Organization
Institute of Transformative Bio-Molecules Designated associate professor
Graduate School
Graduate School of Science
Title
Designated associate professor
Contact information
SATO Ayato
Degree 1
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博士（理学） （ 2005.7 名古屋大学 ）
Research Interests 2
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ケミカルバイオロジー
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有機合成化学
Current Research Project and SDGs 2
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薬剤耐性を克服する分子探索
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植物の生物ストレス/非生物的ストレスを制御する分子探索
Research History 1
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Nagoya University Institute of Transformative Bio-Molecules
2014.1
Papers 14
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Antihypertensive drug valsartan as a novel BDK inhibitor
Kitaura Yasuyuki, Shindo Daichi, Ogawa Tatsuya, Sato Ayato, Shimomura Yoshiharu
PHARMACOLOGICAL RESEARCH Vol. 167 2021.5
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Transcriptome Analysis of Arabidopsis thaliana Plants Treated with a New Compound Natolen128, Enhancing Salt Stress Tolerance
Sako Kaori, Ha Chien Van, Matsui Akihiro, Tanaka Maho, Sato Ayato, Seki Motoaki
PLANTS-BASEL Vol. 10 ( 5 ) 2021.5
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Identification of a Devernalization Inducer by Chemical Screening Approaches in Arabidopsis thaliana
Shirakawa Makoto, Morisaki Yukaho, Gan Eng-Seng, Sato Ayato, Ito Toshiro
FRONTIERS IN PLANT SCIENCE Vol. 12 2021.2
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Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock
Kolarski Dusan, Miller Simon, Oshima Tsuyoshi, Nagai Yoshiko, Aoki Yugo, Kobauri Piermichele, Srivastava Ashutosh, Sugiyama Akiko, Amaike Kazuma, Sato Ayato, Tama Florence, Szymanski Wiktor, Feringa Ben L., Itami Kenichiro, Hirota Tsuyoshi
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 143 ( 4 ) page： 2078 - 2087 2021.2
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Identification of the hypertension drug niflumic acid as a glycine receptor inhibitor
Ito Daishi, Kawazoe Yoshinori, Sato Ayato, Uesugi Motonari, Hirata Hiromi
SCIENTIFIC REPORTS Vol. 10 ( 1 ) 2020.8
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Isoform-selective regulation of mammalian cryptochromes
Miller Simon, Son You Lee, Aikawa Yoshiki, Makino Eri, Nagai Yoshiko, Srivastava Ashutosh, Oshima Tsuyoshi, Sugiyama Akiko, Hara Aya, Abe Kazuhiro, Hirata Kunio, Oishi Shinya, Hagihara Shinya, Sato Ayato, Tama Florence, Itami Kenichiro, Kay Steve A., Hatori Megumi, Hirota Tsuyoshi
NATURE CHEMICAL BIOLOGY Vol. 16 ( 6 ) page： 676 - + 2020.6
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Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior
Nakayama Tomoya, Okimura Kousuke, Shen Jiachen, Guh Ying-Jey, Tamai T. Katherine, Shimada Akiko, Minou Souta, Okushi Yuki, Shimmura Tsuyoshi, Furukawa Yuko, Kadofusa Naoya, Sato Ayato, Nishimura Toshiya, Tanaka Minoru, Nakayama Kei, Shiina Nobuyuki, Yamamoto Naoyuki, Loudon Andrew S., Nishiwaki-Ohkawa Taeko, Shinomiya Ai, Nabeshima Toshitaka, Nakane Yusuke, Yoshimura Takashi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 117 ( 17 ) page： 9594 - 9603 2020.4
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Sulfamoyl Heteroarylcarboxylic Acids as Promising Metallo-beta-Lactamase Inhibitors for Controlling Bacterial Carbapenem Resistance
Wachino Jun-ichi, Jin Wanchun, Kimura Kouji, Kurosaki Hiromasa, Sato Ayato, Arakawa Yoshichika
MBIO Vol. 11 ( 2 ) 2020
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3,4-Dibromo-7-Azaindole Modulates Arabidopsis Circadian Clock by Inhibiting Casein Kinase 1 Activity
Ono Azusa, Sato Ayato, Fujimoto Kazuhiro J., Matsuo Hiromi, Yanai Takeshi, Kinoshita Toshinori, Nakamichi Norihito
PLANT AND CELL PHYSIOLOGY Vol. 60 ( 11 ) page： 2360 - 2368 2019.11
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Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock
Uehara Takahiro N., Mizutani Yoshiyuki, Kuwata Keiko, Hirota Tsuyoshi, Sato Ayato, Mizoi Junya, Takao Saori, Matsuo Hiromi, Suzuki Takamasa, Ito Shogo, Saito Ami N., Nishiwaki-Ohkawa Taeko, Yamaguchi-Shinozaki Kazuko, Yoshimura Takashi, Kay Steve A., Itami Kenichiro, Kinoshita Toshinori, Yamaguchi Junichiro, Nakamichi Norihito
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 116 ( 23 ) page： 11528 - 11536 2019.6
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Identification and Characterization of Compounds that Affect Stomatal Movements
Toh Shigeo, Inoue Shinpei, Toda Yosuke, Yuki Takahiro, Suzuki Kyota, Hamamoto Shin, Fukatsu Kohei, Aoki Saya, Uchida Mami, Asai Eri, Uozumi Nobuyuki, Sato Ayato, Kinoshita Toshinori
PLANT AND CELL PHYSIOLOGY Vol. 59 ( 8 ) page： 1568 - 1580 2018.8
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Identification of circadian clock modulators from existing drugs
Tamai T. Katherine, Nakane Yusuke, Ota Wataru, Kobayashi Akane, Ishiguro Masateru, Kadofusa Naoya, Ikegami Keisuke, Yagita Kazuhiro, Shigeyoshi Yasufumi, Sudo Masaki, Nishiwaki-Ohkawa Taeko, Sato Ayato, Yoshimura Takashi
EMBO MOLECULAR MEDICINE Vol. 10 ( 5 ) 2018.5
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Discovery of Shoot Branching Regulator Targeting Strigolactone Receptor DWARF14
Yoshimura Masahiko, Sato Ayato, Kuwata Keiko, Inukai Yoshiaki, Kinoshita Toshinori, Itami Kenichiro, Tsuchiya Yuichiro, Hagihara Shinya
ACS CENTRAL SCIENCE Vol. 4 ( 2 ) page： 230 - 234 2018.2
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Discovery of synthetic small molecules that enhance the number of stomata: C-H functionalization chemistry for plant biology
Ziadi Asraa, Uchida Naoyuki, Kato Hiroe, Hisamatsu Rina, Sato Ayato, Hagihara Shinya, Itami Kenichiro, Torii Keiko U.
CHEMICAL COMMUNICATIONS Vol. 53 ( 69 ) page： 9632 - 9635 2017.9
KAKENHI (Grants-in-Aid for Scientific Research) 4
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園芸作物の繁殖や分子育種に寄与する新奇生理活性物質の探索とケミカルバイオロジー
Grant number：21H02184 2021.4 - 2024.3
科学研究費助成事業 基盤研究(B)
白武 勝裕, 佐藤 綾人
Authorship：Coinvestigator(s)
形質転換作物の作出やゲノム編集作物の作出時に問題となっているカルス化，シュート形成，発根を誘導する化合物，また，果樹・花き・果菜類の苗生産において問題となっている挿し木の発根不良を解決する化合物を，ケミカルライブラリーからハイスループットin vitroスクリーニング法によりスクリーニングする．
そして，その化合物が植物に対してどのような作用機作でカルス化，シュート形成，発根を誘導したのかを，生理活性の鍵となる分子構造の決定と化合物の標的タンパク質の特定，化合物を処理した時のトランスクリプトーム変化とメタボローム変化の統合解析による生体内変化から明らかにする． -
気孔開度調節のシグナル伝達の解明と植物の成長制御
Grant number：20H05687 2020.8 - 2025.3
木下 俊則
Authorship：Coinvestigator(s)
植物の表皮に存在する気孔は、光合成に必要な二酸化炭素の唯一の取り入れ口であり、変動する環境条件に応答してその開度を調節している。これまでの研究により、気孔を構成する孔辺細胞では、光に応答して細胞膜プロトンポンプが活性化され、気孔開口の駆動力を形成することなど、気孔開・閉のシグナル伝達の一端が明らかとなってきたが、詳細な分子機構は未だ不明の部分が多い。本研究では、生理・生化学・遺伝学的手法やケミカルバイオロジーを駆使し、気孔開・閉のシグナル伝達の分子機構を明らかにする。さらに、これらの成果に基づき気孔開度を人為的に制御する技術開発を行い、植物の成長促進や乾燥耐性の付与の技術確立を目指す。
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Analysis of pollen tube guidance factors
Grant number：15H04385 2015.4 - 2019.3
Kanaoka Masahiro
Authorship：Coinvestigator(s)
In this research period, I have analyzed the function of pollen tube attractant proteins and established in vitro pollen tube guidance assay system in novel plant species.
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Chemical library screening to identify novel key regulators of organelle distribution in plants
Grant number：15K14542 2015.4 - 2018.3
SATO YOSHIKATSU
Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)
Proper distribution of organelles is essential for proper cell function in eukaryotic cells. In this study, we performed chemical library screening to identify novel key regulators of organelle distribution in plants. As a result of high-throughput but careful screening design, we obtained 9 candidates from 20,000 chemicals, which can be divided into 4 groups by structure-activity relationships. We focused 1 of these groups and evaluated by time-lapse analysis. Then, we confirmed 5 candidates having common structures. Furthermore, we succeeded to identify the essential and non-essential part from hit compounds and to synthesize the dimer compound having strong effect on organelle distribution. Therefore, we conclude that we could obtain important tools and information to elucidate the basic mechanism of organelle distribution in plants.