Updated on 2026/03/12

写真a

 
MAKITA Satoshi
 
Organization
Nagoya University Hospital Children's Cancer Center Lecturer of hospital
Title
Lecturer of hospital

Degree 1

  1. 医学（博士） （ 2018.3   名古屋大学 ） 

To the head of Degree.▲

Research Interests 1

  1. Pediatric surgery

To the head of Research Interests.▲

Research Areas 1

  1. Life Science / General surgery, pediatric surgery

To the head of Research Areas.▲
 

Papers 137

  1. Effect of General Anesthesia on Liver and Spleen Stiffness for Predicting High-Risk Varices in Biliary Atresia Reviewed

    Yokoyama, S; Honda, T; Ishizu, Y; Imai, N; Ito, T; Yamamoto, K; Shirota, C; Tainaka, T; Makita, S; Nakamura, M; Uchida, H; Kawashima, H

    HEPATOLOGY RESEARCH   Vol. 56 ( 2 ) page： 223 - 232   2026.2

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  2. The First Case of Bile Duct Resection Using the da Vinci SP for Congenital Biliary Dilatation in an Infant Reviewed

    Makita, S; Uchida, H; Hinoki, A; Shirota, C; Tainaka, T; Amano, H; Ogawa, K; Okamoto, M; Takimoto, A; Yasui, A; Takada, S; Hayashi, K; Nakagawa, Y; Kato, D; Ishii, H; Asai, H; Ota, K; Murata, Y; Liu, JH; Guo, YH

    ASIAN JOURNAL OF ENDOSCOPIC SURGERY   Vol. 19 ( 1 ) page： e70246   2026.1

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    Language：English   Publisher：Asian Journal of Endoscopic Surgery  

    We report the first infant case of congenital biliary dilatation (CBD) treated using the da Vinci SP system. A 4-month-old boy (7.9 kg) with Todani type IV-A CBD underwent complete extrahepatic bile duct excision, hilar bile duct plasty, and hepaticojejunostomy through a 2.7-cm umbilical incision with an additional 3-mm assistant port. Operative time was 343 min with minimal blood loss. Recovery was uneventful, and the patient was discharged on postoperative day 7. This case demonstrates the feasibility of SP-assisted minimally invasive surgery in small infants.

    DOI： 10.1111/ases.70246

    Web of Science

    Scopus

    PubMed

  3. Hyponatremia after pediatric surgery: Randomized trial of fluid composition on antidiuretic hormone response Reviewed

    Yokota, K; Uchida, H; Manaka, K; Nangaku, M; Kuwatsuka, Y; Ando, M; Nishiwaki, K; Hirai, T; Tainaka, T; Shirota, C; Sumida, W; Makita, S; Amano, H; Hinoki, A

    PEDIATRIC RESEARCH   Vol. 99 ( 1 ) page： 263 - 269   2026.1

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  4. Strategy of reduced port gastrostomy as a safe procedure for paediatric patients Reviewed

    Gohda, Y; Uchida, H; Tainaka, T; Sumida, W; Shirota, C; Makita, S; Satomi, M; Yasui, A; Kato, D; Maeda, T; Ishii, H; Ota, K; Guo, YH; Liu, JH; Hinoki, A

    JOURNAL OF MINIMAL ACCESS SURGERY   Vol. 22 ( 1 ) page： 22 - 26   2026.1

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  5. One-stage minimally invasive surgery is as safe and feasible as two-stage surgery for perforated choledochal cyst in pediatric patients who are hemodynamically stable Reviewed

    Tainaka, T; Shirota, C; Makita, S; Amano, H; Kano, Y; Yasui, A; Nakagawa, Y; Kato, D; Maeda, T; Ishii, H; Murata, Y; Utsunomiya, A; Hinoki, A; Uchida, H

    SURGERY TODAY     2025.12

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  6. Comparison of Postoperative Outcomes of Open, Laparoscopic, and Robotic Surgery for Pediatric Choledochal Cyst Excision Reviewed

    Maeda, T; Uchida, H; Shirota, C; Tainaka, T; Makita, S; Yasui, A; Kato, D; Ishii, H; Asai, H; Utsunomiya, A

    JOURNAL OF PEDIATRIC SURGERY   Vol. 60 ( 12 ) page： 162642   2025.12

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  7. Long-Term Outcomes of Congenital Biliary Dilatation Surgery: A Single-Center Study Highlighting the High Incidence of Complications Within 5 Years Reviewed

    Maeda, T; Uchida, H; Shirota, C; Tainaka, T; Makita, S; Asai, H; Utsunomiya, A; Murata, Y; Guo, YH; Liu, JH

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 32 ( 12 ) page： 901 - 909   2025.12

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  8. 特集 総排泄腔遺残症 小腸グラフトを使用した内視鏡的腟形成術 Reviewed

    加藤 大幾, 内田 広夫, 城田 千代栄, 田井中 貴久, 牧田 智, 小川 雄大, 岡本 眞宗, 滝本 愛太朗, 安井 昭洋, 高田 瞬也, 林 海斗, 中川 洋一, 石井 宏樹, 浅井 一, 太田 和樹

    小児外科   Vol. 57 ( 11 ) page： 1192 - 1195   2025.11

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    Publisher：東京医学社  

    DOI： 10.24479/ps.0000001378

    CiNii Research

  9. Cystathionine as a Potential Urinary Marker for Diagnosing and Assessing Pretreatment Risk in Neuroblastoma Reviewed

    Amano, H; Hayashi, Y; Harada, K; Narita, A; Fumino, S; Yamada, Y; Karakawa, S; Sakairi, M; Shirota, C; Tainaka, T; Yokota, K; Makita, S; Kato, D; Ishii, H; Deie, K; Mori, M; Mitani, Y; Tomioka, Y; Taguri, M; Koh, K; Tajiri, T; Kato, M; Matsumoto, K; Takahashi, Y; Iehara, T; Hinoki, A; Uchida, H

    CANCER SCIENCE   Vol. 116 ( 11 ) page： 3102 - 3112   2025.11

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  10. Current status of neonatal surgery in Japan: An analysis of data from the National Clinical Database Pediatric Surgical Registry Reviewed

    Masahata, K; Tachimori, H; Ishimaru, T; Kawakubo, N; Usui, Y; Koike, Y; Jimbo, T; Nose, S; Makita, S; Honda, S; Nakata, M; Yoneda, A; Ono, S

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 41 ( 1 ) page： 323   2025.10

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  11. Preoperative classification based on intrahepatic bile duct morphology for predicting postoperative complications in congenital biliary dilatation Reviewed

    Kato, D; Uchida, H; Shirota, C; Tainaka, T; Makita, S; Yasui, A; Nakagawa, Y; Maeda, T; Ishii, H; Amano, H; Hinoki, A

    SURGERY   Vol. 186   page： 109596   2025.10

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  12. Safety and efficacy of robot-assisted bile ductoplasty and intrapancreatic bile duct resection in congenital biliary dilatation: a single-center retrospective cohort (2013-2024) Reviewed

    Kato, D; Shirota, C; Uchida, H; Hinoki, A; Makita, S; Ogawa, K; Okamoto, M; Yasui, A; Takada, S; Hayashi, K; Nakagawa, Y; Ishii, H; Asai, H; Amano, H; Tainaka, T

    JOURNAL OF ROBOTIC SURGERY   Vol. 19 ( 1 ) page： 618   2025.9

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  13. First Report of Single-Surgeon Single-Incision Laparoscopic Percutaneous Extraperitoneal Closure Using the Senhance Robotic System as Camera Holder for Pediatric Inguinal Hernia Reviewed

    Kato, D; Tainaka, T; Shirota, C; Makita, S; Ogawa, K; Okamoto, M; Yasui, A; Takada, S; Hayashi, K; Nakagawa, Y; Ishii, H; Asai, H; Utsunomiya, A; Hinoki, A; Nagata, N; Uchida, H

    ASIAN JOURNAL OF ENDOSCOPIC SURGERY   Vol. 18 ( 1 ) page： e70131   2025.8

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  14. Thoracoscopic Posterior Tracheopexy After Esophageal Atresia Repair: A Case Report Reviewed

    Makita, S; Uchida, H; Hinoki, A; Shirota, C; Tainaka, T; Amano, H; Yasui, A; Nakagawa, Y; Kato, D; Maeda, T; Ishii, H; Asai, H; Murata, Y; Utsunomiya, A; Liu, JH; Guo, YH

    ASIAN JOURNAL OF ENDOSCOPIC SURGERY   Vol. 18 ( 1 ) page： e70128   2025.8

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  15. Emergency One-Stage Robotic Surgery for Congenital Biliary Dilatation With Bile Duct Perforation in a Pediatric Patient: A Case Report Reviewed

    Asai, H; Shirota, C; Tainaka, T; Makita, S; Ogawa, K; Okamoto, M; Yasui, A; Takada, S; Hayashi, K; Nakagawa, Y; Katou, D; Ishii, H; Utsunomiya, A; Uchida, H

    ASIAN JOURNAL OF ENDOSCOPIC SURGERY   Vol. 18 ( 1 ) page： e70122   2025.7

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  16. A Case of Neonatal Milk Allergy With Hematemesis, Shock, and Hepatic Portal Venous Gasemia Reviewed Open Access

    Ogata Seiya, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Takada Shunya, Nakagawa Yoichi, Gohda Yousuke, Hinoki Akinari, Uchida Hiroo

    Journal of the Japanese Society of Pediatric Surgeons   Vol. 61 ( 4 ) page： 723 - 727   2025.6

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    Language：Japanese   Publisher：The Japanese Society of Pediatric Surgeons  

    <p>We experienced treating a case of neonatal milk allergy presenting with haematemesis, shock, and hepatic portal venous gasemia. The patient was an 8-day-old male infant, born at 39 weeks and 4 days of gestation, weighing 3,020 g. He vomited on day 1 of life and passed a small amount of fresh blood in his stool on day 3. He was observed by a local physician but presented to his previous doctor on day 8 with poor feeding, somnolence, frequent vomiting, and red-brown watery stools. Haematemesis, portal vein gas on plain abdominal radiographs, and intestinal dilatation on contrast-enhanced CT raised suspicion of strangulated bowel obstruction, prompting his transfer to our hospital for emergency surgery. However, ultrasonography and contrast-enhanced CT revealed generalized thickening of the intestinal wall without signs of obstruction or necrosis. On the basis of these findings, milk allergy was suspected, and conservative treatment was initiated. The patient’s symptoms rapidly improved, and allergen-specific lymphocyte stimulation tests showed strong positivity for κ-casein, β-casein, and lactoferrin, confirming the diagnosis of milk allergy. This case highlights the importance of thoroughly evaluating abdominal findings and imaging studies to establish a differential diagnosis, including milk allergy, even in the presence of shock and hepatic portal venous gasemia.</p>

    DOI： 10.11164/jjsps.61.4_723

    Open Access

    CiNii Research

  17. Hyponatremia is not induced by postoperative hypotonic fluids in infants with biliary atresia after sufficient diuresis Reviewed

    Yokota, K; Uchida, H; Shirota, C; Tainaka, T; Sumida, W; Makita, S; Amano, H; Nakagawa, Y; Maeda, T; Gohda, Y; Kato, D; Hinoki, A

    PEDIATRICS INTERNATIONAL   Vol. 67 ( 1 ) page： e70016   2025.5

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  18. Young pediatric surgeons without endoscopic surgical skill qualification safely perform advanced endoscopic surgery under the supervision of expert qualified surgeons Reviewed

    Ota, K; Tainaka, T; Hinoki, A; Shirota, C; Makita, S; Yasui, A; Nakagawa, Y; Kato, D; Maeda, T; Ishii, H; Uchida, H

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   Vol. 39 ( 5 ) page： 2925 - 2930   2025.5

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  19. Learning curve comparison of robot-assisted and laparoscopic hepaticojejunostomy: a focus on critical suturing Reviewed

    Liu, JH; Maeda, T; Shirota, C; Tainaka, T; Sumida, W; Makita, S; Gohda, Y; Nakagawa, Y; Takimoto, A; Guo, YH; Kato, D; Yasui, A; Hinoki, A; Uchida, H

    FRONTIERS IN PEDIATRICS   Vol. 13   page： 1558362   2025.3

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  20. Developing an Effective Off-the-job Training Model and an Automated Evaluation System for Thoracoscopic Esophageal Atresia Surgery Reviewed

    Yasui, A; Hayashi, Y; Hinoki, A; Amano, H; Shirota, C; Tainaka, T; Sumida, W; Makita, S; Kano, Y; Takimoto, A; Nakagawa, Y; Takuya, M; Kato, D; Gohda, Y; Liu, JH; Guo, YH; Mori, K; Uchida, H

    JOURNAL OF PEDIATRIC SURGERY   Vol. 60 ( 2 ) page： 161615   2025.2

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  21. Evaluation of the risk factors for postoperative pectus excavatum and scoliosis in cystic lung disease. Reviewed

    Takahisa T, Chiyoe S, Wataru S, Satoshi M, Hizuru A, Yoko K, Akihiro Y, Daiki K, Takuya M, Yousuke G, Hiroki I, Kazuki O, Akinari H, Hiroo U

    Pediatric surgery international   Vol. 41 ( 1 ) page： 62   2025.1

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    Language：English  

    DOI： 10.1007/s00383-024-05925-4

    PubMed

  22. Emergency Surgical Management of Chemotherapy-Induced Tumor Rupture in a Patient with MYCN-Amplified Neuroblastoma: A Case Report

    Ogawa Katsuhiro, Makita Satoshi, Utsunomiya Ami, Asai Hajime, Ishii Hiroki, Kato Daiki, Nakagawa Yoichi, Hayashi Kaito, Takada Shunya, Takimoto Aitaro, Yasui Akihiro, Okamoto Masamune, Tainaka Takahisa, Shirota Chiyoe, Uchida Hiroo

    Surgical Case Reports   Vol. 11 ( 1 ) page： n/a   2025

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    Language：English   Publisher：Japan Surgical Society  

    <p><b>INTRODUCTION:</b> Tumor rupture with neuroblastoma is an uncommon but serious complication, particularly in high-risk cases involving MYCN amplification. When rupture occurs soon after induction chemotherapy is initiated, rapid deterioration and abdominal compartment syndrome (ACS) may develop. Early identification of high-risk patients and their readiness for surgical management are essential to optimizing outcomes.</p><p><b>CASE PRESENTATION:</b> A 4-year-old girl presented with a large left adrenal mass and elevated neuroblastoma markers. Imaging showed a heterogeneous 11 × 9.5 × 17-cm tumor encasing the renal hilum. Because of intratumoral hemorrhage, biopsy was deferred and induction chemotherapy was initiated. Seven days later, sudden abdominal distension and severe anemia developed. Contrast-enhanced CT confirmed intraperitoneal bleeding from the ruptured tumor. Transarterial embolization, including occlusion of the left renal artery, achieved temporary hemostasis; however, intra-abdominal pressure increased to 20 mmHg, thus meeting the ACS criteria. Emergency laparotomy revealed extensive hemorrhagic ascites and a ruptured tumor capsule. En bloc resection of the tumor and left nephrectomy were performed over 4 hours, and total blood loss of 2968 mL occurred. Histopathology confirmed MYCN-amplified neuroblastoma invading the adjacent renal parenchyma, which was classified as high risk by the International Neuroblastoma Risk Group. Postoperatively, the chylous ascites resolved by day 11, and multimodal therapy, including chemotherapy, autologous stem cell transplantation, proton beam radiotherapy, and anti-GD2 antibody therapy, was completed. Remission has been maintained for 2 years.</p><p><b>CONCLUSIONS:</b> Embolization alone may not prevent ACS in patients with MYCN-amplified neuroblastoma and chemotherapy-induced rupture. Prompt surgical resection can be life-saving when anatomically feasible. A pretreatment risk assessment, cautious initiation of chemotherapy, vigilant monitoring, and early surgical preparedness are critical for managing high-risk neuroblastoma.</p>

    DOI： 10.70352/scrj.cr.25-0473

    Open Access

    Web of Science

    PubMed

    CiNii Research

  23. 当科で経験した先天性胆道拡張症術後肝内結石に対する肝切除の4例 Reviewed Open Access

    牧田 智, 内田 広夫, 檜 顕成, 城田 千代栄, 田井中 貴久, 天野 日出, 小川 雄大, 岡本 慎宗, 安井 昭洋, 高田 瞬也, 林 海斗, 中川 洋一, 加藤 大幾, 石井 宏樹, 浅井 一, 宇都宮 有美, 村田 結衣, Yaohui Guo, Liu Jiahui

    日本膵・胆管合流異常研究会プロシーディングス   Vol. 48 ( 0 ) page： 80 - 81   2025

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    Language：Japanese   Publisher：日本膵・胆管合流異常研究会  

    DOI： 10.34410/jspbm.48.0_80

    Open Access

    CiNii Research

  24. 子どもvs大人：ロボット支援先天性胆道拡張症手術の成績と術中課題 Reviewed Open Access

    林 海斗, 内田 広夫, 城田 千代栄, 田井中 貴久, 牧田 智, 小川 雄大, 安井 昭洋, 岡本 慎宗, 高田 瞬也, 中川 洋一, 加藤 大幾, 石井 宏樹, 浅井 一, 太田 和樹

    日本膵・胆管合流異常研究会プロシーディングス   Vol. 48 ( 0 ) page： 38 - 39   2025

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    Language：Japanese   Publisher：日本膵・胆管合流異常研究会  

    DOI： 10.34410/jspbm.48.0_38

    Open Access

    CiNii Research

  25. 先天性胆道拡張症の術前肝内胆管形態による長期合併症予測 Reviewed Open Access

    加藤 大幾, 内田 広夫, 城田 千代栄, 田井中 貴久, 牧田 智, 小川 雄大, 岡本 眞宗, 安井 昭洋, 高田 瞬也, 林 海斗, 中川 洋一, 石井 宏樹, 浅井 一, 宇都宮 有美

    日本膵・胆管合流異常研究会プロシーディングス   Vol. 48 ( 0 ) page： 78 - 79   2025

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    Language：Japanese   Publisher：日本膵・胆管合流異常研究会  

    DOI： 10.34410/jspbm.48.0_78

    Open Access

    CiNii Research

  26. Safety and feasibility of robot-assisted surgery for pediatric patients weighing ≤ 10 kg with congenital biliary dilatation Reviewed

    Ishii, H; Shirota, C; Tainaka, T; Makita, S; Satomi, M; Kato, D; Maeda, T; Ota, K; Hinoki, A; Uchida, H

    JOURNAL OF ROBOTIC SURGERY   Vol. 19 ( 1 ) page： 34   2024.12

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  27. Characteristics and outcomes of minimally invasive surgery for congenital biliary dilatation in children aged <6 years: Comparison between children and adults Reviewed

    Nakagawa, Y; Uchida, H; Shirota, C; Tainaka, T; Makita, S; Satomi, M; Yasui, A; Kano, Y; Kato, D; Maeda, T

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 31 ( 12 ) page： 876 - 885   2024.12

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  28. Usefulness of lateral-anteroposterior dimeter ratio in patients with tracheomalacia associated with esophageal atresia Reviewed

    Sumida, W; Tainaka, T; Shirota, C; Makita, S; Amano, H; Yasui, A; Maeda, T; Kato, D; Goda, Y; Ishii, H; Ota, K; Yaohui, G; Jiahui, L; Hinoki, A; Uchida, H

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 40 ( 1 ) page： 282   2024.10

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  29. Nationwide questionnaire survey on pediatric pancreatic tumors in Japan Reviewed

    Makita, S; Uchida, H; Kano, M; Kawakubo, N; Miyake, H; Yoneda, A; Tajiri, T; Fukumoto, K

    WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY   Vol. 16 ( 10 ) page： 4166 - 4176   2024.10

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  30. 特集 必携小児外科レジデントマニュアル2 手術器具 Reviewed

    田井中 貴久, 城田 千代栄, 牧田 智, 天野 日出, 檜 顕成, 内田 広夫

    小児外科   Vol. 56 ( 9 ) page： 933 - 937   2024.9

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    Publisher：東京医学社  

    DOI： 10.24479/ps.0000000944

    CiNii Research

  31. First pediatric pelvic surgery with the Senhance® robotic surgical system: A case series Reviewed

    Kato, D; Uchida, H; Shirota, C; Tainaka, T; Makita, S; Amano, H; Satomi, M; Yasui, A; Nakagawa, Y; Maeda, T; Ishii, H; Ota, K; Nagata, N; Hinoki, A

    ASIAN JOURNAL OF ENDOSCOPIC SURGERY   Vol. 17 ( 4 ) page： e13379   2024.8

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  32. Eicosapentaenoic acid administration ameliorates the progression of liver fibrosis after laparoscopic Kasai portoenterostomy Reviewed

    Sumida, W; Tainaka, T; Shirota, C; Makita, S; Amano, H; Yasui, A; Maeda, T; Kato, D; Goda, Y; Ishii, H; Ota, K; Guo, YH; Liu, JH; Hinoki, A; Uchida, H

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 40 ( 1 ) page： 239   2024.8

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  33. 特集 再手術の戦略と実際 胆道閉鎖症 Reviewed

    城田 千代栄, 田井中 貴久, 牧田 智, 加藤 大幾, 前田 拓也, 里見 美和, 石井 宏樹, 太田 和樹, 檜 顕成, 内田 広夫

    小児外科   Vol. 56 ( 7 ) page： 701 - 703   2024.7

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    Publisher：東京医学社  

    DOI： 10.24479/ps.0000000881

    CiNii Research

  34. 特集 再手術の戦略と実際 先天性横隔膜ヘルニア再発に対する手術アプローチ Reviewed

    合田 陽祐, 内田 広夫, 横田 一樹, 城田 千代栄, 田井中 貴久, 住田 亙, 牧田 智, 里見 美和, 安井 昭洋, 加藤 大幾, 前田 拓也, 石井 宏樹, 太田 和樹, 檜 顕成

    小児外科   Vol. 56 ( 7 ) page： 682 - 685   2024.7

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    Publisher：東京医学社  

    DOI： 10.24479/ps.0000000877

    CiNii Research

  35. Bile lakes in patients with biliary atresia who presented with jaundice-free native liver survival indicating the risk of subsequent liver transplantation due to various factors Reviewed

    Gohda, Y; Uchida, H; Sumida, W; Shirota, C; Tainaka, T; Makita, S; Satomi, M; Yasui, A; Kato, D; Maeda, T; Ishii, H; Ota, K; Guo, YH; Liu, JH; Hinoki, A

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 40 ( 1 ) page： 197   2024.7

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  36. Thoracoscopic primary repair is useful for esophageal atresia with tracheoesophageal fistula in neonates with low body weight Reviewed

    Gohda, Y; Uchida, H; Shirota, C; Tainaka, T; Sumida, W; Makita, S; Satomi, M; Yasui, A; Kanou, Y; Nakagawa, Y; Kato, D; Maeda, T; Guo, YH; Liu, JH; Ishii, H; Ota, K; Hinoki, A

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 40 ( 1 ) page： 149   2024.6

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  37. Safe thoracoscopic repair of recurrent congenital diaphragmatic hernia after initial open abdominal repair Reviewed Open Access

    Gohda, Y; Yokota, K; Uchida, H; Shirota, C; Tainaka, T; Sumida, W; Makita, S; Takimoto, A; Takada, S; Nakagawa, Y; Maeda, T; Guo, YH; Hinoki, A

    SURGERY TODAY   Vol. 54 ( 6 ) page： 534 - 539   2024.6

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  38. Scoring system for diagnosis and pretreatment risk assessment of neuroblastoma using urinary biomarker combinations Reviewed

    Amano, H; Uchida, H; Harada, K; Narita, A; Fumino, S; Yamada, Y; Kumano, S; Abe, M; Ishigaki, T; Sakairi, M; Shirota, C; Tainaka, T; Sumida, W; Yokota, K; Makita, S; Karakawa, S; Mitani, Y; Matsumoto, S; Tomioka, Y; Muramatsu, H; Nishio, N; Osawa, T; Taguri, M; Koh, K; Tajiri, T; Kato, M; Matsumoto, K; Takahashi, Y; Hinoki, A

    CANCER SCIENCE   Vol. 115 ( 5 ) page： 1634 - 1645   2024.5

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  39. A new criterion including the aspartate aminotransferase-to-platelet ratio index and liver and spleen stiffness to rule out varices needing treatment in children with biliary atresia: Modification of the Baveno VII criteria Reviewed Open Access

    Yokoyama, S; Ishizu, Y; Honda, T; Imai, N; Ito, T; Yamamoto, K; Muto, H; Shirota, C; Tainaka, T; Sumida, W; Makita, S; Takada, S; Nakagawa, Y; Maeda, T; Nakamura, M; Ishigami, M; Uchida, H; Kawashima, H

    HEPATOLOGY RESEARCH   Vol. 54 ( 4 ) page： 347 - 357   2024.4

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  40. Duodenal duplication cyst at the second part of the duodenum with congenital duodenal position anomaly completely resected by laparoscopic partial duodenectomy: a case report Reviewed

    Nakagawa, Y; Uchida, H; Makita, S; Tainaka, T; Hinoki, A; Shirota, C; Sumida, W; Amano, H; Yasui, A; Kano, Y; Maeda, T; Kato, D; Gohda, Y

    SURGICAL CASE REPORTS   Vol. 10 ( 1 ) page： 73   2024.3

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  41. A systematic review of Sandifer syndrome in children with severe gastroesophageal reflux Reviewed

    Kato, D; Uchida, H; Amano, H; Yokota, K; Shirota, C; Tainaka, T; Sumida, W; Makita, S; Yasui, A; Gohda, Y; Maeda, T; Hinoki, A

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 40 ( 1 ) page： 91   2024.3

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  42. Laparoscopic Fundoplication in Patients with Ventriculoperitoneal Shunts: A Systematic Review and Our Experience Reviewed Open Access

    Kato, D; Uchida, H; Tainaka, T; Amano, H; Ono, Y; Yasui, A; Shirota, C; Sumida, W; Yokota, K; Makita, S; Takimoto, A; Takada, S; Nakagawa, Y; Gohda, Y; Maeda, T; Hinoki, A

    JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES   Vol. 34 ( 3 ) page： 268 - 273   2024.3

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  43. Surgical Strategies for Neonates with Prenatally Diagnosed Congenital Biliary Dilatation Reviewed

    Shirota, C; Hinoki, A; Tainaka, T; Sumida, W; Makita, S; Amano, H; Takimoto, A; Yasui, A; Nakagawa, Y; Liu, JH; Guo, YH; Kato, D; Goda, Y; Maeda, T; Uchida, H

    JOURNAL OF PEDIATRIC SURGERY   Vol. 59 ( 3 ) page： 385 - 388   2024.3

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  44. Update on aortopexy and posterior tracheopexy for tracheomalacia in patients with esophageal atresia Reviewed

    Sumida, W; Yasui, A; Shirota, C; Makita, S; Okamoto, M; Ogata, S; Takimoto, A; Takada, S; Nakagawa, Y; Kato, D; Gohda, Y; Amano, H; Guo, YH; Hinoki, A; Uchida, H

    SURGERY TODAY   Vol. 54 ( 3 ) page： 211 - 219   2024.3

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  45. 食道閉鎖症に対する治療戦略：私達はなぜ胸腔鏡手術を選択するのか Reviewed Open Access

    内田 広夫, 田井中 貴久, 城田 千代栄, 住田 亙, 牧田 智, 横田 一樹, 安井 昭洋, 高田 瞬也, 中川 洋一, 前田 拓也, 加藤 大幾, 合田 陽祐, 郭 垚輝, 劉 佳慧

    日本周産期・新生児医学会雑誌   Vol. 59 ( 4 ) page： 470 - 474   2024

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    Language：Japanese   Publisher：一般社団法人 日本周産期・新生児医学会  

    <p>　はじめに</p><p>　名古屋大学小児外科では，食道閉鎖症に対して胸腔鏡下根治術を第一選択としている．アメリカでの現状，meta-analysisに触れながら，当院の治療戦略について簡単に述べる．</p>

    DOI： 10.34456/jjspnm.59.4_470

    Open Access

    CiNii Research

  46. 当院におけるロボット支援腹腔鏡下胆道拡張症手術について Reviewed Open Access

    田井中 貴久, 城田 千代栄, 牧田 智, 里見 美和, 狩野 陽子, 安井 昭和, 中川 洋一, 加藤 大幾, 前田 拓也, 石井 宏樹, 太田 和樹, 天野 日出, 檜 顕成, 内田 広夫

    日本膵・胆管合流異常研究会プロシーディングス   Vol. 47 ( 0 ) page： 62 - 63   2024

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    Language：Japanese   Publisher：日本膵・胆管合流異常研究会  

    DOI： 10.34410/jspbm.47.0_62

    Open Access

    CiNii Research

  47. 10kg 未満の患者に対してもロボット支援腹腔鏡下先天性胆道拡張症手術は安全に行える Reviewed Open Access

    石井 宏樹, 内田 広夫, 城田 千代栄, 田井中 貴久, 牧田 智, 里見 美和, 安井 昭洋, 中川 洋一, 加藤 大幾, 前田 拓也, 太田 和樹

    日本膵・胆管合流異常研究会プロシーディングス   Vol. 47 ( 0 ) page： 66 - 66   2024

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    Language：Japanese   Publisher：日本膵・胆管合流異常研究会  

    DOI： 10.34410/jspbm.47.0_66

    Open Access

    CiNii Research

  48. Anastomotic time was associated with postoperative complications: a cumulative sum analysis of thoracoscopic repair of tracheoesophageal fistula in a single surgeon's experience Reviewed

    Guo, YH; Hinoki, A; Deie, K; Tainaka, T; Sumida, W; Makita, S; Okamoto, M; Takimoto, A; Yasui, A; Takada, S; Nakagawa, Y; Kato, D; Maeda, T; Amano, H; Kawashima, H; Uchida, H; Shirota, C

    SURGERY TODAY   Vol. 53 ( 12 ) page： 1363 - 1371   2023.12

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  49. Application of indocyanine green fluorescence imaging navigation in pediatric surgery: A single-center review Reviewed Open Access

    Shirota, C; Hinoki, A; Tainaka, T; Sumida, W; Makita, S; Amano, H; Takimoto, A; Yasui, A; Takada, S; Nakagawa, Y; Uchida, H

    JOURNAL OF PEDIATRIC SURGERY OPEN   Vol. 4   2023.12

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  50. Preoperative management comprising tube irrigation using a trans-anal indwelling tube for infants with hirschsprung disease can allow single-stage radical surgery Reviewed Open Access

    Nakagawa, Y; Uchida, H; Hinoki, A; Tainaka, T; Shirota, C; Sumida, W; Makita, S; Yokota, K; Amano, H; Yasui, A; Maeda, T; Kato, D; Gohda, Y

    BMC SURGERY   Vol. 23 ( 1 ) page： 333   2023.11

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  51. Variations of the hepatic artery and bile duct in patients with pancreaticobiliary maljunction: Impact on postoperative outcomes Reviewed Open Access

    Takada, S; Uchida, H; Hinoki, A; Shirota, C; Sumida, W; Tainaka, T; Makita, S; Takimoto, A; Nakagawa, Y; Maeda, T

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 30 ( 11 ) page： 1241 - 1248   2023.11

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  52. Refractory esophageal anastomotic stricture after esophageal atresia surgery improved with retrograde balloon dilatation through gastrostomy followed by laparoscopic fundoplication: a case report Reviewed Open Access

    Nakagawa, Y; Uchida, H; Hinoki, A; Shirota, C; Sumida, W; Makita, S; Yokota, K; Amano, H; Yasui, A; Kato, D; Gohda, Y; Maeda, T

    SURGICAL CASE REPORTS   Vol. 9 ( 1 ) page： 169   2023.9

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  53. Robotic versus laparoscopic radical surgery for pediatric congenital biliary dilatation: a comparison of surgical outcomes of a single surgeon's initial experience Reviewed Open Access

    Maeda, T; Liu, JH; Uchida, H; Amano, H; Shirota, C; Tainaka, T; Sumida, W; Makita, S; Takimoto, A; Takada, S; Nakagawa, Y; Gouda, A; Guo, YH; Hinoki, A

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 39 ( 1 ) page： 261   2023.9

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  54. Management of Congenital and Postoperative Chylothorax: Use of Thoracoscopic Lymphatic Leak Ligations with Intraoperative ICG Lymphangiography Reviewed Open Access

    Takada, S; Shirota, C; Uchida, H; Amano, H; Hinoki, A; Sumida, W; Makita, S; Okamoto, M; Takimoto, A; Yasui, A; Nakagawa, Y; Kato, D; Guo, YH; Tainaka, T

    JOURNAL OF PEDIATRIC SURGERY   Vol. 58 ( 9 ) page： 1754 - 1761   2023.9

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  55. 特集 急性虫垂炎:診断,治療,研究 複雑性虫垂炎の緊急手術 Reviewed

    田井中 貴久, 城田 千代栄, 住田 亙, 横田 一樹, 牧田 智, 岡本 眞宗, 小梛 地洋, 長島 俊介, 檜 顕成, 内田 広夫

    小児外科   Vol. 55 ( 7 ) page： 751 - 754   2023.7

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    Publisher：東京医学社  

    DOI： 10.24479/ps.0000000514

    CiNii Research

  56. IgG4-related disease of duodenal obstruction due to multiple ulcers in a 12-year-old girl Reviewed Open Access

    Kato, D; Uchida, H; Hinoki, A; Sumida, W; Shirota, C; Makita, S; Okamoto, M; Takimoto, A; Takada, S; Nakagawa, Y

    BMC PEDIATRICS   Vol. 23 ( 1 ) page： 376   2023.7

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  57. Case report: Laparoscopic gastrojejunostomy for duodenal atresia with situs inversus and preduodenal portal vein: a report of two cases Reviewed Open Access

    Nakagawa, Y; Sumida, W; Makita, S; Uchida, H; Hinoki, A; Shirota, C; Tainaka, T; Yokota, K; Amano, H; Yasui, A; Takimoto, A; Kato, D; Maeda, T; Gohda, Y

    FRONTIERS IN PEDIATRICS   Vol. 11   page： 1220393   2023.6

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  58. Case Report: Retropancreatic fascia hernia protruding into the thoracic cavity through a Bochdalek hernia Reviewed Open Access

    Nakagawa, Y; Maeda, T; Uchida, H; Takada, S; Hinoki, A; Shirota, C; Tainaka, T; Sumida, W; Makita, S; Amano, H; Takimoto, A; Gohda, Y

    FRONTIERS IN PEDIATRICS   Vol. 11   page： 1149515   2023.6

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  59. Preoperative Contrast Examinations Help Determine the Appropriate Cervical Approach for Congenital Gross Type C Esophageal Atresia: A Report of Two Cases. Reviewed Open Access

    Nakagawa Y, Uchida H, Shirota C, Tainaka T, Sumida W, Makita S, Amano H, Takimoto A, Ogata S, Takada S, Maeda T, Gohda Y, Guo Y, Hinoki A

    The American journal of case reports   Vol. 24   page： e938723   2023.6

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    Language：English  

    DOI： 10.12659/AJCR.938723

    PubMed

  60. CLINICAL VALIDATION OF NOVEL URINARY MARKERS FOR NEUROBLASTOMA DIAGNOSIS Reviewed

    Amano, H; Uchida, H; Harada, K; Narita, A; Kumano, S; Abe, M; Sakairi, M; Shirota, C; Tainaka, T; Sumida, W; Yokota, K; Makita, S; Osawa, T; Taguri, M; Takahashi, Y; Hinoki, A

    PEDIATRIC BLOOD & CANCER   Vol. 70   page： S95 - S95   2023.6

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  61. 特集 ロボット支援手術 ロボット支援下胆管切除術 Reviewed

    牧田 智, 内田 広夫, 住田 亙, 檜 顕成, 城田 千代栄, 田井中 貴久, 天野 日出, 滝本 愛太朗, 高田 瞬也, 中川 洋一, 合田 陽祐, 前田 拓也, 郭 垚輝, 劉 佳慧

    小児外科   Vol. 55 ( 5 ) page： 544 - 551   2023.5

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    Publisher：東京医学社  

    DOI： 10.24479/ps.0000000451

    CiNii Research

  62. Hemi-circumferential mucosal resection and anastomosis procedure for rectal prolapse following anorectoplasty for anorectal malformations Reviewed

    Takimoto, A; Amano, H; Shirota, C; Sumida, W; Makita, S; Okamoto, M; Ogata, S; Takada, S; Nakagawa, Y; Kato, D; Gohda, Y; Hinoki, A; Uchida, H

    SURGERY TODAY   Vol. 53 ( 5 ) page： 628 - 632   2023.5

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  63. Single-cell RNA sequencing of intestinal immune cells in neonatal necrotizing enterocolitis Reviewed Open Access

    Oshima, K; Hinoki, A; Uchida, H; Tanaka, Y; Okuno, Y; Go, Y; Shirota, C; Tainaka, T; Sumida, W; Yokota, K; Makita, S; Takimoto, A; Kano, Y; Sawa, S

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 39 ( 1 ) page： 179   2023.4

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  64. Rare case of a right Bochdalek hernia with retroperitoneal prolapse of organs into the thoracic cavity in infancy: A case report Reviewed

    Nakagawa, Y; Uchida, H; Hinoki, A; Shirota, C; Sumida, W; Makita, S; Amano, H; Masamune, O; Takimoto, A; Ogata, S; Takada, S; Kato, D; Gohda, Y; Guo, YH

    ASIAN JOURNAL OF ENDOSCOPIC SURGERY   Vol. 16 ( 2 ) page： 284 - 288   2023.4

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  65. Laparoscopic bile duct plasty for hilar bile duct stenosis (HBDS) in patients with congenital biliary dilatation: Diagnosis of HBDS by preoperative MRCP and laparoscopic strategy to relieve HBDS Reviewed

    Nakagawa, Y; Uchida, H; Hinoki, A; Shirota, C; Tainaka, T; Sumida, W; Makita, S; Yasui, A; Takimoto, A; Guo, YH

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 30 ( 4 ) page： 473 - 481   2023.4

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  66. Laparoscopic internal intestinal drainage of bile lakes in a patient with recurrence of jaundice after laparoscopic revision of Kasai portoenterostomy for biliary atresia: A case report Reviewed

    Gohda, Y; Uchida, H; Hinoki, A; Shirota, C; Sumida, W; Makita, S; Okamoto, M; Ogata, S; Takimoto, A; Takada, S; Nakagawa, Y; Kato, D; Guo, YH

    ASIAN JOURNAL OF ENDOSCOPIC SURGERY   Vol. 16 ( 2 ) page： 275 - 278   2023.4

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  67. Laparoscopic Duodenal-Caudal Detachment Method: Early Experience of a Novel Technique for Malrotation with Volvulus in Neonates Reviewed

    Takimoto, A; Amano, H; Sumida, W; Shirota, C; Yokota, K; Makita, S; Okamoto, M; Ogata, S; Takada, S; Nakagawa, Y; Kato, D; Goda, Y; Hinoki, A; Uchida, H

    JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES   Vol. 33 ( 2 ) page： 220 - 225   2023.2

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  68. Endoscopic injection sclerotherapy with polidocanol for cardiac varices in children and adolescents Reviewed Open Access

    Yokoyama, S; Ishizu, Y; Honda, T; Imai, N; Ito, T; Yamamoto, K; Hinoki, A; Sumida, W; Shirota, C; Tainaka, T; Makita, S; Yokota, K; Uchida, H; Ishigami, M

    ARCHIVES DE PEDIATRIE   Vol. 30 ( 2 ) page： 109 - 112   2023.2

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  69. A new type of retropancreatic fascia hernia in the supramesocolic space preoperatively misdiagnosed as a diaphragmatic hernia: report of two cases Reviewed Open Access

    Nakagawa, Y; Uchida, H; Makita, S; Yokota, K; Hinoki, A; Shirota, C; Tainaka, T; Sumida, W; Amano, H; Ogata, S; Takimoto, A; Takada, S; Maeda, T; Gohda, Y

    SURGICAL CASE REPORTS   Vol. 9 ( 1 ) page： 5   2023.1

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  70. Laparoscopic restorative proctocolectomy with ileal-J-pouch anal canal anastomosis without diverting ileostomy for total colonic and extensive aganglionosis is safe and feasible with combined Lugol's iodine staining technique and indocyanine green fluorescence angiography Reviewed Open Access

    Nakagawa, Y; Yokota, K; Uchida, H; Hinoki, A; Shirota, C; Tainaka, T; Sumida, W; Makita, S; Amano, H; Takimoto, A; Ogata, S; Takada, S; Maeda, T; Gohda, Y

    FRONTIERS IN PEDIATRICS   Vol. 10   page： 1090336   2023.1

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  71. The presence of high-risk varices after sclerotherapy in biliary atresia Reviewed Open Access

    Yokoyama, S; Ishizu, Y; Honda, T; Imai, N; Ito, T; Yamamoto, K; Shirota, C; Tainaka, T; Sumida, W; Makita, S; Takimoto, A; Nakagawa, Y; Takada, S; Ishigami, M; Uchida, H; Kawashima, H

    PEDIATRICS INTERNATIONAL   Vol. 65 ( 1 ) page： e15454   2023.1

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  72. Laparoscopic closure of Roux limb perforation during double-balloon endoscopic retrograde cholangiography with laparoscopy-assisted endoscopic hepatolithectomy 30 years after congenital biliary dilatation radical surgery: A case report Reviewed

    Nakagawa, Y; Uchida, H; Hinoki, A; Shirota, C; Sumida, W; Makita, S; Masamune, O; Ogata, S; Takimoto, A; Takada, S; Kato, D; Gohda, Y

    ASIAN JOURNAL OF ENDOSCOPIC SURGERY   Vol. 16 ( 1 ) page： 118 - 122   2023.1

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  73. Retroperitoneoscopic resection of a large paraganglioma surrounded by the right diaphragmatic crus on the dorsal side of the inferior vena cava: A pediatric case report Reviewed

    Takimoto, A; Sumida, W; Shirota, C; Makita, S; Okamoto, M; Ogata, S; Takada, S; Nakagawa, Y; Kato, D; Goda, Y; Hinoki, A; Uchida, H

    ASIAN JOURNAL OF ENDOSCOPIC SURGERY   Vol. 16 ( 1 ) page： 131 - 134   2023.1

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  74. 先天性十二指腸閉鎖症・狭窄症に合併した膵・胆管合流異常の4例 Reviewed Open Access

    牧田 智, 内田 広夫, 檜顕 成, 寺脇 幹, 城田 千代栄, 田井中 貴久, 住田 亙, 横田 一樹, 天野 日出, 滝本 愛太朗, 安井 昭洋, 中川 洋一, 加藤 大幾, 合田 陽祐, 前田 拓也, 郭 垚輝, 劉 佳慧

    日本膵・胆管合流異常研究会プロシーディングス   Vol. 46 ( 0 ) page： 52 - 53   2023

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    Language：Japanese   Publisher：日本膵・胆管合流異常研究会  

    DOI： 10.34410/jspbm.46.0_52

    Open Access

    CiNii Research

  75. 3D Digital Mapping by Affordable Mobile LiDAR Scanner Open Access

    Nakata Takashi, Hama Akira, Iwasa Yoshiya, Kumahara Yasuhiro, Goto Hideaki, Mori Wataru, Makita Tomohiro, Sugita Satoru, Suzuki Yasuhiro, Watanabe Mitsuhisa, Kagohara Kyoko

    Proceedings of the General Meeting of the Association of Japanese Geographers   Vol. 2023s ( 0 ) page： 179   2023

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    Language：Japanese   Publisher：The Association of Japanese Geographers  

    DOI： 10.14866/ajg.2023s.0_179

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    CiNii Research

  76. Refractory tracheoesophageal fistula treated using multi-stage surgery: A case report Reviewed Open Access

    Nakagawa, Y; Makita, S; Uchida, H; Hinoki, A; Shirota, C; Sumida, W; Amano, H; Okamoto, M; Takimoto, A; Ogata, S; Takada, S; Kato, D; Gohda, Y; Guo, YH

    FRONTIERS IN PEDIATRICS   Vol. 10   page： 1053154   2022.12

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  77. Preoperative imaging contributes to pathologically complete resection of the urachal remnant by determining an appropriate surgical approach without unnecessary and excessive surgical invasion: a retrospective study Reviewed Open Access

    Nakagawa, Y; Sumida, W; Amano, H; Uchida, H; Hinoki, A; Shirota, C; Makita, S; Okamoto, M; Ogata, S; Takimoto, A; Takada, S; Kato, D; Gohda, Y

    BMC UROLOGY   Vol. 22 ( 1 ) page： 207   2022.12

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  78. Laparoscopic revision of Kasai portoenterostomy after initial laparoscopic portoenterostomy in patients with biliary atresia: a limited but positive effect on native liver survival Reviewed Open Access

    Kato, D; Uchida, H; Amano, H; Hinoki, A; Shirota, C; Sumida, W; Yokota, K; Makita, S; Okamoto, M; Takimoto, A; Yasui, A; Takada, S; Nakagawa, Y

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 38 ( 12 ) page： 1821 - 1827   2022.12

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  79. Adding a spur valve to laparoscopic portoenterostomy for patients with biliary atresia can achieve a high jaundice clearance rate and lower the number of episodes of cholangitis Reviewed

    Yasui, A; Hinoki, A; Amano, H; Shirota, C; Tainaka, T; Sumida, W; Yokota, K; Makita, S; Okamoto, M; Takimoto, A; Nakagawa, Y; Uchida, H

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 38 ( 12 ) page： 1881 - 1885   2022.12

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  80. Biochemical markers to predict the development of gastrointestinal bleeding and esophageal varices after portoenterostomy in biliary atresia Reviewed Open Access

    Sumida, W; Tainaka, T; Shirota, C; Yokota, K; Makita, S; Okamoto, M; Takimoto, A; Yasui, A; Takada, S; Nakagawa, Y; Kato, D; Yokoyama, S; Ishizu, Y; Amano, H; Guo, YH; Hinoki, A; Uchida, H

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 38 ( 12 ) page： 1799 - 1805   2022.12

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  81. Combined negative pressure wound therapy with irrigation and dwell time and artificial dermis prevents infection and promotes granulation formation in a ruptured giant omphalocele: a case report Reviewed Open Access

    Nakagawa, Y; Uchida, H; Hinoki, A; Shirota, C; Sumida, W; Makita, S; Amano, H; Okamoto, M; Takimoto, A; Ogata, S; Takada, S; Kato, D; Gohda, Y

    BMC PEDIATRICS   Vol. 22 ( 1 ) page： 680   2022.11

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  82. Case report: A giant bilateral inguinal hernia requiring artificial mesh and multi-stage surgery in infancy; hernioplasty with silo placement to prevent acute compartment syndrome Reviewed Open Access

    Nakagawa, Y; Makita, S; Uchida, H; Hinoki, A; Shirota, C; Sumida, W; Amano, H; Okamoto, M; Takimoto, A; Yasui, A; Ogata, S; Takada, S; Kato, D; Gohda, Y; Yaohui, G

    FRONTIERS IN PEDIATRICS   Vol. 10   page： 1030934   2022.11

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  83. Intraoperative indocyanine green fluorescence cholangiography can rule out biliary atresia: A preliminary report Reviewed Open Access

    Shirota, C; Hinoki, A; Togawa, T; Ito, S; Sumida, W; Makita, S; Amano, H; Takimoto, A; Takada, S; Okamoto, M; Nakagawa, Y; Kato, D; Uchida, H

    FRONTIERS IN PEDIATRICS   Vol. 10   page： 1005879   2022.11

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  84. Circumumbilical incision for neonatal abdominal surgery: additional skin incision when there is difficulty in manipulating the intestine Reviewed Open Access

    Nakagawa, Y; Hinoki, A; Amano, H; Uchida, H; Shirota, C; Tainaka, T; Sumida, W; Yokota, K; Makita, S; Okamoto, M; Takimoto, A; Yasui, A; Takada, S; Kato, D

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 4 ) page： 716 - 722   2022.11

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  85. 特集 小児外科を取り巻く最新テクノロジー Hirschsprung病に対する機械学習を用いた病理診断支援システムの開発 Reviewed

    天野 日出, 木村 和恵, 今井 佑太, 加藤 竜司, 中澤 温子, 城田 千代栄, 滝本 愛太朗, 住田 亙, 牧田 智, 岡本 眞宗, 安井 昭洋, 高田 瞬也, 中川 洋一, 加藤 大幾, 檜 顕成, 内田 広夫

    小児外科   Vol. 54 ( 10 ) page： 1007 - 1011   2022.10

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    Publisher：東京医学社  

    DOI： 10.24479/ps.0000000254

    CiNii Research

  86. Laparoscopic definitive surgery for congenital biliary dilatation with aggressive hilar bile ductoplasty and complete resection of the intrapancreatic bile duct in pediatric patients is safe and effective, comparable to open surgery Reviewed

    Tainaka, T; Shirota, C; Hinoki, A; Sumida, W; Yokota, K; Makita, S; Amano, H; Tanaka, Y; Uchida, H

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   Vol. 36 ( 10 ) page： 7352 - 7359   2022.10

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  87. 特集 先天性胆道拡張症up-to-date 腹腔鏡下先天性胆道拡張症根治術中に膵管損傷した2例 Reviewed

    加藤 大幾, 檜 顕成, 城田 千代栄, 住田 亙, 牧田 智, 天野 日出, 岡本 眞宗, 尾形 誠弥, 滝本 愛太朗, 高田 瞬也, 中川 洋一, 合田 陽祐, 内田 広夫

    小児外科   Vol. 54 ( 9 ) page： 924 - 927   2022.9

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    DOI： 10.24479/ps.0000000238

    CiNii Research

  88. 特集 先天性胆道拡張症up-to-date 肝側合併症(肝内胆管狭窄)に対する肝内胆管形成術 Reviewed

    中川 洋一, 内田 広夫, 檜 顕成, 城田 千代栄, 住田 亙, 牧田 智, 岡本 眞宗, 尾形 誠弥, 滝本 愛太朗, 高田 瞬也, 加藤 大幾, 合田 陽祐

    小児外科   Vol. 54 ( 9 ) page： 904 - 907   2022.9

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    DOI： 10.24479/ps.0000000234

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  89. Evaluation of minimally invasive surgical skills training: comparing a neonatal esophageal atresia/tracheoesophageal fistula model with a dry box Reviewed

    Deie, K; Nakagawa, Y; Uchida, H; Hinoki, A; Shirota, C; Tainaka, T; Sumida, W; Yokota, K; Makita, S; Fujiogi, M; Okamoto, M; Takimoto, A; Yasui, A; Takada, S; Maeda, T

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   Vol. 36 ( 8 ) page： 6035 - 6048   2022.8

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  90. Thoracoscopic posterior tracheopexy during primary esophageal atresia repair ameliorate tracheomalacia in neonates: a single-center retrospective comparative cohort study Reviewed Open Access

    Yasui, A; Hinoki, A; Amano, H; Shirota, C; Tainaka, T; Sumida, W; Yokota, K; Makita, S; Okamoto, M; Takimoto, A; Nakagawa, Y; Uchida, H

    BMC SURGERY   Vol. 22 ( 1 ) page： 285   2022.7

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  91. Laparoscopic definitive surgery for choledochal cyst is performed safely and effectively in infants Reviewed Open Access

    Tainaka, T; Shirota, C; Sumida, W; Yokota, K; Makita, S; Amano, H; Okamoto, M; Takimoto, A; Kano, Y; Yasui, A; Nakagawa, Y; Hinoki, A; Uchida, H

    JOURNAL OF MINIMAL ACCESS SURGERY   Vol. 18 ( 3 ) page： 372 - 377   2022.7

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  92. Single-incision laparoscopic percutaneous extraperitoneal closure (SILPEC) for inguinal hernia with prolapsed ovary Reviewed

    Shirota, C; Tainaka, T; Sumida, W; Yokota, K; Makita, S; Amano, H; Okamoto, M; Takimoto, A; Yasui, A; Nakagawa, Y; Hinoki, A; Uchida, H

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   Vol. 36 ( 6 ) page： 4328 - 4332   2022.6

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    Background: Most studies reporting the outcomes of laparoscopic ovarian prolapsed hernia operations with large sample sizes are based on intracorporeal closure, while studies on extraperitoneal closure have limited sample sizes. We proactively used the single-incision laparoscopic percutaneous extraperitoneal closure (SILPEC) technique and obtained favorable outcomes, which we report in this paper. Methods: We retrospectively reviewed patients who had undergone laparoscopic surgery for inguinal hernia at our institution. They were retrospectively classified into two groups based on the pre- or intraoperative diagnosis of hernia with a prolapsed ovary, namely the prolapse group and the non-prolapse group, respectively. The data were statistically analyzed and p < 0.05 was considered statistically significant. Results: A total of 771 subjects underwent SILPEC during the study period, including 400 girls. Among them, 63 girls were diagnosed with an ovarian prolapsed hernia. SILPEC was successfully performed through a single port in all cases, with a single exception, in whom the forceps was inserted directly through the right lower quadrant to pull up the ovary. The duration of surgery in the prolapse group was not higher than that in the non-prolapse group. During the SILPEC surgery, the ovaries were successfully reverted into the abdominal cavity by external compression of the inguinal area alone in 38 of the 63 patients. In the remaining 25 cases, the ovaries were reverted into the abdominal cavity by external compression of the inguinal area and traction of the round ligament with forceps. None of these cases failed to return to the ovaries. Conclusion: Our study results indicate that SILPEC may be performed safely for the treatment of ovarian prolapsed inguinal hernia. Since the ovary and fallopian tube are close to the internal inguinal ring due to the short round ligament, the procedure requires careful suturing with traction of the round ligament.

    DOI： 10.1007/s00464-021-08777-4

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  93. Patients with gastric volvulus recurrence have high incidence of wandering spleen requiring laparoscopic gastropexy and splenopexy Reviewed Open Access

    Nakagawa, Y; Uchida, H; Amano, H; Hinoki, A; Tainaka, T; Shirota, C; Sumida, W; Yokota, K; Makita, S; Okamoto, M; Takimoto, A; Yasui, A; Takada, S; Kato, D

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 38 ( 6 ) page： 875 - 881   2022.6

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  94. METABOLOMICS OF URINARY METABOLITES IN CHILDHOOD RHABDOMYOSARCOMA TO DISCOVER NOVEL BIOMARKERS Reviewed

    Nakano, S; Uchida, H; Amano, H; Narita, A; Abe, M; Ishigaki, T; Sakairi, M; Shirota, C; Sumida, W; Makita, S; Takimoto, A; Okamoto, M; Yasui, A; Takada, S; Nakagawa, Y; Terui, Y; Sunagawa, M; Takahashi, Y; Osawa, T; Hinoki, A

    PEDIATRIC BLOOD & CANCER   Vol. 69   2022.6

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  95. Utility of endoscopic retrograde cholangiopancreatography in management of pediatric pancreaticobiliary disease Reviewed Open Access

    Makita, S; Amano, H; Kawashima, H; Hinoki, A; Shirota, C; Tainaka, T; Sumida, W; Yokota, K; Okamoto, M; Takimoto, A; Yasui, A; Nakagawa, Y; Uchida, H

    BMC PEDIATRICS   Vol. 22 ( 1 ) page： 134   2022.3

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  96. Safety and feasibility of primary radical surgery for meconium peritonitis considering patients' general condition and perioperative findings Reviewed Open Access

    Nakagawa, Y; Uchida, H; Amano, H; Hinoki, A; Shirota, C; Sumida, W; Yokota, K; Makita, S; Okamoto, M; Takimoto, A; Yasui, A; Takada, S; Maeda, T

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 1 ) page： 148 - 154   2022.2

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  97. Laparoscopic Kasai portoenterostomy can be a standard surgical procedure for treatment of biliary atresia Reviewed Open Access

    Shirota, C; Hinoki, A; Tainaka, T; Sumida, W; Kinoshita, F; Yokota, K; Makita, S; Amano, H; Nakagawa, Y; Uchida, H

    WORLD JOURNAL OF GASTROINTESTINAL SURGERY   Vol. 14 ( 1 ) page： 56 - 63   2022.1

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  98. 胆道拡張症術後肝内結石への DBERC 中に小腸穿孔をきたし、腹腔鏡下穿孔部閉鎖＋内視鏡下採石した1例 Reviewed Open Access

    中川 洋一, 内田 広夫, 檜 顕成, 城田 千代栄, 住田 亙, 牧田 智, 岡本 眞宗, 尾形 誠弥, 滝本 愛太朗, 高田 瞬也, 加藤 大幾, 合田 陽祐

    日本膵・胆管合流異常研究会プロシーディングス   Vol. 45 ( 0 ) page： 77 - 78   2022

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    DOI： 10.34410/jspbm.45.0_77

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  99. 多発肝内胆管狭窄を伴う先天性胆道拡張症術後難治性肝内結石の１例 Reviewed Open Access

    牧田 智, 内田 広夫, 檜 顕成, 城田 千代栄, 住田 亙, 天野 日出, 岡本 眞宗, 尾形 誠弥, 滝本 愛太朗, 高田 瞬也, 中川 洋一, 加藤 大幾, 合田 陽祐

    日本膵・胆管合流異常研究会プロシーディングス   Vol. 45 ( 0 ) page： 74 - 75   2022

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    DOI： 10.34410/jspbm.45.0_74

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  100. 特集 小児外科疾患の家族内発生 胆道閉鎖症の家族内発症 Reviewed

    安井 昭洋, 内田 広夫, 城田 千代栄, 住田 亙, 横田 一樹, 牧田 智, 岡本 眞宗, 滝本 愛太朗, 高田 瞬也, 中川 洋一

    小児外科   Vol. 53 ( 12 ) page： 1288 - 1290   2021.12

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    DOI： 10.24479/j00645.2022081278

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  101. An imaging study on tracheomalacia in infants with esophageal atresia: the degree of tracheal compression by the brachiocephalic artery is a good indicator for therapeutic intervention Reviewed Open Access

    Sumida, W; Tainaka, T; Shirota, C; Yokota, K; Makita, S; Takimoto, A; Yasui, A; Okamoto, M; Nakagawa, Y; Hinoki, A; Uchida, H

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 12 ) page： 1719 - 1724   2021.12

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    Purpose: Tracheomalacia (TM) is a frequent complication after esophageal atresia (EA) repair. This study aimed to review patients who underwent aortopexy for TM after EA repair and to compare their imaging features. Methods: The patients who underwent thoracoscopic EA repair and contrast-enhanced computed tomography (CECT) at our hospital between 2013 and 2020 were retrospectively reviewed. The ratio of the lateral and anterior–posterior diameter of the trachea (LAR) where the brachiocephalic artery (BCA) crosses the trachea was defined. The LAR of the patients who underwent CECT for asymptomatic pulmonary disease was set as a normal reference. The Z-score of each LAR was calculated and compared between the patients that did or did not undergo aortopexy. Results: A total of 51 patients represented the controls, 5 patients underwent aortopexy, and 12 patients were discharged without surgery. The mean LARs in the patients who underwent aortopexy, did not undergo aortopexy, and controls were 3.54, 1.54, and 1.15, respectively. The mean Z-score of the aortopexy group was 21.2. After successful aortopexy, each patient’s LAR decreased to < 1.5. Conclusion: Aortopexy was preferred if the trachea was compressed by the BCA. The LAR is a useful indicator for predicting the therapeutic effect of aortopexy.

    DOI： 10.1007/s00383-021-04985-0

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  102. Urinary N<SUP>1</SUP>,N<SUP>12</SUP>-diacetylspermine as a biomarker for pediatric cancer: a case-control study Reviewed Open Access

    Yokota, K; Hinoki, A; Hiramatsu, K; Amano, H; Kawamura, M; Kuwatsuka, Y; Tainaka, T; Shirota, C; Sumida, W; Makita, S; Okamoto, M; Takimoto, A; Yasui, A; Nakagawa, Y; Uchida, H; Kawakita, M

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 12 ) page： 1659 - 1665   2021.12

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    Purpose: Minimally invasive examinations are particularly important in pediatric patients. Although the significance of urinary N1,N12-diacetylspermine (DiAcSpm) as a tumor marker (TM) has been reported in many types of adult cancers, its usefulness in pediatric cancers has not been reported. This may be due to urinary DiAcSpm level variations with age. This study aims to measure the normal levels of urinary DiAcSpm in healthy individuals and investigate its usefulness as a TM in childhood cancer. Methods: Urinary samples were collected from pediatric patients with and without cancer. The urinary DiAcSpm levels were measured, and the values were compared. Results: A total of 32 patients with cancer and 405 controls were enrolled in the study. Of the 32 patients, 13 had neuroblastoma, 9 had malignant lymphoma (ML), and 10 had leukemia. In the control group, the urinary DiAcSpm values markedly fluctuated among those with young age, especially infants; meanwhile, the values converged among those aged roughly 10 years and above. The sensitivity of DiAcSpm was significantly different among the three types of cancers: neuroblastoma (30.8%), ML (77.8%), and leukemia (40%). Conclusion: The urinary DiAcSpm value is a useful TM for both screening and follow-up of ML.

    DOI： 10.1007/s00383-021-04987-y

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  103. Clinical characteristics and outcomes of the right congenital diaphragmatic hernia compared to the left: a 10-year single-center experience Reviewed Open Access

    Okamoto, M; Amano, H; Uchida, H; Hinoki, A; Tainaka, T; Shirota, C; Sumida, W; Yokota, K; Makita, S; Takimoto, A; Yasui, A; Nakagawa, Y

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 12 ) page： 1675 - 1681   2021.12

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    Purpose: The features of right-sided congenital diaphragmatic hernias (RCDHs) are quite different from those of left-sided CDHs (LCDHs). We have summarized the features of RCDHs experienced in our institution. Methods: This retrospective study analyzed the cases of patients with CDH registered at our institution between 2011 and 2020. Defects on each side were compared based on prenatal diagnosis, medical treatment, type of surgery, and outcomes. Results: A total of 101 patients underwent surgery at our institution during the neonatal period, and 11 had RCDHs. RCDHs and LCDHs were significantly different in terms of extracorporeal membrane oxygenation (36% vs. 6%, p = 0.002), patch repair (81% vs. 28%, p < 0.001), recurrence rate (36% vs. 11%, p = 0.022), and length of hospital stay (117 days vs. 51 days, p = 0.012). The severity of the fetal diagnosis did not reflect postnatal severity. All patients with RCDH survived to discharge, and there was no significant difference in survival rate between the right and left sides. Conclusion: Neonates with RCDH required more intensive treatments; however, the survival rate was comparable between RCDH and LCDH. RCDH was significantly different from LCDH and an optimal treatment strategy for RCDHs should be established.

    DOI： 10.1007/s00383-021-04999-8

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  104. Long-term outcomes of the partial splenectomy for hypersplenism after portoenterostomy of patients with biliary atresia Reviewed Open Access

    Tainaka, T; Hinoki, A; Tanaka, Y; Shirota, C; Sumida, W; Yokota, K; Makita, S; Oshima, K; Amano, H; Takimoto, A; Kano, Y; Uchida, H

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 4 ) page： 765 - 771   2021.11

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  105. Factors associated with bleeding after endoscopic variceal ligation in children Reviewed Open Access

    Yokoyama, S; Ishizu, Y; Ishigami, M; Honda, T; Kuzuya, T; Ito, T; Hinoki, A; Sumida, W; Shirota, C; Tainaka, T; Makita, S; Yokota, K; Uchida, H; Fujishiro, M

    PEDIATRICS INTERNATIONAL   Vol. 63 ( 10 ) page： 1223 - 1229   2021.10

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    Background: Endoscopic variceal ligation (EVL) is a widely accepted treatment for esophagogastric varices in patients with portal hypertension (PHT). It is used for urgent treatment and prophylactic treatment of esophagogastric varices in pediatric as well as adult patients. However, major life-threatening adverse events such as early rebleeding can occur. Although early rebleeding after EVL among children and adolescents has been reported, the risk factors remain obscure. This study evaluated the risk factors for early rebleeding after EVL in children and adolescents. Methods: The subjects were children and adolescents (<18 years) with PHT who underwent EVL for esophagogastric varices. Early rebleeding was defined as hematemesis, active bleeding, or blood retention in the stomach, confirmed by esophagogastroduodenoscopy from 2 h to 5 days after EVL. Results: A total of 50 EVL sessions on 22 patients were eligible for this study. There were four episodes of early rebleeding. No other major adverse event has occurred. Multivariate analysis showed that EVL implemented at cardiac varices just below the esophagogastric junction (EGJ), within 5 mm from the EGJ, is the independent factor for a higher risk of early rebleeding: odds ratio 18.2 (95% confidence interval: 1.40–237.0), P = 0.02. Conclusions: Children and adolescents who undergo EVL for cardiac varices just below the EGJ have a higher risk of early rebleeding than those who do not.

    DOI： 10.1111/ped.14614

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  106. Late postoperative complications of congenital biliary dilatation in pediatric patients: a single-center experience of managing complications for over 20 years Reviewed Open Access

    Amano, H; Shirota, C; Tainaka, T; Sumida, W; Yokota, K; Makita, S; Takimoto, A; Tanaka, Y; Hinoki, A; Kawashima, H; Uchida, H

    SURGERY TODAY   Vol. 51 ( 9 ) page： 1488 - 1495   2021.9

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    Purpose: To investigate late complications after surgery for congenital biliary dilatation (CBD). Methods: We retrospectively reviewed the patients treated for late postoperative complications of extrahepatic bile duct resection with bilioenteric anastomosis for CBD at our hospital between 1999 and 2019. Results: Twenty-seven complications, including bile duct stenosis with (n = 19) or without (n = 3) hepatolithiasis, remnant intrapancreatic bile duct (n = 2), intestinal obstruction (n = 2), and refractory cholangitis (n = 1) were treated in 26 patients. The median age at radical surgery and the initial treatment of complications was 3 years, 2 months and 14 years, 5 months, respectively. The median period from radical surgery to initial treatment of complications was 7 years, 1 month. Before 2013, bile duct stenosis was initially treated with bile duct plasty (n = 11) or hepatectomy (n = 3), and 71.4% (n = 10) of patients needed further treatment; after 2013, double-balloon endoscopic retrograde cholangiography (DBERC) was used (n = 8), and 25% (n = 2) of patients needed further treatment. Patients with remnant intrapancreatic bile duct, intestinal obstruction, and refractory cholangitis required surgery. Conclusion: Long-term follow-up is necessary after surgery for congenital biliary dilatation. DBERC is thus considered to be useful for bile duct stenosis management.

    DOI： 10.1007/s00595-021-02238-0

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  107. Laparoscopic One-Stage Radical Surgery for Congenital Biliary Dilatation With Biliary Perforation Reviewed Open Access

    Ishii Hiroki, Makita Satoshi, Yasui Akihiro, Takimoto Aitaro, Yokota Kazuki, Sumida Wataru, Tainaka Takahisa, Shirota Chiyoe, Uchida Hiroo

    Journal of the Japanese Society of Pediatric Surgeons   Vol. 57 ( 5 ) page： 855 - 859   2021.8

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    <p>A 21-month-old girl with chief complaints of vomiting and fever was admitted to a hospital and diagnosed as having congenital biliary dilatation. Magnetic resonance imaging performed on the sixth day of hospitalization revealed bile duct perforation, and the patient was transferred to our department for further treatment. A perforation approximately 2 cm in diameter was found at the confluence of the common bile duct and cystic duct. We concluded that biliary drainage and repair of the perforation would not improve her pathophysiology. Therefore, laparoscopic one-stage radical surgery was performed. In addition, bile duct plasty was performed to treat the severe intrahepatic bile duct membranous stenosis that were observed in the right and left bile ducts of the hepatic hilum. The patient was discharged without complications on the tenth postoperative day.</p><p>Two-stage surgery is the recommended treatment method for congenital biliary dilatation with biliary perforation. However, in recent years, there have been few reports showing that one-stage open radical surgery is useful. In this case, we successfully performed laparoscopic one-stage radical surgery for congenital biliary dilatation with biliary perforation. If laparoscopic radical surgery for congenital biliary dilatation is established at the institution, and the patient is in good general condition, laparoscopic one-stage radical surgery may be an effective modality for treating this condition.</p>

    DOI： 10.11164/jjsps.57.5_855

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  108. Rhabdomyosarcoma Resected by Multidisciplinary Treatment: A Case Report Reviewed Open Access

    Kato Daiki, Makita Satoshi, Uemura Norihisa, Nakano Satoshi, Arai Toshiyuki, Miyajima Yuji

    Journal of the Japanese Society of Pediatric Surgeons   Vol. 57 ( 5 ) page： 878 - 883   2021.8

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    <p>A 13-year-old girl who presented with left lower abdominal pain was referred to our hospital. Enhanced abdominal CT revealed a 130 mm tumor in the pelvis invading the left ureter and the left iliac artery and vein. We performed laparoscopic-assisted biopsy, and on the basis of biopsy findings, we diagnosed the patient as having rhabdomyosarcoma. We performed radical resection because we confirmed that the tumor had shrank after chemoradiotherapy. We resected the tumor together with the left ureter and the left iliac artery and vein, and we reconstructed the left common iliac artery using an artificial graft and anastomosed the left ureter to the right ureter (transureteroureterostomy). The patient was administered surgical adjuvant chemotherapy, and she is now healthy at 3 years and 3 months after the surgery with no sign of recurrence. We experienced treating a case of retroperitoneal primary rhabdomyosarcoma invading the left ureter and left iliac artery and vein with a good prognosis by multidisciplinary treatment. The cooperation with specialists of each department seems to provide a safe and useful treatment, even for rhabdomyosarcoma requiring the resection of a combination of major blood vessels and ureters.</p>

    DOI： 10.11164/jjsps.57.5_878

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  109. Development of a novel diagnostic system for bile duct cancer using urinary metabolites. Reviewed

    Amano, H; Hinoki, A; Uchida, H; Yokota, K; Ishigaki, T; Sakairi, M; Abe, M; Terui, Y; Oda, H; Tainaka, T; Shirota, C; Sumida, W; Makita, S; Takimoto, A; Okamoto, M; Yasui, A; Nakagawa, Y

    CANCER RESEARCH   Vol. 81 ( 13 )   2021.7

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  110. Postoperative intestinal obstruction in patients with biliary atresia impedes biliary excretion and results in subsequent liver transplantation (vol 37, pg 229, 2021) Reviewed Open Access

    Takimoto, A; Sumida, W; Amano, H; Shirota, C; Tainaka, T; Yokota, K; Makita, S; Yasui, A; Kanou, Y; Hinoki, A; Uchida, H

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 6 ) page： 835 - 835   2021.6

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    A correction to this paper has been published: https://doi.org/10.1007/s00383-021-04873-7.

    DOI： 10.1007/s00383-021-04873-7

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  111. NOVEL BIOMARKER DISCOVERY FOR CHILDHOOD RHABDOMYOSARCOMA USING URINARY METABOLITES Reviewed

    Amano, H; Hinoki, A; Uchida, H; Yokota, K; Ishigaki, T; Sakairi, M; Abe, M; Terui, Y; Oda, H; Tainaka, T; Shirota, C; Sumida, W; Makita, S; Takimoto, A; Kano, Y; Okamoto, M; Yasui, A; Nakagawa, Y

    PEDIATRIC BLOOD & CANCER   Vol. 68   page： S46 - S46   2021.6

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  112. Double-balloon endoscopic retrograde cholangiography can make a reliable diagnosis and good prognosis for postoperative complications of congenital biliary dilatation Reviewed Open Access

    Shirota, C; Kawashima, H; Tainaka, T; Sumida, W; Yokota, K; Makita, S; Amano, H; Takimoto, A; Hinoki, A; Uchida, H

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page： 11052   2021.5

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    Bile duct and anastomotic strictures and intrahepatic stones are common postoperative complications of congenital biliary dilatation (CBD). We performed double-balloon endoscopic retrograde cholangiography (DBERC) for diagnostic and therapeutic purposes after radical surgery. We focused on the effectiveness of DBERC for the treatment of postoperative complications of CBD patients. Bile duct and anastomotic strictures and intrahepatic stones are common postoperative complications of congenital biliary dilatation (CBD). We performed double-balloon endoscopic retrograde cholangiography (DBERC) for diagnostic and therapeutic purposes after radical surgery. We focused on the effectiveness of DBERC for the treatment of postoperative complications of CBD patients. This retrospective study included 28 patients who underwent DBERC (44 procedures) after radical surgery for CBD between January 2011 and December 2019. Strictures were diagnosed as “bile duct strictures” if endoscopy confirmed the presence of bile duct mucosa between the stenotic and anastomotic regions, and as “anastomotic strictures” if the mucosa was absent. The median patient age was 4 (range 0–67) years at the time of primary surgery for CBD and 27.5 (range 8–76) years at the time of DBERC. All anastomotic strictures could be treated with only by 1–2 courses of balloon dilatation of DBERC, while many bile duct strictures (41.2%) needed ≥ 3 treatments, especially those who underwent operative bile duct plasty as the first treatment (83.3%). Although the study was limited by the short follow-up period after DBERC treatment, DBERC is recommended as the first-line treatment for hepatolithiasis associated with biliary and anastomotic strictures in CBD patients, and it can be safely performed multiple times.

    DOI： 10.1038/s41598-021-90550-7

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  113. 特集 シミュレーションとナビゲーション 精索静脈瘤 Reviewed

    田井中 貴久, 田中 裕次郎, 檜 顕成, 城田 千代栄, 住田 亙, 横田 一樹, 牧田 智, 内田 広夫

    小児外科   Vol. 53 ( 5 ) page： 560 - 563   2021.5

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    DOI： 10.24479/j00645.2021229976

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  114. Urinary biomarkers for monitoring treatment response in neuroblastoma patients. Reviewed

    Amano, H; Hinoki, A; Uchida, H; Yokota, K; Ishigaki, T; Sakairi, M; Abe, M; Takahashi, Y; Narita, A; Tainaka, T; Shirota, C; Sumida, W; Makita, S; Takimoto, A; Kano, Y; Yasui, A; Okamoto, M; Nakagawa, Y

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 39 ( 15 )   2021.5

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  115. A Retrospective Study on the Effect of Surgical Experiences of Laparoscopic Kasai Portenterostomy Reviewed Open Access

    Kurano Yui, Shirota Chiyoe, Hinoki Akinari, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Uchida Hiroo

    Journal of the Japanese Society of Pediatric Surgeons   Vol. 57 ( 3 ) page： 596 - 599   2021.4

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    <p><i>Purpose</i>: The treatment outcomes of patients with laparoscopic surgery for biliary atresia (laparoscopic portoenterostomy) were retrospectively evaluated to determine whether to limit the laparoscopic surgery for biliary atresia to fully experienced surgeons.</p><p><i>Methods</i>: We included 37 patients with laparoscopic portoenterostomy for biliary atresia at our institution from 2014 to 2018. Twelve patients were treated by a surgeon fully experienced in laparoscopic portoenterostomy (Group A) and 23 patients were treated by other surgeons (Group B). Jaundice reduction and jaundice-free survival of patients with the native liver in the two groups were compared.</p><p><i>Results</i>: Differences in age at the time of surgery, body weight, perioperative blood loss, time of drain removal, and time that milk or formula feeding resumed in both groups were not significant. The duration of surgery was significantly shorter in Group A than in Group B. The jaundice-free survival rates of patients with the native liver were 58.3% in Group A and 60.9% in Group B at 6 months after surgery, 66.7% in Group A and 65.2% in Group B at 1 year after surgery, and 58.3% in Group A and 56.5% in Group B at 2 years after surgery. No significant difference was observed.</p><p><i>Conclusions</i>: In this study, no significant difference in the rate of jaundice-free survival of patients with the native liver depending on the amount of surgical experience was observed under the guidance of an operator who was skilled in laparoscopic portoenterostomy.</p>

    DOI： 10.11164/jjsps.57.3_596

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  116. One-Stage Functional End-To-End Anastomosis Followed by Sutureless Abdominal Wall Closure for Colonic Atresia With Gastroschisis Reviewed Open Access

    Chiba Kosuke, Tanaka Yujiro, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Oshima Kazuo, Makita Satoshi, Uchida Hiroo

    Journal of the Japanese Society of Pediatric Surgeons   Vol. 57 ( 1 ) page： 22 - 26   2021.2

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    <p>The patient was a newborn female with colonic atresia and gastroschisis. A silo was placed immediately after birth and surgery was scheduled the following day. Adhesive detachment was performed by washing the intestinal tract with saline. The oral and anal segments of the colonic atresia were identified, and functional end-to-end anastomosis was performed. Severe edema precluded the immediate return of the intestines to the abdominal cavity and required ongoing treatment with a silo. The intestines gradually returned to the abdominal cavity during the following week. The abdominal wall was closed on postnatal day 9 by a sutureless method. The patient’s postoperative course was good, and full feeding was initiated on postnatal day 19. The patient was discharged from the hospital on postnatal day 32 and recovered without complications. In cases of gastroschisis with colonic atresia, a two-stage surgical procedure is commonly employed. However, functional end-to-end anastomosis using a linear stapler is also an effective method because anastomoses can be performed without regard to differences in intestinal caliber.</p>

    DOI： 10.11164/jjsps.57.1_22

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  117. Identification of novel neuroblastoma biomarkers in urine samples Reviewed Open Access

    Yokota, K; Uchida, H; Sakairi, M; Abe, M; Tanaka, Y; Tainaka, T; Shirota, C; Sumida, W; Oshima, K; Makita, S; Amano, H; Hinoki, A

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page： 4055   2021.2

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    Urine is a complex liquid containing numerous small molecular metabolites. The ability to non-invasively test for cancer biomarkers in urine is especially beneficial for screening child patients. This study attempted to identify neuroblastoma biomarkers by comprehensively analysing urinary metabolite samples from children. A total of 87 urine samples were collected from 54 participants (15 children with neuroblastoma and 39 without cancer) and used to perform a comprehensive analysis. Urine metabolites were extracted using liquid chromatography/mass spectrometry and analysed by Metabolon, Inc. Biomarker candidates were extracted using the Wilcoxon rank sum test, random forest method (RF), and orthogonal partial least squares discriminant analysis (OPLS-DA). RF identified three important metabolic pathways in 15 samples from children with neuroblastoma. One metabolite was selected from each of the three identified pathways and combined to create a biomarker candidate (3-MTS, CTN, and COR) that represented each of the three pathways; using this candidate, all 15 cases were accurately distinguishable from the control group. Two cases in which known biomarkers were negative tested positive using this new biomarker. Furthermore, the predictive value did not decrease in cases with a low therapeutic effect. This approach could be effectively applied to identify biomarkers for other cancer types.

    DOI： 10.1038/s41598-021-83619-w

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  118. Postoperative intestinal obstruction in patients with biliary atresia impedes biliary excretion and results in subsequent liver transplantation Reviewed Open Access

    Takimoto, A; Sumida, W; Amano, H; Shirota, C; Tainaka, T; Yokota, K; Makita, S; Yasui, A; Kanou, Y; Hinoki, A; Uchida, H

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 2 ) page： 229 - 234   2021.2

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    Purpose: This study aimed to investigate the negative effects of intestinal obstruction for jaundice-free native liver survival after Kasai portoenterostomy (PE) for biliary atresia (BA). Methods: We retrospectively reviewed the records of patients who underwent PE for BA between 2006 and 2019. We evaluated the postoperative morbidity of intestinal obstruction for up to 2 years after PE and the effects of intestinal obstruction on jaundice-free native liver survival. On the basis of their initial operation, patients were divided into open portoenterostomy (Open-PE) and laparoscopic portoenterostomy (Lap-PE) groups, and morbidity was compared. Results: Of the 87 patients reviewed, 6 (6.9%) patients developed postoperative intestinal obstruction and underwent surgery to relieve the obstruction. The morbidity of early postoperative intestinal obstruction was 1.68 per 10,000 person days. The jaundice-free native liver survival rate among patients who once achieved jaundice-free status after PE was significantly lower in the patients with intestinal obstruction compared to in those without intestinal obstruction (0% vs. 73.8%; RR = 3.81, p = 0.007). No significant differences were seen in postoperative intestinal obstructions between the Open-PE and Lap-PE groups (p = 0.242). Conclusions: Intestinal obstruction negatively impact jaundice-free native liver survival, even in patients who once achieved jaundice-free status after PE for BA.

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  119. Thoracoscopic surgery for congenital lung cysts: an attempt to limit pulmonary resection in cases of lesions involving multiple lobes Reviewed Open Access

    Shirota, C; Tainaka, T; Sumida, W; Yokota, K; Makita, S; Takimoto, A; Amano, H; Hinoki, A; Ono, Y; Uchida, H

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 2 ) page： 213 - 221   2021.2

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    Purpose: Although we generally perform thoracoscopic lobectomy for congenital lung cysts (CLCs), we recently began performing thoracoscopic-limited pulmonary resection (segmentectomy or small partial lung resection) on relatively small lesions and on lesions involving multiple lobes. Our study aimed to determine the therapeutic outcomes of thoracoscopic CLC surgery. Methods: We retrospectively reviewed patients aged ≤ 18 years who underwent their first CLC surgery at our facility between 2013 and 2020. Results: A comparison between patients < 4 months old and those ≥ 4 months old showed no significant difference in operating time or incidence of complications. Blood loss volume (mL/kg) was significantly greater in patients < 4 months old and in patients who had undergone semi-urgent or urgent surgery. Operating time and postoperative complications were not increased in semi-urgent or urgent surgeries. There was no significant difference in operating time, blood loss volume, or postoperative complications between patients with a preoperative history of pneumonia and patients with no such history. Conclusion: In most patients, thoracoscopic surgery for CLC was safely performed. Limited pulmonary resection is considered difficult to perform thoracoscopically in children, but can be safely performed using new devices and navigation methods. Level of evidence: III.

    DOI： 10.1007/s00383-020-04793-y

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  120. Risk factors and outcomes of bile leak after laparoscopic surgery for congenital biliary dilatation Reviewed Open Access

    Tanaka, Y; Tainaka, T; Hinoki, A; Shirota, C; Sumida, W; Yokota, K; Oshima, K; Makita, S; Amano, H; Takimoto, A; Kano, Y; Uchida, H

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 2 ) page： 235 - 240   2021.2

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    Purpose: One of the main causes of stricture at hepaticojejunostomy site after surgery for congenital biliary dilatation is inflammation or infection associated with bile leak. The aim of this study was to determine the risk factors and outcomes of bile leak after laparoscopic surgery. Methods: We retrospectively reviewed the demographics and outcomes of patients who underwent laparoscopic surgery for congenital biliary dilatation between September 2013 and December 2019. Data from patients with bile leak were compared to data from patients without bile leak. Results: Fourteen of 78 patients had bile leak. Hepatic duct diameter at anastomosis was the only risk factor of bile leak. Patients with the diameter ≤ 10 mm had higher incidence of bile leak than in patients with the diameter > 10 mm (P = 0.0023). Among them, bile leak occurred more frequently in patients operated on by non-qualified surgeons based on the Japan Society for Endoscopic Surgery endoscopic surgical skill qualification system than by qualified surgeons (P = 0.027). However, none of the patients with bile leak developed anastomotic stricture afterwards. Conclusion: Although good technical skill is necessary to avoid bile leak in narrow hepatic duct cases (≤ 10 mm), slight bile leak may not result in anastomotic stricture.

    DOI： 10.1007/s00383-020-04791-0

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  121. 先天性胆道拡張症の晩期合併症についての検討 Reviewed Open Access

    城田 千代栄, 天野 日出, 檜 顕成, 住田 亙, 横田 一樹, 牧田 智, 岡本 眞宗, 滝本 愛太朗, 安井 昭洋, 高田 瞬也, 中川 洋一, 前田 拓也, 内田 広夫

    日本膵・胆管合流異常研究会プロシーディングス   Vol. 44 ( 0 ) page： 50 - 51   2021

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    DOI： 10.34410/jspbm.44.0_50

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  122. 先天性胆道拡張症において術前MRI 画像による胆管狭窄部位の予測と術中胆管形成の検討 Reviewed Open Access

    中川 洋一, 内田 広夫, 檜 顕成, 城田 千代栄, 住田 亙, 横田 一樹, 牧田 智, 岡本 眞宗, 滝本 愛太朗, 安井 昭洋, 高田 舜也, 前田 拓也

    日本膵・胆管合流異常研究会プロシーディングス   Vol. 44 ( 0 ) page： 72 - 73   2021

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    DOI： 10.34410/jspbm.44.0_72

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  123. 特集 小児がん手術の問題点-わたしはここを重視している 当院での腹腔鏡下腫瘍生検の実際 Reviewed

    住田 亙, 田井中 貴久, 城田 千代栄, 横田 一樹, 牧田 智, 滝本 愛太朗, 安井 昭洋, 天野 日出, 石井 宏樹, 檜 顕成, 内田 広夫

    小児外科   Vol. 52 ( 12 ) page： 1331 - 1335   2020.12

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    DOI： 10.24479/j00645.2021085587

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  124. A novel Lugol's iodine staining technique to visualize the upper margin of the surgical anal canal intraoperatively for Hirschsprung disease: a case series Reviewed Open Access

    Yokota, K; Amano, H; Kudo, T; Yamamura, T; Tanaka, Y; Tainaka, T; Shirota, C; Sumida, W; Makita, S; Takimoto, A; Nakamura, M; Fujishiro, M; Hinoki, A; Uchida, H

    BMC SURGERY   Vol. 20 ( 1 ) page： 317   2020.12

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    Background: In cases of Hirschsprung disease, complete and reproducible resection of the aganglionic bowel is ideal to achieve good postoperative bowel function. Reliable identification of the upper margin of the surgical anal canal, which is the squamous-columnar junction, is necessary during transanal pull-through. Here, we describe a novel staining technique using Lugol’s iodine stain to visualize the upper margin of the surgical anal canal. Methods: Lugol’s iodine staining was performed in five patients with Hirschsprung disease treated using a single-stage laparoscopic transanal pull-through modified Swenson procedure. In two of these patients, endocytoscopic observation with ultra-high magnification was performed using methylene blue and crystal violet to mark the border of the squamous epithelium at 1 week before surgery. The alignment between the incisional line, which was revealed using Lugol’s iodine staining and endocytoscopic marking, was evaluated. Complications, including postoperative bowel dysfunction, were evaluated. Results: In all cases, Lugol’s iodine staining produced a well-demarcated line. The endocytoscopic marking of the upper margin of the surgical anal canal was aligned with the line revealed by Lugol’s iodine staining. There were no complications associated with the transanal pull-through procedure, including postoperative bowel dysfunction. Conclusions: Lugol’s iodine staining could be a safe and practical method to visualize the upper margin of the surgical anal canal intraoperatively. This finding may be useful for surgeons to make a consistent removal of the aganglionic bowel during surgery for Hirschsprung disease.

    DOI： 10.1186/s12893-020-00986-3

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  125. Laparoscopic Kasai portoenterostomy is advantageous over open Kasai portoenterostomy in subsequent liver transplantation Reviewed

    Shirota, C; Murase, N; Tanaka, Y; Ogura, Y; Nakatochi, M; Kamei, H; Kurata, N; Hinoki, A; Tainaka, T; Sumida, W; Yokota, K; Makita, S; Oshima, K; Uchida, H

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   Vol. 34 ( 8 ) page： 3375 - 3381   2020.8

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    Background: Native liver survival after laparoscopic Kasai portoenterostomy (Lap-PE) for biliary atresia (BA) is controversial. We examined whether a jaundice-free native liver survival rate is comparable between conventional Kasai portoenterostomy (Open-PE) and Lap-PE. Then, the impact of the two types of PE on subsequent living-donor liver transplantation (LTx) was addressed in this study. Methods: The jaundice-free rate in 1- and 2-year-old patients who underwent Open-PE and Lap-PE from January 2006 to December 2017 was investigated. Additionally, perioperative data (duration from the start of surgery to the completion of hepatectomy and others) of patients aged 2 years or younger who underwent LTx after either Open-PE or Lap-PE from 2006 to 2017 were evaluated. Results: Thirty-one (67%) out of 46 Open-PE patients and 23 (77%) out of 30 Lap-PE patients showed native liver survival with jaundice-free status at 1 year of age (p = 0.384); 29 (63%) out of 46 Open-PE patients and 19 (70%) out of 27 Lap-PE patients showed native liver survival with jaundice-free status at 2 years of age (p = 0.524); there were no significant differences. Additionally, there were 37 LTx cases after PE within 2 years of birth, including 29 Open-PE and 8 Lap-PE cases. The patients in the Lap-PE group had fewer adhesions and significantly shorter durations of surgery up to the completion of the recipient’s hepatectomy and durations of post-LTx hospital stay compared to the Open-PE group. There were no differences in blood loss or duration of stay in intensive care unit between the Lap-PE and Open-PE groups. Conclusions: Jaundice-free native liver survival rate has been comparable between Open-PE and Lap-PE. Lap-PE resulted in fewer adhesions, contributing to better outcomes of subsequent LTx compared to Open-PE.

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  126. Single-Port Laparoscopic-Assisted Surgery for Perforation of Ileac Duplication: A Case Report Reviewed Open Access

    Kato Daiki, Seki Takashi, Okamoto Masamune, Makita Satoshi, Arai Toshiyuki

    Journal of the Japanese Society of Pediatric Surgeons   Vol. 56 ( 3 ) page： 330 - 334   2020.6

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    <p>A 6-year-old boy who presented with abdominal pain was referred to our hospital. Enhanced abdominal CT revealed free gases in the abdominal cavity. We diagnosed him as having acute peritonitis owing to gastrointestinal perforation, but we were unable to identify the perforation site preoperatively. We performed emergency single-port laparoscopic-assisted surgery using a multichannel port (two 5-mm ports) with umbilical Benz incision. We identified the inflammatory ileum and pulled it out. A cystic lesion, with a hole at the base, was detected about 40 cm proximal to the end of the ileum. We partially resected the ileum. A histopathological examination revealed perforation of ileac duplication, which is rare and its preoperative diagnosis is difficult. We performed the single-port laparoscopic-assisted surgery without wound extension. The single-port laparoscopic-assisted surgery with the Benz incision is useful for the diagnosis and treatment of pediatric acute abdomen.</p>

    DOI： 10.11164/jjsps.56.3_330

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  127. Safe diagnostic management of malignant mediastinal tumors in the presence of respiratory distress: a 10-year experience Reviewed Open Access

    Tanaka, T; Amano, H; Tanaka, Y; Takahashi, Y; Tajiri, T; Tainaka, T; Shirota, C; Sumida, W; Yokota, K; Makita, S; Tani, Y; Hinoki, A; Uchida, H

    BMC PEDIATRICS   Vol. 20 ( 1 ) page： 292   2020.6

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    Background: The fundamental treatment for patients with pediatric malignant mediastinal tumors is chemotherapy. Therefore, accurate diagnosis is essential for selecting the appropriate chemotherapeutic regimen. However, malignant mediastinal tumors occasionally cause respiratory distress, and biopsies under general anesthesia are dangerous for such patients as invasive mechanical ventilation can aggravate airway obstruction caused by mass effect. In this study, we reviewed our 10-year diagnostic experience to evaluate the efficacy of our practices and confirm a safe diagnostic protocol for future patients. Methods: We retrospectively reviewed medical records of children with malignant mediastinal tumors diagnosed at Nagoya University Hospital from 2007 to 2018 who demonstrated respiratory distress. Respiratory distress included dyspnea, massive pleural effusion, wheezing, and hypoxemia owing to tumors. Data on sex, age at onset, primary symptoms, location of tumor, management strategy (especially the method of diagnosis and definitive diagnosis), clinical course, prognosis during the acute phase (within 3 months from the onset of respiratory symptoms), and long-term outcome were collected. Results: Twelve pediatric patients met the review criteria. There were seven anterior mediastinal tumors and five posterior mediastinal tumors. All anterior mediastinal tumors were diagnosed via bone marrow smear, thoracentesis, or core needle biopsy while maintaining spontaneous breathing. Regarding posterior tumors, two patients were diagnosed via a core needle biopsy and lymph node excisional biopsy under spontaneous breathing. Two cases were initially diagnosed solely using tumor markers. One patient with severe tracheal compression underwent tumor resection with extracorporeal membrane oxygenation stand-by. No patient died of diagnostic procedure-related complications. Conclusions: In 11 of the 12 cases reviewed, safe and accurate tumor diagnosis was accomplished without general anesthesia. A diagnostic strategy without general anesthesia considering the tumor location proved to be useful.

    DOI： 10.1186/s12887-020-02183-w

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  128. 特集 Hirschsprung病手術の現在 腹腔鏡補助下Swenson法 Reviewed

    横田 一樹, 内田 広夫, 田井中 貴久, 城田 千代栄, 住田 亙, 牧田 智, 大島 一夫, 滝本 愛太朗, 狩野 陽子

    小児外科   Vol. 52 ( 4 ) page： 369 - 373   2020.4

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    DOI： 10.24479/j00645.2020230886

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  129. 術中膵管損傷に対して内視鏡的に膵管ステントを挿入した1例 Reviewed Open Access

    城田 千代栄, 田井中 貴久, 住田 亙, 横田 一樹, 牧田 智, 天野 日出, 滝本 愛太朗, 安井 昭洋, 石井 宏樹, 檜 顕成, 内田 広夫

    日本膵・胆管合流異常研究会プロシーディングス   Vol. 43 ( 0 ) page： 84 - 85   2020

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    DOI： 10.34410/jspbm.43.0_84

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  130. 小児腹腔鏡手術における肝内胆管形成術 Reviewed Open Access

    田井中 貴久, 城田 千代栄, 住田 亙, 横田 一樹, 牧田 智, 滝本 愛太朗, 安井 昭洋, 石井 宏樹, 檜 顕成, 内田 広夫

    日本膵・胆管合流異常研究会プロシーディングス   Vol. 43 ( 0 ) page： 36 - 36   2020

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    DOI： 10.34410/jspbm.43.0_36

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  131. Identification and Validation of Novel Non-invasive Biomarkers in Patient Urine Samples for Diagnosis of New and Recurrent Neuroblastoma Reviewed

    Yokota, K; Uchida, H; Hinoki, A; Sakairi, M; Abe, M; Tanaka, Y; Tainaka, T; Shirota, C; Sumida, W; Oshima, K; Makita, S; Takimoto, A; Kano, Y; Inada, K

    PEDIATRIC BLOOD & CANCER   Vol. 66   page： S106 - S106   2019.12

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  132. 特集 ピーンチ!私はこうして切り抜けた 胆道閉鎖症　腹腔鏡手術中に門脈から出血 Reviewed

    内田 広夫, 田中 裕次郎, 田井中 貴久, 城田 千代栄, 住田 亙, 牧田 智, 横田 一樹, 滝本 愛太郎, 大島 一夫, 狩野 陽子, 稲田 亘佑

    小児外科   Vol. 51 ( 10 ) page： 1020 - 1023   2019.10

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    DOI： 10.24479/j00645.2020041175

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  133. Efficacy of and prognosis after steroid pulse therapy in patients with poor reduction of jaundice after laparoscopic Kasai portoenterostomy Reviewed

    Tanaka, Y; Shirota, C; Tainaka, T; Sumida, W; Oshima, K; Makita, S; Tanaka, T; Tani, Y; Chiba, K; Uchida, H

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 35 ( 10 ) page： 1059 - 1063   2019.10

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    Purpose: High-dose postoperative steroid therapy after Kasai portoenterostomy is reported to improve jaundice clearance and a strong anti-inflammatory activity might prevent fibrous tissue formation which is often observed at the porta hepatis in revision surgery. We started steroid pulse therapy for the patients with cessation of decrease in jaundice and aimed to evaluate the efficacy in this study. Methods: The demographics and outcomes of patients who underwent laparoscopic Kasai portoenterostomy and received steroid pulse therapy within 2 months postoperatively between September 2014 and December 2018 were retrospectively reviewed; the therapy was determined successful when the serum total bilirubin level decreased to or below two-thirds of the pre-therapy level after 2 weeks. Patient data in the successful group were compared with those in the unsuccessful group. Results: Steroid pulse therapy was successful in seven of 16 patients (43.8%). The percentage of patients whose serum total bilirubin level decreased to normal was significantly higher in the successful group at 3 months (85.7% vs. 11.1%, P = 0.0028) and after all (100% vs. 33.3%, P = 0.011). Conclusions: Steroid pulse therapy was effective for some patients. Unsuccessful cases may have little chances of jaundice clearance; revision Kasai portoenterostomy would be a good option.

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  134. Therapeutic strategy for thoracoscopic repair of esophageal atresia and its outcome Reviewed

    Shirota, C; Tanaka, Y; Tainaka, T; Sumida, W; Yokota, K; Makita, S; Oshima, K; Tanaka, T; Tani, Y; Uchida, H

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 35 ( 10 ) page： 1071 - 1076   2019.10

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    Purpose: Thoracoscopic repair can be safely performed in most types of congenital esophageal atresia (EA), including in patients with long gap EA or very low birth weight. Accordingly, we performed single- or multistage thoracoscopic repair for various EA types. We aimed to report our therapeutic strategy for thoracoscopic radical surgery for treating EA and its outcome. Methods: Outcomes of radical surgeries for treating congenital EA at our institute from 2013 to 2018 were retrospectively evaluated. Results: Thirty-eight radical surgeries were evaluated: 3 Gross type-A, 1 type-B, 30 type-C, 1 type-D, and 3 type-E. The cervical approach was performed in 5 cases and thoracoscopic esophageal anastomosis in 33, including 26 single-stage (all type-C) and 7 multistage surgeries (3 type-A, 3 type-C, and 1 type-D). There were no cases of thoracotomies or intraoperative thoracoscopic surgery complications. Three cases of minor leakage were conservatively resolved. Three postoperative chylothorax surgeries (9%) and seven balloon dilatations (21%) for anastomotic stenosis were performed. Conclusion: Thoracoscopic radical surgery for treating EA, including single- and multistage procedures, can be performed, except in type-E cases or when the end of the proximal esophagus is located higher than the clavicle.

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  135. Investigation of the feasibility and safety of single-stage anorectoplasty in neonates with anovestibular fistula Reviewed Open Access

    Shirota, C; Suzuki, K; Uchida, H; Kawashima, H; Hinoki, A; Tainaka, T; Sumida, W; Murase, N; Oshima, K; Chiba, K; Makita, S; Tanaka, Y

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 34 ( 10 ) page： 1117 - 1120   2018.10

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    Purpose: Anovestibular fistula (AVF) is the most common type of anorectal malformation in females. Delayed anorectoplasty with fistula dilatation is commonly performed during infancy; however, we have been actively performing anorectoplasty in neonates. We report the surgical complications and postoperative defecation function associated with single-stage anorectoplasty performed in neonates. Methods: Patients who underwent surgery for AVF between 2007 and 2017 at two institutions were retrospectively studied. The operation time, amount of bleeding, time to start oral intake, perioperative complications, and Kelly’s score were compared among patients who underwent surgery as neonates and those who underwent surgery as infants. Results: Eighteen neonates and 17 infants underwent anterior sagittal anorectoplasty. The median operation time and time to start oral intake were significantly shorter in the neonatal group (72 min; 3 days, respectively) than in the infant group (110 min, p = 0.0002; 5 days, p = 0.0024, respectively). Postoperative wound disruption was significantly more frequent in the infant group. Of the ten patients each in the neonatal and infant groups, there was no significant difference in Kelly’s score at age ≥ 4 years. Conclusion: Single-stage anorectoplasty in neonates with AVF can be feasibly performed and does not impair postoperative defecation function. Levels of evidence: III.

    DOI： 10.1007/s00383-018-4324-3

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  136. Long-term outcomes and complications after laparoscopic-assisted anorectoplasty vs. posterior sagittal anorectoplasty for high- and intermediate-type anorectal malformation Reviewed

    Tainaka, T; Uchida, H; Tanaka, Y; Hinoki, A; Shirota, C; Sumida, W; Yokota, K; Makita, S; Oshima, K; Chiba, K; Ishimaru, T; Kawashima, H

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 34 ( 10 ) page： 1111 - 1115   2018.10

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    Language：English   Publisher：Pediatric Surgery International  

    Purpose: Laparoscopic-assisted anorectoplasty (LAARP) is a minimally invasive procedure in which the levator ani muscle is left to potentially improve postoperative fecal continence. This study aimed to retrospectively evaluate postoperative complications and long-term outcomes of fecal continence after LAARP and compare them to those after posterior sagittal anorectoplasty (PSARP). Methods: Forty-five male patients with high and intermediate anorectal malformation (aged ≥ 4 years) who underwent LAARP or PSARP (LAARP 29, PSARP 16) from 1999 to 2013 were included. Postoperative complications and postoperative fecal continence were retrospectively evaluated and compared. Postoperative complications were also compared before and after introducing a urethroscope during fistula resection. Results: Complications after LAARP and PSARP were seen in 12 vs. 2 cases (p = 0.09) of mucosal prolapse and in 9 vs. 1 case (p = 0.07) of posterior urethral diverticulum (PUD), respectively. The incidence of PUD decreased after introduction of a urethroscopy from 40% in 8/20 cases to 11% in 1/9 cases. No significant difference was found in terms of fecal continence in both groups. Conclusion: Through our study, greater improvement of postoperative fecal continence after LAARP has not been shown. LAARP was at higher risk for mucosal prolapse and PUD. However, precise dissection of the urethral fistula could be performed after the introduction of urethroscopy.

    DOI： 10.1007/s00383-018-4323-4

    Web of Science

    Scopus

    PubMed

  137. Risk factors for thoracic and spinal deformities following lung resection in neonates, infants, and children Reviewed Open Access

    Makita, S; Kaneko, K; Ono, Y; Uchida, H

    SURGERY TODAY   Vol. 47 ( 7 ) page： 810 - 814   2017.7

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    Language：English   Publisher：Surgery Today  

    Purpose: We aimed to identify the risk factors for thoracic and spinal deformities following lung resection during childhood and to elucidate whether thoracoscopic surgery reduces the risk of complications after lung resection. Methods: We retrospectively examined the medical records of all pediatric patients who underwent lung resection for congenital lung disease at our institution between 1989 and 2014. Results: Seventy-four patients underwent lung resection during the study period and were followed-up. The median age of the patients at the time of surgery was 5 months (range 1 day–13 years), and 22 were neonates. Thoracotomy and thoracoscopy were performed in 25 and 49 patients, respectively. Thoracic or spinal deformities occurred in 28 of the 74 patients (37%). Univariate analyses identified thoracotomy, being a neonate (age: <1 month) at the time of surgery, and being symptomatic at the time of surgery as risk factors for these deformities. However, a multivariate analysis indicated that only thoracotomy and being a neonate were risk factors for deformities. Conclusions: Thoracoscopic surgery reduced the risk of thoracic and spinal deformities following lung resection in children. We suggest that, where possible, lung resection should be avoided until 2 or 3 months of age.

    DOI： 10.1007/s00595-016-1434-1

    Open Access

    Web of Science

    Scopus

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KAKENHI (Grants-in-Aid for Scientific Research) 12

  1. 網羅的遺伝子解析による胆道閉鎖症の病態解明と新たな治療薬の開発

    Grant number：25K11860  2025.4 - 2028.3

    科学研究費助成事業  基盤研究(C)

    田井中 貴久, 城田 千代栄, 牧田 智, 内田 広夫, 天野 日出, 中川 洋一, 檜 顕成

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    Authorship：Coinvestigator(s) 

    胆道閉鎖症は胆汁鬱滞を引き起こす一つの症候群であり、多因子要因であると推定されている。従来の研究ではいくつか関連が示唆される遺伝子変異が特定されているが、本邦におけるデータを乏しい。胆道閉鎖症の発症機序は人種、地域により異なることが考えられるため、本邦の遺伝的要因・エピジェネティクスの解明は必須である。本研究では、特定の遺伝子変異を特定して、これに基づく診断法および治療法の開発を進めること、およびエピジェネティクス（遺伝子発現変化）に着目して、発症病態の解明と新規治療薬の開発を進める。

  2. Challenge of Developing an AI-Based CT Image Analysis Algorithm for the Diagnosis of Intestinal Necrosis/Intestinal Perforation

    Grant number：24K22377  2024.6 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

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    Authorship：Coinvestigator(s) 

  3. Development of a real-time surgical skill evaluation system by using machine learning and AI image analysis for pediatric surgery improvement

    Grant number：24K15206  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship：Coinvestigator(s) 

  4. 新規神経芽腫マーカー（CTN/VLA）の有効性（診断率・悪性度予測）検証と病態解明

    Grant number：24K11018  2024.4 - 2027.3

    科学研究費助成事業  基盤研究(C)

    檜 顕成, 内田 広夫, 高橋 義行, 成田 敦, 大澤 毅, 城田 千代栄, 田井中 貴久, 天野 日出, 牧田 智, 横田 一樹

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    Authorship：Coinvestigator(s) 

    CTN/VLAは既存マーカーと比較し悪性度を予測できる点で臨床的に有効なマーカーになり得る可能性があり、世界的にもCTNとMYC変異との強い相関が注目されつつある。特に最近の研究においてCTNについては、腫瘍細胞フェロトーシスと脂質過酸化（CTN蓄積）、MYC変異との関与から、神経芽腫の自然退縮（細胞死）との関連が示唆され、フェロトーシスの調節が神経芽腫の将来の治療に繋がると考えられている。
    本研究ではMYC遺伝子増幅神経芽腫サンプル/非増幅サンプル/健常コントロールサンプルにおいてCTN/VLAの有効性（診断率・腫瘍悪性度予測）の検証を行う。
    神経芽腫の早期発見と速やかな治療を目的に、カテコラミン代謝産物であるHVA/VMAによる神経芽腫マススクリーニングが以前行われていた。しかしながらカテコラミン非産生神経芽腫などの悪性度の高い神経芽腫を発見できなかったこと、低リスク症例への過剰な手術侵襲や術後合併症が生じたことなどが一因でマススクリーニングは中止となった。そこで既存マーカーの弱点を克服する①カテコラミン非産生神経芽腫を含めた約10%程度の偽陰性症例の取りこぼしを防ぎ、②治療を優先すべき悪性度の高い神経芽腫を判別するマーカーの開発が望まれてきた。申請者らはこれまでに新規マーカー候補であるVanillactate（VLA：カテコラミン代謝物）は高リスク症例との相関が高く、Cystathionine（CTN：非カテコラミン代謝物）は非カテコラミン神経芽腫の診断に有効で更に悪性度の高い変異と強く相関することを明らかにし、CTN/VLAによりカテコラミン陰性の悪性度の高い神経芽腫をとりこぼしなく診断できる可能性を示した。本研究ではCTN/VLAの有効性を検証する。令和6年度はCTN/VLAの測定法を構築し、精度検証のために前向きに神経芽腫患者と健常コントロールの尿検体を収集中である。
    当初の計画通り、令和6年度はCTN/VLAの測定法を構築し、精度検証のために前向きに神経芽腫患者と健常コントロールの尿検体を収集中である。
    今後は神経芽腫患者と健常コントロールの尿検体を収集し、CTN/VLAの精度を前向きに検証し、神経芽腫の新規マーカーとして実用化を目指す。

  5. Improvement and Validation of a Discriminant Model for Amplification of the Neuroblastoma MYC Gene by Tyrosine Metabolite Markers

    Grant number：23K07308  2023.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship：Principal investigator 

    Grant amount：\4810000 （ Direct Cost: \3700000 、 Indirect Cost：\1110000 ）

  6. Development of surgical navigation system for esophageal atresia / tracheoesophageal fistula using AI Image analysis and forceps location information

    Grant number：22H03703  2022.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship：Coinvestigator(s) 

  7. Metabolomic Analysis in Rhabdomyosarcoma (Urine/Tissue) for the Identification of Diagnostic Markers and Oncometabolites

    Grant number：22K07911  2022.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Wataru Sumida

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    Authorship：Coinvestigator(s) 

    Rhabdomyosarcoma is the most common soft tissue tumor in children, and the development of new diagnostic and therapeutic methods is needed. Recently, advances in metabolomics with a mass spectrometry have made it possible to robustly acquire metabolic profiles. Elucidating metabolic alterations in rhabdomyosarcoma will contribute to developing new biomarkers. This study aimed to develop novel tumor markers for rhabdomyosarcoma. Urinary metabolites from patients with rhabdomyosarcoma and healthy individuals were measured via mass spectrometry, and three metabolites with high discriminative power for rhabdomyosarcoma were identified. The combination of these three metabolites demonstrated the robust ability in predicting and distinguishing between healthy individuals and patients with rhabdomyosarcoma.

  8. 腎芽腫メタボローム解析（尿/組織）による診断マーカーとオンコメタボライト探索

    Grant number：22K07276  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    岡本 眞宗, 城田 千代栄, 成田 敦, 牧田 智, 田井中 貴久, 内田 広夫, 高橋 義行, 大澤 毅, 住田 亙, 田中 裕次郎, 檜 顕成

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    Authorship：Coinvestigator(s) 

    増殖・浸潤・転移などがんの進展における中心代謝と代謝リプログラミングの役割については未だ不明な点が多い。本研究で腎芽腫細胞に特異的な中心代謝に関与する代謝物（オンコメタボライト）を見出す。がん細胞に特異的な代謝系を見出すことにより、正常細胞の代謝系との違いを標的とする新たながんの治療戦略の開発を目指す。腎芽腫患児の尿、腫瘍組織のキャピラリー電気泳動質量分析法を中心とした代謝物解析により、中心代謝に関与するオンコメタボライトを探索し、従来の集学的治療と遺伝子解析だけでは解明できなかった病態解明及び新たな診断治療法の開発に繋げる。
    Wilms腫瘍には特異的なバイオマーカーがない。発症早期に自覚症状は乏しく、血尿で早期発見されるよりも、腹部膨満や腹部腫瘤として進行した段階で発見されることが多い。早期発見に繋がるWilms腫瘍のバイオマーカーの開発は社会的意義が高く喫緊の課題となっている。我々はメタボロミクスアプローチに着目し、Wilms腫瘍患児の尿、組織、に由来する生体サンプルに含まれる代謝物を網羅的に解析しバイオマーカー候補を探索した。本研究では特にWilms腫瘍患児の術前・術後の尿の代謝物を分析し、Wilms腫瘍患児で変動する代謝物を探索した。治療前後でWilms腫瘍患児の尿検体を中心に臨床情報を含めて回収した。回収した尿検体は-80℃に凍結保存して保管し、解析に際しては解凍して一部を質量分析計にて代謝物解析した。Wilms腫瘍患児の尿サンプルは腫瘍切除前後で収集した。また、本研究ではできるだけ多くのバイオマーカー候補となり得る代謝物を抽出する為に、液体クロマトグラム質量分析計（LC/MS:　Liquid Chromatograph/Mass Spectrometer）だけでなく、イオン性代謝物を測定できる分析法（CE/MS：Capillary Electrophoresis/Mass Spectrometer）も採用し、がん細胞と正常細胞に存在する低分子代謝物を測定しWilms腫瘍症例に疾患貢献度の高い尿中代謝物を探索した。本研究においてWilms腫瘍患児尿に関してはLC/MSで39サンプル、CE/MSで10サンプルの解析を行い、バイオマーカー候補を検討した。

  9. Development of a Surgical Navigation System for Esophageal Atresia Using AI-Based Image Analysis and Forceps Position Tracking

    Grant number：23K24958  2022.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Uchida Hiroo

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    Authorship：Coinvestigator(s) 

    This study aimed to develop an AI-assisted intraoperative navigation and automated surgical skill assessment system for thoracoscopic repair of esophageal atresia, to support surgical safety and education. An AI model was trained to recognize the vagus nerve, a critical structure to avoid during surgery. Evaluation by 54 pediatric surgeons showed the AI identified anatomy significantly faster than novices (p<0.001) and performed comparably to experts (p=0.159). A real-time skill assessment model was also developed using suturing videos, evaluating smoothness, efficiency, and coordination. The model accurately classified lower- and higher-skill groups (95% and 88%, respectively), showing promise as a training tool.

  10. Development of fluorescent probes for diagnosis and treatment of pediatric surgical diseases

    Grant number：21K08640  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    SHIROTA CHIYOE

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    Authorship：Coinvestigator(s) 

    In this study, experiments were conducted to identify distant micro-metastases in pediatric cancer rapidly and easily during operation and detect abnormal intestine of Hirschsprung’s disease, which is one of congenital pediatric diseases other than pediatric cancer visually. Measuring peptidase activity in Hirschsprung’s disease intestine showed that multiple peptidase activity in normal intestine was 2.5 times higher than that in abnormal intestine, but also showed that peptidase activity in normal intestine varied much each sample. While identifying common background factors of novel samples, developing fluorescent probe against these specific enzymes and differentiating normal and abnormal intestine visually is being investigated.

  11. Research on peptide-based material surface design for tissue regeneration

    Grant number：21K16379  2021.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    Makita Satoshi

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    Authorship：Principal investigator 

    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

    In this study, we screened novel candidate peptides that inhibit fibrosis and promote tissue regeneration and constructed an in vitro/in vivo model to evaluate fibrosis inhibitory performance of functional peptides.
    Specifically, we screened myofibroblast differentiation inhibitory trimer peptides using peptide-modified arrays of 20 simple sequences of trimer amino acids, suggesting the possibility that myofibroblast differentiation can be regulated by various peptide-modified surfaces.

  12. Refractory pediatric lung cancer treatment with photothermal therapy using DDS-type light-absorbing supramolecules cancer treatment

    Grant number：19K20708  2019.4 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    Makita Satoshi

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    Authorship：Principal investigator 

    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

    The applicant has already established a mouse model of orthotopic pathology of retroperitoneal invasion using neuroblastoma cells with a luminescence gene, and has confirmed that fluorescence imaging by ICG lactosome and photothermal irradiation by near-infrared light can induce tumor regression. While confirming the induction of tumor shrinkage by fluorescence imaging and near-infrared photothermal irradiation using ICG lactosomes in a neuroblastoma model, we aimed to establish an osteosarcoma lung metastasis model.
    ICGm was selectively accumulated in the tumor; it was shown that ICGm accumulated most in the tumor at 72 hours after administration and migrated to the tumor membrane on the fourth day, where it was gradually excreted.

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To the head of KAKENHI (Grants-in-Aid for Scientific Research).▲