1016/j.abb.2014.06.009

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  16. Therapeutic potential of midkine in cardiovascular disease Invited Reviewed

    Kadomatsu Kenji, Bencsik Peter, Goerbe Aniko, Csonka Csaba, Sakamoto Kazuma, Kishida Satoshi, Ferdinandy Peter

    BRITISH JOURNAL OF PHARMACOLOGY   Vol. 171 ( 4 ) page: 936 - 944   2014.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/bph.12537

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  17. Keratan sulfate expression in microglia is diminished in the spinal cord in experimental autoimmune neuritis Reviewed

    Matsui H., Ohgomori T., Natori T., Miyamoto K., Kusunoki S., Sakamoto K., Ishiguro N., Imagama S., Kadomatsu K.

    CELL DEATH & DISEASE   Vol. 4   2013.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/cddis.2013.479

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  18. Ablation of Keratan Sulfate Accelerates Early Phase Pathogenesis of ALS Reviewed

    Hirano Kenichi, Ohgomori Tomohiro, Kobayashi Kazuyoshi, Tanaka Fumiaki, Matsumoto Tomohiro, Natori Takamitsu, Matsuyama Yukihiro, Uchimura Kenji, Sakamoto Kazuma, Takeuchi Hideyuki, Hirakawa Akihiro, Suzumura Akio, Sobue Gen, Ishiguro Naoki, Imagama Shiro, Kadomatsu Kenji

    PLOS ONE   Vol. 8 ( 6 ) page: e66969   2013.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0066969

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  19. Minocycline selectively inhibits M1 polarization of microglia Reviewed

    Kobayashi K., Imagama S., Ohgomori T., Hirano K., Uchimura K., Sakamoto K., Hirakawa A., Takeuchi H., Suzumura A., Ishiguro N., Kadomatsu K.

    CELL DEATH & DISEASE   Vol. 4   2013.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/cddis.2013.54

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  20. Midkine Promotes Neuroblastoma through Notch2 Signaling Reviewed

    Kishida Satoshi, Mu Ping, Miyakawa Shin, Fujiwara Masatoshi, Abe Tomoyuki, Sakamoto Kazuma, Onishi Akira, Nakamura Yoshikazu, Kadomatsu Kenji

    CANCER RESEARCH   Vol. 73 ( 4 ) page: 1318 - 1327   2013.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/0008-5472.CAN-12-3070

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  21. Midkine in the pathology of cancer, neural disease, and inflammation Invited Reviewed

    Sakamoto Kazuma, Kadomatsu Kenji

    PATHOLOGY INTERNATIONAL   Vol. 62 ( 7 ) page: 445 - 455   2012.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1440-1827.2012.02815.x

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  22. Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms Reviewed

    Sakai Kiyoshi, Yamamoto Akihito, Matsubara Kohki, Nakamura Shoko, Naruse Mami, Yamagata Mari, Sakamoto Kazuma, Tauchi Ryoji, Wakao Norimitsu, Imagama Shiro, Hibi Hideharu, Kadomatsu Kenji, Ishiguro Naoki, Ueda Minoru

    JOURNAL OF CLINICAL INVESTIGATION   Vol. 122 ( 1 ) page: 80 - 90   2012.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1172/JCI59251

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  23. Keratan Sulfate Restricts Neural Plasticity after Spinal Cord Injury Reviewed

    Imagama Shiro, Sakamoto Kazuma, Tauchi Ryoji, Shinjo Ryuichi, Ohgomori Tomohiro, Ito Zenya, Zhang Haoqian, Nishida Yoshihiro, Asami Nagamasa, Takeshita Sawako, Sugiura Nobuo, Watanabe Hideto, Yamashita Toshihide, Ishiguro Naoki, Matsuyama Yukihiro, Kadomatsu Kenji

    JOURNAL OF NEUROSCIENCE   Vol. 31 ( 47 ) page: 17091 - 17102   2011.11

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1523/JNEUROSCI.5120-10.2011

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  24. Keratan Sulfate in Neuronal Network Reconstruction Invited Reviewed

    Sakamoto Kazuma, Kadomatsu Kenji

    TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY   Vol. 23 ( 133 ) page: 212 - 220   2011.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4052/tigg.23.212

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  25. Premature Ligand-Receptor Interaction during Biosynthesis Limits the Production of Growth Factor Midkine and Its Receptor LDL Receptor-related Protein 1 Reviewed International coauthorship

    Sakamoto Kazuma, Bu Guojun, Chen Sen, Takei Yoshifumi, Hibi Kenji, Kodera Yasuhiro, McCormick Lynn M., Nakao Akimasa, Noda Masaharu, Muramatsu Takashi, Kadomatsu Kenji

    JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 286 ( 10 ) page: 8405 - 8413   2011.3

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M110.176479

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  26. Basigin/CD147 Promotes Renal Fibrosis after Unilateral Ureteral Obstruction Reviewed

    Kato Noritoshi, Kosugi Tomoki, Sato Waichi, Ishimoto Takuji, Kojima Hiroshi, Sato Yuka, Sakamoto Kazuma, Maruyama Shoichi, Yuzawa Yukio, Matsuo Seiichi, Kadomatsu Kenji

    AMERICAN JOURNAL OF PATHOLOGY   Vol. 178 ( 2 ) page: 572 - 579   2011.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ajpath.2010.10.009

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  27. N-Acetylglucosamine 6-O-Sulfotransferase-1-Deficient Mice Show Better Functional Recovery after Spinal Cord Injury Reviewed

    Ito Zenya, Sakamoto Kazuma, Imagama Shiro, Matsuyama Yukihiro, Zhang Haoqian, Hirano Kenichi, Ando Kei, Yamashita Toshihide, Ishiguro Naoki, Kadomatsu Kenji

    JOURNAL OF NEUROSCIENCE   Vol. 30 ( 17 ) page: 5937 - 5947   2010.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1523/JNEUROSCI.2570-09.2010

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  28. DRR1 is expressed in the developing nervous system and downregulated during neuroblastoma carcinogenesis Reviewed

    Asano Yoshizumi, Kishida Satoshi, Mu Ping, Sakamoto Kazuma, Murohara Toyoaki, Kadomatsu Kenji

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 394 ( 3 ) page: 829 - 835   2010.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2010.03.085

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  29. The E-Selectin Ligand Basigin/CD147 Is Responsible for Neutrophil Recruitment in Renal Ischemia/Reperfusion Reviewed

    Kato Noritoshi, Yuzawa Yukio, Kosugi Tomoki, Hobo Akinori, Sato Waichi, Miwa Yuko, Sakamoto Kazuma, Matsuo Seiichi, Kadomatsu Kenji

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   Vol. 20 ( 7 ) page: 1565 - 1576   2009.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1681/ASN.2008090957

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  30. Transforming growth factor-beta 1 upregulates keratan sulfate and chondroitin sulfate biosynthesis in microglias after brain injury Reviewed

    Yin Jiarong, Sakamoto Kazuma, Zhang Haoqian, Ito Zenya, Imagama Shiro, Kishida Satoshi, Natori Takamitsu, Sawada Makoto, Matsuyama Yukihiro, Kadomatsu Kenji

    BRAIN RESEARCH   Vol. 1263   page: 10 - 22   2009.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.brainres.2009.01.042

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  31. Axonal regeneration and keratan sulfate Reviewed

    Kadomatsu Kenji, Imagama Shiro, Ito Zenya, Sakamoto Kazuma, Matsuyama Yukihiro

    NEUROSCIENCE RESEARCH   Vol. 61   page: S17 - S17   2008

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    Language:English   Publishing type:Research paper (scientific journal)  

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  32. Midkine and LDL-receptor-related protein 1 contribute to the anchorage-independent cell growth of cancer cells Reviewed International coauthorship

    Chen Sen, Bu Guojun, Takei Yoshifumi, Sakamoto Kazuma, Ikematsu Shinya, Muramatsu Takashi, Kadomatsu Kenji

    JOURNAL OF CELL SCIENCE   Vol. 120 ( 22 ) page: 4009 - 4015   2007.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1242/jcs.013946

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Books 6

  1. Glycoforum グリコサミノグリカンによるdystrophic endball形成機構

    坂元一真( Role: Sole author ,  Proteoglycan)

    生化学工業  2022 

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    Book type:Scholarly book

  2. 「神経回路再生ならびに小児がん神経芽腫の研究」

    坂元一真、尾崎智也、坪田庄真、郷詩織、鈴木佑治、門松健治( Role: Joint author ,  マイクロ・ナノメカトロニクス研究 3章)

    丸善プラネット  2022 

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    Language:Japanese Book type:Textbook, survey, introduction

  3. 硫酸化糖鎖によるDystrophic endball形成機構

    坂元一真 門松健治( Role: Joint author)

    日本生化学会  2020 

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    Language:Japanese Book type:Textbook, survey, introduction

  4. 神経軸索におけるオートファジーとその破綻

    坂元一真 門松健治( Role: Joint author)

    日本生化学会  2018 

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    Language:Japanese Book type:Textbook, survey, introduction

  5. グリコサミノグリカンと疾病

    尾﨑 智也,坂元 一真,内村 健治,門松 健治( Role: Joint author)

    日本生化学会  2017 

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    Language:Japanese Book type:Textbook, survey, introduction

  6. 実験医学増刊 第三の生命鎖 糖鎖の機能と疾患 「硫酸化糖鎖と神経回路再編」

    坂元一真, 内村健治, 門松健治( Role: Joint author)

    羊土社  2013.6 

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    Language:Japanese

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Presentations 4

  1. Chondroitin sulfate and heparan sulfate determine axonal regeneration and its inhibition through PTPRσ-Cortactin-Autophagy axis International conference

    Sakamoto K, Kadomatsu K.

    HUPO 2019  2019.10  Human Proteome Organization

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    Event date: 2019.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Australia  

  2. Glycans and dystrophic endball Invited International conference

    Kazuma Sakamoto

    Glyco-Neuroscience Workshop  2019.5  Acdemia Sinica

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    Event date: 2019.5

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Taiwan  

  3. Dystrophic endball形成および軸索再生阻害における硫酸化糖鎖の役割 Invited

    坂元一真、門松健治

    第86回日本生化学会大会  2014 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:横浜みなとみらい   Country:Japan  

  4. Dystrophic endball形成の細胞生物学的基盤 Invited

    坂元一真 門松健治

    第123回日本解剖学会総会・全国学術集会  2018 

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    Language:Japanese   Presentation type:Oral presentation (invited, special)  

Research Project for Joint Research, Competitive Funding, etc. 8

  1. 愛知健康増進財団研究助成

    2021

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    Authorship:Principal investigator  Grant type:Other

    Grant amount:\500000

  2. 堀科学芸術振興財団研究助成

    2020

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    Authorship:Principal investigator  Grant type:Other

    Grant amount:\1000000

  3. 日東学術振興財団研究助成金

    2019

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    Authorship:Principal investigator  Grant type:Other

    Grant amount:\1000000

  4. 豊秋奨学会研究助成

    2019

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    Authorship:Principal investigator 

    Grant amount:\1500000

  5. テルモ生命科学振興財団研究開発助成

    2019

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    Authorship:Principal investigator  Grant type:Other

    Grant amount:\2000000

  6. 木下基礎科学研究基金

    2019

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    Authorship:Principal investigator  Grant type:Other

    Grant amount:\1000000

  7. 一般財団法人共済団医学研究奨励助成

    2016.4 - 2017.3

    学内共同研究 

  8. 公益財団法人堀科学芸術振興財団研究助成 

    2014.4 - 2015.3

    学内共同研究 

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KAKENHI (Grants-in-Aid for Scientific Research) 8

  1. 糖鎖ガイダンス分子が制御する神経マイクロサーキットの解明

    Grant number:23K05987  2023.4 - 2026.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    坂元 一真

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

  2. A new ligand for ALK and its activation mechanism

    Grant number:19H03415  2019.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  3. Establishment of substrates for receptor tyrosine phosphatase and its application

    Grant number:19K07348  2019.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    SAKAMOTO Kazuma

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    In this study, I aimed to establish a method for the comprehensive identification of substrates of receptor-type tyrosine phosphatases (RPTPs). In particular, we focused on PTPσ, a member of the RPTP family that is involved in the inhibition of axon regeneration in the central nervous systems. I applied a proximity-dependent ligation assay to identify the interacting molecules for PTPσ. As a result, approximately 100 proteins were identified as PTPσ interactors. This list included already-known interactors such as Liprin-α and Trio. Among these molecules, those involved in axon elongation were validated for their tyrosine phosphorylation and dephosphorylation by PTPσ. Together, a proximity-dependent ligation assay seems to be a powerful tool for the comprehensive identification of substrates for RPTP.

  4. The intracellular signaling of Midkine in neuroblastoma

    Grant number:16K08617  2016.4 - 2019.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Kishida Satoshi

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Midkine, a secreted growth factor, was shown to be involved in cisplatin resistance of bone marrow-metastasized neuroblastoma cells. The midkine-targetting therapy together with cisplatin could efficiently kill bone marrow-metastasized neuroblastma cells. We also found that mouse embryonic fibroblast (MEF) remarkably responded to midkine. This result suggests that midkine would signal not only to neuroblastoma cells but also stromal cells including fibroblasts.

  5. Identification down stream factors of tyrosine phosphatase which negatively regulate autophagy flux and axonal regeneration

    Grant number:16K19049  2016.4 - 2018.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    Sakamoto Kazuma

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    Upon injury, the distal terminal of axon transforms into so-called dystrophic endball. This degenerative structure has been thought to be closely associated with inability of regeneration of our axons in the cetral nervous system. However, underlying molecular mechanism except neuronal cell-surface molecule, PTPRσ, has been unknown. Here I have identified Cortactin as a new substrate for PTPRσ. Cortactin was de-phosphorylated by PTPRσ, and its phosphorylated form was completely diminished in dystrophic endball. Furthermore, knock-down of Cortactin in cultured neurons led to inhibition of axonal elongation, and swollen structures with autophagosomal accumulation which was specific character of dystrophic endball.
    Taken together, these results have revealed a pivotal role of PTPRσ-Cortactin axis in axonal regeneration and its inhibition.

  6. Neuronal cell surface mechanisms which induce dystrophic endball

    Grant number:26860209  2014.4 - 2016.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    Sakamoto Kazuma

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    Authorship:Principal investigator 

    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    Heparan sulfate and chondroitin sulfate are sulfated glycans which are involved in axonal elongation in our central nervous system. Although they share the same neuronal receptor PTPσ, how they differentially regulate it is still unknown. Here, minimum essential structures of heparan sulfate and chondroitin sulfate were successfully identified. In both glycans, tetrasaccharide is the shortest structure to interact with PTPσ. However, interestingly, the probability of the structures is quite rare in chondroitin sulfate, while quite rich in heparan sulfate. These findings account for how heparan sulfate and chondroitin sulfate work in opposing manner on PTPσ and axonal elongation.

  7. Identification of receptors for phosphacan which inhibit axonal regeneration

    Grant number:24890084  2012.8 - 2014.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Research Activity Start-up

    SAKAMOTO Kazuma

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    Authorship:Principal investigator 

    Grant amount:\2600000 ( Direct Cost: \2000000 、 Indirect Cost:\600000 )

    Highly purified recombinant phosphacan was purepared using anion exchange and gel filtration chromatography. Increasing gradient of recombinant phosphacan induced dystrophic endball, a morphological marker for regeneration stopping axons, to cultured dorsal root ganglion neurons. Using electron microscope and immunocytochemistry, autophagosomes were found in dystrophic endball, suggesting that autophagy is an essential cellular event for formation of dystrophic endball.
    Surface plasmon resonance assay revealed that phosphacan strongly bound to PTPsigma and LAR which are known as receptors for chondroitin sulfate. Surprisingly, interaction between phosphacan and PTPsigma or LAR was two-phase manner, and not only chondroitin sulfate but also keratan sulfate were involved in interaction. Free keratan sulfate sugar also bound to PTPsigma and LAR.
    PTPzeta, another member of receptors tyrosine phosphatase, was also identified to be involved in inhibition of axonal regeneration.

  8. オートクラインループにおける小胞体シャペロンの意義

    2008.4 - 2011.3

    科学研究費補助金 

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    Authorship:Principal investigator  Grant type:Competitive

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Industrial property rights 1

  1. OCTASHHACHARIDES AND THEIR USES OF

    HUNG Shang-Cheng, Kenji Kadomatsu, Kazuma Sakamoto, KO Yen-Chun, TSAI Cheng-Fang, FAN Chiao-Yuan

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    Applicant:HUNG Shang-Cheng, Kenji Kadomatsu, Kazuma Sakamoto, KO Yen-Chun, TSAI Cheng-Fang, FAN Chiao-Yuan

    Application no:PCT/US2018/06057  Date applied:2018.12

    Announcement no:WO2019/118525 A1  Date announced:2019.6

 

Teaching Experience (On-campus) 31

  1. 生物の化学  講義

    2023

  2. 生物の化学 実習

    2023

  3. 基礎医学セミナー

    2023

  4. 生物学基礎

    2023

  5. 人体機能学

    2023

  6. 人体機能学

    2022

  7. 生物学基礎

    2022

  8. 生物の化学  講義

    2022

  9. 生物の化学 実習

    2022

  10. 基礎医学セミナー

    2022

  11. 基礎医学セミナー

    2021

  12. 生物の化学 実習

    2021

  13. 生物学基礎

    2021

  14. 生物の化学 講義

    2021

  15. 基礎医学セミナー

    2020

  16. 生物学基礎

    2020

  17. 生物の化学 実習

    2020

  18. 生物の化学 講義

    2020

  19. 生物の化学 講義

    2019

  20. 生物学基礎

    2019

  21. 基礎医学セミナー

    2019

  22. 生物の化学 実習

    2019

  23. 生物の化学 講義

    2018

  24. 基礎医学セミナー

    2018

  25. 生物の化学 実習

    2018

  26. 基礎医学セミナー

    2017

  27. 生物の化学 実習

    2017

  28. 生物の化学

    2017

  29. 基礎医学セミナー

    2016

  30. 生物の化学 実習

    2016

  31. 生物の化学

    2016

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Media Coverage 2

  1. プレスリリース 台湾 Internet

    2019.5

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    Author:Myself 

  2. プレスリリース Newspaper, magazine

    2019.5

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    Author:Myself 

Academic Activities 3

  1. 第95回日本生化学会大会 幹事補佐

    Role(s):Planning, management, etc.

    日本生化学会  2021.3 - 2022.12

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    Type:Competition, symposium, etc. 

  2. 日本生化学会中部支部幹事

    Role(s):Planning, management, etc.

    日本生化学会  2018.9 - 2020.8

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    Type:Academic society, research group, etc. 

  3. J Biochemistry誌 Editorial Assistant International contribution

    Role(s):Review, evaluation, Peer review

    日本生化学会  2018 - 2021

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    Type:Scientific advice/Review