Updated on 2024/03/21

写真a

 
MATSUI Shigeyuki
 
Organization
Graduate School of Medicine Program in Integrated Medicine Clinical Pharmacology Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine
Title
Professor
Contact information
メールアドレス
External link

Degree 1

  1. Ph.D. ( 1999.3   Tokyo University of Science ) 

Research Areas 1

  1. Others / Others  / Biostatistics

Awards 1

  1. 日本計量生物学会 2014年学会賞

    2014.5   日本計量生物学会  

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    Country:Japan

 

Papers 184

  1. CHST4 Gene as a Potential Predictor of Clinical Outcome in Malignant Pleural Mesothelioma

    Okado, S; Kato, T; Hanamatsu, Y; Emoto, R; Imamura, Y; Watanabe, H; Kawasumi, Y; Kadomatsu, Y; Ueno, H; Nakamura, S; Mizuno, T; Takeuchi, T; Matsui, S; Chen-Yoshikawa, TF

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 25 ( 4 )   2024.2

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  2. Prediction of the neurological outcomes post-cardiac arrest: A prospective validation of the CAST and rCAST

    Kikutani, K; Nishikimi, M; Matsui, K; Sakurai, A; Hayashida, K; Kitamura, N; Tagami, T; Nakada, T; Matsui, S; Ohshimo, S; Shime, N

    AMERICAN JOURNAL OF EMERGENCY MEDICINE   Vol. 75   page: 46 - 52   2024.1

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  3. Efficacy of Endoscopic Ultrasound-guided Celiac Plexus Neurolysis for Abdominal Pain in Patients With Unresectable Pancreatic Cancer

    Okita, M; Otani, K; Matsui, S

    JOURNAL OF CLINICAL GASTROENTEROLOGY   Vol. 57 ( 10 ) page: 1054 - 1062   2023.11

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  4. Prognostic impact of highly solid component in early-stage solid lung adenocarcinoma

    Kato, T; Iwano, S; Hanamatsu, Y; Nakaguro, M; Emoto, R; Okado, S; Sato, K; Noritake, O; Nakanishi, K; Kadomatsu, Y; Ueno, H; Ozeki, N; Nakamura, S; Fukumoto, K; Takeuchi, T; Karube, K; Matsui, S; Chen-Yoshikawa, TF

    QUANTITATIVE IMAGING IN MEDICINE AND SURGERY   Vol. 13 ( 9 ) page: 5641 - +   2023.9

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  5. The prognostic impact of limited-staging surgery in patients with stage IA epithelial ovarian cancer: a multi-center study with a propensity score-adjusted analysis

    Miyamoto, E; Suzuki, H; Yoshihara, M; Mogi, K; Iyoshi, S; Uno, K; Fujimoto, H; Kitami, K; Tano, S; Emoto, R; Matsui, S; Kajiyama, H

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 53 ( 8 ) page: 698 - 703   2023.7

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  6. Systematic Review and Meta-Analysis of the Use of Serum Leucine-Rich Alpha-2 Glycoprotein to Assess Crohn's Disease Activity

    Okita, M; Nakashima, K; Yamamura, T; Matsui, S

    INFLAMMATORY BOWEL DISEASES     2023.7

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  7. Evaluating glucose variability through OGTT in early pregnancy and its association with hypertensive disorders of pregnancy in non-diabetic pregnancies: a large-scale multi-center retrospective study

    Tano, S; Kotani, T; Ushida, T; Yoshihara, M; Imai, K; Nakamura, N; Iitani, Y; Moriyama, Y; Emoto, R; Kato, S; Yoshida, S; Yamashita, M; Kishigami, Y; Oguchi, H; Matsui, S; Kajiyama, H

    DIABETOLOGY & METABOLIC SYNDROME   Vol. 15 ( 1 ) page: 123   2023.6

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  8. Factors associated with adverse drug reactions or death in very elderly hospitalized patients with pulmonary tuberculosis

    Yagi, M; Shindo, Y; Mutoh, Y; Sano, M; Sakakibara, T; Kobayashi, H; Matsuura, A; Emoto, R; Matsui, S; Nakagawa, T; Ogawa, K

    SCIENTIFIC REPORTS   Vol. 13 ( 1 ) page: 6826   2023.4

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  9. Impact of obesity and the role of dedifferentiated adipocytes upon peritoneal metastasis of ovarian cancer

    Iyoshi, S; Yoshihara, M; Nakamura, K; Sumi, A; Sugiyama, M; Koya, Y; Miyamoto, E; Fujimoto, H; Mogi, K; Uno, K; Kitami, K; Emoto, R; Matsui, S; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 114   page: 978 - 978   2023.2

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  10. Effect of omega-3 fatty acids on cardiovascular events in high-risk patients with hypertriglyceridemia in Japan: a 3-year post-marketing surveillance study (OCEAN3 survey)

    Teramoto, T; Ogawa, H; Ueshima, H; Okada, Y; Haze, K; Matsui, S; Fujikawa, K; Hashimoto, T; Sakui, S; Nishimura, K; Kajita, M; Horimoto, A; Fernandez, J

    EXPERT OPINION ON DRUG SAFETY   Vol. 22 ( 1 ) page: 81 - 90   2023.1

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  11. Blinded sample size re-estimation for comparing over-dispersed count data incorporating follow-up lengths

    Igeta, M; Matsui, S

    STATISTICS IN MEDICINE   Vol. 41 ( 29 ) page: 5622 - 5644   2022.12

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  12. Bias correction based on weighted likelihood for conditional estimation of subgroup effects in randomized clinical trials

    Toyoizumi, K; Matsui, S

    STATISTICS IN MEDICINE   Vol. 41 ( 26 ) page: 5276 - 5289   2022.11

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  13. Extended-spectrum antibiotics for community-acquired pneumonia with a low risk for drug-resistant pathogens

    Kobayashi, H; Shindo, Y; Kobayashi, D; Sakakibara, T; Murakami, Y; Yagi, M; Matsuura, A; Sato, K; Matsui, K; Emoto, R; Yagi, T; Saka, H; Matsui, S; Hasegawa, Y

    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES   Vol. 124   page: 124 - 132   2022.11

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  14. Epicardial adipose tissue volume is associated with abdominal aortic aneurysm expansion

    Kawai, Y; Banno, H; Sato, T; Ikeda, S; Tsuruoka, T; Sugimoto, M; Niimi, K; Kodama, A; Matsui, K; Matsui, S; Komori, K

    JOURNAL OF VASCULAR SURGERY   Vol. 76 ( 5 ) page: 1253 - 1260   2022.11

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  15. Who are the long-term survivors of recurrent ovarian carcinoma?: a retrospective analysis of a multicenter study

    Yoshihara, M; Mogi, K; Kitami, K; Uno, K; Iyoshi, S; Tano, S; Fujimoto, H; Miyamoto, E; Yoshikawa, N; Emoto, R; Matsui, S; Kajiyama, H

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 27 ( 10 ) page: 1660 - 1668   2022.10

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  16. Systematic review and meta-analysis of celiac plexus neurolysis for abdominal pain associated with unresectable pancreatic cancer

    Okita, M; Otani, K; Gibo, N; Matsui, S

    PAIN PRACTICE   Vol. 22 ( 7 ) page: 652 - 661   2022.9

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  17. Effects of lymphocyte and neutrophil counts and their time courses on mortality in patients with postoperative pneumonia

    Murakami, Y; Shindo, Y; Sano, M; Okumura, J; Kobayashi, H; Sakakibara, T; Iguchi, M; Takahashi, K; Yagi, T; Matsui, S; Hasegawa, Y

    SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page: 14564   2022.8

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  18. Obesity contributes to the stealth peritoneal dissemination of ovarian cancer: a multi-institutional retrospective cohort study

    Iyoshi, S; Sumi, A; Yoshihara, M; Kitami, K; Mogi, K; Uno, K; Fujimoto, H; Miyamoto, E; Tano, S; Yoshikawa, N; Emoto, R; Matsui, S; Kajiyama, H

    OBESITY   Vol. 30 ( 8 ) page: 1599 - 1607   2022.8

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  19. The finger-to-nose test improved diagnosis of cerebrovascular events in patients presenting with isolated dizziness in the emergency department

    Nishida, K; Usami, T; Matsumoto, N; Nishikimi, M; Takahashi, K; Matsui, S

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 3 ) page: 621 - 629   2022.8

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  20. Machine learning prediction models for postpartum depression: A multicenter study in Japan

    Matsuo, S; Ushida, T; Emoto, R; Moriyama, Y; Iitani, Y; Nakamura, N; Imai, K; Nakano-Kobayashi, T; Yoshida, S; Yamashita, M; Matsui, S; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 48 ( 7 ) page: 1775 - 1785   2022.7

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  21. Prediction of Prehospital Change of the Cardiac Rhythm From Nonshockable to Shockable in Out-of-Hospital Patients With Cardiac Arrest: A Post Hoc Analysis of a Nationwide, Multicenter, Prospective Registry

    Emoto, R; Nishikimi, M; Shoaib, M; Hayashida, K; Nishida, K; Kikutani, K; Ohshimo, S; Matsui, S; Shime, N; Iwami, T

    JOURNAL OF THE AMERICAN HEART ASSOCIATION   Vol. 11 ( 12 ) page: e025048   2022.6

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  22. Risk factors for antibiotic resistance in hospital-acquired and ventilator-associated pneumonia

    Sano, M; Shindo, Y; Takahashi, K; Okumura, J; Sakakibara, T; Murakami, Y; Iguchi, M; Yagi, T; Matsui, S; Hasegawa, Y

    JOURNAL OF INFECTION AND CHEMOTHERAPY   Vol. 28 ( 6 ) page: 745 - 752   2022.6

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  23. Broad-Spectrum Antibiotics and Mortality in Community-Acquired Pneumonia Patients with Low-Risk for Drug-Resistant Pathogens

    Kobayasi, H; Shindo, Y; Kobayashi, D; Sakakibara, T; Murakami, Y; Yagi, M; Matsuura, A; Sato, K; Goto, Y; Matsui, S; Yagi, T; Saka, H; Hasegawa, Y

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 205   2022.5

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    Language:Japanese  

    Web of Science

  24. Dynamic Risk Prediction via a Joint Frailty-Copula Model and IPD Meta-Analysis: Building Web Applications

    Emura, T; Michimae, H; Matsui, S

    ENTROPY   Vol. 24 ( 5 )   2022.5

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  25. A prediction rule for severe adverse events in all inpatients with community-acquired pneumonia: a multicenter observational study

    Sakakibara, T; Shindo, Y; Kobayashi, D; Sano, M; Okumura, J; Murakami, Y; Takahashi, K; Matsui, S; Yagi, T; Saka, H; Hasegawa, Y

    BMC PULMONARY MEDICINE   Vol. 22 ( 1 ) page: 34   2022.1

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  26. Clinical paper The rCAST score is useful for estimating the neurological prognosis in pediatric patients with post-cardiac arrest syndrome before ICU admission: External validation study using a nationwide prospective registry

    Yasuda, Y; Nishikimi, M; Matsui, K; Numaguchi, A; Nishida, K; Emoto, R; Matsui, S; Matsuda, N

    RESUSCITATION   Vol. 168   page: 103 - 109   2021.11

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  27. Hypofibrinogenemia can be estimated by the predictive formula in aortic surgery

    Nishi, T; Mutsuga, M; Akita, T; Narita, Y; Fujimoto, K; Tokuda, Y; Nishida, K; Matsui, S; Nishiwaki, K; Usui, A

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   Vol. 69 ( 10 ) page: 1376 - 1382   2021.10

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  28. Postoperative stroke and neurological outcomes in the early phase after revascularization surgeries for moyamoya disease: an age-stratified comparative analysis

    Araki, Y; Yokoyama, K; Uda, K; Kanamori, F; Kurimoto, M; Shiba, Y; Mamiya, T; Nishihori, M; Izumi, T; Sumitomo, M; Okamoto, S; Matsui, K; Emoto, R; Wakabayashi, T; Matsui, S; Natsume, A

    NEUROSURGICAL REVIEW   Vol. 44 ( 5 ) page: 2785 - 2795   2021.10

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  29. Clinical impact of visually assessed right ventricular dysfunction in patients with septic shock

    Hiraiwa, H; Kasugai, D; Ozaki, M; Goto, Y; Jingushi, N; Higashi, M; Nishida, K; Kondo, T; Furusawa, K; Morimoto, R; Okumura, T; Matsuda, N; Matsui, S; Murohara, T

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 18823   2021.9

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  30. Outcome Related to Level of Targeted Temperature Management in Postcardiac Arrest Syndrome of Low, Moderate, and High Severities: A Nationwide Multicenter Prospective Registry

    Nishikimi, M; Ogura, T; Nishida, K; Hayashida, K; Emoto, R; Matsui, S; Matsuda, N; Iwami, T

    CRITICAL CARE MEDICINE   Vol. 49 ( 8 ) page: E741 - E750   2021.8

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  31. A large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer

    Yoshihara, M; Emoto, R; Kitami, K; Iyoshi, S; Uno, K; Mogi, K; Tano, S; Yoshikawa, N; Matsui, S; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 15154   2021.7

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  32. Relative platelet reductions provide better pathophysiologic signatures of coagulopathies in sepsis

    Kasugai, D; Ozaki, M; Nishida, K; Goto, Y; Takahashi, K; Matsui, S; Matsuda, N

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 14033   2021.7

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  33. The interplay between bystander cardiopulmonary resuscitation and ambient temperature on neurological outcome after cardiac arrest: A nationwide observational cohort study

    Hayashida, K; Takegawa, R; Nishikimi, M; Aoki, T; Emoto, R; Shinozaki, K; Miyara, SJ; Rolston, DM; Li, T; Shoaib, M; Fukuda, T; Molmenti, EP; Suzuki, M; Sasaki, J; Matsui, S; Becker, LB

    RESUSCITATION   Vol. 164   page: 46 - 53   2021.7

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  34. Statistical Models in Clinical Studies

    Matsui, S; Le-Rademacher, J; Mandrekar, SJ

    JOURNAL OF THORACIC ONCOLOGY   Vol. 16 ( 5 ) page: 734 - 739   2021.5

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  35. Semi-parametric empirical Bayes factor for genome-wide association studies

    Morisawa, J; Otani, T; Nishino, J; Emoto, R; Takahashi, K; Matsui, S

    EUROPEAN JOURNAL OF HUMAN GENETICS   Vol. 29 ( 5 ) page: 800 - 807   2021.5

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  36. Failure of non-invasive respiratory support after 6 hours from initiation is associated with ICU mortality

    Nishikimi, M; Nishida, K; Shindo, Y; Shoaib, M; Kasugai, D; Yasuda, Y; Higashi, M; Numaguchi, A; Yamamoto, T; Matsui, S; Matsuda, N

    PLOS ONE   Vol. 16 ( 4 ) page: e0251030   2021.4

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  37. Blinded Sample Size Re-Estimation in Comparative Clinical Trials With Overdispersed Count Data: Incorporation of Misspecification of the Variance Function

    Igeta, M; Matsui, S

    STATISTICS IN BIOPHARMACEUTICAL RESEARCH   Vol. 13 ( 2 ) page: 170 - 180   2021.4

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  38. Prognostic value of desmoplastic reaction characterisation in stage II colon cancer: prospective validation in a Phase 3 study (SACURA Trial)

    Ueno, H; Ishiguro, M; Nakatani, E; Ishikawa, T; Uetake, H; Murotani, K; Matsui, S; Teramukai, S; Sugai, T; Ajioka, Y; Maruo, H; Kotaka, M; Tsujie, M; Munemoto, Y; Yamaguchi, T; Kuroda, H; Fukunaga, M; Tomita, N; Sugihara, K

    BRITISH JOURNAL OF CANCER   Vol. 124 ( 6 ) page: 1088 - 1097   2021.3

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  39. Does complete-staging lymphadenectomy improve survival outcomes in stage I endometrioid epithelial ovarian carcinoma? A multi-institutional retrospective study with propensity score-weighted analysis

    Yoshihara, M; Tamauchi, S; Iyoshi, S; Kitami, K; Uno, K; Tano, S; Matsui, S; Kajiyama, H

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 51 ( 3 ) page: 387 - 392   2021.3

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  40. Effect-Size Estimation Using Semiparametric Hierarchical Mixture Models in Disease-Association Studies with Neuroimaging Data

    Emoto, R; Kawaguchi, A; Takahashi, K; Matsui, S

    COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE   Vol. 2020   page: 7482403   2020.12

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  41. Optimal Criteria for G3 (Poorly Differentiated) Stage II Colon Cancer Prospective Validation in a Randomized Controlled Study (SACURA Trial)

    Ueno, H; Ishiguro, M; Nakatani, E; Ishikawa, T; Uetake, H; Matsui, S; Teramukai, S; Murotani, K; Ajioka, Y; Shimazaki, H; Maeda, A; Takuma, K; Yoshida, T; Kambara, T; Matsuda, K; Takagane, A; Tomita, N; Sugihara, K

    AMERICAN JOURNAL OF SURGICAL PATHOLOGY   Vol. 44 ( 12 ) page: 1685 - 1698   2020.12

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  42. Relationship Between Bone Mineral Density and Risk of Vertebral Fractures with Denosumab Treatment in Japanese Postmenopausal Women and Men with Osteoporosis

    Okubo, N; Matsui, S; Matsumoto, T; Sugimoto, T; Hosoi, T; Osakabe, T; Watanabe, K; Takami, H; Shiraki, M; Nakamura, T

    CALCIFIED TISSUE INTERNATIONAL   Vol. 107 ( 6 ) page: 559 - 566   2020.12

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  43. Desmoid with biweekly methotrexate and vinblastine shows similar effects to weekly administration: A phase II clinical trial

    Nishida, Y; Hamada, S; Urakawa, H; Ikuta, K; Sakai, T; Koike, H; Ito, K; Emoto, R; Ando, Y; Matsui, S

    CANCER SCIENCE   Vol. 111 ( 11 ) page: 4187 - 4194   2020.11

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  44. Maximum Norepinephrine Dosage Within 24 Hours as an Indicator of Refractory Septic Shock: A Retrospective Study

    Kasugai, D; Hirakawa, A; Ozaki, M; Nishida, K; Ikeda, T; Takahashi, K; Matsui, S; Uenishi, N

    JOURNAL OF INTENSIVE CARE MEDICINE   Vol. 35 ( 11 ) page: 1285 - 1289   2020.11

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  45. The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies

    Kumagai, S; Togashi, Y; Kamada, T; Sugiyama, E; Nishinakamura, H; Takeuchi, Y; Vitaly, K; Itahashi, K; Maeda, Y; Matsui, S; Shibahara, T; Yamashita, Y; Irie, T; Tsuge, A; Fukuoka, S; Kawazoe, A; Udagawa, H; Kirita, K; Aokage, K; Ishii, G; Kuwata, T; Nakama, K; Kawazu, M; Ueno, T; Yamazaki, N; Goto, K; Tsuboi, M; Mano, H; Doi, T; Shitara, K; Nishikawa, H

    NATURE IMMUNOLOGY   Vol. 21 ( 11 ) page: 1346 - +   2020.11

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  46. Impact of uterus-preserving surgery on Stage I primary mucinous epithelial ovarian carcinoma: A multi-institutional study with propensity score-weighted analysis

    Yoshihara, M; Kajiyama, H; Tamauchi, S; Iyoshi, S; Yokoi, A; Suzuki, S; Kawai, M; Nagasaka, T; Takahashi, K; Matsui, S; Kikkawa, F

    INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS   Vol. 150 ( 2 ) page: 177 - 183   2020.8

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  47. High-flow nasal cannula therapy for acute respiratory failure in patients with interstitial pneumonia: a retrospective observational study.

    Omote N, Matsuda N, Hashimoto N, Nishida K, Sakamoto K, Ando A, Nakahara Y, Nishikimi M, Higashi M, Matsui S, Hasegawa Y

    Nagoya journal of medical science   Vol. 82 ( 2 ) page: 301 - 313   2020.5

  48. Relationship Between Serum Norepinephrine Levels at ICU Admission and the Risk of ICU-Acquired Delirium: Secondary Analysis of the Melatonin Evaluation of Lowered Inflammation of ICU Trial.

    Yasuda Y, Nishikimi M, Nishida K, Takahashi K, Numaguchi A, Higashi M, Matsui S, Matsuda N

    Critical care explorations   Vol. 2 ( 2 ) page: e0082   2020.2

  49. A single paravertebral injection via a needle vs. a catheter for the spreading to multiple intercostal levels: a randomized controlled trial

    Fujii, T; Shibata, Y; Ban, Y; Shitaokoshi, A; Takahashi, K; Matsui, S; Nishiwaki, K

    JOURNAL OF ANESTHESIA   Vol. 34 ( 1 ) page: 72 - 78   2020.2

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  50. Prognostic impact of pelvic and para-aortic lymphadenectomy on clinically-apparent stage I primary mucinous epithelial ovarian carcinoma: a multi-institutional study with propensity score-weighted analysis

    Yoshihara, M; Kajiyama, H; Tamauchi, S; Iyoshi, S; Yokoi, A; Suzuki, S; Kawai, M; Nagasaka, T; Takahashi, K; Matsui, S; Kikkawa, F

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 50 ( 2 ) page: 145 - 151   2020.2

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  51. Diagnosis of central diabetes insipidus using a vasopressin radioimmunoassay during hypertonic saline infusion

    Takagi, H; Hagiwara, D; Handa, T; Sugiyama, M; Onoue, T; Tsunekawa, T; Ito, Y; Iwama, S; Goto, M; Suga, H; Banno, R; Takahashi, K; Matsui, S; Arima, H

    ENDOCRINE JOURNAL   Vol. 67 ( 3 ) page: 267 - 274   2020

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  52. More Powerful Selective Kernel Tests for Feature Selection

    Lim Jen Ning, Yamada Makoto, Jitkrittum Wittawat, Terada Yoshikazu, Matsui Shigeyuki, Shimodaira Hidetoshi

    INTERNATIONAL CONFERENCE ON ARTIFICIAL INTELLIGENCE AND STATISTICS, VOL 108   Vol. 108   page: 820 - 829   2020

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  53. A randomised controlled trial of pectoral nerve-2 (PECS 2) block vs. serratus plane block for chronic pain after mastectomy. Reviewed

    Fujii T, Shibata Y, Akane A, Aoki W, Sekiguchi A, Takahashi K, Matsui S, Nishiwaki K

    Anaesthesia   Vol. 74 ( 12 ) page: 1558 - 1562   2019.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/anae.14856

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    PubMed

  54. Clinical Frailty Scale Score Before ICU Admission Is Associated With Mobility Disability in Septic Patients Receiving Early Rehabilitation.

    Nakajima H, Nishikimi M, Shimizu M, Hayashi K, Inoue T, Nishida K, Takahashi K, Matsui S, Nishida Y, Matsuda N

    Critical care explorations   Vol. 1 ( 12 ) page: e0066   2019.12

  55. Prognostic factors and effects of fertility-sparing surgery in women of reproductive age with ovarian clear-cell carcinoma: a propensity score analysis. Reviewed

    Yoshihara M, Kajiyama H, Tamauchi S, Suzuki S, Takahashi K, Matsui S, Kikkawa F

    J Gynecol Oncol   Vol. 30 ( 6 ) page: e102   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3802/jgo.2019.30.e102.

  56. Prognostic factors and effects of fertility-sparing surgery in women of reproductive age with ovarian clear-cell carcinoma: a propensity score analysis

    Yoshihara, M; Kajiyama, H; Tamauchi, S; Suzuki, S; Takahashi, K; Matsui, S; Kikkawa, F

    JOURNAL OF GYNECOLOGIC ONCOLOGY   Vol. 30 ( 6 ) page: e102   2019.11

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  57. Prospective Multicenter Study on the Prognostic and Predictive Impact of Tumor Budding in Stage II Colon Cancer: Results From the SACURA Trial. Reviewed

    Ueno H, Ishiguro M, Nakatani E, Ishikawa T, Uetake H, Matsuda C, Nakamoto Y, Kotake M, Kurachi K, Egawa T, Yasumasa K, Murata K, Ikawa O, Shinji S, Murotani K, Matsui S, Teramukai S, Tomita N, Sugihara K

    J Clin Oncol   Vol. 37 ( 22 ) page: 1886-1894   2019.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1200/JCO.18.02059.

  58. Prospective Multicenter Study on the Prognostic and Predictive Impact of Tumor Budding in Stage II Colon Cancer: Results From the SACURA Trial

    Ueno, H; Ishiguro, M; Nakatani, E; Ishikawa, T; Uetake, H; Matsuda, C; Nakamoto, Y; Kotake, M; Kurachi, K; Egawa, T; Yasumasa, K; Murata, K; Ikawa, O; Shinji, S; Murotani, K; Matsui, S; Teramukai, S; Tomita, N; Sugihara, K

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 37 ( 22 ) page: 1886 - +   2019.8

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  59. Two-stage analysis for selecting fixed numbers of features in omics association studies. Reviewed

    Kawabata T, Emoto R, Nishino J, Takahashi K, Matsui S

    Stat Med   Vol. 38 ( 16 ) page: 2956-2971   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/sim.8150.

  60. Two-stage analysis for selecting fixed numbers of features in omics association studies

    Kawabata, T; Emoto, R; Nishino, J; Takahashi, K; Matsui, S

    STATISTICS IN MEDICINE   Vol. 38 ( 16 ) page: 2956 - 2971   2019.7

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  61. Steeper Macular Curvature in Eyes With Non-Highly Myopic Retinitis Pigmentosa. Reviewed

    Komori S, Ueno S, Ito Y, Sayo A, Meinert M, Kominami T, Inooka D, Kitagawa M, Nishida K, Takahashi K, Matsui S, Terasaki H

    Invest Ophthalmol Vis Sci   Vol. 60 ( 8 ) page: 3135-3141   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1167/iovs.19-27334.

  62. Statistical testing strategies for assessing treatment efficacy and marker accuracy in phase III trials Reviewed

    Nonaka T, Igeta M, Matsui S

    Pharm Stat   Vol. 18 ( 4 ) page: 459-475   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/pst.1937.

  63. External validation of a risk classification at the emergency department of post-cardiac arrest syndrome patients undergoing targeted temperature management. Reviewed

    Nishikimi M, Ogura T, Nishida K, Takahashi K, Nakamura M, Matsui S, Matsuda N, Iwami T

    Resuscitation   ( 140 ) page: 135-141   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.resuscitation.2019.05.028.

  64. External validation of a risk classification at the emergency department of post-cardiac arrest syndrome patients undergoing targeted temperature management

    Nishikimi, M; Ogura, T; Nishida, K; Takahashi, K; Nakamura, M; Matsui, S; Matsuda, N; Iwami, T

    RESUSCITATION   Vol. 140   page: 135 - 141   2019.7

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  65. Steeper Macular Curvature in Eyes With Non-Highly Myopic Retinitis Pigmentosa

    Komori, S; Ueno, S; Ito, Y; Sayo, A; Meinert, M; Kominami, T; Inooka, D; Kitagawa, M; Nishida, K; Takahashi, K; Matsui, S; Terasaki, H

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   Vol. 60 ( 8 ) page: 3135 - 3141   2019.7

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  66. Statistical testing strategies for assessing treatment efficacy and marker accuracy in phase III trials

    Nonaka, T; Igeta, M; Matsui, S

    PHARMACEUTICAL STATISTICS   Vol. 18 ( 4 ) page: 459 - 475   2019.7

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  67. Novel multi-gene classifier for prediction of relapse-free survival after FU-based adjuvant chemotherapy for stage III colon cancer: A biomarker study of the ACTS-C trial, a randomized controlled study

    Ishikawa, T; Murotani, K; Ishiguro, M; Nakatani, E; Uetake, H; Matsui, S; Sugihara, K

    CANCER RESEARCH   Vol. 79 ( 13 )   2019.7

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  68. Maximum norepinephrine dosage within 24 hours as an indicator of refractory septic shock: A retrospective study.

    Kasugai D, Hirakawa A, Ozaki M, Nishida K, Ikeda T, Takahashi K, Matsui S, Uenishi N

    J Intensive Care Med     page: 885066619860736   2019.6

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    DOI: 10.1177/0885066619860736.

  69. Timing of administration of epinephrine predicts the responsiveness to epinephrine in norepinephrine-refractory septic shock: a retrospective study. Reviewed

    Kasugai D, Nishikimi M, Nishida K, Higashi M, Yamamoto T, Numaguchi A, Takahashi K, Matsui S, Matsuda N

    J Intensive Care   Vol. 7   page: 20   2019.4

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    DOI: 10.1186/s40560-019-0377-1.

  70. Timing of administration of epinephrine predicts the responsiveness to epinephrine in norepinephrine-refractory septic shock: a retrospective study

    Kasugai, D; Nishikimi, M; Nishida, K; Higashi, M; Yamamoto, T; Numaguchi, A; Takahashi, K; Matsui, S; Matsuda, N

    JOURNAL OF INTENSIVE CARE   Vol. 7   page: 20   2019.4

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  71. Hokuriku Liver Study Group. Development of novel diagnostic system for pancreatic cancer, including early stages, measuring mRNA of whole blood cells. Reviewed

    Sakai Y, Honda M, Matsui S, Komori O, Murayama T, Fujiwara T, Mizuno M, Imai Y, Yoshimura K, Nasti A, Wada T, Iida N, Kitahara M, Horii R, Toshikatsu T, Nishikawa M, Okafuji H, Mizukoshi E, Yamashita T, Yamashita T, Arai K, Kitamura K, Kawaguchi K, Takatori H, Shimakami T, Terashima T, Hayashi T, Nio K, Kaneko S

    Cancer Sci   Vol. 110 ( 4 ) page: 1364-1388   2019.4

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    DOI: 10.1111/cas.13971.

  72. Development of novel diagnostic system for pancreatic cancer, including early stages, measuring mRNA of whole blood cells

    Sakai, Y; Honda, M; Matsui, S; Komori, O; Murayama, T; Fujiwara, T; Mizuno, M; Imai, Y; Yoshimura, K; Nasti, A; Wada, T; Iida, N; Kitahara, M; Horii, R; Toshikatsu, T; Nishikawa, M; Okafuji, H; Mizukoshi, E; Yamashita, T; Yamashita, T; Arai, K; Kitamura, K; Kawaguchi, K; Takatori, H; Shimakami, T; Terashima, T; Hayashi, T; Nio, K; Kaneko, S

    CANCER SCIENCE   Vol. 110 ( 4 ) page: 1364 - 1388   2019.4

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  73. [Na+] Increases in body fluids sensed by central Nax induce sympathetically mediated blood pressure elevations via H+-dependent activation of ASIC1a Reviewed

    Nomura K, Hiyama TY, Sakuta H, Matsuda T, Lin CH, Kobayashi K, Kobayashi K, Kuwaki T, Takahashi K, Matsui S, Noda M

    Neuron   Vol. 101 ( 1 ) page: 60 - +   2019.1

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    DOI: 10.1016/j.neuron.2018.11.017

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  74. Exploring predictive biomarkers from clinical genome-wide association studies via multidimensional hierarchical mixture models. Reviewed

    Otani T, Noma H, Sugasawa S, Kuchiba A, Goto A, Yamaji T, Kochi Y, Iwasaki M, Matsui S, Tsunoda T.

    European Journal of Human Genetics   Vol. 27 ( 1 ) page: 140 - 149   2019.1

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    DOI: 10.1038/s41431-018-0251-y

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  75. compound.Cox: univariate feature selection and compound covariate for predicting survival. Reviewed

    Emura T, Matsui S, Chen HY.

    Computer Methods and Programs in Biomedicine   Vol. 168 ( 1 ) page: 21 - 37   2019.1

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    DOI: 10.1016/j.cmpb.2018.10.020

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  76. A Model-Based Framework for Voxel and Region Level Inferences in Neuroimaging Disease-Association Studies

    Emoto, R; Kawaguchi, A; Otani, T; Matsui, S

    16TH INTERNATIONAL CONFERENCE ON INFORMATION TECHNOLOGY-NEW GENERATIONS (ITNG 2019)   Vol. 800   page: 367 - 372   2019

  77. Designs for Early-Phase Immunotherapeutic Agent Trials

    Daimon, T; Hirakawa, A; Matsui, S

    DOSE-FINDING DESIGNS FOR EARLY-PHASE CANCER CLINICAL TRIALS: A BRIEF GUIDEBOOK TO THEORY AND PRACTICE     page: 121 - 133   2019

  78. Designs Considering Toxicity and Efficacy

    Daimon, T; Hirakawa, A; Matsui, S

    DOSE-FINDING DESIGNS FOR EARLY-PHASE CANCER CLINICAL TRIALS: A BRIEF GUIDEBOOK TO THEORY AND PRACTICE     page: 95 - 120   2019

  79. Application of the Multi-Dimensional Hierarchical Mixture Model to Cross-Disorder Genome-Wide Association Studies

    Otani, T; Nishino, J; Emoto, R; Matsui, S

    16TH INTERNATIONAL CONFERENCE ON INFORMATION TECHNOLOGY-NEW GENERATIONS (ITNG 2019)   Vol. 800   page: 361 - 366   2019

  80. A New Scoring System for Predicting Adverse Events in Hospitalized Patients with Community-Onset Pneumonia

    Sakakibara, T; Shindo, Y; Takahashi, K; Kobayashi, D; Okumura, J; Sano, M; Murakami, Y; Thabet, N; Kobayashi, H; Yagi, T; Matsui, S; Saka, H; Hasegawa, Y

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 199   2019

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  81. Dose-Finding Designs for Early-Phase Cancer Clinical Trials A Brief Guidebook to Theory and Practice Preface

    Daimon, T; Hirakawa, A; Matsui, S

    DOSE-FINDING DESIGNS FOR EARLY-PHASE CANCER CLINICAL TRIALS: A BRIEF GUIDEBOOK TO THEORY AND PRACTICE     page: VII - VIII   2019

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  82. Rule-Based Designs Considering Toxicity Alone

    Daimon, T; Hirakawa, A; Matsui, S

    DOSE-FINDING DESIGNS FOR EARLY-PHASE CANCER CLINICAL TRIALS: A BRIEF GUIDEBOOK TO THEORY AND PRACTICE     page: 9 - 32   2019

  83. Model-Based Designs Considering Toxicity Alone

    Daimon, T; Hirakawa, A; Matsui, S

    DOSE-FINDING DESIGNS FOR EARLY-PHASE CANCER CLINICAL TRIALS: A BRIEF GUIDEBOOK TO THEORY AND PRACTICE     page: 33 - 79   2019

  84. Model-Assisted Designs Considering Toxicity Alone

    Daimon, T; Hirakawa, A; Matsui, S

    DOSE-FINDING DESIGNS FOR EARLY-PHASE CANCER CLINICAL TRIALS: A BRIEF GUIDEBOOK TO THEORY AND PRACTICE     page: 81 - 94   2019

  85. Early-Phase Cancer Clinical Trials

    Daimon, T; Hirakawa, A; Matsui, S

    DOSE-FINDING DESIGNS FOR EARLY-PHASE CANCER CLINICAL TRIALS: A BRIEF GUIDEBOOK TO THEORY AND PRACTICE     page: 1 - 8   2019

  86. Power and sample size calculation incorporating misspecifications of the variance function in comparative clinical trials with over-dispersed count data. Reviewed

    Igeta M, Takahashi K, Matsui S

      Vol. 74 ( 4 ) page: 1459 - 1467   2018.12

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    DOI: 10.1111/biom.12878

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  87. Comprehensive Search for Prognostic Biomarkers using PCAWG Data

    Kato, M; Nagai, M; Hasegawa, T; Imoto, S; Matsui, S; Tsunoda, T; Shibata, T

    CANCER SCIENCE   Vol. 109   page: 291 - 291   2018.12

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  88. Sleep, the Missing Link? Reply

    Nishikimi, M; Numaguchi, A; Takahashi, K; Matsui, S; Matsuda, N

    CRITICAL CARE MEDICINE   Vol. 46 ( 12 ) page: E1225 - E1226   2018.12

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  89. Two-stage approach based on zone and dose findings for two-agent combination Phase I/II trials

    Shimamura, F; Hamada, C; Matsui, S; Hirakawa, A

    JOURNAL OF BIOPHARMACEUTICAL STATISTICS   Vol. 28 ( 6 ) page: 1025 - 1037   2018.11

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  90. The authors reply. Reviewed

    Nishikimi M, Numaguchi A, Takahashi K, Matsui S, Matsuda N

    Critical Care Medicine   Vol. 46 ( 10 ) page: E1010 - E1011   2018.10

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    DOI: 10.1097/CCM.0000000000003315

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  91. Prognostic impact of MSI and 18qLOH in stage II colon cancer: A prospective biomarker study in the SACURA trial

    Ishikawa, T; Ishiguro, M; Nakatani, E; Ueno, H; Uetake, H; Murotani, K; Matsui, S; Tomita, N; Shimada, Y; Takahashi, K; Kotake, K; Watanabe, M; Mochizuki, H; Teramukai, S; Sugihara, K

    ANNALS OF ONCOLOGY   Vol. 29   2018.10

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  92. Treatment of patients with sepsis in a closed intensive care unit is associated with improved survival: a nationwide observational study in Japan. Reviewed

    Ogura T, Nakamura Y, Takahashi K, Nishida K, Kobashi D, Matsui S

    Journal of Intensive Care 6   Vol. 6   page: 57   2018.9

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    DOI: 10.1186/s40560-018-0322-8

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  93. Personalized dynamic prediction of death according to tumour progression and high-dimensional genetic factors: Meta-analysis with a joint model. Reviewed

    Emura T, Nakatochi M, Matsui S, Michimae H, Rondeau V

    Statistical Methods in Medical Research   Vol. 27 ( 9 ) page: 2842 - 2858   2018.9

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    DOI: 10.1177/0962280216688032

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  94. Preoperative six-minute walk distance is associated with postoperative cognitive dysfunction. Reviewed

    Hayashi K, Oshima H, Shimizu M, Kobayashi K, Matsui S, Nishida Y, Usui A

    Annals of Thoracic Surgery   Vol. 106 ( 2 ) page: 505 - 512   2018.8

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    DOI: 10.1016/j.athoracsur.2018.03.010

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  95. Re-assessment of multiple testing strategies for more efficient genome-wide association studies. Reviewed

    Otani T, Noma H, Nishino J, Matsui S

    European Journal of Human Genetics   Vol. 26 ( 7 ) page: 1038 - 1048   2018.7

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    DOI: 10.1038/s41431-018-0125-3

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  96. Effect of administration of ramelteon, a melatonin receptor agonist, on the duration of stay in the ICU: A single-center randomized placebo-controlled trial. Reviewed

    Nishikimi M, Numaguchi A, Takahashi K, Miyagawa Y, Matsui K, Higashi M, Makishi G, Matsui S, Matsuda N

    Critical Care Medicine   Vol. 46 ( 7 ) page: 1099 - 1105   2018.7

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    DOI: 10.1097/CCM.0000000000003132

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  97. Differential effect of mild therapeutic hypothermia depending on the findings of hypoxic encephalopathy on early CT images in patients with post-cardiac arrest syndrome. Reviewed

    Nishikimi M, Ogura T, Nishida K, Takahashi K, Fukaya K, Liu K, Nakamura M, Matsui S, Matsuda N

    Resuscitation   Vol. 128   page: 11 - 15   2018.7

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    DOI: 10.1016/j.resuscitation.2018.04.029

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  98. Sample Size for Successful Genome-Wide Association Study of Major Depressive Disorder

    Nishino, J; Ochi, H; Kochi, Y; Tsunoda, T; Matsui, S

    FRONTIERS IN GENETICS   Vol. 9   page: 227   2018.6

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  99. Sample size for successful genome-wide association study of major depressive disorder. Reviewed

    Nishino J, Ochi H, Kochi Y, Tsunoda T, Matsui S.

    Frontiers in Genetics   Vol. 9   page: 227   2018.6

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  100. The current state of therapeutic development for rare cancers in Japan, and proposals for improvement. Reviewed

    Kawai A, Goto T, Shibata T, Tani K, Mizutani S, Nishikawa A, Shibata T, Matsumoto S, Nagata K, Narukawa M, Matsui S, Ando M, Toguchida J, Monden M, Heike T, Kimura S, Ueda R

    Cancer Science   Vol. 109 ( 5 ) page: 1731 - 1737   2018.5

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    DOI: 10.1111/cas.13568

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  101. Mortality in patients with community-onset pneumonia at low risk of drug-resistant pathogens: Impact of -lactam plus macrolide combination therapy

    Okumura, J; Shindo, Y; Takahashi, K; Sano, M; Sugino, Y; Yagi, T; Taniguchi, H; Saka, H; Matsui, S; Hasegawa, Y

    RESPIROLOGY   Vol. 23 ( 5 ) page: 526 - 534   2018.5

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  102. Accuracy of the first interpretation of early brain CT images for predicting the prognosis of post-cardiac arrest syndrome patients at the emergency department. Reviewed

    Nishikimi M, Ogura T, Matsui K, Takahashi K, Fukaya K, Liu K, Morita H, Nakamura M, Matsui S, Matsuda N

    Journal of Intensive Care 6   Vol. 6   page: 26   2018.4

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    DOI: 10.1186/s40560-018-0296-6

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  103. Empirical Bayes estimation of semi-parametric hierarchical mixture models for unbiased characterization of polygenic disease architectures. Reviewed

    Nishino J, Kochi Y, Shigemizu D, Kato M, Ikari K, Ochi H, Noma H, Matsui K, Morizono T, Boroevich K, Tsunoda T, Matsui S

    Frontiers in Genetics   Vol. 9   page: 115   2018.4

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    DOI: 10.3389/fgene.2018.00115

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  104. Biomarker-Stratified Phase III Clinical Trials: Enhancement with a Subgroup-Focused Sequential Design

    Matsui, S; Crowley, J

    CLINICAL CANCER RESEARCH   Vol. 24 ( 5 ) page: 994 - 1001   2018.3

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  105. Multi-subgroup gene screening using semi-parametric hierarchical mixture models and the optimal discovery procedure: Application to a randomized clinical trial in multiple myeloma

    Matsui, S; Noma, H; Qu, PP; Sakai, Y; Matsui, K; Heuck, C; Crowley, J

    BIOMETRICS   Vol. 74 ( 1 ) page: 313 - 320   2018.3

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  106. オミクス研究における検証的解析と探索的解析:多重検定とP値を中心に Reviewed

    松井 茂之

    計量生物学   Vol. 38 ( 2 ) page: 127-139   2018

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  107. A dose-response meta-analysis to coffee consumption and colorectal cancer risk in the Japanese population: Application of a cubic-spline model. Reviewed

    Horisaki K, Takahashi K, Ito H, Matsui S

    Journal of Epidemiology   Vol. 28 ( 12 ) page: 503 - 509   2018

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    DOI: 10.2188/jea.JE20170201

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  108. Global overexpression of divalent metal transporter 1 delays crocidolite-induced mesothelial carcinogenesis in male mice. Reviewed

    Funahashi S, Okazaki Y, Nishiyama T, Ohyoshi H, Yasui H, Nishida K, Matsui S, Toyokuni S

    Free Radical Research   Vol. 52 ( 9 ) page: 1030 - 1039   2018

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    DOI: 10.1080/10715762.2018.1514604

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  109. Immune condition of colorectal cancer patients featured by serum chemokines and gene expressions of CD4+ cells in blood. Reviewed

    Komura T, Yano M, Miyake A, Takabatake H, Miyazawa M, Ogawa N, Seki A, Honda M, Wada T, Matsui S, Kaneko S, Sakai Y.

    Canadian Journal of Gastroenterology and Hepatology   Vol. 2018   page: 7436205   2018

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    DOI: 10.1155/2018/7436205

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  110. Advanced Topics on Dose-Finding Designs

    Hirakawa, A; Sato, H; Daimon, T; Matsui, S

    MODERN DOSE-FINDING DESIGNS FOR CANCER PHASE I TRIALS: DRUG COMBINATIONS AND MOLECULARLY TARGETED AGENTS     page: 81 - 89   2018

  111. Dose Finding in Phase I Cancer Trials

    Hirakawa, A; Sato, H; Daimon, T; Matsui, S

    MODERN DOSE-FINDING DESIGNS FOR CANCER PHASE I TRIALS: DRUG COMBINATIONS AND MOLECULARLY TARGETED AGENTS     page: 1 - 7   2018

  112. Dose Finding for Molecularly Targeted Agents (MTAs)

    Hirakawa, A; Sato, H; Daimon, T; Matsui, S

    MODERN DOSE-FINDING DESIGNS FOR CANCER PHASE I TRIALS: DRUG COMBINATIONS AND MOLECULARLY TARGETED AGENTS     page: 59 - 80   2018

  113. Dose Finding for Joint Assessment of Both Efficacy and Toxicity

    Hirakawa, A; Sato, H; Daimon, T; Matsui, S

    MODERN DOSE-FINDING DESIGNS FOR CANCER PHASE I TRIALS: DRUG COMBINATIONS AND MOLECULARLY TARGETED AGENTS     page: 41 - 58   2018

  114. Dose Finding for a Combination of Two Agents

    Hirakawa, A; Sato, H; Daimon, T; Matsui, S

    MODERN DOSE-FINDING DESIGNS FOR CANCER PHASE I TRIALS: DRUG COMBINATIONS AND MOLECULARLY TARGETED AGENTS     page: 9 - 40   2018

  115. High-Flow Nasal Cannula Therapy for Acute Respiratory Failure in Patients with Interstitial Pneumonia: A Retrospective Observational Study

    Omote, N; Hashimoto, N; Matsuda, N; Nishida, K; Sakamoto, K; Ando, A; Nakahara, Y; Nishikimi, M; Higashi, M; Matsui, S; Hasegawa, Y

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 197   2018

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  116. Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents Preface

    Hirakawa, A; Sato, H; Daimon, T; Matsui, S

    MODERN DOSE-FINDING DESIGNS FOR CANCER PHASE I TRIALS: DRUG COMBINATIONS AND MOLECULARLY TARGETED AGENTS     page: VII - VIII   2018

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  117. Longitudinal study of visual field changes determined by Humphrey Field Analyzer 10-2 in patients with Retinitis Pigmentosa. Reviewed

    Sayo A, Ueno S, Kominami T, Nishida K, Inooka D, Nakanishi A, Yasuda S, Okado S, Takahashi K, Matsui S, Terasaki H.

    Sci Rep   Vol. 7 ( 1 ) page: 16383   2017.11

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    DOI: 10.1038/s41598-017-16640-7

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  118. IMPLICATION OF β-LACTAM PLUS MACROLIDE COMBINATION THERAPY ON MORTALITY IN PATIENTS WITH COMMUNITY-ONSET PNEUMONIA AT LOW RISK FOR DRUG-RESISTANT PATHOGENS

    Okumura, J; Shindo, Y; Sano, M; Sakakibara, T; Matsuda, T; Takahashi, K; Saka, H; Matsui, S; Hasegawa, Y

    RESPIROLOGY   Vol. 22   page: 271 - 271   2017.11

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  119. Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus. Reviewed

    Takagishi M, Sawada M, Ohata S, Asai N, Enomoto A, Takahashi K, Weng L, Ushida K, Ara H, Matsui S, Kaibuchi K, Sawamoto K, Takahashi M

    Cell Rep   Vol. 20 ( 4 ) page: 960 - 972   2017.7

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    DOI: 10.1016/j.celrep.2017.06.089

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  120. An efficient and flexible test for rare variant effects. Reviewed

    Sugasawa S, Noma H, Otani T, Nishino J, Matsui S

    Eur J Hum Genet   Vol. 25 ( 6 ) page: 752 - 757   2017.6

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    DOI: 10.1038/ejhg.2017.43

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  121. A novel scoring system for predicting the neurologic prognosis prior to the initiation of induced hypothermia in cases of post-cardiac arrest syndrome: the CAST score Reviewed

    Nishikimi M, Matsuda N, Matsui K, Takahashi K, Ejima T, Liu K, Ogura T, Higashi M, Umino H, Makishi G, Numaguchi A, Matsushima S, Tokuyama H, Nakamura M, Matsui S

    Scand J Trauma Resusc Emerg Med   Vol. 25 ( 1 ) page: 49   2017.5

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    DOI: 10.1186/s13049-017-0392-y

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  122. Quantifying indirect evidence in network meta-analysis Reviewed

    Noma H, Tanaka S, Matsui S, Cipriani A, Furukawa TA

    Statistics in Medicine   Vol. 36 ( 6 ) page: 917-927   2017.3

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    DOI: 10.1002

  123. Quantifying indirect evidence in network meta-analysis

    Noma, H; Tanaka, S; Matsui, S; Cipriani, A; Furukawa, TA

    STATISTICS IN MEDICINE   Vol. 36 ( 6 ) page: 917 - 927   2017.3

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  124. Correcting estimation bias in randomized clinical trials with a test of treatment-by-biomarker interaction Reviewed

    Toyoizumi K, Matsui S

    Statistics in Biopharmaceutical Research   Vol. 9 ( 2 ) page: 172 - 179   2017

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    DOI: 10.1080/19466315.2016.1255252

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  125. Risk Factors For Severe Adverse Outcomes In Patients With Hospital-Acquired Pneumonia

    Sano, M; Shindo, Y; Okumura, J; Sakakibara, T; Matsuda, T; Yagi, T; Matsui, K; Takahashi, K; Matsui, S; Hasegawa, Y

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 195   2017

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  126. CAST: a new score for early prediction of neurological outcomes after cardiac arrest before therapeutic hypothermia with high accuracy Reviewed

    Nishikimi M, Matsuda N, Matsui K, Takahashi K, Ejima T, Liu K, Ogura T, Higashi M, Umino H, Makishi G, Numaguchi A, Matsushima S, Tokuyama H, Nakamura M, Matsui S

    Intensive Care Med   Vol. 42 ( 12 ) page: 2106-2107   2016.12

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  127. Genome-wide DNA copy-number analysis in ACTS-CC trial of adjuvant chemotherapy for stage III colonic cancer Reviewed

    Ishikawa T, Uetake H, Murotani K, Kobunai T, Ishiguro M, Matsui S, Sugihara K

    Anticancer Res   Vol. 36 ( 3 ) page: 853-860   2016.3

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  128. Association between photoreceptor regeneration and visual acuity following surgery for rhegmatogenous retinal detachment Reviewed

    Kobayashi M, Iwase T, Yamamoto K, Ra E, Murotani K, Matsui S, Terasaki H

    Invest Ophthalmol Vis Sci.   Vol. 57 ( 3 ) page: 889-898   2016.3

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    DOI: 10.1167

  129. A comparative study of adaptive dose-finding designs for phase I oncology trials of combination therapies Reviewed

    Hirakawa A, Wages NA, Sato H, Matsui S

    Statistics in Medicine   Vol. 34 ( 24 ) page: 3194-3213   2015.10

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    DOI: 10.1002/sim.6533

  130. Operative wound-related complications after cranial revascularization surgeries Reviewed

    Takanari K, Araki Y, Okamoto S, Sato H, Yagi S, Toriyama K, Yokoyama K, Murotani K, Matsui S, Wakabayashi T, Kamei Y

    J Neurosurg     2015.7

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    DOI: 10.3171/2014.12.JNS132602

  131. Sex-Related Differences in Ocular Blood Flow of Healthy Subjects Using Laser Speckle Flowgraphy Reviewed

    Yanagida K, Iwase T, Yamamoto K, Ra E, Kaneko H, Murotani K, Matsui S, Terasaki H

    Invest Ophthalmol Vis Sci   Vol. 56 ( 8 ) page: 4880-4890   2015.7

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    DOI: 10.1167/iovs.15-16567

  132. Estimation of treatment effects in all-comers randomized clinical trials with a predictive marker. Biometrics Reviewed

    Choai Y, Matsui S

    Biometrics   Vol. 71 ( 1 ) page: 25-32   2015.3

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    DOI: 10.1111/biom.12253

  133. Idiopathic sudden sensorineural hearing loss in Japan. Reviewed

    Nakashima T, Sato H, Gyo K, Hato N, Yoshida T, Shimono M, Teranishi M, Sone M, Fukunaga Y, Kobashi G, Takahashi K, Matsui S, Ogawa K

    Acta Otolaryngol     page: 1158-63   2014.11

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  134. Clinical Trials Express: fracture risk reduction with denosumab in Japanese postmenopausal women and men with osteoporosis: denosumab fracture intervention randomized placebo controlled trial (DIRECT).

    Nakamura T, Matsumoto T, Sugimoto T, Hosoi T, Miki T, Gorai I, Yoshikawa H, Tanaka Y, Tanaka S, Sone T, Nakano T, Ito M, Matsui S, Yoneda T, Takami H, Watanabe K, Osakabe T, Shiraki M, Fukunaga M

    J Clin Endocrinol Metab     page: 2599-607   2014.7

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  135. Comparison of statistical analysis plans in randomize-all phase III trials with a predictive biomarker.

    Matsui S, Choai Y, Nonaka T

    Clin Cancer Res     page: 2820-30   2014.6

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  136. Response to letter to the editor by Dr Wages et al. Stat Med.

    Hirakawa A, Matsui S

    Stat Med     page: 2159-60   2014.5

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  137. Distinct cancer-specific survival in metastatic prostate cancer patients classified by a panel of single nucleotide polymorphisms of cancer-associated genes.

    Tsuchiya N, Matsui S, Narita S, Kamba T, Mitsuzuka K, Hatakeyama S, Horikawa Y, Inoue T, Saito S, Ohyama C, Arai Y, Ogawa O, Habuchi T

    Genes Cancer     page: 54-60   2013.1

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  138. Genomic biomarkers for personalized medicine: development and validation in clinical studies.

    Matsui S

    Computational and Mathematical Methods in Medicine     page: Article ID: 865980   2013

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  139. Empirical Bayes ranking and selection methods via semiparametric hierarchical mixture models in microarray studies.

    Statistics in Medicine   Vol. 32   page: 1904-1916   2013

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  140. Cancer outlier analysis based on mixture modeling of gene expression data.

    Mori K, Oura T, Noma H, Matsui S

    Computational and Mathematical Methods in Medicine     page: Article ID: 693901   2013

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  141. An empirical Bayes optimal discovery procedure based on semiparametric hierarchical mixture models.

    Noma H, Matsui S

    Computational and Mathematical Methods in Medicine     page: Article ID: 568480   2013

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  142. Nested case control study of proteomic biomarkers for interstitial lung disease in Japanese patients with non-small-cell lung cancer treated with erlotinib: a multicenter phase 4 study (JO21661)

    Atagi S, Katakami N, Yoshioka H, Fukuoka M, Kudoh S, Ogiwara A, Imai M, Ueda M, Matsui S

    Clinical Lung Cancer   Vol. 14   page: 407-417   2013

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  143. Meta-analysis of oro-cecal transit time in fasting subjects

    Kokubo T, Matsui S, Ishiguro M

    Pharmaceutical Research   Vol. 30   page: 402-411   2013

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  144. A dose finding approach based on shrunken predictive probability for combinations of two agents in phase I trials

    Hirakawa A, Hamada C, Matsui S

    Statistics in Medicine   Vol. 32   page: 4515-4525   2013

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  145. Developing and validating continuous genomic signatures in randomized clinical trials for predictive medicine.

    Matsui S, Simon R, Qu P, Shaughnessy J, Barlogie B, Crowley J

    Clinical Cancer Research   Vol. 18   page: 6065-6073   2012

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  146. The optimal discovery procedure in multiple significance testing: an empirical Bayes approach.

    Statistics in Medicine   Vol. 31   page: 165-176   2012

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  147. Endoscopic evaluation of non-steroidal anti-inflammatory drug (NSAID)-induced gastric and duodenal ulcers during prophylaxis with lansoprazole

    Sakaki N, Ashida K, Mizokami Y, Asaka M, Matsui S, Kanto T, Hiraishi H, Hiramatsu N, Sugano K

    Journal of Gastroenterology and Hepatology Research   Vol. 1   page: 260-265   2012

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  148. Study protocol of the SACURA trial: a randomized phase III trial of efficacy and safety of UFT as adjuvant chemotherapy for stage II colon cancer

    Ishiguro M, Mochizuki H, Tomita N, Shimada Y, Takahashi K, Kotake K, Watanabe M, Kanemitsu Y, Ueno H, Ishikawa T, Uetake H, Matsui S, Teramukai S, Sugihara K

    BMC Cancer   Vol. 12   page: 281   2012

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  149. Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm

    Negoro H, Kanematsu A, Doi M, Suadicani SO, Matsuo M, Imamura M, Okinami T, Nishikawa N, Oura T, Matsui S, Seo K, Tainaka M, Urabe S, Kiyokage E, Todo T, Okamura H, Tabata Y, Ogawa O

    Nature Communications   Vol. 3   page: 809   2012

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  150. Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term non-steroidal anti-inflammatory drug (NSAID) therapy: Results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial

    Sugano K, Kontani T, Katsuo S, Takei Y, Sakaki N, Ashida K, Mizokami Y, Asaka M, Matsui S, Kanto T, Soen S, Takeuchi T, Hiraishi H, Hiramatsu N

    Journal of Gastroenterology   Vol. 47   page: 540-552   2012

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  151. Estimation and selection in high-dimensional genomic studies for developing molecular diagnostics.

    Matsui S, Noma H

    Biostatistics   Vol. 12   page: 223-233   2011

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  152. Estimating effect sizes of differentially expressed genes for power and sample size assessments in microarray experiments.

    Matsui S, Noma H

    Biometrics   Vol. 67   page: 1225-1235   2011

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  153. Population pharmacokinetics of pregabalin in healthy subjects and patients with postherpetic neuralgia or diabetic peripheral neuropathy

    Shoji S, Suzuki M, Tomono Y, Bockbrader HN, Matsui S

    British Journal of Clinical Pharmacology   Vol. 72   page: 63-76   2011

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  154. Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term low-dose aspirin therapy: Results of a prospective, multicenter, double-blind, randomized, double-dummy, active-control trial

    Sugano K, Matsumoto Y, Itabashi T, Abe S, Sakaki N, Ashida K, Mizokami Y, Chiba T, Matsui S, Kanto T, Shimada K, Uchiyama S, Uemura N, Hiramatsu N. for the Lansoprazole Ulcer Prevention Study Group (Low-Dose Aspirin Therapy)

    Journal of Gastoroenterogy   Vol. 46   page: 724-735   2011

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  155. Bayesian ranking and selection methods using hierarchical mixture models in microarray studies.

    Biostatistics   Vol. 11   page: 281-289   2010

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  156. Optimality of gene ranking based on univariate P-values for detecting differentially expressed genes

    Noma H, Matsui S

    Japanese Journal of Biometrics   Vol. 31   page: 13-21   2010

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  157. Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profiling

    Matsumura N, Mandai M, Okamoto T, Yamaguchi K, Yamamura S, Oura T, Baba T, Hamanishi J, Kang HS, Matsui S, Mori S, Murphy SK, Konishi I

    Cancer Science   Vol. 101   page: 2658-2663   2010

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  158. Medical mushrooms used for biochemical failure after radical treatment for prostate cancer: An open-label study

    Yoshimura K, Kamoto T, Ogawa O, Matsui S, Tsuchiya N, Tada H, Murata K, Yoshimura K, Habuchi T, Fukushima M

    International Journal of Urology   Vol. 17   page: 548-554   2010

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  159. Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes

    Yamaguchi K, Mandai M, Oura T, Matsumura N, Hamanishi J, Baba T, Matsui S, Murphy SK, Konishi I

    Oncogene   Vol. 29   page: 1741-1752   2010

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  160. Sample size calculations for controlling the distribution of false discovery proportion in microarray experiments.

    Oura T, Matsui S, Kawakami K

    Biostatistics   Vol. 10   page: 694-705   2009

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  161. Sample sizes for a robust ranking and selection of genes in microarray experiments.

    Matsui S, Oura T

    Statistics in Medicine   Vol. 28   page: 2801-2816   2009

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  162. Clustering of significant genes in prognostic studies with microarrays: application to a clinical study for multiple myeloma

    Matsui S, Yamanaka T, Barlogie B, Shaughnessy J, Crowley J

    Statistics in Medicine   Vol. 27   page: 1106-1120   2008

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  163. Sample size calculations based on ranking and selection in microarray experiments.

    Biometrics   Vol. 64   page: 217-226   2008

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  164. Efficacy, toxicity and cost analysis for non-platinum triplet (gemcitabine and vinorelbine followed by docetaxel) vs. platinum-based chemotherapy in IIIB/IV non-small cell lung cancer: Single institution experience

    Tada H, Matsui S, Kawahara M, Hosoe S, Hamada C, Fukushima M

    European Journal of Cancer Care   Vol. 17   page: 120-126   2008

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  165. Long-term probucol treatment prevents secondary cardiovascular events: a cohort study of patients with heterozygous familial hypercholesterolemia in Japan

    Yamashita S, Hbujo H, Arai H, Harada-Shiba M, Matsui S, Fukushima M, Saito Y, Kita T, Matsuzawa Y

    Journal of Atherosclerosis Thrombosis   Vol. 15   page: 292-303   2008

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  166. Overview of the clinical application of regenerative medicine products in Japan

    Tsubouchi M, Matsui S, Banno Y, Kurokawa K, Kawakami K

    Health Policy   Vol. 88   page: 62-72   2008

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  167. Critical issues for effective collaboration between academia and industry in the field of regenerative medicine in Japan

    Tsubouchi M, Morishita R, Tabata Y, Matsui S, Kawakami K

    Regenerative Medicine   Vol. 3   page: 497-504   2008

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  168. Genomic characterization of multiple clinical phenotypes of cancer using multivariate linear regression models.

    Matsui S, Ito M, Nishiyama H, Uno H, Kotani H, Watanabe J, Guilford P, Reeve A, Fukushima M, Ogawa O

    Bioinformatics   Vol. 23   page: 732-738   2007

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  169. P21-activated kinase 1: a new molecular marker for intravesical recurrence after transurethral resection of bladder cancer

    Ito M, Nishiyama H, Kawanishi H, Matsui S, Guilford P, Reeve A, Ogawa O

    Journal of Urology   Vol. 178   page: 1073-1079   2007

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  170. Predicting survival outcomes using subsets of significant genes in prognostic marker studies with microarrays.

    Matsui S

    BMC Bioinformatics   Vol. 7 ( 156 ) page: 1-9   2006

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  171. Reducing false positive findings in statistical analysis of pharmacogenomic biomarker studies using high-throughput technologies

    Matsui S

    Current Drug Safety2006   Vol. 1   page: 135-141   2006

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  172. Lessons from gefitinib-induced interstitial lung disease in Japan and proposal for the prevention of serious drug-induced suffering: Problems in approval, pharmacovigilance, and regulatory decision-making procedures

    Nishimura T, Tada H, Nakagawa M, Teramukai S, Matsui S, Fukushima M

    Pharmacy Practice   Vol. 4   page: 168-178   2006

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  173. Creutzfeldt-Jakob disease and cadaveric dura mater grafts in Japan: an updated analysis of incubation time

    Matsui S, Sadaike T, Hamada C, Fukushima M

    Neuroepidemiology   Vol. 24   page: 22-25   2005

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  174. Sample size calculations for comparative clinical trials with over-dispersed Poisson process data

    Matsui S

    Statistics in Medicine   Vol. 24   page: 1339-1356   2005

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  175. Stratified analysis in randomized trials with noncompliance

    Matsui S

    Biometrics   Vol. 61   page: 816-823   2005

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  176. Prognostic factor analysis for plaque psoriasis

    Sakai R, Matsui S, Fukushima M, Yasuda H, Miyauchi H, Miyachi Y

    Dermatology   Vol. 211   page: 103-106   2005

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  177. Erythropoietin as a retinal angiogenic factor

    Manzoni P, Maestri A, Gomirato G, Takagi H, Watanabe D, Matsui S

    New England Journal of Medicine   Vol. 353   page: 2190-2191   2005

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  178. Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy

    Watanabe D, Suzuma K, Matsui S, Kurimoto M, Kiryu J, Kita M, Suzuma I, Ohashi H, Ojima T, Murakami T, Kobayashi T, Masuda S, Nagao M, Yoshimura N, Takagi H

    New England Journal of Medicine   Vol. 353   page: 782-792   2005

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  179. Analysis of times to repeated events in two-arm randomized trials with noncompliance and early withdrawal Reviewed

    Matsui S

    Biometrics   Vol. 60   page: 965-976   2004

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  180. Functional assessment of self-renewal activity of male germline stem cells following cytotoxic damage and serial transplantation.

    Shinohara M, Toyokuni S, Morimoto T, Matsui S, Honjo T, Shinohara T

    Biology of Reproduction   Vol. 68   page: 1801-1807   2003

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  181. 中間解析における頻度論的アプローチ:最近の理論的展開

    松井茂之, 宇野一, 小山暢之

    計量生物学   Vol. 21   page: 87-124   2000

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  182. 中間解析におけるベイズ流アプローチ:最近の理論的展開

    宇野一, 松井茂之, 小山暢之

    計量生物学   Vol. 21   page: 125-149   2000

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  183. Analysis of recurrent events: Application to a clinical trial of colony stimulating factor with the endpoint of febrile neutropenia

    Matsui S, Ohashi Y

    Statistics in Medicine   Vol. 18   page: 2409-2420   1999

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  184. Design of clinical trials for recurrent events with periodic monitoring

    Matsui S, Miyagishi H

    Statistics in Medicine   Vol. 18   page: 3005-3020   1999

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▼display all

Books 17

  1. Biomarker-based phase II and III clinical trials in oncology.

    Matsui S, Igeta M, Toyoizumi K( Role: Joint author)

    CRC Press  2019  ( ISBN:9781138083776

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  2. Survival Analysis with Correlated Endpoints: Joint Frailty-Copula Models

    Emura T, Chen YH, Matsui S, Rondeau V( Role: Joint author)

    Springer  2019  ( ISBN:978-981-13-3516-7

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    Total pages:136   Language:English

  3. Dose-Finding Designs for Early-Phase Cancer Clinical Trials: A Brief Guidebook to Theory and Practice

    Daimon T, Hirakawa A, Matsui S( Role: Joint author)

    Springer  2019  ( ISBN:978-4-431-55585-8

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    Total pages:152   Language:English

  4. Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combination and Molecularly Targeted Agents.

    Hirakawa A, Sato H, Daimon T, Matsui S( Role: Joint author)

    Springer  2018  ( ISBN:978-4-431-55573-5

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    Total pages:89   Language:English

  5. 新版医学統計学ハンドブック

    丹後俊郎,松井茂之( Role: Joint author)

    朝倉書店  2018  ( ISBN:978-4-254-12229-9

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    Total pages:868   Language:Japanese

  6. Frontiers of Biostatistical Methods and Applications in Clinical Oncology.

    Matsui S, Crowley J( Role: Joint author)

    Springer  2017.10 

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  7. Design and Analysis of Clinical Trials for Predictive Medicine

    Matsui S, Buyse M, Simon R( Role: Joint author)

    CRC   2015.3 

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  8. Univariate analysis for gene screening: beyond the multiple testing

    Noma H, Matsui S( Role: Joint author)

    CRC  2015.3 

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  9. Statistical issues in clinical development and validation of genomic signatures

    Matsui S( Role: Sole author)

    CRC  2015.3 

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  10. Phase III all-comers clinical trials with a predictive biomarker

    Matsui S, Choai Y, Nonaka T( Role: Joint author)

    CRC  2015.3 

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  11. Phase I dose-finding designs and their applicability to targeted therapies

    Daimon T, Hirakawa A, Matsui S( Role: Joint author)

    CRC  2015.3 

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  12. Clinical trials for predictive medicine: new paradigms and challenges. In Design and Analysis of Clinical Trials for Predictive Medicine

    Simon R, Matsui S, Buyse M( Role: Joint author)

    CRC  2015.3 

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  13. Developments in Statistical Evaluation of Clinical Trials

    ( Role: Joint author)

    2014 

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  14. Developments in Statistical Evaluation of Clinical Trials

    Matsui S, Nonaka T, Choai Y( Role: Joint author)

    Springer  2014 

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  15. Handbook of Statistics in Clinical Oncology, 3rd edn. (eds JJ. Crowley and A Hoering)

    Matsui S, Noma H( Role: Sole author)

    CRC Press  2012 

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    Language:English

  16. 臨床試験ハンドブック

    松井茂之( Role: Sole author)

    朝倉書店  2006 

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    Language:Japanese

  17. Handbook of Statistics in Clinical Oncology, 2nd edn. (eds J.J. Crowley and D.P. Ankerst)

    Matsui S( Role: Sole author)

    CRC Press  2006 

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▼display all

Presentations 30

  1. AI医療技術の検証に向けて:現状と課題 Invited

    松井茂之

    IBISML  2021.1.18  電子情報通信学会

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    Event date: 2021.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:オンライン   Country:Japan  

  2. 医療健康データサイエンティスト:次代の担い手の育成について Invited

    松井茂之

    統計数理研究所医療健康データ科学研究センターシンポジウム  2020.11.5  統計数理研究所

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    Event date: 2020.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:オンライン  

  3. 重み付き尤度関数を用いた治療効果のバイアス補正

    - 豊泉樹一郎、松井茂之

    2020年度 統計関連学会連合大会  2020.9.12  統計関連学会連合

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  4. 脳画像を用いた疾患関連解析における神経学的,機能的領域を考慮した多重検定

    江本 遼、松井茂之

    2020年度 統計関連学会連合大会  2020.9.12  統計関連学会連合

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  5. Incorporating follow-up lengths in sample size re-estimation to compare over-dispersed count data International conference

    Masataka Igeta, Shigeyuki Matsui

    ISCB 2020  2020.8.25  International Society of Clinical Biostatistics

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    Event date: 2020.8

    Language:English   Presentation type:Poster presentation  

  6. Blinded Sample Size Re-estimation in Comparative Clinical Trials with Over-Dispersed Count Data: Incorporation of Misspecification of the Variance Function. International conference

    Masataka Igeta, Shigeyuki Matsui

    Eastern North American Region International Biometric Society, 2019 Meeting 

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    Event date: 2019.3

    Language:English   Presentation type:Poster presentation  

    Venue:Philadelphia   Country:United States  

  7. Multiple Testing and Estimation of Disease Associations Based on Semi-Parametric Hierarchical Mixture Models, Possibly Incorporating Brain Areas International conference

    Ryo Emoto, Takahiro Otani, Shigeyuki Matsui

    Eastern North American Region International Biometric Society, 2019 Meeting 

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    Event date: 2019.3

    Language:English   Presentation type:Poster presentation  

    Venue:Philadelphia   Country:United States  

  8. 生物・医学分野の新たな展開:データを中心とした拡がり/繋がり Invited

    松井茂之

    2018年度統計関連学会連合大会日本計量生物学会シンポジウム 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京(中央大学)   Country:Japan  

  9. 単変量Cox回帰にもとづく遺伝子選択と複合共変量による生存期間の予測

    江村剛志、 松井 茂之、Hsuan-Yu Chen 

    2018年度統計関連学会連合大会 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京(中央大学)   Country:Japan  

  10. 脳画像を用いた疾患関連解析における効果サイズ推定

    江本 遼, 川口 淳, 松井茂之

    2018年度統計関連学会連合大会 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京(中央大学)   Country:Japan  

  11. Hierarchical Mixture Modeling for Multiple Testing and Effect Size Estimation in Voxel-Level Inference of Neuroimaging Data. International conference

    Ryo Emoto, Atsushi Kawaguchi, Hisako Yoshida, Shigeyuki Matsui.

    Joint Statistical Meeting 2019 

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    Event date: 2018.7 - 2018.8

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Vancouver   Country:Canada  

  12. Bias-Corrected Estimation of Treatment Effects in Biomarker-Based Adaptive Subgroup Analysis: New Approach Based on Randomized Tests with Smooth Rejection Function International conference

    Kiichiro Toyoizumi, Shigeyuki Matsui

    Joint Statistical Meeting 2019 

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    Event date: 2018.7 - 2018.8

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Vancouver   Country:Canada  

  13. A Transfer Learning Method for Multi-Center Prognostic Prediction Analysis. International conference

    Kota Matsui, Kenta Kanamori, Wataru Kumagai, Mitsuaki Nishikimi, Shigeyuki Matsui

    3rd International Workshop on Biomedical Informatics with Optimization and Machine Learning in conjunction with 27th International Joint Conference on Artificial Intelligence 

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    Event date: 2018.7

    Language:English   Presentation type:Oral presentation (general)  

    Venue: Stockholm   Country:Sweden  

  14. Two-Stage Analysis for Selecting Fixed Numbers of Features in Omics Association Studies International conference

    XXIX International Biometric Conference 

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    Event date: 2018.7

    Language:English   Presentation type:Poster presentation  

    Country:Spain  

  15. Phase III Clinical Trial Design for Targeted Therapies with Uncertain Biomarker Evidence: Controversies and Solutions (Keynote). Invited International conference

    Matsui S

    OHSU Cancer Biostatistics Workshop 

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    Event date: 2018.5

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Oregon Health & Science University, Portland   Country:United States  

  16. Omics 研究における検証的解析と探索的解析 Invited

    佐藤 俊哉,三中 信宏,松井茂之,寒水 孝司

    2017 年度統計関連学会連合大会日本計量生物学会シンポジウム 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  17. セミパラメトリック階層混合モデルによる複雑疾患GWASの解析

    西野 穣, 高地 雄太, 重水 大智, 加藤 護, 猪狩 勝則, 越智 秀典, 野間 久史, 松井 孝太, 大谷隆浩, 森園 隆, 松井茂之

    第27回 日本疫学会学術総会 

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    Event date: 2017.1

    Language:Japanese   Presentation type:Poster presentation  

    Venue:甲府市   Country:Japan  

  18. セミパラメトリック階層混合モデルによる複雑疾患の遺伝的構造の推定と集団遺伝学的考察

    西野 穣, 松井茂之

    統計数理研究所公募型共同研究重点テーマ2:次世代への健康科学共通公開研究集会 

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    Event date: 2016.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:立川市   Country:Japan  

  19. Stage III結腸癌におけるDNAコピー数変化と無再発生存期間の関連~ACTS-CC試験のバイオマーカー探索

    石川敏昭,植竹宏之,石黒めぐみ,室谷健太,中谷英仁,小武内尚,松井茂之,杉原健

    第71回日本消化器外科学会総会 

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    Event date: 2016.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:徳島市   Country:Japan  

  20. Cancer Outlier Analysis Based on a Nested Two-Way Clustering International conference

    Oura T, Matsui K, Matsui S

    XXVIIIth International Biometric Conference 

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    Event date: 2016.7

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Victoria   Country:Canada  

  21. A comparison of multiple testing methods for effective strategies in genome-wide association studies International conference

    Otani T, Noma H, Nishino J, Matsui K, Matsui S

    XXVIIIth International Biometric Conference 

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    Event date: 2016.7

    Language:English   Presentation type:Poster presentation  

    Venue:Victoria   Country:Canada  

  22. 予測マーカーと治療の交互作用検定を用いるランダム化臨床試験における治療効果のバイアス補正

    豊泉樹一郎, 松井茂之

    2015年度統計関連学会連合大会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  23. ゲノムワイド関連解析データを用いた複雑疾患の階層混合モデル解析

    西野穣, 高地雄太, 野間久史, 重水大智, 森園隆, 角田達彦, 松井茂之

    2015年度統計関連学会連合大会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  24. Biomarker-based all-comers phase III trials: design issues and solutions International conference

    Matsui S

    The first Pacific Rim Cancer Biostatistics Conference 

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    Event date: 2015.8

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:United States  

  25. Bias-corrected estimation of treatment effects in biomarker-based randomized clinical trials International conference

    Toyoizumi K, Matsui S

    Joint Statistical Meetings 2015 

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    Event date: 2015.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  26. MSI, 18q LOH, and clinicopathological features in stage II sporadic colon cancers: Biomarker study in a Phase III Study of Postoperative Adjuvant Chemotherapy for Stage II Colon Cancer (SACURA trial) International conference

    Ishikawa T, Uetake H, Ishiguro M, Murotani K, Matsui S, Ueno H, Sugihara K, Tomita N, SACURA study group

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    Event date: 2015.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  27. ACTS-CC study group. CT211 biomarker search using gene expression databases in a phase III, controlled clinical trial of postoperative adjuvant chemotherapy for stage III colon cancer (ACTS-CC): correlation between clinicopathological factors and gene expression level International conference

    Uetake H, Ishikawa T, Ishiguro M, Matsui S, Sugihara K, ACTS-CC study group

    American Association for Cancer Research Annual Meeting 2015 

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    Event date: 2015.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  28. MSI, 18qLOH, and clinicopathologicalfeatures in stage II sporadic colon cancers: Biomarker study in a phase III study of postoperative adjuvantchemotherapyfor stage II colon cancer (SACURA trial) International conference

    Ishikawa T, Uetake H, Ishiguro M, Murotani K, Matsui S, Ueno H, Sugihara K, Tomita N, SACURA study group

    American Association for Cancer Research Annual Meeting 2015 

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    Event date: 2015.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  29. 計量生物学の更なる可能性を求めて

    松井茂之

    2014 年度日本計量生物学会賞受賞者講演 

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    Event date: 2015.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  30. Statistical analysis plans in phase III all-comers clinical trials with a predictive biomarker International conference

    Matsui S

    The XXVII International Biometric Conference 

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    Event date: 2014.7

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Italy  

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Works 2

  1. 「臨床試験結果の公開は倫理的、科学的に重要」

    2014

  2. がん第 I 相試験における 2 剤併用療法の用量探索法:最近の展開

    2014

Research Project for Joint Research, Competitive Funding, etc. 1

  1. 医学・医療における臨床・全ゲノム・オミックスのビッグデータ解析に基づく疾患の原因探索・亜病態分類とリスク予測

    2014.10 - 2020.3

    戦略的創造研究推進事業 

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    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 10

  1. Use of deep learning and development of statistical prediction result evaluation methods for the acceleration of personalized medicine

    Grant number:23K11014  2023.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s) 

  2. 個別化医療の適応的臨床研究を支える統計・機械学習法に関する研究

    Grant number:21H04874  2021.4 - 2025.3

    科学研究費助成事業  基盤研究(A)

    松井 茂之, 山田 誠, 星野 崇宏, 三分一 史和, 小森 理

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    Authorship:Principal investigator 

    Grant amount:\41600000 ( Direct Cost: \32000000 、 Indirect Cost:\9600000 )

    個別化医療の臨床研究において診断法の開発と検証を同時に行う適応的アプローチに着目する。具体的には、臨床研究の小標本データを用いた機械学習による診断法開発、及び、探索的解析を踏まえた検証的解析としての統計的推測(選択的推論など)に関する方法・ツールを開発する。併せて、様々な疾患領域での事例研究を重点的に行うことで個別化医療開発の現場に役立つ方法論の構築を試みる。
    前年度に続き、個別化医療の開発における二つのケースを想定して検討を行った。
    ケース1は診断法が所与の場合である。診断マーカーを用いて患者集団を選択した後の治療効果の条件付き推定、選択的推論に関して、前年度開発した無作為化検定に基づく重み付き尤度法の汎用性と解釈性を高めるために、データ駆動的な選択イベントに関する「不確実性」を選択確率として導入した新たな枠組みを構築した。一つの適用例として、中間解析の実施により臨床試験の中止・継続を判定する群逐次デザインを想定した定式化と数値実験を開始した。
    ケース2は診断法が定まっておらず、新規治療法の効果に関する診断法を探索的に開発して患者集団を選択し、同時に治療効果の検証を行うケースである。前年度に続き、治療前の患者特性を表す共変量を用いた特徴量の抽出に関して種々のアプローチから検討を行った。各種画像やオミクスなどの分子データの統合解析に向けてデータ収集と解析基盤を構築し、潜在的特徴量の検出のためのベイズ流階層・潜在構造モデリング、非線形カーネルモデリング等の方法を開発し、性能評価を開始した。一方、研究デザインの工夫による解析効率の向上として、クロスオーバーデータを用いた治療効果特徴量の抽出、治療効果予測解析の方法を開発し、その性能を評価した。併せて、治療効果関数や潜在的結果変数の推定に関して、targeted maximum likelihood estimationや計量経済分野のアプローチの適用可能性についても検討を行った。また、新規テーマとして、ごく小標本のもとで新規治療の安全性評価を行うための能動的レベル集合推定に基づく用量探索法を開発し、既存法との比較を行った。
    以上の方法論研究と平行して、各種がん、院内感染、救急医療などにおける事例研究を実施した。
    初年度に同定した研究テーマの大半で一定以上の進捗が得られている。ケース1、ケース2にともに開発した方法論について論文化可能と思われる複数の成果があがっている。一方で、小標本下において複雑な統計・機械学習の方法を実施する際の実施可能性、安定性の問題が明確となった部分もあり、方法論上の更なる工夫の必要性を感じている。方法論の医学研究事例への適用については、前年度に続き、数多くのテーマが候補にあがっており、こちらについても進捗は順調と考えている。以上より、おおむね順調に進展していると判断する。
    今年度に開発した統計・機械学習の方法については論文化を想定して性能評価を数値実験等により行い、更なる評価・検討を重ねる。ケース1におけるデータ駆動的な選択イベントで条件付けた選択的推論については、汎用性、解釈性を備えた統一的な枠組みを構築できたことで、様々な適応的な試験デザインの変更に対処するための道筋が明確となり、引き続き検討を継続したい。一方、ケース2においては、(小標本下での)治療効果予測に用いる特徴量の有効な検出法の確立が必須であるので、引き続き、様々なアプローチを駆使して検討を継続する。併せて、治療効果予測システムの構築、さらに、システムを構築した同一データを用いての治療効果の検証のための選択的推論についての検討を本格化させる。臨床研究事例への適用については数多くの候補事例が出てきており、適用可能性の見込み、臨床上の重要度等の観点から、優先順序を意識して取り組む予定である。

  3. Development of statistical evaluation method for artificial intelligence and deep learning for personalized medicine

    Grant number:19H01806  2019.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Matsuura Masaaki

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    Authorship:Coinvestigator(s) 

    In this research, data analysis using artificial intelligence and deep learning, which has recently begun to be used in medicine, is becoming widespread in order to realize and accelerate personalized medicine. However, there are criticisms that the analysis content is black box-like as to how the analysis results were derived. Therefore, we conducted research to add an evaluation from a statistical point of view regarding "contribution of each feature of deep learning", and in particular, conducted research on specific problems using various actual data, and based on these experiences. We proposed a simple new method.

  4. Comprehensive research on statistical methodologies and their applications for development of personalized medicine

    Grant number:16H06299  2016.5 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (S)

    Matsui Shigeyuki

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    Authorship:Principal investigator 

    Grant amount:\113750000 ( Direct Cost: \87500000 、 Indirect Cost:\26250000 )

    We have developed statistical and machine learning methods and tools for the clinical development of personalized medicine and conducted many case studies in a wide range of disease fields. By comprehensively covering the main phases for developing personalized medicine, including the development and evaluation of diagnostic markers, evaluation of the efficacy of treatments based on diagnostic markers, integration of evidence for personalized medicine based on diagnostic markers, and marker-based decision-making in selecting treatment in medical practice, we have developed statistical and machine learning methodologies that are truly useful for clinical development of personalized medicine.

  5. 個別化医療の開発のための統計的方法論の構築とその実践に関する総合的研究

    2016.4 - 2020.3

    科学研究費補助金  基盤研究(S)

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    Authorship:Principal investigator 

  6. A new framework of discrimination analysis for high-dimensional data based on estimation of data structure

    Grant number:16K12401  2016.4 - 2019.3

    Matsui Shigeyuki

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    Authorship:Principal investigator 

    Grant amount:\3120000 ( Direct Cost: \2400000 、 Indirect Cost:\720000 )

    We developed a novel framework of discrimination analysis of phenotype classes using high-dimensional genomic data in biomedical researches. This framework is based on hierarchical mixture models of the underlying structure on the association between the phonotype and genomic data and is expected to allow for stable discrimination and also for estimation of discrimination accuracy based on the model. We also considered incorporation of disease heterogeneity at the molecular level. One approach is the use of nested mixture models that can identify clusters of genes that are associated with the phonotype in particular subsets of disease patients. We applied the developed methods to real datasets from clinical genomic researches in cancer and other diseases.

  7. 多次元データ解析の新しい枠組み:構造推定と判別解析

    2016.4 - 2018.3

    科学研究費補助金 

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    Authorship:Principal investigator 

  8. Development of statistical methods based on omics data for realizing predictive medicine

    Grant number:15H02671  2015.4 - 2019.3

    Matsuura Masaaki

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    Authorship:Coinvestigator(s) 

    In this study, we developed a novel algorithm to detect unsupervised clusters based on data similarity. A patent application (Japan) was filed in 2016 for a system equipped with this algorithm, and an improved patent was filed in 2017. Furthermore, in 2017 we applied for foreign patents to the United States and China.
    Regarding the method to determine whether the above contents and algorithm are applicable, we made presentations at the XXIXth International Biometric Conference (Barcelona) and the Annual Scientific meeting of the Japan Epidemiological Association in 2017 and 2018. In order to further improve the accuracy of this algorithm, we were able to apply for research including new issues.

  9. 先端医療技術の開発における臨床試験の計画と統計解析に関する研究

    2014.4 - 2018.3

    科学研究費補助金  基盤研究(A)

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    Authorship:Principal investigator 

  10. Statistical methodology for stabilizing of the genome-omics data analysis

    Grant number:25280008  2013.4 - 2018.3

    Egichi Shinto

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    Authorship:Coinvestigator(s) 

    In genome and omics data analysis we aimed at exploiting new statistical methods to challenge a difficult aspect caused by high-dimensional small-sample observations. In particular, we have proposed and published statistical methods and practical algorithms for prediction for treatment effect and prognosis based on genome and omics data beyond existing methods. In major contributions the subsampling replication method for a gene ranking was presented for a stable ranking, and a new modeling, called quasi-linear model, was proposed to incorporate different linear predictors into an integrated predictor connecting by a generalized mean.

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Teaching Experience (On-campus) 8

  1. 社会医学

    2020

  2. 臨床統計学・レギュラトリーサイエンス

    2020

  3. 生物統計学実験研究

    2020

  4. 生物統計学セミナー

    2020

  5. 応用統計学

    2020

  6. 医薬統合プログラム

    2020

  7. 医科学セミナー・医科学実験研究

    2020

  8. 医学入門

    2020

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Social Contribution 1

  1. 日本医薬品医療機器総合機構専門委員

Media Coverage 2

  1. ワクチン治験の簡略化 残る課題 Newspaper, magazine

    朝日新聞  2021.11

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    Author:Other 

  2. 国産ワクチンの壁、治験方法変更で突破目指す 国内企業も準備 Newspaper, magazine

    朝日新聞  2021.9

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    Author:Other 

Academic Activities 8

  1. 日本計量生物学会会長

    Role(s):Planning, management, etc.

    2020.1 - 2022.12

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  2. 統計関連学会連合理事

    Role(s):Planning, management, etc.

    2020.1 - 2020.12

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    Type:Academic society, research group, etc. 

  3. Current Drug Safety

    Role(s):Planning, management, etc.

    2020.1 - 2020.12

  4. Annals of Oncology Editorial Board

    Role(s):Planning, management, etc.

    2020.1 - 2020.12

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    Type:Academic society, research group, etc. 

  5. 日本メディカルAI学会 評議員

    Role(s):Planning, management, etc.

    2020.1 - 2020.12

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  6. 日本統計学会JSS-Springer 編集委員

    Role(s):Planning, management, etc.

    2020.1 - 2020.12

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  7. 日本統計学会 JJSD支援委員

    Role(s):Planning, management, etc.

    2020.1 - 2020.12

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    Type:Academic society, research group, etc. 

  8. Japanese Journal of Statistics and Data Science, Coordinating Editor

    Role(s):Planning, management, etc.

    2020.1 - 2020.12

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