Updated on 2022/03/16

写真a

 
MATSUI Shigeyuki
 
Organization
Graduate School of Medicine Program in Integrated Medicine Clinical Pharmacology Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine
Title
Professor
Contact information
メールアドレス
External link

Degree 1

  1. Ph.D. ( 1999.3   Tokyo University of Science ) 

Research Areas 1

  1. Others / Others  / Biostatistics

Awards 1

  1. 日本計量生物学会 2014年学会賞

    2014.5   日本計量生物学会  

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    Country:Japan

 

Papers 161

  1. Risk factors for antibiotic resistance in hospital-acquired and ventilator-associated pneumonia.

    Sano M, Shindo Y, Takahashi K, Okumura J, Sakakibara T, Murakami Y, Iguchi M, Yagi T, Matsui S, Hasegawa Y

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy     2022.2

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    Language:English  

    DOI: 10.1016/j.jiac.2022.02.012

    PubMed

  2. A prediction rule for severe adverse events in all inpatients with community-acquired pneumonia: a multicenter observational study

    Sakakibara Toshihiro, Shindo Yuichiro, Kobayashi Daisuke, Sano Masahiro, Okumura Junya, Murakami Yasushi, Takahashi Kunihiko, Matsui Shigeyuki, Yagi Tetsuya, Saka Hideo, Hasegawa Yoshinori

    BMC PULMONARY MEDICINE   Vol. 22 ( 1 ) page: 34   2022.1

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  3. Clinical paper The rCAST score is useful for estimating the neurological prognosis in pediatric patients with post-cardiac arrest syndrome before ICU admission: External validation study using a nationwide prospective registry

    Yasuda Yuma, Nishikimi Mitsuaki, Matsui Kota, Numaguchi Atsushi, Nishida Kazuki, Emoto Ryo, Matsui Shigeyuki, Matsuda Naoyuki

    RESUSCITATION   Vol. 168   page: 103 - 109   2021.11

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  4. Hypofibrinogenemia can be estimated by the predictive formula in aortic surgery

    Nishi Toshihiko, Mutsuga Masato, Akita Toshiaki, Narita Yuji, Fujimoto Kazuro, Tokuda Yoshiyuki, Nishida Kazuki, Matsui Shigeyuki, Nishiwaki Kimitoshi, Usui Akihiko

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   Vol. 69 ( 10 ) page: 1376 - 1382   2021.10

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  5. Postoperative stroke and neurological outcomes in the early phase after revascularization surgeries for moyamoya disease: an age-stratified comparative analysis

    Araki Yoshio, Yokoyama Kinya, Uda Kenji, Kanamori Fumiaki, Kurimoto Michihiro, Shiba Yoshiki, Mamiya Takashi, Nishihori Masahiro, Izumi Takashi, Sumitomo Masaki, Okamoto Sho, Matsui Kota, Emoto Ryo, Wakabayashi Toshihiko, Matsui Shigeyuki, Natsume Atsushi

    NEUROSURGICAL REVIEW   Vol. 44 ( 5 ) page: 2785 - 2795   2021.10

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  6. Clinical impact of visually assessed right ventricular dysfunction in patients with septic shock

    Hiraiwa Hiroaki, Kasugai Daisuke, Ozaki Masayuki, Goto Yukari, Jingushi Naruhiro, Higashi Michiko, Nishida Kazuki, Kondo Toru, Furusawa Kenji, Morimoto Ryota, Okumura Takahiro, Matsuda Naoyuki, Matsui Shigeyuki, Murohara Toyoaki

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 18823   2021.9

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  7. Outcome Related to Level of Targeted Temperature Management in Postcardiac Arrest Syndrome of Low, Moderate, and High Severities: A Nationwide Multicenter Prospective Registry

    Nishikimi Mitsuaki, Ogura Takayuki, Nishida Kazuki, Hayashida Kei, Emoto Ryo, Matsui Shigeyuki, Matsuda Naoyuki, Iwami Taku

    CRITICAL CARE MEDICINE   Vol. 49 ( 8 ) page: E741 - E750   2021.8

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  8. A large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer

    Yoshihara Masato, Emoto Ryo, Kitami Kazuhisa, Iyoshi Shohei, Uno Kaname, Mogi Kazumasa, Tano Sho, Yoshikawa Nobuhisa, Matsui Shigeyuki, Kajiyama Hiroaki

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 15154   2021.7

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  9. Relative platelet reductions provide better pathophysiologic signatures of coagulopathies in sepsis

    Kasugai Daisuke, Ozaki Masayuki, Nishida Kazuki, Goto Yukari, Takahashi Kunihiko, Matsui Shigeyuki, Matsuda Naoyuki

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 14033   2021.7

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  10. The interplay between bystander cardiopulmonary resuscitation and ambient temperature on neurological outcome after cardiac arrest: A nationwide observational cohort study

    Hayashida Kei, Takegawa Ryosuke, Nishikimi Mitsuaki, Aoki Tomoaki, Emoto Ryo, Shinozaki Koichiro, Miyara Santiago J., Rolston Daniel M., Li Timmy, Shoaib Muhammad, Fukuda Tatsuma, Molmenti Ernesto P., Suzuki Masaru, Sasaki Junichi, Matsui Shigeyuki, Becker Lance B.

    RESUSCITATION   Vol. 164   page: 46 - 53   2021.7

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  11. Statistical Models in Clinical Studies

    Matsui Shigeyuki, Le-Rademacher Jennifer, Mandrekar Sumithra J.

    JOURNAL OF THORACIC ONCOLOGY   Vol. 16 ( 5 ) page: 734 - 739   2021.5

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  12. Semi-parametric empirical Bayes factor for genome-wide association studies

    Morisawa Junji, Otani Takahiro, Nishino Jo, Emoto Ryo, Takahashi Kunihiko, Matsui Shigeyuki

    EUROPEAN JOURNAL OF HUMAN GENETICS   Vol. 29 ( 5 ) page: 800 - 807   2021.5

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  13. Failure of non-invasive respiratory support after 6 hours from initiation is associated with ICU mortality

    Nishikimi Mitsuaki, Nishida Kazuki, Shindo Yuichiro, Shoaib Muhammad, Kasugai Daisuke, Yasuda Yuma, Higashi Michiko, Numaguchi Atsushi, Yamamoto Takanori, Matsui Shigeyuki, Matsuda Naoyuki

    PLOS ONE   Vol. 16 ( 4 ) page: e0251030   2021.4

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  14. Blinded Sample Size Re-Estimation in Comparative Clinical Trials With Overdispersed Count Data: Incorporation of Misspecification of the Variance Function

    Igeta Masataka, Matsui Shigeyuki

    STATISTICS IN BIOPHARMACEUTICAL RESEARCH   Vol. 13 ( 2 ) page: 170 - 180   2021.4

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  15. Prognostic value of desmoplastic reaction characterisation in stage II colon cancer: prospective validation in a Phase 3 study (SACURA Trial)

    Ueno Hideki, Ishiguro Megumi, Nakatani Eiji, Ishikawa Toshiaki, Uetake Hiroyuki, Murotani Kenta, Matsui Shigeyuki, Teramukai Satoshi, Sugai Tamotsu, Ajioka Yoichi, Maruo Hirotoshi, Kotaka Masahito, Tsujie Masaki, Munemoto Yoshinori, Yamaguchi Takashi, Kuroda Hisashi, Fukunaga Mutsumi, Tomita Naohiro, Sugihara Kenichi

    BRITISH JOURNAL OF CANCER   Vol. 124 ( 6 ) page: 1088 - 1097   2021.3

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  16. Does complete-staging lymphadenectomy improve survival outcomes in stage I endometrioid epithelial ovarian carcinoma? A multi-institutional retrospective study with propensity score-weighted analysis

    Yoshihara Masato, Tamauchi Satoshi, Iyoshi Shohei, Kitami Kazuhisa, Uno Kaname, Tano Sho, Matsui Shigeyuki, Kajiyama Hiroaki

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 51 ( 3 ) page: 387 - 392   2021.3

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  17. Effect-Size Estimation Using Semiparametric Hierarchical Mixture Models in Disease-Association Studies with Neuroimaging Data

    Emoto Ryo, Kawaguchi Atsushi, Takahashi Kunihiko, Matsui Shigeyuki

    COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE   Vol. 2020   page: 7482403   2020.12

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  18. Optimal Criteria for G3 (Poorly Differentiated) Stage II Colon Cancer Prospective Validation in a Randomized Controlled Study (SACURA Trial)

    Ueno Hideki, Ishiguro Megumi, Nakatani Eiji, Ishikawa Toshiaki, Uetake Hiroyuki, Matsui Shigeyuki, Teramukai Satoshi, Murotani Kenta, Ajioka Yoichi, Shimazaki Hideyuki, Maeda Atsuyuki, Takuma Kunio, Yoshida Takefumi, Kambara Takeshi, Matsuda Keiji, Takagane Akinori, Tomita Naohiro, Sugihara Kenichi

    AMERICAN JOURNAL OF SURGICAL PATHOLOGY   Vol. 44 ( 12 ) page: 1685 - 1698   2020.12

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  19. Relationship Between Bone Mineral Density and Risk of Vertebral Fractures with Denosumab Treatment in Japanese Postmenopausal Women and Men with Osteoporosis

    Okubo Naoki, Matsui Shigeyuki, Matsumoto Toshio, Sugimoto Toshitsugu, Hosoi Takayuki, Osakabe Taisuke, Watanabe Ko, Takami Hideo, Shiraki Masataka, Nakamura Toshitaka

    CALCIFIED TISSUE INTERNATIONAL   Vol. 107 ( 6 ) page: 559 - 566   2020.12

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  20. Desmoid with biweekly methotrexate and vinblastine shows similar effects to weekly administration: A phase II clinical trial

    Nishida Yoshihiro, Hamada Shunsuke, Urakawa Hiroshi, Ikuta Kunihiro, Sakai Tomohisa, Koike Hiroshi, Ito Kan, Emoto Ryo, Ando Yuichi, Matsui Shigeyuki

    CANCER SCIENCE   Vol. 111 ( 11 ) page: 4187 - 4194   2020.11

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  21. The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies

    Kumagai Shogo, Togashi Yosuke, Kamada Takahiro, Sugiyama Eri, Nishinakamura Hitomi, Takeuchi Yoshiko, Vitaly Kochin, Itahashi Kota, Maeda Yuka, Matsui Shigeyuki, Shibahara Takuma, Yamashita Yasuho, Irie Takuma, Tsuge Ayaka, Fukuoka Shota, Kawazoe Akihito, Udagawa Hibiki, Kirita Keisuke, Aokage Keiju, Ishii Genichiro, Kuwata Takeshi, Nakama Kenta, Kawazu Masahito, Ueno Toshihide, Yamazaki Naoya, Goto Koichi, Tsuboi Masahiro, Mano Hiroyuki, Doi Toshihiko, Shitara Kohei, Nishikawa Hiroyoshi

    NATURE IMMUNOLOGY   Vol. 21 ( 11 ) page: 1346 - +   2020.11

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  22. Maximum Norepinephrine Dosage Within 24 Hours as an Indicator of Refractory Septic Shock: A Retrospective Study

    Kasugai Daisuke, Hirakawa Akihiko, Ozaki Masuyuki, Nishida Kazuki, Ikeda Takao, Takahashi Kunihiko, Matsui Shigeyuki, Uenishi Norimichi

    JOURNAL OF INTENSIVE CARE MEDICINE   Vol. 35 ( 11 ) page: 1285 - 1289   2020.11

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  23. Impact of uterus-preserving surgery on Stage I primary mucinous epithelial ovarian carcinoma: A multi-institutional study with propensity score-weighted analysis

    Yoshihara Masato, Kajiyama Hiroaki, Tamauchi Satoshi, Iyoshi Shohei, Yokoi Akira, Suzuki Shiro, Kawai Michiyasu, Nagasaka Tetsuro, Takahashi Kunihiko, Matsui Shigeyuki, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS   Vol. 150 ( 2 ) page: 177 - 183   2020.8

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  24. High-flow nasal cannula therapy for acute respiratory failure in patients with interstitial pneumonia: a retrospective observational study.

    Omote N, Matsuda N, Hashimoto N, Nishida K, Sakamoto K, Ando A, Nakahara Y, Nishikimi M, Higashi M, Matsui S, Hasegawa Y

    Nagoya journal of medical science   Vol. 82 ( 2 ) page: 301 - 313   2020.5

  25. Relationship Between Serum Norepinephrine Levels at ICU Admission and the Risk of ICU-Acquired Delirium: Secondary Analysis of the Melatonin Evaluation of Lowered Inflammation of ICU Trial.

    Yasuda Y, Nishikimi M, Nishida K, Takahashi K, Numaguchi A, Higashi M, Matsui S, Matsuda N

    Critical care explorations   Vol. 2 ( 2 ) page: e0082   2020.2

  26. A single paravertebral injection via a needle vs. a catheter for the spreading to multiple intercostal levels: a randomized controlled trial

    Fujii Tasuku, Shibata Yasuyuki, Ban Yasutaka, Shitaokoshi Akira, Takahashi Kunihiko, Matsui Shigeyuki, Nishiwaki Kimitoshi

    JOURNAL OF ANESTHESIA   Vol. 34 ( 1 ) page: 72 - 78   2020.2

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  27. Prognostic impact of pelvic and para-aortic lymphadenectomy on clinically-apparent stage I primary mucinous epithelial ovarian carcinoma: a multi-institutional study with propensity score-weighted analysis

    Yoshihara Masato, Kajiyama Hiroaki, Tamauchi Satoshi, Iyoshi Shohei, Yokoi Akira, Suzuki Shiro, Kawai Michiyasu, Nagasaka Tetsuro, Takahashi Kunihiko, Matsui Shigeyuki, Kikkawa Fumitaka

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 50 ( 2 ) page: 145 - 151   2020.2

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  28. More Powerful Selective Kernel Tests for Feature Selection

    Lim Jen Ning, Yamada Makoto, Jitkrittum Wittawat, Terada Yoshikazu, Matsui Shigeyuki, Shimodaira Hidetoshi

    INTERNATIONAL CONFERENCE ON ARTIFICIAL INTELLIGENCE AND STATISTICS, VOL 108   Vol. 108   page: 820 - 829   2020

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  29. Diagnosis of central diabetes insipidus using a vasopressin radioimmunoassay during hypertonic saline infusion

    Takagi Hiroshi, Hagiwara Daisuke, Handa Tomoko, Sugiyama Mariko, Onoue Takeshi, Tsunekawa Taku, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Suga Hidetaka, Banno Ryoichi, Takahashi Kunihiko, Matsui Shigeyuki, Arima Hiroshi

    ENDOCRINE JOURNAL   Vol. 67 ( 3 ) page: 267 - 274   2020

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  30. A randomised controlled trial of pectoral nerve-2 (PECS 2) block vs. serratus plane block for chronic pain after mastectomy. Reviewed

    Fujii T, Shibata Y, Akane A, Aoki W, Sekiguchi A, Takahashi K, Matsui S, Nishiwaki K

    Anaesthesia   Vol. 74 ( 12 ) page: 1558 - 1562   2019.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/anae.14856

    Web of Science

  31. Clinical Frailty Scale Score Before ICU Admission Is Associated With Mobility Disability in Septic Patients Receiving Early Rehabilitation.

    Nakajima H, Nishikimi M, Shimizu M, Hayashi K, Inoue T, Nishida K, Takahashi K, Matsui S, Nishida Y, Matsuda N

    Critical care explorations   Vol. 1 ( 12 ) page: e0066   2019.12

  32. Prognostic factors and effects of fertility-sparing surgery in women of reproductive age with ovarian clear-cell carcinoma: a propensity score analysis. Reviewed

    Yoshihara M, Kajiyama H, Tamauchi S, Suzuki S, Takahashi K, Matsui S, Kikkawa F

    J Gynecol Oncol   Vol. 30 ( 6 ) page: e102   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3802/jgo.2019.30.e102.

  33. Prognostic factors and effects of fertility-sparing surgery in women of reproductive age with ovarian clear-cell carcinoma: a propensity score analysis

    Yoshihara Masato, Kajiyama Hiroaki, Tamauchi Satoshi, Suzuki Shiro, Takahashi Kunihiko, Matsui Shigeyuki, Kikkawa Fumitaka

    JOURNAL OF GYNECOLOGIC ONCOLOGY   Vol. 30 ( 6 ) page: e102   2019.11

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  34. Prospective Multicenter Study on the Prognostic and Predictive Impact of Tumor Budding in Stage II Colon Cancer: Results From the SACURA Trial. Reviewed

    Ueno H, Ishiguro M, Nakatani E, Ishikawa T, Uetake H, Matsuda C, Nakamoto Y, Kotake M, Kurachi K, Egawa T, Yasumasa K, Murata K, Ikawa O, Shinji S, Murotani K, Matsui S, Teramukai S, Tomita N, Sugihara K

    J Clin Oncol   Vol. 37 ( 22 ) page: 1886-1894   2019.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1200/JCO.18.02059.

  35. Prospective Multicenter Study on the Prognostic and Predictive Impact of Tumor Budding in Stage II Colon Cancer: Results From the SACURA Trial

    Ueno Hideki, Ishiguro Megumi, Nakatani Eiji, Ishikawa Toshiaki, Uetake Hiroyuki, Matsuda Chu, Nakamoto Yoshihiko, Kotake Masanori, Kurachi Kiyotaka, Egawa Tomohisa, Yasumasa Keigo, Murata Kohei, Ikawa Osamu, Shinji Seiichi, Murotani Kenta, Matsui Shigeyuki, Teramukai Satoshi, Tomita Naohiro, Sugihara Kenichi

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 37 ( 22 ) page: 1886 - +   2019.8

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  36. Two-stage analysis for selecting fixed numbers of features in omics association studies. Reviewed

    Kawabata T, Emoto R, Nishino J, Takahashi K, Matsui S

    Stat Med   Vol. 38 ( 16 ) page: 2956-2971   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/sim.8150.

  37. Two-stage analysis for selecting fixed numbers of features in omics association studies

    Kawabata Takanori, Emoto Ryo, Nishino Jo, Takahashi Kunihiko, Matsui Shigeyuki

    STATISTICS IN MEDICINE   Vol. 38 ( 16 ) page: 2956 - 2971   2019.7

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    Language:Japanese  

    DOI: 10.1002/sim.8150

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  38. Steeper Macular Curvature in Eyes With Non-Highly Myopic Retinitis Pigmentosa. Reviewed

    Komori S, Ueno S, Ito Y, Sayo A, Meinert M, Kominami T, Inooka D, Kitagawa M, Nishida K, Takahashi K, Matsui S, Terasaki H

    Invest Ophthalmol Vis Sci   Vol. 60 ( 8 ) page: 3135-3141   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1167/iovs.19-27334.

  39. Statistical testing strategies for assessing treatment efficacy and marker accuracy in phase III trials Reviewed

    Nonaka T, Igeta M, Matsui S

    Pharm Stat   Vol. 18 ( 4 ) page: 459-475   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/pst.1937.

  40. External validation of a risk classification at the emergency department of post-cardiac arrest syndrome patients undergoing targeted temperature management. Reviewed

    Nishikimi M, Ogura T, Nishida K, Takahashi K, Nakamura M, Matsui S, Matsuda N, Iwami T

    Resuscitation   ( 140 ) page: 135-141   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.resuscitation.2019.05.028.

  41. Steeper Macular Curvature in Eyes With Non-Highly Myopic Retinitis Pigmentosa

    Komori Shiori, Ueno Shinji, Ito Yasuki, Sayo Akira, Meinert Monika, Kominami Taro, Inooka Daiki, Kitagawa Masahiro, Nishida Kazuki, Takahashi Kunihiko, Matsui Shigeyuki, Terasaki Hiroko

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   Vol. 60 ( 8 ) page: 3135 - 3141   2019.7

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  42. Statistical testing strategies for assessing treatment efficacy and marker accuracy in phase III trials

    Nonaka Takahiro, Igeta Masataka, Matsui Shigeyuki

    PHARMACEUTICAL STATISTICS   Vol. 18 ( 4 ) page: 459 - 475   2019.7

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    Language:Japanese  

    DOI: 10.1002/pst.1937

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  43. Novel multi-gene classifier for prediction of relapse-free survival after FU-based adjuvant chemotherapy for stage III colon cancer: A biomarker study of the ACTS-C trial, a randomized controlled study

    Ishikawa Toshiaki, Murotani Kenta, Ishiguro Megumi, Nakatani Eiji, Uetake Hiroyuki, Matsui Shigeyuki, Sugihara Kenichi

    CANCER RESEARCH   Vol. 79 ( 13 )   2019.7

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  44. External validation of a risk classification at the emergency department of post-cardiac arrest syndrome patients undergoing targeted temperature management

    Nishikimi Mitsuaki, Ogura Takayuki, Nishida Kazuki, Takahashi Kunihiko, Nakamura Mitsunobu, Matsui Shigeyuki, Matsuda Naoyuki, Iwami Taku

    RESUSCITATION   Vol. 140   page: 135 - 141   2019.7

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  45. Maximum norepinephrine dosage within 24 hours as an indicator of refractory septic shock: A retrospective study.

    Kasugai D, Hirakawa A, Ozaki M, Nishida K, Ikeda T, Takahashi K, Matsui S, Uenishi N

    J Intensive Care Med     page: 885066619860736   2019.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/0885066619860736.

  46. Timing of administration of epinephrine predicts the responsiveness to epinephrine in norepinephrine-refractory septic shock: a retrospective study. Reviewed

    Kasugai D, Nishikimi M, Nishida K, Higashi M, Yamamoto T, Numaguchi A, Takahashi K, Matsui S, Matsuda N

    J Intensive Care   Vol. 7   page: 20   2019.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40560-019-0377-1.

  47. Timing of administration of epinephrine predicts the responsiveness to epinephrine in norepinephrine-refractory septic shock: a retrospective study

    Kasugai Daisuke, Nishikimi Mitsuaki, Nishida Kazuki, Higashi Michiko, Yamamoto Takanori, Numaguchi Atsushi, Takahashi Kunihiko, Matsui Shigeyuki, Matsuda Naoyuki

    JOURNAL OF INTENSIVE CARE   Vol. 7   page: 20   2019.4

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  48. Hokuriku Liver Study Group. Development of novel diagnostic system for pancreatic cancer, including early stages, measuring mRNA of whole blood cells. Reviewed

    Sakai Y, Honda M, Matsui S, Komori O, Murayama T, Fujiwara T, Mizuno M, Imai Y, Yoshimura K, Nasti A, Wada T, Iida N, Kitahara M, Horii R, Toshikatsu T, Nishikawa M, Okafuji H, Mizukoshi E, Yamashita T, Yamashita T, Arai K, Kitamura K, Kawaguchi K, Takatori H, Shimakami T, Terashima T, Hayashi T, Nio K, Kaneko S

    Cancer Sci   Vol. 110 ( 4 ) page: 1364-1388   2019.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13971.

  49. Development of novel diagnostic system for pancreatic cancer, including early stages, measuring mRNA of whole blood cells

    Sakai Yoshio, Honda Masao, Matsui Shigeyuki, Komori Osamu, Murayama Toshinori, Fujiwara Tadami, Mizuno Masaaki, Imai Yasuhito, Yoshimura Kenichi, Nasti Alessandro, Wada Takashi, Iida Noriho, Kitahara Masaaki, Horii Rika, Toshikatsu Tamai, Nishikawa Masashi, Okafuji Hirofumi, Mizukoshi Eishiro, Yamashita Tatsuya, Yamashita Taro, Arai Kuniaki, Kitamura Kazuya, Kawaguchi Kazunori, Takatori Hajime, Shimakami Tetsuro, Terashima Takeshi, Hayashi Tomoyuki, Nio Kouki, Kaneko Shuichi

    CANCER SCIENCE   Vol. 110 ( 4 ) page: 1364 - 1388   2019.4

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  50. [Na+] Increases in body fluids sensed by central Nax induce sympathetically mediated blood pressure elevations via H+-dependent activation of ASIC1a Reviewed

    Nomura K, Hiyama TY, Sakuta H, Matsuda T, Lin CH, Kobayashi K, Kobayashi K, Kuwaki T, Takahashi K, Matsui S, Noda M

    Neuron   Vol. 101 ( 1 ) page: 60 - +   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neuron.2018.11.017

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  51. Exploring predictive biomarkers from clinical genome-wide association studies via multidimensional hierarchical mixture models. Reviewed

    Otani T, Noma H, Sugasawa S, Kuchiba A, Goto A, Yamaji T, Kochi Y, Iwasaki M, Matsui S, Tsunoda T.

    European Journal of Human Genetics   Vol. 27 ( 1 ) page: 140 - 149   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41431-018-0251-y

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  52. compound.Cox: univariate feature selection and compound covariate for predicting survival. Reviewed

    Emura T, Matsui S, Chen HY.

    Computer Methods and Programs in Biomedicine   Vol. 168 ( 1 ) page: 21 - 37   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cmpb.2018.10.020

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  53. Rule-Based Designs Considering Toxicity Alone

    Daimon Takashi, Hirakawa Akihiro, Matsui Shigeyuki

    DOSE-FINDING DESIGNS FOR EARLY-PHASE CANCER CLINICAL TRIALS: A BRIEF GUIDEBOOK TO THEORY AND PRACTICE     page: 9 - 32   2019

  54. Model-Based Designs Considering Toxicity Alone

    Daimon Takashi, Hirakawa Akihiro, Matsui Shigeyuki

    DOSE-FINDING DESIGNS FOR EARLY-PHASE CANCER CLINICAL TRIALS: A BRIEF GUIDEBOOK TO THEORY AND PRACTICE     page: 33 - 79   2019

  55. Model-Assisted Designs Considering Toxicity Alone

    Daimon Takashi, Hirakawa Akihiro, Matsui Shigeyuki

    DOSE-FINDING DESIGNS FOR EARLY-PHASE CANCER CLINICAL TRIALS: A BRIEF GUIDEBOOK TO THEORY AND PRACTICE     page: 81 - 94   2019

  56. Early-Phase Cancer Clinical Trials

    Daimon Takashi, Hirakawa Akihiro, Matsui Shigeyuki

    DOSE-FINDING DESIGNS FOR EARLY-PHASE CANCER CLINICAL TRIALS: A BRIEF GUIDEBOOK TO THEORY AND PRACTICE     page: 1 - 8   2019

  57. Dose-Finding Designs for Early-Phase Cancer Clinical Trials A Brief Guidebook to Theory and Practice Preface

    Daimon Takashi, Hirakawa Akihiro, Matsui Shigeyuki

    DOSE-FINDING DESIGNS FOR EARLY-PHASE CANCER CLINICAL TRIALS: A BRIEF GUIDEBOOK TO THEORY AND PRACTICE     page: VII - VIII   2019

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  58. Designs for Early-Phase Immunotherapeutic Agent Trials

    Daimon Takashi, Hirakawa Akihiro, Matsui Shigeyuki

    DOSE-FINDING DESIGNS FOR EARLY-PHASE CANCER CLINICAL TRIALS: A BRIEF GUIDEBOOK TO THEORY AND PRACTICE     page: 121 - 133   2019

  59. Designs Considering Toxicity and Efficacy

    Daimon Takashi, Hirakawa Akihiro, Matsui Shigeyuki

    DOSE-FINDING DESIGNS FOR EARLY-PHASE CANCER CLINICAL TRIALS: A BRIEF GUIDEBOOK TO THEORY AND PRACTICE     page: 95 - 120   2019

  60. Application of the Multi-Dimensional Hierarchical Mixture Model to Cross-Disorder Genome-Wide Association Studies

    Otani Takahiro, Nishino Jo, Emoto Ryo, Matsui Shigeyuki

    16TH INTERNATIONAL CONFERENCE ON INFORMATION TECHNOLOGY-NEW GENERATIONS (ITNG 2019)   Vol. 800   page: 361 - 366   2019

  61. A New Scoring System for Predicting Adverse Events in Hospitalized Patients with Community-Onset Pneumonia

    Sakakibara T., Shindo Y., Takahashi K., Kobayashi D., Okumura J., Sano M., Murakami Y., Thabet N., Kobayashi H., Yagi T., Matsui S., Saka H., Hasegawa Y.

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 199   2019

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  62. A Model-Based Framework for Voxel and Region Level Inferences in Neuroimaging Disease-Association Studies

    Emoto Ryo, Kawaguchi Atsushi, Otani Takahiro, Matsui Shigeyuki

    16TH INTERNATIONAL CONFERENCE ON INFORMATION TECHNOLOGY-NEW GENERATIONS (ITNG 2019)   Vol. 800   page: 367 - 372   2019

  63. Power and sample size calculation incorporating misspecifications of the variance function in comparative clinical trials with over-dispersed count data. Reviewed

    Igeta M, Takahashi K, Matsui S

      Vol. 74 ( 4 ) page: 1459 - 1467   2018.12

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    DOI: 10.1111/biom.12878

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  64. Comprehensive Search for Prognostic Biomarkers using PCAWG Data

    Kato Mamoru, Nagai Momoko, Hasegawa Takanori, Imoto Seiya, Matsui Shigeyuki, Tsunoda Tatsuhiko, Shibata Tatsuhiro

    CANCER SCIENCE   Vol. 109   page: 291 - 291   2018.12

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  65. Sleep, the Missing Link? Reply

    Nishikimi Mitsuaki, Numaguchi Atsushi, Takahashi Kunihiko, Matsui Shigeyuki, Matsuda Naoyuki

    CRITICAL CARE MEDICINE   Vol. 46 ( 12 ) page: E1225 - E1226   2018.12

  66. Two-stage approach based on zone and dose findings for two-agent combination Phase I/II trials

    Shimamura Fumiya, Hamada Chikuma, Matsui Shigeyuki, Hirakawa Akihiro

    JOURNAL OF BIOPHARMACEUTICAL STATISTICS   Vol. 28 ( 6 ) page: 1025 - 1037   2018.11

  67. The authors reply. Reviewed

    Nishikimi M, Numaguchi A, Takahashi K, Matsui S, Matsuda N

    Critical Care Medicine   Vol. 46 ( 10 ) page: E1010 - E1011   2018.10

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    DOI: 10.1097/CCM.0000000000003315

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  68. Prognostic impact of MSI and 18qLOH in stage II colon cancer: A prospective biomarker study in the SACURA trial

    Ishikawa T., Ishiguro M., Nakatani E., Ueno H., Uetake H., Murotani K., Matsui S., Tomita N., Shimada Y., Takahashi K., Kotake K., Watanabe M., Mochizuki H., Teramukai S., Sugihara K.

    ANNALS OF ONCOLOGY   Vol. 29   2018.10

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  69. Treatment of patients with sepsis in a closed intensive care unit is associated with improved survival: a nationwide observational study in Japan. Reviewed

    Ogura T, Nakamura Y, Takahashi K, Nishida K, Kobashi D, Matsui S

    Journal of Intensive Care 6   Vol. 6   page: 57   2018.9

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    DOI: 10.1186/s40560-018-0322-8

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  70. Personalized dynamic prediction of death according to tumour progression and high-dimensional genetic factors: Meta-analysis with a joint model. Reviewed

    Emura T, Nakatochi M, Matsui S, Michimae H, Rondeau V

    Statistical Methods in Medical Research   Vol. 27 ( 9 ) page: 2842 - 2858   2018.9

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    DOI: 10.1177/0962280216688032

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  71. Preoperative six-minute walk distance is associated with postoperative cognitive dysfunction. Reviewed

    Hayashi K, Oshima H, Shimizu M, Kobayashi K, Matsui S, Nishida Y, Usui A

    Annals of Thoracic Surgery   Vol. 106 ( 2 ) page: 505 - 512   2018.8

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    DOI: 10.1016/j.athoracsur.2018.03.010

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  72. Effect of administration of ramelteon, a melatonin receptor agonist, on the duration of stay in the ICU: A single-center randomized placebo-controlled trial. Reviewed

    Nishikimi M, Numaguchi A, Takahashi K, Miyagawa Y, Matsui K, Higashi M, Makishi G, Matsui S, Matsuda N

    Critical Care Medicine   Vol. 46 ( 7 ) page: 1099 - 1105   2018.7

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    DOI: 10.1097/CCM.0000000000003132

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  73. Differential effect of mild therapeutic hypothermia depending on the findings of hypoxic encephalopathy on early CT images in patients with post-cardiac arrest syndrome. Reviewed

    Nishikimi M, Ogura T, Nishida K, Takahashi K, Fukaya K, Liu K, Nakamura M, Matsui S, Matsuda N

    Resuscitation   Vol. 128   page: 11 - 15   2018.7

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    DOI: 10.1016/j.resuscitation.2018.04.029

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  74. Re-assessment of multiple testing strategies for more efficient genome-wide association studies. Reviewed

    Otani T, Noma H, Nishino J, Matsui S

    European Journal of Human Genetics   Vol. 26 ( 7 ) page: 1038 - 1048   2018.7

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    DOI: 10.1038/s41431-018-0125-3

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  75. Sample Size for Successful Genome-Wide Association Study of Major Depressive Disorder

    Nishino Jo, Ochi Hidenori, Kochi Yuta, Tsunoda Tatsuhiko, Matsui Shigeyuki

    FRONTIERS IN GENETICS   Vol. 9   page: 227   2018.6

  76. Sample size for successful genome-wide association study of major depressive disorder. Reviewed

    Nishino J, Ochi H, Kochi Y, Tsunoda T, Matsui S.

    Frontiers in Genetics   Vol. 9   page: 227   2018.6

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  77. The current state of therapeutic development for rare cancers in Japan, and proposals for improvement. Reviewed

    Kawai A, Goto T, Shibata T, Tani K, Mizutani S, Nishikawa A, Shibata T, Matsumoto S, Nagata K, Narukawa M, Matsui S, Ando M, Toguchida J, Monden M, Heike T, Kimura S, Ueda R

    Cancer Science   Vol. 109 ( 5 ) page: 1731 - 1737   2018.5

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    DOI: 10.1111/cas.13568

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  78. Mortality in patients with community-onset pneumonia at low risk of drug-resistant pathogens: Impact of -lactam plus macrolide combination therapy

    Okumura Junya, Shindo Yuichiro, Takahashi Kunihiko, Sano Masahiro, Sugino Yasuteru, Yagi Tetsuya, Taniguchi Hiroyuki, Saka Hideo, Matsui Shigeyuki, Hasegawa Yoshinori

    RESPIROLOGY   Vol. 23 ( 5 ) page: 526 - 534   2018.5

  79. Accuracy of the first interpretation of early brain CT images for predicting the prognosis of post-cardiac arrest syndrome patients at the emergency department. Reviewed

    Nishikimi M, Ogura T, Matsui K, Takahashi K, Fukaya K, Liu K, Morita H, Nakamura M, Matsui S, Matsuda N

    Journal of Intensive Care 6   Vol. 6   page: 26   2018.4

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    DOI: 10.1186/s40560-018-0296-6

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  80. Empirical Bayes estimation of semi-parametric hierarchical mixture models for unbiased characterization of polygenic disease architectures. Reviewed

    Nishino J, Kochi Y, Shigemizu D, Kato M, Ikari K, Ochi H, Noma H, Matsui K, Morizono T, Boroevich K, Tsunoda T, Matsui S

    Frontiers in Genetics   Vol. 9   page: 115   2018.4

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    DOI: 10.3389/fgene.2018.00115

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  81. Biomarker-Stratified Phase III Clinical Trials: Enhancement with a Subgroup-Focused Sequential Design

    Matsui Shigeyuki, Crowley John

    CLINICAL CANCER RESEARCH   Vol. 24 ( 5 ) page: 994 - 1001   2018.3

  82. Multi-subgroup gene screening using semi-parametric hierarchical mixture models and the optimal discovery procedure: Application to a randomized clinical trial in multiple myeloma

    Matsui Shigeyuki, Noma Hisashi, Qu Pingping, Sakai Yoshio, Matsui Kota, Heuck Christoph, Crowley John

    BIOMETRICS   Vol. 74 ( 1 ) page: 313 - 320   2018.3

  83. オミクス研究における検証的解析と探索的解析:多重検定とP値を中心に Reviewed

    松井 茂之

    計量生物学   Vol. 38 ( 2 ) page: 127-139   2018

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  84. A dose-response meta-analysis to coffee consumption and colorectal cancer risk in the Japanese population: Application of a cubic-spline model. Reviewed

    Horisaki K, Takahashi K, Ito H, Matsui S

    Journal of Epidemiology   Vol. 28 ( 12 ) page: 503 - 509   2018

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    DOI: 10.2188/jea.JE20170201

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  85. Immune condition of colorectal cancer patients featured by serum chemokines and gene expressions of CD4+ cells in blood. Reviewed

    Komura T, Yano M, Miyake A, Takabatake H, Miyazawa M, Ogawa N, Seki A, Honda M, Wada T, Matsui S, Kaneko S, Sakai Y.

    Canadian Journal of Gastroenterology and Hepatology   Vol. 2018   page: 7436205   2018

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    DOI: 10.1155/2018/7436205

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  86. Global overexpression of divalent metal transporter 1 delays crocidolite-induced mesothelial carcinogenesis in male mice. Reviewed

    Funahashi S, Okazaki Y, Nishiyama T, Ohyoshi H, Yasui H, Nishida K, Matsui S, Toyokuni S

    Free Radical Research   Vol. 52 ( 9 ) page: 1030 - 1039   2018

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    DOI: 10.1080/10715762.2018.1514604

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  87. Advanced Topics on Dose-Finding Designs

    Hirakawa Akihiro, Sato Hiroyuki, Daimon Takashi, Matsui Shigeyuki

    MODERN DOSE-FINDING DESIGNS FOR CANCER PHASE I TRIALS: DRUG COMBINATIONS AND MOLECULARLY TARGETED AGENTS     page: 81 - 89   2018

  88. Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents Preface

    Hirakawa Akihiro, Sato Hiroyuki, Daimon Takashi, Matsui Shigeyuki

    MODERN DOSE-FINDING DESIGNS FOR CANCER PHASE I TRIALS: DRUG COMBINATIONS AND MOLECULARLY TARGETED AGENTS     page: VII - VIII   2018

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  89. High-Flow Nasal Cannula Therapy for Acute Respiratory Failure in Patients with Interstitial Pneumonia: A Retrospective Observational Study

    Omote N., Hashimoto N., Matsuda N., Nishida K., Sakamoto K., Ando A., Nakahara Y., Nishikimi M., Higashi M., Matsui S., Hasegawa Y.

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 197   2018

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  90. Dose Finding in Phase I Cancer Trials

    Hirakawa Akihiro, Sato Hiroyuki, Daimon Takashi, Matsui Shigeyuki

    MODERN DOSE-FINDING DESIGNS FOR CANCER PHASE I TRIALS: DRUG COMBINATIONS AND MOLECULARLY TARGETED AGENTS     page: 1 - 7   2018

  91. Dose Finding for Molecularly Targeted Agents (MTAs)

    Hirakawa Akihiro, Sato Hiroyuki, Daimon Takashi, Matsui Shigeyuki

    MODERN DOSE-FINDING DESIGNS FOR CANCER PHASE I TRIALS: DRUG COMBINATIONS AND MOLECULARLY TARGETED AGENTS     page: 59 - 80   2018

  92. Dose Finding for Joint Assessment of Both Efficacy and Toxicity

    Hirakawa Akihiro, Sato Hiroyuki, Daimon Takashi, Matsui Shigeyuki

    MODERN DOSE-FINDING DESIGNS FOR CANCER PHASE I TRIALS: DRUG COMBINATIONS AND MOLECULARLY TARGETED AGENTS     page: 41 - 58   2018

  93. Dose Finding for a Combination of Two Agents

    Hirakawa Akihiro, Sato Hiroyuki, Daimon Takashi, Matsui Shigeyuki

    MODERN DOSE-FINDING DESIGNS FOR CANCER PHASE I TRIALS: DRUG COMBINATIONS AND MOLECULARLY TARGETED AGENTS     page: 9 - 40   2018

  94. Longitudinal study of visual field changes determined by Humphrey Field Analyzer 10-2 in patients with Retinitis Pigmentosa. Reviewed

    Sayo A, Ueno S, Kominami T, Nishida K, Inooka D, Nakanishi A, Yasuda S, Okado S, Takahashi K, Matsui S, Terasaki H.

    Sci Rep   Vol. 7 ( 1 ) page: 16383   2017.11

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    DOI: 10.1038/s41598-017-16640-7

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  95. IMPLICATION OF beta-LACTAM PLUS MACROLIDE COMBINATION THERAPY ON MORTALITY IN PATIENTS WITH COMMUNITY-ONSET PNEUMONIA AT LOW RISK FOR DRUG-RESISTANT PATHOGENS

    Okumura Junya, Shindo Yuichiro, Sano Masahiro, Sakakibara Toshihiro, Matsuda Toshiaki, Takahashi Kunihiko, Saka Hideo, Matsui Shigeyuki, Hasegawa Yoshinori

    RESPIROLOGY   Vol. 22   page: 271 - 271   2017.11

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  96. Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus. Reviewed

    Takagishi M, Sawada M, Ohata S, Asai N, Enomoto A, Takahashi K, Weng L, Ushida K, Ara H, Matsui S, Kaibuchi K, Sawamoto K, Takahashi M

    Cell Rep   Vol. 20 ( 4 ) page: 960 - 972   2017.7

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    DOI: 10.1016/j.celrep.2017.06.089

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  97. An efficient and flexible test for rare variant effects. Reviewed

    Sugasawa S, Noma H, Otani T, Nishino J, Matsui S

    Eur J Hum Genet   Vol. 25 ( 6 ) page: 752 - 757   2017.6

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    DOI: 10.1038/ejhg.2017.43

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  98. A novel scoring system for predicting the neurologic prognosis prior to the initiation of induced hypothermia in cases of post-cardiac arrest syndrome: the CAST score Reviewed

    Nishikimi M, Matsuda N, Matsui K, Takahashi K, Ejima T, Liu K, Ogura T, Higashi M, Umino H, Makishi G, Numaguchi A, Matsushima S, Tokuyama H, Nakamura M, Matsui S

    Scand J Trauma Resusc Emerg Med   Vol. 25 ( 1 ) page: 49   2017.5

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    DOI: 10.1186/s13049-017-0392-y

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  99. Quantifying indirect evidence in network meta-analysis Reviewed

    Noma H, Tanaka S, Matsui S, Cipriani A, Furukawa TA

    Statistics in Medicine   Vol. 36 ( 6 ) page: 917-927   2017.3

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    DOI: 10.1002

  100. Quantifying indirect evidence in network meta-analysis

    Noma Hisashi, Tanaka Shiro, Matsui Shigeyuki, Cipriani Andrea, Furukawa Toshi A.

    STATISTICS IN MEDICINE   Vol. 36 ( 6 ) page: 917 - 927   2017.3

  101. Correcting estimation bias in randomized clinical trials with a test of treatment-by-biomarker interaction Reviewed

    Toyoizumi K, Matsui S

    Statistics in Biopharmaceutical Research   Vol. 9 ( 2 ) page: 172 - 179   2017

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    DOI: 10.1080/19466315.2016.1255252

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  102. Risk Factors For Severe Adverse Outcomes In Patients With Hospital-Acquired Pneumonia

    Sano M., Shindo Y., Okumura J., Sakakibara T., Matsuda T., Yagi T., Matsui K., Takahashi K., Matsui S., Hasegawa Y.

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 195   2017

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  103. CAST: a new score for early prediction of neurological outcomes after cardiac arrest before therapeutic hypothermia with high accuracy Reviewed

    Nishikimi M, Matsuda N, Matsui K, Takahashi K, Ejima T, Liu K, Ogura T, Higashi M, Umino H, Makishi G, Numaguchi A, Matsushima S, Tokuyama H, Nakamura M, Matsui S

    Intensive Care Med   Vol. 42 ( 12 ) page: 2106-2107   2016.12

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  104. Genome-wide DNA copy-number analysis in ACTS-CC trial of adjuvant chemotherapy for stage III colonic cancer Reviewed

    Ishikawa T, Uetake H, Murotani K, Kobunai T, Ishiguro M, Matsui S, Sugihara K

    Anticancer Res   Vol. 36 ( 3 ) page: 853-860   2016.3

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  105. Association between photoreceptor regeneration and visual acuity following surgery for rhegmatogenous retinal detachment Reviewed

    Kobayashi M, Iwase T, Yamamoto K, Ra E, Murotani K, Matsui S, Terasaki H

    Invest Ophthalmol Vis Sci.   Vol. 57 ( 3 ) page: 889-898   2016.3

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    DOI: 10.1167

  106. A comparative study of adaptive dose-finding designs for phase I oncology trials of combination therapies Reviewed

    Hirakawa A, Wages NA, Sato H, Matsui S

    Statistics in Medicine   Vol. 34 ( 24 ) page: 3194-3213   2015.10

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    DOI: 10.1002/sim.6533

  107. Operative wound-related complications after cranial revascularization surgeries Reviewed

    Takanari K, Araki Y, Okamoto S, Sato H, Yagi S, Toriyama K, Yokoyama K, Murotani K, Matsui S, Wakabayashi T, Kamei Y

    J Neurosurg     2015.7

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    DOI: 10.3171/2014.12.JNS132602

  108. Sex-Related Differences in Ocular Blood Flow of Healthy Subjects Using Laser Speckle Flowgraphy Reviewed

    Yanagida K, Iwase T, Yamamoto K, Ra E, Kaneko H, Murotani K, Matsui S, Terasaki H

    Invest Ophthalmol Vis Sci   Vol. 56 ( 8 ) page: 4880-4890   2015.7

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    DOI: 10.1167/iovs.15-16567

  109. Estimation of treatment effects in all-comers randomized clinical trials with a predictive marker. Biometrics Reviewed

    Choai Y, Matsui S

    Biometrics   Vol. 71 ( 1 ) page: 25-32   2015.3

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    DOI: 10.1111/biom.12253

  110. Idiopathic sudden sensorineural hearing loss in Japan. Reviewed

    Nakashima T, Sato H, Gyo K, Hato N, Yoshida T, Shimono M, Teranishi M, Sone M, Fukunaga Y, Kobashi G, Takahashi K, Matsui S, Ogawa K

    Acta Otolaryngol     page: 1158-63   2014.11

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  111. Clinical Trials Express: fracture risk reduction with denosumab in Japanese postmenopausal women and men with osteoporosis: denosumab fracture intervention randomized placebo controlled trial (DIRECT).

    Nakamura T, Matsumoto T, Sugimoto T, Hosoi T, Miki T, Gorai I, Yoshikawa H, Tanaka Y, Tanaka S, Sone T, Nakano T, Ito M, Matsui S, Yoneda T, Takami H, Watanabe K, Osakabe T, Shiraki M, Fukunaga M

    J Clin Endocrinol Metab     page: 2599-607   2014.7

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  112. Comparison of statistical analysis plans in randomize-all phase III trials with a predictive biomarker.

    Matsui S, Choai Y, Nonaka T

    Clin Cancer Res     page: 2820-30   2014.6

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  113. Response to letter to the editor by Dr Wages et al. Stat Med.

    Hirakawa A, Matsui S

    Stat Med     page: 2159-60   2014.5

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  114. Distinct cancer-specific survival in metastatic prostate cancer patients classified by a panel of single nucleotide polymorphisms of cancer-associated genes.

    Tsuchiya N, Matsui S, Narita S, Kamba T, Mitsuzuka K, Hatakeyama S, Horikawa Y, Inoue T, Saito S, Ohyama C, Arai Y, Ogawa O, Habuchi T

    Genes Cancer     page: 54-60   2013.1

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  115. Empirical Bayes ranking and selection methods via semiparametric hierarchical mixture models in microarray studies.

    Statistics in Medicine   Vol. 32   page: 1904-1916   2013

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  116. Cancer outlier analysis based on mixture modeling of gene expression data.

    Mori K, Oura T, Noma H, Matsui S

    Computational and Mathematical Methods in Medicine     page: Article ID: 693901   2013

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  117. An empirical Bayes optimal discovery procedure based on semiparametric hierarchical mixture models.

    Noma H, Matsui S

    Computational and Mathematical Methods in Medicine     page: Article ID: 568480   2013

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  118. Genomic biomarkers for personalized medicine: development and validation in clinical studies.

    Matsui S

    Computational and Mathematical Methods in Medicine     page: Article ID: 865980   2013

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  119. A dose finding approach based on shrunken predictive probability for combinations of two agents in phase I trials

    Hirakawa A, Hamada C, Matsui S

    Statistics in Medicine   Vol. 32   page: 4515-4525   2013

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  120. Meta-analysis of oro-cecal transit time in fasting subjects

    Kokubo T, Matsui S, Ishiguro M

    Pharmaceutical Research   Vol. 30   page: 402-411   2013

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  121. Nested case control study of proteomic biomarkers for interstitial lung disease in Japanese patients with non-small-cell lung cancer treated with erlotinib: a multicenter phase 4 study (JO21661)

    Atagi S, Katakami N, Yoshioka H, Fukuoka M, Kudoh S, Ogiwara A, Imai M, Ueda M, Matsui S

    Clinical Lung Cancer   Vol. 14   page: 407-417   2013

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  122. Developing and validating continuous genomic signatures in randomized clinical trials for predictive medicine.

    Matsui S, Simon R, Qu P, Shaughnessy J, Barlogie B, Crowley J

    Clinical Cancer Research   Vol. 18   page: 6065-6073   2012

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  123. The optimal discovery procedure in multiple significance testing: an empirical Bayes approach.

    Statistics in Medicine   Vol. 31   page: 165-176   2012

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  124. Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term non-steroidal anti-inflammatory drug (NSAID) therapy: Results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial

    Sugano K, Kontani T, Katsuo S, Takei Y, Sakaki N, Ashida K, Mizokami Y, Asaka M, Matsui S, Kanto T, Soen S, Takeuchi T, Hiraishi H, Hiramatsu N

    Journal of Gastroenterology   Vol. 47   page: 540-552   2012

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  125. Endoscopic evaluation of non-steroidal anti-inflammatory drug (NSAID)-induced gastric and duodenal ulcers during prophylaxis with lansoprazole

    Sakaki N, Ashida K, Mizokami Y, Asaka M, Matsui S, Kanto T, Hiraishi H, Hiramatsu N, Sugano K

    Journal of Gastroenterology and Hepatology Research   Vol. 1   page: 260-265   2012

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  126. Study protocol of the SACURA trial: a randomized phase III trial of efficacy and safety of UFT as adjuvant chemotherapy for stage II colon cancer

    Ishiguro M, Mochizuki H, Tomita N, Shimada Y, Takahashi K, Kotake K, Watanabe M, Kanemitsu Y, Ueno H, Ishikawa T, Uetake H, Matsui S, Teramukai S, Sugihara K

    BMC Cancer   Vol. 12   page: 281   2012

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  127. Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm

    Negoro H, Kanematsu A, Doi M, Suadicani SO, Matsuo M, Imamura M, Okinami T, Nishikawa N, Oura T, Matsui S, Seo K, Tainaka M, Urabe S, Kiyokage E, Todo T, Okamura H, Tabata Y, Ogawa O

    Nature Communications   Vol. 3   page: 809   2012

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  128. Estimation and selection in high-dimensional genomic studies for developing molecular diagnostics.

    Matsui S, Noma H

    Biostatistics   Vol. 12   page: 223-233   2011

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  129. Estimating effect sizes of differentially expressed genes for power and sample size assessments in microarray experiments.

    Matsui S, Noma H

    Biometrics   Vol. 67   page: 1225-1235   2011

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  130. Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term low-dose aspirin therapy: Results of a prospective, multicenter, double-blind, randomized, double-dummy, active-control trial

    Sugano K, Matsumoto Y, Itabashi T, Abe S, Sakaki N, Ashida K, Mizokami Y, Chiba T, Matsui S, Kanto T, Shimada K, Uchiyama S, Uemura N, Hiramatsu N. for the Lansoprazole Ulcer Prevention Study Group (Low-Dose Aspirin Therapy)

    Journal of Gastoroenterogy   Vol. 46   page: 724-735   2011

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  131. Population pharmacokinetics of pregabalin in healthy subjects and patients with postherpetic neuralgia or diabetic peripheral neuropathy

    Shoji S, Suzuki M, Tomono Y, Bockbrader HN, Matsui S

    British Journal of Clinical Pharmacology   Vol. 72   page: 63-76   2011

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  132. Bayesian ranking and selection methods using hierarchical mixture models in microarray studies.

    Biostatistics   Vol. 11   page: 281-289   2010

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  133. Optimality of gene ranking based on univariate P-values for detecting differentially expressed genes

    Noma H, Matsui S

    Japanese Journal of Biometrics   Vol. 31   page: 13-21   2010

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  134. Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profiling

    Matsumura N, Mandai M, Okamoto T, Yamaguchi K, Yamamura S, Oura T, Baba T, Hamanishi J, Kang HS, Matsui S, Mori S, Murphy SK, Konishi I

    Cancer Science   Vol. 101   page: 2658-2663   2010

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  135. Medical mushrooms used for biochemical failure after radical treatment for prostate cancer: An open-label study

    Yoshimura K, Kamoto T, Ogawa O, Matsui S, Tsuchiya N, Tada H, Murata K, Yoshimura K, Habuchi T, Fukushima M

    International Journal of Urology   Vol. 17   page: 548-554   2010

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  136. Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes

    Yamaguchi K, Mandai M, Oura T, Matsumura N, Hamanishi J, Baba T, Matsui S, Murphy SK, Konishi I

    Oncogene   Vol. 29   page: 1741-1752   2010

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  137. Sample size calculations for controlling the distribution of false discovery proportion in microarray experiments.

    Oura T, Matsui S, Kawakami K

    Biostatistics   Vol. 10   page: 694-705   2009

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  138. Sample sizes for a robust ranking and selection of genes in microarray experiments.

    Matsui S, Oura T

    Statistics in Medicine   Vol. 28   page: 2801-2816   2009

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  139. Clustering of significant genes in prognostic studies with microarrays: application to a clinical study for multiple myeloma

    Matsui S, Yamanaka T, Barlogie B, Shaughnessy J, Crowley J

    Statistics in Medicine   Vol. 27   page: 1106-1120   2008

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  140. Sample size calculations based on ranking and selection in microarray experiments.

    Biometrics   Vol. 64   page: 217-226   2008

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  141. Efficacy, toxicity and cost analysis for non-platinum triplet (gemcitabine and vinorelbine followed by docetaxel) vs. platinum-based chemotherapy in IIIB/IV non-small cell lung cancer: Single institution experience

    Tada H, Matsui S, Kawahara M, Hosoe S, Hamada C, Fukushima M

    European Journal of Cancer Care   Vol. 17   page: 120-126   2008

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  142. Long-term probucol treatment prevents secondary cardiovascular events: a cohort study of patients with heterozygous familial hypercholesterolemia in Japan

    Yamashita S, Hbujo H, Arai H, Harada-Shiba M, Matsui S, Fukushima M, Saito Y, Kita T, Matsuzawa Y

    Journal of Atherosclerosis Thrombosis   Vol. 15   page: 292-303   2008

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  143. Overview of the clinical application of regenerative medicine products in Japan

    Tsubouchi M, Matsui S, Banno Y, Kurokawa K, Kawakami K

    Health Policy   Vol. 88   page: 62-72   2008

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  144. Critical issues for effective collaboration between academia and industry in the field of regenerative medicine in Japan

    Tsubouchi M, Morishita R, Tabata Y, Matsui S, Kawakami K

    Regenerative Medicine   Vol. 3   page: 497-504   2008

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  145. Genomic characterization of multiple clinical phenotypes of cancer using multivariate linear regression models.

    Matsui S, Ito M, Nishiyama H, Uno H, Kotani H, Watanabe J, Guilford P, Reeve A, Fukushima M, Ogawa O

    Bioinformatics   Vol. 23   page: 732-738   2007

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  146. P21-activated kinase 1: a new molecular marker for intravesical recurrence after transurethral resection of bladder cancer

    Ito M, Nishiyama H, Kawanishi H, Matsui S, Guilford P, Reeve A, Ogawa O

    Journal of Urology   Vol. 178   page: 1073-1079   2007

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  147. Predicting survival outcomes using subsets of significant genes in prognostic marker studies with microarrays.

    Matsui S

    BMC Bioinformatics   Vol. 7 ( 156 ) page: 1-9   2006

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  148. Reducing false positive findings in statistical analysis of pharmacogenomic biomarker studies using high-throughput technologies

    Matsui S

    Current Drug Safety2006   Vol. 1   page: 135-141   2006

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  149. Lessons from gefitinib-induced interstitial lung disease in Japan and proposal for the prevention of serious drug-induced suffering: Problems in approval, pharmacovigilance, and regulatory decision-making procedures

    Nishimura T, Tada H, Nakagawa M, Teramukai S, Matsui S, Fukushima M

    Pharmacy Practice   Vol. 4   page: 168-178   2006

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  150. Creutzfeldt-Jakob disease and cadaveric dura mater grafts in Japan: an updated analysis of incubation time

    Matsui S, Sadaike T, Hamada C, Fukushima M

    Neuroepidemiology   Vol. 24   page: 22-25   2005

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  151. Sample size calculations for comparative clinical trials with over-dispersed Poisson process data

    Matsui S

    Statistics in Medicine   Vol. 24   page: 1339-1356   2005

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  152. Stratified analysis in randomized trials with noncompliance

    Matsui S

    Biometrics   Vol. 61   page: 816-823   2005

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  153. Prognostic factor analysis for plaque psoriasis

    Sakai R, Matsui S, Fukushima M, Yasuda H, Miyauchi H, Miyachi Y

    Dermatology   Vol. 211   page: 103-106   2005

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  154. Erythropoietin as a retinal angiogenic factor

    Manzoni P, Maestri A, Gomirato G, Takagi H, Watanabe D, Matsui S

    New England Journal of Medicine   Vol. 353   page: 2190-2191   2005

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  155. Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy

    Watanabe D, Suzuma K, Matsui S, Kurimoto M, Kiryu J, Kita M, Suzuma I, Ohashi H, Ojima T, Murakami T, Kobayashi T, Masuda S, Nagao M, Yoshimura N, Takagi H

    New England Journal of Medicine   Vol. 353   page: 782-792   2005

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  156. Analysis of times to repeated events in two-arm randomized trials with noncompliance and early withdrawal Reviewed

    Matsui S

    Biometrics   Vol. 60   page: 965-976   2004

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  157. Functional assessment of self-renewal activity of male germline stem cells following cytotoxic damage and serial transplantation.

    Shinohara M, Toyokuni S, Morimoto T, Matsui S, Honjo T, Shinohara T

    Biology of Reproduction   Vol. 68   page: 1801-1807   2003

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  158. 中間解析における頻度論的アプローチ:最近の理論的展開

    松井茂之, 宇野一, 小山暢之

    計量生物学   Vol. 21   page: 87-124   2000

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  159. 中間解析におけるベイズ流アプローチ:最近の理論的展開

    宇野一, 松井茂之, 小山暢之

    計量生物学   Vol. 21   page: 125-149   2000

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  160. Analysis of recurrent events: Application to a clinical trial of colony stimulating factor with the endpoint of febrile neutropenia

    Matsui S, Ohashi Y

    Statistics in Medicine   Vol. 18   page: 2409-2420   1999

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  161. Design of clinical trials for recurrent events with periodic monitoring

    Matsui S, Miyagishi H

    Statistics in Medicine   Vol. 18   page: 3005-3020   1999

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Books 17

  1. Biomarker-based phase II and III clinical trials in oncology.

    Matsui S, Igeta M, Toyoizumi K( Role: Joint author)

    CRC Press  2019  ( ISBN:9781138083776

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    Language:English

  2. Survival Analysis with Correlated Endpoints: Joint Frailty-Copula Models

    Emura T, Chen YH, Matsui S, Rondeau V( Role: Joint author)

    Springer  2019  ( ISBN:978-981-13-3516-7

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    Total pages:136   Language:English

  3. Dose-Finding Designs for Early-Phase Cancer Clinical Trials: A Brief Guidebook to Theory and Practice

    Daimon T, Hirakawa A, Matsui S( Role: Joint author)

    Springer  2019  ( ISBN:978-4-431-55585-8

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    Total pages:152   Language:English

  4. Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combination and Molecularly Targeted Agents.

    Hirakawa A, Sato H, Daimon T, Matsui S( Role: Joint author)

    Springer  2018  ( ISBN:978-4-431-55573-5

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    Total pages:89   Language:English

  5. 新版医学統計学ハンドブック

    丹後俊郎,松井茂之( Role: Joint author)

    朝倉書店  2018  ( ISBN:978-4-254-12229-9

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    Total pages:868   Language:Japanese

  6. Frontiers of Biostatistical Methods and Applications in Clinical Oncology.

    Matsui S, Crowley J( Role: Joint author)

    Springer  2017.10 

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    Language:English Book type:Scholarly book

  7. Design and Analysis of Clinical Trials for Predictive Medicine

    Matsui S, Buyse M, Simon R( Role: Joint author)

    CRC   2015.3 

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    Language:English

  8. Univariate analysis for gene screening: beyond the multiple testing

    Noma H, Matsui S( Role: Joint author)

    CRC  2015.3 

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    Language:English

  9. Statistical issues in clinical development and validation of genomic signatures

    Matsui S( Role: Sole author)

    CRC  2015.3 

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  10. Phase III all-comers clinical trials with a predictive biomarker

    Matsui S, Choai Y, Nonaka T( Role: Joint author)

    CRC  2015.3 

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  11. Phase I dose-finding designs and their applicability to targeted therapies

    Daimon T, Hirakawa A, Matsui S( Role: Joint author)

    CRC  2015.3 

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  12. Clinical trials for predictive medicine: new paradigms and challenges. In Design and Analysis of Clinical Trials for Predictive Medicine

    Simon R, Matsui S, Buyse M( Role: Joint author)

    CRC  2015.3 

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    Language:English

  13. Developments in Statistical Evaluation of Clinical Trials

    ( Role: Joint author)

    2014 

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  14. Developments in Statistical Evaluation of Clinical Trials

    Matsui S, Nonaka T, Choai Y( Role: Joint author)

    Springer  2014 

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  15. Handbook of Statistics in Clinical Oncology, 3rd edn. (eds JJ. Crowley and A Hoering)

    Matsui S, Noma H( Role: Sole author)

    CRC Press  2012 

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    Language:English

  16. 臨床試験ハンドブック

    松井茂之( Role: Sole author)

    朝倉書店  2006 

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    Language:Japanese

  17. Handbook of Statistics in Clinical Oncology, 2nd edn. (eds J.J. Crowley and D.P. Ankerst)

    Matsui S( Role: Sole author)

    CRC Press  2006 

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Presentations 30

  1. AI医療技術の検証に向けて:現状と課題 Invited

    松井茂之

    IBISML  2021.1.18  電子情報通信学会

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    Event date: 2021.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:オンライン   Country:Japan  

  2. 医療健康データサイエンティスト:次代の担い手の育成について Invited

    松井茂之

    統計数理研究所医療健康データ科学研究センターシンポジウム  2020.11.5  統計数理研究所

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    Event date: 2020.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:オンライン  

  3. 重み付き尤度関数を用いた治療効果のバイアス補正

    - 豊泉樹一郎、松井茂之

    2020年度 統計関連学会連合大会  2020.9.12  統計関連学会連合

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  4. 脳画像を用いた疾患関連解析における神経学的,機能的領域を考慮した多重検定

    江本 遼、松井茂之

    2020年度 統計関連学会連合大会  2020.9.12  統計関連学会連合

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  5. Incorporating follow-up lengths in sample size re-estimation to compare over-dispersed count data International conference

    Masataka Igeta, Shigeyuki Matsui

    ISCB 2020  2020.8.25  International Society of Clinical Biostatistics

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    Event date: 2020.8

    Language:English   Presentation type:Poster presentation  

  6. Blinded Sample Size Re-estimation in Comparative Clinical Trials with Over-Dispersed Count Data: Incorporation of Misspecification of the Variance Function. International conference

    Masataka Igeta, Shigeyuki Matsui

    Eastern North American Region International Biometric Society, 2019 Meeting 

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    Event date: 2019.3

    Language:English   Presentation type:Poster presentation  

    Venue:Philadelphia   Country:United States  

  7. Multiple Testing and Estimation of Disease Associations Based on Semi-Parametric Hierarchical Mixture Models, Possibly Incorporating Brain Areas International conference

    Ryo Emoto, Takahiro Otani, Shigeyuki Matsui

    Eastern North American Region International Biometric Society, 2019 Meeting 

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    Event date: 2019.3

    Language:English   Presentation type:Poster presentation  

    Venue:Philadelphia   Country:United States  

  8. 生物・医学分野の新たな展開:データを中心とした拡がり/繋がり Invited

    松井茂之

    2018年度統計関連学会連合大会日本計量生物学会シンポジウム 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京(中央大学)   Country:Japan  

  9. 脳画像を用いた疾患関連解析における効果サイズ推定

    江本 遼, 川口 淳, 松井茂之

    2018年度統計関連学会連合大会 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京(中央大学)   Country:Japan  

  10. 単変量Cox回帰にもとづく遺伝子選択と複合共変量による生存期間の予測

    江村剛志、 松井 茂之、Hsuan-Yu Chen 

    2018年度統計関連学会連合大会 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京(中央大学)   Country:Japan  

  11. Hierarchical Mixture Modeling for Multiple Testing and Effect Size Estimation in Voxel-Level Inference of Neuroimaging Data. International conference

    Ryo Emoto, Atsushi Kawaguchi, Hisako Yoshida, Shigeyuki Matsui.

    Joint Statistical Meeting 2019 

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    Event date: 2018.7 - 2018.8

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Vancouver   Country:Canada  

  12. Bias-Corrected Estimation of Treatment Effects in Biomarker-Based Adaptive Subgroup Analysis: New Approach Based on Randomized Tests with Smooth Rejection Function International conference

    Kiichiro Toyoizumi, Shigeyuki Matsui

    Joint Statistical Meeting 2019 

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    Event date: 2018.7 - 2018.8

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Vancouver   Country:Canada  

  13. A Transfer Learning Method for Multi-Center Prognostic Prediction Analysis. International conference

    Kota Matsui, Kenta Kanamori, Wataru Kumagai, Mitsuaki Nishikimi, Shigeyuki Matsui

    3rd International Workshop on Biomedical Informatics with Optimization and Machine Learning in conjunction with 27th International Joint Conference on Artificial Intelligence 

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    Event date: 2018.7

    Language:English   Presentation type:Oral presentation (general)  

    Venue: Stockholm   Country:Sweden  

  14. Two-Stage Analysis for Selecting Fixed Numbers of Features in Omics Association Studies International conference

    XXIX International Biometric Conference 

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    Event date: 2018.7

    Language:English   Presentation type:Poster presentation  

    Country:Spain  

  15. Phase III Clinical Trial Design for Targeted Therapies with Uncertain Biomarker Evidence: Controversies and Solutions (Keynote). Invited International conference

    Matsui S

    OHSU Cancer Biostatistics Workshop 

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    Event date: 2018.5

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Oregon Health & Science University, Portland   Country:United States  

  16. Omics 研究における検証的解析と探索的解析 Invited

    佐藤 俊哉,三中 信宏,松井茂之,寒水 孝司

    2017 年度統計関連学会連合大会日本計量生物学会シンポジウム 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  17. セミパラメトリック階層混合モデルによる複雑疾患GWASの解析

    西野 穣, 高地 雄太, 重水 大智, 加藤 護, 猪狩 勝則, 越智 秀典, 野間 久史, 松井 孝太, 大谷隆浩, 森園 隆, 松井茂之

    第27回 日本疫学会学術総会 

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    Event date: 2017.1

    Language:Japanese   Presentation type:Poster presentation  

    Venue:甲府市   Country:Japan  

  18. セミパラメトリック階層混合モデルによる複雑疾患の遺伝的構造の推定と集団遺伝学的考察

    西野 穣, 松井茂之

    統計数理研究所公募型共同研究重点テーマ2:次世代への健康科学共通公開研究集会 

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    Event date: 2016.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:立川市   Country:Japan  

  19. Stage III結腸癌におけるDNAコピー数変化と無再発生存期間の関連~ACTS-CC試験のバイオマーカー探索

    石川敏昭,植竹宏之,石黒めぐみ,室谷健太,中谷英仁,小武内尚,松井茂之,杉原健

    第71回日本消化器外科学会総会 

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    Event date: 2016.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:徳島市   Country:Japan  

  20. Cancer Outlier Analysis Based on a Nested Two-Way Clustering International conference

    Oura T, Matsui K, Matsui S

    XXVIIIth International Biometric Conference 

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    Event date: 2016.7

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Victoria   Country:Canada  

  21. A comparison of multiple testing methods for effective strategies in genome-wide association studies International conference

    Otani T, Noma H, Nishino J, Matsui K, Matsui S

    XXVIIIth International Biometric Conference 

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    Event date: 2016.7

    Language:English   Presentation type:Poster presentation  

    Venue:Victoria   Country:Canada  

  22. 予測マーカーと治療の交互作用検定を用いるランダム化臨床試験における治療効果のバイアス補正

    豊泉樹一郎, 松井茂之

    2015年度統計関連学会連合大会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  23. ゲノムワイド関連解析データを用いた複雑疾患の階層混合モデル解析

    西野穣, 高地雄太, 野間久史, 重水大智, 森園隆, 角田達彦, 松井茂之

    2015年度統計関連学会連合大会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  24. Biomarker-based all-comers phase III trials: design issues and solutions International conference

    Matsui S

    The first Pacific Rim Cancer Biostatistics Conference 

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    Event date: 2015.8

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:United States  

  25. Bias-corrected estimation of treatment effects in biomarker-based randomized clinical trials International conference

    Toyoizumi K, Matsui S

    Joint Statistical Meetings 2015 

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    Event date: 2015.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  26. MSI, 18q LOH, and clinicopathological features in stage II sporadic colon cancers: Biomarker study in a Phase III Study of Postoperative Adjuvant Chemotherapy for Stage II Colon Cancer (SACURA trial) International conference

    Ishikawa T, Uetake H, Ishiguro M, Murotani K, Matsui S, Ueno H, Sugihara K, Tomita N, SACURA study group

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    Event date: 2015.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  27. ACTS-CC study group. CT211 biomarker search using gene expression databases in a phase III, controlled clinical trial of postoperative adjuvant chemotherapy for stage III colon cancer (ACTS-CC): correlation between clinicopathological factors and gene expression level International conference

    Uetake H, Ishikawa T, Ishiguro M, Matsui S, Sugihara K, ACTS-CC study group

    American Association for Cancer Research Annual Meeting 2015 

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    Event date: 2015.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  28. MSI, 18qLOH, and clinicopathologicalfeatures in stage II sporadic colon cancers: Biomarker study in a phase III study of postoperative adjuvantchemotherapyfor stage II colon cancer (SACURA trial) International conference

    Ishikawa T, Uetake H, Ishiguro M, Murotani K, Matsui S, Ueno H, Sugihara K, Tomita N, SACURA study group

    American Association for Cancer Research Annual Meeting 2015 

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    Event date: 2015.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  29. 計量生物学の更なる可能性を求めて

    松井茂之

    2014 年度日本計量生物学会賞受賞者講演 

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    Event date: 2015.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  30. Statistical analysis plans in phase III all-comers clinical trials with a predictive biomarker International conference

    Matsui S

    The XXVII International Biometric Conference 

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    Event date: 2014.7

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Italy  

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Works 2

  1. 「臨床試験結果の公開は倫理的、科学的に重要」

    2014

  2. がん第 I 相試験における 2 剤併用療法の用量探索法:最近の展開

    2014

Research Project for Joint Research, Competitive Funding, etc. 1

  1. 医学・医療における臨床・全ゲノム・オミックスのビッグデータ解析に基づく疾患の原因探索・亜病態分類とリスク予測

    2014.10 - 2020.3

    戦略的創造研究推進事業 

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    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 9

  1. 個別化医療の適応的臨床研究を支える統計・機械学習法に関する研究

    Grant number:21H04874  2021.4 - 2025.3

    科学研究費助成事業  基盤研究(A)

    松井 茂之, 山田 誠, 星野 崇宏, 三分一 史和, 小森 理

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    Authorship:Principal investigator 

    Grant amount:\41600000 ( Direct Cost: \32000000 、 Indirect Cost:\9600000 )

    個別化医療の臨床研究において診断法の開発と検証を同時に行う適応的アプローチに着目する。具体的には、臨床研究の小標本データを用いた機械学習による診断法開発、及び、探索的解析を踏まえた検証的解析としての統計的推測(選択的推論など)に関する方法・ツールを開発する。併せて、様々な疾患領域での事例研究を重点的に行うことで個別化医療開発の現場に役立つ方法論の構築を試みる。

  2. 個別化医療のための人工知能・深層学習に対する統計学的評価法の開発

    Grant number:19H01806  2019.4 - 2022.3

    科学研究費助成事業  基盤研究(B)

    松浦 正明, 生亀 清貴, 安藤 宗司, 牛嶋 大, 小森 理, 松井 茂之, 顧 艶紅, 江口 真透

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    Authorship:Coinvestigator(s) 

    最近、特許出願した不均一性抽出アルゴリズムの高精度化と再評価を行なう。また、深層学習の各層特徴抽出結果に対する各変数による統計学的性能評価法の検討を行い、さらに教師ありデータに対する計算機集約的統計手法を用いたデータ活用法の開発を試みる。これら手法の応用として、乳がん患者公開データに対する集団の不均一性を考慮したバイオマーカー抽出を行う
    2020年度は、計画に沿って研究を進めた。
    初年度の計画の一つは、前回の基盤研究で特許出願した「不均一性抽出アルゴリズム」の高精度化と再評価を計画し、この研究を推進した。本アルゴリズムに対しては、2018年国際計量生物学会(バルセロナ)で発表し特許開示を行った。
    2019年度はアルゴリズムの部分改良を行った。特に予測判定に関して、生存時間データへの応用を検討し、その内容をコロナで延期されていた2020年度の国際計量生物学会(ソウル)にてオンライン報告を行った。
    もう一つの研究課題の「深層学習の各層特徴抽出」については、テーブルデータを用いた場合の深層学習に特化し、各変数の統計学的性能評価法の検討を継続した。最終結果に対する各変数の寄与度を調べる最も単純な方法は、その変数を削除して同様の深層学習を行ない、どれだけ最終結果が変化するかを調べることで、その特定の変数の最終結果に対する寄与度が調査可能である。しかし、最終結果を導出した変数の数が膨大であると、その変数の個数だけ深層学習の解析を行う必要があり、膨大な時間がかかる欠点を克服する必要があり、これらについて改良・検討を進めた。
    さらに画像データに関しても、最近は画素のセットを特徴量として抽出する方法も提案されている事が調査で判明した。しかし、今後の個別化医療への応用を考えた場合は、各種検査・医療情報などのテーブルデータに対して、各変数およびそれらの変数セットの組み合わせと最終結果との関連性を寄与度として評価することが、因果関係を解明する点で重要である場合がある点も、事例研究により明らかになった。
    当初予定していた国際計量生物学会(韓国ソウル)はコロナで延期となったが、オンライン開催になったため、無事に予定通り発表を行った。さらに、テーブルデータに対する深層学習の変数寄与度の評価方法に関しても、実際の小規模データを解析することによりデータ解析での問題点を把握する事ができた。
    2021年度が本研究の最終年度である。特にテーブルデータに対して、深層学習の各層特徴抽出結果に対する各変数による統計学的性能評価法の検討を継続する。現状の性能評価の方法に関しては、これまでの研究で調査検討してきたため、今後はその改造に関して独自の方法の適用を試みる。特に実データを用いた解析に関しては、比較的小規模データを用いて、従来からの多変量回帰分析モデルでの統計解析結果と、深層学習での変数評価の結果との比較を試みて、実データ解析に対する性能評価を行う予定である。さらに独自の手法の検討を試み、成功した場合は最終的に学会での報告を行ない、可能であれば特許申請についても検討を行う。

  3. 個別化医療の開発のための統計的方法論の構築とその実践に関する総合的研究

    Grant number:16H06299  2016.5 - 2021.3

    基盤S

    松井 茂之

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    Authorship:Principal investigator 

    Grant amount:\113750000 ( Direct Cost: \87500000 、 Indirect Cost:\26250000 )

    5年間のうち4年目にあたるR1年度は最終年度を念頭におき、これまでに行ってきた研究テーマの論文化はもとより、個別化医療の開発のための統計・機械学習の方法論の整備とその実践面の評価という視点から検討を行った。
    A) 診断法の開発と評価では、前年度までに開発した階層モデルと経験ベイズ法に基づき、ベイズ因子を用いた包括的な疾患関連解析、複雑な相関構造をもつ脳画像データを用いた疾患関連解析について統計的手法の開発を行った。疾患の異質性解析では、HSIC lasso, factorization machine、各種カーネル法などの非線形モデリング解析の適用について検討した。併せて、ゲノム、トランスクリトーム、プロテームなどの多層オミックスの解析において、分子生物学上の知見を考慮した薬剤副作用予測、薬剤反応性・疾患特異性の検出・予測のためのアルゴリズムを多く開発した。
    B) 診断法を用いたランダム化臨床試験では、診断法により分類される患者サブグループ別の治療効果をベイズ流事後確率で捉え、その統計的有意性を評価する枠組みを構築した(頻度論とベイズ流アプローチの融合)。また、クロスオーバーデザインなどの自己対照デザインを用いたより効率的な治療効果予測解析(検証含む)を開発した。
    C) 最適な治療シーケンスの探索解析では、事例研究として救急現場における心臓波形予測に着手し、解析計画書の検討とともにデータベースの整理を行った。
    以上の統計的方法論の検討に併せて、各種がん、二型糖尿病、救急など、多様な疾患領域での事例研究を行った。
    初年度に同定した研究テーマの大半でかなりの進捗が得られており、統計・機械学習の方法開発、事例研究の双方で多くの論文を発表した。本研究プロジェクトの遂行では主に二つの方向性を意識している。一つはチャレンジングなテーマへの取り組みである。ステージA:診断法の開発と評価、ステージB:診断法に基づく治療法の有効性・安全性の検証、ステージC:診断法・治療法のエビデンス統合、ともに、一部のテーマ(学習曲線の推定など)を除き、多くのテーマで解決に向けて見通しをつけることができたと考えている。もう一つの方向性は、開発した統計・機械学習の方法を実践面の観点から評価することである。ほぼすべての方法論に対して特定の疾患領域、事例研究をマッチングできており、今後も順調に評価を行うことができると見込んでいる。海外との共同研究においては、新たに英国のニューカッスル大のグループと交流を開始し、多くのテーマ(マスタープロトコル試験のデザインなど)で共同研究を行うこととなった。以上より、おおむね順調に進展していると判断する。
    来年度は最終年度にあたり、上記の二つの方向性でプロジェクト全体の成果をまとめる。すなわち、チャレンジングな課題に取り組みつつも、これまでの成果を統計的方法論とその実践の観点から整理し、指針をまとめる。個別の研究課題への取り組みについては次の通りである。分子診断マーカーの検出では、階層混合モデルと経験ベイズ推定の枠組みのもと、複数の個体グループの解析などへの拡張とともに、ベイズ因子などを用いて個々のマーカーの評価指標を確立する。また、これまで開発した各種非線形モデリング(factorization machine, カーネル法、localized lassoなど)を国内救急系学会の学会データベース等(例:救急での心臓波形予測等)に適用し、その有効性、有用性を評価する。診断法を用いた臨床試験による検証では、前年度に構築した頻度論とベイズ流のアプローチを融合した新しい臨床試験デザインの枠組みを具現化し、その性能を評価する。また、昨年度開発した同一個体で複数の治療を評価する自己対照デザイン(クロスオーバーデザインなど)での治療効果予測解析法についてはその有効性の評価を二型糖尿病の臨床試験への適用と数値実験を通して行う。診断法を用いた個別化医療を支援するツールの開発として、患者のきめ細かな情報をインプットとした最適治療同定のための強化学習、効用関数の偏りのない推定(内的妥当性と外的妥当性の評価)のための統計的方法を整理し、救急や院内感染症等の国内外データベースへの適用を通して、その有効性、有用性の評価を行う。

  4. 個別化医療の開発のための統計的方法論の構築とその実践に関する総合的研究

    2016.4 - 2020.3

    科学研究費補助金  基盤研究(S)

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    Authorship:Principal investigator 

  5. A new framework of discrimination analysis for high-dimensional data based on estimation of data structure

    Grant number:16K12401  2016.4 - 2019.3

    Matsui Shigeyuki

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    Authorship:Principal investigator 

    Grant amount:\3120000 ( Direct Cost: \2400000 、 Indirect Cost:\720000 )

    We developed a novel framework of discrimination analysis of phenotype classes using high-dimensional genomic data in biomedical researches. This framework is based on hierarchical mixture models of the underlying structure on the association between the phonotype and genomic data and is expected to allow for stable discrimination and also for estimation of discrimination accuracy based on the model. We also considered incorporation of disease heterogeneity at the molecular level. One approach is the use of nested mixture models that can identify clusters of genes that are associated with the phonotype in particular subsets of disease patients. We applied the developed methods to real datasets from clinical genomic researches in cancer and other diseases.

  6. 多次元データ解析の新しい枠組み:構造推定と判別解析

    2016.4 - 2018.3

    科学研究費補助金 

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  7. Development of statistical methods based on omics data for realizing predictive medicine

    Grant number:15H02671  2015.4 - 2019.3

    Matsuura Masaaki

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    Authorship:Coinvestigator(s) 

    In this study, we developed a novel algorithm to detect unsupervised clusters based on data similarity. A patent application (Japan) was filed in 2016 for a system equipped with this algorithm, and an improved patent was filed in 2017. Furthermore, in 2017 we applied for foreign patents to the United States and China.
    Regarding the method to determine whether the above contents and algorithm are applicable, we made presentations at the XXIXth International Biometric Conference (Barcelona) and the Annual Scientific meeting of the Japan Epidemiological Association in 2017 and 2018. In order to further improve the accuracy of this algorithm, we were able to apply for research including new issues.

  8. 先端医療技術の開発における臨床試験の計画と統計解析に関する研究

    2014.4 - 2018.3

    科学研究費補助金  基盤研究(A)

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    Authorship:Principal investigator 

  9. Statistical methodology for stabilizing of the genome-omics data analysis

    Grant number:25280008  2013.4 - 2018.3

    Egichi Shinto

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    Authorship:Coinvestigator(s) 

    In genome and omics data analysis we aimed at exploiting new statistical methods to challenge a difficult aspect caused by high-dimensional small-sample observations. In particular, we have proposed and published statistical methods and practical algorithms for prediction for treatment effect and prognosis based on genome and omics data beyond existing methods. In major contributions the subsampling replication method for a gene ranking was presented for a stable ranking, and a new modeling, called quasi-linear model, was proposed to incorporate different linear predictors into an integrated predictor connecting by a generalized mean.

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Teaching Experience (On-campus) 8

  1. 社会医学

    2020

  2. 臨床統計学・レギュラトリーサイエンス

    2020

  3. 生物統計学実験研究

    2020

  4. 生物統計学セミナー

    2020

  5. 応用統計学

    2020

  6. 医薬統合プログラム

    2020

  7. 医科学セミナー・医科学実験研究

    2020

  8. 医学入門

    2020

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Social Contribution 1

  1. 日本医薬品医療機器総合機構専門委員

Media Coverage 2

  1. ワクチン治験の簡略化 残る課題 Newspaper, magazine

    朝日新聞  2021.11

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    Author:Other 

  2. 国産ワクチンの壁、治験方法変更で突破目指す 国内企業も準備 Newspaper, magazine

    朝日新聞  2021.9

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    Author:Other 

Academic Activities 8

  1. 日本計量生物学会会長

    Role(s):Planning, management, etc.

    2020.1 - 2022.12

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  2. 統計関連学会連合理事

    Role(s):Planning, management, etc.

    2020.1 - 2020.12

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  3. Current Drug Safety

    Role(s):Planning, management, etc.

    2020.1 - 2020.12

  4. Annals of Oncology Editorial Board

    Role(s):Planning, management, etc.

    2020.1 - 2020.12

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  5. 日本メディカルAI学会 評議員

    Role(s):Planning, management, etc.

    2020.1 - 2020.12

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  6. 日本統計学会JSS-Springer 編集委員

    Role(s):Planning, management, etc.

    2020.1 - 2020.12

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  7. 日本統計学会 JJSD支援委員

    Role(s):Planning, management, etc.

    2020.1 - 2020.12

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    Type:Academic society, research group, etc. 

  8. Japanese Journal of Statistics and Data Science, Coordinating Editor

    Role(s):Planning, management, etc.

    2020.1 - 2020.12

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