Updated on 2021/05/28

写真a

 
NAMBO Masakazu
 
Organization
Nagoya University Institute of Transformative Bio-Molecules Designated associate professor
Title
Designated associate professor
Contact information
メールアドレス
External link

Degree 1

  1. 博士(理学) ( 2011.3   名古屋大学 ) 

Research Interests 5

  1. 分子触媒 アリール化 アリールメタン

  2. 炭素-スルホニル結合活性化

  3. 分子触媒

  4. スルホン

  5. アリールメタン

Research Areas 1

  1. Nanotechnology/Materials / Synthetic organic chemistry  / transition metal catalysis

Current Research Project and SDGs 2

  1. 酸性sp3炭素-水素結合に立脚したアリールメタン類の新規合成法の開発

  2. 有機硫黄化合物をテンプレートとするアリールアルカン類の効率的合成法の開発

Research History 7

  1. Nagoya University   Institute of Transformative Bio-Molecules   Designated associate professor

    2021.4

  2. Nagoya University   Institute of Transformative Bio-Molecules   Designated Associate Professor (Co-PI)

    2021.4

  3. Nagoya University   Institute of Transformative Bio-Molecules   Designated Lecturer (Co-PI)

    2018.4 - 2021.3

  4. 名古屋大学トランスフォーマティブ生命分子研究所 特任助教

    2013.2

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    Country:Japan

  5. Nagoya University   Institute of Transformative Bio-Molecules

    2013.2 - 2018.3

  6. 旭化成イーマテリアルズ株式会社勤務

    2011.4 - 2013.1

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    Country:Japan

  7. 名古屋大学大学院理学研究科物質理学専攻(化学系)博士課程

    2008.4 - 2011.3

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    Country:Japan

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Education 1

  1. Nagoya University   Graduate School, Division of Natural Science

    2008.4 - 2011.3

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    Country: Japan

Professional Memberships 5

  1. 日本化学会

  2. KINKA CHEMICAL SOCIETY

  3. THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY

  4. 日本化学会

  5. THE SOCIETY OF FLUORINE CHEMISTRY

Committee Memberships 2

  1. 名古屋大学理学部   同窓会報編集委員  

    2018.4   

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    Committee type:Other

  2. 名古屋大学理学部   同窓会評議員  

    2013.4   

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    Committee type:Other

Awards 10

  1. Incentive Award in Synthetic Organic Chemistry, Japan

    2020.12   The Society of Synthetic Organic Chemistry, Japan  

  2. 第99春季年会 優秀講演賞(学術)

    2019.5   日本化学会  

    南保 正和

  3. The Chemical Society of Japan, Lecture Award for Young Chemists

    2018.3  

    NAMBO Masakazu

  4. SYNLETT Best Paper Award 2017

    2018.1   Thieme Chemistry  

    NAMBO Masakazu

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    Award type:International academic award (Japan or overseas) 

  5. The 4th ITbM Research Award

    2018.1  

    NAMBO Masakazu

  6. 日本化学会第96春季年会 優秀講演賞(学術)

    2016.5   日本化学会  

    南保正和

  7. 第3回ITbM Research Award

    2016.1   トランスフォーマティブ生命分子研究所  

    南保 正和

  8. 第28回有機合成化学協会研究企画賞(中外製薬)

    2015.2   有機合成化学協会  

    南保 正和

  9. Inoue Research Award for Young Scientists

    2014.2  

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    Country:Japan

  10. 第1回ITbM Research Award

    2013.1   トランスフォーマティブ生命分子研究所  

    南保 正和

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Papers 15

  1. Synthesis of quaternary centres by single electron reduction and alkylation of alkylsulfones Reviewed

    Masakazu Nambo, Yasuyo Tahara, Jacky C.-H. Yim, Daisuke Yokogawa, Cathleen M. Crudden

    Chemical Science     2021

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Royal Society of Chemistry (RSC)  

    <p>A new method for the generation of tertiary radicals through single electron reduction of alkylsulfones promoted by Zn and 1,10-phenanthroline has been developed.</p>

    DOI: 10.1039/d1sc00133g

  2. Alkyltriflones in the Ramberg–Bäcklund Reaction: An Efficient and Modular Synthesis of gem-Difluoroalkenes Reviewed

    Yuuki Maekawa, Masakazu Nambo, Daisuke Yokogawa, Cathleen M. Crudden

    Journal of the American Chemical Society   Vol. 142 ( 37 ) page: 15667 - 15672   2020.9

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    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society ({ACS})  

    DOI: 10.1021/jacs.0c07924

    Web of Science

  3. Synthesis and properties of an Au6 cluster supported by a mixed N-heterocyclic carbene–thiolate ligand Reviewed

    Kirsi Salorinne, Renee W. Y. Man, Paul A. Lummis, Maryam Sabooni Asre Hazer, Sami Malola, Jacky C.-H. Yim, Alex J. Veinot, Wenxia Zhou, Hannu Häkkinen, Masakazu Nambo, Cathleen M. Crudden

    Chemical Communications   Vol. 56 ( 45 ) page: 6102 - 6105   2020.6

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Royal Society of Chemistry ({RSC})  

    DOI: 10.1039/d0cc01482f

    Web of Science

  4. Modular synthesis of α-fluorinated arylmethanes via desulfonylative cross-coupling Reviewed

    Masakazu Nambo, Jacky C.-H. Yim, Luiza B. O. Freitas, Yasuyo Tahara, Zachary T. Ariki, Yuuki Maekawa, Daisuke Yokogawa, Cathleen M. Crudden

    Nature Communications   Vol. 10 ( 1 ) page: 4528   2019.12

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media {LLC}  

    DOI: 10.1038/s41467-019-11758-w

  5. Pyridine-catalyzed desulfonative borylation of benzyl sulfones Reviewed

    Yuuki Maekawa, Zachary T. Ariki, Masakazu Nambo, Cathleen M. Crudden

    Organic & Biomolecular Chemistry   Vol. 17 ( 31 ) page: 7300 - 7303   2019.8

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Royal Society of Chemistry ({RSC})  

    DOI: 10.1039/c9ob01099h

    Web of Science

  6. Copper-catalyzed Desulfonylative Cross-coupling of Benzhydryl Sulfones with Azoles Reviewed

    Yim Jacky C-H, Nambo Masakazu, Tahara Yasuyo, Crudden Cathleen M

    CHEMISTRY LETTERS   Vol. 48 ( 8 ) page: 975 - 977   2019.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1246/cl.190334

    Web of Science

  7. N-heterocyclic carbene-functionalized magic-number gold nanoclusters Reviewed

    Mina R. Narouz, Kimberly M. Osten, Phillip J. Unsworth, Renee W.Y. Man, Kirsi Salorinne, Shinjiro Takano, Ryohei Tomihara, Sami Kaappa, Sami Malola, Cao Thang Dinh, J. Daniel Padmos, Kennedy Ayoo, Patrick J. Garrett, Masakazu Nambo, J. Hugh Horton, Edward H. Sargent, Hannu Häkkinen, Tatsuya Tsukuda, Cathleen M. Crudden

    Nature Chemistry   Vol. 11 ( 5 ) page: 419 - 425   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    © 2019, The Author(s), under exclusive licence to Springer Nature Limited. Magic-number gold nanoclusters are atomically precise nanomaterials that have enabled unprecedented insight into structure–property relationships in nanoscience. Thiolates are the most common ligand, binding to the cluster via a staple motif in which only central gold atoms are in the metallic state. The lack of other strongly bound ligands for nanoclusters with different bonding modes has been a significant limitation in the field. Here, we report a previously unknown ligand for gold(0) nanoclusters—N-heterocyclic carbenes (NHCs)—which feature a robust metal–carbon single bond and impart high stability to the corresponding gold cluster. The addition of a single NHC to gold nanoclusters results in significantly improved stability and catalytic properties in the electrocatalytic reduction of CO 2 . By varying the conditions, nature and number of equivalents of the NHC, predominantly or exclusively monosubstituted NHC-functionalized clusters result. Clusters can also be obtained with up to five NHCs, as a mixture of species.

    DOI: 10.1038/s41557-019-0246-5

    Web of Science

    Scopus

    PubMed

  8. Cu‐Catalyzed Desulfonylative Amination of Benzhydryl Sulfones Reviewed

    Masakazu Nambo, Yasuyo Tahara, Jacky C.‐H. Yim, Cathleen M. Crudden

    Chemistry – A European Journal   Vol. 25 ( 8 ) page: 1923 - 1926   2019.2

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1002/chem.201805638

    Web of Science

  9. Ultrastable Gold Nanoparticles Modified by Bidentate N-Heterocyclic Carbene Ligands Reviewed

    Renee W. Y. Man, Chien-Hung Li, Michael W. A. MacLean, Olena V. Zenkina, Matthew T. Zamora, Lisa N. Saunders, Alexander Rousina-Webb, Masakazu Nambo, Cathleen M. Crudden

    Journal of the American Chemical Society   Vol. 140 ( 5 ) page: 1576 - 1579   2018.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society ({ACS})  

    Highly stable gold nanoparticles (Au NPs) functionalized by bidentate N-heterocyclic carbene (NHC) ligands have been synthesized by top-down and bottom-up approaches. A detailed study of the effect of alkylation, denticity, and method of synthesis has led to the production of NHC-stabilized nanoparticles with higher thermal stability than bi- and tridentate thiol-protected Au NPs and than monodentate NHC-stabilized NPs. Importantly, bidentate NHC-protected NPs also displayed unprecedented stability to external thiol, which has been an unsolved problem to date with all nanoparticles. Thus, multidentate NHC ligands are an important, and as yet unrecognized, step forward for the preparation of high stability nanomaterials.

    DOI: 10.1021/jacs.7b08516

    Scopus

  10. Preparation of Quaternary Centers via Nickel-Catalyzed Suzuki–Miyaura Cross-Coupling of Tertiary Sulfones Reviewed

    Zachary T. Ariki, Yuuki Maekawa, Masakazu Nambo, Cathleen M. Crudden

    Journal of the American Chemical Society   Vol. 140 ( 1 ) page: 78 - 81   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society ({ACS})  

    We describe the development of a nickel-catalyzed Suzuki-Miyaura cross-coupling of tertiary benzylic and allylic sulfones with arylboroxines. A variety of tertiary sulfones, which can easily be prepared via a deprotonation-alkylation route, were reacted to afford symmetric and unsymmetric quaternary products in good yields. We highlight the use of either BrettPhos or Doyle's phosphines as effective ligands for these challenging desulfonative coupling reactions. The utility of this methodology was demonstrated in the concise synthesis of a vitamin D receptor modulator analogue.

    DOI: 10.1021/jacs.7b10855

    Web of Science

    Scopus

  11. Synthesis of Tetraarylmethanes by the Triflic Acid-Promoted Formal Cross-Dehydrogenative Coupling of Triarylmethanes with Arenes Reviewed

    Masakazu Nambo, Jacky C. -H. Yim, Kevin G. Fowler, Cathleen M. Crudden

    SYNLETT   Vol. 28 ( 20 ) page: 2936 - 2940   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:GEORG THIEME VERLAG KG  

    The formal cross-dehydrogenative coupling of triarylmethanes with arenes promoted by triflic acid and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone is described. This method provides a variety of tetraarylmethane derivatives in good to excellent yields from triarylmethanes that can be readily prepared by our previous methods. Control experiments suggest a possible catalytic cycle involving the generation of a trityl cation intermediate followed by nucleophilic addition of the arene.

    DOI: 10.1055/s-0036-1588563

    Web of Science

  12. Pd-Catalyzed Desulfonative Cross-Coupling of Benzylic Sulfone Derivatives with 1,3-Oxazoles Reviewed

    Jacky C.-H. Yim, Masakazu Nambo, Cathleen M. Crudden

    Organic Letters   Vol. 19 ( 14 ) page: 3715 - 3718   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society ({ACS})  

    The Pd-catalyzed desulfonative cross-coupling reaction of benzylic sulfone derivatives with 1,3-oxazoles via a deprotonative pathway has been developed. Broad substrate scope for both sulfone and 1,3-oxazole partners is observed, affording a variety of 1,3-oxazole-containing triarylmethanes. Sulfone partners that are primary benzylic, secondary benzylic, and benzhydryl are all effective. Using this method, the straightforward synthesis of multiply arylated structures has been demonstrated.

    DOI: 10.1021/acs.orglett.7b01510

    Web of Science

  13. Water-Soluble N-Heterocyclic Carbene-Protected Gold Nanoparticles: Size-Controlled Synthesis, Stability, and Optical Properties Reviewed

    Salorinne, Kirsi, Man, Renee W. Y., Li, Chien-Hung, Taki, Masayasu, Nambo, Masakazu, Crudden, Cathleen M.

    Angewandte Chemie-International Edition   Vol. 56 ( 22 ) page: 6198 - 6202   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY-V C H VERLAG GMBH  

    NHC-Au-I complexes were used to prepare stable, water-soluble, NHC-protected gold nanoparticles. The water-soluble, charged nature of the nanoparticles permitted analysis by polyacrylamide gel electrophoresis (PAGE), which showed that the nanoparticles were highly monodisperse, with tunable core diameters between 2.0 and 3.3 nm depending on the synthesis conditions. Temporal, thermal, and chemical stability of the nanoparticles were determined to be high. Treatment with thiols caused etching of the particles after 24 h; however larger plasmonic particles showed greater resistance to thiol treatment. These water-soluble, bio-compatible nanoparticles are promising candidates for use in photoacoustic imaging, with even the smallest nanoparticles giving reliable photoacoustic signals.

    DOI: 10.1002/anie.201701605

    Web of Science

  14. Development of Versatile Sulfone Electrophiles for Suzuki-Miyaura Cross-Coupling Reactions Reviewed

    Nambo, Masakazu, Keske, Eric C., Rygus, Jason P. G., Yim, Jacky C. -H., Crudden, Cathleen M.

    Acs Catalysis   Vol. 7 ( 2 ) page: 1108 - 1112   2017.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AMER CHEMICAL SOC  

    The development of fluorinated sulfone derivatives as versatile electrophiles for Suzuki Miyaura cross-coupling reactions is described. Introducing electron-withdrawing groups on the aryl ring of the sulfone facilitates the Pd-catalyzed activation of C-SO2 bonds. Cross-coupling reactions with fluorinated sulfone electrophiles are reported, leading to a variety of multiply arylated products in good yields. The reactivity of this unusual electrophile is benchmarked versus common electrophiles and its use in iterative cross-couplings for concise synthesis of biologically active molecules is described.

    DOI: 10.1021/acscatal.6b03434

    Web of Science

  15. Modular Synthesis of Triarylmethanes through Palladium-Catalyzed Sequential Arylation of Methyl Phenyl Sulfone Reviewed

    Masakazu Nambo, Cathleen M. Crudden

    Angewandte Chemie International Edition   Vol. 53 ( 3 ) page: 742-746   2014.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Triarylmethanes, which are valuable structures in materials, sensing and pharmaceuticals, have been synthesized starting from methyl phenyl sulfone as an inexpensive and readily available template. The three aryl groups were installed through two sequential palladium-catalyzed C-H arylation reactions, followed by an arylative desulfonation. This method provides a new synthetic approach to multisubstituted triarylmethanes using readily available haloarenes and aryl boronic acids, and is also valuable for the preparation of unexplored triarylmethane-based materials and pharmaceuticals.

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Books 5

  1. スルホンを用いる新しいクロスカップリング反応と応用

    南保正和( Role: Sole author)

    化学と教育, 68巻8号, p344-347.  2020.8 

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    Language:Japanese

  2. 第三級アルキルホウ素化合物の触媒的変換反応

    南保正和( Role: Sole author)

    Organometallic News, Vol.1, p26  2020.3 

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    Language:Japanese

  3. スルホンの特性を活かしたアリールメタン類の迅速合成

    南保 正和( Role: Sole author)

    化学と工業  2018.8 

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    Language:Japanese

  4. SYNLETT Best Paper Award 2017: Synthesis of Tetraarylmethanes by the Triflic Acid-Promoted Formal Cross-Dehydrogenative Coupling of Triarylmethanes with Arenes

    NAMBO Masakazu( Role: Joint author)

    Synform  2018.6 

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    Language:Japanese

  5. Synthesis of New Nano Carbon Materials

    Masakazu Nambo, Kenichiro Itami( Role: Joint author)

    McGraw-Hill Yearbook of Science & Technology  2009 

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    Language:English

Presentations 14

  1. New Transformations of Sulfones inspired by C–H Functionalization Invited

    Masakazu Nambo

    12th CCHF Annual Meeting  2020.9.18 

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    Event date: 2020.9

    Language:English   Presentation type:Oral presentation (invited, special)  

  2. Pd-Catalyzed Suzuki–Miyaura Cross-Coupling of -Fluorinated Benzylic Triflones Invited

    Masakazu Nambo

    Tateshina Conference on Organic Chemistry  2019.11.9 

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    Event date: 2019.11

    Language:English   Presentation type:Poster presentation  

  3. Pd- and Ni-Catalyzed Desulfonylative Cross-Coupling Reactions of Benzylic Sulfone Derivatives International conference

    Masakazu Nambo, Jacky C.-H. Yim, Zachary T. Ariki, Yuuki Maekawa, Cathleen M. Crudden

    28th International Symposium on the Organic Chemistry of Sulfur (ISOCS-28)  2018.8.27 

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    Language:English   Presentation type:Oral presentation (general)  

  4. New Chemical Transformations of Organosulfones through C–SO2 Activation Invited

    NAMBO Masakazu

    2018.3.20 

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    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  5. Modular Synthesis of Multiply-arylated Alkanes through Desulfonylative Cross-Coupling Reactions International conference

    Masakazu Nambo, Jacky C.-H. Yim, Zachary T. Ariki, Yuuki Maekawa, Kevin G. Fowler, Cathleen M. Crudden

    International Symposium on Main Group Chemistry Directed towards Organic Synthesis (MACOS)  2018.8.25 

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    Language:English   Presentation type:Oral presentation (general)  

  6. Modular Synthesis of Multiply-arylated Alkanes through Desulfonylative Cross-Coupling Reactions International conference

    Masakazu Nambo, Jacky C.-H. Yim, Zachary T. Ariki, Yuuki Maekawa, Kevin G. Fowler, Cathleen M. Crudden

    2018.11.1 

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    Language:English   Presentation type:Poster presentation  

  7. Modular Synthesis of Fluorinated Arylmethane Derivatives through Desulfonylative Reactions International conference

    Masakazu Nambo, Yasuyo Tahara, Jacky C.-H. Yim, Luiza B, O. Freitas, Yuuki Maekawa, Zachary T. Ariki, Cathleen M. Crudden

    The 14th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-14)  2018.11.14 

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    Language:English   Presentation type:Poster presentation  

  8. Desulfonylative Transformations of a-Fluorinated Benzylic Sulfones

    NAMBO Masakazu

    2019.3.16 

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    Language:English   Presentation type:Oral presentation (general)  

  9. Cu-Catalyzed Desulfonylative Amination of Benzhydryl Sulfone Derivatives via a Cu-Carbene Intermediate

    Masakazu Nambo, Yasuyo Tahara, Jacky C.-H. Yim, Cathleen M. Crudden

    2018.9.20 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  10. Pd-Catalyzed Arylation of Methyl Sulfone Derivatives via C–SO2 Activation: Mechanistic Studies and Applicatio

    Masakazu Nambo, Kohsuke Usui, Daisuke Yokogawa, Jacky C.-H. Yim, Cathleen M. Crudden

    第64回有機金属化学討論会  2017.9.7 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  11. 古くて新しい炭素–スルホニル結合活性化反応の開発

    南保 正和

    有機金属若手の会  2019.9.13 

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    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  12. Pd-Catalyzed Suzuki–Miyaura Cross-Coupling of a-Fluorinated Benzylic Triflones International conference

    NAMBO Masakazu

    27th International Society of Heterocyclic Chemistry Congress  2019.9.1 

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    Language:English   Presentation type:Poster presentation  

  13. Pd-Catalyzed Suzuki–Miyaura Cross-Coupling of a-Fluorinated Benzylic Triflones

    NAMBO Masakazu

    2019.9.14 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  14. Pd-Catalyzed Desulfonative Cross-Coupling Reactions of Fluorinated Sulfone Derivatives

    Masakazu Nambo, Jacky C.-H. Yim, Cathleen M. Crudden

    2017.11.14 

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    Language:Japanese   Presentation type:Poster presentation  

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Research Project for Joint Research, Competitive Funding, etc. 2

  1. 炭素–水素結合の化学変換のみを基軸とする逐次的アリール化反応の開発と生物活性化合物創製への展開

    2014.10 - 2015.10

    学内共同研究 

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    本研究では、生物活性化合物に頻繁にみられるトリアリールメタン化合物群の直接的合成手法の確立を目的とする。具体的には、メチルスルホン化合物の有する特異な酸性sp3炭素—水素(C–H)結合とスルホニル基の潜在的な脱離基としての特性に着目し、連続的なC–Hアリール化を可能にする新触媒の開発を行う。開発した手法を駆使し、抗癌剤として注目されているトリアリールメタン骨格を有する化合物群の最短工程かつ効率的な合成を達成する。

  2. 多置換アリールメタン類の迅速構築法の開発と生物活性化合物合成への応用

    2013.10 - 2014.10

    学内共同研究 

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    本研究では、生物活性化合物に頻繁にみられるアリールメタン化合物群の一般的合成手法の確立を目的とする。具体的には、電子求引基に置換されたメタン化合物の有する酸性sp3炭素—水素(C–H)結合に着目し、芳香族ハロゲン化物とのC–Hアリール化を可能にする新触媒の開発を行う。さらに開発した手法を連続的な芳香環導入反応へと展開するとともに、甲状腺ホルモンや抗癌剤として注目されている多置換アリールメタン骨格を有する化合物群の最短工程かつ効率的な合成を達成する。メチル基をプラットホームとしてアリール基を自在に導入する手法は生物活性化合物群を構築していく上で強力な合成手法となることは明白であり、本研究の達成によって、生物活性化合物群の迅速供給を可能にするのみならず、分子触媒化学においても新しい指針を示す極めてインパクトの大きな研究に発展すると確信する

KAKENHI (Grants-in-Aid for Scientific Research) 13

  1. スルホニル基の分子設計に基づくラジカル種の自在発生と制御

    Grant number:21K05068  2021.4 - 2024.3

    南保 正和

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

  2. 脂質代謝疾患の克服を指向した新規甲状腺ホルモン誘導体の開発

    2020.10 - 2021.9

    公益財団法人 薬理研究会  研究助成金 

    南保正和

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    Authorship:Principal investigator 

  3. 植物ホルモンフローアトラスの構築

    2019.10 - 2024.3

    国立研究開発法人 科学技術振興機構  多細胞間での時空間的な相互作用の理解を目指した技術・解析基盤の創出 

    土屋雄一郎, 南保正和, 佐藤良勝, 土方優

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    Authorship:Coinvestigator(s) 

  4. 金属-カルベン種の新規発生法の開拓と精密分子変換への応用

    2019.4 - 2021.3

    公益財団法人 立松財団  研究助成金 

    南保正和

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    Authorship:Principal investigator 

  5. 甲状腺ホルモンのβ受容体選択的な新規アゴニストの創製

    2019.4 - 2020.3

    公益財団法人 中冨健康科学振興財団  研究助成金 

    南保 正和

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    Authorship:Principal investigator  Grant type:Competitive

  6. 炭素–スルホニル結合活性化戦略に基づく含窒素化合物の自在合成法の開発

    2018.4 - 2019.3

    公益財団法人 市原国際奨学財団  研究助成金 

    南保 正和

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    Authorship:Principal investigator  Grant type:Competitive

  7. 動的速度論的分割を基盤とする新規不斉クロスカップリング反応の開拓

    2017.4 - 2020.3

    日本学術振興会  若手研究B 

    南保 正和

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    Authorship:Principal investigator  Grant type:Competitive

  8. Development of enantioselective cross-coupling based on dynamic kinetic resolution

    Grant number:17K17805  2017.4 - 2020.3

    Nambo Masakazu

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    We have found the dynamic kinetic asymmetric cross-coupling reactions using organosulfones for the synthesis of enantio-enriched triarylmethane derivatives. During the course of this study, Cu-catalyzed amination of benzhydrylsulfones through the Cu-carbene intermediate and Pd-catalyzed desulfonylative cross-coupling reactions of a-fluorinated benzylsulfones have also been developed.

  9. 多置換メタン類の短工程合成を指向した触媒的炭素-スルホニル結合活性化反応の開発

    2016.4 - 2018.3

    有機合成化学協会  研究企画賞 (中外製薬) 

    南保 正和

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    Authorship:Principal investigator  Grant type:Competitive

  10. アセトニトリル誘導体への逐次的アリール化を基軸とする多置換アリールアルカン類の自在構築法の開発

    2016.4 - 2017.3

    伊藤忠兵衛基金  研究助成金 

    南保 正和

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    Authorship:Principal investigator  Grant type:Competitive

  11. N-heterocyclic carbene-modified gold nanoparticles for biosensing

    Grant number:26288023  2014.4 - 2018.3

    Crudden Cathleen

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

    The goal of this grant was to prepare and test stable gold nanoparticles for potential biosensing applications. We have prepared new gold nanoparticles that were protected by carboxylate-functionalized N-heterocyclic carbenes (NHCs) to be water-souble. The resulting gold particles were stable in the presence of electrolytes and gave photoacoustic signals. In addition, we successfully increased stability of gold nanoparticles against thiols by employing bidentate NHC ligands functionalized with long alkyl chains.

  12. 有機硫黄化合物をテンプレートとするアリールアルカン類の効率的合成法の開発

    2014.4 - 2016.3

    科学研究費補助金  若手研究(B)

    南保 正和

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    Authorship:Principal investigator 

    本研究では、生物活性化合物に頻繁にみられる多置換アリールアルカン化合物群の効率的な合成手法の確立を目的とする。具体的には、スルホニル基の有する電子求引基および脱離基としての潜在的な特性に着目し、逐次的な置換基導入を可能にする新規テンプレート分子の開発と新触媒の開発を行う。また開発した手法を不斉反応へと展開し、エナンチオ選択的な多置換アリールアルカン類の合成を目指す。さらに抗癌剤や甲状腺ホルモンなどの生物活性を有する多置換アリールアルカン類の最短工程かつ実用的な合成を達成する。

  13. 酸性sp3炭素-水素結合に立脚したアリールメタン類の新規合成法の開発

    2013.8 - 2014.3

    科学研究費補助金 

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    Authorship:Principal investigator 

    本研究では、生物活性化合物に頻繁にみられるアリールメタン化合物群の一般的合成手法の確立 を目的とする。具体的には、電子求引基に置換されたメタン化合物の有する酸性 sp3 炭素̶水素 (C–H)結合に着目し、芳香族ハロゲン化物との C–H アリール化を可能にする新触媒の開発を行う。 さらに開発した手法を連続的な芳香環導入反応へと展開するとともに、甲状腺ホルモンや抗癌剤 として注目されている多置換アリールメタン骨格を有する化合物群の最短工程かつ効率的な合成 を達成する。

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Industrial property rights 4

  1. フラーレンの誘導体及びその製造方法

    伊丹健一郎, 南保正和

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    Application no:2009-202034  Date applied:2009.9

    Announcement no:2011-051930 

    Country of applicant:Domestic  

  2. 植物細胞分裂抑制剤

    植田美那子, 南保正和, 栗原大輔, 桑田啓子, 大川妙子

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    Application no:特願2016-028537 

  3. トリアリールメタンの製造方法

    南保 正和, Cathleen M. Crudden

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    Application no:特願PCT/JP2014/078653 

  4. トリ(ヘテロ)アリールアセトニトリルの製造方法

    南保正和, Muhammad Yar, Cathleen M. Crudden

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    Application no:特願PCT/JP2015/84181 

 

Teaching Experience (Off-campus) 2

  1. 理科研究BII

    Aichi University of Education)

  2. 有機化学A

    Aichi University of Education)