Updated on 2021/11/02

写真a

 
KODAMA Tetsuya
 
Organization
Graduate School of Pharmaceutical Sciences Department of Basic Medicinal Sciences Structural Biology Associate professor
Cellular and Structural Physiology Institute Associate professor
Graduate School
Graduate School of Pharmaceutical Sciences
Undergraduate School
School of Science
Title
Associate professor
Contact information
メールアドレス

Degree 1

  1. 博士(薬学) ( 2004.3   北海道大学 ) 

Research Interests 1

  1. 化学系薬学 創薬化学 核酸化学 生体関連化学 生物分子化学

Research Areas 1

  1. Others / Others  / Nucleic Acids Chemistry

Research History 4

  1. 名古屋大学大学院創薬科学研究科、准教授

    2012.4

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    Country:Japan

  2. 大阪大学大学院薬学研究科、助教

    2007.4 - 2012.3

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    Country:Japan

  3. 大阪大学大学院薬学研究科、助手

    2006.4 - 2007.3

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    Country:Japan

  4. ジョンズホプキンス大学、日本学術振興会海外特別研究員

    2004.4 - 2006.3

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    Country:Japan

Education 2

  1. Hokkaido University   Graduate School, Division of Pharmaceutical Sciences

    - 2004.3

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    Country: Japan

  2. Hokkaido University   Faculty of Pharmaceutical Science

    - 1999.3

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    Country: Japan

Professional Memberships 6

  1. 日本薬学会   会員

    2000.2

  2. 日本化学会   会員

    2009.10

  3. 有機合成化学協会   会員

    2011.4

  4. 日本核酸医薬学会   会員、世話人

    2015.4

  5. 日本核酸化学会   会員

    2017.11

  6. アンチセンスDNA/RNA研究会   会員

    2009.11 - 2015.3

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Awards 1

  1. 平成21年度日本薬学会近畿支部奨励賞

    2010.1   日本薬学会近畿支部  

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    Country:Japan

 

Papers 54

  1. Recent developments of artificial functional oligo nucleic acids Reviewed

    Moai Yoshihiro, Kodama Tetsuya

    TETRAHEDRON LETTERS   Vol. 61 ( 14 )   2020.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.tetlet.2020.151708

    Web of Science

  2. Synthesis of selenomethylene-locked nucleic acids (SeLNA) nucleoside unit bearing an adenine base

    Moai Yoshihiro, Hiroaki Hidekazu, Obika Saoshi, Kodama Tetsuya

    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS     page: 1-10   2019.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/15257770.2019.1675169

    Web of Science

    PubMed

  3. Synthesis of Uracil-Iodonium(III) Salts for Practical Utilization as Nucleobase Synthetic Modules

    Takenaga Naoko, Hayashi Takumi, Ueda Shohei, Satake Hiroyuki, Yamada Yoichi, Kodama Tetsuya, Dohi Toshifumi

    MOLECULES   Vol. 24 ( 17 )   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/molecules24173034

    Web of Science

    PubMed

  4. High-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal Pathway Reviewed

    Seiji Ishii, Kenji Fukui, Satoshi Yokoshima, Kazuo Kumagai, Youko Beniyama, Tetsuya Kodama, Tohru Fukuyama, Takayoshi Okabe, Tetsuo Nagano, Hirotatsu Kojima, Takato Yano

    Scientific Reports     page: 4029   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi:10.1038/s41598-017-03567-2

  5. Synthesis and Properties of 7-Deazapurine- and 8-Aza-7-deazapurine-Locked Nucleic Acid Analogues: Effect of the Glycosidic Torsion Angle Reviewed

    Takashi Hara, Tetsuya Kodama, Yumi Takegaki, Kunihiko Morihiro, Kosuke Ramon Ito, and Satoshi Obika

    The Journal of Organic Chemistry   Vol. 82 ( 1 ) page: 25-36   2016.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: DOI: 10.1021/acs.joc.6b02525

  6. Systematic Evaluation of Biophysical and Functional Characteristics of Selenomethylene-Locked Nucleic Acid-Mediated Inhibition of miR-21 Reviewed

    Smita Nahar, Amrita Singh, Kunihiko Morihiro, Yoshihiro Moai, Tetsuya Kodama, Satoshi Obika, Souvik Maiti

    Biochemistry   Vol. 55 ( 50 ) page: 7023-7032   2016.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: DOI: 10.1021/acs.biochem.6b00895

  7. Wavelength-selective light-triggered strand exchange reaction Reviewed

    Kunihiko Morihiro, Tetsuya Kodama, Shohei Mori, Shin-ichi Tsunoda, Satoshi Obika

    Organic & Biomolecular Chemistry   Vol. 14 ( 5 ) page: 1555-1558   2015.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: DOI: 10.1039/c5ob02369f

  8. Synthesis and hybridization property of a boat-shaped pyranosyl nucleic acid containing an exocyclic methylene group in the sugar moiety. Reviewed

    Kazuto Mori, Tetsuya Kodama, Satoshi Obika.

    Bioorganic & Medicinal Chemistry   Vol. 23 ( 1 ) page: 33-37   2014.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: DOI:10.1016/j.bmc.2014.11.030

  9. Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with 18F-incorporated oligodeoxynucleotides. Reviewed

    Hidefumi Mukai, Daiki Ozaki, Yilong Cui, Takeshi Kuboyama, Hiroko Yamato-Nagata, Kayo Onoe, Maiko Takahashi, Yasuhiro Wada, Takeshi Imanishi, Tetsuya Kodama, Satoshi Obika, Masaaki Suzuki, Hisashi Doi, Yasuyoshi Watanabe.

    Journal of Controlled Release   Vol. 180   page: 92-99   2014.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: DOI: 10.1016/j.jconrel.2014.02.014

  10. Photoinduced changes in hydrogen bonding patterns of 8-thiopurine nucleobase analogues in a DNA strand. Reviewed

    Kunihiko Morihiro, Tetsuya Kodama, Shohei Mori, Satoshi Obika.

    Organic & Biomolecular Chemistry   Vol. 12 ( 15 ) page: 2468-2473   2014.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: DOI: 10.1039/ c3ob42427h

  11. Light-triggered strand exchange reaction using the change in the hydrogen bonding pattern of a nucleobase analogue. Reviewed

    Kunihiko Morihiro, Tetsuya Kodama, Reiko Waki, Satoshi Obika.

    Chemical Science   Vol. 5 ( 2 ) page: 744-750   2013.10

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  12. Selenomethylene Locked Nucleic Acid Enables Reversible Hybridization in Response to Redox Changes.

    Kunihiko Morihiro, Tetsuya Kodama, Kentefu, Yoshihiro Moai, Rakesh N. Veedu, and Satoshi Obika.

    Angew. Chem. Int. Ed.   Vol. 52 ( 19 ) page: 5074-5078   2013.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: DOI: 10.1002/anie.201300555

  13. Amido-Bridged Nucleic Acids (AmNAs): Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro Antisense Potency. Reviewed

    Aiko Yahara, Ajaya Ram Shrestha, Tsuyoshi Yamamoto, Yoshiyuki Hari, Takashi Osawa, Masaki Yamaguchi, Masaru Nishida, Tetsuya Kodama and Satoshi Obika

    ChemBioChem   Vol. 13 ( 17 ) page: 2513-2516   2012.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: DOI: 10.1002/cbic.201200506

  14. Synthesis of selenomethylene-locked nucleic acid (SeLNA)-modified oligonucleotides by polymerases. Reviewed

    Megan Wheeler, Antoine Chardon, Astrid Goubet, Kunihiko Morihiro, Sze Yee Tsan, Stacey L. Edwards, Tetsuya Kodama, Satoshi Obika and Rakesh N. Veedu.

    Chemical Communications   Vol. 48 ( 89 ) page: 11020-11022   2012.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: DOI: 10.1039/C2CC36464F

  15. Hybridizing ability and nuclease resistance profile of backbone modified cationic phosphorothioate oligonucleotides. Reviewed

    S.M. Abdur Rahman, Takeshi Baba, Tetsuya Kodama, Md. Ariful Islam, Satoshi Obika.

    Bioorganic & Medicinal Chemistry,   Vol. 20 ( 13 ) page: 4098-4103   2012.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: DOI. 10.1016/j.bmc.2012.05.009

  16. Synthesis and evaluation of novel caged DNA alkylating agents bearing 3,4-epoxypiperidine structure. Reviewed

    Yuji Kawada, Tetsuya Kodama, Kazuyuki Miyashita, Takeshi Imanishi, Satoshi Obika

    Organic & Biomolecular Chemistry   Vol. 10 ( 26 ) page: 5102-5108   2012.5

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    DOI: DOI. 10.1039/c2ob25366f

  17. 光るRNAアルファベット: チエノ[3,4-d]ピリミジン型核酸塩基

    兒玉哲也

    化学   Vol. 67 ( 4 ) page: 67-68   2012.3

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  18. Cleavage of oligonucleotides containing a P3'->N5' phosphoramidite linkage mediated by single-stranded oligonucleotide templates. Reviewed

    Kosuke Ramon Ito, Tetsuya Kodama, Futaba Makimura, Noritsugu Hosoki, Tomohisa Osaki, Ayako Orita, Takeshi Imanishi, Satoshi Obika

    Molecules   Vol. 16 ( 12 ) page: 10695-10708   2011.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/molecules161210695

  19. Design, synthesis and properties of boat-shaped glucopyranosyl nucleic acid. Reviewed

    Kazuto Mori, Tetsuya Kodama, Satoshi Obika

    Organic Letters   Vol. 13 ( 22 ) page: 6050–6053   2011.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/ol2025229

  20. Repair of the major lesion resulting from C5'-oxidation of DNA. Reviewed

    Kwan-Young Jung, Tetsuya Kodama, Marc M. Greenberg

    Biochemistry   Vol. 50 ( 28 ) page: 6273–6279   2011.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/bi200787e

  21. Benzylidene acetal-type bridged nucleic acids: changes in properties upon cleavage of the bridge triggered by external stimuli. Reviewed

    Kunihiko Morihiro, Tetsuya Kodama, Satoshi Obika

    Chemistry - A European Journal   Vol. 17 ( 28 ) page: 7918–7926   2011.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/chem.201100541

  22. Bridged nucleic acid conjugates at 6'-thiol: synthesis, hybridization properties and nuclease resistances. Reviewed

    Kazuto Mori, Tetsuya Kodama, Takeshi Baba, Satoshi Obika.

    Organic &. Biomolecular Chemistry   Vol. 9 ( 14 ) page: 5272-5279   2011.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/C1OB05469D

  23. 外部刺激応答型人工核酸スイッチの設計と合成. Reviewed

    兒玉哲也

      Vol. 131 ( 1 ) page: 101-111   2011.1

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  24. 架橋型人工核酸BNAの開発(4):外部刺激応答型人工核酸スイッチへの展開 Reviewed

    兒玉哲也, 今西武, 小比賀聡

      Vol. 14 ( 2 ) page: 35-44   2010.12

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  25. A novel bridged nucleoside bearing a conformationally switchable sugar moiety in response to redox changes Reviewed

    Takeshi Baba, Tetsuya Kodama, Kazuto Mori, Takeshi Imanishi, and Satoshi Obika.

    Chemical Communications   Vol. 46   page: 8058-8060.   2010.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/C0CC02484H

  26. Double-stranded DNA-templated cleavage of oligonucleotides containing a P3'->N5' linkage triggered by triplex formation: the effects of chemical modifications and remarkable enhancement in reactivity. Reviewed

    Kosuke Ramon Ito, Tetsuya Kodama, Masaharu Tomizu, Yoshinori Negoro, Ayako Orita, Tomohisa Osaki, Noritsugu Hosoki, Takaya Tanaka, Takeshi Imanishi, and Satoshi Obika.

    Nucleic Acids Research   Vol. 38 ( 20 ) page: 7332-7342.   2010.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/nar/gkq600

  27. Synthesis, RNA selective hybridization and high nuclease resistance of an oligonucleotide containing novel bridged nucleic acid with cyclic urea structure. Reviewed

    Masaru Nishida, Takeshi Baba, Tetsuya Kodama, Aiko Yahara, Takeshi Imanishi, and Satoshi Obika.

    Chemical Communications   Vol. 46 ( 29 ) page: 5283-5285   2010.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/C0CC00154F

  28. Synthesis and evaluation of novel 3,4-epoxypiperidines as efficient DNA alkylating agents. Reviewed

    Yuji Kawada, Tetsuya Kodama, Kazuyuki Miyashita, Takeshi Imanishi, and Satoshi Obika.

    Heterocycles   Vol. 80 ( 2 ) page: 1249-1265   2009.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3987/COM-09-S(S)112

  29. Development of light-responsive BNA toward the spatiotemporal control of gene expression.

    Kunihiko Morihiro, Tetsuya Kodama, Masaru Nishida, Takeshi Imanishi, and Satoshi Obika.

    Nucleic Acids Symp Ser   Vol. 53   page: 187-188   2009.9

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  30. Synthesis and properties of a novel 2',4'-BNA bearing a urea bridged structure.

    Aiko Yahara, Masaru Nishida, Takeshi Baba, Tetsuya Kodama, Takeshi Imanishi, and Satoshi Obika.

    Nucleic Acids Symp Ser   Vol. 53   page: 11-12   2009.9

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  31. Synthesis and properties of a novel artificial nucleoside that acts as a redox switch.

    Takeshi Baba, Tetsuya Kodama, Takeshi Imanishi, and Satoshi Obika.

    Nucleic Acids Symp Ser   Vol. 53   page: 107-108   2009.9

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  32. Synthesis of light-responsive bridged nucleic acid and changes in affinity with complementary ssRNA. Reviewed

    Kunihiko Morihiro, Tetsuya Kodama, Masaru Nishida, Takeshi Imanishi and Satoshi Obika.

    ChemBioChem   Vol. 10 ( 11 ) page: 1784-1788   2009.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cbic.200900241

  33. A bridged nucleic acid, 2',4'-BNACOC: synthesis of fully modified oligonucleotides bearing thymine, 5-methylcytosine, adenine and guanine 2',4'-BNACOC monomers, and RNA-selective nucleic acid recognition. Reviewed

    Yasunori Mitsuoka, Tetsuya Kodama, Ryo Ohnishi, Yoshiyuki Hari, Takeshi Imanishi and Satoshi Obika.

    Nucleic Acids Research   Vol. 37 ( 4 ) page: 1225-1238   2009.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/nar/gkn1062

  34. Design, synthesis, and evaluation of a novel bridged nucleic acid, 2',5'-BNAON, with S-type sugar conformation fixed by N-O linkage. Reviewed

    Tetsuya Kodama, Chieko Matsuo, Hidetsugu Ori, Tetsuya Miyoshi, Satoshi Obika, Kazuyuki Miyashita, Takeshi Imanishi.

    Tetrahedron   Vol. 65 ( 10 ) page: 2116-2123   2008.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.tet.2008.12.073

  35. Synthesis of a novel trans-3',4'-BNA monomer bearing a 4,8-dioxa-5-azabicyclo[5.3.0]decane skeleton. Reviewed

    Tetsuya Kodama, Kensaku Sugaya, Takeshi Baba, Takeshi Imanishi and Satoshi Obika.

    Heterocycles   Vol. 79 ( 1 ) page: 873-882   2008.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3987/COM-08-S(D)58

  36. Synthesis and properties of 2'-deoxy-trans-3',4'-BNA with S-type sugar puckering. Reviewed

    Tetsuya Kodama, Kensaku Sugaya, Yasuki Harada, Yasunori Mitsuoka, Takeshi Imanishi and Satoshi Obika.

    Heterocycles   Vol. 77   page: 1209-1217   2008.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3987/COM-08-S(F)99

  37. Design and Chemical Synthesis of a 2',4'-BNA Probe for 7,8-Dihydro-8-oxoguanine-containing Double Stranded DNA.

    Tetsuya Miyoshi, Tetsuya Kodama, Satoshi Obika and Takeshi Imanishi.

    Nucleic Acids Symp Ser   Vol. 52   page: 305-306   2008.9

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  38. 二リン酸ジエステル結合で連なるDNA. Reviewed

    兒玉哲也

    ファルマシア   Vol. 44 ( 1 ) page: 71-72   2008.4

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  39. Synthesis and evaluation of a novel 2',5'-bridged nucleic acid with sugar conformation fixed to S-type by N-O linkage.

    Tetsuya Kodama, Chieko Matsuo, Hidetsugu Ori, Satoshi Obika, Kazuyuki Miyashita, Takeshi Imanishi.

    Nucleic Acids Symp Ser   Vol. 51   page: 159-160   2007.11

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  40. Synthesis and properties of a 2'-deoxy analogue of trans-3',4'-BNA with an S-type sugar conformation.

    Kensaku Sugaya, Y. Harada, Yasunori Mitsuoka, Tomohisa Osaki, Satoshi Obika, Tetsuya Kodama, Takeshi Imanishi.

    Nucleic Acids Symp Ser   Vol. 51   page: 155-156   2007.11

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  41. Synthesis and chemical properties of a novel 2',4'-bridged nucleic acid analogue with a seven-membered cyclic carbamate structure.

    Masaru Nishida, Tetsuya Kodama, Satoshi Obika, Takeshi Imanishi.

    Nucleic Acids Symp Ser   Vol. 51   page: 157-158   2007.11

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  42. C5'酸化損傷DNAの有機合成とその科学的性質.

    兒玉哲也

    大阪大学低温センターだより   Vol. 138 ( 1 ) page: 18-21   2007.7

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  43. Selective detection and quantification of oxidized abasic lesions in DNA. Reviewed

    Shanta Dhar, Tetsuya Kodama, and Marc M. Greenberg.

    Journal of the American Chemical Society   Vol. 129   page: 8702-8703   2007.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/ja073014e

  44. Stable hairpins having a loop consisting of 3'-deoxy-4'-C-(2-hydroxyethyl)thymidines.

    Satoshi Shuto, Yutaka Tamura, Yuji Yamamoto, Tetsuya Kodama, Shuichi Hoshika, Satoshi Ichikawa, Yoshihito Ueno, Eiko Ohtsuka, Yasuo Komatsu, and Akira Matsuda.

    Nucleic Acids Symp Ser   Vol. 48   page: 67-68   2006.12

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  45. The first synthesis of 1'-fluoronucleosides.

    Tetsuya Kodama, Akira Matsuda and Satoshi Shuto.

    Nucleic Acids Symp Ser   Vol. 50   page: 3-4   2006.12

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  46. Synthesis of 1'-fluorouracil nucleosides as potential antimetabolites. Reviewed

    Tetsuya Kodama, Akira Matsuda and Satoshi Shuto.

    Tetrahedron   Vol. 62 ( 42 ) page: 10011-10017   2006.10

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  47. Synthesis of pyrimidine 1'-fluoronucleosides. Reviewed

    Tetsuya Kodama, Satoshi Shuto and Akira Matsuda.

    Tetrahedron Letters   Vol. 47 ( 23 ) page: 4439-4432   2006.6

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  48. Preparation and analysis of oligonucleotides containing lesions resulting from C5'-oxidation. Reviewed

    Tetsuya Kodama and Marc M. Greenberg.

    The Jounal of Organic Chemistry   Vol. 70 ( 24 ) page: 9916-9924   2005.11

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  49. Mechanistic studies on DNA damage by minor groove binding copper-phenanthroline conjugates. Reviewed

    Brian C. Bales, Tetsuya Kodama, Yvonne N. Weledji, Marguerite Pitie, Bernard Meunier and Marc M. Greenberg.

    Nucleic Aicds Research   Vol. 33 ( 16 ) page: 5371-5379   2005.9

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  50. Oligodeoxynucleotides having a loop consisting of 3'-deoxy-4'-C-(2-hydroxyethyl)thymidines form stable hairpins. Reviewed

    Yuji Yamamoto, Satoshi Shuto, Yutaka Tamura, Tetsuya Kodama, Shuichi Hoshika, Satoshi Ichikawa, Yoshihito Ueno, Eiko Ohtsuka, Yasuo Komatsu and Akira Matsuda.

    Biochemistry   Vol. 43 ( 27 ) page: 8690-8699   2004.7

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  51. Synthesis and radiacal reaction of 1'-phenylselenonucleosides.

    Tetsuya Kodama, Satoshi Shuto, Makoto Nomura and Akira Matsuda.

    Nucleic Acids Symp Ser   Vol. 44   page: 109-110   2003.8

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  52. A highly stereoselective samarium diiodide-promoted aldol reaction with l'-phenylseleno-2'-keto nucleosides. Synthesis of 1'alpha-branched uridine derivatives. Reviewed

    Tetsuya Kodama, Satoshi Shuto, Satoshi Ichikawa and Akira Matsuda.

    The Jounal of Organic Chemistry   Vol. 67 ( 22 ) page: 7706-7715   2002.11

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  53. An efficient method for the preparation of 1'alpha-branched-chain sugar pyrimidine ribonucleosides from uridine: The first conversion of a natural nucleoside into 1'-substituted ribonucleosides. Reviewed

    Tetsuya Kodama, Satoshi Shuto and Akira Matsuda.

    Chemistry-a European Journal   Vol. 7 ( 11 ) page: 2332-2340   2001.6

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  54. Synthesis of a 1'-alpha-phenylselenouridine derivative as a synthetic precursor for various 1'-modified nucleosides, via enolization at the 1'-position of 3',5'-O-TIPDS-2'-ketouridine. Reviewed

    Tetsuya Kodama, Satoshi Shuto, Makoto Nomura and Akira Matsuda.

    Tetrahedron Letters   Vol. 41 ( 19 ) page: 3643-3646   2000.5

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Presentations 32

  1. 糖部構造を刷新した人工核酸の設計と合成

    兒玉 哲也

    第2回 BINDS 合成勉強会 

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    Event date: 2019.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北海道大学(北海道)   Country:Japan  

  2. 歪んだトランス縮環骨格を糖部骨格とするヌクレオシド類の合成

    兒玉 哲也, 牧野 亜衣, 近田 達哉, 中野 篤志, 大石 和馬, 廣明 秀一

    第113回有機合成シンポジウム2018年 

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    Event date: 2018.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:名古屋(愛知)   Country:Japan  

  3. Syntheitc study of an N3'->P5' phosphoramidate-type nucleic acid

    Tatsuya Konda, Hidekazu Hiroaki, Tetsuya Kodama

    The 44th International Symposium on Nucleic Acids Chemistry 2017, The 1st Annual Meeting of Japan Society of Nucleic Acids Chemistry 

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    Event date: 2017.11

    Language:English   Presentation type:Poster presentation  

    Venue:Tokyo University of Science Katsushika Campus Library Hall (Katsushika, Tokyo)   Country:Japan  

  4. 二面角ガンマを固定した 2ʼ-5ʼ 連結型核酸分子含有オリゴ核酸の合成とその二重鎖、三重鎖核酸の安定性

    牧野亜衣, 廣明秀一, 兒玉哲也

    日本核酸医薬学会 第2回年会 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京理科大学葛飾キャンパス図書館ホール(東京)   Country:Japan  

  5. オリゴ核酸の創薬研究:化学者の立場からみる問題点とその解決に向けた試み Invited International conference

    兒玉哲也

    第 2 回名古屋大学-ラクオリア創薬シンポジウム 

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    Event date: 2016.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:名古屋大学(名古屋市)   Country:Japan  

  6. セレノメチレン架橋型ピリミジンヌクレオシドで修飾したアンチセンス分子

    兒玉哲也, 百相義大, 森廣邦彦, 廣明秀一, 小比賀 聡

    日本核酸医薬学会第1回年会 

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    Event date: 2015.11 - 2015.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都テルサ(京都市)   Country:Japan  

  7. 核酸塩基の回転を制限したチミジン誘導体の合成研究

    兒玉哲也, 守屋彩子, 廣明秀一

    第44回複素環化学討論会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:北海道(札幌市民ホール)   Country:Japan  

    核酸塩基の回転角と高次構造安定性との間の関係を調べるため、塩基部と糖部との間を共有結合でつなぐ事でその回転を制限したチミジンアナログを設計し、その合成を検討した。

  8. 核酸医薬への応用を志向した人工核酸の設計と合成、天然核酸との相違

    兒玉哲也

    新学術領域研究「天然物ケミカルバイオロジー~分子標的と活性制御~」第5回若手研究者ワークショップ 

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    Event date: 2014.5

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  9. 架橋型人工核酸(BNA)の核酸医薬への応用

    兒玉哲也

    名古屋大学 予防早期医療創成センター 第4回ワークショップ 

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    Event date: 2014.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  10. ヌクレオシド・ヌクレオチドならびにオリゴヌクレオチドのメディシナルケミストリー

    兒玉哲也

    中部地区 医療・バイオ系シーズ発表会 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:愛知(ウインクあいち)   Country:Japan  

  11. 核酸化学: 核酸医薬創出に向けた 新たなコンホメーション固定型人工核酸の開発

    兒玉哲也

    第2回岐阜構造生物学・医学・論理的創薬研究会シンポジウム 

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    Event date: 2013.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:岐阜大学   Country:Japan  

  12. Torsion angle around glycosidic bond on BNA/LNA-purine strongly affects duplex stability

    Tetsuya Kodama, Takashi Hara, Yumi Takegaki, Kunihiro Morihiro, Kosuke R. Ito, Satoshi Obika

    The 39th International Symposium on Nucleic Acids Chemistry 

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    Event date: 2012.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  13. チミン塩基をもつセレノメチレン架橋型人工核酸の合成と基本的性質

    兒玉哲也,森廣邦彦,肯特夫,百相義大,Rakesh N. Veedu,小比賀聡

    アンチセンス・遺伝子・デリバリーシンポジウム 2012 

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    Event date: 2012.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:宮城(仙台市民会館)   Country:Japan  

  14. 糖部構造を固定化したグルコピラノシル核酸の合成と構造に関する研究 International conference

    兒玉哲也, 森和土, 小比賀聡

    第58回 日本薬学会東海支部大会 

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    Event date: 2012.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:静岡(静岡県立大学)   Country:Japan  

  15. 有機化学からみた核酸化学:設計と合成、そして基本的性質

    兒玉哲也

    創薬基盤化学研究若手セミナー 

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    Event date: 2012.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:滋賀県草津市(立命館大学)   Country:Japan  

  16. A new entry of thiol-containing nucleic acid monomer for conjugation chemistry. International conference

    Tetsuya Kodama, Kazuto Mori, Takeshi Baba and Satoshi Obika

    6th Cambridge Symposium on Nucleic Acids Chemistry and Biology 

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    Event date: 2011.9

    Language:English   Presentation type:Poster presentation  

    Country:United Kingdom  

  17. An additional chemical modification of 2',4'-BNA/LNA oligonucleotides: Effect of amino modifiers on phosphate backbone International conference

    Tetsuya Kodama, S. M. Abdur Rahman, Takeshi Baba, Kazuto Mori, Satoshi Obika

    The International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) 

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    Event date: 2010.12

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  18. 外部刺激応答性架橋型人工核酸スイッチの開発

    兒玉哲也, 森廣邦彦, 馬場武, 今西武, 小比賀聡

    第60回 日本薬学会近畿支部大会 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:摂南大学、大阪  

  19. 遺伝子発現の時空間制御を目指した外部刺激応答型人工核酸スイッチの設計と合成

    兒玉哲也, 馬場武, 森廣邦彦, 今西武, 小比賀聡

    第59回 日本薬学会近畿支部大会 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:近畿大学、大阪  

  20. 次世代核酸系素材の創製を目指した高度機能化人工核酸の設計と合成

    兒玉哲也

    第33回大学分析者の会 

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    Event date: 2009.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:大阪大学、大阪  

  21. 3-オキサ-4-アザペンチレン架橋構造を有する新しい trans-3’,4’-BNA の設計と合成

    兒玉 哲也、菅谷 建作、馬場 武、今西 武、小比賀 聡

    日本薬学会第129年会 

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    Event date: 2009.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都  

  22. 二重鎖DNA中の8-オキソグアニン塩基を選択的に認識する人工核酸プローブ

    兒玉哲也

    第11回生命化学研究会 

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    Event date: 2008.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:水上、群馬  

  23. 8-OxoGの配列特異的認識能を有する三重鎖形成人工核酸の開発 (2)

    兒玉 哲也,三好 哲也,小比賀 聡,今西 武

    第58回 日本薬学会近畿支部大会 

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    Event date: 2008.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸薬科大学、兵庫  

  24. DNA 配列選択的な 8-ヒドロキシグアニン検出プローブの創製研究

    兒玉 哲也、三好 哲也、小比賀 聡、今西 武

    第6回次世代を担う有機化学シンポジウム 

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    Event date: 2008.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京  

  25. Synthesis and chemical properties of a novel 2',4'-bridged nucleic acid analogue with a seven-membered cyclic carbamate structure.

    Tetsuya Kodama,Chieko Matsuo,Hidetsugu Ori,Satoshi Obika,Kazuyuki Miyashita,and Takeshi Imanishi

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    Event date: 2007.11

    Language:English   Presentation type:Poster presentation  

  26. N-O結合により糖部コンホメーションをS型に固定化した新しい2’,5’-架橋型人工核酸の合成と機能生評価

    兒玉 哲也、松尾 智恵子、小里 英嗣、小比賀 聡、宮下 和之、今西 武

    第57回日本薬学会 近畿支部大会 

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    Event date: 2007.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪薬科大学、大阪  

  27. 1’-フルオロヌクレオシドの合成研究

    兒玉哲也、周東智、松田彰

    日本薬学会第122年会 

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    Event date: 2002.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:千葉  

  28. ヨウ化サマリウムによる1’-エノラートの生成とそのアルドール反応

    兒玉哲也、周東智、市川聡、松田彰

    日本薬学会第121年会 

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    Event date: 2001.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:北海道  

  29. ウリジン1’-サマリウムエノラートのアルドール反応を鍵反応とした1’-修飾ウリジンの合成研究

    兒玉哲也、周東智、市川聡、松田彰

    第117回日本薬学会北海道支部例会 

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    Event date: 2001.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北海道  

  30. 1’-フェニルセレニルヌクレオシドの合成とラジカル反応

    兒玉哲也、野村誠、周東智、松田彰

    第27回核酸化学シンポジウム 

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    Event date: 2000.10 - 2000.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山  

  31. 1’alpha-修飾ピリミジンヌクレオシドの合成研究

    兒玉哲也、野村誠、周東智、松田彰

    日本薬学会第120年会 

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    Event date: 2000.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:岐阜  

  32. ヌクレオシド1’-位へのフェニルセレニル基の導入とラジカル反応への応用: 1’-分枝糖ヌクレオシドの合成

    兒玉哲也、野村誠、周東智、松田彰

    第112回日本薬学会北海道支部例会 

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    Event date: 1999.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北海道  

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Research Project for Joint Research, Competitive Funding, etc. 1

  1. デリバリーと安全性を融合した新世代核酸医薬プラットフォームの構築

    2019.10

    AMED  先端的バイオ創薬等基盤技術開発事業 

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    Authorship:Coinvestigator(s)  Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. 生体安定性と毒性低減とを志向した、糖部とリン酸部の構造制御による人工核酸設計

    2017.4 - 2019.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  2. 次世代核酸医薬の開発を志向した三重鎖形成核酸創製基盤の構築

    2014.4 - 2017.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  3. 核酸塩基の回転角制御に基づく人工核酸創製法に関する研究

    2012.4 - 2014.3

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

  4. 化学的なシトシン塩基メチル化法の開発

    2010.4 - 2012.3

    科学研究費補助金 

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    Authorship:Principal investigator 

  5. 遺伝子損傷の非侵襲的視覚化を目指した遺伝子配列特異的損傷塩基検出プローブの創製

    2008.4 - 2010.3

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

  6. DNA配列特異的な8-ヒドロキシグアニンの認識;生きたDNA酸化損傷情報の視覚化

    2006.4 - 2008.3

    科学研究費補助金 

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    Authorship:Principal investigator 

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Teaching Experience (On-campus) 70

  1. 先端構造科学

    2019

  2. 創薬分子構造学セミナーⅠA

    2019

  3. 創薬分子構造学セミナーⅠB

    2019

  4. 創薬分子構造学実験

    2019

  5. 基盤創薬学概論

    2019

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    核酸の立体構造の基礎と熱的安定性と生理活性発現機構

  6. 基礎生物物理学Ib

    2019

  7. 多分野融合実践実習

    2019

  8. 多分野融合実践演習

    2019

  9. 生物学基礎II

    2019

  10. 先端構造科学

    2018

  11. 創薬分子構造学セミナーⅠA

    2018

  12. 創薬分子構造学セミナーⅠB

    2018

  13. 創薬分子構造学実験

    2018

  14. 基盤創薬学概論

    2018

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    核酸の立体構造の基礎と熱的安定性と生理活性発現機構

  15. 基礎生物物理学Ib

    2018

  16. 多分野融合実践実習

    2018

  17. 多分野融合実践演習

    2018

  18. 生物学基礎II

    2018

  19. 創薬分子構造学実験

    2017

  20. 基盤創薬学概論

    2017

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    核酸の立体構造の基礎と熱的安定性と生理活性発現機構

  21. 基礎生物物理学1

    2017

  22. 多分野融合実践実習

    2017

  23. 多分野融合実践演習

    2017

  24. 生物学基礎II

    2017

  25. 創薬分子構造学セミナーⅠA

    2017

  26. 先端構造科学

    2017

  27. 創薬分子構造学セミナーⅠB

    2017

  28. 先端構造科学

    2016

  29. 創薬分子構造学セミナーⅠA

    2016

  30. 創薬分子構造学セミナーⅠB

    2016

  31. 創薬分子構造学実験

    2016

  32. 基盤創薬学概論

    2016

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    核酸の立体構造の基礎と熱的安定性と生理活性発現機構

  33. 基礎生物物理学1

    2016

  34. 多分野融合実践実習

    2016

  35. 多分野融合実践演習

    2016

  36. 生物学基礎II

    2016

  37. 創薬分子構造学実験

    2015

  38. 創薬分子構造学セミナーⅠB

    2015

  39. 創薬分子構造学セミナーⅠA

    2015

  40. 先端構造科学

    2015

  41. 生物学基礎II

    2015

  42. 多分野融合実践演習

    2015

  43. 多分野融合実践実習

    2015

  44. 基礎生物物理学1

    2015

  45. 基盤創薬学概論

    2015

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    核酸の立体構造の基礎と熱的安定性と生理活性発現機構

  46. 生物学基礎II

    2014

  47. Basic Training for Crossover Research

    2014

  48. Basic Experiment for Crossover Research

    2014

  49. 基礎生物物理学1

    2014

  50. 基盤創薬学概論

    2014

  51. Structural Biology Research Course

    2014

  52. Seminar in Structural Biology ⅠB

    2014

  53. Seminar in Structural Biology ⅠA

    2014

  54. 先端構造科学

    2014

  55. Basic Training for Crossover Research

    2013

  56. Basic Experiment for Crossover Research

    2013

  57. Structural Biology Research Course

    2013

  58. Seminar in Structural Biology ⅠB

    2013

  59. Seminar in Structural Biology ⅠA

    2013

  60. 先端構造科学

    2013

  61. 基礎セミナー

    2013

  62. 基盤創薬学概論

    2013

  63. 基礎生物物理学1

    2013

  64. Introduction to Pharmaceutical Sciences

    2012

  65. Structural Biology Research Course

    2012

  66. Seminar in Structural Biology ⅠB

    2012

  67. Seminar in Structural Biology ⅠA

    2012

  68. Advanced Structural Biophysics

    2012

  69. Basic Experiment for Crossover Research

    2012

  70. Basic Training for Crossover Research

    2012

▼display all

 

Social Contribution 3

  1. スーパーサイエンスハイスクール

    Role(s):Lecturer, Demonstrator

    名古屋市立向陽高等学校  KGS 連携:KGS 研究室体験  創薬科学研究館・構造分子薬理学分野  2019.8

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    Audience: High school students

    Type:Other

    「医薬品に関連したヌクレオシドの合成と分析」と題し、(1)医薬品の分類と定義、身の回りの医薬品の成分について概説し、続いて次世代医薬品の一つ核酸医薬を紹介した。さらに、(2)核酸医薬で実際に用いられる 5-メチルシチジンの化学合成とNMRや分光光度計を用いた分析を体験してもらった。

  2. スーパーサイエンスハイスクール

    Role(s):Lecturer, Demonstrator

    名古屋市立向陽高等学校  KGS 連携:KGS 研究室体験  創薬科学館・構造分子薬理学分野  2018.8

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    Audience: High school students

    Type:Other

    「医薬品に関連したヌクレオシドの合成と分析」と題し、(1)医薬品の分類と定義、身の回りの医薬品の成分について概説し、続いて次世代医薬品の一つ核酸医薬を紹介した。さらに、(2)核酸医薬で実際に用いられる 5-メチルシチジンの化学合成とNMRや分光光度計を用いた分析を体験してもらった。

  3. ファルマシアトピックス専門小委員

    2011.4 - 2014.3

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    日本薬学会会誌ファルマシアのトピックス編集