Updated on 2022/05/16

写真a

 
KANDA Mitsuro
 
Organization
Graduate School of Medicine Program in Integrated Medicine Musculoskeletal and Cutaneous Medicine Lecturer
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Lecturer
Contact information
メールアドレス

Degree 1

  1. 博士(医学) ( 2010.3   名古屋大学 ) 

Research Interests 5

  1. Surgical oncology

  2. Translational research

  3. Gastric cancer

  4. Esophageal cancer

  5. Biomarker

Research Areas 2

  1. Life Science / Digestive surgery

  2. Life Science / Tumor biology

Current Research Project and SDGs 1

  1. 消化器癌を対象としたトランスレーショナルリサーチ

Research History 5

  1. Nagoya University   Graduate School of Medicine Program in Integrated Medicine Musculoskeletal and Cutaneous Medicine   Lecturer

    2019.5

  2. 名古屋大学大学院医学系研究科 消化器外科学   講師

    2019.5

  3. 名古屋大学医学部附属病院 助教

    2013.4 - 2019.4

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    Country:Japan

  4. 名古屋大学医学部附属病院 病院助教

    2012.9 - 2013.3

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    Country:Japan

  5. Johns Hopkins University, postdoctoral fellow

    2010.9 - 2012.8

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    Country:United States

Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    2007.4 - 2010.3

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    - 2001.3

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    Country: Japan

Professional Memberships 20

  1. 日本外科学会

  2. 日本消化器外科学会

  3. 日本肝臓学会

  4. 日本消化器病学会

  5. 日本胃癌学会

  6. 日本膵臓学会

  7. 日本内視鏡外科学会

  8. 日本癌学会

  9. 日本癌治療学会

  10. 日本消化器癌発生学会

  11. 日本臨床外科学会

  12. American Association for Cancer Research

  13. American Society of Clinical Oncology

  14. American Pancreatic Association

  15. International Association of Pancreatology

  16. European Society of Medical Oncology

  17. Asian-Pacific Hepato-Pancreatro-Biliary Association

  18. 日本食道学会

  19. 日本食道学会

  20. Asian-Pacific Hepato-Pancreatro-Biliary Association

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Committee Memberships 2

  1. 日本胃癌学会   会誌編集委員会  

       

  2. 日本胃癌学会   研究推進委員会  

       

Awards 5

  1. 日本胃癌学会 優秀研究賞

    2017.3  

  2. 日本医師会 医学研究奨励賞

    2016.7  

  3. JSS Young Researcher Award

    2014.4  

  4. JSGS Young Investigator of the Year 2013

    2013.7  

  5. AACR Scholar-in-training Award

    2009.4  

 

Papers 440

  1. Expression of cellular retinoic acid binding protein 1 predicts peritoneal recurrence of gastric cancer. Reviewed

    Sakata K, Kanda M, Shimizu D, Nakamura S, Inokawa Y, Hattori N, Hayashi M, Tanaka C, Nakayama G, Kodera Y

    International journal of oncology   Vol. 60 ( 6 )   2022.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/ijo.2022.5353

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  2. Lysosomal-associated membrane protein family member 5 promotes the metastatic potential of gastric cancer cells Reviewed

    Umeda Shinichi, Kanda Mitsuro, Shimizu Dai, Nakamura Shunsuke, Sawaki Koichi, Inokawa Yoshikuni, Hattori Norifumi, Hayashi Masamichi, Tanaka Chie, Nakayama Goro, Kodera Yasuhiro

    GASTRIC CANCER   Vol. 25 ( 3 ) page: 558 - 572   2022.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10120-022-01284-y

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  3. ASO Visual Abstract: Prognostic Value of a Modified Albumin-Bilirubin Grade Designed for Patients with Esophageal Squamous Cell Carcinoma after Radical Resection. Reviewed

    Shinozuka T, Kanda M, Shimizu D, Tanaka C, Inokawa Y, Hattori N, Hayashi M, Koike M, Kodera Y

    Annals of surgical oncology     2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-022-11784-x

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  4. Prognostic Value of a Modified Albumin-Bilirubin Score Designed for Patients with Esophageal Squamous Cell Carcinoma After Radical Resection Reviewed

    Shinozuka Takahiro, Kanda Mitsuro, Shimizu Dai, Tanaka Chie, Inokawa Yoshikuni, Hattori Norifumi, Hayashi Masamichi, Koike Masahiko, Kodera Yasuhiro

    ANNALS OF SURGICAL ONCOLOGY     2022.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-022-11654-6

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  5. ASO Author Reflections: Optimized Cutoff Value of Albumin-Bilirubin Score to Predict Prognosis of Patients with Esophageal Squamous Cell Carcinoma After Radical Resection Reviewed

    Shinozuka Takahiro, Kanda Mitsuro, Kodera Yasuhiro

    ANNALS OF SURGICAL ONCOLOGY     2022.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-022-11656-4

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  6. Prognostic impact of a microscopic positive margin in patients undergoing gastrectomy for gastric cancer: a propensity score‑matched analysis of a multi‑institutional dataset. Reviewed

    Koki Nakanishi, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Dai Shimizu, Chie Tanaka, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

    Surgery today   Vol. 52 ( 4 ) page: 559 - 566   2022.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    PURPOSE: We analyzed the effect of a microscopic positive margin on survival outcomes after gastrectomy for gastric cancer METHODS: We analyzed a multi-institutional dataset to study patients who underwent gastrectomy with curative intent between 2010 and 2014. We used propensity score matching to strictly balance the patients' oncological features, backgrounds, and postoperative treatment to compare the survival outcomes of those with microscopic positive margins and those with negative margins. RESULTS: Among 3029 patients, 32 (1.1%) had positive margins. After matching, we enrolled 128 patients in this retrospective analysis: 32 with a positive margin and 96 with a negative margin. The recurrence-free survival of the positive-margin group was significantly shorter than that of the negative-margin group (hazard ratio [HR], 1.62, 95% confidence interval, 1.00-2.63, p = 0.0485). Consistent results were observed for patients with pStages I-III disease (HR, 1.65, p = 0.0835), whereas the survival curves overlapped in those with pStage IV disease (HR, 1.29, p = 0.5934). The prevalence of overall recurrence in the positive-margin group was higher than that in the negative-margin group (75% vs 58%, p = 0.0917). This trend was consistent with locoregional recurrence (9% vs 3%) and distant recurrence (69% vs 55%). CONCLUSIONS: The survival of patients after curative gastrectomy for gastric cancer was worse in those with microscopic positive margins than in those with negative margins.

    DOI: 10.1007/s00595-021-02365-8

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  7. ASO Visual Abstract: SLC7A9 as a Potential Biomarker for Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma Reviewed

    Baba Hayato, Kanda Mitsuro, Sawaki Koichi, Nakamura Shunsuke, Ueda Sei, Shimizu Dai, Koike Masahiko, Kodera Yasuhiro, Fujii Tsutomu

    ANNALS OF SURGICAL ONCOLOGY   Vol. 29 ( 4 ) page: 2710 - 2710   2022.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-021-11065-z

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  8. SLC7A9 as a Potential Biomarker for Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma Reviewed

    Baba Hayato, Kanda Mitsuro, Sawaki Koichi, Nakamura Shunsuke, Ueda Sei, Shimizu Dai, Koike Masahiko, Kodera Yasuhiro, Fujii Tsutomu

    ANNALS OF SURGICAL ONCOLOGY   Vol. 29 ( 4 ) page: 2699 - 2709   2022.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-021-11001-1

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  9. Comprehensive Genomic Profiling of Neuroendocrine Carcinomas of the Gastrointestinal System. Reviewed

    Yachida S, Totoki Y, Noë M, Nakatani Y, Horie M, Kawasaki K, Nakamura H, Saito-Adachi M, Suzuki M, Takai E, Hama N, Higuchi R, Hirono S, Shiba S, Kato M, Furukawa E, Arai Y, Rokutan H, Hashimoto T, Mitsunaga S, Kanda M, Tanaka H, Takata S, Shimomura A, Oshima M, Hackeng WM, Okumura T, Okano K, Yamamoto M, Yamaue H, Morizane C, Arihiro K, Furukawa T, Sato T, Kiyono T, Brosens LAA, Wood LD, Hruban RH, Shibata T

    Cancer discovery   Vol. 12 ( 3 ) page: 692 - 711   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/2159-8290.CD-21-0669

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  10. Drain Amylase Concentrations at 3 h After Gastrectomy Enhance Early Prediction of Postoperative Peripancreatic Inflammatory Fluid Collection Reviewed

    Nakanishi Koki, Kanda Mitsuro, Tanaka Chie, Takeda Shigeomi, Tanaka Katsuhito, Shimizu Dai, Inokawa Yoshikuni, Hattori Norifumi, Hayashi Masamichi, Nakayama Goro, Fujiwara Michitaka, Kodera Yasuhiro

    WORLD JOURNAL OF SURGERY   Vol. 46 ( 3 ) page: 648 - 655   2022.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00268-021-06401-z

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  11. A microRNA-based liquid biopsy signature for the early detection of esophageal squamous cell carcinoma: a retrospective, prospective and multicenter study. Reviewed

    Miyoshi J, Zhu Z, Luo A, Toden S, Zhou X, Izumi D, Kanda M, Takayama T, Parker IM, Wang M, Gao F, Zaidi AH, Baba H, Kodera Y, Cui Y, Wang X, Liu Z, Goel A

    Molecular cancer   Vol. 21 ( 1 ) page: 44   2022.2

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    DOI: 10.1186/s12943-022-01507-x

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  12. Diagnostic efficacy of circular RNAs as noninvasive, liquid biopsy biomarkers for early detection of gastric cancer Reviewed

    Roy Souvick, Kanda Mitsuro, Nomura Sachiyo, Zhu Zhongxu, Toiyama Yuji, Taketomi Akinobu, Goldenring James, Baba Hideo, Kodera Yasuhiro, Goel Ajay

    MOLECULAR CANCER   Vol. 21 ( 1 ) page: 42   2022.2

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    DOI: 10.1186/s12943-022-01527-7

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  13. Optimal preoperative multidisciplinary treatment in borderline resectable pancreatic cancer: Results of a dual-center study Reviewed

    Kimura Nana, Yamada Suguru, Takami Hideki, Murotani Kenta, Yoshioka Isaku, Shibuya Kazuto, Sonohara Fuminori, Hoshino Yui, Hirano Katsuhisa, Watanabe Toru, Baba Hayato, Mori Kosuke, Miwa Takeshi, Tanaka Haruyoshi, Kanda Mitsuro, Hayashi Masamichi, Matsui Koshi, Okumura Tomoyuki, Kodera Yasuhiro, Fujii Tsutomu

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 40 ( 4 )   2022.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1200/JCO.2022.40.4_suppl.530

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  14. Preoperative docetaxel, cisplatin, and fluorouracil treatment with pegfilgrastim on day 7 for patients with esophageal cancer: A phase II study Reviewed

    Maeda Osamu, Fukaya Masahide, Koike Masahiko, Miyata Kazushi, Kanda Mitsuro, Nishida Kazuki, Ando Masahiko, Kodera Yasuhiro, Ando Yuichi

    ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY     2022.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ajco.13755

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  15. Platelet isoform of phosphofructokinase accelerates malignant features in breast cancer Reviewed

    Inaishi Takahiro, Shibata Masahiro, Ichikawa Takahiro, Kanda Mitsuro, Hayashi Masamichi, Soeda Ikumi, Takeuchi Dai, Takano Yuko, Tsunoda Nobuyuki, Kodera Yasuhiro, Kikumori Toyone

    ONCOLOGY REPORTS   Vol. 47 ( 1 )   2022.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/or.2021.8220

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  16. Impact of molecular surgical margin analysis on the prediction of pancreatic cancer recurrences after pancreaticoduodenectomy Reviewed

    Sunagawa Yuki, Hayashi Masamichi, Yamada Suguru, Tanabe Hiroshi, Kurimoto Keisuke, Tanaka Nobutake, Sonohara Fuminori, Inokawa Yoshikuni, Takami Hideki, Kanda Mitsuro, Tanaka Chie, Nakayama Goro, Koike Masahiko, Kodera Yasuhiro

    CLINICAL EPIGENETICS   Vol. 13 ( 1 ) page: 172   2021.12

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    DOI: 10.1186/s13148-021-01165-8

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  17. Neoadjuvant docetaxel, oxaliplatin plus S-1 for treating clinical stage III squamous cell carcinoma of the esophagus: Study protocol of an open-label phase II trial Reviewed

    Kanda Mitsuro, Shimizu Dai, Miyata Kazushi, Maeda Osamu, Tanaka Chie, Inokawa Yoshikuni, Hattori Norofumi, Hayashi Masamichi, Ando Masahiko, Kuwatsuka Yachiyo, Murotani Kenta, Nakayama Goro, Koike Masahiko, Ando Yuichi, Ebata Tomoki, Kodera Yasuhiro

    CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS   Vol. 24   page: 100853   2021.12

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    DOI: 10.1016/j.conctc.2021.100853

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  18. Intraperitoneal Chemotherapy as Adjuvant or Perioperative Chemotherapy for Patients with Type 4 Scirrhous Gastric Cancer: PHOENIX-GC2 Trial. Reviewed

    Ishigami H, Tsuji Y, Shinohara H, Kodera Y, Kanda M, Yabusaki H, Ito S, Imano M, Yamashita H, Hidemura A, Yamaguchi H, Fukagawa T, Oba K, Kitayama J, Seto Y

    Journal of clinical medicine   Vol. 10 ( 23 )   2021.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/jcm10235666

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  19. Genomewide Expression Profiling Identifies a Novel miRNA-Based Signature for the Detection of Peritoneal Metastasis in Patients With Gastric Cancer. Reviewed International journal

    Shimura T, Toden S, Kandimalla R, Toiyama Y, Okugawa Y, Kanda M, Baba H, Kodera Y, Kusunoki M, Goel A

    Annals of surgery   Vol. 274 ( 5 ) page: E425 - E434   2021.11

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    OBJECTIVE: This study aimed to conduct a genomewide transcriptomic profiling to develop a microRNA (miRNA)-based signature for the identification of peritoneal metastasis (PM) in patients with gastric cancer (GC). SUMMARY BACKGROUND DATA: Even though PM in patients with GC has long been recognized to associate with poor prognosis, currently there is lack of availability of molecular biomarkers for its robust diagnosis. METHODS: We performed a systematic biomarker discovery by analyzing miRNA expression profiles in primary tumors from GC patients with and without PM, and subsequently validated the expression of candidate miRNA biomarkers in 3 independent clinical cohorts of 354 patients with advanced GC. RESULTS: Five miRNAs (miR-30a-5p, -134-5p, -337-3p, -659-3p, and -3917) were identified during the initial discovery phase; three of which (miR-30a-5p, -659-3p, and -3917) were significantly overexpressed in the primary tumors from PM-positive patients in the testing cohort (P = 0.002, 0.04, and 0.007, respectively), and distinguished patients with versus without peritoneal metastasis with the value of area under the curve (AUC) of 0.82. Furthermore, high expression of these miRNAs also associated with poor prognosis (hazard ratio = 2.18, P = 0.04). The efficacy of the combination miRNA signature was subsequently validated in an independent validation cohort (AUC = 0.74). Finally, our miRNA signature when combined together with the macroscopic Borrmann's type score offered a much superior diagnostic in all 3 cohorts (AUC = 0.87, 0.76, and 0.79, respectively). CONCLUSIONS: We have established an miRNA-based signature that have a potential to identify peritoneal metastasis in GC patients.

    DOI: 10.1097/SLA.0000000000003647

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  20. E-PASS scoring system serves as a predictor of short- and long-term outcomes in gastric cancer surgery Reviewed

    Nakanishi Koki, Kanda Mitsuro, Ito Seiji, Mochizuki Yoshinari, Teramoto Hitoshi, Ishigure Kiyoshi, Murai Toshifumi, Asada Takahiro, Ishiyama Akiharu, Matsushita Hidenobu, Kobayashi Daisuke, Shimizu Dai, Tanaka Chie, Fujiwara Michitaka, Murotani Kenta, Kodera Yasuhiro

    SURGERY TODAY     2021.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00595-021-02394-3

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  21. Synaptotagmin 13 & nbsp;Is Highly Expressed in Estrogen Receptor-Positive Breast Cancer Reviewed

    Ichikawa Takahiro, Shibata Masahiro, Inaishi Takahiro, Soeda Ikumi, Kanda Mitsuro, Hayashi Masamichi, Takano Yuko, Takeuchi Dai, Tsunoda Nobuyuki, Kodera Yasuhiro, Kikumori Toyone

    CURRENT ONCOLOGY   Vol. 28 ( 5 ) page: 4080 - 4092   2021.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/curroncol28050346

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  22. Blockade of CHRNB2 signaling with a therapeutic monoclonal antibody attenuates the aggressiveness of gastric cancer cells. Reviewed International journal

    Mitsuro Kanda, Dai Shimizu, Shunsuke Nakamura, Koichi Sawaki, Shinichi Umeda, Takashi Miwa, Haruyoshi Tanaka, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Chie Tanaka, Goro Nakayama, Yohei Iguchi, Masahisa Katsuno, Yasuhiro Kodera

    Oncogene   Vol. 40 ( 36 ) page: 5495 - 5504   2021.9

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    Here, we evaluated the therapeutic potential of antibodies (Abs) targeting cholinergic receptor nicotinic beta 2 subunit (CHRNB2) in gastric cancer. To investigate the effects of these Abs on malignant phenotypes in vitro and in mouse xenograft models, we generated gene knockouts through genome editing, performed RNA interference-mediated knockdown of gene expression, and ectopically expressed CHRNB2 in gastric cancer cells. The effects of anti-CHRNB2 Abs on the proliferation of cancer cells were evaluated both in vitro and in vivo. We determined the effects of Chrnb2 deficiency on mice and the clinical significance of CHRNB2 expression in gastric cancer clinical specimens. Knockdown of CHRNB2 attenuated gastric cancer cell proliferation, whereas forced overexpression of CHRNB2 increased cell proliferation. Knockout of CHRNB2 significantly influenced cell survival and functions associated with metastasis. The effects of polyclonal Abs targeting the C- and N-termini of CHRNB2 guided the development of anti-CHRNB2 monoclonal Abs that inhibited the growth of gastric cancer cells in vitro and in vivo. Pathway analysis revealed that CHRNB2 interfered with signaling through the PI3K-AKT and JAK-STAT pathways. Chrnb2-deficient mice exhibited normal reproduction, organ functions, and motor functions. CHRNB2 regulates multiple oncological phenotypes associated with metastasis, and blockade of CHRNB2 expression using specific Abs shows promise for controlling metastasis in gastric cancer.

    DOI: 10.1038/s41388-021-01945-9

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  23. Efficacy of Splenectomy for Proximal Gastric Cancer with Greater Curvature Invasion or Type 4 Tumor: a Propensity Score Analysis of a Multi-Institutional Dataset. Reviewed International journal

    Seiji Ito, Mitsuro Kanda, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

    World journal of surgery   Vol. 45 ( 9 ) page: 2840 - 2848   2021.9

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    BACKGROUND: Splenectomy for proximal gastric cancer was found to have no survival benefit in a randomized trial clarifying the role of splenectomy (JCOG0110 study). However, since tumor with invasion to the greater curvature and Type 4 tumor were excluded in JCOG0110, the benefit of splenectomy for these tumors is not known. METHODS: A multicenter dataset of patients with gastric cancer who underwent gastrectomy between 2010 and 2014 was created. From the dataset, 114 eligible patients with proximal advanced gastric cancer with invasion to the greater curvature or Type 4 tumor were enrolled. There were 60 patients in the gastrectomy with splenectomy (Spx) group and 54 patients in the spleen-preserving (Prs) group. To balance the essential variables, propensity score analysis was performed, estimating the propensity score with a logistic regression model. Adjusted overall survival (OS) and adjusted disease-free survival (DFS) were estimated using the inverse probability of treatment weighting (IPTW) method. RESULTS: There were significant differences in age, performance status, comorbidity, macroscopic type, and clinical T stage between the Spx and Prs groups. The model for estimating the propensity score was well adapted (c-statistic: 0.830, 95%CI: 0.754-0.906). Adjusted OS was identical between the two groups (HR = 1.089, 95%CI: 0.759-1.563; p = 0.644). The DFS curve of Prs group was consistently tended to be lower than Spx, but the difference was not significant (HR = 0.813, 95%CI: 0.572-1.156; p = 0.249). CONCLUSIONS: The efficacy of splenectomy was minimal for proximal advanced gastric cancer even with invasion to the greater curvature or Type 4 tumor.

    DOI: 10.1007/s00268-021-06173-6

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  24. Assessment of the Diagnostic Efficiency of a Liquid Biopsy Assay for Early Detection of Gastric Cancer Reviewed

    Izumi Daisuke, Zhu Zhongxu, Chen Yuetong, Toden Shusuke, Huo Xinying, Kanda Mitsuro, Ishimoto Takatsugu, Gu Dongying, Tan Miaomiao, Kodera Yasuhiro, Baba Hideo, Li Wei, Chen Jinfei, Wang Xin, Goel Ajay

    JAMA NETWORK OPEN   Vol. 4 ( 8 ) page: e2121129   2021.8

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    DOI: 10.1001/jamanetworkopen.2021.21129

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  25. A Possible Definition of Oligometastasis in Pancreatic Cancer and Associated Survival Outcomes. Reviewed International journal

    Masaya Yamanaka, Masamichi Hayashi, Suguru Yamada, Fuminori Sonohara, Hideki Takami, Yoshikuni Inokawa, Dai Shimizu, Norifumi Hattori, Mitsuro Kanda, Chie Tanaka, Goro Nakayama, Masahiko Koike, Yasuhiro Kodera

    Anticancer research   Vol. 41 ( 8 ) page: 3933 - 3940   2021.8

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    BACKGROUND: Oligometastatic cancer (OM) is possibly associated with relatively better survival outcomes. We attempted to identify cases in line with this OM concept. PATIENTS AND METHODS: A total of 130 cases with unresectable metastatic pancreatic cancer underwent non-curative surgery from April 2001 to December 2019. Sites of metastasis, clinicopathological information, and surgical outcomes were collected to formulate a better definition of OM. RESULTS: OM criteria were defined as having metastasis to a single organ, few countable lesions and low serum cancer antigen 19-9 level. The median overall survival after non-curative surgery of OM cases was 13.0 months and was significantly better than that of non-OM cases (8.4 months, p=0.003). CONCLUSION: We propose single-organ metastasis of limited tumor volume (H1 or P1/2 by the Japanese Society of Cancer of the Colon and Rectum classification) and low serum cancer antigen 19-9 level (<2,000 U/ml) as new criteria for defining OM pancreatic cancer.

    DOI: 10.21873/anticanres.15189

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  26. Accurate Prediction of Prognosis After Radical Resection of Gastric Cancer by the Modified Systemic Inflammation Score; a Multicenter Dataset Analysis. Reviewed International journal

    Kota Inagaki, Mitsuro Kanda, Koki Nakanishi, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

    World journal of surgery   Vol. 45 ( 8 ) page: 2513 - 2520   2021.8

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    BACKGROUND: The presence of chronic inflammation and nutritional status in cancer patients affects its prognosis. There is a clinical need for a prognostic predictor that is objective and accurate, and that can be easily evaluated by preoperative screening. We evaluated the importance and usefulness of the preoperative modified systemic inflammation score (mSIS) to predict the long-term outcome of patients undergoing curative resection for gastric cancer (GC). METHODS: Of the 3571 patients who underwent curative resection for GC in nine institutions between January 2010 and December 2014, 1764 patients who met the inclusion criteria were included. The mSIS was formulated according to the serum albumin level (ALB) and lymphocyte-to-monocyte ratio (LMR) as follows: mSIS 0 (ALB ≥ 4.0 g/dL and LMR ≥ 3.4), mSIS 1 (ALB < 4.0 g/dL or LMR < 3.4), and mSIS 2 (ALB < 4.0 g/dL and LMR < 3.4). RESULTS: Patients were categorized into preoperative mSIS 0 (n = 955), mSIS 1 (n = 584), and mSIS 2 (n = 225) groups. The overall survival times and the disease-free survival times of patients in preoperative mSIS 0,1 and 2 sequentially shortened (P < 0.0001), and mSIS 1 and 2 were identified as an independent prognostic factor (hazard ratio [HR] 1.35, 95% confidence interval [CI] 1.06-1.272, P = 0.0125 and HR 1.63, 95% CI 1.21-2.19, P = 0.0012). A stepwise increase in the prevalence of hematogenous recurrences was directly proportional to the mSIS. A forest plot revealed that mSIS 0,1 was associated with a greater risk of overall survival in most subgroups. CONCLUSION: Preoperative mSIS can be easily calculated, and it is suggested that it is useful as a prognostic predictor of patients with different disease stages, for stratifying and evaluating clinical outcomes.

    DOI: 10.1007/s00268-021-06138-9

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  27. Update on molecular biomarkers for diagnosis and prediction of prognosis and treatment responses in gastric cancer Reviewed

    Sasahara Masahiro, Kanda Mitsuro, Kodera Yasuhiro

    HISTOLOGY AND HISTOPATHOLOGY   Vol. 36 ( 8 ) page: 817 - 832   2021.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.14670/HH-18-326

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  28. G-protein subunit gamma-4 expression has potential for detection, prediction and therapeutic targeting in liver metastasis of gastric cancer. Reviewed International journal

    Haruyoshi Tanaka, Mitsuro Kanda, Takashi Miwa, Shinichi Umeda, Koichi Sawaki, Chie Tanaka, Daisuke Kobayashi, Masamichi Hayashi, Suguru Yamada, Goro Nakayama, Masahiko Koike, Yasuhiro Kodera

    British journal of cancer   Vol. 125 ( 2 ) page: 220 - 228   2021.7

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    BACKGROUND: The liver is the most common site for haematogenous metastasis of gastric cancer, and liver metastasis is fatal. METHODS: We conducted a transcriptomic analysis between metastatic foci in the liver, primary tumour and adjacent tissues from gastric cancer patients with metastasis limited to the liver. We determined mRNA expression levels in tumour tissues of 300 patients with gastric cancer via quantitative RT-PCR. The oncogenic phenotypes of GNG4 were determined with knockdown, knockout and forced expression experiments. We established and compared subcutaneous and liver metastatic mouse xenograft models of gastric cancer to reveal the roles of GNG4 in tumorigenesis in the liver. RESULTS: GNG4 was upregulated substantially in primary gastric cancer tissues as well as liver metastatic lesions. High levels of GNG4 in primary cancer tissues were associated with short overall survival and the likelihood of liver recurrence. Functional assays revealed that GNG4 promoted cancer cell proliferation, the cell cycle and adhesiveness. Tumour formation by GNG4-knockout cells was moderately reduced in the subcutaneous mouse model and strikingly attenuated in the liver metastasis mouse model. CONCLUSIONS: GNG4 expression may provide better disease monitoring for liver metastasis, and GNG4 may be a novel candidate therapeutic target for liver metastasis.

    DOI: 10.1038/s41416-021-01366-1

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  29. High Serum Uric Acid Levels Could Be a Risk Factor of Hepatocellular Carcinoma Recurrences. Reviewed International journal

    Masamichi Hayashi, Suguru Yamada, Hiroshi Tanabe, Hideki Takami, Yoshikuni Inokawa, Fuminori Sonohara, Dai Shimizu, Norifumi Hattori, Mitsuro Kanda, Chie Tanaka, Goro Nakayama, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera

    Nutrition and cancer   Vol. 73 ( 6 ) page: 996 - 1003   2021.7

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    BACKGROUND: The Apolipoprotein-related MORtality RISk (AMORIS) study in Sweden revealed that serum uric acid (SUA) was significantly associated with hepatobiliary cancer occurrence. However, the association with postoperative hepatocellular carcinoma (HCC) recurrence has not been reported. METHODS: A total of 256 surgically resected HCC patients were included (from January 2003 to December 2017) in this study. Comparisons in terms of clinicopathologic factors and long-term outcomes were made between patients with high SUA (>6.1 mg/dl) at the time of hepatectomy and low SUA. Besides, SUA data at one postoperative year (1POY) of the same cohort were collected and analyzed in the same manner. RESULTS: About 88.8% of tumor relapse sites were the remnant liver. High SUA levels were associated with male and well-differentiated HCCs. Recurrence-free survival (RFS) of high SUA patients was significantly inferior to low SUA patients [median survival time (MST): 22.7 vs. 28.5 mo, P = 0.033], whereas no difference was observed in overall survival (MST: both not reached, P = 0.771). RFS of high SUA patients at 1POY also showed significantly poorer outcomes than low SUA patients (MST: 29.3 vs. 57.0 mo, P = 0.049). CONCLUSIONS: High SUA implies a significant risk factor of activating hepatocarcinogenesis. Keeping the SUA level low may be recommended after HCC resections.

    DOI: 10.1080/01635581.2020.1779758

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  30. Novel prognostic implications of YTH domain family 2 in resected hepatocellular carcinoma. Reviewed International journal

    Nobuhiko Nakagawa, Fuminori Sonohara, Katsuhito Tanaka, Yuki Sunagawa, Yoshikuni Inokawa, Hideki Takami, Masamichi Hayashi, Suguru Yamada, Mitsuro Kanda, Chie Tanaka, Goro Nakayama, Masahiko Koike, Yasuhiro Kodera

    Oncology letters   Vol. 22 ( 1 ) page: 538 - 538   2021.7

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    N6-methyladenosine (m6A), the most abundant internal RNA modification, serves a critical role in cancer development. However, the clinical implications of m6A in hepatocellular carcinoma (HCC) remain unclear. The present study sought to reveal the potential roles of m6A readers, which recognize m6A, in HCC. A total of 177 HCC and paired non-cancerous liver tissues from patients who underwent hepatectomy were analysed using quantitative PCR for the expression of m6A readers: YT521-B homology domain family 1 (YTHDF1) and YT521-B homology domain family 2 (YTHDF2). The expression levels of both YTHDF1 and YTHDF2 were not significantly different between tumour and non-cancerous tissues (P=0.93 and P=0.7, respectively). Analysis of the association between clinical features and m6A reader expression revealed that YTHDF1 expression was associated with formation of capsule (P=0.02), whereas low YTHDF2 expression was associated with septal formation (P=0.02). Furthermore, high YTHDF1 expression and high YTHDF2 expression were significantly associated with shorter recurrence-free survival (RFS) [YTHDF1: Mean survival time (MST), 34.0 vs. 19.0 months, P=0.014; YTHDF2: MST, 30.1 vs. 12.9 months, P=0.0032], whereas YTHDF1 and YTHDF2 expression was not significantly associated with overall survival (OS) (YTHDF1: MST, 99.4 vs. 70.2 months, P=0.74; YTHDF2: MST, 98.4 vs. 64.1 months, P=0.28). According to multivariate analysis, serosal invasion [hazard ratio (HR), 2.39; 95% CI 1.30-4.42; P=0.005), portal vein or hepatic vein invasion (HR, 2.82; 95% CI 1.26-6.28; P=0.01) and YTHDF2 expression in HCC tissues (HR, 1.85; 95% CI 1.09-3.15; P=0.02) were identified as significant independent prognostic factors for RFS. α-fetoprotein (HR, 1.79; 95% CI 1.10-2.92; P=0.02), serosal invasion (HR, 1.99; 95% CI 1.17-3.34; P=0.01) and portal vein or hepatic vein invasion (HR, 3.02; 95% CI 1.38-6.61; P=0.006) were identified as significant independent prognostic factors for OS. In conclusion, the present study revealed that high YTHDF2 expression, an m6A reader, in HCC tissues was associated with cancer recurrence.

    DOI: 10.3892/ol.2021.12799

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  31. BRA膵癌に対する治療戦略 BR-A膵癌に対する集学的治療の術後成績 Reviewed

    猪川 祥邦, 田中 伸孟, 園原 史訓, 高見 秀樹, 林 真路, 神田 光郎, 田中 千恵, 中山 吾郎, 小池 聖彦, 小寺 泰弘

    日本消化器外科学会総会   Vol. 76回   page: O34 - 5   2021.7

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  32. 後期高齢者肝細胞癌における肝切除術の安全性と妥当性に関する検討 Reviewed

    田中 伸孟, 林 真路, 園原 史訓, 猪川 祥邦, 高見 秀樹, 神田 光郎, 田中 千恵, 中山 吾郎, 小池 聖彦, 小寺 泰弘

    日本消化器外科学会総会   Vol. 76回   page: P163 - 7   2021.7

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  33. 膵癌におけるEat me signalの関与 Reviewed

    林 真路, 高見 秀樹, 猪川 祥邦, 園原 史訓, 田中 伸孟, 神田 光郎, 田中 千恵, 中山 吾郎, 小池 聖彦, 小寺 泰弘

    日本消化器外科学会総会   Vol. 76回   page: P186 - 1   2021.7

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  34. miR-23b-3p Plays an Oncogenic Role in Hepatocellular Carcinoma. Reviewed International journal

    Masamichi Hayashi, Suguru Yamada, Keisuke Kurimoto, Hiroshi Tanabe, Sho Hirabayashi, Fuminori Sonohara, Yoshikuni Inokawa, Hideki Takami, Mitsuro Kanda, Chie Tanaka, Goro Nakayama, Masahiko Koike, Yasuhiro Kodera

    Annals of surgical oncology   Vol. 28 ( 6 ) page: 3416 - 3426   2021.6

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    BACKGROUND: Reports show miR-23b to be a cancer-related biomarker in various cancer types. Interestingly, it has a dual role of oncogenic and tumor-suppressive functions, depending on the cancer type. This study focused on the unknown association of miR-23b-3p with hepatocellular carcinoma (HCC). METHODS: Expression of miR-23b-3p was measured in nine HCC cell lines and 125 resected human HCC samples by TaqMan microRNA assays. To detect its downstream target, miR-23b-3p mimic and inhibitor constructs were transfected and analyzed. RESULTS: HepG2, a high miR-23b-3p-expressing cell line, was transfected with a miR-23b-3p inhibitor construct, whereas SK-Hep1, a low miR-23b-3p-expressing cell line, was transfected with a mimic construct. Proliferation of HCC cells was activated by miR-23b-3p overexpression and diminished by its knockdown. Then, 125 clinical HCC samples were examined to measure miR-23b-3p expression. Tumor expression of miR-23b-3p was upregulated in 48 cases (38%) and downregulated in 77 cases (62%). The upregulated cases were correlated with elderly patients (P = 0.015). These patients also showed significantly poor overall survival [hazard ratio (HR), 3.10; 95% conflidence interval (CI), 1.57-6.29; P = 0.001] in a multivariate analysis. Furthermore, mitochondrial metabolism-related genes (MICU3 and AUH) were detected as specific binding targets. CONCLUSION: The study showed that miR-23b-3p functions as an oncogenic microRNA in HCC cell lines. Its overexpression in resected HCC tissues was a significant prognostic factor of overall survival. Both MICU3 and AUH may be candidate gene targets of miR-23b-3p.

    DOI: 10.1245/s10434-020-09283-y

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  35. Short-term outcomes of gastrectomy after neoadjuvant chemotherapy for clinical stage III gastric cancer: propensity score-matched analysis of a multi-institutional database. Reviewed

    Shinichi Umeda, Mitsuro Kanda, Koki Nakanishi, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Dai Shimizu, Daisuke Kobayashi, Chie Tanaka, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

    Surgery today   Vol. 51 ( 5 ) page: 821 - 828   2021.5

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    PURPOSE: Preoperative chemotherapy for gastric cancer may be effective from the standpoint of compliance, although there is insufficient evidence of its efficacy. We analyzed a multicenter database to clarify whether preoperative chemotherapy influenced the short-term outcomes of gastrectomy. METHODS: We analyzed, retrospectively, 3571 patients who underwent gastrectomy between January, 2010 and December, 2014. Patients with clinical stage-III gastric adenocarcinoma were divided into a neoadjuvant chemotherapy (NAC) group and a non-NAC group. We performed propensity-matched comparative analysis to stratify the groups according to age, sex, tumor region, tumor type, preoperative stage, procedure, lymph node dissection, and tumor differentiation. Preoperative blood data, surgical findings, and postoperative complications were analyzed. RESULTS: Analysis of the matched NAC (n = 64) and non-NAC (n = 128) groups revealed that the preoperative values of neutrophils, platelets, and Hb were significantly lower in the NAC group. Blood loss during surgery was significantly higher, surgical times were longer, and the rate of repeat surgery was significantly lower in the NAC group; however, the rates of rehospitalization did not differ between the groups and mortality was 0% in both groups. Postoperative complications were not significantly different between the groups. CONCLUSIONS: NAC did not increase the complication rate of gastrectomy for gastric cancer.

    DOI: 10.1007/s00595-020-02179-0

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  36. 十二指腸肉腫の1例 Reviewed

    山中 雅也, 高見 秀樹, 園原 史訓, 猪川 祥邦, 林 真路, 神田 光郎, 田中 千恵, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本臨床外科学会雑誌   Vol. 82 ( 5 ) page: 1023 - 1023   2021.5

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  37. Transcriptomic Profiling Identifies a Risk Stratification Signature for Predicting Peritoneal Recurrence and Micrometastasis in Gastric Cancer Reviewed

    Lee In-Seob, Lee Heonyi, Hur Hoon, Kanda Mitsuro, Yook Jeong-Hwan, Kim Byung-Sik, Woo Yanghee, Kodera Yasuhiro, Kim Kwangsoo, Goel Ajay

    CLINICAL CANCER RESEARCH   Vol. 27 ( 8 ) page: 2292 - 2300   2021.4

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    DOI: 10.1158/1078-0432.CCR-20-3835

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  38. Hepatic metastasis of gastric cancer is associated with enhanced expression of ethanolamine kinase 2 via the p53-Bcl-2 intrinsic apoptosis pathway. Reviewed International journal

    Takashi Miwa, Mitsuro Kanda, Dai Shimizu, Shinichi Umeda, Koichi Sawaki, Haruyoshi Tanaka, Chie Tanaka, Norifumi Hattori, Masamichi Hayashi, Suguru Yamada, Goro Nakayama, Masahiko Koike, Yasuhiro Kodera

    British journal of cancer   Vol. 124 ( 8 ) page: 1449 - 1460   2021.4

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    BACKGROUND: Gastric cancer (GC) with hepatic metastasis has a poor prognosis. Understanding the molecular mechanisms involved in hepatic metastasis may contribute to the development of sensitive diagnostic biomarkers and novel therapeutic strategies. METHODS: We performed transcriptome analysis of surgically resected specimens from patients with advanced GC. One of the genes identified as specifically associated with hepatic metastasis was selected for detailed analysis. GC cell lines with knockout of the candidate gene were evaluated in vitro and in vivo. Expression of the candidate gene was analysed in GC tissues from 300 patients. RESULTS: Ethanolamine kinase 2 (ETNK2) was differentially upregulated in GC patients with hepatic metastasis. ETNK2 expression was elevated in GC cell lines derived from haematogenous metastases. ETNK2 knockout significantly suppressed proliferation, invasion, and migration; increased apoptosis; reduced Bcl-2 protein expression; and increased phosphorylated p53 expression. In mouse xenograft models, ETNK2 knockout virtually abolished hepatic metastasis. Stratification of GC patients based on ETNK2 mRNA level revealed significant associations between high ETNK2 tumour expression and both hepatic recurrence and worse prognosis. CONCLUSIONS: Upregulation of ETNK2 in GC enhances hepatic metastasis, possibly via dysregulation of p53-Bcl-2-associated apoptosis. ETNK2 expression may serve as a biomarker for predicting hepatic recurrence and a therapeutic target.

    DOI: 10.1038/s41416-021-01271-7

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  39. Peritoneal Lavage Tumor DNA as a Novel Biomarker for Predicting Peritoneal Recurrence in Pancreatic Ductal Adenocarcinoma. Reviewed International journal

    Masaya Suenaga, Tsutomu Fujii, Suguru Yamada, Masamichi Hayashi, Keiko Shinjo, Hideki Takami, Yukiko Niwa, Fuminori Sonohara, Dai Shimizu, Mitsuro Kanda, Daisuke Kobayashi, Chie Tanaka, Goro Nakayama, Masahiko Koike, Michitaka Fujiwara, Yutaka Kondo, Yasuhiro Kodera

    Annals of surgical oncology   Vol. 28 ( 4 ) page: 2277 - 2286   2021.4

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    BACKGROUND: The clinical role of peritoneal lavage cytology (CY) in pancreatic ductal adenocarcinoma (PDAC) remains controversial, partly due to its low sensitivity. This study aimed to develop a new biomarker, defined as peritoneal lavage tumor DNA (ptDNA), using DNAs extracted from peritoneal lavage samples from patients with PDAC. METHODS: Samples were collected intraoperatively from 89 PDAC patients who underwent pancreatectomy between 2012 and 2017. Droplet digital polymerase chain reaction (PCR) was used to measure ptDNA for detection of KRAS mutations. The ptDNA status and clinical characteristics were retrospectively evaluated. RESULTS: Positive ptDNA was found in 41 patients, including all 9 patients positive for CY (CY+) and 32 patients negative for CY (CY-). The mutant allele frequency was significantly higher in the CY+ patients than in the CY- patients. The disease-free survival (DFS) and overall survival (OS) were significantly poorer in the high-ptDNA group than in the low-ptDNA group (median DFS, 11.0 vs. 18.8 months; p = 0.007; median OS, 28.7 vs not reached; p = 0.001). The survival curves of DFS and OS in the CY+ group were almost equal to those in the CY- and high-ptDNA group. In a multivariable analysis, ptDNA was an independent predictive factor for DFS (p = 0.025) and OS (p = 0.047). The estimated cumulative incidence of peritoneal recurrence was 45.5% in the high-ptDNA group. The ptDNA biomarker had a much higher sensitivity for peritoneal recurrence than CY, whereas CY had higher specificity. CONCLUSIONS: As a promising biomarker, ptDNA may predict poor prognosis and peritoneal recurrence in PDAC, resolving the controversy surrounding CY.

    DOI: 10.1245/s10434-020-08990-w

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  40. GAD1の食道扁平上皮癌根治的切除後予後予測バイオマーカーとしての意義 Reviewed

    岸田 貴喜, 神田 光郎, 清水 大, 田中 千恵, 園原 史訓, 猪川 祥邦, 高見 秀樹, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 121回   page: PS - 4   2021.4

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  41. 肝胆膵領域癌におけるサルコペニアの臨床的意義と当教室の周術期対策 Reviewed

    猪川 祥邦, 山田 豪, 横山 幸浩, 薮崎 紀充, 二宮 豪, 田中 伸孟, 園原 史訓, 高見 秀樹, 服部 憲史, 林 真路, 神田 光郎, 田中 千恵, 中山 吾郎, 小池 聖彦, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 121回   page: SF - 3   2021.4

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  42. 片側肝動脈合併切除を伴う膵頭十二指腸切除後の肝動脈血流の評価と早期合併症に関する検討 Reviewed

    鈴木 雄之典, 山田 豪, 猪川 祥邦, 田中 伸孟, 園原 史訓, 高見 秀樹, 服部 憲史, 林 真路, 神田 光郎, 田中 千恵, 中山 吾郎, 小池 聖彦, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 121回   page: PS - 1   2021.4

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  43. 当教室における膵頭十二指腸切除術後出血に対する対策と治療効果の検討 Reviewed

    田中 伸孟, 山田 豪, 園原 史訓, 猪川 祥邦, 高見 秀樹, 服部 憲史, 林 真路, 神田 光郎, 田中 千恵, 中山 吾郎, 小池 聖彦, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 121回   page: SF - 4   2021.4

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  44. 切除肝細胞癌におけるYTH domain family 2の臨床的意義 Reviewed

    中川 暢彦, 園原 史訓, 田中 克仁, 砂川 祐輝, 猪川 祥邦, 高見 秀樹, 林 真路, 山田 豪, 神田 光郎, 田中 千恵, 中山 吾郎, 小池 聖彦, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 121回   page: SF - 7   2021.4

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  45. パンデミック下における外科卒前教育の工夫 Reviewed

    高見 秀樹, 小池 聖彦, 鈴木 雄之典, 栗本 景介, 田中 伸孟, 柴田 雅央, 園原 史訓, 武内 大, 猪川 祥邦, 服部 憲史, 林 真路, 神田 光郎, 田中 知恵, 山田 豪, 中山 吾郎, 菊森 豊根, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 121回   page: SP - 7   2021.4

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  46. ゲノム編集技術を用いたLAMP5遺伝子の胃癌転移巣形成における役割の検討 Reviewed

    梅田 晋一, 神田 光郎, 清水 大, 田中 千恵, 園原 史訓, 高見 秀樹, 猪川 祥邦, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, Fujiwara Michitaka, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 121回   page: SF - 5   2021.4

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  47. UR-M膵癌に対するconversion surgeryの課題 Reviewed

    加藤 吉康, 山田 豪, 田中 伸孟, 園原 史訓, 高見 秀樹, 猪川 祥邦, 林 真路, 服部 憲史, 清水 大, 神田 光郎, 田中 千恵, 中山 吾郎, 小池 聖彦, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 121回   page: SF - 6   2021.4

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  48. 胃癌における組織中RNFT2遺伝子発現と予後の関連性の検討 Reviewed

    笹原 正寛, 神田 光郎, 清水 大, 田中 千恵, 園原 史訓, 高見 秀樹, 猪川 祥邦, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 121回   page: PS - 4   2021.4

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  49. 食道扁平上皮癌術後長期生存例における多重癌発生状況 Reviewed

    清水 大, 小池 聖彦, 神田 光郎, 園原 史訓, 高見 秀樹, 猪川 祥邦, 服部 憲史, 林 真路, 田中 千恵, 山田 豪, 中山 吾郎, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 121回   page: SF - 1   2021.4

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  50. 膵癌における術前治療中の腫瘍マーカーの比較・検討 Reviewed

    砂川 祐輝, 山田 豪, 田中 伸孟, 園原 史訓, 猪川 祥邦, 高見 秀樹, 林 真路, 服部 憲史, 神田 光郎, 田中 千恵, 中山 吾郎, 小池 聖彦, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 121回   page: PS - 4   2021.4

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  51. 膵癌におけるオリゴメタスタシスの臨床的意義 Reviewed

    山中 雅也, 山田 豪, 林 真路, 園原 史訓, 猪川 祥邦, 高見 秀樹, 服部 憲史, 神田 光郎, 田中 千恵, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 121回   page: SF - 5   2021.4

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  52. 胃癌切除後予後と原発巣組織中CRABP1発現の相関性の検討 Reviewed

    坂田 和規, 神田 光郎, 清水 大, 園原 史訓, 高見 秀樹, 猪川 祥邦, 服部 憲史, 林 真路, 田中 千恵, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 121回   page: PS - 5   2021.4

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  53. 胃癌に対する腹腔鏡下手術でのIndocyanine Green蛍光法を用いたマーキング法の成績 Reviewed

    佐藤 敏, 田中 千恵, 園原 史訓, 清水 大, 高見 秀樹, 猪川 祥邦, 服部 憲史, 林 真路, 神田 光郎, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 121回   page: PS - 6   2021.4

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  54. Genome-wide identification and characterization of circular RNA in resected hepatocellular carcinoma and background liver tissue. Reviewed International journal

    Yuki Sunagawa, Suguru Yamada, Fuminori Sonohara, Keisuke Kurimoto, Nobutake Tanaka, Yunosuke Suzuki, Yoshikuni Inokawa, Hideki Takami, Masamichi Hayashi, Mitsuro Kanda, Chie Tanaka, Goro Nakayama, Masahiko Koike, Yasuhiro Kodera

    Scientific reports   Vol. 11 ( 1 ) page: 6016 - 6016   2021.3

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    Circular RNA (circRNA) is a type of non-coding RNA known to affect cancer-related micro RNAs and various transcription factors. circRNA has promise as a cancer-related biomarker because its circular structure affords high stability. We found using high-throughput sequencing that seven candidate circRNAs (hsa_circ_0041150, hsa_circ_0025624, hsa_circ_0001020, hsa_circ_0028129, hsa_circ_0008558, hsa_circ_0036683, hsa_circ_0058087) were downregulated in HCC. The expression of these circRNAs was examined by quantitative PCR in 233 sets of HCC and matched background normal liver tissues, and correlations between candidate circRNA expression and prognosis were evaluated. The results of quantitative PCR showed that expression of hsa_circ_0041150, hsa_circ_0001020 and hsa_circ_0008558 was significantly lower in HCC than in background normal liver tissues. Kaplan-Meier analysis revealed that low expression of hsa_circ_0001020, hsa_circ_0036683, and hsa_circ_0058087 was associated with poor recurrence-free (RFS) and overall survival (OS) in HCC. Additionally, multivariate analysis revealed that low hsa_circ_0036683 expression was a significant prognostic factor, independent from other clinicopathological features, for inferior RFS and OS. There was no significant association between the expression of these circRNAs and hepatitis B/C status or cirrhosis. This study therefore identified circRNAs as potential prognostic markers for patients who undergo curative surgery for HCC and highlighted hsa_circ_0036683 as the most useful biomarker.

    DOI: 10.1038/s41598-021-85237-y

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  55. ETNK2のアポトーシス調整を介した胃癌肝転移形成との関連性(ETNK2 promotes hepatic metastasis of gastric cancer via the p53-Bcl-2 related apoptosis) Reviewed

    三輪 高嗣, 神田 光郎, 田中 千恵, 清水 大, 園原 史訓, 高見 秀樹, 猪川 祥邦, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本胃癌学会総会記事   Vol. 93回   page: 244 - 244   2021.3

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  56. StageIII胃癌に対する術前化学療法後胃切除術の短期成績の検討(Short-term outcomes of gastrectomy after neoadjuvant chemotherapy for stage III gastric cance) Reviewed

    梅田 晋一, 神田 光郎, 中西 香企, 清水 大, 田中 千恵, 藤原 道隆, 小寺 泰弘

    日本胃癌学会総会記事   Vol. 93回   page: 288 - 288   2021.3

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  57. 顕微鏡的断端陽性が予後に与える影響(Microscopic Positive Margin After Gastrectomy Increases Recurrences of Gastric Cancer) Reviewed

    中西 香企, 神田 光郎, 伊藤 誠二, 望月 能成, 寺本 仁, 石榑 清, 村井 俊文, 浅田 崇洋, 清水 大, 田中 千恵, 藤原 道隆, 小寺 泰弘

    日本胃癌学会総会記事   Vol. 93回   page: 259 - 259   2021.3

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  58. Development of novel combination cancer immunotherapy using anti-PD-1 and anti-PD-L1 antibody Reviewed

    Hasegawa Hirotaka, Sugiyama Daisuke, Kanda Mitsuro, Hayashi Masamichi, Tanaka Chie, Yamada Suguru, Nakayama Goro, Koike Masahiko, Nomoto Shuji, Fujiwara Michitaka, Kodera Yasuhiro, Nishikawa Hiroyoshi

    CANCER SCIENCE   Vol. 112   page: 741 - 741   2021.2

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  59. STRA6 expression serves as a prognostic biomarker of gastric cancer Reviewed

    Nakamura Shunsuke, Kanda Mitsuro, Shimizu Dai, Sawaki Koichi, Tanaka Chie, Hattori Norifumi, Hayashi Masamichi, Yamada Suguru, Koike Masahiko, Kodera Yasuhiro

    CANCER SCIENCE   Vol. 112   page: 780 - 780   2021.2

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  60. Function and prognostic value of melanoma-associated antigen-D4 protein in esophageal squamous cell carcinoma Reviewed

    Sawaki Koichi, Kanda Mitsuro, Sato Yusuke, Shimizu Dai, Uno Yasuo, Umeda Shinichi, Hattori Norifumi, Hayashi Masamichi, Tanaka Chie, Yamada Suguru, Nakayama Goro, Motoyama Satoru, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    CANCER SCIENCE   Vol. 112   page: 531 - 531   2021.2

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  61. Circulating miRNA signature of esophageal squamous cell carcinoma diagnosis:retro-prospective multinational cohort study Reviewed

    Miyoshi Jinsei, Toden Shusuke, Izumi Daisuke, Kanda Mitsuro, Sato Yasushi, Muguruma Naoki, Baba Hideo, Kodera Yasuhiro, Goel Ajay, Takayama Tetsuji

    CANCER SCIENCE   Vol. 112   page: 527 - 527   2021.2

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  62. Randomised phase II trial of capecitabine plus oxaliplatin with continuous versus intermittent use of oxaliplatin as adjuvant chemotherapy for stage II/III colon cancer (CCOG-1302 study) Reviewed

    Nakayama Goro, Takano Nao, Taniguchi Hiroya, Ishigure Kiyoshi, Yokoyama Hiroyuki, Teramoto Hitoshi, Hashimoto Ryoji, Sakai Mitsuru, Ishiyama Akiharu, Kinoshita Takashi, Hayashi Naomi, Nakamura Masanori, Hattori Norifumi, Sato Yusuke, Umeda Shinichi, Uehara Kei, Aiba Toshisada, Sonohara Fuminori, Hayashi Masamichi, Kanda Mitsuro, Kobayashi Daisuke, Tanaka Chie, Yamada Suguru, Koike Masahiko, Fujiwara Michitaka, Murotani Kenta, Ando Masahiko, Ando Yuichi, Muro Kei, Kodera Yasuhiro

    EUROPEAN JOURNAL OF CANCER   Vol. 144   page: 61 - 71   2021.2

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    DOI: 10.1016/j.ejca.2020.11.007

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  63. Tissue RNFT2 Expression Levels Are Associated With Peritoneal Recurrence and Poor Prognosis in Gastric Cancer. Reviewed International journal

    Masahiro Sasahara, Mitsuro Kanda, Dai Shimizu, Chie Tanaka, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Goro Nakayama, Yasuhiro Kodera

    Anticancer research   Vol. 41 ( 2 ) page: 609 - 617   2021.2

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    BACKGROUND/AIM: Disease recurrence is frequently observed after curative resection of advanced gastric cancer resulting in a poor prognosis. In the present study, we identified a candidate biomarker to predict recurrence and prognosis after curative resection of gastric cancer. MATERIALS AND METHODS: A transcriptome analysis was conducted using surgically resected cancerous tissue from patients with metastatic gastric cancer to identify genes that are upregulated in primary and metastatic tissues. RESULTS: Ring finger protein, transmembrane 2 (RNFT2) mRNA expression was upregulated in primary gastric cancer tissues and metastases compared with non-cancerous tissues. RNFT2 expression in gastric cancer cell lines was positively correlated with the EMT-related molecules GSC, MMP9, and RAC1. The RNFT2 high expression group exhibited a significantly shorter postoperative overall survival. Peritoneal recurrence was significantly higher in the RNFT2 high expression group. CONCLUSION: RNFT2 mRNA expression predicts peritoneal recurrence and is a potential prognostic biomarker for gastric cancer following curative gastrectomy.

    DOI: 10.21873/anticanres.14812

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  64. Age-Related Differences in the Prognosis of Pancreatic Cancer According to Perioperative Systemic Therapy. Reviewed International journal

    Fuminori Sonohara, Suguru Yamada, Keisuke Kurimoto, Yoshikuni Inokawa, Hideki Takami, Masamichi Hayashi, Dai Shimizu, Norifumi Hattori, Mitsuro Kanda, Chie Tanaka, Goro Nakayama, Masahiko Koike, Tsutomu Fujii, Yasuhiro Kodera

    Pancreas   Vol. 50 ( 1 ) page: 37 - 46   2021.1

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    OBJECTIVES: In this study, we retrospectively assessed the feasibility and prognostic efficacy of perioperative chemo(radio)therapy for pancreatic cancer (PC) patients according to age. METHODS: A total of 556 consecutive patients who underwent curative-intent pancreatectomy for PC between 2000 and 2018 were enrolled. RESULTS: Of the 556 patients who underwent resection, 95 (17%) were elderly (age, ≥75 years). Postoperative complications did not significantly differ between the 2 age groups, and postoperative prognoses were also similar (recurrence-free survival [RFS], P = 0.68; overall survival [OS], P = 0.28). In this cohort, 103 patients (19%) underwent preoperative chemo(radio)therapy, and 417 (77%) underwent postoperative chemotherapy. Perioperative therapy was found to be significantly beneficial for younger patients (preoperative therapy: RFS, P = 0.006; OS, P < 0.001; postoperative therapy: RFS, P < 0.001; OS, P < 0.001). Conversely, no significant survival benefit of perioperative therapy was found for the elderly (preoperative therapy: RFS, P = 0.28; OS, P = 0.44; postoperative therapy: RFS, P = 0.77; OS, P = 0.08). CONCLUSIONS: This study demonstrated that, although perioperative therapy is feasible for selected elderly patients with PC, this approach might not be as beneficial as it is for younger PC patients.

    DOI: 10.1097/MPA.0000000000001712

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  65. Newly developed primary malignancies in long-term survivors who underwent curative esophagectomy for squamous cell carcinoma of the esophagus. Reviewed

    Dai Shimizu, Masahiko Koike, Mitsuro Kanda, Fuminori Sonohara, Norifumi Hattori, Masamichi Hayashi, Chie Tanaka, Suguru Yamada, Yasuhiro Kodera

    Surgery today   Vol. 51 ( 1 ) page: 153 - 158   2021.1

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    PURPOSE: We evaluated the efficacy of the long-term follow-up of patients who underwent radical esophagectomy for esophageal squamous cell carcinoma (ESCC) to screen for recurrence and new primary malignancies. METHODS: We retrospectively collected 448 ESCC patients who underwent radical esophagectomy. Esophagogastroduodenoscopy, computed tomography, a stool test and the assessment of the serum concentration of squamous cell carcinoma antigen and carcinoembryonic antigen were performed annually, even over 5 years after esophagectomy. The incidence of ESCC recurrence and new primary malignancies was investigated. RESULTS: We enrolled 222 patients who survived at least 5 years after esophagectomy. A total of 104 new primary malignancies occurred in 82 patients (36.9%) after esophagectomy. Twenty-one malignancies were in the head and neck region, 14 in the residual esophagus, 13 in the prostate and 11 in the gastric tube and lung. Patients who developed new primary malignancies after esophagectomy had a significantly higher Brinkman index than those without new malignancies. An endoscopic approach successfully treated 92.9% of carcinomas in the residual esophagus, 90.9% of cancers in the gastric tube and 42.9% of carcinomas in the head and neck region. CONCLUSION: The incidence of new primary malignancies was higher than the age-standardized incidence. Long-term follow-up and systemic screening may increase the probability of an early diagnosis and subsequent low-invasive treatment.

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  66. Pancreatic Fat and Body Composition Measurements by Computed Tomography are Associated with Pancreatic Fistula After Pancreatectomy. Reviewed International journal

    Katsuhito Tanaka, Suguru Yamada, Fuminori Sonohara, Hideki Takami, Masamichi Hayashi, Mitsuro Kanda, Daisuke Kobayashi, Chie Tanaka, Goro Nakayama, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera

    Annals of surgical oncology   Vol. 28 ( 1 ) page: 530 - 538   2021.1

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    OBJECTIVES: Postoperative pancreatic fistula (POPF) is the most threatening complication after pancreatectomy. This study aimed to directly assess pancreatic fatty infiltration with preoperative computed tomography (CT) imaging and to investigate whether a preoperative analysis of patient variables, including CT characteristics and clinical factors, can predict POPF. METHODS: We enrolled 150 consecutive patients who underwent curative pancreatectomy. Radiographic factors, including pancreatic fat volume, were measured using preoperative CT imaging and the predictive factors were explored using univariate and multivariate analyses. RESULTS: POPF developed in 30 patients (20.0%). The ratio of pancreatic fat (RPF) ≥ 4.83% was associated with a risk of POPF, high body mass index (BMI), and obese body habitus. Patients with POPF were significantly more likely to have high BMI (≥ 25 kg/m2), obese body habitus, and an RPF ≥ 4.83% than patients without POPF. In the multivariate analysis, visceral fat area/skeletal muscle index (VFA/SMI) ≥ 1.94 (odds ratio [OR] 4.28, 95% confidence interval [CI] 1.43-12.9, p = 0.0095) was the sole independent predictive factor for POPF. For patients with a soft pancreas, VFA/SMI ≥ 1.94 (OR 5.67, 95% CI 2.05-15.7, p = 0.0008) was again the sole independent predictive factor for POPF. CONCLUSION: Preoperative CT images can examine pancreatic fatty infiltration, and patients who had POPF were significantly associated with a high RPF. Among several parameters, VFA/SMI was the only independent predictive factor for clinically relevant POPF. Preoperative evaluation of these body composition variables and the pancreatic configuration could be useful for predicting POPF.

    DOI: 10.1245/s10434-020-08581-9

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  67. Optimal Preoperative Multidisciplinary Treatment in Borderline Resectable Pancreatic Cancer. Reviewed International journal

    Nana Kimura, Suguru Yamada, Hideki Takami, Kenta Murotani, Isaku Yoshioka, Kazuto Shibuya, Fuminori Sonohara, Yui Hoshino, Katsuhisa Hirano, Toru Watanabe, Hayato Baba, Kosuke Mori, Takeshi Miwa, Mitsuro Kanda, Masamichi Hayashi, Koshi Matsui, Tomoyuki Okumura, Yasuhiro Kodera, Tsutomu Fujii

    Cancers   Vol. 13 ( 1 )   2021.1

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    Background: The objective of this study was to investigate the optimal neoadjuvant therapy (NAT) for borderline resectable pancreatic cancer invading the portal vein (BR-PV) or abutting major arteries (BR-A). Methods: We retrospectively analyzed 88 patients with BR-PV and 111 patients with BR-A. Results: In BR-PV patients who underwent upfront surgery (n = 46)/NAT (n = 42), survival was significantly better in the NAT group (3-year overall survival (OS): 5.8%/35.5%, p = 0.004). In BR-A patients who underwent upfront surgery (n = 48)/NAT (n = 63), survival was also significantly better in the NAT group (3-year OS:15.5%/41.7%, p < 0.001). The prognosis tended to be better in patients who received newer chemotherapeutic regimens, such as FOLFIRINOX and gemcitabine with nab-paclitaxel. In 36 BR-PV patients who underwent surgery after NAT, univariate analysis revealed that normalization of tumor marker (TM) levels (p = 0.028) and preoperative high prognostic nutritional index (PNI) (p = 0.022) were significantly associated with a favorable prognosis. In 39 BR-A patients who underwent surgery after NAT, multivariate analysis revealed that preoperative PNI > 42.5 was an independent prognostic factor (HR: 0.15, p = 0.014). Conclusions: NAT using newer chemotherapy is essential for improving the prognosis of BR pancreatic cancer. These findings suggest that prognosis may be prolonged by maintaining good nutritional status during preoperative treatment.

    DOI: 10.3390/cancers13010036

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  68. Different Characteristics of Serum Alfa Fetoprotein and Serum Des-gamma-carboxy Prothrombin in Resected Hepatocellular Carcinoma Reviewed

    Hayashi Masamichi, Yamada Suguru, Takano Nao, Okamura Yukiyasu, Takami Hideki, Inokawa Yoshikuni, Sonohara Fuminori, Tanaka Nobutake, Shimizu Dai, Hattori Norifumi, Kanda Mitsuro, Tanaka Chie, Nakayama Goro, Koike Masahiko, Kodera Yasuhiro

    IN VIVO   Vol. 35 ( 3 ) page: 1749 - 1760   2021

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    DOI: 10.21873/invivo.12434

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  69. Amido-Bridged Nucleic Acid-Modified Antisense Oligonucleotides Targeting SYT13 to Treat Peritoneal Metastasis of Gastric Cancer Reviewed

    Mitsuro Kanda, Yuuya Kasahara, Dai Shimizu, Takashi Miwa, Shinichi Umeda, Koichi Sawaki, Shunsuke Nakamura, Yasuhiro Kodera, Satoshi Obika

    Molecular Therapy - Nucleic Acids   Vol. 22   page: 791 - 802   2020.12

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    DOI: 10.1016/j.omtn.2020.10.001

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  70. Novel Prognostic Implications of Methylated RNA and Demethylases in Resected HCC and Background Liver Tissue. Reviewed International journal

    Nobuhiko Nakagawa, Katsuhito Tanaka, Fuminori Sonohara, Raju Kandimalla, Yuki Sunagawa, Yoshikuni Inokawa, Hideki Takami, Masamichi Hayashi, Suguru Yamada, Mitsuro Kanda, Chie Tanaka, Goro Nakayama, Masahiko Koike, Yasuhiro Kodera

    Anticancer research   Vol. 40 ( 12 ) page: 6665 - 6676   2020.12

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    BACKGROUND/AIM: N6-Methyladenosine (m6A), the most abundant internal modification of RNA, plays a critical role in cancer development. However, the clinical implications of m6A in hepatocellular carcinoma (HCC) remain unclear. MATERIALS AND METHODS: We analyzed 177 HCC and paired noncancerous liver tissues from patients who underwent hepatectomy according to global m6A quantification and expression of m6A demethylases fat mass and obesity-associated protein (FTO) and alpha-ketoglutarate-dependent dioxygenase alkB homolog 5 (ALKBH5). RESULTS: The global m6A quantification revealed no significant difference between HCC and non-cancerous tissue. The expression of m6A demethylases FTO and ALKBH5, was significantly lower in HCC than in non-cancerous tissues (both p<0.001). Furthermore, low ALKBH5 expression in non-cancerous tissues was significantly correlated with worse recurrence-free survival (median of 16.3 vs. 38.9 months, p=0.001). CONCLUSION: m6A in HCC and its demethylase in surrounding non-cancerous liver tissues might be involved in inherent mechanisms for HCC development and affect malignant potential after HCC resection.

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  71. Accurate Risk Stratification of Patients with Node-Positive Gastric Cancer by Lymph Node Ratio. Reviewed International journal

    Shunsuke Nakamura, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

    World journal of surgery   Vol. 44 ( 12 ) page: 4184 - 4192   2020.12

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    BACKGROUND: We aimed to clarify the utility of lymph node ratio (LNR) for assessing the prognosis of patients with node-positive gastric cancer after curative gastrectomy. METHODS: We retrospectively analyzed data of 973 patients with node-positive gastric cancer who had undergone curative gastrectomy at nine institutions from 2010 to 2014. Survival analysis was performed by comparing LNR low and high groups according to the optimal cutoff value of LNR, which was determined using receiver operating characteristic curve analysis. RESULTS: LNR high was significantly associated with shorter disease-free survival and was an independent predictor of recurrence in all patients. Moreover, we obtained the similar results from analysis of each N stage. The prevalence of lymph node and peritoneal recurrence appeared to be higher in the LNR high group. Correlation analysis showed that LNR was negatively correlated with the number of retrieved nodes within every N stage; however, disease-free survival did not differ significantly between LNR low and high groups of each N stage with 16-30, 31-40, or >40 retrieved nodes. CONCLUSIONS: LNR is a strong prognostic factor and predictor of recurrence in patients with node-positive gastric cancer who have undergone curative gastrectomy. The combination of LNR and N staging permits more accurate prognostic stratification of patients with gastric cancer and may contribute to developing novel prognostic models.

    DOI: 10.1007/s00268-020-05739-0

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  72. AMIGO2 Expression as a Potential Prognostic Biomarker for Gastric Cancer. Reviewed International journal

    Shunsuke Nakamura, Mitsuro Kanda, Dai Shimizu, Chie Tanaka, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Suguru Yamada, Goro Nakayama, Kenji Omae, Masahiko Koike, Yasuhiro Kodera

    Anticancer research   Vol. 40 ( 12 ) page: 6713 - 6721   2020.12

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    BACKGROUND/AIM: Although our understanding of the molecular mechanisms of gastric cancer (GC) development and progression is steadily deepening, the clinical outcome of GC patients remains inadequate. The identification of molecules associated with GC will help improve prognosis. We aimed to identify the molecules involved in GC progression and metastasis. MATERIALS AND METHODS: Transcriptome analysis was performed on surgically resected gastric tissue from patients with hepatic metastasis. Fourteen cell lines and 230 pairs of primary GC tissues and their corresponding normal adjacent tissues were included in the mRNA expression analysis. RESULTS: Adhesion molecule with Ig like domain 2 (AMIGO2) was identified as a gene of interest. The levels of AMIGO2 mRNA positively correlated with those encoding FOXC2, NODAL, GEMIN2 and negatively correlated with TFPI2. Patients with high AMIGO2 expression experienced significantly shorter disease-free survival and overall survival. High levels of AMIGO2 were associated with poor prognosis. CONCLUSION: Patients with GC with high AMIGO2 mRNA levels experienced significantly shorter survival, suggesting that AMIGO2 may serve as a prognostic biomarker for GC.

    DOI: 10.21873/anticanres.14694

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  73. DAA時代のHCV治療がもたらす切除可能HCCへの臨床的影響の検討 Reviewed

    園原 史訓, 山田 豪, 高見 秀樹, 猪川 祥邦, 林 真路, 神田 光郎, 田中 千恵, 中山 吾郎, 小池 聖彦, 小寺 泰弘

    日本消化器外科学会総会   Vol. 75回   page: O12 - 3   2020.12

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  74. 尿中cell free DNAを用いた膵癌診断法の開発 Reviewed

    林 真路, 山田 豪, 高見 秀樹, 猪川 祥邦, 園原 史訓, 神田 光郎, 田中 千恵, 中山 吾郎, 小池 聖彦, 小寺 泰弘

    日本消化器外科学会総会   Vol. 75回   page: P276 - 5   2020.12

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  75. 胃癌における周術期化学療法の新知見 胃癌に対するS-1補助療法の臨床問題に答えるための多施設データセット解析(New findings on perioperative chemotherapy for gastric cancer Multi-institutional dataset analysis to answer clinical questions of adjuvant S-1 for gastric cancer) Reviewed

    Nakanishi Koki, Kanda Mitsuro, Ito Seiji, Mochizuki Yoshinari, Teramoto Hitoshi, Ishigure Kiyoshi, Shimizu Dai, Tanaka Chie, Fujiwara Michitaka, Kodera Yasuhiro

    日本消化器外科学会総会   Vol. 75回   page: WS4 - 6   2020.12

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  76. MZB1 expression indicates poor prognosis in estrogen receptor-positive breast cancer Reviewed

    Watanabe Manabu, Shibata Masahiro, Inaishi Takahiro, Ichikawa Takahiro, Soeda Ikumi, Miyajima Noriyuki, Takano Yuko, Takeuchi Dai, Tsunoda Nobuyuki, Kanda Mitsuro, Kikumori Toyone, Kodera Yasuhiro, Nagino Masato

    ONCOLOGY LETTERS   Vol. 20 ( 5 ) page: 198   2020.11

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    DOI: 10.3892/ol.2020.12059

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  77. An Open-Label Single-Arm Phase II Study of Treatment with Neoadjuvant S-1 Plus Cisplatin for Clinical Stage III Squamous Cell Carcinoma of the Esophagus. Reviewed International journal

    Mitsuro Kanda, Masahiko Koike, Naoki Iwata, Dai Shimizu, Chie Tanaka, Norifumi Hattori, Masamichi Hayashi, Suguru Yamada, Kenji Omae, Goro Nakayama, Yasuhiro Kodera

    The oncologist   Vol. 25 ( 11 ) page: E1650 - E1654   2020.11

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    LESSONS LEARNED: Two courses of neoadjuvant therapy using S-1 plus cisplatin for clinical stage III esophageal squamous cell carcinoma did not achieve expected response rate according to endoscopic evaluation of primary tumors. Subsequent esophagectomy was safely performed. BACKGROUND: In Japan, esophagectomy after two courses of 5-fluorouracil plus cisplatin is regarded a standard strategy for treating stage II or III esophageal squamous cell carcinoma (ESCC). However, 5-fluorouracil plus cisplatin does not benefit cohorts with clinical stage III ESCC, suggesting the need for a more effective regimen. METHODS: A single-arm, open-label phase II trial was conducted to evaluate the safety and efficacy of two courses of neoadjuvant chemotherapy using S-1 plus cisplatin (NAC-SP) for clinical stage III ESCC. The primary endpoint was overall response rate as defined by endoscopic evaluation of primary tumors. RESULTS: We enrolled 26 patients. The completion rate for the two courses of NAC-SP was 61.5%. Grade 3 or higher adverse events were experienced by 38.4% of patients. The treatment response rate according to endoscopic findings, acquired before the second course, was 34.6% and below the expected level (55.0%). The morbidity rate of patients who underwent radical subtotal esophagectomy (96.2%) was 32.0%. Repeat surgery was unnecessary, and surgery-associated deaths did not occur. The 5-year progression-free survival (PFS) and overall survival (OS) rates were 84.6% and 92.2%, respectively. CONCLUSION: We demonstrate safety of NAC-SP, but not its efficacy, for patients with clinical stage III ESCC. Subsequent esophagectomy was safely performed.

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  78. D2 lymph node dissection confers little benefit on the overall survival of older patients with resectable gastric cancer: a propensity score-matching analysis of a multi-institutional dataset. Reviewed

    Takahiro Shinozuka, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

    Surgery today   Vol. 50 ( 11 ) page: 1434 - 1442   2020.11

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    PURPOSE: Aging societies comprise an increasing number of elderly gastric cancer (GC) patients. We herein attempted to determine whether D2 lymphadenectomy is beneficial for older GC patients. METHODS: We retrospectively analyzed a multi-institutional dataset including 3484 patients who received surgical resection for GC. For the analysis, we selected patients aged ≥ 80 years who were clinically diagnosed with T1N + or T2-4 GC. To balance the essential variables including the type of gastrectomy and the stage of progression, propensity score matching was conducted, and we compared the background clinical factors and postoperative outcomes of the patients allocated to the D2 (n = 87) and non-D2 (n = 87) dissection groups. RESULTS: The D2 group had significantly longer operative times, more blood loss, and more retrieved lymph nodes (median 32 vs 24, P < 0.001) than the non-D2 group. The D2 group had a greater incidence of intra-abdominal abscesses (grade ≥ II in the Clavien-Dindo classification) than the non-D2 group (3.5% vs 0%, P = 0.040). The overall disease-specific and relapse-free survival rates of the D2 group tended to be poorer than those of the non-D2 group (hazard ratios 1.49, 1.70 and 1.14, respectively). CONCLUSIONS: D2 lymphadenectomy for older patients with GC conferred little benefit regarding overall survival despite an occurrence of increased complication rates.

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  79. Complex roles of the actin-binding protein Girdin/GIV in DNA damage-induced apoptosis of cancer cells. Reviewed International journal

    Chen Chen, Atsushi Enomoto, Liang Weng, Tetsuro Taki, Yukihiro Shiraki, Shinji Mii, Ryosuke Ichihara, Mitsuro Kanda, Masahiko Koike, Yasuhiro Kodera, Masahide Takahashi

    Cancer science   Vol. 111 ( 11 ) page: 4303 - 4317   2020.11

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    The actin-binding protein Girdin is a hub protein that interacts with multiple proteins to regulate motility and Akt and trimeric G protein signaling in cancer cells. Girdin expression correlates with poor outcomes in multiple human cancers. However, those findings are not universal, as they depend on study conditions. Those data suggest that multiple aspects of Girdin function and its role in tumor cell responses to anticancer therapeutics must be reconsidered. In the present study, we found that Girdin is involved in DNA damage-induced cancer cell apoptosis. An esophageal cancer cell line that exhibited high Girdin expression showed a marked sensitivity to UV-mediated DNA damage compared to a line with low Girdin expression. When transcriptional activation of endogenous Girdin was mediated by an engineered CRISPR/Cas9 activation system, sensitivity to DNA damage increased in both stationary and migrating HeLa cancer cells. High Girdin expression was associated with dysregulated cell cycle progression and prolonged G1 and M phases. These features were accompanied by p53 activation, which conceivably increases cancer cell vulnerability to UV exposure. These data highlight the importance of understanding complex Girdin functions that influence cancer cell sensitivity to therapeutics.

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  80. The efficacy of oxaliplatin combination adjuvant chemotherapy for elderly patients with stage III colorectal cancer. Reviewed

    Naomi Hayashi, Mitsuro Kanda, Kenji Omae, Yasuhiro Kodera

    Nagoya journal of medical science   Vol. 82 ( 4 ) page: 603 - 611   2020.11

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    Now we are facing to aging society. We aimed to determine the long-term outcomes receiving adjuvant chemotherapy among elderly patients with stage III colorectal cancer. Elderly patients (≧65 years, n=91) diagnosed as stage III colorectal cancer and received adjuvant chemotherapy were retrieved from the database and classified into two groups according to whether the patient received monotherapy (n=65) or doublet therapy(n=26). Recurrence-free survival and overall survival were compared between the groups. To balance the essential variables, we conducted propensity score matching. After one-to-one propensity score matching, each group consisted of 22 patients. No significant difference was detected by comprehensive geriatric assessment 7. Overall survival was significantly longer in the monotherapy group. Adverse events occurred more frequently in the doublet therapy group. Monotherapy may improve the long-term outcome of elderly patients while the adverse events were less frequent.

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  81. 劇症型A群β溶連菌感染症による原発性腹膜炎の1例 Reviewed

    砂川 祐輝, 猪川 祥邦, 山田 豪, 園原 史訓, 高見 秀樹, 林 真路, 服部 憲史, 神田 光郎, 田中 千恵, 小林 大介, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本臨床外科学会雑誌   Vol. 81 ( 11 ) page: 2399 - 2399   2020.11

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  82. 胃 診断 Reviewed

    中村 俊介, 神田 光郎, 清水 大, 澤木 康一, 田中 千恵, 服部 憲史, 園原 史訓, 高見 秀樹, 猪川 祥邦, 林 真路, 山田 豪, 小池 聖彦, 小寺 泰弘

    日本消化器外科学会雑誌   Vol. 53 ( Suppl.2 ) page: 296 - 296   2020.11

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  83. 膵臓 悪性 Reviewed

    山田 豪, 高見 秀樹, 園原 史訓, 猪川 祥邦, 林 真路, 服部 憲史, 神田 光郎, 田中 千恵, 中山 吾郎, 小池 聖彦, 藤井 努, 小寺 泰弘

    日本消化器外科学会雑誌   Vol. 53 ( Suppl.2 ) page: 316 - 316   2020.11

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  84. 膵臓 化学療法 Reviewed

    砂川 祐輝, 山田 豪, 山中 雅也, 鈴木 雄之典, 中川 暢彦, 加藤 吉康, 田中 伸孟, 栗本 景介, 園原 史訓, 猪川 祥邦, 高見 秀樹, 林 真路, 神田 光郎, 田中 千恵, 中山 吾郎, 小池 聖彦, 小寺 泰弘

    日本消化器外科学会雑誌   Vol. 53 ( Suppl.2 ) page: 311 - 311   2020.11

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  85. Characteristics Associated with Nodal and Distant Recurrence after Curative Resection of Squamous Cell Carcinoma of the Thoracic Esophagus Reviewed

    Kanda Mitsuro, Koike Masahiko, Shimizu Dai, Tanaka Chie, Hayashi Masamichi, Hattori Norifumi, Yamada Suguru, Nakayama Goro, Fujiwara Michitaka, Kodera Yasuhiro

    JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS   Vol. 231 ( 4 ) page: E121 - E121   2020.10

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  86. 予定残肝ICG消失率(ICG-Krem)の術後肝不全発症予測因子としての有用性 Reviewed

    砂川 祐輝, 山田 豪, 園原 史訓, 猪川 祥邦, 高見 秀樹, 林 真路, 服部 憲史, 神田 光郎, 田中 千恵, 中山 吾郎, 小池 聖彦, 小寺 泰弘

    日本癌治療学会学術集会抄録集   Vol. 58回   page: O60 - 4   2020.10

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  87. 予定残肝ICG消失率(ICG-Krem)の術後肝不全発症予測因子としての有用性 Reviewed

    砂川 祐輝, 山田 豪, 園原 史訓, 猪川 祥邦, 高見 秀樹, 林 真路, 服部 憲史, 神田 光郎, 田中 千恵, 中山 吾郎, 小池 聖彦, 小寺 泰弘

    日本癌治療学会学術集会抄録集   Vol. 58回   page: O60 - 4   2020.10

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  88. 胃癌組織中STRA6発現の臨床的意義 Reviewed

    中村 俊介, 神田 光郎, 清水 大, 澤木 康一, 田中 千恵, 服部 憲史, 林 真路, 山田 豪, 小池 聖彦, 小寺 泰弘

    日本癌学会総会記事   Vol. 79回   page: PJ14 - 7   2020.10

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  89. 食道扁平上皮癌におけるMAGE-D4発現の臨床的意義の検討 Reviewed

    澤木 康一, 神田 光郎, 佐藤 雄亮, 清水 大, 宇野 泰朗, 梅田 晋一, 服部 憲史, 林 真路, 田中 千恵, 山田 豪, 中山 吾郎, 本山 悟, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本癌学会総会記事   Vol. 79回   page: OJ15 - 9   2020.10

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  90. 血清miRNAシグネチャーを用いた食道扁平上皮癌の早期診断モデルの構築 後ろ向き・前向き・多国籍試験 Reviewed

    三好 人正, 東田 周祐, 泉 大輔, 神田 光郎, 佐藤 康史, 六車 直樹, 馬場 秀夫, 小寺 泰弘, ゴエル・アジャイ, 高山 哲治

    日本癌学会総会記事   Vol. 79回   page: OE15 - 6   2020.10

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  91. 膵癌における術前治療中のSpan-1の臨床的意義 Reviewed

    砂川 祐輝, 山田 豪, 園原 史訓, 猪川 祥邦, 高見 秀樹, 林 真路, 清水 大, 服部 憲史, 神田 光郎, 田中 千恵, 中山 吾郎, 小池 聖彦, 小寺 泰弘

    日本臨床外科学会雑誌   Vol. 81 ( 増刊 ) page: 463 - 463   2020.10

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  92. ASO Author Reflections: Characteristics Associated with Nodal and Distant Recurrence After Radical Esophagectomy for Squamous Cell Carcinoma of the Thoracic Esophagus Reviewed

    Kanda Mitsuro, Koike Masahiko, Kodera Yasuhiro

    ANNALS OF SURGICAL ONCOLOGY   Vol. 27 ( 9 ) page: 3206 - 3207   2020.9

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    DOI: 10.1245/s10434-020-08413-w

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  93. ASO Author Reflections: Expression and Malignant Potential of B4GALNT4 in Esophageal Squamous Cell Carcinoma Reviewed

    Baba Hayato, Kanda Mitsuro, Kodera Yasuhiro, Fujii Tsutomu

    ANNALS OF SURGICAL ONCOLOGY   Vol. 27 ( 9 ) page: 3257 - 3258   2020.9

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    DOI: 10.1245/s10434-020-08458-x

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  94. Characteristics Associated with Nodal and Distant Recurrence After Radical Esophagectomy for Squamous Cell Carcinoma of the Thoracic Esophagus. Reviewed International journal

    Mitsuro Kanda, Masahiko Koike, Dai Shimizu, Chie Tanaka, Norifumi Hattori, Masamichi Hayashi, Suguru Yamada, Kenji Omae, Yasuhiro Kodera

    Annals of surgical oncology   Vol. 27 ( 9 ) page: 3195 - 3205   2020.9

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    BACKGROUND: Recurrence after radical resection of esophageal squamous cell carcinoma (ESCC) is common. Limited evidence is available about the differences in clinical characteristics, risk factors, and prognostic significance between nodal and distant recurrence of thoracic ESCC. PATIENTS AND METHODS: We retrospectively analyzed 341 patients who underwent radical resection of thoracic ESCC and experienced (1) initial recurrence only in lymph nodes (n = 39), (2) recurrence only at distant organs (n = 57), or (3) no recurrences (n = 245) after follow-up ≥ 24 months. Clinicopathological characteristics, survival times, and risk factors were compared between the nodal and distant recurrence groups. RESULTS: The median follow-up time was 57.8 months. Metastasectomy as initial treatment for the recurrence was performed for six (15.4%) patients in the nodal recurrence group and one patient in the distant recurrence group. Compared with the nodal recurrence group, patients with distant recurrence had significantly shorter disease-free survival [hazard ratio (HR) 1.68, 95% confidence interval (CI) 1.10-2.57, P = 0.0169], postrecurrence survival (HR 1.77, 95% CI 1.01-3.10, P = 0.0476), and overall survival (HR 1.98, 95% CI 1.12-3.51, P = 0.0193). The distant recurrence group had significantly larger macroscopic tumor size and more advanced pathological T stage than the nodal recurrence group, whereas preoperative treatment, tumor location, number of fields dissected, tumor differentiation, lymphatic involvement, and vessel invasion were not significantly different between the two groups. CONCLUSIONS: Survival times and recurrence risk factors differed between patients with nodal and distant recurrence after radical resection of thoracic ESCC.

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  95. Expression and Malignant Potential of B4GALNT4 in Esophageal Squamous Cell Carcinoma Reviewed

    Baba Hayato, Kanda Mitsuro, Sato Yusuke, Sawaki Koichi, Shimizu Dai, Koike Masahiko, Motoyama Satoru, Kodera Yasuhiro, Fujii Tsutomu

    ANNALS OF SURGICAL ONCOLOGY   Vol. 27 ( 9 ) page: 3247 - 3256   2020.9

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    DOI: 10.1245/s10434-020-08431-8

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  96. Systemic Inflammation Score as a Predictor of Pneumonia after Radical Resection of Gastric Cancer: Analysis of a Multi-Institutional Dataset. Reviewed International journal

    Michita Shoka, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

    Digestive surgery   Vol. 37 ( 5 ) page: 401 - 410   2020.9

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    BACKGROUND: Curative treatment for gastric cancer (GC) comprising gastrectomy with systematic lymph node dissection can result in postoperative complications. Postoperative pneumonia is sometimes fatal, like surgery-related complications such as anastomotic leakage. In this retrospective study, we analyzed a multi-institutional collaborative dataset with the aim of identifying predictors of postgastrectomy pneumonia. METHODS: From a retrospective database of 3,484 patients who had undergone gastrectomy for GC at nine Japanese institutions between 2010 and 2014, 1,415 patients who met all eligibility criteria were identified as eligible for analysis. Predictive values of 31 candidate variables for postoperative pneumonia were assessed. RESULTS: Forty-two patients (3.0%) had grade II or higher postoperative pneumonia. Preoperative systemic inflammation score (SIS) had the greatest area under the curve (0.655) for predicting postoperative pneumonia (optimal cutoff value = 2). The odds ratio (OR) of high SISs associated with postoperative pneumonia was 3.10 (95% confidence interval [CI], 1.54-6.07; p < 0.001). Multivariate binomial logistic analysis identified high SIS as an independent risk factor for postoperative pneumonia (OR, 2.31; 95% CI, 1.19-4.48; p = 0.013). A forest plot revealed that ORs of high SISs were highest in female patients. CONCLUSIONS: Our findings indicate that the preoperative SIS may serve as a simple predictor of postgastrectomy pneumonia, assisting physicians' efforts to take preventive measures against this complication.

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  97. Therapeutic monoclonal antibody targeting of neuronal pentraxin receptor to control metastasis in gastric cancer. Reviewed International journal

    Mitsuro Kanda, Dai Shimizu, Koichi Sawaki, Shunsuke Nakamura, Shinichi Umeda, Takashi Miwa, Haruyoshi Tanaka, Chie Tanaka, Masamichi Hayashi, Yohei Iguchi, Suguru Yamada, Masahisa Katsuno, Yasuhiro Kodera

    Molecular cancer   Vol. 19 ( 1 ) page: 131 - 131   2020.8

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    BACKGROUND: Controlling metastasis is essential for improving the prognosis of patients with gastric cancer (GC). Here, we aimed to identify a molecule required for GC metastasis and to investigate its potential utility as a target for the development of therapeutic antibodies (Abs). METHODS: Transcriptome and bioinformatics analyses of human GC cell lines identified the neuronal pentraxin receptor (NPTXR) as a candidate molecule. NPTXR function was probed by modulating its expression in GC cells and assessing the effects on intracellular signaling and malignant behaviors in vitro and in mouse xenograft models. We also generated anti-NPTXR Abs and Nptxr-/- mice, and assessed the clinical significance of NPTXR expression in GC specimens. RESULTS: NPTXR mRNA expression in clinical specimens was associated with disease progression and was significantly higher in tissues from GC patients with distant metastasis compared with those without. NPTXR regulated expression of genes involved in metastatic behaviors as well as activation of the PI3K-AKT-mTOR, FAK-JNK, and YAP signaling pathways. NPTXR silencing promoted caspase-mediated apoptosis and attenuated GC cell proliferation, cell cycle progression, migration, invasion, adhesion, stem cell-like properties, and resistance to 5-fluorouracil in vitro, and also inhibited the tumorigenicity of GC cells in vivo. Anti-NPTXR Abs inhibited GC peritoneal metastasis in mice. Nptxr-/- mice showed no abnormalities in reproduction, development, metabolism, or motor function. CONCLUSIONS: NPTXR plays an essential role in controlling the malignant behavior of GC cells in vitro and in vivo. NPTXR-targeting Abs may thus have utility as novel diagnostic tools and/or treatment modalities for GC.

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  98. Surveillance of Esophageal Cancer in the Republic of Uzbekistan from 2000 to 2018. Reviewed

    Yusupbekov A, Kanda M, Usmanov B, Tuychiev O, Baymakov S, Sakamoto J, Yusupbekov A

    Asian Pacific journal of cancer prevention : APJCP   Vol. 21 ( 8 ) page: 2281 - 2285   2020.8

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    DOI: 10.31557/APJCP.2020.21.8.2281

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  99. The impact of cancer stem cell markers in the tissues of pancreatic ductal adenocarcinoma for prognosis after surgical resections Reviewed

    Inokawa Yoshikuni, Yamada Suguru, Hayashi Masamichi, Sunagawa Yuki, Sonohara Fuminori, Takami Hideki, Hattori Norifumi, Kanda Mitsuro, Kobayashi Daisuke, Tanaka Chie, Nakayama Goro, Koike Masahiko, Kodera Yasuhiro

    CANCER RESEARCH   Vol. 80 ( 16 )   2020.8

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    DOI: 10.1158/1538-7445.AM2020-6016

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  100. Survival times are similar among patients with peritoneal, hematogenous, and nodal recurrences after curative resections for gastric cancer. Reviewed International journal

    Koichi Sawaki, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

    Cancer medicine   Vol. 9 ( 15 ) page: 5392 - 5399   2020.8

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    BACKGROUND: The three dominant recurrence patterns of gastric cancer are peritoneal, hematogenous, and nodal recurrence. Correlation between initial recurrence site and prognosis is poorly understood, particularly after standardization of postoperative S-1 adjuvant chemotherapy. METHODS: We analyzed a multi-institutional database of 3484 patients who underwent gastrectomy for gastric cancer between 2010 and 2014. Patients who experienced recurrences after curative gastrectomy classified into peritoneal, hematogenous, or nodal recurrence groups, according to their initial recurrence sites, and their prognoses were compared. RESULTS: We included 313 patients in the analysis, of whom 190 patients (63%) were treated with postoperative adjuvant chemotherapy. Pathological disease states were stage I: n = 20 (6%), stage II: n = 62 (20%), and stage III: n = 231 (74%). Patients were categorized into groups by peritoneal (n = 127), hematogenous (n = 123), and nodal (n = 63) recurrence. The peritoneal recurrence group tended to have longer recurrence-free survival, but shorter post-recurrence survival, than the other two groups. Median disease-specific survival after curative resection by group were peritoneal: 25.8 months, hematogenous: 29.0 months, and nodal: 27.8 months (peritoneal vs hematogenous, P = .152; hematogenous vs nodal, P = .955; peritoneal vs nodal, P = .213). CONCLUSIONS: Prognoses after curative resection for gastric cancer were similar among patients with peritoneal, hematogenous, or nodal recurrences.

    DOI: 10.1002/cam4.3208

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  101. ETNK2のアポトーシス調節を介した胃癌細胞肝転移への関与 Reviewed

    三輪 高嗣, 神田 光郎, 田中 千恵, 小林 大介, 清水 大, 園原 史訓, 高見 秀樹, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: SF - 5   2020.8

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  102. 当院における消化器外科領域のCALNA参入と現状について Reviewed

    宮田 一志, 深谷 昌秀, 山崎 健太, 石井 健太, 冨永 健太, 西村 康大, 小池 聖彦, 小林 大介, 田中 千恵, 神田 光郎, 清水 大, 佐藤 敏, 中西 香企, 江畑 智希, 小寺 泰弘, 梛野 正人

    日本外科学会定期学術集会抄録集   Vol. 120回   page: SF - 7   2020.8

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  103. 当科におけるUnresectable膵癌治療の検討 Reviewed

    加藤 吉康, 山田 豪, 高見 秀樹, 園原 史訓, 猪川 祥邦, 林 真路, 服部 憲史, 神田 光郎, 小林 大介, 田中 千恵, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: SF - 4   2020.8

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  104. 幽門側胃切除術後の再建法が術後合併症に及ぼす影響 B-I法とR-Y法の比較 Reviewed

    中西 香企, 神田 光郎, 伊藤 誠二, 望月 能成, 寺本 仁, 石榑 清, 村井 俊文, 浅田 崇洋, 石山 聡治, 松下 英信, 清水 大, 田中 千恵, 小林 大介, 藤原 道隆, 室谷 健太, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: SF - 6   2020.8

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  105. 幽門側胃切除術後の再建法が術後合併症に及ぼす影響 B-I法とR-Y法の比較 Reviewed

    中西 香企, 神田 光郎, 伊藤 誠二, 望月 能成, 寺本 仁, 石榑 清, 村井 俊文, 浅田 崇洋, 石山 聡治, 松下 英信, 清水 大, 田中 千恵, 小林 大介, 藤原 道隆, 室谷 健太, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: SF - 6   2020.8

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  106. 大腸癌初回肝転移手術後の早期再発予測因子の検討 Reviewed

    林 真路, 山田 豪, 高見 秀樹, 猪川 祥邦, 園原 史訓, 砂川 祐輝, 田中 伸孟, 栗本 景介, 加藤 吉康, 中川 暢彦, 鈴木 雄之典, 神田 光郎, 田中 千恵, 小林 大介, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: DP - 4   2020.8

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  107. 多施設共同胃癌データベースを利用した胃切除術後肺炎発生に関する予測因子の検討 Reviewed

    荘加 道太, 神田 光郎, 伊藤 誠二, 望月 能也, 寺本 仁, 石榑 清, 村井 俊文, 浅田 崇洋, 石山 聡治, 松下 英信, 田中 千恵, 小林 大介, 藤原 道隆, 室谷 健太, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: SF - 4   2020.8

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  108. 多施設共同胃癌データベースを利用した胃切除術後肺炎発生に関する予測因子の検討 Reviewed

    荘加 道太, 神田 光郎, 伊藤 誠二, 望月 能也, 寺本 仁, 石榑 清, 村井 俊文, 浅田 崇洋, 石山 聡治, 松下 英信, 田中 千恵, 小林 大介, 藤原 道隆, 室谷 健太, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: SF - 4   2020.8

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  109. 切除不能胃癌に対する集学的治療としてのconversion surgeryの適応について Reviewed

    小林 大介, 神田 光郎, 田中 千恵, 清水 大, 園原 史訓, 猪川 祥邦, 高見 秀樹, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: SF - 3   2020.8

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  110. 傾向スコアマッチングを用いた後期高齢者における食道亜全摘術の短期成績と術前免疫栄養因子の検討 Reviewed

    神田 光郎, 小池 聖彦, 清水 大, 田中 千恵, 小林 大介, 園原 史訓, 猪川 祥邦, 高見 秀樹, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: DP - 4   2020.8

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  111. Ivor Lewis手術は超高齢者に対する低侵襲手術となり得るか? Reviewed

    小池 聖彦, 神田 光郎, 高見 秀樹, 服部 憲史, 林 真路, 田中 千恵, 山田 豪, 中山 吾郎, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: DP - 6   2020.8

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  112. Initial systemic therapy時代における高齢者膵癌集学的治療の意義と限界 Reviewed

    園原 史訓, 山田 豪, 高見 秀樹, 猪川 祥邦, 林 真路, 清水 大, 服部 憲史, 神田 光郎, 田中 千恵, 小林 大介, 中山 吾郎, 小池 聖彦, 藤原 道隆, 藤井 努, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: SF - 6   2020.8

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  113. 膵癌に対する膵頭十二指腸切除術の分子生物学的なsurgical marginの評価 Reviewed

    砂川 祐輝, 山田 豪, 林 真路, 高見 秀樹, 猪川 祥邦, 園原 史訓, 栗本 景介, 田中 伸孟, 加藤 吉康, 中川 暢彦, 鈴木 雄之典, 神田 光郎, 田中 千恵, 小林 大介, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: SF - 2   2020.8

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  114. 高齢者胃切除手術症例における前向き高齢者機能評価 Reviewed

    田中 千恵, 神田 光郎, 猪川 祥邦, 小林 大介, 清水 大, 園原 史訓, 高見 秀樹, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: SF - 4   2020.8

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  115. 食道癌術前化学療法中にRenal Salt-Wasting Syndromeを生じた1例 Reviewed

    山本 周平, 神田 光郎, 小池 聖彦, 高見 秀樹, 清水 大, 田中 千恵, 小林 大介, 園原 史訓, 猪川 祥邦, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: RS - 4   2020.8

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  116. 食道扁平上皮癌の術後長期予後因子としてのmodified systemic inflammation scoreの意義 Reviewed

    清水 大, 神田 光郎, 小池 聖彦, 園原 史訓, 高見 秀樹, 猪川 祥邦, 服部 憲史, 林 真路, 田中 千恵, 小林 大介, 山田 豪, 中山 吾郎, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: DP - 5   2020.8

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  117. 食道扁平上皮癌におけるMAGE-D4蛋白の発現、機能、予後の検討 Reviewed

    宇野 泰朗, 神田 光郎, 佐藤 雄亮, 清水 大, 梅田 晋一, 服部 憲史, 林 真路, 田中 千恵, 小林 大介, 山田 豪, 中山 吾郎, 小池 聖彦, 本山 悟, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: SF - 5   2020.8

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  118. 食道扁平上皮癌におけるKCNJ15遺伝子の機能解析と、その組織中発現における臨床的意義の検討 Reviewed

    中村 俊介, 神田 光郎, 小池 聖彦, 清水 大, 小林 大介, 田中 千恵, 園原 史訓, 高見 秀樹, 猪川 祥邦, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: DP - 8   2020.8

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  119. 食道亜全摘術後肺炎予測因子に関する検討 Reviewed

    澤木 康一, 神田 光郎, 小池 聖彦, 清水 大, 田中 千恵, 小林 大介, 園原 史訓, 服部 憲史, 猪川 祥邦, 高見 秀樹, 林 真路, 山田 豪, 中山 吾郎, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: SF - 4   2020.8

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  120. 術前CT画像を利用した膵内脂肪量と体組成による膵液瘻予測因子の検討 Reviewed

    田中 克仁, 山田 豪, 園原 史訓, 猪川 祥邦, 高見 秀樹, 服部 憲史, 林 真路, 神田 光郎, 田中 千恵, 小林 大介, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: SF - 1   2020.8

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  121. 膵頸部癌における臨床病理学的特徴 Reviewed

    栗本 景介, 山田 豪, 鈴木 雄之典, 中川 暢彦, 加藤 吉康, 田中 伸孟, 砂川 祐輝, 園原 史訓, 猪川 祥邦, 高見 秀樹, 林 真路, 神田 光郎, 田中 千恵, 中山 吾郎, 小池 聖彦, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: SF - 3   2020.8

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  122. 膵頭十二指腸切除術施行膵癌患者における周術期メインおよびリパクレオン投与の安全性と有用性 Reviewed

    中川 暢彦, 山田 豪, 多代 充, 栗本 景介, 園原 史訓, 清水 大, 猪川 祥邦, 高見 秀樹, 服部 憲史, 林 真路, 神田 光郎, 田中 千恵, 小林 大介, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: DP - 5   2020.8

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  123. 膵頭十二指腸切除術における胆管空腸吻合部狭窄のリスクファクターに関する検討 Reviewed

    鈴木 雄之典, 山田 豪, 園原 史訓, 猪川 祥邦, 高見 秀樹, 服部 憲史, 林 真路, 神田 光郎, 小林 大介, 田中 千恵, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: DP - 4   2020.8

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  124. 膵癌組織における癌幹細胞マーカー発現が切除後予後に与える影響についての検討 Reviewed

    猪川 祥邦, 山田 豪, 林 真路, 砂川 祐輝, 園原 史訓, 高見 秀樹, 服部 憲史, 神田 光郎, 小林 大介, 田中 千恵, 中山 吾郎, 小池 聖彦, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: DP - 5   2020.8

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  125. ASO Author Reflections: KCNJ15 Expression and Malignant Behavior of Esophageal Squamous Cell Carcinoma Reviewed

    Nakamura Shunsuke, Kanda Mitsuro, Kodera Yasuhiro

    ANNALS OF SURGICAL ONCOLOGY   Vol. 27 ( 7 ) page: 2569 - 2570   2020.7

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    DOI: 10.1245/s10434-020-08337-5

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  126. KCNJ15 Expression and Malignant Behavior of Esophageal Squamous Cell Carcinoma. Reviewed International journal

    Shunsuke Nakamura, Mitsuro Kanda, Masahiko Koike, Dai Shimizu, Shinichi Umeda, Norifumi Hattori, Masamichi Hayashi, Chie Tanaka, Daisuke Kobayashi, Suguru Yamada, Kenji Omae, Yasuhiro Kodera

    Annals of surgical oncology   Vol. 27 ( 7 ) page: 2559 - 2568   2020.7

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    BACKGROUND: We aimed to clarify the role of potassium voltage-gated channel subfamily J member 15 (KCNJ15) in esophageal squamous cell carcinoma (ESCC) cells and its potential as a prognosticator in ESCC patients. METHODS: KCNJ15 transcription levels were evaluated in 13 ESCC cell lines and polymerase chain reaction (PCR) array analysis was conducted to detect coordinately expressed genes with KCNJ15. The biological functions of KCNJ15 in cell invasion, proliferation, migration, and adhesion were validated through small interfering RNA-mediated knockdown experiments. Cell proliferation was further evaluated through the forced expression experiment. KCNJ15 expression was detected in 200 ESCC tissues by quantitative real-time reverse transcription PCR (qRT-PCR) and analyzed in 64 representative tissues by immunohistochemistry. Correlations between KCNJ15 expression levels and clinicopathological features were also analyzed. RESULTS: The KCNJ15 expression levels varied widely in ESCC cell lines and correlated with COL3A1, JAG1, and F11R. Knockdown of KCNJ15 expression significantly repressed cell invasion, proliferation, and migration of ESCC cells in vitro. Furthermore, overexpression of KCNJ15 resulted in increased cell proliferation. Patients were stratified using the cut-off value of KCNJ15 messenger RNA (mRNA) levels in 200 ESCC tissues using receiver operating characteristic curve analysis; the high KCNJ15 expression group had significantly shorter overall and disease-free survival times. In multivariable analysis, high expression of KCNJ15 was identified as an independent poor prognostic factor. Staining intensity of in situ KCNJ15 protein expression tended to be associated with KCNJ15 mRNA expression levels. CONCLUSIONS: KCNJ15 is involved in aggressive tumor phenotypes of ESCC cells and its tissue expression levels may be useful as a prognosticator of patients with ESCC.

    DOI: 10.1245/s10434-019-08189-8

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  127. Propensity-score-matched analysis of a multi-institutional dataset to compare postoperative complications between Billroth I and Roux-en-Y reconstructions after distal gastrectomy. Reviewed

    Koki Nakanishi, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Dai Shimizu, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   Vol. 23 ( 4 ) page: 734 - 745   2020.7

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    BACKGROUND: Few well-controlled studies have compared postoperative complications between Billroth I (B-I) and Roux-en-Y (R-Y). The aim of the present study was to compare the incidence of overall and severe postoperative complications by reconstruction method after distal gastrectomy. METHODS: We performed a multi-institutional dataset study of patients who underwent distal gastrectomy with B-I or R-Y reconstruction from 2010 to 2014. Using propensity scores to strictly balance the significant variables, we compared postoperative complications between the techniques. RESULTS: After matching, we enrolled 1014 patients (n = 507 in each group). The incidence of postoperative complications in the R-Y group was significantly higher vs the B-I group (29% vs 17%, P < 0.0001). The incidence of intra-abdominal abscess (4.3% vs 1.8%, P = 0.0177), bowel obstruction (2.6% vs 0.6%, P = 0.0203), and delayed gastric emptying (5.3% vs 1.0%, P < 0.0001) in the R-Y group was significantly higher vs the B-I group, respectively; we saw no significant difference in leakage (3.4% vs 4.1%, P = 0.5084). The incidence of grade ≥ III severe postoperative complications in the R-Y group was significantly higher vs the B-I group (13% vs 7.1%, P = 0.0013). Multivariable analysis showed that R-Y reconstruction was a strong independent risk factor for overall postoperative complications (odds ratio 1.58, P = 0.0044) and grade ≥ III severe postoperative complications (odds ratio 1.75, P = 0.0127). A forest plot revealed that R-Y reconstruction was associated with a greater risk of both overall and grade ≥ III severe postoperative complications in any subgroups. CONCLUSIONS: R-Y reconstruction was associated with increasing overall postoperative complications, as well as severe postoperative complications.

    DOI: 10.1007/s10120-020-01048-6

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  128. Novel Prognostic Implications of DUPAN-2 in the Era of Initial Systemic Therapy for Pancreatic Cancer. Reviewed

    Sunagawa Y, Yamada S, Sato Y, Morimoto D, Sonohara F, Takami H, Inokawa Y, Hayashi M, Kanda M, Tanaka C, Kobayashi D, Nakayama G, Koike M, Fujiwara M, Fujii T, Kodera Y

    Annals of surgical oncology   Vol. 27 ( 6 ) page: 2081 - 2089   2020.6

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    DOI: 10.1245/s10434-019-07981-w

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  129. PRAME as a Potential Biomarker for Liver Metastasis of Gastric Cancer Reviewed

    Baba Hayato, Kanda Mitsuro, Sawaki Koichi, Umeda Shinichi, Miwa Takashi, Shimizu Dai, Tanaka Chie, Kobayashi Daisuke, Fujiwara Michitaka, Kodera Yasuhiro, Fujii Tsutomu

    ANNALS OF SURGICAL ONCOLOGY   Vol. 27 ( 6 ) page: 2071 - 2080   2020.6

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    DOI: 10.1245/s10434-019-07985-6

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  130. 集学的治療による病勢コントロール後に外腸骨リンパ節転移を切除しえた膵NETの1例 Reviewed

    鈴木 雄之典, 山田 豪, 高見 秀樹, 園原 史訓, 猪川 祥邦, 服部 憲史, 林 真路, 神田 光郎, 田中 千恵, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本消化器病学会東海支部例会プログラム抄録集   Vol. 132回   page: 55 - 55   2020.6

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  131. Fraser extracellular matrix complex subunit 1 promotes liver metastasis of gastric cancer. Reviewed

    Umeda S, Kanda M, Miwa T, Tanaka H, Tanaka C, Kobayashi D, Hayashi M, Yamada S, Nakayama G, Koike M, Kodera Y

    International journal of cancer   Vol. 146 ( 10 ) page: 2865 - 2876   2020.5

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    DOI: 10.1002/ijc.32705

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  132. Clinical impact of additional therapy for residual pancreatic cancer. Reviewed

    Yamada S, Sonohara F, Tashiro M, Murotani K, Takami H, Hayashi M, Kanda M, Tanaka C, Kobayashi D, Nakayama G, Koike M, Fujii T, Kodera Y

    Surgery today   Vol. 50 ( 5 ) page: 440 - 448   2020.5

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    DOI: 10.1007/s00595-019-01900-y

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  133. Is the measurement of drain amylase content useful for predicting pancreas-related complications after gastrectomy with systematic lymphadenectomy? Reviewed International journal

    Koki Nakanishi, Mitsuro Kanda, Junichi Sakamoto, Yasuhiro Kodera

    World journal of gastroenterology   Vol. 26 ( 14 ) page: 1594 - 1600   2020.4

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    Many studies investigating postoperative pancreatic fistula (POPF) after gastrectomy, including studies measuring drain amylase content (D-AMY) as a predictive factor have been reported. This article reviews previous studies and looks to the future of measuring D-AMY in patients after gastrectomy. The causes of pancreatic fluid leakage are; the parenchymal and/or thermal injury to the pancreas, and blunt injury to the pancreas by compression and retraction. Measurement of D-AMY to predict POPF has become common in clinical practice after pancreatic surgery and was later extended to the gastric surgery. Several studies have reported associations between D-AMY and POPF after gastrectomy, and the high value of D-AMY on postoperative day (POD) 1 was an independent risk factor. To improve both sensitivity and specificity, attempts have been made to enhance the predictive accuracy of factors on POD 1 as well as on POD 3 as combined markers. Although several studies have shown a high predictive ability of POPF, it has not necessarily been exploited in clinical practice. Many problems remain unresolved; ideal timing for measurement, optimal cut-off value, and means of intervention after prediction. Prospective clinical trial could be imperative in order to develop D-AMY measurement in common clinical practice for gastric surgery.

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  134. Detection of indocyanine green fluorescence to determine tumor location during laparoscopic gastrectomy for gastric cancer: Results of a prospective study.

    Tanaka C, Kanda M, Funasaka K, Miyahara R, Murotani K, Tanaka Y, Takeda S, Kobayashi D, Hirooka Y, Fujiwara M, Goto H, Kodera Y

    Asian journal of endoscopic surgery   Vol. 13 ( 2 ) page: 160 - 167   2020.4

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    INTRODUCTION: In laparoscopic gastrectomy, a method to locate the margin of an early-stage cancerous lesion that is invisible from the serosal surface and impalpable during laparoscopic procedures is needed to determine an appropriate transection line. We conducted a prospective study to develop a new marking method using preoperative submucosal injection of indocyanine green (ICG). METHODS: Patients undergoing laparoscopic gastrectomy for T1 gastric cancer were recruited. The first 11 patients comprised the learning set and the subsequent 18 patients the validation set. ICG was endoscopically injected in the submucosal layer of the stomach approximately 1 cm away from the tumor edge 1 or 3 days before surgery. The diameters of the visualized ICG were compared with those of a conventional marking method using India ink in 10 historical controls. RESULTS: In the learning set, the optimal amount of ICG was determined to be 0.1 mL at a concentration of 0.5 mg/mL. In the validation set, the same procedure was repeated. No technical problems or adverse reactions related to ICG injection were observed. In all cases, ICG was successfully detected, and negative surgical margins were pathologically confirmed. The mean long diameter of the visualized ICG fluorescence measured at the mucosal surface of the stomach was significantly smaller in the current study than in the historical controls in whom India ink was used (21 vs 52 mm, P < 0.0001). CONCLUSIONS: The preoperative submucosal ICG marking was safely performed and successfully detected without excessive blurring during laparoscopic gastrectomy.

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  135. Exploration of Exosomal Micro RNA Biomarkers Related to Epithelial-to-Mesenchymal Transition in Pancreatic Cancer. Reviewed International journal

    Fuminori Sonohara, Suguru Yamada, Shigeomi Takeda, Masamichi Hayashi, Masaya Suenaga, Yuki Sunagawa, Mitsuru Tashiro, Hideki Takami, Mitsuro Kanda, Chie Tanaka, Daisuke Kobayashi, Goro Nakayama, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera

    Anticancer research   Vol. 40 ( 4 ) page: 1843 - 1853   2020.4

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    BACKGROUND/AIM: Epithelial-to-mesenchymal transition (EMT) plays important roles in cancer progression. This study aimed to identify the exosomal miRNA (exo-miRNA) profiles related to the EMT status in pancreatic cancer (PC). MATERIALS AND METHODS: Comprehensive exo-miRNA-expression profiles in the culture media of PC cell lines were analyzed through microarray technology. The identified miRNAs were analyzed to investigate their clinical implication using The Cancer Genome Atlas (TCGA) dataset and clinical samples. RESULTS: We prioritized 291 exo-miRNAs differentially expressed between epithelial and mesenchymal cell types. Among them, survival analysis based on the TCGA dataset revealed that mir-196b and mir-204 significantly stratify the prognosis of PC cases. In addition, analysis of cell lines indicated miR-196b-3p as a mesenchymal marker and miR-204-3p as an epithelial marker. Finally, we demonstrated that miR-196b-3p and miR-204-3p in serum exosomes were differentially expressed among intraductal papillary mucinous neoplasms, mucinous cystic neoplasms, and PC. CONCLUSION: Serum exo-miRNA biomarkers potentially identify the pancreatic tumor status through less-invasive methods.

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  136. Optimized Cutoff Value of Serum Squamous Cell Carcinoma Antigen Concentration Accurately Predicts Recurrence After Curative Resection of Squamous Cell Carcinoma of the Esophagus. Reviewed

    Kanda M, Koike M, Shimizu D, Tanaka C, Kobayashi D, Hattori N, Hayashi M, Omae K, Yamada S, Nakayama G, Kodera Y

    Annals of surgical oncology   Vol. 27 ( 4 ) page: 1233 - 1240   2020.4

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  137. Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study Reviewed

    Okada Norio, Iwama Shintaro, Okuji Takayuki, Kobayashi Tomoko, Yasuda Yoshinori, Wada Eri, Onoue Takeshi, Goto Motomitsu, Sugiyama Mariko, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Suga Hidetaka, Banno Ryoichi, Hase Tetsunari, Morise Masahiro, Kanda Mitsuro, Yokota Kenji, Hashimoto Naozumi, Ando Masahiko, Fujimoto Yasushi, Nagino Masato, Kodera Yasuhiro, Fujishiro Mitsuhiro, Hibi Hideharu, Sone Michihiko, Kiyoi Hitoshi, Gotoh Momokazu, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Arima Hiroshi

    BRITISH JOURNAL OF CANCER   Vol. 122 ( 6 ) page: 771 - 777   2020.3

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  138. Clinical Implications of Naples Prognostic Score in Patients with Resected Pancreatic Cancer. Reviewed International journal

    Nobuhiko Nakagawa, Suguru Yamada, Fuminori Sonohara, Hideki Takami, Masamichi Hayashi, Mitsuro Kanda, Daisuke Kobayashi, Chie Tanaka, Goro Nakayama, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera

    Annals of surgical oncology   Vol. 27 ( 3 ) page: 887 - 895   2020.3

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    BACKGROUND: Nutritional and immunological statuses are attracting increasing attention for their ability to predict surgical outcomes in various cancers. The Naples prognostic score (NPS) consists of the serum albumin level, total cholesterol level, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio and could be useful for predicting survival. PATIENTS AND METHODS: We retrospectively analyzed 196 patients with pancreatic cancer who underwent curative R0/R1 resection with a surgery-first strategy between June 2003 and August 2016. The NPS of the patients was calculated from preoperative data, and the patients were then divided into three groups based on their NPS. Clinicopathological characteristics, surgical outcomes, and long-term survival were compared, and multivariate analysis of overall survival was conducted. RESULTS: Of a total of 196 patients, 22 were classified into group 0 (NPS 0), 113 into group 1 (NPS 1 or 2), and 61 into group 2 (NPS 3 or 4). Median survival time was 103.4 months in group 0, 33.3 months in group 1, and 21.3 months in group 2. Significant survival differences were observed among the 3 groups (group 1 vs. 2, group 0 vs. 2, P = 0.0380, P = 0.0022, respectively). On multivariate analysis, NPS was identified as an independent prognostic factor [hazard ratio (HR) = 1.78; P = 0.0131]; however, there were no significant differences in the incidence of postoperative morbidity among the NPS groups. CONCLUSIONS: The NPS could be an easy scoring system and an independent preoperative predictor of survival.

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  139. Preoperative predictors of postoperative complications after gastric cancer resection (vol 50, pg 3, 2020) Reviewed

    Kanda Mitsuro

    SURGERY TODAY   Vol. 50 ( 3 ) page: 321 - 321   2020.3

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    DOI: 10.1007/s00595-019-01948-w

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  140. Association between Lymphovascular Invasion and Recurrence in Patients with pT1N+ or pT2-3N0 Gastric Cancer: a Multi-institutional Dataset Analysis. Reviewed International journal

    Keizo Fujita, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

    Journal of gastric cancer   Vol. 20 ( 1 ) page: 41 - 49   2020.3

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    Purpose: Patients with pathological stage T1N+ or T2-3N0 gastric cancer may experience disease recurrence following curative gastrectomy. However, the current Japanese Gastric Cancer Treatment Guidelines do not recommend postoperative adjuvant chemotherapy for such patients. This study aimed to identify the prognostic factors for patients with pT1N+ or pT2-3N0 gastric cancer using a multi-institutional dataset. Materials and Methods: We retrospectively analyzed the data obtained from 401 patients with pT1N+ or pT2-3N0 gastric cancer who underwent curative gastrectomy at 9 institutions between 2010 and 2014. Results: Of the 401 patients assessed, 24 (6.0%) experienced postoperative disease recurrence. Multivariate analysis revealed that age ≥70 years (hazard ratio [HR], 2.62; 95% confidence interval [CI], 1.09-7.23; P=0.030) and lymphatic and/or venous invasion (lymphovascular invasion (LVI): HR, 7.88; 95% CI, 1.66-140.9; P=0.005) were independent prognostic factors for poor recurrence-free survival. There was no significant association between LVI and the site of initial recurrence. Conclusions: LVI is an indicator of poor prognosis in patients with pT1N+ or pT2-3N0 gastric cancer.

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  141. Serum levels of ANOS1 serve as a diagnostic biomarker of gastric cancer: a prospective multicenter observational study. Reviewed

    Mitsuro Kanda, Yun-Suhk Suh, Do Joong Park, Chie Tanaka, Sang-Hoon Ahn, Seong-Ho Kong, Hyuk-Joon Lee, Daisuke Kobayashi, Michitaka Fujiwara, Hideaki Shimada, BeLong Cho, Kenta Murotani, Hyung-Ho Kim, Han-Kwang Yang, Yasuhiro Kodera

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   Vol. 23 ( 2 ) page: 203 - 211   2020.3

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    BACKGROUND: Development of high-performance serum biomarkers will likely improve treatment outcomes of patients with gastric cancer (GC). We previously identified the candidate serum markers, anosmin 1 (ANOS1), dihydropyrimidinase-like 3 (DPYSL3), and melanoma-associated antigen D2 (MAGE-D2) and evaluated their clinical significance through a single-center retrospective analysis. Here we conducted a prospective multicenter observational study aimed at validating the diagnostic performance of these potential markers. METHODS: We analyzed serum levels before and after surgery of the three potential biomarkers in patients with GC and healthy volunteers. Quantification of serum and GC tissue levels was performed using an ELISA. RESULTS: Area under the curve (AUC) values that discriminated patients with GC from healthy controls were - 0.7058, 0.6188, and 0.5031 for ANOS1, DPYSL3, and MAGED2, respectively. The sensitivity and specificity of the ANOS1 assay were 0.36 and 0.85, respectively. The AUC value of ANOS1 that discriminated patients with stage I GC from healthy controls was 0.7131. Serum ANOS1 levels were significantly elevated in patients with stage I GC compared with those of healthy controls (median 1179 ng/ml and 461 ng/ml, respectively, P < 0.0001) and decreased after resection of primary GC lesions (P < 0.0001). The combination of serum ANOS1 and DPYSL3 levels increased the AUC value that discriminated patients with GC from healthy controls. Serum levels of ANOS1 did not significantly correlate with those of carcinoembryonic antigen, carbohydrate antigen 19-9, or other markers of inflammation. CONCLUSIONS: Serum levels of ANOS1 may serve as a useful diagnostic tool for managing GC.

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  142. FGFR1は胃癌細胞のEMTを促進し腹膜播種形成に関連する Reviewed

    清水 大, 園原 史訓, 高見 秀樹, 猪川 祥邦, 服部 憲史, 林 真路, 神田 光郎, 田中 千恵, 小林 大介, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 三森 功士, 小寺 泰弘

    日本胃癌学会総会記事   Vol. 92回   page: 393 - 393   2020.3

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  143. 今後の胃癌バイオマーカー 胃癌腹膜播種再発を予測する腹膜洗浄液中の分子バイオマーカー(Upcoming biomarkers for gastric cancer Molecular biomarkers in peritoneal lavages to predict the peritoneal recurrences of gastric cancer) Reviewed

    Kanda Mitsuro, Nakanishi Koki, Tanaka Chie, Kobayashi Daisuke, Shimizu Dai, Sonohara Fuminori, Takami Hideki, Inokawa Yoshikuni, Hattori Norifumi, Hayashi Masamichi, Yamada Suguru, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    日本胃癌学会総会記事   Vol. 92回   page: 233 - 233   2020.3

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  144. FGFR1は胃癌細胞のEMTを促進し腹膜播種形成に関連する Reviewed

    清水 大, 園原 史訓, 高見 秀樹, 猪川 祥邦, 服部 憲史, 林 真路, 神田 光郎, 田中 千恵, 小林 大介, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 三森 功士, 小寺 泰弘

    日本胃癌学会総会記事   Vol. 92回   page: 393 - 393   2020.3

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  145. 胃癌手術のエビデンスと実際のデータ 基礎 幽門側胃切除後のBillroth I再建法とRoux-en-Y再建法に関する術後合併症の比較(Evidences and real world data of gastric cancer surgery: Basic Billroth I vs Roux-en-Y after distal gastrectomy in postoperative complications) Reviewed

    Nakanishi Koki, Kanda Mitsuro, Ito Seiji, Mochizuki Yoshinari, Teramoto Hitoshi, Ishigure Kiyoshi, Murai Toshifumi, Asada Takahiro, Ishiyama Akiharu, Matsushita Hidenobu, Shimizu Dai, Tanaka Chie, Kobayashi Daisuke, Fujiwara Michitaka, Kodera Yasuhiro

    日本胃癌学会総会記事   Vol. 92回   page: 214 - 214   2020.3

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  146. 高齢者胃切除手術症例における自立度の転帰 Reviewed

    田中 千恵, 神田 光郎, 猪川 祥邦, 清水 大, 園原 史訓, 小林 大介, 高見 秀樹, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本胃癌学会総会記事   Vol. 92回   page: 251 - 251   2020.3

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  147. 高齢者胃切除手術症例における自立度の転帰 Reviewed

    田中 千恵, 神田 光郎, 猪川 祥邦, 清水 大, 園原 史訓, 小林 大介, 高見 秀樹, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本胃癌学会総会記事   Vol. 92回   page: 251 - 251   2020.3

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  148. Predictive value of the modified systemic inflammation score in patients undergoing curative resection of squamous cell carcinoma of the esophagus Reviewed

    Kanda Mitsuro, Koike Masahiko, Shimizu Dai, Tanaka Chie, Kobayashi Daisuke, Sonohara Fuminori, Takami Hideki, Inokawa Yoshikuni, Hattori Norifumi, Hayashi Masamichi, Yamada Suguru, Nakayama Goro, Fujiwara Michitaka, Kodera Yasuhiro

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 38 ( 4 )   2020.2

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  149. Propensity-score-matched analysis of a multi-institutional dataset to compare the postoperative complications after distal gastrectomy between Billroth I and Roux-en-Y Reviewed

    Nakanishi Koki, Kanda Mitsuro, Ito Seiji, Mochizuki Yoshinari, Teramoto Hitoshi, Ishigure Kiyoshi, Mmurai Toshifumi, Asada Takahiro, Ishiyama Akiharu, Matsushita Hidenobu, Shimizu Dai, Tanaka Chie, Kobayashi Daisuke, Fujiwara Michitaka, Kodera Yasuhiro

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 38 ( 4 )   2020.2

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  150. A prospective trial to evaluate treatment effects of a β-hydroxy-β-methylbutyrate containing nutrient for leakage at the anastomotic site after esophagectomy. Reviewed

    Mitsuro Kanda, Masahiko Koike, Masahide Fukaya, Kazushi Miyata, Chie Tanaka, Daisuke Kobayashi, Masamichi Hayashi, Suguru Yamada, Goro Nakayama, Kenta Murotani, Michitaka Fujiwara, Masato Nagino, Yasuhiro Kodera

    Nagoya journal of medical science   Vol. 82 ( 1 ) page: 33 - 37   2020.2

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    Anastomotic leakage after esophagectomy is associated with prolonged hospitalization and increased medical cost. Additionally, it sometimes leads to a fatal condition and impaired postoperative quality of life. During the process of wound healing, β-hydroxy-β-methylbutyrate (HMB) is important for collagen biosynthesis. An open-label prospective intervention trial has been designed to evaluate the treatment effect of an enteral nutrient containing HMB with arginine and glutamine (Abound, Abbott Japan Co., Ltd.) for leakage at the anastomotic site after esophagectomy. Patients in whom leakage at the anastomotic site developed within 14 days after esophagectomy are eligible and Abound (24 g) is administered for 14 days through an enteral feeding tube. The target sample size is 10. The primary endpoint is duration between diagnosis and cure of leakage. Surgical procedure, safety, length of fasting, drainage placement and hospital stay, and nutritional status are determined as secondary endpoints. A historical control consisting of 20 patients who had leakage at the anastomotic site after esophagectomy between 2005 and 2018 at Nagoya University Hospital is compared with enrolled patients.

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  151. Preoperative six-minute walk distance as a predictor of postoperative complication in patients with esophageal cancer.

    Inoue T, Ito S, Kanda M, Niwa Y, Nagaya M, Nishida Y, Hasegawa Y, Koike M, Kodera Y

    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus   Vol. 33 ( 2 )   2020.2

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  152. Preoperative predictors of postoperative complications after gastric cancer resection Reviewed

    Kanda Mitsuro

    SURGERY TODAY   Vol. 50 ( 1 ) page: 3 - 11   2020.1

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    DOI: 10.1007/s00595-019-01877-8

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  153. The Significance of Molecular Biomarkers on Clinical Survival Outcome Differs Depending on Colon Cancer Sidedness. Reviewed International journal

    Sho Hirabayashi, Masamichi Hayashi, Goro Nakayama, Shinji Mii, Norifumi Hattori, Hiroshi Tanabe, Mitsuro Kanda, Chie Tanaka, Daisuke Kobayashi, Suguru Yamada, Masahiko Koike, Michitaka Fujiwara, Masahide Takahashi, Yasuhiro Kodera

    Anticancer research   Vol. 40 ( 1 ) page: 201 - 211   2020.1

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    BACKGROUND/AIM: This retrospective study focused on the correlation between molecular markers and prognostic outcomes of colon cancer patients depending on sidedness. MATERIALS AND METHODS: A total of 117 stage I-III colon cancer patients who underwent colectomy were enrolled. Novel methylation markers (KIF1A, PAX5 and VGF) were selected for epigenetic evaluation and p53 and ERCC1 protein expression was examined for the investigation of genetic alterations. RESULTS: High frequency of methylation was observed in 68.2% of right-sided and 39.7% of left-sided colon cancer cases (p=0.004). Abnormal p53 was identified in 52.3% of right-sided and 75.3% of left-sided cases (p=0.015). In right-sided cases, highly methylated genes demonstrated significantly favorable disease-free survival (p=0.049). Regarding left-sided cases, advanced T stage (p=0.028) and abnormal p53 (p=0.028) were revealed to be significant predictive factors of the disease-free survival outcome. CONCLUSION: Molecular alterations, as significant prognostic factors, might differ depending on the sidedness of colon cancers.

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  154. Phase I Study of Intraperitoneal Administration of Paclitaxel Combined with S-1 Plus Cisplatin for Gastric Cancer with Peritoneal Metastasis. Reviewed International journal

    Kobayashi D, Ishigami H, Kanda M, Tanaka C, Yamaguchi H, Kitayama J, Kodera Y

    Oncology   Vol. 98 ( 1 ) page: 48 - 52   2020.1

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    INTRODUCTION: Intraperitoneal (IP) chemotherapy is a promising treatment option for gastric cancer (GC) with peritoneal metastasis (PM). Recently, superiority of IP administration of paclitaxel (PTX) combined with S-1 and intravenous PTX over conventional systemic chemotherapy was suggested in a phase III study, although the difference in overall survival did not reach statistical significance in the primary analysis. Thus, attempts to combine IP PTX with other systemic therapies with higher efficacy are warranted. We designed a new regimen combining IP PTX with S-1 plus cisplatin (SP), which is regarded as the standard first-line treatment for metastatic GC in Japan, and subsequently carried out a dose-escalation study. METHODS: The combination was a 5-weekly regimen. IP PTX was to be administered on days 1, 8, and 22 with an initial dose of 15 mg/m2 at level 1 and 20 mg/m2 at level 2. S-1 was to be administered orally at a fixed dose of 80 mg/m2 b.i.d. for 21 days followed by a -14-day rest. Cisplatin was to be administered intravenously at a dose of 60 mg/m2 on day 8. Dose-limiting toxicities (DLTs) were defined as grade 4 leukopenia, grade 3 (G3) febrile neutropenia, G3 thrombocytopenia, and G3 nonhematological toxicity. RESULTS: A total of 9 patients with macroscopic PM were enrolled. No DLTs were observed among the 3 patients at level 1 and 6 patients at level 2. No adverse events or technical problems associated with the IP administration were observed. Consequently, the maximum-tolerated dose was not reached, and the dose for further clinical trials of IP PTX was determined as 20 mg/m2. As for efficacy, peritoneal lavage cytology turned negative after the first course in 4 of 7 patients who had positive cytology before treatment. CONCLUSION: The present study determined the dose for further clinical trials of IP PTX to be 20 mg/m2, when combined with the 5-weekly SP regimen.

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  155. Prognosis After Laparoscopic Gastrectomy in Patients with Pathological Stage II or III Gastric Cancer Who Were Preoperatively Diagnosed with Clinical Stage I: Propensity Score Matching Analysis of a Multicenter Dataset. Reviewed International journal

    Yuki Ito, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

    Annals of surgical oncology   Vol. 27 ( 1 ) page: 268 - 275   2020.1

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    BACKGROUND: Laparoscopic gastrectomy (LG) is a standard approach for patients with clinical stage I gastric cancer in East Asia; however, following surgery, these patients may be pathologically diagnosed with stage II or III cancer. The prognosis of patients with gastric cancer migration from clinical stage I to pathological stage II or III after LG has not been completely clarified. METHODS: To compare the prognosis following LG and open gastrectomy (OG) in patients with pathological stage II or III gastric cancer who were preoperatively diagnosed with stage I cancer, we conducted a retrospective analysis using a multicenter dataset comprising details of 3480 patients who underwent gastrectomy between 2010 and 2014 at nine participating institutions. We used propensity score matching to reduce selection bias. RESULTS: After propensity score matching, 146 patients were finally selected. There were no significant differences in the number of dissected lymph nodes. Morbidity rates, length of postoperative hospital stay, and time between surgery and initiation of adjuvant chemotherapy were comparable between the two groups. Moreover, there were no significant differences in the overall, disease-specific, and relapse-free survival rates between the LG and OG groups. The LG group tended to have more patients with hematogenous recurrence, whereas the OG group tended to have more patients with peritoneal recurrence. CONCLUSIONS: Our multicenter dataset analysis indicated that the prognosis of patients with gastric cancer migration from clinical stage I to pathological stage II or III was independent of the surgical approach.

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  156. Phase II study of capecitabine plus oxaliplatin (CapOX) as adjuvant chemotherapy for locally advanced rectal cancer (CORONA II). Reviewed

    Norifumi Hattori, Goro Nakayama, Keisuke Uehara, Toshisada Aiba, Kiyoshi Ishigure, Eiji Sakamoto, Yuichiro Tojima, Mitsuro Kanda, Daisuke Kobayashi, Chie Tanaka, Suguru Yamada, Masahiko Koike, Michitaka Fujiwara, Masato Nagino, Yasuhiro Kodera

    International journal of clinical oncology   Vol. 25 ( 1 ) page: 118 - 125   2020.1

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    OBJECTIVE: This multicenter, single-arm phase II study (UMIN000008429) aimed to evaluate the efficacy and safety of capecitabine plus oxaliplatin (CapOX) as postoperative adjuvant chemotherapy for patients with locally advanced rectal cancer. METHODS: Patients with resectable clinical Stage II or III rectal cancer were enrolled to receive eight cycles of CapOX therapy (130 mg/m2 oxaliplatin on day 1 and 2000 mg/m2 oral capecitabine on days 1-14, every 3 weeks) after curative surgical resection. The primary endpoint was 3-year relapse-free survival (RFS) rate, and secondary endpoints were 3-year overall survival (OS) rate, treatment compliance, and safety. RESULTS: A total of 40 patients (Stage II, 21; Stage III, 19) were enrolled between September 2012 and November 2015 from seven institutions. Thirty-nine patients (97%) received R0 resection, and 32 patients (84%) received postoperative CapOX therapy. The completion rate of all eight cycles of CapOX therapy was 66%. Relative dose intensities were 87% for oxaliplatin and 84% for capecitabine. At a median follow-up period of 46 months, disease recurrence was observed in nine patients, including three with local recurrence. Three-year RFS and OS rates were 75% (95% CI 57-86%) and 96% (95% CI 80-99%), respectively. Frequencies of Grade ≥ 3 hematological and non-hematologic adverse events were 19% and 38%, respectively. CONCLUSION: CapOX therapy is feasible as adjuvant chemotherapy for locally advanced rectal cancer.

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  157. Tumor size  ≥50 mm as an Independent Prognostic Factor for Patients with Stage II or III Gastric Cancer After Postoperative S-1 Monotherapy: Analysis of a Multi-institution Dataset. Reviewed International journal

    Masayuki Tsutsuyama, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

    World journal of surgery   Vol. 44 ( 1 ) page: 194 - 201   2020.1

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    BACKGROUND: Little is known about the changes in prognostic factors after adjuvant S-1 monotherapy has become widespread as a standard of care for patients with gastric cancer (GC) in East Asia. The present study compared prognostic factors of patients with stage II/III GC treated with or without S-1 adjuvant to formulate appropriate risk stratification strategies. METHODS: We designed a large multicenter dataset and retrospectively analyzed 847 patients with GC stage II or III, who underwent curative gastrectomy between 2010 and 2014. Clinicopathological features and prognostic factors were compared between the two patient groups: surgery-alone (n = 266) and S-1 adjuvant (n = 581). RESULTS: There were no significant differences in pathological tumor depths, nodal status, and disease stages between groups. Recurrence-free survival was significantly longer in the S-1 adjuvant group. For the surgery-alone group, independent prognostic factors were (in order of hazard ratio): (1) invasive growth, (2) high preoperative carcinoembryonic antigen levels, (3) total gastrectomy. For the S-1 adjuvant group, macroscopic tumor size (≥50 mm) was identified as another independent prognostic factor next only to pN2/3. There was overlap between the survival curves of patients with tumor size  ≥50 mm in both groups. After receiving adjuvant S-1 monotherapy,  ≥50 mm patients had significantly higher prevalence of peritoneal and lymph node metastasis as initial recurrences compared with  <50 mm patients. CONCLUSIONS: Adjuvant S-1 monotherapy may alter listing of adverse prognostic factors of stage II and III patients. Macroscopic tumor size  ≥50 mm may serve as an important determinant for risk stratification to identify patients who require more intensive treatment.

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  158. 食道亜全摘術後の肺炎発生予測因子の検討 Reviewed

    神田 光郎, 小池 聖彦, 清水 大, 田中 千恵, 小林 大介, 園原 史訓, 猪川 祥邦, 高見 秀樹, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 藤原 道隆, 小寺 泰弘

    日本消化管学会雑誌   Vol. 4 ( Suppl. ) page: 303 - 303   2020.1

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  159. Characteristics of Lung Metastasis as an Initial Recurrence Pattern After Curative Resection of Pancreatic Cancer Reviewed

    Morimoto Daishi, Yamada Suguru, Sonohara Fuminori, Takami Hideki, Hayashi Masamichi, Kanda Mitsuro, Tanaka Chie, Kobayashi Daisuke, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Fujii Tsutomu, Kodera Yasuhiro

    PANCREAS   Vol. 49 ( 5 ) page: 699 - 705   2020

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    DOI: 10.1097/MPA.0000000000001559

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  160. Chromobox 2 Expression Predicts Prognosis After Curative Resection of Oesophageal Squamous Cell Carcinoma Reviewed

    Ueda Sei, Kanda Mitsuro, Sato Yusuke, Baba Hayato, Nakamura Shunsuke, Sawaki Koichi, Shimizu Dai, Motoyama Satoru, Fujii Tsutomu, Kodera Yasuhiro, Nomoto Shuji

    CANCER GENOMICS & PROTEOMICS   Vol. 17 ( 4 ) page: 391 - 400   2020

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    DOI: 10.21873/cgp.20198

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  161. STRA6 Expression Serves as a Prognostic Biomarker of Gastric Cancer Reviewed

    Nakamura Shunsuke, Kanda Mitsuro, Shimizu Dai, Sawaki Kouichi, Tanaka Chie, Hattori Norifumi, Hayashi Masamichi, Yamada Suguru, Nakayama Goro, Omae Kenji, Koike Masahiko, Kodera Yasuhiro

    CANCER GENOMICS & PROTEOMICS   Vol. 17 ( 5 ) page: 509 - 516   2020

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    DOI: 10.21873/cgp.20207

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  162. The Preoperative Prognostic Nutritional Index Predicts Short-Term and Long-Term Outcomes of Patients with Stage II/III Gastric Cancer: Analysis of a Multi-Institution Dataset.

    Sasahara M, Kanda M, Ito S, Mochizuki Y, Teramoto H, Ishigure K, Murai T, Asada T, Ishiyama A, Matsushita H, Tanaka C, Kobayashi D, Fujiwara M, Murotani K, Kodera Y

    Digestive surgery   Vol. 37 ( 2 ) page: 135 - 144   2020

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    DOI: 10.1159/000497454

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  163. ASO Author Reflections: Homeobox C10 Influences on the Malignant Phenotype of Gastric Cancer Cell Lines and its Elevated Expression Positively Correlates with Recurrence and Poor Survival Reviewed

    Miwa Takashi, Kanda Mitsuro

    ANNALS OF SURGICAL ONCOLOGY   Vol. 26 ( Suppl 3 ) page: S596 - S597   2019.12

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    DOI: 10.1245/s10434-019-07405-9

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  164. ASO Author Reflections: Increased Expression of DNAJC12 is Associated with Aggressive Phenotype of Gastric Cancer Reviewed

    Uno Yasuo, Kanda Mitsuro

    ANNALS OF SURGICAL ONCOLOGY   Vol. 26 ( Suppl 3 ) page: S592 - S593   2019.12

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    DOI: 10.1245/s10434-019-07404-w

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  165. Modified Systemic Inflammation Score is Useful for Risk Stratification After Radical Resection of Squamous Cell Carcinoma of the Esophagus. Reviewed

    Kanda M, Koike M, Tanaka C, Kobayashi D, Hattori N, Hayashi M, Yamada S, Omae K, Fujiwara M, Kodera Y

    Annals of surgical oncology   Vol. 26 ( 13 ) page: 4773 - 4781   2019.12

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    DOI: 10.1245/s10434-019-07914-7

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  166. ミラーイメージはカメラを180度回転させると操作が容易になる Reviewed

    砂川 祐輝, 山田 豪, 園原 史訓, 猪川 祥邦, 高見 秀樹, 林 真路, 神田 光郎, 田中 千恵, 小林 大介, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本内視鏡外科学会雑誌   Vol. 24 ( 7 ) page: SF029 - 4   2019.12

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  167. 腹腔鏡下手術による膵体尾部切除術後の門脈・脾静脈血栓症に対する影響 Reviewed

    山田 豪, 園原 史訓, 高見 秀樹, 猪川 祥邦, 林 真路, 神田 光郎, 小林 大介, 田中 千恵, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本内視鏡外科学会雑誌   Vol. 24 ( 7 ) page: MO180 - 5   2019.12

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  168. 食道癌FP療法によるRenal Salt-Wasting Syndromeの2例 Reviewed

    梅田 晋一, 神田 光郎, 小池 聖彦, 清水 大, 田中 千恵, 小林 大介, 園原 史訓, 高見 秀樹, 猪川 祥邦, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 藤原 道隆, 小寺 泰弘

    日本臨床外科学会雑誌   Vol. 80 ( 12 ) page: 2312 - 2312   2019.12

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  169. Comparison of non-invasive liver reserve and fibrosis models: implications for surgery and prognosis for hepatocellular carcinoma. Reviewed

    Sonohara F, Yamada S, Tanaka N, Tashiro M, Sunagawa Y, Morimoto D, Tanaka H, Takami H, Hayashi M, Kanda M, Tanaka C, Kobayashi D, Nakayama G, Koike M, Fujiwara M, Kodera Y

    Hepatology research : the official journal of the Japan Society of Hepatology   Vol. 49 ( 11 ) page: 1305 - 1315   2019.11

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    DOI: 10.1111/hepr.13400

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  170. The levels of SYT13 and CEA mRNAs in peritoneal lavages predict the peritoneal recurrence of gastric cancer. Reviewed

    Nakanishi K, Kanda M, Umeda S, Tanaka C, Kobayashi D, Hayashi M, Yamada S, Kodera Y

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   Vol. 22 ( 6 ) page: 1143 - 1152   2019.11

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    DOI: 10.1007/s10120-019-00967-3

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  171. PRAME Expression as a Potential Biomarker for Hematogenous Recurrence of Esophageal Squamous Cell Carcinoma Reviewed

    Baba Hayato, Kanda Mitsuro, Sawaki Koichi, Shimizu Dai, Umeda Shinichi, Koike Masahiko, Kodera Yasuhiro, Fujii Tsutomu

    ANTICANCER RESEARCH   Vol. 39 ( 11 ) page: 5943 - 5951   2019.11

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    DOI: 10.21873/anticanres.13799

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  172. Expression, Function, and Prognostic Value of MAGE-D4 Protein in Esophageal Squamous Cell Carcinoma. Reviewed

    Uno Y, Kanda M, Sato Y, Shimizu D, Umeda S, Hattori N, Hayashi M, Tanaka C, Kobayashi D, Yamada S, Nakayama G, Motoyama S, Koike M, Kodera Y

    Anticancer research   Vol. 39 ( 11 ) page: 6015 - 6023   2019.11

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    DOI: 10.21873/anticanres.13807

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  173. Delay in initiation of postoperative adjuvant chemotherapy with S-1 monotherapy and prognosis for gastric cancer patients: analysis of a multi-institutional dataset. Reviewed

    Nakanishi K, Kanda M, Ito S, Mochizuki Y, Teramoto H, Ishigure K, Murai T, Asada T, Ishiyama A, Matsushita H, Tanaka C, Kobayashi D, Fujiwara M, Murotani K, Kodera Y

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   Vol. 22 ( 6 ) page: 1215 - 1225   2019.11

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    DOI: 10.1007/s10120-019-00961-9

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  174. Level of Melanotransferrin in Tissue and Sera Serves as a Prognostic Marker of Gastric Cancer. Reviewed

    Sawaki K, Kanda M, Umeda S, Miwa T, Tanaka C, Kobayashi D, Hayashi M, Yamada S, Nakayama G, Omae K, Koike M, Kodera Y

    Anticancer research   Vol. 39 ( 11 ) page: 6125 - 6133   2019.11

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    DOI: 10.21873/anticanres.13820

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  175. Tissue Expression of Melanoma-associated Antigen A6 and Clinical Characteristics of Gastric Cancer. Reviewed

    Endo M, Kanda M, Sawaki K, Shimizu D, Tanaka C, Kobayashi D, Hattori N, Hayashi M, Yamada S, Koike M, Omae K, Kodera Y

    Anticancer research   Vol. 39 ( 11 ) page: 5903 - 5910   2019.11

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    DOI: 10.21873/anticanres.13794

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  176. 妊娠を契機に急速増大を来したMCNと術前診断した膵リンパ管腫の一切除例 Reviewed

    加藤 吉康, 山田 豪, 高見 秀樹, 園原 史訓, 猪川 祥邦, 林 真路, 服部 憲史, 神田 光郎, 小林 大介, 田中 千恵, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本消化器病学会東海支部例会プログラム抄録集   Vol. 131回   page: 75 - 75   2019.11

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  177. 胃原発mixed adenoneuroendocrine carcinomaの1例 Reviewed

    荘加 道太, 清水 大, 栗本 景介, 園原 史訓, 猪川 祥邦, 高見 秀樹, 服部 憲史, 林 真路, 神田 光郎, 田中 千恵, 小林 大介, 山田 豪, 中山 吾郎, 小池 聖彦, 小寺 泰弘

    日本消化器病学会東海支部例会プログラム抄録集   Vol. 131回   page: 59 - 59   2019.11

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  178. Feasibility of subtotal esophagectomy with systematic lymphadenectomy in selected elderly patients with esophageal cancer; a propensity score matching analysis. Reviewed

    Kanda M, Koike M, Tanaka C, Kobayashi D, Hayashi M, Yamada S, Nakayama G, Omae K, Kodera Y

    BMC surgery   Vol. 19 ( 1 ) page: 143   2019.10

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    DOI: 10.1186/s12893-019-0617-2

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  179. Novel implications of combined arterial resection for locally advanced pancreatic cancer in the era of newer chemo-regimens. Reviewed

    Sonohara F, Yamada S, Takami H, Hayashi M, Kanda M, Tanaka C, Kobayashi D, Nakayama G, Koike M, Fujiwara M, Fujii T, Kodera Y

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology   Vol. 45 ( 10 ) page: 1895 - 1900   2019.10

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    DOI: 10.1016/j.ejso.2019.05.019

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  180. Risk Prediction of Postoperative Pneumonia After Subtotal Esophagectomy Based on Preoperative Serum Cholinesterase Concentrations. Reviewed

    Kanda M, Koike M, Tanaka C, Kobayashi D, Hayashi M, Yamada S, Omae K, Kodera Y

    Annals of surgical oncology   Vol. 26 ( 11 ) page: 3718 - 3726   2019.10

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    DOI: 10.1245/s10434-019-07512-7

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  181. Conversion Surgery施行例の予後因子から検討した切除不能胃癌に対する集学的治療戦略 Reviewed

    小林 大介, 神田 光郎, 田中 千恵, 清水 大, 園原 史訓, 猪川 祥邦, 高見 秀樹, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本癌治療学会学術集会抄録集   Vol. 57回   page: RT21 - 5   2019.10

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  182. 日本のAYA世代のがん対策の方向性を読み解く Reviewed

    栗本 景介, 堀部 敬三, 園原 史訓, 猪川 祥邦, 高見 秀樹, 林 真路, 神田 光郎, 小林 大介, 田中 千恵, 山田 豪, 中山 吾郎, 小池 聖彦, 清水 千佳子, 高橋 義行, 小寺 泰弘

    日本癌治療学会学術集会抄録集   Vol. 57回   page: P166 - 5   2019.10

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  183. 切除不能進行再発胃癌に対するnivolumab療法における好中球/リンパ球比の臨床的意義 Reviewed

    小林 大介, 清水 大, 神田 光郎, 田中 千恵, 園原 史訓, 猪川 祥邦, 高見 秀樹, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本臨床外科学会雑誌   Vol. 80 ( 増刊 ) page: 506 - 506   2019.10

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  184. トランスレーショナルリサーチについて考える:臨床現場のアイデアをどう生かすか 消化器外科医ならではの創薬シーズを求めて Reviewed

    神田 光郎, 清水 大, 田中 千恵, 小林 大介, 園原 史訓, 猪川 祥邦, 高見 秀樹, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本臨床外科学会雑誌   Vol. 80 ( 増刊 ) page: 360 - 360   2019.10

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  185. DNAJC12の胃癌における役割についての検討 Reviewed

    宇野 泰朗, 神田 光郎, 清水 大, 田中 千恵, 小林 大介, 園原 史訓, 服部 憲史, 高見 秀樹, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本癌治療学会学術集会抄録集   Vol. 57回   page: O7 - 4   2019.10

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  186. 胃癌におけるETNK2のアポトーシスへの関与と肝転移形成の関連性 Reviewed

    三輪 高嗣, 神田 光郎, 田中 千恵, 小林 大介, 園原 史訓, 高見 秀樹, 清水 大, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本癌治療学会学術集会抄録集   Vol. 57回   page: O8 - 3   2019.10

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  187. 開腹・開胸手術のメリット・デメリットについて考える 開胸アプローチを活用する食道癌治療戦略 開胸のメリットは再建にあり? Reviewed

    小池 聖彦, 佐藤 雄介, 園原 史訓, 清水 大, 高見 秀樹, 猪川 祥邦, 服部 憲史, 林 真路, 神田 光郎, 小林 大介, 田中 千恵, 山田 豪, 中山 吾郎, 藤原 道隆, 小寺 泰弘

    日本臨床外科学会雑誌   Vol. 80 ( 増刊 ) page: 351 - 351   2019.10

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  188. 長期予後が得られた症例1(上部消化管) HER2陽性切除不能進行胃癌に対するtrastuzumab療法とconversion surgeryによる集学的治療 Reviewed

    佐藤 敏, 小林 大介, 清水 大, 神田 光郎, 田中 千恵, 園原 史訓, 猪川 祥邦, 高見 秀樹, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本臨床外科学会雑誌   Vol. 80 ( 増刊 ) page: 404 - 404   2019.10

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  189. 英文論文について考える:方法論・重要性を中心に 臨床外科医が英文論文を書く際の最初のハードルを越える 定型化と剽窃回避 Reviewed

    神田 光郎, 清水 大, 田中 千恵, 小林 大介, 園原 史訓, 猪川 祥邦, 高見 秀樹, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本臨床外科学会雑誌   Vol. 80 ( 増刊 ) page: 346 - 346   2019.10

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  190. 腹腔鏡下胃切除術におけるIndocyanine Green蛍光法を用いた病変位置同定方法 Reviewed

    田中 千恵, 神田 光郎, 林 真路, 服部 憲史, 小林 大介, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本臨床外科学会雑誌   Vol. 80 ( 増刊 ) page: 472 - 472   2019.10

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  191. 胃癌根治切除術後S-1補助化学療法の忍容性予測因子の検討 Reviewed

    三輪 高嗣, 神田 光郎, 田中 千恵, 小林 大介, 園原 史訓, 高見 秀樹, 服部 憲史, 猪川 祥邦, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本臨床外科学会雑誌   Vol. 80 ( 増刊 ) page: 570 - 570   2019.10

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  192. 胃癌のおけるS-1術後補助化学療法開始時期と予後との関係 多施設統合データベース Reviewed

    中西 香企, 神田 光郎, 伊藤 誠二, 望月 能成, 寺本 仁, 石榑 清, 村井 俊文, 浅田 崇洋, 石山 聡治, 松下 英信, 田中 千恵, 小林 大介, 藤原 道隆, 小寺 泰弘

    日本癌治療学会学術集会抄録集   Vol. 57回   page: O56 - 1   2019.10

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  193. Incorporating molecular biomarkers into clinical practice for gastric cancer Reviewed

    Nakamura Shunsuke, Kanda Mitsuro, Kodera Yasuhiro

    EXPERT REVIEW OF ANTICANCER THERAPY   Vol. 19 ( 9 ) page: 757 - 771   2019.9

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    DOI: 10.1080/14737140.2019.1659136

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  194. Biological and conditional factors should be included when defining criteria for resectability for patients with pancreatic cancer.

    Kato Y, Yamada S, Tashiro M, Sonohara F, Takami H, Hayashi M, Kanda M, Kobayashi D, Tanaka C, Nakayama G, Koike M, Fujiwara M, Kodera Y

    HPB : the official journal of the International Hepato Pancreato Biliary Association   Vol. 21 ( 9 ) page: 1211 - 1218   2019.9

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    DOI: 10.1016/j.hpb.2019.01.012

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  195. Multi-institutional analysis of the prognostic significance of postoperative complications after curative resection for gastric cancer. Reviewed International journal

    Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

    Cancer medicine   Vol. 8 ( 11 ) page: 5194 - 5201   2019.9

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    BACKGROUND: Insufficient data are available on the prognostic significance of complications after resection of gastric cancer. Therefore, we aimed to assess this gap in our knowledge by studying patients with resectable gastric cancer. METHODS: A multi-institutional retrospective database comprising clinical information of 3575 patients who received resection of gastric cancer from 2010 to 2014 at nine institutions. Grades 2 or greater complications of the Clavien-Dindo classification were judged as clinically relevant postoperative complications, and their associations with postoperative survival were assessed. We assessed the effect of complications on times of initiation and continuation of postoperative adjuvant chemotherapy by S-1. RESULTS: A total of 2954 patients were included in the analysis. Clinically relevant postoperative complications occurred in 664 (23%) patients. Patients' recurrence-free survival rate incrementally decreased as the grade of complications became greater. Patients with abdominal complications (eg, leakage of pancreatic fluids, intra-abdominal abscess, and anastomotic leakage) and those with nonabdominal complications (eg, pneumonia) experienced worse recurrence-free survival compared to those without complications. Patients who had complications were generally at greater risk of disease recurrence, except for those who underwent laparoscopic surgery and those with pathological stage I. Delayed initiation and shorter continuation of adjuvant S-1 chemotherapy was experienced by patients with postoperative complications. CONCLUSIONS: Postoperative complications adversely affected the prognosis in patients with resectable gastric cancer.

    DOI: 10.1002/cam4.2439

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  196. Recent advances in molecular biomarkers for patients with hepatocellular carcinoma Reviewed

    Umeda Shinichi, Kanda Mitsuro, Kodera Yasuhiro

    EXPERT REVIEW OF MOLECULAR DIAGNOSTICS   Vol. 19 ( 8 ) page: 725 - 738   2019.8

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    DOI: 10.1080/14737159.2019.1638254

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  197. Proposal of a Scoring Scale to Estimate Risk of the Discontinuation of S-1 Adjuvant Monotherapy in Patients with Stage II to III Gastric Cancer: A Multi-Institutional Dataset Analysis.

    Iizuka A, Kanda M, Ito S, Mochizuki Y, Teramoto H, Ishigure K, Murai T, Asada T, Ishiyama A, Matsushita H, Tanaka C, Kobayashi D, Fujiwara M, Murotani K, Kodera Y

    World journal of surgery   Vol. 43 ( 8 ) page: 2016 - 2024   2019.8

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    DOI: 10.1007/s00268-019-04942-y

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  198. Number of retrieved lymph nodes is an independent prognostic factor after total gastrectomy for patients with stage III gastric cancer: propensity score matching analysis of a multi-institution dataset.

    Hayashi S, Kanda M, Ito S, Mochizuki Y, Teramoto H, Ishigure K, Murai T, Asada T, Ishiyama A, Matsushita H, Tanaka C, Kobayashi D, Fujiwara M, Murotani K, Kodera Y

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   Vol. 22 ( 4 ) page: 853 - 863   2019.7

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    DOI: 10.1007/s10120-018-0902-2

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  199. Functions of FRAS1 as a driver gene of liver metastasis from gastric cancer analyzed by the genome editing technology Reviewed

    Umeda Shinichi, Kanda Mitsuro, Tanaka Haruyoshi, Sonohara Fuminori, Takami Hideki, Hattori Norifumi, Hayashi Masamichi, Tanaka Chie, Kobayashi Daisuke, Yamada Suguru, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    CANCER RESEARCH   Vol. 79 ( 13 )   2019.7

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    DOI: 10.1158/1538-7445.AM2019-863

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  200. Genomewide expression profiling identifies a novel miRNA-based signature for the detection of peritoneal metastasis in gastric cancer Reviewed

    Shimura Tadanobu, Toden Shusuke, Kandimalla Raju, Toiyama Yuji, Okugawa Yoshinaga, Kanda Mitsuro, Baba Hideo, Kodera Yasuhiro, Kusunoki Masato, Hori Hiroki, Goel Ajay

    CANCER RESEARCH   Vol. 79 ( 13 )   2019.7

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  201. 切除不能胃癌に対するConversion Surgeryの適応と予後因子の検討 Reviewed

    小林 大介, 神田 光郎, 田中 千恵, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本消化器外科学会総会   Vol. 74回   page: P33 - 1   2019.7

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  202. 胃癌に対するS-1術後補助化学療法の開始時期と予後に関する検討 Reviewed

    中西 香企, 神田 光郎, 伊藤 誠二, 望月 能成, 寺本 仁, 石榑 清, 村井 俊文, 浅田 崇洋, 石山 聡治, 小寺 泰弘

    日本消化器外科学会総会   Vol. 74回   page: P75 - 3   2019.7

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  203. Long-lasting discussion: Adverse effects of intraoperative blood loss and allogeneic transfusion on prognosis of patients with gastric cancer. Reviewed

    Nakanishi K, Kanda M, Kodera Y

    World journal of gastroenterology   Vol. 25 ( 22 ) page: 2743 - 2751   2019.6

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  204. Albumin-Bilirubin Score Predicts Tolerability to Adjuvant S-1 Monotherapy after Curative Gastrectomy. Reviewed

    Miwa T, Kanda M, Tanaka C, Kobayashi D, Hayashi M, Yamada S, Nakayama G, Koike M, Kodera Y

    Journal of gastric cancer   Vol. 19 ( 2 ) page: 183 - 192   2019.6

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  205. Genome-wide Discovery of a Novel Gene-expression Signature for the Identification of Lymph Node Metastasis in Esophageal Squamous Cell Carcinoma. Reviewed International journal

    Fuminori Sonohara, Feng Gao, Naoki Iwata, Mitsuro Kanda, Masahiko Koike, Naoki Takahashi, Yasuhide Yamada, Yasuhiro Kodera, Xin Wang, Ajay Goel

    Annals of surgery   Vol. 269 ( 5 ) page: 879 - 886   2019.5

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    OBJECTIVE: This study aimed to develop a gene-expression signature for identification of lymph node (LN) metastasis in esophageal squamous cell carcinoma (ESCC) patients. SUMMARY OF BACKGROUND DATA: LN metastasis is recognized as the most important independent risk factor for therapeutic decision-making of ESCC patients. METHODS: A bioinformatic approach was used to analyze RNA sequencing profiles of ESCC patients, and to develop a gene-expression signature for identifying LN metastasis. The robustness of this panel was assessed in 2 independent patient cohorts (n = 56 and 224). RESULTS: We initially prioritized a 16-gene signature out of the total 20,531 mRNAs. The model estimated by these 16 genes discriminated LN status with an area under the curve (AUC) of 0.77 [95% confidence interval (95% CI), 0.68-0.87, 5-fold cross-validation]. Subsequently, a reduced and optimized 5-gene panel was trained in a clinical cohort, which effectively distinguished ESCC patients with LN metastasis (cohort-1: AUC, 0.74; 95% CI, 0.58-0.89; cohort-2, T1-T2: AUC, 0.74; 95% CI, 0.63-0.86), and was significantly superior to preoperative computed tomography (AUC, 0.61; 95% CI, 0.50-0.72). Furthermore, a combination signature comprising of the 5-gene panel together with the lymphatic vessel invasion (LVI) and venous invasion (VI) demonstrated a significantly improved diagnostic performance compared with individual clinical variables, in both cohorts (cohort-1: AUC, 0.87; 95% CI, 0.78-0.96; cohort-2: AUC, 0.76; 95% CI, 0.65-0.88). CONCLUSION: Our novel 5-gene panel is a robust diagnostic tool for LN metastasis, especially in early-T stage ESCC patients, with a promising clinical potential.

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  206. Homeobox C10 Influences on the Malignant Phenotype of Gastric Cancer Cell Lines and its Elevated Expression Positively Correlates with Recurrence and Poor Survival.

    Miwa T, Kanda M, Umeda S, Tanaka H, Tanaka C, Kobayashi D, Suenaga M, Hayashi M, Yamada S, Nakayama G, Koike M, Kodera Y

    Annals of surgical oncology   Vol. 26 ( 5 ) page: 1535 - 1543   2019.5

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  207. Long-term quality of life and nutrition status of the aboral pouch reconstruction after total gastrectomy for gastric cancer: a prospective multicenter observational study (CCOG1505).

    Tanaka C, Kanda M, Murotani K, Yoshikawa T, Cho H, Ito Y, Matsui T, Nakayama H, Yamada T, Kobayashi D, Fujiwara M, Kodera Y

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   Vol. 22 ( 3 ) page: 607 - 616   2019.5

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  208. Increased Expression of DNAJC12 is Associated with Aggressive Phenotype of Gastric Cancer.

    Uno Y, Kanda M, Miwa T, Umeda S, Tanaka H, Tanaka C, Kobayashi D, Suenaga M, Hattori N, Hayashi M, Yamada S, Nakayama G, Fujiwara M, Kodera Y

    Annals of surgical oncology   Vol. 26 ( 3 ) page: 836 - 844   2019.3

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  209. Intraoperative Blood Loss is Associated with Shortened Postoperative Survival of Patients with Stage II/III Gastric Cancer: Analysis of a Multi-institutional Dataset.

    Ito Y, Kanda M, Ito S, Mochizuki Y, Teramoto H, Ishigure K, Murai T, Asada T, Ishiyama A, Matsushita H, Tanaka C, Kobayashi D, Fujiwara M, Murotani K, Kodera Y

    World journal of surgery   Vol. 43 ( 3 ) page: 870 - 877   2019.3

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    DOI: 10.1007/s00268-018-4834-0

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  210. A genomewide transcriptomic approach identifies a novel gene expression signature for the detection of lymph node metastasis in patients with early stage gastric cancer Reviewed International journal

    D. Izumi, F. Gao, S. Toden, F. Sonohara, M. Kanda, T. Ishimoto, Y. Kodera, X. Wang, H. Baba, A. Goel

    EBioMedicine   Vol. 41   page: 268 - 275   2019.3

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    BACKGROUND: Although identification of lymph node (LN) metastasis is a well-recognized strategy for improving outcomes in patients with gastric cancer (GC), currently there is lack of availability of adequate molecular biomarkers that can identify such metastasis. Herein we have developed a robust gene-expression signature for detecting LN metastasis in early stage GC by using a transcriptome-wide biomarker discovery and subsequent validation in multiple clinical cohorts. METHODS: A total of 532 patients with pathological T1 and T2 GC from 4 different cohorts were analyzed. Two independent datasets (n = 96, and n = 188) were used to establish a gene signature for the identification of LN metastasis in GC patients. The diagnostic performance of our gene-expression signature was subsequently assessed in two independent clinical cohorts using qRT-PCR assays (n = 101, and n = 147), and subsequently compared against conventional tumor markers and image-based diagnostics. FINDINGS: We established a 15-gene signature by analyzing multiple high throughput datasets, which robustly distinguished LN status in both training (AUC = 0.765, 95% CI 0.667-0.863) and validation cohorts (AUC = 0.742, 95% CI 0.630-0.852). Notably, the 15-gene signature was significantly superior compared to the conventional tumor markers, CEA (P = .04) and CA19-9 (P = .005), as well as computed tomography-based imaging (P = .04). INTERPRETATION: We have established and validated a 15-gene signature for detecting LN metastasis in GC patients, which offers a robust diagnostic tool for potentially improving treatment outcomes in gastric cancer patients. FUND: NIH: CA72851, CA181572, CA14792, CA202797, CA187956; CPRIT: RP140784: Baylor Sammons Cancer Center polot grants (AG), VPRT: 9610337, CityU 21101115, 11102317, 11103718; JCYJ20170307091256048 (XW).

    DOI: 10.1016/j.ebiom.2019.01.057

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  211. Prediction of peritoneal recurrences of gastric cancer by qPCR analysis of peritoneal lavage fluids. Reviewed

    Nakanishi Koki, Kanda Mitsuro, Umeda Shinichi, Tanaka Chie, Kobayashi Daisuke, Hayashi Masamichi, Yamada Suguru, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 37 ( 4 )   2019.2

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  212. The Controlling Nutritional Status Score Serves as a Predictor of Short- and Long-Term Outcomes for Patients with Stage 2 or 3 Gastric Cancer: Analysis of a Multi-institutional Data Set.

    Ryo S, Kanda M, Ito S, Mochizuki Y, Teramoto H, Ishigure K, Murai T, Asada T, Ishiyama A, Matsushita H, Tanaka C, Kobayashi D, Fujiwara M, Murotani K, Kodera Y

    Annals of surgical oncology   Vol. 26 ( 2 ) page: 456 - 464   2019.2

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  213. 胃癌におけるMelanotransferrin発現と臨床的意義の検討 Reviewed

    澤木 康一, 神田 光郎, 田中 千恵, 小林 大介, 園原 史訓, 服部 憲史, 末永 雅也, 高見 秀樹, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本胃癌学会総会記事   Vol. 91回   page: 490 - 490   2019.2

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  214. Prognostic significance of perioperative tumor marker levels in stage II/III gastric cancer.

    Suenaga Y, Kanda M, Ito S, Mochizuki Y, Teramoto H, Ishigure K, Murai T, Asada T, Ishiyama A, Matsushita H, Tanaka C, Kobayashi D, Fujiwara M, Murotani K, Kodera Y

    World journal of gastrointestinal oncology   Vol. 11 ( 1 ) page: 17 - 27   2019.1

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  215. Identification of a serum-based miRNA signature for response of esophageal squamous cell carcinoma to neoadjuvant chemotherapy

    Niwa Yukiko, Yamada Suguru, Sonohara Fuminori, Kurimoto Keisuke, Hayashi Masamichi, Tashiro Mitsuru, Iwata Naoki, Kanda Mitsuro, Tanaka Chie, Kobayashi Daisuke, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    JOURNAL OF TRANSLATIONAL MEDICINE   Vol. 17 ( 1 ) page: 1   2019.1

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    DOI: 10.1186/s12967-018-1762-6

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  216. Optical trocar access for initial trocar placement in laparoscopic gastrointestinal surgery: A propensity score-matching analysis. Reviewed

    Tanaka C, Fujiwara M, Kanda M, Murotani K, Iwata N, Hayashi M, Kobayashi D, Yamada S, Kodera Y

    Asian journal of endoscopic surgery   Vol. 12 ( 1 ) page: 37 - 42   2019.1

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    DOI: 10.1111/ases.12484

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  217. Perioperative and prognostic implication of albumin-bilirubin-TNM score in Child-Pugh class A hepatocellular carcinoma.

    Sonohara F, Yamada S, Tanaka N, Suenaga M, Takami H, Hayashi M, Niwa Y, Sugimoto H, Hattori N, Kanda M, Tanaka C, Kobayashi D, Nakayama G, Koike M, Fujiwara M, Kodera Y

    Annals of gastroenterological surgery   Vol. 3 ( 1 ) page: 65 - 74   2019.1

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  218. Establishment of Peritoneal and Hepatic Metastasis Mouse Xenograft Models Using Gastric Cancer Cell Lines. Reviewed

    Miwa T, Kanda M, Umeda S, Tanaka H, Shimizu D, Tanaka C, Kobayashi D, Hayashi M, Yamada S, Nakayama G, Koike M, Kodera Y

    In vivo (Athens, Greece)   Vol. 33 ( 6 ) page: 1785 - 1792   2019

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    DOI: 10.21873/invivo.11669

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  219. Peritoneal Lavage Tumor DNA as a Novel Biomarker for Predicting Peritoneal Recurrence in Pancreatic Ductal Adenocarcinoma Reviewed

    Suenaga M., Fujii T., Yamada S., Hayashi M., Shinjo K., Takami H., Niwa Y., Sonohara F., Shimizu D., Kanda M., Kobayashi D., Tanaka C., Nakayama G., Koike M., Fujiwara M., Kondo Y., Kodera Y.

    PANCREAS   Vol. 48 ( 10 ) page: 1528 - 1528   2019

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  220. ASO Author Reflections: Troponin I2-A Specific Biomarker for Detection and Prediction of Peritoneal Metastasis in Gastric Cancer. Reviewed

    Sawaki K, Kanda M

    Annals of surgical oncology   Vol. 25 ( Suppl 3 ) page: 709 - 710   2018.12

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  221. A New Biomarker for Peritoneal Lavage Using Digital PCR in Patients with Pancreatic Ductal Adenocarcinoma Reviewed

    Suenaga Masaya, Yamada Suguru, Hayashi Masamichi, Kanda Mitsuro, Tanaka Chie, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    CANCER SCIENCE   Vol. 109   page: 650-650   2018.12

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  222. RASEF expression correlates with hormone receptor status in breast cancer

    Shibata Masahiro, Kanda Mitsuro, Shimizu Dai, Tanaka Haruyoshi, Umeda Shinichi, Miwa Takashi, Hayashi Masamichi, Inaishi Takahiro, Miyajima Noriyuki, Adachi Yayoi, Takano Yuko, Nakanishi Kenichi, Takeuchi Dai, Noda Sumiyo, Kodera Yasuhiro, Kikumori Toyone

    ONCOLOGY LETTERS   Vol. 16 ( 6 ) page: 7223 - 7230   2018.12

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    DOI: 10.3892/ol.2018.9542

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  223. Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi-institutional dataset.

    Nakagawa N, Kanda M, Ito S, Mochizuki Y, Teramoto H, Ishigure K, Murai T, Asada T, Ishiyama A, Matsushita H, Tanaka C, Kobayashi D, Fujiwara M, Murotani K, Kodera Y

    Cancer medicine   Vol. 7 ( 12 ) page: 6020 - 6029   2018.12

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    DOI: 10.1002/cam4.1868

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  224. Homeobox C10 correlates with the malignant phenotype of gastric cancer and its recurrence and poor survival Reviewed

    Miwa Takashi, Kanda Mitsuro, Tanaka Chie, Yamada Suguru, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    CANCER SCIENCE   Vol. 109   page: 1127-1127   2018.12

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  225. FRAS1 expression reflects the malignancy potential of gastric cancer Reviewed

    Umeda Shinichi, Kanda Mitsuro, Tanaka Chie, Yamada Suguru, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    CANCER SCIENCE   Vol. 109   page: 1128-1128   2018.12

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  226. Copine 5 expression predicts prognosis following curative resection of esophageal squamous cell carcinoma

    Umeda Shinichi, Kanda Mitsuro, Koike Masahiko, Tanaka Haruyoshi, Miwa Takashi, Tanaka Chie, Kobayashi Daisuke, Suenaga Masaya, Hayashi Masamichi, Yamada Suguru, Nakayama Goro, Kodera Yasuhiro

    ONCOLOGY REPORTS   Vol. 40 ( 6 ) page: 3772 - 3780   2018.12

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    DOI: 10.3892/or.2018.6742

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  227. Biological significance of ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 (AGAP3) in colorectal cancer (CRC) Reviewed

    Shimizu Dai, Sato Kuniaki, Masuda Takaaki, Otsu Hajime, Kuroda Yousuke, Eguchi Hidetoshi, Kanda Mitsuro, Kodera Yasuhiro, Mimori Koshi

    CANCER SCIENCE   Vol. 109   page: 1235-1235   2018.12

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  228. Integrated multigene expression panel to prognosticate patients with gastric cancer Reviewed

    Kanda Mitsuro, Miwa Takashi, Umeda Shinichi, Tanaka Chie, Hayashi Masamichi, Suenaga Masaya, Yamada Suguru, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    CANCER SCIENCE   Vol. 109   page: 769 - 769   2018.12

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  229. Troponin I2 as a specific biomarker for prediction of peritoneal metastasis in gastric cancer Reviewed

    Sawaki Koichi, Kanda Mitsuro, Suenaga Masaya, Hayashi Masamichi, Tanaka Chie, Yamada Suguru, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    CANCER SCIENCE   Vol. 109   page: 765 - 765   2018.12

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  230. Pattern-specific Transcriptomics Identifies ASGR2 as a Predictor of Hematogenous Recurrence of Gastric Cancer Reviewed

    Tanaka Haruyoshi, Kanda Mitsuro, Suenaga Masaya, Hayashi Masamichi, Tanaka Chie, Yamada Suguru, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    CANCER SCIENCE   Vol. 109   page: 1128 - 1128   2018.12

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  231. A New Biomarker for Peritoneal Lavage Using Digital PCR in Patients with Pancreatic Ductal Adenocarcinoma

    Suenaga Masaya, Yamada Suguru, Hayashi Masamichi, Kanda Mitsuro, Tanaka Chie, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    CANCER SCIENCE   Vol. 109   page: 650-650   2018.12

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  232. FRAS1 expression reflects the malignancy potential of gastric cancer

    Umeda Shinichi, Kanda Mitsuro, Tanaka Chie, Yamada Suguru, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    CANCER SCIENCE   Vol. 109   page: 1128-1128   2018.12

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  233. Pattern-specific Transcriptomics Identifies ASGR2 as a Predictor of Hematogenous Recurrence of Gastric Cancer Reviewed

    Tanaka Haruyoshi, Kanda Mitsuro, Suenaga Masaya, Hayashi Masamichi, Tanaka Chie, Yamada Suguru, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    CANCER SCIENCE   Vol. 109   page: 1128-1128   2018.12

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  234. Homeobox C10 correlates with the malignant phenotype of gastric cancer and its recurrence and poor survival

    Miwa Takashi, Kanda Mitsuro, Tanaka Chie, Yamada Suguru, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    CANCER SCIENCE   Vol. 109   page: 1127-1127   2018.12

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  235. Cutting-edge evidence of adjuvant treatments for gastric cancer

    Shimizu Dai, Kanda Mitsuro, Kodera Yasuhiro, Sakamoto Junichi

    EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY   Vol. 12 ( 11 ) page: 1109 - 1122   2018.11

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    DOI: 10.1080/17474124.2018.1530985

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  236. A randomized phase II multicenter trial to explore efficacy of weekly intraperitoneal in comparison with intravenous paclitaxel administered immediately after gastrectomy to the patients with high risk of peritoneal recurrence: final results of the INPACT trial. Reviewed

    Takahashi N, Kanda M, Yoshikawa T, Takiguchi N, Fujitani K, Miyamoto K, Ito Y, Takayama O, Imano M, Mitsumori N, Sakamoto J, Morita S, Kodera Y

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   Vol. 21 ( 6 ) page: 1014 - 1023   2018.11

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    DOI: 10.1007/s10120-018-0817-y

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  237. Treatment strategy of intraperitoneal and systemic chemotherapy combined with gastrectomy for gastric cancer with peritoneal metastasis Reviewed

    Kobayashi Daisuke, Kanda Mitsuro, Tanaka Chie, Sonohara Fuminori, Suenaga Masaya, Takami Hideki, Hattori Norifumi, Niwa Yukiko, Hayashi Masamichi, Yamada Suguru, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 33   page: 98-98   2018.11

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  238. Treatment strategy of intraperitoneal and systemic chemotherapy combined with gastrectomy for gastric cancer with peritoneal metastasis

    Kobayashi Daisuke, Kanda Mitsuro, Tanaka Chie, Sonohara Fuminori, Suenaga Masaya, Takami Hideki, Hattori Norifumi, Niwa Yukiko, Hayashi Masamichi, Yamada Suguru, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 33   page: 98-98   2018.11

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  239. Significance of Preoperative Systemic Inflammation Score in Short-Term and Long-Term Outcomes of Patients with Pathological T2-4 Gastric Cancer After Radical Gastrectomy

    Sato Bin, Kanda Mitsuro, Tanaka Chie, Kobayashi Daisuke, Iwata Naoki, Hattori Norifumi, Suenaga Masaya, Hayashi Masamichi, Yamada Suguru, Murotani Kenta, Fujiwara Michitaka, Kodera Yasuhiro

    WORLD JOURNAL OF SURGERY   Vol. 42 ( 10 ) page: 3277-3285   2018.10

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    DOI: 10.1007/s00268-018-4597-7

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  240. Expression of sushi domain containing two reflects the malignant potential of gastric cancer. Reviewed

    Umeda S, Kanda M, Miwa T, Tanaka H, Tanaka C, Kobayashi D, Suenaga M, Hattori N, Hayashi M, Yamada S, Nakayama G, Fujiwara M, Kodera Y

    Cancer medicine   Vol. 7 ( 10 ) page: 5194 - 5204   2018.10

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    DOI: 10.1002/cam4.1793

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  241. SYT7 acts as a driver of hepatic metastasis formation of gastric cancer cells. Reviewed

    Kanda M, Tanaka H, Shimizu D, Miwa T, Umeda S, Tanaka C, Kobayashi D, Hattori N, Suenaga M, Hayashi M, Iwata N, Yamada S, Fujiwara M, Kodera Y

    Oncogene   Vol. 37 ( 39 ) page: 5355 - 5366   2018.9

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    DOI: 10.1038/s41388-018-0335-8

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  242. Comparison of the Survival Outcomes of Pancreatic Cancer and Intraductal Papillary Mucinous Neoplasms. Reviewed

    Yamada S, Fujii T, Hirakawa A, Takami H, Suenaga M, Hayashi M, Niwa Y, Hattori N, Iwata N, Kanda M, Tanaka C, Kobayashi D, Nakayama G, Koike M, Fujiwara M, Kodera Y

    Pancreas   Vol. 47 ( 8 ) page: 974 - 979   2018.9

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    DOI: 10.1097/MPA.0000000000001110

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  243. Synaptotagmin XIII expression and peritoneal metastasis in gastric cancer

    Kanda M., Shimizu D., Tanaka H., Tanaka C., Kobayashi D., Hayashi M., Takami H., Niwa Y., Yamada S., Fujii T., Sugimoto H., Kodera Y.

    BRITISH JOURNAL OF SURGERY   Vol. 105 ( 10 ) page: 1349-1358   2018.9

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    DOI: 10.1002/bjs.10876

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  244. Pattern-Specific Transcriptomics Identifies ASGR2 as a Predictor of Hematogenous Recurrence of Gastric Cancer Reviewed

    Tanaka Haruyoshi, Kanda Mitsuro, Miwa Takashi, Tanaka Chie, Kobayashi Daisuke, Umeda Shinichi, Shibata Masahiro, Suenaga Masaya, Hattori Norifumi, Hayashi Masamichi, Iwata Naoki, Yamada Suguru, Nakayama Goro, Fujiwara Michitaka, Kodera Yasuhiro

    MOLECULAR CANCER RESEARCH   Vol. 16 ( 9 ) page: 1420 - 1429   2018.9

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    DOI: 10.1158/1541-7786.MCR-17-0467

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  245. 大腸癌におけるAGAP3の分子生物学的意義の検討(Biological significance of ArfGAP with GTPase domain, ankyrin repeat and PH domain 3(AGAP3) in colorectal cancer(CRC)) Reviewed

    清水 大, 佐藤 晋彰, 増田 隆明, 大津 甫, 黒田 陽介, 江口 英利, 神田 光郎, 小寺 泰弘, 三森 功士

    日本癌学会総会記事   Vol. 77回   page: 2066 - 2066   2018.9

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  246. Efficacy of enteral nutrients containing beta-hydroxy-beta-methylbutyrate, glutamine, and arginine for the patients with anastomotic leakage after gastrectomy: study protocol of a multicenter phase II clinical trial Reviewed

    Kanda Mitsuro, Tanaka Chie, Murotani Kenta, Kobayashi Daisuke, Ito Seiji, Mochizuki Yoshinari, Ishigure Kiyoshi, Ishiyama Akiharu, Teramoto Hitoshi, Murai Toshifumi, Asada Takahiro, Matsushita Hidenobu, Fujiwara Michitaka, Kodera Yasuhiro

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 3 ) page: 351 - 355   2018.8

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    DOI: 10.18999/nagjms.80.3.351

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  247. Randomized Phase II Trial of CapOX plus Bevacizumab and CapIRI plus Bevacizumab as First-Line Treatment for Japanese Patients with Metastatic Colorectal Cancer (CCOG-1201 Study) Reviewed

    Nakayama Goro, Mitsuma Ayako, Sunagawa Yuki, Ishigure Kiyoshi, Yokoyama Hiroyuki, Matsui Takanori, Nakayama Hiroshi, Nakata Kazuhiko, Ishiyama Akiharu, Asada Takahiro, Umeda Shinichi, Ezaka Kazuhiro, Hattori Norifumi, Takami Hideki, Kobayashi Daisuke, Tanaka Chie, Kanda Mitsuro, Yamada Suguru, Koike Masahiko, Fujiwara Michitaka, Fujii Tsutomu, Murotani Kenta, Ando Yuichi, Kodera Yasuhiro

    ONCOLOGIST   Vol. 23 ( 8 ) page: 919 - 927   2018.8

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    DOI: 10.1634/theoncologist.2017-0640

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  248. Impact of the Controlling Nutritional Status Score on the Prognosis After Curative Resection of Pancreatic Ductal Adenocarcinoma Reviewed

    Kato Yoshiyasu, Yamada Suguru, Suenaga Masaya, Takami Hideki, Niwa Yukiko, Hayashi Masamichi, Iwata Naoki, Kanda Mitsuro, Tanaka Chie, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    PANCREAS   Vol. 47 ( 7 ) page: 823 - 829   2018.8

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    DOI: 10.1097/MPA.0000000000001105

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  249. Troponin I2 as a Specific Biomarker for Prediction of Peritoneal Metastasis in Gastric Cancer Reviewed

    Sawaki Koichi, Kanda Mitsuro, Miwa Takashi, Umeda Shinichi, Tanaka Haruyoshi, Tanaka Chie, Kobayashi Daisuke, Suenaga Masaya, Hattori Norifumi, Hayashi Masamichi, Yamada Suguru, Nakayama Goro, Fujiwara Michitaka, Kodera Yasuhiro

    ANNALS OF SURGICAL ONCOLOGY   Vol. 25 ( 7 ) page: 2083 - 2090   2018.7

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    DOI: 10.1245/s10434-018-6480-z

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  250. Risk Factors for Peritoneal Recurrence in Stage II to III Colon Cancer

    Mayanagi Shuhei, Kashiwabara Kosuke, Honda Michitaka, Oba Koji, Aoyama Toru, Kanda Mitsuro, Maeda Hiromichi, Hamada Chikuma, Sadahiro Sotaro, Sakamoto Junichi, Saji Shigetoyo, Yoshikawa Takaki

    DISEASES OF THE COLON & RECTUM   Vol. 61 ( 7 ) page: 803-808   2018.7

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    DOI: 10.1097/DCR.0000000000001002

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  251. Clinical Implications of Lysyl Oxidase-Like Protein 2 Expression in Pancreatic Cancer Reviewed

    Tanaka Nobutake, Yamada Suguru, Sonohara Fuminori, Suenaga Masaya, Hayashi Masamichi, Takami Hideki, Niwa Yukiko, Hattori Norifumi, Iwata Naoki, Kanda Mitsuro, Tanaka Chie, Kobayashi Daisuke, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Fujii Tsutomu, Kodera Yasuhiro

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 9846   2018.6

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    DOI: 10.1038/s41598-018-28253-9

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  252. Emerging evidence of the molecular landscape specific for hematogenous metastasis from gastric cancer Reviewed

    Shimizu Dai, Kanda Mitsuro, Kodera Yasuhiro

    WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY   Vol. 10 ( 6 ) page: 124 - 136   2018.6

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    DOI: 10.4251/wjgo.v10.i6.124

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  253. A novel dual-marker expression panel for easy and accurate risk stratification of patients with gastric cancer

    Kanda Mitsuro, Murotani Kenta, Tanaka Haruyoshi, Miwa Takashi, Umeda Shinichi, Tanaka Chie, Kobayashi Daisuke, Hayashi Masamichi, Hattori Norifumi, Suenaga Masaya, Yamada Suguru, Nakayama Goro, Fujiwara Michitaka, Kodera Yasuhiro

    CANCER MEDICINE   Vol. 7 ( 6 ) page: 2463-2471   2018.6

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    DOI: 10.1002/cam4.1522

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  254. Significance of Lysyl oxidase-like 2 gene expression on the epithelial-mesenchymal status of hepatocellular carcinoma Reviewed

    Ninomiya Go, Yamada Suguru, Hayashi Masamichi, Takeda Shigeomi, Suenaga Masaya, Takami Hideki, Kanda Mitsuro, Iwata Naoki, Niwa Yukiko, Tanaka Chie, Kobayashi Daisuke, Fujii Tsutomu, Nakayama Goro, Sugimoto Hiroyuki, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    ONCOLOGY REPORTS   Vol. 39 ( 6 ) page: 2664 - 2672   2018.6

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    DOI: 10.3892/or.2018.6349

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  255. Postoperative adalimumab maintenance therapy for Japanese patients with Crohn's disease: a single-center, single-arm phase II trial (CCOG-1107 study) Reviewed

    Asada Takahiro, Nakayama Goro, Tanaka Chie, Kobayashi Daisuke, Ezaka Kazuhiro, Hattori Norifumi, Kanda Mitsuro, Yamada Suguru, Koike Masahiko, Kodera Yasuhiro

    SURGERY TODAY   Vol. 48 ( 6 ) page: 609 - 617   2018.6

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    DOI: 10.1007/s00595-018-1634-y

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  256. IDENTIFICATION OF MOLECULES DRIVING HEPATIC METASTASIS FORMATION OF GASTRIC CANCER CELLS

    Kanda Mitsuro, Tanaka Chie, Kobayashi Daisuke, Suenaga Masaya, Takami Hideki, Hattori Norifumi, Niwa Yukiko, Hayashi Masamichi, Yamada Suguru, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    GUT   Vol. 67   page: A5-A5   2018.6

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    DOI: 10.1136/gutjnl-2018-IDDFabstracts.12

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  257. A phase II trial to evaluate the efficacy of panitumumab combined with fluorouracil-based chemotherapy for metastatic colorectal cancer: the PF trial Reviewed

    Munemoto Yoshinori, Kanda Mitsuro, Oba Koji, Kim Ho Min, Takemoto Hiroyoshi, Denda Tadamichi, Nagata Naoki, Takano Nao, Fukunaga Mutsumi, Kataoka Masato, Tokunaga Yukihiko, Sakamoto Junichi, Mishima Hideyuki

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   Vol. 81 ( 5 ) page: 829 - 838   2018.5

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    DOI: 10.1007/s00280-018-3556-1

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  258. Integrated multigene expression panel to prognosticate patients with gastric cancer.

    Kanda M, Murotani K, Tanaka H, Miwa T, Umeda S, Tanaka C, Kobayashi D, Hayashi M, Hattori N, Suenaga M, Yamada S, Nakayama G, Fujiwara M, Kodera Y

    Oncotarget   Vol. 9 ( 27 ) page: 18775-18785   2018.4

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    DOI: 10.18632/oncotarget.24661

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  259. Emerging evidence of molecular biomarkers in hepatocellular carcinoma. Reviewed

    Umeda S, Kanda M, Kodera Y

    Histology and histopathology   Vol. 33 ( 4 ) page: 343 - 355   2018.4

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    DOI: 10.14670/HH-11-936

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  260. Clinical Signatures of Mucinous and Poorly Differentiated Subtypes of Colorectal Adenocarcinomas by a Propensity Score Analysis of an Independent Patient Database from Three Phase III Trials

    Kanda Mitsuro, Oba Koji, Aoyama Toru, Kashiwabara Kosuke, Mayanagi Shuhei, Maeda Hiromichi, Honda Michitaka, Hamada Chikuma, Sadahiro Sotaro, Sakamoto Junichi, Saji Shigetoyo, Yoshikawa Takaki

    DISEASES OF THE COLON & RECTUM   Vol. 61 ( 4 ) page: 461-471   2018.4

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    DOI: 10.1097/DCR.0000000000001022

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  261. 門脈合併切除膵癌における脾静脈再建-するvsしない- しない Reviewed

    藤井 努, 服部 正嗣, 山田 豪, 猪川 祥邦, 神田 光郎, 高見 秀樹, 吉岡 伊作, 渋谷 和人, 奥村 知之, 中尾 昭公, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 118回   page: 743 - 743   2018.4

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  262. Significance of SYT8 For the Detection, Prediction, and Treatment of Peritoneal Metastasis From Gastric Cancer. Reviewed

    Kanda M, Shimizu D, Tanaka H, Tanaka C, Kobayashi D, Hayashi M, Iwata N, Niwa Y, Yamada S, Fujii T, Sugimoto H, Murotani K, Fujiwara M, Kodera Y

    Annals of surgery   Vol. 267 ( 3 ) page: 495 - 503   2018.3

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    DOI: 10.1097/SLA.0000000000002096

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  263. Preoperative Albumin-Bilirubin Grade Predicts Recurrences After Radical Gastrectomy in Patients with pT2-4 Gastric Cancer. Reviewed

    Kanda M, Tanaka C, Kobayashi D, Uda H, Inaoka K, Tanaka Y, Hayashi M, Iwata N, Yamada S, Fujii T, Sugimoto H, Murotani K, Fujiwara M, Kodera Y

    World journal of surgery   Vol. 42 ( 3 ) page: 773 - 781   2018.3

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    DOI: 10.1007/s00268-017-4234-x

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  264. Identification of a novel molecule target for the diagnosis, prediction, and treatment of hepatic metastasis of gastric cancer. Reviewed

    Kanda Mitsuro, Tanaka Haruyoshi, Miwa Takashi, Kobayashi Daisuke, Tanaka Chie, Takami Hideki, Hayashi Masamichi, Iwata Naoki, Niwa Yukiko, Yamada Suguru, Nakayama Goro, Sugimoto Hiroyuki, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 36 ( 4 ) page: .   2018.2

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  265. Phase I study of chemoradiotherapy using gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic cancer. Reviewed

    Yamada Suguru, Fujii Tsutomu, Takano Nao, Takami Hideki, Suenaga Masaya, Niwa Yukiko, Hayashi Masamichi, Iwata Naoki, Kanda Mitsuro, Kobayashi Daisuke, Tanaka Chie, Nakayama Goro, Sugimoto Hiroyuki, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 36 ( 4 ) page: .   2018.2

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  266. Clinical implication of nutrition for neoadjuvant therapy and impact of nutritional support in pancreatic cancer. Reviewed

    Tashiro Mitsuru, Yamada Suguru, Fujii Tsutomu, Hattori Norifumi, Takami Hideki, Suenaga Masaya, Niwa Yukiko, Hayashi Masamichi, Iwata Naoki, Kanda Mitsuro, Tanaka Chie, Kobayashi Daisuke, Nakayama Goro, Sugimoto Hiroyuki, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 36 ( 4 )   2018.2

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  267. Clinical implication of nutrition for neoadjuvant therapy and impact of nutritional support in pancreatic cancer.

    Tashiro Mitsuru, Yamada Suguru, Fujii Tsutomu, Hattori Norifumi, Takami Hideki, Suenaga Masaya, Niwa Yukiko, Hayashi Masamichi, Iwata Naoki, Kanda Mitsuro, Tanaka Chie, Kobayashi Daisuke, Nakayama Goro, Sugimoto Hiroyuki, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 36 ( 4 ) page: .   2018.2

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  268. Identification of a novel molecule target for the diagnosis, prediction, and treatment of hepatic metastasis of gastric cancer.

    Kanda Mitsuro, Tanaka Haruyoshi, Miwa Takashi, Kobayashi Daisuke, Tanaka Chie, Takami Hideki, Hayashi Masamichi, Iwata Naoki, Niwa Yukiko, Yamada Suguru, Nakayama Goro, Sugimoto Hiroyuki, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 36 ( 4 ) page: .   2018.2

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  269. Phase I study of chemoradiotherapy using gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic cancer.

    Yamada Suguru, Fujii Tsutomu, Takano Nao, Takami Hideki, Suenaga Masaya, Niwa Yukiko, Hayashi Masamichi, Iwata Naoki, Kanda Mitsuro, Kobayashi Daisuke, Tanaka Chie, Nakayama Goro, Sugimoto Hiroyuki, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 36 ( 4 ) page: .   2018.2

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  270. Review of recent molecular landscape knowledge of gastric cancer. Reviewed

    Shimizu D, Kanda M, Kodera Y

    Histology and histopathology   Vol. 33 ( 1 ) page: 11 - 26   2018.1

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    DOI: 10.14670/HH-11-898

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  271. Effectiveness of plasma activated lactated Ringer's solution on pancreatic cancer cells in vitro and in vivo

    Sato Yusuke, Yamada Suguru, Takeda Shigeomi, Kanda Mitsuo, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    CANCER SCIENCE   Vol. 109   page: 707-707   2018.1

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  272. Oncogenic function of miR-23b-3p in hepatocellular carcinoma

    Masamichi Hayashi, Yamada Suguru, Kanda Mitsuro, Tanaka Chie, Fujiwara Michitaka, Kodera Yasuhiro

    CANCER SCIENCE   Vol. 109   page: 1123-1123   2018.1

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  273. Nutritional Recovery after Open and Laparoscopic Distal Gastrectomy for Early Gastric Cancer: A Prospective Multicenter Comparative Trial (CCOG1204). Reviewed

    Matsushita H, Tanaka C, Murotani K, Misawa K, Ito S, Ito Y, Kanda M, Mochizuki Y, Ishigure K, Yaguchi T, Teramoto J, Nakayama H, Kawase Y, Fujiwara M, Kodera Y

    Digestive surgery   Vol. 35 ( 1 ) page: 11 - 18   2018

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    DOI: 10.1159/000458714

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  274. Perioperative Serum Carcinoembryonic Antigen Levels Predict Recurrence and Survival of Patients with Pathological T2-4 Gastric Cancer Treated with Curative Gastrectomy. Reviewed

    Uda H, Kanda M, Tanaka C, Kobayashi D, Inaoka K, Tanaka Y, Hayashi M, Iwata N, Yamada S, Fujii T, Sugimoto H, Murotani K, Fujiwara M, Kodera Y

    Digestive surgery   Vol. 35 ( 1 ) page: 55 - 63   2018

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    DOI: 10.1159/000471931

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  275. Review of recent efforts to discover biomarkers for early detection, monitoring, prognosis, and prediction of treatment responses of patients with gastric cancer Reviewed

    Sawaki Koichi, Kanda Mitsuro, Kodera Yasuhiro

    EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY   Vol. 12 ( 7 ) page: 657 - 670   2018

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    DOI: 10.1080/17474124.2018.1489233

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  276. Prognostic Impact of Portal System Invasion in Pancreatic Cancer Based on Image Classification

    Morimoto Daishi, Yamada Suguru, Murotani Kenta, Sonohara Fuminori, Takami Hideki, Suenaga Masaya, Hayashi Masamichi, Niwa Yukiko, Tashiro Mitsuru, Hattori Norifumi, Iwata Naoki, Kanda Mitsuro, Tanaka Chie, Kobayashi Daisuke, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Fujii Tsutomu, Kodera Yasuhiro

    PANCREAS   Vol. 47 ( 10 ) page: 1350 - 1356   2018

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    DOI: 10.1097/MPA.0000000000001186

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  277. Randomized phase II study of daily and alternate-day administration of S-1 for advanced gastric cancer (JFMC43-1003) Reviewed

    Tanaka Hiroaki, Kanda Mitsuro, Morita Satoshi, Taguri Masataka, Nishikawa Kazuhiro, Shimada Mitsuo, Muguruma Kazuya, Koeda Keisuke, Takahashi Masazumi, Nakamori Mikihito, Konno Hiroyuki, Tsuji Akihito, Hosoya Yoshinori, Shirasaka Tetsuhiko, Yamamitsu Susumu, Sowa Michio, Kitajima Masaki, Okajima Masazumi, Kobayashi Michiya, Sakamoto Junichi, Saji Shigetoyo, Hirakawa Kosei

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 22 ( 6 ) page: 1052 - 1059   2017.12

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    DOI: 10.1007/s10147-017-1157-3

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  278. Prevalence of Helicobacter Pylori Infection in Dyspeptic Patients in Andkhoy Afghanistan

    Hamrah MH, Hamrah MS, Hassan Hamrah M, Kanda M, Hamrah AE, Dahi AE, Homayoun F, Hamrah MH, Fotouhi A, Sakamoto J

    Asian Pacific journal of cancer prevention : APJCP   Vol. 18 ( 11 ) page: 3123-3127   2017.11

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    DOI: 10.22034/APJCP.2017.18.11.3123

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  279. Development and validation of a prognostic nomogram for colorectal cancer after radical resection based on individual patient data from three large-scale phase III trials Reviewed

    Honda Michitaka, Oba Koji, Akiyoshi Takashi, Maeda Hiromichi, Kashiwabara Kosuke, Kanda Mitsuro, Mayanagi Shuhei, Aoyama Toru, Hamada Chikuma, Sadahiro Sotaro, Fukunaga Yosuke, Ueno Masashi, Sakamoto Junichi, Saji Shigetoyo, Yoshikawa Takaki

    ONCOTARGET   Vol. 8 ( 58 ) page: 99150 - 99160   2017.11

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    DOI: 10.18632/oncotarget.21845

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  280. FBXO50 Enhances the Malignant Behavior of Gastric Cancer Cells. Reviewed

    Miwa T, Kanda M, Tanaka H, Tanaka C, Kobayashi D, Umeda S, Iwata N, Hayashi M, Yamada S, Fujii T, Fujiwara M, Kodera Y

    Annals of surgical oncology   Vol. 24 ( 12 ) page: 3771 - 3779   2017.11

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    DOI: 10.1245/s10434-017-5882-7

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  281. Clinical impact of postoperative surgical complications on the colorectal cancer survival and recurrence: Analyses of pooled individual patients' data from three large phase III randomized trials

    Aoyama T., Oba K., Honda M., Sadahiro S., Hamada C., Mayanagi S., Kanda M., Maeda H., Sakamoto J., Saji S., Yoshikawa T.

    ANNALS OF ONCOLOGY   Vol. 28   page: .   2017.11

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  282. Clinical impact of tumor location on the colon cancer survival and recurrence: analyses of pooled data from three large phase III randomized clinical trials

    Aoyama Toru, Kashiwabara Kosuke, Oba Koji, Honda Michitaka, Sadahiro Sotaro, Hamada Chikuma, Maeda Hiromichi, Mayanagi Shuhei, Kanda Mitsuro, Sakamoto Junichi, Saji Shigetoyo, Yoshikawa Takaki

    CANCER MEDICINE   Vol. 6 ( 11 ) page: 2523-2530   2017.11

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    DOI: 10.1002/cam4.1208

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  283. FAM46C Serves as a Predictor of Hepatic Recurrence in Patients with Resectable Gastric Cancer. Reviewed

    Tanaka H, Kanda M, Shimizu D, Tanaka C, Kobayashi D, Hayashi M, Iwata N, Yamada S, Fujii T, Nakayama G, Sugimoto H, Fujiwara M, Niwa Y, Kodera Y

    Annals of surgical oncology   Vol. 24 ( 11 ) page: 3438 - 3445   2017.10

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    DOI: 10.1245/s10434-016-5636-y

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  284. Identification of <i>NCCRP1</i> as an epigenetically regulated tumor suppressor and biomarker for malignant phenotypes of squamous cell carcinoma of the esophagus. Reviewed

    Miwa T, Kanda M, Koike M, Iwata N, Tanaka H, Umeda S, Tanaka C, Kobayashi D, Hayashi M, Yamada S, Fujii T, Fujiwara M, Kodera Y

    Oncology letters   Vol. 14 ( 4 ) page: 4822 - 4828   2017.10

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    DOI: 10.3892/ol.2017.6753

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  285. Evaluation and proposal of novel resectability criteria for pancreatic cancer established by the Japan Pancreas Society. Reviewed

    Yamada S, Fujii T, Takami H, Hayashi M, Iwata N, Kanda M, Tanaka C, Sugimoto H, Nakayama G, Koike M, Fujiwara M, Kodera Y

    Surgery   Vol. 162 ( 4 ) page: 784 - 791   2017.10

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    DOI: 10.1016/j.surg.2017.04.023

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  286. An integrated multigene expression panel to predict long-term survival after curative hepatectomy in patients with hepatocellular carcinoma. Reviewed

    Kanda M, Murotani K, Sugimoto H, Miwa T, Umeda S, Suenaga M, Hayashi M, Hattori N, Tanaka C, Kobayashi D, Yamada S, Fujiwara M, Kodera Y

    Oncotarget   Vol. 8 ( 41 ) page: 71070 - 71079   2017.9

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    DOI: 10.18632/oncotarget.20369

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  287. Downregulation of GPR155 as a prognostic factor after curative resection of hepatocellular carcinoma. Reviewed

    Umeda S, Kanda M, Sugimoto H, Tanaka H, Hayashi M, Yamada S, Fujii T, Takami H, Niwa Y, Iwata N, Tanaka C, Kobayashi D, Fujiwara M, Kodera Y

    BMC cancer   Vol. 17 ( 1 ) page: 610   2017.9

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    DOI: 10.1186/s12885-017-3629-2

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  288. Overexpression of Derlin 3 is associated with malignant phenotype of breast cancer cells. Reviewed

    Shibata M, Kanda M, Tanaka H, Umeda S, Miwa T, Shimizu D, Hayashi M, Inaishi T, Miyajima N, Adachi Y, Takano Y, Nakanishi K, Takeuchi D, Noda S, Kodera Y, Kikumori T

    Oncology reports   Vol. 38 ( 3 ) page: 1760 - 1766   2017.9

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    DOI: 10.3892/or.2017.5800

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  289. Involvement of the immunoregulator MZB1 in progression of gastric cancer

    Tanaka Y., Kanda M., Tanaka C., Kobayashi D., Tanaka H., Takami H., Hayashi M., Iwata N., Niwa Y., Yamada S., Nakayama G., Sugimoto H., Koike M., Fujiwara M., Kodera Y.

    ANNALS OF ONCOLOGY   Vol. 28   page: .   2017.9

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  290. Nutritional recovery after open and laparoscopic distal gastrectomy for early gastric cancer: A prospective multicenter comparative trial (CCOG1204)

    Tanaka C., Kanda M., Misawa K., Ito S., Ito Y., Mochizuki Y., Ishigure K., Yaguchi T., Teramoto J., Nakayama H., Kawase Y., Fujiwara M., Kodera Y.

    ANNALS OF ONCOLOGY   Vol. 28   page: .   2017.9

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  291. Usefulness of preoperative estimated glomerular filtration rate to predict complications after curative gastrectomy in patients with clinical T2-4 gastric cancer. Reviewed

    Tanaka Y, Kanda M, Tanaka C, Kobayashi D, Mizuno A, Iwata N, Hayashi M, Niwa Y, Takami H, Yamada S, Fujii T, Nakayama G, Sugimoto H, Fujiwara M, Kodera Y

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   Vol. 20 ( 4 ) page: 736 - 743   2017.7

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    DOI: 10.1007/s10120-016-0657-6

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  292. Impact of postoperative complications on the colorectal cancer survival and recurrence: analyses of pooled individual patients' data from three large phase III randomized trials

    Aoyama Toru, Oba Koji, Honda Michitaka, Sadahiro Sotaro, Hamada Chikuma, Mayanagi Shuhei, Kanda Mitsuro, Maeda Hiromichi, Kashiwabara Kosuke, Sakamoto Junichi, Saji Shigetoyo, Yoshikawa Takaki

    CANCER MEDICINE   Vol. 6 ( 7 ) page: 1573-1580   2017.7

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    DOI: 10.1002/cam4.1126

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  293. Expression of regulatory factor X1 can predict the prognosis of breast cancer. Reviewed

    Shibata M, Kanda M, Shimizu D, Tanaka H, Umeda S, Hayashi M, Inaishi T, Miyajima N, Adachi Y, Takano Y, Nakanishi K, Takeuchi D, Noda S, Kodera Y, Kikumori T

    Oncology letters   Vol. 13 ( 6 ) page: 4334 - 4340   2017.6

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    DOI: 10.3892/ol.2017.6005

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  294. Stapling an extracorporeal Billroth-I anastomosis by the complete double stapling technique after laparoscopy-assisted distal gastrectomy. Reviewed

    Tanaka C, Fujiwara M, Kanda M, Murotani K, Iwata N, Hayashi M, Kobayashi D, Yamada S, Nakayama G, Sugimoto H, Koike M, Fujii T, Kodera Y

    Asian journal of endoscopic surgery   Vol. 10 ( 2 ) page: 137 - 142   2017.5

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    DOI: 10.1111/ases.12357

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  295. Intraperitoneal Administration of Plasma-Activated Medium: Proposal of a Novel Treatment Option for Peritoneal Metastasis From Gastric Cancer. Reviewed

    Takeda S, Yamada S, Hattori N, Nakamura K, Tanaka H, Kajiyama H, Kanda M, Kobayashi D, Tanaka C, Fujii T, Fujiwara M, Mizuno M, Hori M, Kodera Y

    Annals of surgical oncology   Vol. 24 ( 5 ) page: 1188 - 1194   2017.5

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    DOI: 10.1245/s10434-016-5759-1

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  296. Clinical utility of the platelet-lymphocyte ratio as a predictor of postoperative complications after radical gastrectomy for clinical T2-4 gastric cancer. Reviewed

    Inaoka K, Kanda M, Uda H, Tanaka Y, Tanaka C, Kobayashi D, Takami H, Iwata N, Hayashi M, Niwa Y, Yamada S, Fujii T, Sugimoto H, Murotani K, Fujiwara M, Kodera Y

    World journal of gastroenterology   Vol. 23 ( 14 ) page: 2519 - 2526   2017.4

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    DOI: 10.3748/wjg.v23.i14.2519

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  297. The efficacy and safety of CapeOX plus bevacizumab therapy followed by capecitabine plus bevacizumab maintenance therapy in patients with metastatic colorectal cancer: a multi-center, single-arm, phase II study (CCOG-0902). Reviewed

    Nakayama G, Ishigure K, Yokoyama H, Uehara K, Kojima H, Ishiyama A, Hayashi N, Takano N, Hattori N, Kobayashi D, Tanaka C, Hayashi M, Kanda M, Yamada S, Sugimoto H, Koike M, Fujiwara M, Fujii T, Murotani K, Ando Y, Kodera Y

    BMC cancer   Vol. 17 ( 1 ) page: 243   2017.4

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    DOI: 10.1186/s12885-017-3245-1

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  298. Clinical impact of sarcopenia on prognosis in pancreatic ductal adenocarcinoma: A retrospective cohort study. Reviewed

    Ninomiya G, Fujii T, Yamada S, Yabusaki N, Suzuki K, Iwata N, Kanda M, Hayashi M, Tanaka C, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y

    International journal of surgery (London, England)   Vol. 39   page: 45 - 51   2017.3

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    DOI: 10.1016/j.ijsu.2017.01.075

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  299. GPR155 Serves as a Predictive Biomarker for Hematogenous Metastasis in Patients with Gastric Cancer. Reviewed

    Shimizu D, Kanda M, Tanaka H, Kobayashi D, Tanaka C, Hayashi M, Iwata N, Niwa Y, Takami H, Yamada S, Fujii T, Nakayama G, Fujiwara M, Kodera Y

    Scientific reports   Vol. 7   page: 42089   2017.2

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    DOI: 10.1038/srep42089

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  300. Esophageal Cancer and associated Factors among Uzbek-Turkmen and Other Ethnic Groups in the Northern Part of Afghanistan

    Hamrah MH, Hamrah MSh, Kanda M, Sakamoto J, Hamrah MH, Hami A, Hamrah AE, Dahi AE, Hamrah MH

    Asian Pacific journal of cancer prevention : APJCP   Vol. 18 ( 2 ) page: 333-337   2017.2

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    DOI: 10.22034/APJCP.2017.18.2.333

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  301. Clinical impact of sarcopenia on prognosis in pancreatic ductal adenocarcinoma. Reviewed

    Ninomiya Go, Fujii Tsutomu, Yamada Suguru, Asano Tomonari, Takano Nao, Takami Hideki, Iwata Naoki, Kanda Mitsuro, Niwa Yukiko, Hayashi Masamichi, Kobayashi Daisuke, Tanaka Chie, Nakayama Goro, Sugimoto Hiroyuki, Fujiwara Michitaka, Koike Masahiko, Kodera Yasuhiro

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 35 ( 4 )   2017.2

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  302. Tumor infiltrative pattern predicts sites of recurrence after curative gastrectomy for gastric cancer.

    Kanda Mitsuro, Kobayashi Daisuke, Tanaka Chie, Yamada Suguru, Fujii Tsutomu, Nakayama Goro, Sugimoto Hiroyuki, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 35 ( 4 )   2017.2

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    DOI: 10.1200/JCO.2017.35.4_suppl.38

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  303. Conversion surgery for unresectable gastric cancer following complete response of distant metastasis by systemic chemotherapy. Reviewed

    Kobayashi Daisuke, Kanda Mitsuro, Tanaka Chie, Iwata Naoki, Hayashi Masamichi, Yamada Suguru, Nakayama Goro, Sugimoto Hiroyuki, Koike Masahiko, Fujii Tsutomu, Fujiwara Michitaka, Kodera Yasuhiro

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 35 ( 4 )   2017.2

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  304. Clinical implication of inflammation-based prognostic score and perioperative nutrition control in pancreatic cancer. Reviewed

    Takano Nao, Yamada Suguru, Fujii Tsutomu, Tashiro Mitsuru, Tanaka Nobutake, Morimoto Daishi, Ninomiya Go, Niwa Yukiko, Takami Hideki, Iwata Naoki, Hayashi Masamichi, Kanda Mitsuro, Tanaka Chie, Kobayashi Daisuke, Nakayama Goro, Sugimoto Hiroyuki, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 35 ( 4 )   2017.2

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  305. Inverse probability of treatment weighting analysis of upfront surgery versus neoadjuvant chemoradiotherapy followed by surgery for pancreatic adenocarcinoma with arterial abutment. Reviewed

    Fujii Tsutomu, Yamada Suguru, Murotani Kenta, Takami Hideki, Hayashi Masamichi, Kanda Mitsuro, Nakayama Goro, Sugimoto Hiroyuki, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 35 ( 4 )   2017.2

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  306. The efficacy and safety of CapeOX plus bevacizumab therapy with a planned oxaliplatin stop-and-go strategy in patients with metastatic colorectal cancer: A multicenter, single-arm, phase II study (CCOG-0902 study). Reviewed

    Sunakawa Yuuki, Nakayama Goro, Ishigure Kiyoshi, Yokoyama Hiroyuki, Uehara Keisuke, Kanda Mitsuro, Murotani Kenta, Fujii Tsutomu, Kodera Yasuhiro

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 35 ( 4 )   2017.2

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  307. Clinical impact of sarcopenia on prognosis in pancreatic ductal adenocarcinoma.

    Ninomiya Go, Fujii Tsutomu, Yamada Suguru, Asano Tomonari, Takano Nao, Takami Hideki, Iwata Naoki, Kanda Mitsuro, Niwa Yukiko, Hayashi Masamichi, Kobayashi Daisuke, Tanaka Chie, Nakayama Goro, Sugimoto Hiroyuki, Fujiwara Michitaka, Koike Masahiko, Kodera Yasuhiro

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 35 ( 4 ) page: .   2017.2

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  308. Conversion surgery for unresectable gastric cancer following complete response of distant metastasis by systemic chemotherapy.

    Kobayashi Daisuke, Kanda Mitsuro, Tanaka Chie, Iwata Naoki, Hayashi Masamichi, Yamada Suguru, Nakayama Goro, Sugimoto Hiroyuki, Koike Masahiko, Fujii Tsutomu, Fujiwara Michitaka, Kodera Yasuhiro

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 35 ( 4 ) page: .   2017.2

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  309. The COMET Open-label Phase II Study of Neoadjuvant FOLFOX or XELOX Treatment Combined with Molecular Targeting Monoclonal Antibodies in Patients with Resectable Liver Metastasis of Colorectal Cancer. Reviewed

    Kataoka M, Kanda M, Ishigure K, Matsuoka H, Sato Y, Takahashi T, Tanaka C, Deguchi T, Shibata Y, Sato M, Inagaki H, Matsui T, Kondo A, Takano N, Tanaka H, Sakamoto J, Oba K, Kondo K

    Annals of surgical oncology   Vol. 24 ( 2 ) page: 546 - 553   2017.2

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    DOI: 10.1245/s10434-016-5557-9

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  310. Proposal of the Coagulation Score as a Predictor for Short-Term and Long-Term Outcomes of Patients with Resectable Gastric Cancer. Reviewed

    Kanda M, Tanaka C, Kobayashi D, Mizuno A, Tanaka Y, Takami H, Iwata N, Hayashi M, Niwa Y, Yamada S, Fujii T, Sugimoto H, Murotani K, Fujiwara M, Kodera Y

    Annals of surgical oncology   Vol. 24 ( 2 ) page: 502 - 509   2017.2

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    DOI: 10.1245/s10434-016-5544-1

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  311. The protein arginine methyltransferase 5 promotes malignant phenotype of hepatocellular carcinoma cells and is associated with adverse patient outcomes after curative hepatectomy. Reviewed

    Shimizu D, Kanda M, Sugimoto H, Shibata M, Tanaka H, Takami H, Iwata N, Hayashi M, Tanaka C, Kobayashi D, Yamada S, Nakayama G, Koike M, Fujiwara M, Fujii T, Kodera Y

    International journal of oncology   Vol. 50 ( 2 ) page: 381 - 386   2017.2

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    DOI: 10.3892/ijo.2017.3833

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  312. Association of Inflammasome Components in Background Liver with Poor Prognosis After Curatively-resected Hepatocellular Carcinoma. Reviewed

    Sonohara F, Inokawa Y, Kanda M, Nishikawa Y, Yamada S, Fujii T, Sugimoto H, Kodera Y, Nomoto S

    Anticancer research   Vol. 37 ( 1 ) page: 293 - 300   2017.1

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    DOI: 10.21873/anticanres.11320

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  313. Clinical benefits of neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreatic head: an observational study using inverse probability of treatment weighting. Reviewed

    Fujii T, Satoi S, Yamada S, Murotani K, Yanagimoto H, Takami H, Yamamoto T, Kanda M, Yamaki S, Hirooka S, Kon M, Kodera Y

    Journal of gastroenterology   Vol. 52 ( 1 ) page: 81 - 93   2017.1

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    DOI: 10.1007/s00535-016-1217-x

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  314. PAX5 gene as a novel methylation marker that predicts both clinical outcome and cisplatin sensitivity in esophageal squamous cell carcinoma. Reviewed

    Kurimoto K, Hayashi M, Guerrero-Preston R, Koike M, Kanda M, Hirabayashi S, Tanabe H, Takano N, Iwata N, Niwa Y, Takami H, Kobayashi D, Tanaka C, Yamada S, Nakayama G, Sugimoto H, Fujii T, Fujiwara M, Kodera Y

    Epigenetics   Vol. 12 ( 10 ) page: 865 - 874   2017

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    DOI: 10.1080/15592294.2017.1365207

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  315. Hazard rate of tumor recurrence over time in patients with colon cancer: implications for postoperative surveillance from three Japanese Foundation for Multi-disciplinary Treatment of Cancer (JFMC) clinical trials

    Maeda Hiromichi, Kashiwabara Kosuke, Aoyama Toru, Oba Koji, Honda Michitaka, Mayanagi Shuhei, Kanda Mitsuro, Hamada Chikuma, Sadahiro Sotaro, Sakamoto Junichi, Saji Shigetoyo, Yoshikawa Takaki

    JOURNAL OF CANCER   Vol. 8 ( 19 ) page: 4057-4064   2017

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    DOI: 10.7150/jca.21365

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  316. Pharmacokinetic dose adjustment of 5-FU in modified FOLFOX7 plus bevacizumab for metastatic colorectal cancer in Japanese patients: a-JUST phase II clinical trial. Reviewed

    Denda T, Kanda M, Morita Y, Kim HM, Kashiwada T, Matsuda C, Fujieda S, Nakata K, Murotani K, Oba K, Sakamoto J, Mishima H

    Cancer chemotherapy and pharmacology   Vol. 78 ( 6 ) page: 1253-1261   2016.12

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    DOI: 10.1007/s00280-016-3184-6

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  317. Prognostic significance of AKR1B10 gene expression in hepatocellular carcinoma and surrounding non-tumorous liver tissue.

    Sonohara F, Inokawa Y, Hishida M, Kanda M, Nishikawa Y, Yamada S, Fujii T, Sugimoto H, Kodera Y, Nomoto S

    Oncology letters   Vol. 12 ( 6 ) page: 4821-4828   2016.12

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    DOI: 10.3892/ol.2016.5240

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  318. Lymph node ratio as parameter of regional lymph node involvement in pancreatic cancer.

    Yamada S, Fujii T, Hirakawa A, Kanda M, Sugimoto H, Kodera Y

    Langenbeck's archives of surgery   Vol. 401 ( 8 ) page: 1143-1152   2016.12

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    DOI: 10.1007/s00423-016-1412-5

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  319. A resected case of symptomatic acinar cell cystadenoma of the pancreas displacing the main pancreatic duct.

    Tanaka H, Hatsuno T, Kinoshita M, Hasegawa K, Ishihara H, Takano N, Shimoyama S, Nakayama H, Kataoka M, Ichihara S, Kanda M, Kodera Y, Kondo K

    Surgical case reports   Vol. 2 ( 1 ) page: 39   2016.12

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    DOI: 10.1186/s40792-016-0166-1

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  320. Prognostic relevance of <i>SAMSN1</i> expression in gastric cancer.

    Kanda M, Shimizu D, Sueoka S, Nomoto S, Oya H, Takami H, Ezaka K, Hashimoto R, Tanaka Y, Kobayashi D, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y

    Oncology letters   Vol. 12 ( 6 ) page: 4708-4716   2016.12

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    DOI: 10.3892/ol.2016.5233

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  321. Erratum to: The COMET Open-label Phase II Study of Neoadjuvant FOLFOX or XELOX Treatment Combined with Molecular Targeting Monoclonal Antibodies in Patients with Resectable Liver Metastasis of Colorectal Cancer. Reviewed

    Kataoka M, Kanda M, Ishigure K, Matsuoka H, Sato Y, Takahashi T, Tanaka C, Deguchi T, Shibata Y, Sato M, Inagaki H, Matsui T, Kondo A, Takano N, Tanaka H, Sakamoto J, Oba K, Kondo K

    Annals of surgical oncology   Vol. 23 ( Suppl 5 ) page: 1064   2016.12

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    DOI: 10.1245/s10434-016-5593-5

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  322. Epigenetic suppression of the immunoregulator MZB1 is associated with the malignant phenotype of gastric cancer. Reviewed

    Kanda M, Tanaka C, Kobayashi D, Tanaka H, Shimizu D, Shibata M, Takami H, Hayashi M, Iwata N, Niwa Y, Yamada S, Fujii T, Nakayama G, Fujiwara M, Kodera Y

    International journal of cancer   Vol. 139 ( 10 ) page: 2290-8   2016.11

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    DOI: 10.1002/ijc.30286

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  323. Molecular alterations in the carcinogenesis and progression of hepatocellular carcinoma: Tumor factors and background liver factors.

    Inokawa Y, Inaoka K, Sonohara F, Hayashi M, Kanda M, Nomoto S

    Oncology letters   Vol. 12 ( 5 ) page: 3662-3668   2016.11

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    DOI: 10.3892/ol.2016.5141

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  324. Predictive value of drain amylase content for peripancreatic inflammatory fluid collections after laparoscopic (assisted) distal gastrectomy. Reviewed

    Kanda M, Fujiwara M, Tanaka C, Kobayashi D, Iwata N, Mizuno A, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Kodera Y

    Surgical endoscopy   Vol. 30 ( 10 ) page: 4353-62   2016.10

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    DOI: 10.1007/s00464-016-4753-9

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  325. Modified two-dimensional response as surrogate marker of overall survival in patients with metastatic colorectal cancer.

    Nakayama G, Fujii T, Murotani K, Uehara K, Hattori N, Hayashi M, Tanaka C, Kobayashi D, Kanda M, Yamada S, Sugimoto H, Koike M, Fujiwara M, Ando Y, Kodera Y

    Cancer science   Vol. 107 ( 10 ) page: 1492-1498   2016.10

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    DOI: 10.1111/cas.13023

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  326. Protein arginine methyltransferase 5 is associated with malignant phenotype and peritoneal metastasis in gastric cancer. Reviewed

    Kanda M, Shimizu D, Fujii T, Tanaka H, Shibata M, Iwata N, Hayashi M, Kobayashi D, Tanaka C, Yamada S, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y

    International journal of oncology   Vol. 49 ( 3 ) page: 1195-202   2016.9

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    DOI: 10.3892/ijo.2016.3584

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  327. Correlation Between Poor Prognosis and Lower TPPP Gene Expression in Hepatocellular Carcinoma.

    Inokawa Y, Sonohara F, Kanda M, Hayashi M, Nishikawa Y, Sugimoto H, Kodera Y, Nomoto S

    Anticancer research   Vol. 36 ( 9 ) page: 4639-45   2016.9

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    DOI: 10.21873/anticanres.11014

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  328. Molecular mechanisms of peritoneal dissemination in gastric cancer. Reviewed

    Kanda M, Kodera Y

    World journal of gastroenterology   Vol. 22 ( 30 ) page: 6829-40   2016.8

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    DOI: 10.3748/wjg.v22.i30.6829

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  329. Neurotrophin Receptor-Interacting Melanoma Antigen-Encoding Gene Homolog is Associated with Malignant Phenotype of Gastric Cancer. Reviewed

    Kanda M, Shimizu D, Fujii T, Tanaka H, Tanaka Y, Ezaka K, Shibata M, Takami H, Hashimoto R, Sueoka S, Iwata N, Kobayashi D, Tanaka C, Yamada S, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y

    Annals of surgical oncology   Vol. 23 ( Suppl 4 ) page: 532-539   2016.8

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    DOI: 10.1245/s10434-016-5375-0

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  330. The significance of relative dose intensity in adjuvant chemotherapy of pancreatic ductal adenocarcinoma-including the analysis of clinicopathological factors influencing relative dose intensity.

    Yabusaki N, Fujii T, Yamada S, Murotani K, Sugimoto H, Kanda M, Nakayama G, Koike M, Fujiwara M, Kodera Y

    Medicine   Vol. 95 ( 29 ) page: e4282   2016.7

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    DOI: 10.1097/MD.0000000000004282

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  331. Overexpression of ankyrin1 promotes pancreatic cancer cell growth. Reviewed

    Omura N, Mizuma M, MacGregor A, Hong SM, Ayars M, Almario JA, Borges M, Kanda M, Li A, Vincent A, Maitra A, Goggins M

    Oncotarget   Vol. 7 ( 23 ) page: 34977-87   2016.6

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    DOI: 10.18632/oncotarget.9009

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  332. Nutritional predictors for postoperative short-term and long-term outcomes of patients with gastric cancer. Reviewed

    Kanda M, Mizuno A, Tanaka C, Kobayashi D, Fujiwara M, Iwata N, Hayashi M, Yamada S, Nakayama G, Fujii T, Sugimoto H, Koike M, Takami H, Niwa Y, Murotani K, Kodera Y

    Medicine   Vol. 95 ( 24 ) page: e3781   2016.6

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    DOI: 10.1097/MD.0000000000003781

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  333. Tumor Infiltrative Pattern Predicts Sites of Recurrence After Curative Gastrectomy for Stages 2 and 3 Gastric Cancer. Reviewed

    Kanda M, Mizuno A, Fujii T, Shimoyama Y, Yamada S, Tanaka C, Kobayashi D, Koike M, Iwata N, Niwa Y, Hayashi M, Takami H, Nakayama G, Sugimoto H, Fujiwara M, Kodera Y

    Annals of surgical oncology   Vol. 23 ( 6 ) page: 1934-40   2016.6

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    DOI: 10.1245/s10434-016-5102-x

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  334. Adverse impact of low skeletal muscle index on the prognosis of hepatocellular carcinoma after hepatic resection.

    Yabusaki N, Fujii T, Yamada S, Suzuki K, Sugimoto H, Kanda M, Nakayama G, Koike M, Fujiwara M, Kodera Y

    International journal of surgery (London, England)   Vol. 30   page: 136-42   2016.6

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    DOI: 10.1016/j.ijsu.2016.04.049

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  335. Clinical Implication of Inflammation-Based Prognostic Score in Pancreatic Cancer: Glasgow Prognostic Score Is the Most Reliable Parameter.

    Yamada S, Fujii T, Yabusaki N, Murotani K, Iwata N, Kanda M, Tanaka C, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y

    Medicine   Vol. 95 ( 18 ) page: e3582   2016.5

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    DOI: 10.1097/MD.0000000000003582

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  336. Metastatic pathway-specific transcriptome analysis identifies MFSD4 as a putative tumor suppressor and biomarker for hepatic metastasis in patients with gastric cancer. Reviewed

    Kanda M, Shimizu D, Tanaka H, Shibata M, Iwata N, Hayashi M, Kobayashi D, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y

    Oncotarget   Vol. 7 ( 12 ) page: 13667-79   2016.3

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    DOI: 10.18632/oncotarget.7269

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  337. S-1 plus nab-paclitaxel is a promising regimen for pancreatic cancer in a preclinical model.

    Suenaga M, Yamada S, Fujii T, Tanaka C, Kanda M, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y

    Journal of surgical oncology   Vol. 113 ( 4 ) page: 413-9   2016.3

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    DOI: 10.1002/jso.24147

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  338. Comparison of the international consensus guidelines for predicting malignancy in intraductal papillary mucinous neoplasms.

    Yamada S, Fujii T, Murotani K, Kanda M, Sugimoto H, Nakayama G, Koike M, Fujiwara M, Nakao A, Kodera Y

    Surgery   Vol. 159 ( 3 ) page: 878-84   2016.3

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    DOI: 10.1016/j.surg.2015.08.042

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  339. NRAGE promotes the malignant phenotype of hepatocellular carcinoma.

    Shimizu D, Kanda M, Sugimoto H, Sueoka S, Takami H, Ezaka K, Tanaka Y, Hashimoto R, Okamura Y, Iwata N, Tanaka C, Yamada S, Fujii T, Nakayama G, Koike M, Nomoto S, Fujiwara M, Kodera Y

    Oncology letters   Vol. 11 ( 3 ) page: 1847-1854   2016.3

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    DOI: 10.3892/ol.2016.4120

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  340. Short-term outcomes after conventional transthoracic esophagectomy.

    Niwa Y, Koike M, Hattori M, Iwata N, Takami H, Hayashi M, Kanda M, Kobayashi D, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Nomoto S, Fujiwara M, Kodera Y

    Nagoya journal of medical science   Vol. 78 ( 1 ) page: 69-78   2016.2

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  341. Preoperative Identification of a Prognostic Factor for Pancreatic Neuroendocrine Tumors Using Multiphase Contrast-Enhanced Computed Tomography.

    Yamada S, Fujii T, Suzuki K, Inokawa Y, Kanda M, Nakayama G, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Nakao A, Kodera Y

    Pancreas   Vol. 45 ( 2 ) page: 198-203   2016.2

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    DOI: 10.1097/MPA.0000000000000443

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  342. Modified Blumgart Suturing Technique for Remnant Closure After Distal Pancreatectomy: a Propensity Score-Matched Analysis.

    Fujii T, Yamada S, Murotani K, Sugimoto H, Hattori M, Kanda M, Takami H, Nakayama G, Nomoto S, Fujiwara M, Nakao A, Kodera Y

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract   Vol. 20 ( 2 ) page: 374-84   2016.2

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    DOI: 10.1007/s11605-015-2980-3

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  343. The Prognostic Relevance of Subcarinal Lymph Node Dissection in Esophageal Squamous Cell Carcinoma.

    Niwa Y, Koike M, Hattori M, Iwata N, Takami H, Hayashi M, Tanaka C, Kobayashi D, Kanda M, Yamada S, Fujii T, Nakayama G, Sugimoto H, Fujiwara M, Kodera Y

    Annals of surgical oncology   Vol. 23 ( 2 ) page: 611-8   2016.2

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    DOI: 10.1245/s10434-015-4819-2

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  344. Adverse Effects of Intraoperative Blood Loss on Long-Term Outcomes after Curative Gastrectomy of Patients with Stage II/III Gastric Cancer.

    Mizuno A, Kanda M, Kobayashi D, Tanaka C, Iwata N, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y

    Digestive surgery   Vol. 33 ( 2 ) page: 121-8   2016

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    DOI: 10.1159/000443219

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  345. Oral Food Intake Versus Fasting on Postoperative Pancreatic Fistula After Distal Pancreatectomy: A Multi-Institutional Randomized Controlled Trial.

    Fujii T, Yamada S, Murotani K, Okamura Y, Ishigure K, Kanda M, Takeda S, Morita S, Nakao A, Kodera Y

    Medicine   Vol. 94 ( 52 ) page: e2398   2015.12

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    DOI: 10.1097/MD.0000000000002398

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  346. CD44 single nucleotide polymorphism and isoform switching may predict gastric cancer recurrence.

    Suenaga M, Yamada S, Fuchs BC, Fujii T, Kanda M, Tanaka C, Kobayashi D, Fujiwara M, Tanabe KK, Kodera Y

    Journal of surgical oncology   Vol. 112 ( 6 ) page: 622-8   2015.11

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    DOI: 10.1002/jso.24056

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  347. Effectiveness of plasma treatment on pancreatic cancer cells.

    Hattori N, Yamada S, Torii K, Takeda S, Nakamura K, Tanaka H, Kajiyama H, Kanda M, Fujii T, Nakayama G, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Mizuno M, Hori M, Kodera Y

    International journal of oncology   Vol. 47 ( 5 ) page: 1655-62   2015.11

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    DOI: 10.3892/ijo.2015.3149

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  348. Influence of Food Intake on the Healing Process of Postoperative Pancreatic Fistula After Pancreatoduodenectomy: A Multi-institutional Randomized Controlled Trial.

    Fujii T, Nakao A, Murotani K, Okamura Y, Ishigure K, Hatsuno T, Sakai M, Yamada S, Kanda M, Sugimoto H, Nomoto S, Takeda S, Morita S, Kodera Y

    Annals of surgical oncology   Vol. 22 ( 12 ) page: 3905-12   2015.11

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    DOI: 10.1245/s10434-015-4496-1

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  349. Capecitabine and oxaliplatin combined with bevacizumab are feasible for treating selected Japanese patients at least 75 years of age with metastatic colorectal cancer.

    Munemoto Y, Kanda M, Ishibashi K, Hata T, Kobayashi M, Hasegawa J, Fukunaga M, Takagane A, Otsuji T, Miyake Y, Nagase M, Sakamoto J, Matsuoka M, Oba K, Mishima H

    BMC cancer   Vol. 15   page: 786   2015.10

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    DOI: 10.1186/s12885-015-1712-0

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  350. Genetic and epigenetic aspects of initiation and progression of hepatocellular carcinoma. Reviewed

    Kanda M, Sugimoto H, Kodera Y

    World journal of gastroenterology   Vol. 21 ( 37 ) page: 10584-97   2015.10

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    DOI: 10.3748/wjg.v21.i37.10584

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  351. Updated evidence on adjuvant treatments for gastric cancer. Reviewed

    Kanda M, Kodera Y, Sakamoto J

    Expert review of gastroenterology & hepatology     page: 1-12   2015.9

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    DOI: 10.1586/17474124.2015.1094373

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  352. Adherens junctions associated protein 1 serves as a predictor of recurrence of squamous cell carcinoma of the esophagus. Reviewed

    Tanaka H, Kanda M, Koike M, Iwata N, Shimizu D, Ezaka K, Sueoka S, Tanaka Y, Takami H, Hashimoto R, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Fujiwara M, Kodera Y

    International journal of oncology     2015.9

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    DOI: 10.3892/ijo.2015.3167

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  353. Recent advances in the molecular diagnostics of gastric cancer. Reviewed

    Kanda M, Kodera Y

    World journal of gastroenterology : WJG   Vol. 21 ( 34 ) page: 9838-52   2015.9

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    DOI: 10.3748/wjg.v21.i34.9838

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  354. Inverse Probability of Treatment Weighting Analysis of Upfront Surgery Versus Neoadjuvant Chemoradiotherapy Followed by Surgery for Pancreatic Adenocarcinoma with Arterial Abutment.

    Fujii T, Yamada S, Murotani K, Kanda M, Sugimoto H, Nakao A, Kodera Y

    Medicine   Vol. 94 ( 39 ) page: e1647   2015.9

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    DOI: 10.1097/MD.0000000000001647

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  355. Factors related to occurrence and aggravation of pancreatic fistula after radical gastrectomy for gastric cancer.

    Kobayashi D, Iwata N, Tanaka C, Kanda M, Yamada S, Nakayama G, Fujii T, Koike M, Fujiwara M, Kodera Y

    Journal of surgical oncology   Vol. 112 ( 4 ) page: 381-6   2015.9

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    DOI: 10.1002/jso.24001

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  356. Function and diagnostic value of Anosmin-1 in gastric cancer progression. Reviewed

    Kanda M, Shimizu D, Fujii T, Sueoka S, Tanaka Y, Ezaka K, Takami H, Tanaka H, Hashimoto R, Iwata N, Kobayashi D, Tanaka C, Yamada S, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y

    International journal of cancer. Journal international du cancer     2015.8

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    DOI: 10.1002/ijc.29803

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  357. Excess Weight Adversely Influences Treatment Length of Postoperative Pancreatic Fistula: A Retrospective Study of 900 Patients.

    Fujii T, Kanda M, Nagai S, Suenaga M, Takami H, Yamada S, Sugimoto H, Nomoto S, Nakao A, Kodera Y

    Pancreas   Vol. 44 ( 6 ) page: 971-6   2015.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MPA.0000000000000352

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  358. Effectiveness of plasma treatment on gastric cancer cells.

    Torii K, Yamada S, Nakamura K, Tanaka H, Kajiyama H, Tanahashi K, Iwata N, Kanda M, Kobayashi D, Tanaka C, Fujii T, Nakayama G, Koike M, Sugimoto H, Nomoto S, Natsume A, Fujiwara M, Mizuno M, Hori M, Saya H, Kodera Y

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   Vol. 18 ( 3 ) page: 635-43   2015.7

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    DOI: 10.1007/s10120-014-0395-6

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  359. Reduced Expression of Adherens Junctions Associated Protein 1 Predicts Recurrence of Hepatocellular Carcinoma After Curative Hepatectomy. Reviewed

    Ezaka K, Kanda M, Sugimoto H, Shimizu D, Oya H, Nomoto S, Sueoka S, Tanaka Y, Takami H, Hashimoto R, Okamura Y, Yamada S, Fujii T, Nakayama G, Koike M, Fujiwara M, Kodera Y

    Annals of surgical oncology     2015.6

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    DOI: 10.1245/s10434-015-4695-9

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  360. Postoperative adjuvant chemotherapy with S-1 alters recurrence patterns and prognostic factors among patients with stage II/III gastric cancer: A propensity score matching analysis. Reviewed

    Kanda M, Murotani K, Kobayashi D, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y

    Surgery     2015.6

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    DOI: 10.1016/j.surg.2015.05.017

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  361. Translational implication of Kallmann syndrome-1 gene expression in hepatocellular carcinoma. Reviewed

    Tanaka Y, Kanda M, Sugimoto H, Shimizu D, Sueoka S, Takami H, Ezaka K, Hashimoto R, Okamura Y, Iwata N, Tanaka C, Yamada S, Fujii T, Nakayama G, Koike M, Nomoto S, Fujiwara M, Kodera Y

    International journal of oncology   Vol. 46 ( 6 ) page: 2546-54   2015.6

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    DOI: 10.3892/ijo.2015.2965

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  362. Protein tyrosine kinase 7: a hepatocellular carcinoma-related gene detected by triple-combination array.

    Hishida M, Inokawa Y, Takano N, Nishikawa Y, Iwata N, Kanda M, Tanaka C, Kobayashi D, Yamada S, Nakayama G, Fujii T, Sugimoto H, Koike M, Fujiwara M, Kodera Y, Nomoto S

    The Journal of surgical research   Vol. 195 ( 2 ) page: 444-53   2015.5

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    DOI: 10.1016/j.jss.2014.12.045

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  363. Diversity of clinical implication of B-cell translocation gene 1 expression by histopathologic and anatomic subtypes of gastric cancer. Reviewed

    Kanda M, Oya H, Nomoto S, Takami H, Shimizu D, Hashimoto R, Sueoka S, Kobayashi D, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y

    Digestive diseases and sciences   Vol. 60 ( 5 ) page: 1256-64   2015.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10620-014-3477-8

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  364. Dihydropyrimidinase-like 3 is a putative hepatocellular carcinoma tumor suppressor. Reviewed

    Oya H, Kanda M, Sugimoto H, Shimizu D, Takami H, Hibino S, Hashimoto R, Okamura Y, Yamada S, Fujii T, Nakayama G, Koike M, Nomoto S, Fujiwara M, Kodera Y

    Journal of gastroenterology   Vol. 50 ( 5 ) page: 590-600   2015.5

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    DOI: 10.1007/s00535-014-0993-4

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  365. KRAS and guanine nucleotide-binding protein mutations in pancreatic juice collected from the duodenum of patients at high risk for neoplasia undergoing endoscopic ultrasound. Reviewed

    Eshleman JR, Norris AL, Sadakari Y, Debeljak M, Borges M, Harrington C, Lin E, Brant A, Barkley T, Almario JA, Topazian M, Farrell J, Syngal S, Lee JH, Yu J, Hruban RH, Kanda M, Canto MI, Goggins M

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association   Vol. 13 ( 5 ) page: 963-9.e4   2015.5

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    DOI: 10.1016/j.cgh.2014.11.028

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  366. A vascular endothelial growth factor gene polymorphism predicts malignant potential in intraductal papillary mucinous neoplasm.

    Yabusaki N, Yamada S, Shimoyama Y, Fujii T, Kanda M, Nakayama G, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Nakao A, Kodera Y

    Pancreas   Vol. 44 ( 4 ) page: 608-14   2015.5

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    DOI: 10.1097/MPA.0000000000000305

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  367. Feeding duodenostomy decreases the incidence of mechanical obstruction after radical esophageal cancer surgery.

    Oya H, Koike M, Iwata N, Kobayashi D, Torii K, Niwa Y, Kanda M, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Nomoto S, Fujiwara M, Kodera Y

    World journal of surgery   Vol. 39 ( 5 ) page: 1105-10   2015.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00268-015-2952-5

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  368. CCNJ detected by triple combination array analysis as a tumor-related gene of hepatocellular carcinoma.

    Takano N, Hishida M, Inokawa Y, Hayashi M, Kanda M, Nishikawa Y, Iwata N, Kobayashi D, Tanaka C, Yamada S, Nakayama G, Fujii T, Sugimoto H, Koike M, Fujiwara M, Kodera Y, Nomoto S

    International journal of oncology   Vol. 46 ( 5 ) page: 1963-70   2015.5

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    DOI: 10.3892/ijo.2015.2892

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  369. SMAD4 expression predicts local spread and treatment failure in resected pancreatic cancer.

    Yamada S, Fujii T, Shimoyama Y, Kanda M, Nakayama G, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Nakao A, Kodera Y

    Pancreas   Vol. 44 ( 4 ) page: 660-4   2015.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MPA.0000000000000315

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  370. Prognostic impact of expression and methylation status of DENN/MADD domain-containing protein 2D in gastric cancer. Reviewed

    Kanda M, Shimizu D, Nomoto S, Takami H, Hibino S, Oya H, Hashimoto R, Suenaga M, Inokawa Y, Kobayashi D, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y

    Gastric cancer   Vol. 18 ( 2 ) page: 288-96   2015.4

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    DOI: 10.1007/s10120-014-0372-0

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  371. Vein resections &gt;3 cm during pancreatectomy are associated with poor 1-year patency rates.

    Fujii T, Nakao A, Yamada S, Suenaga M, Hattori M, Takami H, Inokawa Y, Kanda M, Sugimoto H, Nomoto S, Murotani K, Kodera Y

    Surgery   Vol. 157 ( 4 ) page: 708-15   2015.4

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    DOI: 10.1016/j.surg.2014.12.002

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  372. Preoperative internal biliary drainage increases the risk of bile juice infection and pancreatic fistula after pancreatoduodenectomy: a prospective observational study.

    Fujii T, Yamada S, Suenaga M, Kanda M, Takami H, Sugimoto H, Nomoto S, Nakao A, Kodera Y

    Pancreas   Vol. 44 ( 3 ) page: 465-70   2015.4

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    DOI: 10.1097/MPA.0000000000000265

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  373. Suppression of SAMSN1 Expression is Associated with the Malignant Phenotype of Hepatocellular Carcinoma. Reviewed

    Sueoka S, Kanda M, Sugimoto H, Shimizu D, Nomoto S, Oya H, Takami H, Ezaka K, Hashimoto R, Tanaka Y, Okamura Y, Yamada S, Fujii T, Nakayama G, Koike M, Fujiwara M, Kodera Y

    Annals of surgical oncology     2015.3

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    DOI: 10.1245/s10434-015-4524-1

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  374. The Expression of Melanoma-Associated Antigen D2 Both in Surgically Resected and Serum Samples Serves as Clinically Relevant Biomarker of Gastric Cancer Progression. Reviewed

    Kanda M, Nomoto S, Oya H, Takami H, Shimizu D, Hibino S, Hashimoto R, Kobayashi D, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y

    Annals of surgical oncology     2015.3

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    DOI: 10.1245/s10434-015-4457-8

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  375. Aberrant expression of melanoma-associated antigen-D2 serves as a prognostic indicator of hepatocellular carcinoma outcome following curative hepatectomy. Reviewed

    Hashimoto R, Kanda M, Takami H, Shimizu D, Oya H, Hibino S, Okamura Y, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Kodera Y

    Oncology letters   Vol. 9 ( 3 ) page: 1201-1206   2015.3

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    DOI: 10.3892/ol.2014.2823

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  376. Clinical significance of zinc-finger E-box binding homeobox 1 mRNA levels in peritoneal washing for gastric cancer.

    Yabusaki N, Yamada S, Murai T, Kanda M, Kobayashi D, Tanaka C, Fujii T, Nakayama G, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Kodera Y

    Molecular and clinical oncology   Vol. 3 ( 2 ) page: 435-441   2015.3

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    DOI: 10.3892/mco.2014.462

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  377. Method of bilateral pleural drainage by single Blake drain after esophagectomy.

    Niwa Y, Koike M, Oya H, Iwata N, Kobayashi D, Kanda M, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Nomoto S, Fujiwara M, Kodera Y

    World journal of surgery   Vol. 39 ( 3 ) page: 727-31   2015.3

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    DOI: 10.1007/s00268-014-2860-0

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  378. Serosal invasion strongly associated with recurrence after curative hepatic resection of hepatocellular carcinoma: a retrospective study of 214 consecutive cases.

    Sonohara F, Nomoto S, Inokawa Y, Kanda M, Yamada S, Fujii T, Sugimoto H, Kodera Y

    Medicine   Vol. 94 ( 9 ) page: e602   2015.3

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    DOI: 10.1097/MD.0000000000000602

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  379. B‑cell translocation gene 1 serves as a novel prognostic indicator of hepatocellular carcinoma. Reviewed

      Vol. 46 ( 2 ) page: 641-8   2015.2

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    DOI: 10.3892/ijo.2014.2762

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  380. High expression of Janus kinase 2 in background normal liver tissue of resected hepatocellular carcinoma is associated with worse prognosis.

    Sonohara F, Nomoto S, Inokawa Y, Hishida M, Takano N, Kanda M, Nishikawa Y, Fujii T, Koike M, Sugimoto H, Kodera Y

    Oncology reports   Vol. 33 ( 2 ) page: 767-73   2015.2

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    DOI: 10.3892/or.2014.3621

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  381. Adverse prognostic impact of perioperative allogeneic transfusion on patients with stage II/III gastric cancer. Reviewed

    Kanda M, Kobayashi D, Tanaka C, Iwata N, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Nomoto S, Murotani K, Fujiwara M, Kodera Y

    Gastric cancer     2015.1

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    DOI: 10.1007/s10120-014-0456-x

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  382. Significance of the Splenic Vein and Its Branches in Pancreatoduodenectomy with Resection of the Portal Vein System.

    Hattori M, Fujii T, Yamada S, Inokawa Y, Suenaga M, Takami H, Kanda M, Sugimoto H, Nomoto S, Murotani K, Nakao A, Kodera Y

    Digestive surgery   Vol. 32 ( 5 ) page: 382-8   2015

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    DOI: 10.1159/000438797

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  383. Mutant KRAS and GNAS DNA Concentrations in Secretin-Stimulated Pancreatic Fluid Collected from the Pancreatic Duct and the Duodenal Lumen. Reviewed

    Sadakari Y, Kanda M, Maitani K, Borges M, Canto MI, Goggins M

    Clinical and translational gastroenterology   Vol. 5   page: e62   2014.11

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    DOI: 10.1038/ctg.2014.14

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  384. Clinical utility of PDSS2 expression to stratify patients at risk for recurrence of hepatocellular carcinoma. Reviewed

    Kanda M, Sugimoto H, Nomoto S, Oya H, Shimizu D, Takami H, Hashimoto R, Sonohara F, Okamura Y, Yamada S, Fujii T, Nakayama G, Koike M, Fujiwara M, Kodera Y

    International journal of oncology   Vol. 45 ( 5 ) page: 2005-12   2014.11

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    DOI: 10.3892/ijo.2014.2637

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  385. Hepatectomy for hepatocellular carcinoma in patients with hemophilia.

    Inokawa Y, Sugimoto H, Kanda M, Yamada S, Fujii T, Nomoto S, Takeda S, Suzuki N, Matsushita T, Kodera Y

    Journal of hepato-biliary-pancreatic sciences   Vol. 21 ( 11 ) page: 824-8   2014.11

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    DOI: 10.1002/jhbp.142

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  386. Epithelial to mesenchymal transition correlates with tumor budding and predicts prognosis in esophageal squamous cell carcinoma.

    Niwa Y, Yamada S, Koike M, Kanda M, Fujii T, Nakayama G, Sugimoto H, Nomoto S, Fujiwara M, Kodera Y

    Journal of surgical oncology   Vol. 110 ( 6 ) page: 764-9   2014.11

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    DOI: 10.1002/jso.23694

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  387. Epithelial to mesenchymal transition might be induced via CD44 isoform switching in colorectal cancer.

    Mashita N, Yamada S, Nakayama G, Tanaka C, Iwata N, Kanda M, Kobayashi D, Fujii T, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Kodera Y

    Journal of surgical oncology   Vol. 110 ( 6 ) page: 745-51   2014.11

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    DOI: 10.1002/jso.23705

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  388. Decreased expression of prenyl diphosphate synthase subunit 2 correlates with reduced survival of patients with gastric cancer. Reviewed

    Kanda M, Nomoto S, Oya H, Hashimoto R, Takami H, Shimizu D, Sonohara F, Kobayashi D, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Murotani K, Fujiwara M, Kodera Y

    Journal of experimental & clinical cancer research : CR   Vol. 33   page: 88   2014.10

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    DOI: 10.1186/s13046-014-0088-3

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  389. Estimated pancreatic parenchymal remnant volume accurately predicts clinically relevant pancreatic fistula after pancreatoduodenectomy. Reviewed

    Kanda M, Fujii T, Suenaga M, Takami H, Hattori M, Inokawa Y, Yamada S, Nakayama G, Sugimoto H, Koike M, Nomoto S, Kodera Y.

    Surgery   Vol. 156 ( 3 ) page: 601-610   2014.9

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  390. The combination of the serum carbohydrate antigen 19-9 and carcinoembryonic antigen is a simple and accurate predictor of mortality in pancreatic cancer patients. Reviewed

    Kanda M, Fujii T, Takami H, Suenaga M, Inokawa Y, Yamada S, Nakayama G, Sugimoto H, Koike M, Nomoto S, Kodera Y.

    Surgery Today   Vol. 44 ( 9 ) page: 1692-701   2014.9

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  391. Estimated pancreatic parenchymal remnant volume accurately predicts clinically relevant pancreatic fistula after pancreatoduodenectomy. Reviewed

    Kanda M, Fujii T, Suenaga M, Takami H, Hattori M, Inokawa Y, Yamada S, Nakayama G, Sugimoto H, Koike M, Nomoto S, Kodera Y

    Surgery   Vol. 156 ( 3 ) page: 601-10   2014.9

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    DOI: 10.1016/j.surg.2014.04.011

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  392. Combination of the serum carbohydrate antigen 19-9 and carcinoembryonic antigen is a simple and accurate predictor of mortality in pancreatic cancer patients. Reviewed

    Kanda M, Fujii T, Takami H, Suenaga M, Inokawa Y, Yamada S, Nakayama G, Sugimoto H, Koike M, Nomoto S, Kodera Y

    Surgery today   Vol. 44 ( 9 ) page: 1692-701   2014.9

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    DOI: 10.1007/s00595-013-0752-9

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  393. Pattern of first recurrent lesions in pancreatic cancer: hepatic relapse is associated with dismal prognosis and portal vein invasion.

    Suenaga M, Fujii T, Kanda M, Takami H, Okumura N, Inokawa Y, Kobayashi D, Tanaka C, Yamada S, Sugimoto H, Nomoto S, Fujiwara M, Kodera Y

    Hepato-gastroenterology   Vol. 61 ( 134 ) page: 1756-61   2014.9

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  394. Comparison of inflammation-based prognostic scores as predictors of tumor recurrence in patients with hepatocellular carcinoma after curative resection.

    Yamamura K, Sugimoto H, Kanda M, Yamada S, Nomoto S, Nakayama G, Fujii T, Koike M, Fujiwara M, Kodera Y

    Journal of hepato-biliary-pancreatic sciences   Vol. 21 ( 9 ) page: 682-8   2014.9

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    DOI: 10.1002/jhbp.114

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  395. Dihydropyrimidinase-like 3 facilitates malignant behavior of gastric cancer. Reviewed

    Kanda M, Nomoto S, Oya H, Shimizu D, Takami H, Hibino S, Hashimoto R, Kobayashi D, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y

    Journal of experimental & clinical cancer research : CR   Vol. 33   page: 66   2014.8

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    DOI: 10.1186/s13046-014-0066-9

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  396. Pancreatoduodenectomy with portal vein resection is feasible and potentially beneficial for elderly patients with pancreatic cancer. Reviewed

    Kanda M, Fujii T, Suenaga M, Takami H, Inokawa Y, Yamada S, Kobayashi D, Tanaka C, Sugimoto H, Nomoto S, Fujiwara M, Kodera Y.

    Pancreas   Vol. 43 ( 6 ) page: 951-958   2014.8

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  397. Clinical significance of expression and epigenetic profiling of TUSC1 in gastric cancer. Reviewed

    Kanda M, Shimizu D, Nomoto S, Hibino S, Oya H, Takami H, Kobayashi D, Yamada S, Inokawa Y, Tanaka C, Fujii T, Sugimoto H, Koike M, Fujiwara M, Kodera Y.

    Journal of Surgical Oncology   Vol. 110 ( 2 ) page: 136-144   2014.8

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  398. ovel diagnostics for aggravating pancreatic fistulas at the acute phase after pancreatectomy. Reviewed

    Kanda M, Fujii T, Takami H, Suenaga M, Inokawa Y, Yamada S, Kobayashi D, Tanaka C, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Kodera Y.

    World Journal of Gastroenterology   Vol. 20 ( 26 ) page: 8535-8544   2014.7

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  399. Novel diagnostics for aggravating pancreatic fistulas at the acute phase after pancreatectomy. Reviewed

    Kanda M, Fujii T, Takami H, Suenaga M, Inokawa Y, Yamada S, Kobayashi D, Tanaka C, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Kodera Y

    World journal of gastroenterology : WJG   Vol. 20 ( 26 ) page: 8535-44   2014.7

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    DOI: 10.3748/wjg.v20.i26.8535

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  400. Clinical implication of morphological subtypes in management of intraductal papillary mucinous neoplasm.

    Yamada S, Fujii T, Shimoyama Y, Kanda M, Nakayama G, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Nakao A, Kodera Y

    Annals of surgical oncology   Vol. 21 ( 7 ) page: 2444-52   2014.7

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    DOI: 10.1245/s10434-014-3565-1

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  401. Preservation of the pyloric ring confers little benefit in patients undergoing total pancreatectomy.

    Takami H, Fujii T, Kanda M, Suenaga M, Yamamura K, Kodera Y

    World journal of surgery   Vol. 38 ( 7 ) page: 1807-13   2014.7

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    DOI: 10.1007/s00268-014-2469-3

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  402. Modified Blumgart anastomosis for pancreaticojejunostomy: technical improvement in matched historical control study.

    Fujii T, Sugimoto H, Yamada S, Kanda M, Suenaga M, Takami H, Hattori M, Inokawa Y, Nomoto S, Fujiwara M, Kodera Y

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract   Vol. 18 ( 6 ) page: 1108-15   2014.6

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    DOI: 10.1007/s11605-014-2523-3

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  403. Expression analysis of THOP1 in background liver, a prognostic predictive factor in hepatocellular carcinoma, extracted by multiarray analysis.

    Nomoto S, Hishida M, Inokawa Y, Takano N, Kanda M, Nishikawa Y, Fujii T, Koike M, Sugimoto H, Kodera Y

    Annals of surgical oncology   Vol. 21 Suppl 3   page: S443-50   2014.6

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    DOI: 10.1245/s10434-014-3581-1

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  404. Prognostic impact of expression and methylation status of DENN/MADD domain-containing protein 2D in gastric cancer. Gastric Cancer. Reviewed

    Kanda M, Shimizu D, Nomoto S, Takami H, Hibino S, Oya H, Hashimoto R, Suenaga M, Inokawa Y, Kobayashi D, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y.

    Gastric Cancer     page: [Epub ahead of print]   2014.4

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  405. The impact of dose/time modification in irinotecan- and oxaliplatin-based chemotherapies on outcomes in metastatic colorectal cancer.

    Nakayama G, Tanaka C, Uehara K, Mashita N, Hayashi N, Kobayashi D, Kanda M, Yamada S, Fujii T, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Ando Y, Kodera Y

    Cancer chemotherapy and pharmacology   Vol. 73 ( 4 ) page: 847-55   2014.4

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    DOI: 10.1007/s00280-014-2416-x

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  406. Identification of intragenic methylation in the TUSC1 gene as a novel prognostic marker of hepatocellular carcinoma. Reviewed

    Shimizu D, Kanda M, Nomoto S, Oya H, Takami H, Hibino S, Suenaga M, Inokawa Y, Hishida M, Takano N, Nishikawa Y, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y

    Oncology reports   Vol. 31 ( 3 ) page: 1305-13   2014.3

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    DOI: 10.3892/or.2013.2939

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  407. Identification of the collagen type 1 α 1 gene (COL1A1) as a candidate survival-related factor associated with hepatocellular carcinoma.

      Vol. 14   page: 108   2014.2

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    DOI: 10.1186/1471-2407-14-108

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  408. Reduced expression of DENND2D through promoter hypermethylation is an adverse prognostic factor in squamous cell carcinoma of the esophagus. Reviewed

    Hibino S, Kanda M, Oya H, Takami H, Shimizu D, Nomoto S, Hishida M, Niwa Y, Koike M, Yamada S, Nishikawa Y, Asai M, Nakayama G, Fujii T, Sugimoto H, Fujiwara M, Kodera Y

    Oncology reports   Vol. 31 ( 2 ) page: 693-700   2014.2

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    DOI: 10.3892/or.2013.2901

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  409. Combination treatment of human pancreatic cancer xenograft models with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib and oncolytic herpes simplex virus HF10.

    Yamamura K, Kasuya H, Sahin TT, Tan G, Hotta Y, Tsurumaru N, Fukuda S, Kanda M, Kobayashi D, Tanaka C, Yamada S, Nakayama G, Fujii T, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Tanaka M, Kodera Y

    Annals of surgical oncology   Vol. 21 ( 2 ) page: 691-8   2014.2

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    DOI: 10.1245/s10434-013-3329-3

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  410. Downregulation of DENND2D by promoter hypermethylation is associated with early recurrence of hepatocellular carcinoma. Reviewed

    Kanda M, Nomoto S, Oya H, Takami H, Hibino S, Hishida M, Suenaga M, Yamada S, Inokawa Y, Nishikawa Y, Asai M, Fujii T, Sugimoto H, Kodera Y

    International journal of oncology   Vol. 44 ( 1 ) page: 44-52   2014.1

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    DOI: 10.3892/ijo.2013.2165

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  411. B-cell translocation gene 1 serves as a novel prognostic indicator of hepatocellular carcinoma. Reviewed

    Kanda M, Sugimoto H, Nomoto S, Oya H, Hibino S, Shimizu D, Takami H, Hashimoto R, Okamura Y, Yamada S, Fujii T, Nakayama G, Koike M, Fujiwara M, Kodera Y.

    International Journal of Oncology     page: (in press)   2014

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  412. A functional polymorphism in the epidermal growth factor gene predicts hepatocellular carcinoma risk in Japanese hepatitis C patients.

    Suenaga M, Yamada S, Fujii T, Fuchs BC, Okumura N, Kanda M, Kobayashi D, Tanaka C, Nakayama G, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Takeda S, Hayashi K, Tanabe KK, Goto H, Kodera Y

    OncoTargets and therapy   Vol. 6   page: 1805-12   2013.12

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    DOI: 10.2147/OTT.S53625

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  413. Evaluation of MAGE-D4 expression in hepatocellular carcinoma in Japanese patients. Reviewed

    Takami H, Kanda M, Oya H, Hibino S, Sugimoto H, Suenaga M, Yamada S, Nishikawa Y, Asai M, Fujii T, Nomoto S, Kodera Y

    Journal of surgical oncology   Vol. 108 ( 8 ) page: 557-62   2013.12

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    DOI: 10.1002/jso.23440

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  414. [Recurrent acute pancreatitis due to arteriovenous malformation of the pancreas].

    Suenaga M, Fujii T, Kanda M, Yamada S, Okumura N, Takeda S, Kodera Y

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   Vol. 110 ( 11 ) page: 1983-8   2013.11

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  415. Dynamin 3: a new candidate tumor suppressor gene in hepatocellular carcinoma detected by triple combination array analysis.

    Inokawa Y, Nomoto S, Hishida M, Hayashi M, Kanda M, Nishikawa Y, Takeda S, Fujiwara M, Koike M, Sugimoto H, Fujii T, Nakayama G, Yamada S, Tanaka C, Kobayashi D, Kodera Y

    OncoTargets and therapy   Vol. 6   page: 1417-24   2013.10

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    DOI: 10.2147/OTT.S51913

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  416. Detection of doublecortin domain-containing 2 (DCDC2), a new candidate tumor suppressor gene of hepatocellular carcinoma, by triple combination array analysis.

    Inokawa Y, Nomoto S, Hishida M, Hayashi M, Kanda M, Nishikawa Y, Takeda S, Sugimoto H, Fujii T, Yamada S, Kodera Y

    Journal of experimental & clinical cancer research : CR   Vol. 32   page: 65   2013.9

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    DOI: 10.1186/1756-9966-32-65

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  417. Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts. Reviewed

    Kanda M, Knight S, Topazian M, Syngal S, Farrell J, Lee J, Kamel I, Lennon AM, Borges M, Young A, Fujiwara S, Seike J, Eshleman J, Hruban RH, Canto MI, Goggins M

    Gut   Vol. 62 ( 7 ) page: 1024-33   2013.7

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    DOI: 10.1136/gutjnl-2012-302823

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  418. Estrogen receptor 1 gene as a tumor suppressor gene in hepatocellular carcinoma detected by triple-combination array analysis.

    Hishida M, Nomoto S, Inokawa Y, Hayashi M, Kanda M, Okamura Y, Nishikawa Y, Tanaka C, Kobayashi D, Yamada S, Nakayama G, Fujii T, Sugimoto H, Koike M, Fujiwara M, Takeda S, Kodera Y

    International journal of oncology   Vol. 43 ( 1 ) page: 88-94   2013.7

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    DOI: 10.3892/ijo.2013.1951

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  419. Mutant TP53 in duodenal samples of pancreatic juice from patients with pancreatic cancer or high-grade dysplasia. Reviewed

    Kanda M, Sadakari Y, Borges M, Topazian M, Farrell J, Syngal S, Lee J, Kamel I, Lennon AM, Knight S, Fujiwara S, Hruban RH, Canto MI, Goggins M

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association   Vol. 11 ( 6 ) page: 719-30.e5   2013.6

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    DOI: 10.1016/j.cgh.2012.11.016

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  420. Genome-wide somatic copy number alterations in low-grade PanINs and IPMNs from individuals with a family history of pancreatic cancer. Reviewed

    Hong SM, Vincent A, Kanda M, Leclerc J, Omura N, Borges M, Klein AP, Canto MI, Hruban RH, Goggins M

    Clinical cancer research : an official journal of the American Association for Cancer Research   Vol. 18 ( 16 ) page: 4303-12   2012.8

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    DOI: 10.1158/1078-0432.CCR-12-1075

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  421. Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia. Reviewed

    Kanda M, Matthaei H, Wu J, Hong SM, Yu J, Borges M, Hruban RH, Maitra A, Kinzler K, Vogelstein B, Goggins M

    Gastroenterology   Vol. 142 ( 4 ) page: 730-733.e9   2012.4

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    DOI: 10.1053/j.gastro.2011.12.042

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  422. Preservation of the pyloric ring has little value in surgery for pancreatic head cancer: a comparative study comparing three surgical procedures.

    Fujii T, Kanda M, Kodera Y, Nagai S, Sahin TT, Hayashi M, Kanzaki A, Yamada S, Sugimoto H, Nomoto S, Takeda S, Morita S, Nakao A

    Annals of surgical oncology   Vol. 19 ( 1 ) page: 176-83   2012.1

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    DOI: 10.1245/s10434-011-1901-2

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  423. Comparison of pancreatic head resection with segmental duodenectomy and pylorus-preserving pancreatoduodenectomy for benign and low-grade malignant neoplasms of the pancreatic head.

    Fujii T, Kanda M, Kodera Y, Nagai S, Sahin TT, Kanzaki A, Yamada S, Sugimoto H, Nomoto S, Morita S, Takeda S, Nakao A

    Pancreas   Vol. 40 ( 8 ) page: 1258-63   2011.11

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    DOI: 10.1097/MPA.0b013e318220b1c0

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  424. Prognostic implications of lymph node metastases in carcinoma of the body and tail of the pancreas.

    Sahin TT, Fujii T, Kanda M, Nagai S, Kodera Y, Kanzaki A, Yamamura K, Sugimoto H, Kasuya H, Nomoto S, Takeda S, Morita S, Nakao A

    Pancreas   Vol. 40 ( 7 ) page: 1029-33   2011.10

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    DOI: 10.1097/MPA.0b013e3182207893

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  425. Pattern of lymph node metastasis spread in pancreatic cancer. Reviewed

    Kanda M, Fujii T, Nagai S, Kodera Y, Kanzaki A, Sahin TT, Hayashi M, Yamada S, Sugimoto H, Nomoto S, Takeda S, Morita S, Nakao A

    Pancreas   Vol. 40 ( 6 ) page: 951-5   2011.8

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    DOI: 10.1097/MPA.0b013e3182148342

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  426. Promoter hypermethylation of fibulin 1 gene is associated with tumor progression in hepatocellular carcinoma. Reviewed

    Kanda M, Nomoto S, Okamura Y, Hayashi M, Hishida M, Fujii T, Nishikawa Y, Sugimoto H, Takeda S, Nakao A

    Molecular carcinogenesis   Vol. 50 ( 8 ) page: 571-9   2011.8

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    DOI: 10.1002/mc.20735

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  427. Recurrence pattern and prognosis of pancreatic cancer after pancreatic fistula.

    Nagai S, Fujii T, Kodera Y, Kanda M, Sahin TT, Kanzaki A, Hayashi M, Sugimoto H, Nomoto S, Takeda S, Morita S, Nakao A

    Annals of surgical oncology   Vol. 18 ( 8 ) page: 2329-37   2011.8

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    DOI: 10.1245/s10434-011-1604-8

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  428. Nutritional predictors of postoperative outcome in pancreatic cancer. Reviewed

    Kanda M, Fujii T, Kodera Y, Nagai S, Takeda S, Nakao A.

    British Journal of Surgery   Vol. 98 ( 2 ) page: 268-274   2011.2

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  429. Reduced expression of reelin (RELN) gene is associated with high recurrence rate of hepatocellular carcinoma.

    Okamura Y, Nomoto S, Kanda M, Hayashi M, Nishikawa Y, Fujii T, Sugimoto H, Takeda S, Nakao A

    Annals of surgical oncology   Vol. 18 ( 2 ) page: 572-9   2011.2

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    DOI: 10.1245/s10434-010-1273-z

    PubMed

  430. Impact of operative blood loss on survival in invasive ductal adenocarcinoma of the pancreas.

    Nagai S, Fujii T, Kodera Y, Kanda M, Sahin TT, Kanzaki A, Yamada S, Sugimoto H, Nomoto S, Takeda S, Morita S, Nakao A

    Pancreas   Vol. 40 ( 1 ) page: 3-9   2011.1

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    DOI: 10.1097/MPA.0b013e3181f7147a

    PubMed

  431. Prognostic implications of intraoperative radiotherapy for unresectable pancreatic cancer.

    Nagai S, Fujii T, Kodera Y, Kanda M, Sahin TT, Kanzaki A, Yamada S, Sugimoto H, Nomoto S, Takeda S, Morita S, Nakao A

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]   Vol. 11 ( 1 ) page: 68-75   2011

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000324682

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  432. Prognostic impact of pancreatic margin status in the intraductal papillary mucinous neoplasms of the pancreas.

    Fujii T, Kato K, Kodera Y, Kanda M, Nagai S, Yamada S, Kanzaki A, Sugimoto H, Nomoto S, Takeda S, Morita S, Nakamura S, Nakao A

    Surgery   Vol. 148 ( 2 ) page: 285-90   2010.8

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    DOI: 10.1016/j.surg.2010.03.013

    PubMed

  433. Leukemia inhibitory factor receptor (LIFR) is detected as a novel suppressor gene of hepatocellular carcinoma using double-combination array.

    Okamura Y, Nomoto S, Kanda M, Li Q, Nishikawa Y, Sugimoto H, Kanazumi N, Takeda S, Nakao A

    Cancer letters   Vol. 289 ( 2 ) page: 170-7   2010.3

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    DOI: 10.1016/j.canlet.2009.08.013

    PubMed

  434. Operative treatment of pancreatic ductal adenocarcinoma with extensive portal venous tumor embolism. Reviewed

    Kanda M, Takeda S, Yamada S, Fujii T, Sugimoto H, Kanazumi N, Nomoto S, Nakao A.

    Pancreas   Vol. 39 ( 2 ) page: 268-269   2010.3

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  435. Operative treatment of thrombotic occlusion of the portal vein immediately after pancreatectomy with portal vein resection. Reviewed

    Kanda M, Takeda S, Yamada S, Fujii T, Sugimoto H, Kanazumi N, Nomoto S, Nakao A.

    Pancreas   Vol. 39 ( 2 ) page: 265-266   2010.3

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  436. Operative treatment of thrombotic occlusion of the portal vein immediately after pancreatectomy with portal vein resection. Reviewed

    Kanda M, Takeda S, Yamada S, Fujii T, Sugimoto H, Kanazumi N, Nomoto S, Nakao A

    Pancreas   Vol. 39 ( 2 ) page: 265-6   2010.3

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    DOI: 10.1097/MPA.0b013e3181baef66

    PubMed

  437. Invasion of the splenic artery is a crucial prognostic factor in carcinoma of the body and tail of the pancreas. Reviewed

    Kanda M, Fujii T, Sahin TT, Kanzaki A, Nagai S, Yamada S, Sugimoto H, Nomoto S, Takeda S, Kodera Y, Morita S, Nakao A

    Annals of surgery   Vol. 251 ( 3 ) page: 483-7   2010.3

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    DOI: 10.1097/SLA.0b013e3181cf9171

    PubMed

  438. Epidermal growth factor-containing fibulin-like extracellular matrix protein 1, EFEMP1, a novel tumor-suppressor gene detected in hepatocellular carcinoma using double combination array analysis.

    Nomoto S, Kanda M, Okamura Y, Nishikawa Y, Qiyong L, Fujii T, Sugimoto H, Takeda S, Nakao A

    Annals of surgical oncology   Vol. 17 ( 3 ) page: 923-32   2010.3

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    DOI: 10.1245/s10434-009-0790-0

    PubMed

  439. Detection of metallothionein 1G as a methylated tumor suppressor gene in human hepatocellular carcinoma using a novel method of double combination array analysis. Reviewed

    Kanda M, Nomoto S, Okamura Y, Nishikawa Y, Sugimoto H, Kanazumi N, Takeda S, Nakao A

    International journal of oncology   Vol. 35 ( 3 ) page: 477-83   2009.9

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    PubMed

  440. Correlations of the expression of vascular endothelial growth factor B and its isoforms in hepatocellular carcinoma with clinico-pathological parameters. Reviewed

    Kanda M, Nomoto S, Nishikawa Y, Sugimoto H, Kanazumi N, Takeda S, Nakao A

    Journal of surgical oncology   Vol. 98 ( 3 ) page: 190-6   2008.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jso.21095

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MISC 18

  1. 胃癌において切除断端の顕微鏡的癌遺残は予後因子となりうるか?

    中西香企, 神田光郎, 伊藤誠二, 望月能成, 寺本仁, 石榑清, 村井俊文, 浅田崇洋, 石山聡治, 松下英信, 清水大, 田中千恵, 藤原道隆, 小寺泰弘

    日本外科学会定期学術集会(Web)   Vol. 121st   2021

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  2. Tumor detection using indocyanine green fluorescence during gastrectomy for gastric cancer

    田中千恵, 神田光郎, 佐藤敏, 中西香企, 清水大, 藤原道隆, 小寺泰弘

    日本胃癌学会総会記事   Vol. 93rd   2021

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  3. 胃癌に対するS-1術後補助化学療法の開始時期と予後に関する検討

    中西 香企, 神田 光郎, 伊藤 誠二, 望月 能成, 寺本 仁, 石榑 清, 村井 俊文, 浅田 崇洋, 石山 聡治, 小寺 泰弘

    日本消化器外科学会総会   Vol. 74回   page: P75 - 3   2019.7

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  4. 食道癌術後に発症した肺ヘルニア嵌頓の1例

    中村 俊介, 小池 聖彦, 神田 光郎, 小林 大介, 田中 千恵, 園原 史訓, 高見 秀樹, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 藤原 道隆, 小寺 泰弘

    日本臨床外科学会雑誌   Vol. 80 ( 7 ) page: 1397 - 1397   2019.7

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  5. 当科でのPTEGの使用経験

    田中 克仁, 神田 光郎, 小林 大介, 田中 千恵, 園原 史訓, 高見 秀樹, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本消化器病学会東海支部例会プログラム抄録集   Vol. 130回   page: 70 - 70   2019.6

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  6. 膵癌切除症例におけるNaples Prognostic Scoreの臨床的意義

    中川 暢彦, 山田 豪, 園原 史訓, 高見 秀樹, 林 真路, 服部 憲史, 神田 光郎, 小林 大介, 田中 千恵, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    外科と代謝・栄養   Vol. 53 ( 3 ) page: 135 - 135   2019.6

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  7. 膵癌切除症例におけるNaples Prognostic Scoreの臨床的意義

    中川 暢彦, 山田 豪, 園原 史訓, 高見 秀樹, 林 真路, 服部 憲史, 神田 光郎, 小林 大介, 田中 千恵, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    外科と代謝・栄養   Vol. 53 ( 3 ) page: 135 - 135   2019.6

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  8. 胃癌術後S-1補助化学療法の忍容性を予測する周術期因子の検討

    三輪 高嗣, 神田 光郎, 小林 大介, 田中 千恵, 園原 史訓, 高見 秀樹, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    外科と代謝・栄養   Vol. 53 ( 3 ) page: 131 - 131   2019.6

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  9. 胃癌術後S-1補助化学療法の忍容性を予測する周術期因子の検討

    三輪 高嗣, 神田 光郎, 小林 大介, 田中 千恵, 園原 史訓, 高見 秀樹, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    外科と代謝・栄養   Vol. 53 ( 3 ) page: 131 - 131   2019.6

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  10. 胃癌における術前prognostic nutrition indexの意義

    三輪 高嗣, 神田 光郎, 小林 大介, 田中 千恵, 園原 史訓, 高見 秀樹, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    外科と代謝・栄養   Vol. 53 ( 3 ) page: 136 - 136   2019.6

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  11. 胃癌における術前prognostic nutrition indexの意義

    三輪 高嗣, 神田 光郎, 小林 大介, 田中 千恵, 園原 史訓, 高見 秀樹, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    外科と代謝・栄養   Vol. 53 ( 3 ) page: 136 - 136   2019.6

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  12. 後期高齢者食道癌患者における食道亜全摘術の短期成績と術前免疫栄養因子の検討

    神田 光郎, 小池 聖彦, 田中 千恵, 小林 大介, 園原 史訓, 高見 秀樹, 服部 憲史, 林 真路, 山田 豪, 中山 吾郎

    日本食道学会学術集会プログラム・抄録集   Vol. 73回   page: 210 - 210   2019.6

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  13. 2領域郭清後頸部リンパ節再発は診断時追加郭清で制御できるか?

    小池 聖彦, 神田 光郎, 高見 秀樹, 服部 憲史, 林 真路, 田中 千恵, 小林 大介, 山田 豪, 中山 吾郎, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 119回   page: PS - 216   2019.4

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  14. 食道扁平上皮癌におけるKCNJ15遺伝子発現の臨床的意義の検討

    中村 俊介, 神田 光郎, 小林 大介, 田中 千恵, 林 真路, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 119回   page: PS - 053   2019.4

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  15. 直腸癌手術における一時的回腸人工肛門造設後の腎機能の検討

    服部 憲史, 中山 吾郎, 上原 圭介, 相場 利貞, 岩田 直樹, 神田 光郎, 林 真路, 小林 大介, 田中 千恵, 山田 豪, 小池 聖彦, 藤原 道隆, 梛野 正人, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 119回   page: SF - 099   2019.4

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  16. 局所進行膵癌に対する動脈合併切除術-長期成績の観点から見た臨床的意義の再考 膵癌に対するnew era chemo regimen登場による動脈合併膵切除の意義

    園原 史訓, 山田 豪, 高見 秀樹, 林 真路, 服部 憲史, 神田 光郎, 田中 千恵, 小林 大介, 中山 吾郎, 小池 聖彦, 藤原 道隆, 藤井 努, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 119回   page: PD - 7   2019.4

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  17. 外科専門医に求められるコンピテンシー

    高見 秀樹, 小寺 泰弘, 園原 史訓, 服部 憲史, 林 真路, 神田 光郎, 小林 大介, 田中 千恵, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆

    日本外科学会定期学術集会抄録集   Vol. 119回   page: SP - 2   2019.4

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  18. Stage II/III胃癌患者における術前Prognostic Nutritional Index値の術後合併症・予後予測因子としての意義

    笹原 正寛, 神田 光郎, 寺本 仁, 望月 能成, 伊藤 誠二, 石榑 清, 村井 俊文, 浅田 崇洋, 石山 聡治, 松下 英信, 田中 千恵, 小林 大介, 藤原 道隆, 室谷 健太, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 119回   page: PS - 1   2019.4

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Presentations 24

  1. Expression and methylation status of DENND2D in gastric cancer 胃癌における膜輸送蛋白のDENND2D発現の関する検討

    神田光郎,岩田直樹,小林大介,田中千恵,山田 豪,中山吾郎,藤井 努,杉本博行,小池聖彦,野本周嗣,藤原道隆,小寺泰弘

    第25回日本消化器癌発生学会総会 (第8回国際消化器癌発生会議) 

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    Event date: 2014.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:福岡   Country:Japan  

  2. 肝細胞癌におけるB-cell translocation gene 1発現の意義の検討

    神田光郎,大屋久晴,野本周嗣,日比野壮貴,清水 大,高見秀樹,橋本良二,岡村行泰*,岩田直樹,田中千恵,小林大介,山田 豪,藤井 努,中山吾郎,杉本博行,小池聖彦,藤原道隆,小寺泰弘(静岡がんセンター*)

    JDDW2014 第22回日本消化器関連学会週間(第56回日本消化器病学会大会、第88回日本消化器内視鏡学会総会、第18回日本肝臓学会大会、第12回日本消化器外科学会大会) 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸   Country:Japan  

  3. B-cell translocation gene 1 serves as a novel prognostic indicator of hepatocellular carcinoma. International conference

    Mitsuro Kanda, Dai Shimizu, Hiroyuki Sugimoto, Hisaharu Oya, Soki Hibino, Hideki Takami, Ryoji Hashimoto, Yukiyasu Okamura, Suguru Yamada, Tsutomu Fujii, Goro Nakayama, Masahiko Koike, Shuji Nomoto, Michitaka Fujiwara, Yasuhiro Kodera

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    Event date: 2014.9

    Language:English   Presentation type:Poster presentation  

    Country:Spain  

  4. 胃癌の部位・形態別subtypeにおける,Melanoma-associated antigen D2発現の臨床的意義の検討

    神田光郎,小林大介,田中千恵,山田 豪,藤井 努,中山吾郎,小池聖彦,野本周嗣,藤原道隆,小寺泰弘

    第69回日本消化器外科学会総会 

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    Event date: 2014.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:郡山   Country:Japan  

  5. セクレチン負荷十二指腸液中GNAS遺伝子変異検出の膵嚢胞性病変スクリーニングへの応用

    神田光郎,藤井 努,山田 豪,杉本博行,野本周嗣,藤原道隆,小寺泰弘,Michael Goggins* (Johns Hopkins Medical Institute*)

    第45回日本膵臓学会大会 

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    Event date: 2014.7

    Language:Japanese  

    Venue:小倉   Country:Japan  

  6. 術前CT volumetryにおける残膵実質体積の膵頭十二指腸切除術後膵瘻発生予測能の検討 Estimated Pancreatic Parenchymal Remnant Volume Accurately Predicts Clinically Relevant Pancreatic Fistula after Pancreatoduodenectomy

    神田光郎,藤井 努,山田 豪,末永雅也,高見秀樹,杉本博行,野本周嗣,小寺泰弘 Mitsuro Kanda, Tsutomu Fujii, Suguru Yamada, Masaya Suenaga, Hideki Takami, Hiroyuki Sugimoto, Shuji Nomoto, Yasuhiro Kodera

    第26回日本肝胆膵外科学会・学術集会 

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    Event date: 2014.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:和歌山   Country:Japan  

  7. Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts

    Mitsuro Kanda, Tsutomu Fujii, Suguru Yamada, Naoki Iwata, Daisuke Kobayashi, Chie Tanaka, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Shuji Nomoto, Michitaka Fujiwara, Yasuhiro Kodera, Michael Goggins*(Department of Pathology, Johns Hopkins University*)

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    Event date: 2014.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  8. 当教室における膵神経内分泌腫瘍(PNET)切除例の臨床病理学的検討からのNCCNガイドラインの検証

    神田光郎,藤井 努,山田 豪,岩田直樹,小林大介,田中千恵,中山吾郎,杉本博行,小池聖彦,野本周嗣,藤原道隆,小寺泰弘

    第114回日本外科学会定期学術集会 

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    Event date: 2014.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  9. 胃癌における膜輸送蛋白DENND2D発現と予後に関する検討

    神田光郎,岩田直樹,小林大介,田中千恵,山田 豪,中山吾郎,藤井 努,杉本博行,小池聖彦,野本周嗣,藤原道隆,小寺泰弘

    第47回制癌剤適応研究会 

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    Event date: 2014.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  10. Overexpression of melanoma-associated antigen D4 as an independent prognostic factor in squamous cell carcinoma of the esophagus. International conference

    Mitsuro Kanda, Hisaharu Oya, Soki Hibino, Hideki Takami, Dai Shimizu, Masahiko Koike, Shuji Nomoto, Suguru Yamada, Tsutomu Fujii, Goro Nakayama, Hiroyuki Sugimoto, Michitaka Fujiwara, Yasuhiro Kodera

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    Event date: 2014.1

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  11. Blumgart変法縫合による空腸漿膜パッチを用いた尾側膵切除後膵瘻防止の試み

    神田光郎,藤井努,山田豪,小林大介,田中千恵,中山吾郎,杉本博行,小池聖彦,野本周嗣,藤原道隆,小寺泰弘

    第75回日本臨床外科学会総会 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋   Country:Japan  

  12. 膵癌予後予測因子としての術前血清腫瘍マーカーの検討

    神田光郎,藤井努,高見秀樹,末永雅也,山田豪,田中千恵,小林大介,中山吾郎,杉本博行,小池聖彦,野本周嗣,藤原道隆,小寺泰弘

    JDDW 2013 第21回日本消化器関連学会週間 (第11回日本消化器外科学会大会・第55回日本消化器病学会大会・第86回日本消化器内視鏡学会総会・第17回日本肝臓学会大会) 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  13. Neoadjuvant chemotherapy with S-1 in patients with borderline resectable pancreatic cancer with involvement of the major vessels. International conference

    Mitsuro Kanda, Tsutomu Fujii, Soki Hibino, Masaya Suenaga, Suguru Yamada, Norio Okumura, Daisuke Kobayashi, Chie Tanaka, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Shuji Nomoto, Michitaka Fujiwara, Yasuhiro Kodera

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    Event date: 2013.9

    Language:English   Presentation type:Poster presentation  

    Country:China  

  14. Blumgart変法縫合による空腸漿膜パッチを用いた尾側膵切除後膵瘻防止の試み

    神田光郎,藤井 努,山田 豪,末永雅也,高見秀樹,丹羽由紀子,服部正嗣,杉本博行,野本周嗣,小寺泰弘

    第40回日本膵切研究会 

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    Event date: 2013.8

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:高松   Country:Japan  

  15. Combination of Preoperative Serum CEA and CA19-9 is a Simple and Prominent Predictor in Pancreatic Cancer. International conference

    Mitsuro Kanda, Tsutomu Fujii, Masaya Suenaga, Hideki Takami, Suguru Yamada, Daisuke Kobayashi, Chie Tanaka, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Shuji Nomoto, Michitaka Fujiwara, Shin Takeda, Yasuhiro Kodera

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    Event date: 2013.8

    Language:English   Presentation type:Poster presentation  

    Country:Serbia  

  16. セクレチン負荷十二指腸液中TP53変異の,膵癌・高度異形病変診断における有用性の検討

    神田光郎,藤井努,山田豪,小林大介,田中千恵,中山吾郎,杉本博行,小池聖彦,野本周嗣,藤原道隆,竹田伸,小寺泰弘,Michael Goggins* (*Department of Pathology, Johns Hopkins Medical Institutions)

    第44回日本膵臓学会大会 

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    Event date: 2013.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:仙台   Country:Japan  

  17. 混合型IPMNの由来別細分類の臨床的意義と治療方針の検討

    神田光郎,藤井努,山田豪,末永雅也,杉本博行,小池聖彦,野本周嗣,藤原道隆,竹田伸,小寺泰弘

    第68回日本消化器外科学会総会 

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    Event date: 2013.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:宮崎   Country:Japan  

  18. PANCREATODUODENECTOMY WITH PORTAL VEIN RESECTION IS FEASIBLE AND BENEFICIAL FOR ELDERLY PATIENTS WITH PANCREATIC CANCER. International conference

    Mitsuro Kanda, Tsutomu Fujii, Hideki Takami, Hisaharu Ohya, Masaya Suenaga, Suguru Yamada, Daisuke Kobayashi, Chie Tanaka, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Shuji Nomoto, Michitaka Fujiwara, Yasuhiro Kodera

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    Event date: 2013.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Spain  

  19. 膵嚢胞性病変スクリーニングにおける,セクレチン負荷十二指腸採取液中GNAS遺伝子変異検出の有用性

    神田光郎,藤井努,山田豪,小林大介,田中千恵,中山吾郎,杉本博行,小池聖彦,野本周嗣,藤原道隆,竹田伸,小寺泰弘,Michael Goggins* (ジョンズホプキンス大学 病理部*)

    第25回日本肝胆膵外科学会・学術集会 

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    Event date: 2013.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:宇都宮   Country:Japan  

  20. 膵上皮内腫瘍性病変の初期発生段階における体細胞変異の検討

    神田光郎,藤井努,山田豪,小林大介,田中千恵,中山吾郎,杉本博行,小池聖彦,野本周嗣,藤原道隆,竹田伸,小寺泰弘,Goggins Michael* (Johns Hopkins大学病理学*)

    第113回日本外科学会定期学術集会 

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    Event date: 2013.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  21. 膵癌における術前栄養免疫学的予後予測因子の検討

    神田光郎,藤井努,長井俊志,山田豪,小林大介,田中千恵,中山吾郎,杉本博行,小池聖彦,野本周嗣,藤原道隆,竹田伸,中尾昭公*,小寺泰弘 (名古屋セントラル病院*)

    第99回日本消化器病学会総会 

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    Event date: 2013.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:鹿児島   Country:Japan  

  22. 膵頭部癌に対するMesenteric approachによる上腸間膜動脈周囲リンパ節・神経叢郭清

    神田光郎,藤井努,神崎章之,長井俊志,杉本博行,粕谷英樹,野本周嗣,竹田伸,中尾昭公

    第65回日本消化器外科学会総会 

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    Event date: 2010.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:下関   Country:Japan  

  23. Non-touch isolated pancreatoduodenectomy with a mesenteric approach for pancreatic head cancer. International conference

    Mitsuro Kanda, Akimasa Nakao, Tsutomu Fujii, Shunji Nagai, Takashi Sugae, Masamichi Hayashi, Akiyuki Kanzaki, Yukiyasu Okamura, Suguru Yamada, Hiroyuki Sugimoto, Shuji Nomoto, Shin Takeda

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    Event date: 2010.7

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  24. 肝細胞癌におけるFibulin-1発現と、その調節機序に関する検討

    神田光郎,野本周嗣,岡村行泰,林真路,藤井努,杉本博行,粕谷英樹,竹田伸,中尾昭公

    第110回日本外科学会定期学術集会 

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    Event date: 2010.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

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KAKENHI (Grants-in-Aid for Scientific Research) 14

  1. 臓器嗜好性に焦点をあてた食道癌転移の分子機序解明からの創薬研究

    Grant number:21K19525  2021.7 - 2024.3

    科学研究費助成事業  挑戦的研究(萌芽)

    小寺 泰弘, 神田 光郎, 田中 千恵, 清水 大

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    食道癌転移経路特異的Transcriptome解析により、申請者らの仮説に一致して血行性転移群とリンパ行性転移で発現パターンが明瞭に異なるクラスターがあることが示され、血行性転移関連5分子(VWA5B2、CFAP47、NECAB2、SYCE3、RPL3L)、リンパ行性転移関連3分子(C1QL4、CCDC87、CAMK2N2)を厳選している。
    これらの食道癌転移形式別関連分子の機能解析・発現解析を行うことで、食道癌転移の分子生物学的機序の解明を通じ、食道癌予後を劇的に改善しうる分子標的治療薬と、その奏効度を事前に予測しうるコンパニオン診断法開発の基盤となるデータを得ることを目的とする。

  2. 細胞接着因子を標的とするデュアル修飾型アンチセンス核酸を用いた革新的癌治療薬創出

    Grant number:21H02984  2021.4 - 2025.3

    科学研究費助成事業  基盤研究(B)

    小寺 泰弘, 神田 光郎, 笠原 勇矢, 田中 千恵, 清水 大, 小比賀 聡

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    Authorship:Coinvestigator(s) 

    本研究では、細胞接着因子を標的としたアンチセンス核酸医薬による新たな胃癌分子標的治療薬およびコンパニオン診断技術開発を目指して、以下を実施する。
    1) アンチセンス核酸スクリーニング、2) メカニズム解明(機能解析、シグナル解析、KOマウス解析、正常組織中発現解析)、3) in vitro活性評価(濃度依存性の活性、癌種横断的活性評価)、4) in vivo活性評価(皮下腫瘍モデル、同所移植モデルでの薬効評価)、5) 毒性評価とオフターゲット探索、6) コンパニオン診断(治療前生検、手術検体での免疫染色法による発現解析)

  3. 口腔、咽頭、喉頭、食道扁平上皮癌における唾液腫瘍マーカーの抽出

    Grant number:21K08631  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    野本 周嗣, 高橋 真理子, 後藤 満雄, 神田 光郎, 今澤 正彦

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    口腔から食道までの粘膜、組織を覆う採取しやすいサンプルであり、患者の状態をよく反映する安定した検体である唾液の細菌叢変化と遺伝子発現変化が咽頭、喉頭、食道までの扁平上皮癌患者、癌の高リスク者をいかなる変化で検出できるか、臨床応用可能なマーカーを抽出するようにしたい。

  4. 高齢消化器癌手術症例における術後自立度低下に関するリスク評価と介入の有効性の検討

    Grant number:21K11620  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    田中 千恵, 神田 光郎, 渡邊 一久, 小寺 泰弘, 室谷 健太, 栗本 景介, 藤原 道隆

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    本研究は,消化器癌における様々な術式の自立度への影響と複数の診療科を含む多職種横断的な介入の効果を包括的に把握し,高齢者に対する癌治療のエビデンス構築の一助となるデータを構築することを目的とする。まず,術前後の自立度の変化について調査票と血清バイオマーカー値の両面から評価する。次に,自立度が低下する患者については,老年科専門医・リハビリテーション・栄養サポートチームによる介入で機能維持を図り,ひいては,事前に自立度が低下する群を予測し,予防的介入が可能となることを見込む。

  5. Development of amido-bridged nucleic acid-modified antisense oligonucleotides to treat gastrointestinal malignancies

    Grant number:20K21629  2020.7 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

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    Authorship:Principal investigator 

    Grant amount:\6370000 ( Direct Cost: \4900000 、 Indirect Cost:\1470000 )

  6. Development of monoclonal antibody targeting CHRNB2 to treat gastric cancer

    Grant number:20H03750  2020.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Principal investigator 

    Grant amount:\17550000 ( Direct Cost: \13500000 、 Indirect Cost:\4050000 )

  7. Multi-omics analysis to identify predictors for treatment efficacy of perioperative chemotherapy in advanced gastric cancer

    Grant number:19K22653  2019.6 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

    KODERA Yasuhiro

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    As a pivotal clinical trial for development of treatment strategy for clinical stage III gastric cancer, a multicenter, randomized phase III clinical trial to confirm the superiority of addition of preoperative adjuvant chemotherapy with S-1 + oxaliplatin (SOX) over standard treatment is ongoing. If the efficacy of chemotherapy can be predicted before decision making of treatment, physicians can select the most appropriate treatment method for each patient, which will have great significance not only in terms of treatment effect but also in terms of medical economics. In this study, we performed a multi-omics analysis and identified candidate markers for the efficacy of preoperative SOX therapy in plasma samples (protein and microRNA). Moreover, we confirmed the feasibility of the Cancer Panel using endoacopic biopsy FFPE samples. The results of this study will greatly enhance the quality of a future biomarker study.

  8. 食道癌に対する新たな抗体医薬とコンパニオン診断技術の開発研究

    Grant number:19K09140  2019.4 - 2022.3

    科学研究費助成事業  基盤研究(C)

    小池 聖彦, 田中 千恵, 小林 大介, 神田 光郎, 澤木 康一, 小寺 泰弘

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    多様な進展経路を持つ食道癌は男女ともに癌死亡者数が増加しており、その克服は重要な課題である。食道癌の治療成績を改善するには、病態解明と分子標的治療薬開発につながる新規関連分子の同定が望まれる。本研究では、食道扁平上皮癌の細胞株と組織マイクロアレイで高頻度に発現亢進するレセプター分子を探索し同定したレセプターNに着目し、治療の奏効度を予測するコンパニオン診断法の確立と並行して研究を進める。本研究計画の目的は食道癌におけるレセプターNの機能を明らかにし、これを標的とした創薬ならびに診断法の開発に繋げることである。
    食道癌は多様な進展経路を持つ予後不良な疾患であり、本邦において男女ともに癌死亡者数が増加している。従来の殺細胞性抗腫瘍剤のコンプライアンスが得られにくく効果も限定的であるため、治療成績改善のためには治療選択肢を拡大させうる分子標的治療薬の開発が望まれている。我々は、既存の分子標的治療薬とは全く異なる標的としてneuronal pentraxin receptor (NPTXR) を同定し、これに対する特異的抗体医薬開発の糸口をつかむことを目的に本研究を進めている。また同時に、個別化治療の実現に向けて重要な、奏効度を事前に予測しうるコンパニオン診断法開発に向けてのデータ構築を行っていく。shRNAを用いた安定的NPTXRノックダウン食道扁平上皮癌細胞株を樹立し、細胞機能解析を行ったところ、癌進展に重要な細胞増殖能、浸潤能が有意に低下することを明らかにした。また、NPTXRノックダウンにより食道癌のkey drugである5-FUの感受性が改善することも発見した。抗原性・親水性予測に基づいて抗NTPXR抗体を取得した。NPTXRの悪性腫瘍における役割には未知の部分が大きく、どのようなsignaling pathwayとの干渉を有するのかを知ることは、その特性を理解するために重要である。Antibody arrayを用いて親株と安定的NPTXRノックダウン株における細胞内signaling pathwayのリン酸化について網羅的に比較したところ、Akt-mTORのシグナルのリン酸化がNPTXRにより抑制されていた。引き続き研究計画にもとづいて、食道扁平上皮癌細胞におけるNPTXRの機能解析、抗腫瘍剤感受性への影響、癌関連主要pathwayへの干渉、抗NPTXR抗体の食道癌全身転移モデル治療効果の評価、コンパニオン診断薬開発のための臨床検体中NPTXR発現解析を進めていく。
    樹立したshRNAを用いた安定的NPTXRノックダウン食道扁平上皮癌細胞株を用いて、細胞機能解析(細胞増殖能、浸潤能)を実施した。さらに、薬剤感受性への影響を調べるべく、NPTXRノックダウンの有無によるFUの感受性変化についても検討した。次年度に活性評価を行う予定の抗NTPXR抗体を取得した。シグナル解析の入り口となる網羅的細胞内signaling pathwayリン酸化解析を実施し、Akt-mTORのシグナルのリン酸化がNPTXRにより抑制されていることを発見した。おおむね研究計画に沿って進捗している。
    引き続き、shRNAによる安定的ノックダウン株を用いて癌細胞機能の変化を調べる。親株とノックダウン株の間でアポトーシス細胞比、ミトコンドリア膜電位活性、Caspase活性、細胞周期の変化を調べるととともに、癌の転移進展に重要な遊走能、接着能を順次評価していく。in vivo実験として、マウス皮下腫瘍モデルでの造腫瘍能を比較する。親株と安定的レセプターNノックダウン株の間で食道癌のkey drugであるCDDPの感受性をWST-8法で比較する。シグナル解析として、Akt-mTORシグナルに着目して関連分子のリン酸化をWestern blotting法で調査する。抗NPTXR抗体の食道癌細胞増殖抑制効果を調べる。コンパニオン診断薬開発に向けて、食道癌原発巣組織中発現と臨床データの相関解析を行う。取得したデータをまとめ、英文論文執筆を開始する。

  9. 介入による消化器癌周術期高齢者機能の改善と機能低下に影響するバイオマーカー探索

    Grant number:17K01841  2017.4 - 2022.3

    科学研究費助成事業  基盤研究(C)

    田中 千恵, 神田 光郎, 小寺 泰弘, 室谷 健太, 柳川 まどか, 藤原 道隆

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    1年間でさらに症例を集積したため、術前化学療法を施行した症例16例を除く41例を対象として再度解析を行った。
    令和元年度の報告と同様、機能評価のスコアの平均値は、自立度(BADL、IADL)、認知機能(MMSE)、抑うつ(GDS-15)、錯乱(NEECHAM)において、術前と比べて退院時・術後6ヶ月のいずれも明らかな低下を認めなかった。これに対して、栄養(MNA-SF)および認知機能(CDR-J)は術前と比べて退院時に有意にスコアの低下を認めた。このため、さらに解析を追加し、機能評価の各項目のスコアの異常値を来す割合に関して評価を行った。自立度を示すIADLスコアが異常値を来す割合は、術前が5%に対して退院時が13%(p=0.0481)、術後6ヶ月が8%(p=0.3895)であった。栄養を示すMNA-SFのスコアが異常値を来す割合は、術前が35%に対して退院時が83%(p<0.0001)、術後6ヶ月が55%(p=0.0045)であった。他の項目のスコアは術前と比べて退院時、術後6ヶ月に有意な低下は認めなかった。さらに、術前と比べて退院時にBADLスコアの低下に関連した因子として、術後合併症の発生が、IADLスコアの低下に関連する因子としてせん妄が挙げられた。今回の検討においても、認知機能の低下と術前バイオマーカーの値に関連は認めなかった。さらにバイオマーカー探索を続ける。
    高齢者機能評価を用いた検討の結果、術後自立度が低下する症例群が存在することがわかった。また認知機能については手術との関連の可能性が確認された。
    予定より時間を要したものの令和元年度末をもって基本的な解析を終了した。令和2年度は成果発表を行う予定であったが、COVID-19感染症の影響を受けて、ほとんど成果発表できなかったため1年の延長手続きを行った。
    次年度は令和2年度に行う予定であった成果発表を行う予定である。また、想定外に1年の時間を得たため、さらなる症例集積と解析を追加する。

  10. Molecule target for treatment and companion diagnostic tool of peritoneal dissemination in gastric cancer

    Grant number:17H04281  2017.4 - 2020.3

    KODERA Yasuhiro

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    Peritoneal metastasis is a frequent cause of death in patients with gastric cancer. The pathophysiology and thus targets for treatment are unknown. Synaptotagmin XIII (SYT13) was expressed in patients with peritoneal recurrence of gastric cancer. Inhibition of SYT13 expression in gastric cancer cell lines was associated with decreased invasion and migration ability of the cells. In vivo experiments using a mouse xenograft model of gastric cancer showed that intraperitoneal administration of SYT13-specific small interfering RNA or antibodies significantly inhibited the growth of peritoneal nodules and prolonged survival. SYT13 expression in primary gastric cancer tissues or ascites fluids had diagnostic potential both in the detection and prediction of peritoneal metastasis of gastric cancer. SYT13 may also be a promising target for the treatment of peritoneal metastasis of gastric cancer.

  11. The diagnostic performance and mechanisms of the release into the circulation of novel serum biomarkers for gastric cancer

    Grant number:17K10581  2017.4 - 2020.3

    KANDA Mitsuro

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    Development of high-performance serum biomarkers will likely improve treatment outcomes of patients with gastric cancer (GC). We conducted a prospective multicenter observational study aimed at validating the diagnostic performance of these potential markers. We analyzed serum levels before and after surgery of the three potential biomarkers in patients with GC and healthy volunteers. Quantification of serum and GC tissue levels was performed using an ELISA. Area under the curve values that discriminated patients with GC from healthy controls were-0.7058, 0.6188, and 0.5031 for ANOS1, DPYSL3, and MAGED2, respectively. Serum ANOS1 levels were significantly elevated in patients with stage I GC compared with those of healthy controls and decreased after resection of primary GC lesions. The combination of serum ANOS1 and DPYSL3 levels increased the AUC value that discriminated patients with GC from healthy controls.

  12. Expression and DNA methylation of SAMSN1 is associated with the malignant phenotype of hepatocellular carcinoma

    Grant number:16K19890  2016.4 - 2018.3

    EZAKA Kazuhiro

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    Authorship:Other 

    Identification of sensitive biomarkers for hepatocellular carcinoma (HCC) is required to achieve efficacious personalized therapy. We investigated its expression and methylation status of SAMSN1 in HCC. Analysis of HCC cell lines revealed that hypermethylation of the SAMSN1 promoter correlated with decreased expression of SAMSN1 mRNA and DNA demethylation increased SAMSN1 transcription. SAMSN1 was expressed at significantly lower levels in tumor tissue compared with the corresponding noncancerous tissues. Patients with extrahepatic recurrence exhibited the lowest levels of SAMSN1 expression in resected HCC tissues. The multivariate analysis identified SAMSN1 as an independent prognostic factor of HCC progression. The expression pattern of tissue SAMSN1 protein correlated with that of SAMSN1 mRNA. Circulating DNA methylation of SAMSN1 was difficult to be detected in serum samples. Our findings indicate that tissue SAMSN1 status represent a novel biomarker of the phenotype of HCC.

  13. Identification of molecules driving hepatic metastasis formation of gastric cancer cells

    Grant number:16K19889  2016.4 - 2018.3

    TANAKA Yuri

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    Authorship:Other 

    Liver metastasis remains a serious problem in the management of gastric cancer (GC). Transcriptome data identified the overexpression of synaptotagmin VII (SYT7) in GC tissues with hepatic metastasis. SYT7 knockout inhibited the proliferation of GC cells and attenuated cell migration, invasion, and adhesion. The tumorigenicity of SYT7 knockout cells was moderately reduced in a mouse model of subcutaneous metastasis and was more strikingly attenuated in a model of hepatic metastasis. The SYT7 levels in the primary GC tissues were significantly associated with hepatic recurrence, metastasis, and adverse prognosis. SYT7 represents a tool for prediction and monitoring of hepatic metastasis from GC as well as being a promising therapeutic target.

  14. Elucidation and clinical application of the mechanism of inhibition of liver damage progression by EGFR inhibitor

    Grant number:15K10161  2015.4 - 2018.3

    FUJII TSUTOMU

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    Authorship:Coinvestigator(s) 

    In recent years, researchers reported the effect of inhibiting cirrhosis by epidermal growth factor receptor (EGFR) inhibitors in animal models (Hepatology 2014). In this research, we clarified the mechanism of this phenomenon concretely and aimed at the development of a treatment method from a new viewpoint that suppresses cirrhotic changes of the liver in humans. Examination of protein expression in rat cirrhosis suppression model, examination of marker expression of Hepatic Stellate Cell, and isolation culture and examination of gene / protein expression in human HCC specimens, were performed.

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