Updated on 2021/11/02

写真a

 
TATSUKAWA Hideki
 
Organization
Graduate School of Pharmaceutical Sciences Department of Basic Medicinal Sciences Bioscience Assistant Professor
Graduate School
Graduate School of Pharmaceutical Sciences
Undergraduate School
School of Agricultural Sciences
Title
Assistant Professor
Contact information
メールアドレス
External link

Degree 3

  1. 博士(医学) ( 2009.3   東京医科歯科大学 ) 

  2. 修士(医科学) ( 2005.3   東京医科歯科大学 ) 

  3. 学士(理学) ( 2003.3   東京理科大学 ) 

Research Interests 9

  1. 生物系薬学

  2. ケミカルバイオロジー.薬理学一般

  3. 消化器内科学

  4. 分子生物学

  5. 農芸化学

  6. 生物系薬学

  7. 生化学

  8. 消化器内科学

  9. ケミカルバイオロジー.薬理学一般

Research Areas 4

  1. Others / Others  / Cellular Biochemistry

  2. Life Science / Cell biology

  3. Life Science / Pathological biochemistry

  4. Life Science / Applied molecular and cellular biology

Current Research Project and SDGs 6

  1. 肝線維化の病態機序の解明

  2. 腎線維化の病態機序の解明

  3. FRETを用いたタンパク質架橋化酵素活性の生体内検出プローブの開発

  4. タンパク質架橋化酵素の網羅的な生体内発現分布の解析

  5. 非環式レチノイドによる肝臓癌特異的細胞死の経路解析に基づく新規抗癌剤の開発

  6. Role of Transglutaminase 2 in Liver Injury via Crosslinking and Silencing of Transcription Factor, Sp1

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Research History 2

  1. Nagoya University   School of Agricultural Sciences

    2012.4

  2. 理化学研究所 特別研究員

    2009.4 - 2012.3

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    Country:Japan

Education 3

  1. Tokyo Medical and Dental University   Graduate School of Medical and Dental Sciences   Gerontology and Gerodontology

    2005.4 - 2009.3

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    Country: Japan

  2. Tokyo Medical and Dental University   Graduate School of Medical and Dental Sciences   Gerontology and Gerodontology

    2003.4 - 2005.3

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    Country: Japan

  3. Tokyo University of Science   Faculty of Science   Department of Chemistry

    1999.4 - 2003.3

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    Country: Japan

Professional Memberships 13

  1. 日本分子生物学会

    2003

  2. 日本生化学会

  3. 日本農芸化学会

  4. 日本肝臓学会

  5. 日本生化学会

    2003

  6. 日本癌学会

  7. ケミカルバイオロジー学会

  8. American Thoracic Society

  9. 日本腎臓学会

  10. 日本肝臓学会

  11. 日本癌学会

  12. 日本免疫学会

  13. ケミカルバイオロジー学会

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Committee Memberships 2

  1. Nature Research Publishing - Scientific reports -   Editorial board member  

    2019.6   

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    Committee type:Academic society

  2. 日本生化学会 中部支部   幹事  

    2017.9 - 2019.8   

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    Committee type:Academic society

Awards 8

  1. Young Investigator Travel Award

    2018.9   International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis  

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    Award type:Award from international society, conference, symposium, etc.  Country:Japan

  2. Young Investigator award

    2018.9   The 13th International Symposium on ALPD and Cirrhosis  

  3. Travel Award

    2011.10   International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis  

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    Country:Japan

  4. CHUGAI Award

    2010.10  

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    Country:Japan

  5. Travel Award

    2009.10   International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis  

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    Country:Japan

  6. Poster Award

    2009.10  

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    Country:Japan

  7. Best Poster Award

    2009.10  

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    Country:Japan

  8. Travel Award

    2007.10   International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis  

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    Country:Japan

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Papers 63

  1. Investigation of mouse amniotic fluid for stimulating ability of keratinocyte differentiation depending on the fetal stage.

    Kuribayashi M, Kawaguchi Y, Teshima H, Yamaguchi H, Tatsukawa H, Hitomi K

    Archives of biochemistry and biophysics   Vol. 711   page: 109003   2021.10

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    DOI: 10.1016/j.abb.2021.109003

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  2. Spatially Resolved Identification of Transglutaminase Substrates by Proteomics in Pulmonary Fibrosis

    Takeuchi Taishu, Tatsukawa Hideki, Shinoda Yoshiki, Kuwata Keiko, Nishiga Miyuki, Takahashi Hiroshi, Hase Naoki, Hitomi Kiyotaka

    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY   Vol. 65 ( 3 ) page: 319 - 330   2021.9

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  3. Role of Transglutaminase 2 in Cell Death, Survival, and Fibrosis

    Tatsukawa Hideki, Hitomi Kiyotaka

    CELLS   Vol. 10 ( 7 )   2021.7

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  4. タンパク質架橋化酵素トランスグルタミナーゼの糸球体炎症進展への役割解明

    伊藤 辰将, 辰川 英樹, 梅田 良祐, 横江 優貴, 高橋 和男, 湯澤 由紀夫, 人見 清隆, 坪井 直毅

    日本腎臓学会誌   Vol. 63 ( 4 ) page: 519 - 519   2021.6

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    Language:Japanese   Publisher:(一社)日本腎臓学会  

  5. Thrombin-deficient mutant of medaka, a model fish, displays serious retardation in blood coagulation

    Watanabe Yuko, Oguri Rina, Suzuki Risa, Meng Qi, Ishikawa Yuta, Tatsukawa Hideki, Hashimoto Hisashi, Hitomi Kiyotaka

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   Vol. 85 ( 4 ) page: 824 - 833   2021.3

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  6. Thrombin-deficient mutant of medaka, a model fish, displays serious retardation in blood coagulation. Reviewed

    doi: 10.1093/bbb/zbaa098.

    Biosci Biotechnol Biochem     2021.2

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    Language:English  

    DOI: 10.1093/bbb/zbaa098.

  7. Identification and characterization of substrates crosslinked by transglutaminases in liver and kidney fibrosis. Reviewed

    Tatsukawa H, Takeuchi T, Shinoda Y, Hitomi K

    Analytical biochemistry   Vol. 604   page: 113629   2020.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ab.2020.113629

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  8. Transglutaminase orthologues for medaka fish research model- biochemical characterization and establishment of gene-deficient mutants. Reviewed

    Meng Q, Watanabe Y, Suzuki R, Oguri R, Tatsukawa H, Hitomi K

    Analytical biochemistry   Vol. 604   page: 113610   2020.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ab.2020.113610

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  9. Gene disruption of medaka (Oryzias latipes) orthologue for mammalian tissue-type transglutaminase (TG2) causes movement retardation. Reviewed

    Watanabe Y, Okuya K, Takada Y, Kinoshita M, Yokoi S, Chisada S, Kamei Y, Tatsukawa H, Yamamoto N, Abe H, Hashimoto H, Hitomi K

    Journal of biochemistry   Vol. 168 ( 3 ) page: 213 - 222   2020.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jb/mvaa038

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  10. Analysis of the expression of transglutaminases in the reconstructed human epidermis using three-dimensional cell culture. Reviewed

    Teshima H, Kato M, Tatsukawa H, Hitomi K

    Analytical biochemistry   Vol. 603   page: 113606   2020.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ab.2020.113606

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  11. 抗体型糸球体腎炎におけるタンパク質架橋化酵素トランスグルタミナーゼの機能

    伊藤 辰将, 辰川 英樹, 横江 優貴, 高橋 和男, 丸山 彰一, 湯澤 由紀夫, 人見 清隆, 坪井 直毅

    日本腎臓学会誌   Vol. 62 ( 4 ) page: 270 - 270   2020.7

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  12. タンパク質架橋酵素を介した上皮細胞の間葉転換機構の解析

    辰川英樹, 篠田祥希, 竹内大修, 人見清隆

      Vol. 55   page: 1 - 9   2020.3

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    Authorship:Lead author, Corresponding author  

  13. Studies on differentiation-dependent expression and activity of distinct transglutaminases by specific substrate peptides using three-dimensional reconstituted epidermis

    Tanabe Yuki, Yamane Miki, Kato Manami, Teshima Hirofumi, Kuribayashi Miki, Tatsukawa Hideki, Takama Hiroyuki, Akiyama Masashi, Hitomi Kiyotaka

    FEBS JOURNAL   Vol. 286 ( 13 ) page: 2536 - 2548   2019.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/febs.14832

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  14. Detection and identification of potential transglutaminase 2 substrates in the mouse renal glomeruli.

    Ito Y, Tatsukawa H, Yamaguchi H, Takahashi K, Hitomi K, Yuzawa Y

    Archives of biochemistry and biophysics   Vol. 660   page: 11 - 19   2018.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.abb.2018.10.001

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  15. Tschimganine and its derivatives extend the chronological life span of yeast via activation of the Sty1 pathway

    Hibi Takahide, Ohtsuka Hokuto, Shimasaki Takafumi, Inui Shougo, Shibuya Masatoshi, Tatsukawa Hideki, Kanie Kei, Yamamoto Yoshihiko, Aiba Hirofumi

    GENES TO CELLS   Vol. 23 ( 8 ) page: 620 - 637   2018.8

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    DOI: 10.1111/gtc.12604

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  16. Targeting transglutaminase 2 partially restores extracellular matrix structure but not alveolar architecture in experimental bronchopulmonary dysplasia.

    The FEBS journal   Vol. 285 ( 16 ) page: 3056 - 3076   2018.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/febs.14596

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  17. ISOZYME-SPECIFIC IDENTIFICATION AND CHARACTERIZATION OF SUBSTRATES CROSSLINKED BY TRANSGLUTAMINASES IN LIVER FIBROSIS

    Tatsukawa H., Nakagawa H., Hitomi K.

    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH   Vol. 42   page: 33A-33A   2018.8

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  18. Isozyme-specific comprehensive characterization of transglutaminase-crosslinked substrates in kidney fibrosis

    Tatsukawa Hideki, Otsu Risa, Tani Yuji, Wakita Ryosuke, Hitomi Kiyotaka

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 7306   2018.5

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    DOI: 10.1038/s41598-018-25674-4

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  19. Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid

    Qin Xian-Yang, Suzuki Harukazu, Honda Masao, Okada Hikari, Kaneko Shuichi, Inoue Ikuyo, Ebisui Etsuko, Hashimoto Kosuke, Carninci Piero, Kanki Keita, Tatsukawa Hideki, Ishibashi Naoto, Masaki Takahiro, Matsuura Tomokazu, Kagechika Hiroyuki, Toriguchi Kan, Hatano Etsuro, Shirakami Yohei, Shiota Goshi, Shimizu Masahito, Moriwaki Hisataka, Kojima Soichi

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   Vol. 115 ( 19 ) page: 4969 - 4974   2018.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.1802279115

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  20. 糖尿病モデルマウスにおけるキヌレニン経路代謝物の腎組織イメージング質量分析

    松下 祥子, 高橋 和男, 伊藤 辰将, 山本 康子, 藤垣 英嗣, 毛利 彰宏, 中嶋 和紀, 尾之内 高慶, 辰川 英樹, 釘田 雅則, 長尾 静子, 人見 清隆, 齋藤 邦明, 瀬藤 光利, 湯澤 由紀夫

    日本腎臓学会誌   Vol. 60 ( 3 ) page: 403 - 403   2018.4

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  21. 組織の線維化に伴い架橋される基質タンパク質群の網羅的同定・解析 Invited

    辰川英樹, 人見清隆

    日本応用酵素協会   Vol. 52   page: 1-10   2018.3

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  22. Higher susceptibility to osmolality of the medaka (Oryzias latipes) mutants in orthologue genes of mammalian skin transglutaminases

    Watanabe Yuko, Furukawa Eri, Tatsukawa Hideki, Hashimoto Hisashi, Kamei Yasuhiro, Taniguchi Yoshihito, Hitomi Kiyotaka

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   Vol. 82 ( 7 ) page: 1165 - 1168   2018

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    DOI: 10.1080/09168451.2018.1453294

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  23. Global identification and analysis of isozyme-specific substrates crosslinked by transglutaminases in mouse liver fibrosis

    Tatsukawa Hideki, Nakagawa Haruka, Kiyotaka Hitomi

    HEPATOLOGY   Vol. 66   page: 222A-222A   2017.10

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  24. Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes Reviewed

    Qin Xian-Yang, Hara Mitsuko, Arner Erik, Kawaguchi Yoshikuni, Inoue Ikuyo, Tatsukawa Hideki, Furutani Yutaka, Nagatsuma Keisuke, Matsuura Tomokazu, Wei Feifei, Kikuchi Jun, Sone Hideko, Daub Carsten, Kawaji Hideya, Lassmann Timo, Itoh Masayoshi, Suzuki Harukazu, Carninci Piero, Hayashizaki Yoshihide, Kokudo Norihiro, Forrest Alistair R. R., Kojima Soichi

    EBIOMEDICINE   Vol. 24   page: 257 - 266   2017.10

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    DOI: 10.1016/j.ebiom.2017.09.008

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  25. Biochemical characterization of a medaka (Oryzias latipes) orthologue for mammalian Factor XIII and establishment of a gene-edited mutant

    Horimizu Rima, Ogawa Ryota, Watanabe Yuko, Tatsukawa Hideki, Kinoshita Masato, Hashimoto Hisashi, Hitomi Kiyotaka

    FEBS JOURNAL   Vol. 284 ( 17 ) page: 2843 - 2855   2017.9

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    DOI: 10.1111/febs.14153

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  26. Data Descriptor: FANTOM5 CAGE profiles of human and mouse samples

    Noguchi Shuhei, Arakawa Takahiro, Fukuda Shiro, Furuno Masaaki, Hasegawa Akira, Hori Fumi, Ishikawa-Kato Sachi, Kaida Kaoru, Kaiho Ai, Kanamori-Katayama Mutsumi, Kawashima Tsugumi, Kojima Miki, Kubosaki Atsutaka, Manabe Ri-ichiroh, Murata Mitsuyoshi, Nagao-Sato Sayaka, Nakazato Kenichi, Ninomiya Noriko, Nishiyori-Sueki Hiromi, Noma Shohei, Saijyo Eri, Saka Akiko, Sakai Mizuho, Simon Christophe, Suzuki Naoko, Tagami Michihira, Watanabe Shoko, Yoshida Shigehiro, Arner Peter, Axton Richard A., Babina Magda, Baillie J. Kenneth, Barnett Timothy C., Beckhouse Anthony G., Blumenthal Antje, Bodega Beatrice, Bonetti Alessandro, Briggs James, Brombacher Frank, Carlisle Ailsa J., Clevers Hans C., Davis Carrie A., Detmar Michael, Dohi Taeko, Edge Albert S. B., Edinger Matthias, Ehrlund Anna, Ekwall Karl, Endoh Mitsuhiro, Enomoto Hideki, Eslami Afsaneh, Fagiolini Michela, Fairbairn Lynsey, Farach-Carson Mary C., Faulkner Geoffrey J., Ferrai Carmelo, Fisher Malcolm E., Forrester Lesley M., Fujita Rie, Furusawa Jun-ichi, Geijtenbeek Teunis B., Gingeras Thomas, Goldowitz Daniel, Guhl Sven, Guler Reto, Gustincich Stefano, Ha Thomas J., Hamaguchi Masahide, Hara Mitsuko, Hasegawa Yuki, Herlyn Meenhard, Heutink Peter, Hitchens Kelly J., Hume David A., Ikawa Tomokatsu, Ishizu Yuri, Kai Chieko, Kawamoto Hiroshi, Kawamura Yuki I., Kempfle Judith S., Kenna Tony J., Kere Juha, Khachigian Levon M., Kitamura Toshio, Klein Sarah, Klinken S. Peter, Knox Alan J., Kojima Soichi, Koseki Haruhiko, Koyasu Shigeo, Lee Weonju, Lennartsson Andreas, Mackay-sim Alan, Mejhert Niklas, Mizuno Yosuke, Morikawa Hiromasa, Morimoto Mitsuru, Moro Kazuyo, Morris Kelly J., Motohashi Hozumi, Mummery Christine L., Nakachi Yutaka, Nakahara Fumio, Nakamura Toshiyuki, Nakamura Yukio, Nozaki Tadasuke, Ogishima Soichi, Ohkura Naganari, Ohno Hiroshi, Ohshima Mitsuhiro, Okada-Hatakeyama Mariko, Okazaki Yasushi, Orlando Valerio, Ovchinnikov Dmitry A., Passier Robert, Patrikakis Margaret, Pombo Ana, Pradhan-Bhatt Swati, Qin Xian-Yang, Rehli Michael, Rizzu Patrizia, Roy Sugata, Sajantila Antti, Sakaguchi Shimon, Sato Hiroki, Satoh Hironori, Savvi Suzana, Saxena Alka, Schmidl Christian, Schneider Claudio, Schulze-Tanzil Gundula G., Schwegmann Anita, Sheng Guojun, Shin Jay W., Sugiyama Daisuke, Sugiyama Takaaki, Summers Kim M., Takahashi Naoko, Takai Jun, Tanaka Hiroshi, Tatsukawa Hideki, Tomoiu Andru, Toyoda Hiroo, van de Wetering Marc, van den Berg Linda M., Verardo Roberto, Vijayan Dipti, Wells Christine A., Winteringham Louise N., Wolvetang Ernst, Yamaguchi Yoko, Yamamoto Masayuki, Yanagi-Mizuochi Chiyo, Yoneda Misako, Yonekura Yohei, Zhang Peter G., Zucchelli Silvia, Abugessaisa Imad, Arner Erik, Harshbarger Jayson, Kondo Atsushi, Lassmann Timo, Lizio Marina, Sahin Serkan, Sengstag Thierry, Severin Jessica, Shimoji Hisashi, Suzuki Masanori, Suzuki Harukazu, Kawai Jun, Kondo Naoto, Itoh Masayoshi, Daub Carsten O., Kasukawa Takeya, Kawaji Hideya, Carninci Piero, Forrest Alistair R. R., Hayashizaki Yoshihide

    SCIENTIFIC DATA   Vol. 4   page: 170112   2017.8

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    DOI: 10.1038/sdata.2017.112

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  27. Global identification and analysis of isozyme-specific possible substrates crosslinked by transglutaminases using substrate peptides in mouse liver fibrosis Reviewed

    Tatsukawa Hideki, Tani Yuji, Otsu Risa, Nakagawa Haruka, Hitomi Kiyotaka

    SCIENTIFIC REPORTS   Vol. 7   page: 45049   2017.3

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    DOI: 10.1038/srep45049

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  28. FRET-based detection of isozyme-specific activities of transglutaminases. Reviewed

    Tatsukawa H, Liu HH, Oba S, Kamiya N, Nakanishi Y, Hitomi K.

    Amino Acids   Vol. 49 ( 3 ) page: 615-623   2017.3

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00726-016-2322-0.

  29. FRET-based detection of isozyme-specific activities of transglutaminases

    Tatsukawa Hideki, Liu Hong Hong, Oba Shota, Kamiya Noriho, Nakanishi Yoichi, Hitomi Kiyotaka

    AMINO ACIDS   Vol. 49 ( 3 ) page: 615 - 623   2017.3

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    DOI: 10.1007/s00726-016-2322-0

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  30. Biochemical characterization of the medaka (Oryzias latipes) orthologue for mammalian tissue-type transglutaminase (TG2)

    Takada Yuki, Watanabe Yuko, Okuya Kazuho, Tatsukawa Hideki, Hashimoto Hisashi, Hitomi Kiyotaka

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   Vol. 81 ( 3 ) page: 469 - 474   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/09168451.2016.1256757

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  31. Analysis on transglutaminase 1 and its substrates using specific substrate peptide in cultured keratinocytes.

    Yamane M, Sugimura K, Kawasaki H, Tatsukawa H, Hitomi K.

    Biochem Biophys Res Commun   Vol. 478 ( 1 ) page: 343-348   2016.9

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    DOI: 10.1016/j.bbrc.2016.07.051.

  32. Transglutaminase 2 has opposing roles in the regulation of cellular functions as well as cell growth and death.

    Tatsukawa H, Furutani Y, Hitomi K, Kojima S.

    Cell Death and Disease   Vol. 7 ( 6 ) page: e2244   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/cddis.2016.150.

  33. Metabolome Analyses Uncovered a Novel Inhibitory Effect of Acyclic Retinoid on Aberrant Lipogenesis in a Mouse Diethylnitrosamine-Induced Hepatic Tumorigenesis Model.

    Qin XY, Tatsukawa H, Hitomi K, Shirakami Y, Ishibashi N, Shimizu M, Moriwaki H, Kojima S.

    Cancer Prevention Research     2016.3

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    DOI: 10.1158/1940-6207.CAPR-15-0326.

  34. Biochemical Characterization of Medaka (Oryzias latipes) Transglutaminases, OlTGK1 and OlTGK2, as Orthologues of Human Keratinocyte-Type Transglutaminase.

    Kikuta A, Furukawa E, Ogawa R, Suganuma N, Saitoh M, Nishimaki T, Katsumura T, Oota H, Kawamoto T, Tatsukawa H, Hashimoto H, Hitomi K.

    PLoS One     2015.12

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    DOI: doi: 10.1371/journal.pone.0144194.

  35. The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome.

    Hurst LD, Ghanbarian AT, Forrest AR; FANTOM consortium (Tatsukawa H), Huminiecki L.

    PLoS Biology     2015.12

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    DOI: doi: 10.1371/journal.pbio.1002315.

  36. Application of Gene Expression Trajectories Initiated from ErbB Receptor Activation Highlights the Dynamics of Divergent Promoter Usage.

    Carbajo D, Magi S, Itoh M, Kawaji H, Lassmann T, Arner E, Forrest AR, Carninci P, Hayashizaki Y, Daub CO; FANTOM consortium (Tatsukawa H), Okada-Hatakeyama M, Mar JC.

    PLoS One     2015.12

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    DOI: doi: 10.1371/journal.pone.0144176.

  37. Molecular mechanism by which acyclic retinoid induces nuclear localization of transglutaminase 2 in human hepatocellular carcinoma cells. Reviewed

    Shrestha R, Tatsukawa H, Shrestha R, Ishibashi N, Matsuura T, Kagechika H, Kose S, Hitomi K, Imamoto N, Kojima S.

    Cell Death & Disease     2015.12

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    DOI: doi: 10.1038/cddis.2015.339.

  38. Distribution of transglutaminase family members in mouse whole body sections. Reviewed

    Tatsukawa H, Abe N, Ohashi S, Hitomi K

    Biochem Biophys Res Commun     2015.10

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    DOI: 10.1016/j.bbrc.2015.10.001.

  39. Early response as shown by enhancement of transglutaminase 1 expression after cisplatin-induced acute kidney injury Reviewed

    Furukawa K, Yamane M, Tatsukawa H, Hitomi K

    Arch Biochem Biophys   Vol. 586   page: 27-32   2015.9

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  40. Discovery of molecular markers to discriminate corneal endothelial cells in the human body Reviewed

    Yoshihara M, Ohmiya H, Hara S, Kawasaki S; FANTOM consortium (Tatsukawa H), Hayashizaki Y, Itoh M, Kawaji H, Tsujikawa M, Nishida K.

    PLoS One   Vol. 10   page: e0117581   2015.3

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  41. The statistical geometry of transcriptome divergence in cell-type evolution and cancer Reviewed

    Liang C; FANTOM Consortium (Tatsukawa H), Forrest AR, Wagner GP.

    Nat Commun   Vol. 6   page: 6066   2015.1

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  42. CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes Reviewed

    Hasegawa Y, Tang D, Takahashi N, Hayashizaki Y, Forrest AR; FANTOM Consortium (Tatsukawa H), Suzuki H.

    Sci Rep   Vol. 4   page: 5228   2014.6

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  43. Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation Reviewed

    Morikawa H, Ohkura N, Vandenbon A, Itoh M, Nagao-Sato S, Kawaji H, Lassmann T, Carninci P, Hayashizaki Y, Forrest AR, Standley DM, Date H, Sakaguchi S; FANTOM Consortium (Tatsukawa H).

    Proc Natl Acad Sci U S A   Vol. 111 ( 14 ) page: 5289-5294   2014.4

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  44. An atlas of active enhancers across human cell types and tissues Reviewed

    Andersson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, Chen Y, Zhao X, Schmidl C, Suzuki T, Ntini E, Arner E, Valen E, Li K, Schwarzfischer L, Glatz D, Raithel J, Lilje B, Rapin N, Bagger FO, Jørgensen M, Andersen PR, Bertin N, Rackham O, Burroughs AM, Baillie JK, Ishizu Y, Shimizu Y, Furuhata E, Maeda S, Negishi Y, Mungall CJ, Meehan TF, Lassmann T, Itoh M, Kawaji H, Kondo N, Kawai J, Lennartsson A, Daub CO, Heutink P, Hume DA, Jensen TH, Suzuki H, Hayashizaki Y, Müller F; FANTOM Consortium (Tatsukawa H), Forrest AR, Carninci P, Rehli M, Sandelin A.

    Nature   Vol. 507 ( 7493 ) page: 455-461   2014.3

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  45. Ceruloplasmin is a novel adipokine which is overexpressed in adipose tissue of obese subjects and in obesity-associated cancer cells Reviewed

    Arner E, Forrest AR, Ehrlund A, Mejhert N, Itoh M, Kawaji H, Lassmann T, Laurencikiene J, Rydén M, Arner P; FANTOM Consortium (Tatsukawa H).

    PLoS One   Vol. 9 ( 3 ) page: e80274   2014.3

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  46. A promoter-level mammalian expression atlas Reviewed

    FANTOM Consortium and the RIKEN PMI and CLST (DGT), Forrest AR, Kawaji H, Rehli M, Baillie JK, de Hoon MJ, Haberle V, Lassman T, Kulakovskiy IV, Lizio M, Itoh M, Andersson R, Mungall CJ, Meehan TF, Schmeier S, Bertin N, Jørgensen M, Dimont E, Arner E, Schmidl C, Schaefer U, Medvedeva YA, Plessy C, Vitezic M, Severin J, Semple C, Ishizu Y, Young RS, Francescatto M, Alam I, Albanese D, Altschuler GM, Arakawa T, Archer JA, Arner P, Babina M, Rennie S, Balwierz PJ, Beckhouse AG, Pradhan-Bhatt S, Blake JA, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, Burroughs AM, Califano A, Cannistraci CV, Carbajo D, Chen Y, Chierici M, Ciani Y, Clevers HC, Dalla E, Davis CA, Detmar M, Diehl AD, Dohi T, Drabløs F, Edge AS, Edinger M, Ekwall K, Endoh M, Enomoto H, Fagiolini M, Fairbairn L, Fang H, Farach-Carson MC, Faulkner GJ, Favorov AV, Fisher ME, Frith MC, Fujita R, Fukuda S, Furlanello C, Furino M, Furusawa J, Geijtenbeek TB, Gibson AP, Gingeras T, Goldowitz D, Gough J, Guhl S, Guler R, Gustincich S, Ha TJ, Hamaguchi M, Hara M, Harbers M, Harshbarger J, Hasegawa A, Hasegawa Y, Hashimoto T, Herlyn M, Hitchens KJ, Ho Sui SJ, Hofmann OM, Hoof I, Hori F, Huminiecki L, Iida K, Ikawa T, Jankovic BR, Jia H, Joshi A, Jurman G, Kaczkowski B, Kai C, Kaida K, Kaiho A, Kajiyama K, Kanamori-Katayama M, Kasianov AS, Kasukawa T, Katayama S, Kato S, Kawaguchi S, Kawamoto H, Kawamura YI, Kawashima T, Kempfle JS, Kenna TJ, Kere J, Khachigian LM, Kitamura T, Klinken SP, Knox AJ, Kojima M, Kojima S, Kondo N, Koseki H, Koyasu S, Krampitz S, Kubosaki A, Kwon AT, Laros JF, Lee W, Lennartsson A, Li K, Lilje B, Lipovich L, Mackay-Sim A, Manabe R, Mar JC, Marchand B, Mathelier A, Mejhert N, Meynert A, Mizuno Y, de Lima Morais DA, Morikawa H, Morimoto M, Moro K, Motakis E, Motohashi H, Mummery CL, Murata M, Nagao-Sato S, Nakachi Y, Nakahara F, Nakamura T, Nakamura Y, Nakazato K, van Nimwegen E, Ninomiya N, Nishiyori H, Noma S, Noma S, Noazaki T, Ogishima S, Ohkura N, Ohimiya H, Ohno H, Ohshima M, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov DA, Pain A, Passier R, Patrikakis M, Persson H, Piazza S, Prendergast JG, Rackham OJ, Ramilowski JA, Rashid M, Ravasi T, Rizzu P, Roncador M, Roy S, Rye MB, Saijyo E, Sajantila A, Saka A, Sakaguchi S, Sakai M, Sato H, Savvi S, Saxena A, Schneider C, Schultes EA, Schulze-Tanzil GG, Schwegmann A, Sengstag T, Sheng G, Shimoji H, Shimoni Y, Shin JW, Simon C, Sugiyama D, Sugiyama T, Suzuki M, Suzuki N, Swoboda RK, 't Hoen PA, Tagami M, Takahashi N, Takai J, Tanaka H, Tatsukawa H, Tatum Z, Thompson M, Toyodo H, Toyoda T, Valen E, van de Wetering M, van den Berg LM, Verado R, Vijayan D, Vorontsov IE, Wasserman WW, Watanabe S, Wells CA, Winteringham LN, Wolvetang E, Wood EJ, Yamaguchi Y, Yamamoto M, Yoneda M, Yonekura Y, Yoshida S, Zabierowski SE, Zhang PG, Zhao X, Zucchelli S, Summers KM, Suzuki H, Daub CO, Kawai J, Heutink P, Hide W, Freeman TC, Lenhard B, Bajic VB, Taylor MS, Makeev VJ, Sandelin A, Hume DA, Carninci P, Hayashizaki Y

    Nature   Vol. 507 ( 7493 ) page: 462-470   2014.3

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  47. Variations in Both TG1 and TG2 Isozyme-specific in situ Activities and Protein Expressions during Mouse Embryonic Development Reviewed

    Itoh M, Tatsukawa H, Eun-Seo L, Yamanishi K, Kojima S and Hitomi K

    J Histochem Cytochem   Vol. 61 ( 11 ) page: 793-801   2013.11

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  48. Pituitary adenylate cyclase-activating polypeptide type 1 receptor (PAC1) gene is suppressed by transglutaminase 2 activation Reviewed

    Miura A, Kambe Y, Inoue K, Tatsukawa H, Kurihara T, Griffin M, Kojima S and Miyata A

    J Biol Chem   Vol. 288 ( 45 ) page: 32720-32730   2013.11

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  49. Phage-displayed peptide library screening for preferred human substrate peptide sequences for transglutaminase 7 Reviewed

    Kuramoto K, Yamasaki R, Shimizu Y, Tatsukawa H and Hitomi K

    Arch Biochem Biophys   Vol. 537 ( 1 ) page: 138-143   2013.9

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  50. 異常な細胞増殖・代謝にかかわるタンパク質の糖鎖修飾 Invited Reviewed

    辰川英樹

    ファルマシア   Vol. 49 ( 7 ) page: 701   2013.7

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  51. Regulation of transglutaminase-mediated hepatic cell death in alcoholic steatohepatitis and non-alcoholic steatohepatitis

    Kojima S, Kuo TF and Tatsukawa H

    J Gastroenterol Hepatol   Vol. 27   page: 52-57   2012.3

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    DOI: doi:10.1111/j.1440-1746.2011.07009.x

  52. Free fatty acids induce transglutaminase 2-dependent apoptosis in hepatocytes via ER stress-stimulated PERK pathways

    Kuo TF, Tatsukawa H, Matsuura T, Nagatsuma K, Hirose S and Kojima S

    J Cell Physiol   Vol. 227 ( 3 ) page: 1130-1137   2012.3

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    DOI: 10.1002/jcp.22833

  53. New insights into the functions and localization of nuclear transglutaminase 2

    Kuo TF, Tatsukawa H and Kojima S

    FEBS J   Vol. 278   page: 4756-4767   2011.12

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  54. Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells Reviewed

    Tatsukawa H, Sano T, Fukaya Y, Ishibashi N, Watanabe M, Okuno M, Moriwaki H and Kojima S

    Mol Cancer   Vol. 10   page: 4 (11 pages)   2011.1

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  55. Brain infarction correlates more closely with acrolein than with reactive oxygen species

    Saiki R, Park H, Ishii I, Yoshida M, Nishimura K, Toida T, Tatsukawa H, Kojima S, Ikeguchi Y, Pegg AE, Kashiwagi K and Igarashi K

    Biochem Biophys Res Commun   Vol. 404 ( 4 ) page: 1044-1049   2011.1

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  56. In situ detection of active transglutaminases for keratinocyte type (TGase 1) and tissue type (TGase 2) using fluorescence-labeled highly reactive substrate peptides

    Itoh M, Kawamoto T, Tatsukawa H, Kojima S, Yamanishi K and Hitomi K

    J Histochem Cytochem   Vol. 59   page: 180-187   2010.9

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    DOI: 10.1369/jhc.2010.957225

  57. Recent Advances in the Understanding of Roles of Transglutaminase 2 in Alcoholic Steatohepatitis

    Tatsukawa H and Kojima S

    Cell Biology International   Vol. 34   page: 325-334   2010.3

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  58. Induction of Cross-Linking and Silencing of Sp1 by Transglutaminase during Liver Injury in ASH and NASH via Different ER Stress Pathways

    Kojima S, Kuo TF, Tatsukawa H and Hirose S

    Digestive Diseases   Vol. 28   page: 715-721   2010

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  59. 生きた細胞でのヒストンアセチル化をリアルタイムで観察

    辰川英樹

      Vol. 2 ( 3 ) page: 20   2009.12

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  60. アルコール性肝障害の新規肝細胞死誘導経路の発見

    辰川英樹, 小嶋聡一

    バイオサイエンスとインダストリー   Vol. 67 ( 8 ) page: 423-427   2009.11

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  61. Role of Transglutaminase 2 in Liver Injury via Crosslinking and Silencing of Transcription Factor, Sp1 Reviewed

    Tatsukawa H, Fukaya Y, Frampton G, Martinez-Fuentes A, Suzuki K, Kuo TF, Nagatsuma K, Shimokado K, Okuno M, Wu J, Iismaa S, Matsuura T, Tsukamoto H, Zern MA, Graham RM, and Kojima S

    Gastroenterology   Vol. 136 ( 5 ) page: 1502-1505   2009.5

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  62. アテローム性動脈硬化症発症過程における血漿トランスグルタミナーゼ(XIIIA因子)による単球のアンジオテンシンⅡ受容体(AT1受容体)架橋二量体の形成

    辰川英樹

    日本血栓止血学会   Vol. 16 ( 3 ) page: 339   2005.3

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  63. 生体内バイオハイブリッド反応-架橋多機能性酵素、トランスグルタミナーゼによるタンパク質の機能変換

    辰川英樹,小嶋聡一

    化学工業   Vol. 54   page: 908-915   2003.12

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▼display all

Books 2

  1. Transglutaminase: Multiple Functional Modifiers and Targets for New Drug Discovery - Preferred Substrate Structure of Transglutaminases

    Hitomi K and Tatsukawa H( Role: Joint author)

    Springer  2016.3 

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    Language:English

  2. 肝疾患Review 2010~2011

    辰川英樹, 小嶋聡一( Role: Joint author)

    日本メディカルセンター出版  2010.5 

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    Language:Japanese

MISC 4

  1. 羊水中に存在する表皮細胞分化制御成分の性状解析

    栗林美樹, 手島裕文, 川口友輔, 川口友輔, 山口央輝, 辰川英樹, 人見清隆

    日本分子生物学会年会プログラム・要旨集(Web)   Vol. 43rd   2020

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  2. 糸球体腎炎に関わるタンパク質架橋化酵素の機能解明に向けた基礎的研究

    伊藤辰将, 辰川英樹, 山口央輝, 高橋和男, 人見清隆, 湯澤由紀夫

    日本腎臓学会誌   Vol. 61 ( 3 ) page: 340   2019.5

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    Language:Japanese  

    J-GLOBAL

  3. マウスの胎生進行に伴う表皮形成レベルと羊水成分の変動解析

    栗林美樹, 手島裕文, 加藤まなみ, 山口央輝, 辰川英樹, 人見清隆

    日本分子生物学会年会プログラム・要旨集(Web)   Vol. 42nd   2019

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  4. マウス腎糸球体内で架橋される組織型トランスグルタミナーゼ基質候補タンパク質の網羅的解析

    伊藤辰将, 伊藤辰将, 辰川英樹, 山口央輝, 高橋和男, 人見清隆, 湯澤由紀夫

    JSBMS Letters   Vol. 43 ( Supplement ) page: 104 - 104   2018.8

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    Language:Japanese   Publisher:(一社)日本医用マススペクトル学会  

    J-GLOBAL

Presentations 66

  1. Analysis of the mechanism of transglutaminase-mediated tissue fibrosis Invited

    Hideki Tatsukawa, Yoshiki Shinoda, Taishu Takeuchi, Suguru Niwa, Kiyotaka Hitomi

    2020.9.15 

  2. Characterization of substrates crosslinked by transglutaminase in fibrotic diseases Invited

    Hideki Tatsukawa, Taishu Takeuchi, Yoshiki Shinoda, Kiyotaka Hitomi

    Gordon Research Conference on Transglutaminases in Human Disease Processes  2020.6.16 

  3. Isozyme-specific identification and characterization of substrates crosslinked by transglutaminases in liver fibrosis International conference

    Hideki Tatsukawa, Kiyotaka Hitomi

    The 13th International Symposium on ALPD and Cirrhosis 

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    Event date: 2018.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  4. Isozyme-Specific Global Identification and Analysis of Transglutaminase Substrates in Fibrotic Diseases Invited International conference

    Hideki Tatsukawa

    Gordon Research Conference on Transglutaminases in Human Disease Processes 

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    Event date: 2018.6

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  5. Global identification and analysis of isozyme-specific substrates crosslinked by transglutaminase in mouse fibrosis model Invited

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  6. Detections of Isozyme-specific activity and Substrate for Transglutaminase in Animal Models for Fibrotic Disease

    The 2nd Tokai Nephrology & Immunology Forum -Transglutaminases and Kidney Diseases-ase Processes - 

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    Event date: 2014.10

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  7. Detections of isozyme-specific activity and substrate for transglutaminase in animal models for fibrotic disease International conference

    Tatsukawa H, Tani Y, Hitomi K

    Gordon reserch conference - Transglutaminases in Human Disease Processes - 

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    Event date: 2014.6 - 2014.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Italy  

  8. Crosslinking and Silencing of A Transcription Factor Sp1 by Transglutaminase during Liver Injury in ASH and NASH

    Tatsukawa H

    The 1st International Symposium on Latent TGF-β Activation Reaction -Development of Novel Diagnosis, Prevention, and Therapy Targeting TGF-β Activation Reaction 

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    Event date: 2012.3

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  9. Trials to identify a target molecule of acyclic retinoid, suppressing recurrence of hepatocellular carcinoma International conference

    Tatsukawa H, Honda K, Kondoh Y, Dohmae N, Ishibashi N, Osada H and Kojima S

    RIKEN - Max Planck Joint Research Center for Systems Chemical Biology Kick Off Symposium 

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    Event date: 2012.3

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  10. 肝細胞癌再発抑制剤「非環式レチノイド」の作用標的分子同定の試み

    辰川 英樹,本田 香織,近藤 恭光,堂前 直,石橋 直人,長田 裕之,森脇 久隆,小嶋 聡一

    第34回日本分子生物学会年会 

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    Event date: 2011.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  11. リン酸化RXRα特異抗体の作製および非環式レチノイドの標的分子同定の試み

    辰川 英樹,清水 雅仁,本田 香織,近藤 恭光,堂前 直,石橋 直人,長田 裕之,森脇 久隆,小嶋 聡一

    第22回日本レチノイド研究会学術集会 

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  12. 非環式レチノイドによる肝癌細胞死誘導機構の解析

    辰川 英樹,石橋 直人,森脇 久隆,小嶋 聡一

    第70回日本癌学会学術総会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  13. Analysis of nuclear localization of transglutaminase and screening of its inhibitors International conference

    Tatsukawa H, Yoshioka Y and Kojima S

    The 6th International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis 

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    Event date: 2011.10

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  14. 非環式レチノイドによる肝細胞癌の細胞死で見られたトランスグルタミナーゼ核局在の新機構

    辰川 英樹,石橋 直人,森脇 久隆,小嶋 聡一

    日本消化器関連学会機構(JDDW2011) 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  15. 肝臓癌細胞死に伴うタンパク質架橋結合酵素トランスグルタミナーゼ核局在の分子機構

    辰川 英樹,石橋 直人,小瀬 真吾,今本 尚子,森脇 久隆,小嶋 聡一

    第84回日本生化学会大会 

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    Event date: 2011.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  16. 非環式レチノイドによるタンパク架橋結合酵素を介した肝癌細胞死の誘導機構

    辰川 英樹,石橋 直人,森脇 久隆,小嶋 聡一

    第18回肝細胞研究会 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  17. 非環式レチノイドによる肝癌細胞死誘導に伴うタンパク質架橋結合酵素トランスグルタミナーゼ核局在の分子機構解明

    辰川 英樹,石橋 直人,小瀬 真吾,今本 尚子,森脇 久隆,小嶋 聡一

    平成23年度日本生化学会関東支部例会 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  18. 非環式レチノイドによる肝癌細胞死誘導機構 International conference

    辰川 英樹,石橋 直人,森脇 久隆,小嶋 聡一

    第33回日本分子生物学会年会&第83回日本生化学会大会(BMB2010) 

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    Event date: 2010.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  19. 非環式レチノイドによる肝臓癌細胞死に寄与するトランスグルタミナーゼの核移行の解析

    辰川 英樹,石橋 直人,森脇 久隆,小嶋 聡一

    第21回 日本レチノイド研究会 

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    Event date: 2010.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  20. Novel apoptotic pathway via crosslinking enzyme, transglutaminase: Its discovery and regulation

    Tatsukawa H

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    Event date: 2010.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  21. 非環式レチノイドによる肝細胞癌治療におけるリン酸化阻害作用と標的分子同定の試み

    辰川英樹,石橋 直人,森脇 久隆,小嶋 聡一

    第14回日本がん分子標的治療学会学術集会 

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    Event date: 2010.7

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  22. Analysis of nuclear localization of transglutaminase and screening of its inhibitors regulating nuclear transglutaminase activity International conference

    Tatsukawa H, Kouyama M, Tsukamoto H, Kojima S

    Gordon Research Conference on Transglutaminase in Human Disease Processes 

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    Event date: 2010.7

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  23. アルコール vs 遊離脂肪酸による肝障害誘導機構の比較検討

    辰川 英樹,Kuo Ting-Fang,松浦 知和,塚本 秀和,小嶋 聡一

    第46回日本肝臓学会総会 

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    Event date: 2010.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  24. 転写因子の架橋反応を標的とした肝障害の誘導機構とその制御

    辰川英樹,高山弥緒,松浦知和,塚本秀和,小嶋聡一

    第5回日本ケミカルバイオロジー学会 

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    Event date: 2010.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  25. Mechanism of liver injury (hepatocyte cell death) via crosslinking of a transcription factor

    Tatsukawa H, Kojima S

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    Event date: 2010.2

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  26. タンパク質の架橋反応が細胞死を招き、アルコール性肝障害に- アルコール性障害の肝臓で繰り広げられる新しい肝細胞死のメカニズムを発見

    辰川 英樹,小嶋聡一

    第22回理化学研究所と産業界との交流会 

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    Event date: 2010.2

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  27. Detection and regulation of alcoholic liver injury via controlling protein crosslinking enzyme, transglutaminase

    Tatsukawa H, Kouyama M, Matsuura T, Tsukamoto H, Kojima S

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    Event date: 2010.2

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  28. 転写因子の架橋反応を介する肝障害(肝細胞死)の誘導機構

    辰川 英樹,松浦知和,塚本秀和,小嶋聡一

    第32回日本分子生物学会年会 

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    Event date: 2009.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  29. Screening of novel compounds to prevent alcoholic liver injury targeting transglutaminase International conference

    Tatsukawa H, Kouyama M, Tsukamoto H, Kojima S

    The 4th International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis 

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    Event date: 2009.10

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  30. 転写因子の架橋反応を標的とした肝障害(肝細胞死)の誘導機構とその制御

    第4回 トランスグルタミナーゼ研究会&日本ポリアミン学会合同学術集会

    辰川 英樹,小嶋 聡一 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  31. Novel Mechanism of Acyclic Retinoid-induced Apoptosis in Hepatocellular Carcinoma Cells - Dual Induction of Caspase 3- and Transglutaminase-dependent Apoptotic Pathways - International conference

    Tatsukawa H, Sano T, Ishibashi N, Okuno M, Moriwaki H and Kojima S

    The 60th Annual meeting of the American Association for the Study of Liver Diseases 

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    Event date: 2009.10

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  32. “転写因子の架橋反応を標的とした肝障害(肝細胞死)の誘導機構とその制御

    辰川 英樹,高山 弥緒,松浦 知和,塚本 秀和,小嶋 聡一

    第82回日本生化学大会 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  33. 転写因子の架橋反応を標的とした肝障害(肝細胞死)の誘導機構とその制御

    辰川 英樹,小嶋 聡一

    第3回トランスグルタミナーゼ研究会&ポリアミン研究会 合同学術集会 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  34. Screening of novel compounds to prevent alcoholic liver injury

    The 25th Naito Conference on Chemical Biology [II] 

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    Event date: 2009.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  35. 非環式レチノイドによる肝癌細胞のアポトーシス誘導機構

    辰川 英樹,深谷 弥生,石橋 直人,佐野 哲朗,下門 顕太郎,森脇 久隆,小嶋 聡一

    第45回日本肝臓学会総会 

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    Event date: 2009.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  36. Role of Transglutaminase 2 in Liver Injury via Crosslinking and Silencing of Transcription Factor, Sp1

    Tatsukawa H, Tsukamoto H, Shimokado K, Zern MA, Graham RM, Kojima S

    RIEKN 2009 JOINT RETREAT 

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    Event date: 2009.1

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  37. 非環式レチノイドによる肝癌細胞のアポトーシス誘導に関する研究

    辰川 英樹,深谷 弥生,石橋 直人,佐野 哲朗,下門 顕太郎,森脇 久隆,小嶋 聡一

    BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会) 

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    Event date: 2008.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  38. 非環式レチノイドによる肝癌細胞のアポトーシス誘導機構

    辰川 英樹,深谷 弥生,石橋 直人,佐野 哲朗,下門 顕太郎,森脇 久隆,小嶋 聡一

    第19回 日本レチノイド研究会 

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    Event date: 2008.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  39. A novel hepatic apoptosis pathway in the injured liver via crosslinking and inactivation of transcription factor, Sp1 by tissue transglutaminase International conference

    Tatsukawa H, Tsukamoto H, Shimokado K, Zern MA, Graham RM, Kojima S

    The 59th Annual meeting of the American Association for the Study of Liver Diseases 

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    Event date: 2008.10

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  40. タンパク質架橋結合酵素トランスグルタミナーゼによるアポトーシス誘導の制御

    辰川 英樹、深谷 弥生、小嶋 聡一

    第1回理研ケミカルバイオロジー研究領域国際シンポジウム 

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    Event date: 2008.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  41. 非環式レチノイドによる肝癌細胞死の誘導機構

    辰川 英樹,深谷 弥生,石橋 直人,佐野 哲朗,下門 顕太郎,森脇 久隆,小嶋 聡一

    第3回日本ケミカルバイオロジー研究会 

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    Event date: 2008.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  42. 肝癌細胞のアポトーシス誘導に伴うタンパク質架橋結合酵素の核移行

    辰川英樹,下門 顕太郎,辻本雅文,小嶋 聡一

    第4回ケミカルバイオロジーシンポジウム 

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    Event date: 2008.2

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  43. トランスグルタミナーゼを介したアポトーシス誘導機構

    辰川英樹,下門顕太郎,小嶋聡一

    第10回TGase研究会 

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    Event date: 2007.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  44. 非環式レチノイドによる肝癌細胞死の分子機構

    辰川 英樹,深谷 弥生,石橋 直人,佐野 哲朗,下門 顕太郎,森脇 久隆,小嶋 聡一

    BMB2007(第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会) 

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    Event date: 2007.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  45. 非環式レチノイドによる肝癌細胞死の誘導機構

    辰川英樹,深谷弥生,石橋直人,森脇 久隆,下門 顕太郎,小嶋聡一

    第18回 日本レチノイド研究会 

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    Event date: 2007.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  46. Mechanism of a novel apoptotic pathway in the injured liver via crosslinking and inactivation of transcription factor, Sp1 International conference

    Tatsukawa H, Shimokado K, Kojima S

    The 2nd International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis 

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    Event date: 2007.10

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  47. MOLECULAR MECHANISM FOR SUPPRESSION OF HEPATOCELLULAR CARCINOMA BY ACYCLIC RETINOID International conference

    Tatsukawa H, Sano T, Ishibashi N, Shimokado K, Tsujimoto M, Kojima S

    9th International conference on transglutaminases and protein cross linking 

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    Event date: 2007.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  48. タンパク質架橋酵素トランスグルタミナーゼを介する細胞死の制御

    辰川英樹,深谷弥生,小嶋聡一

    バイオアーキテクトシンポジウム2007 

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    Event date: 2007.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  49. タンパク架橋結合酵素トランスグルタミナーゼを介した肝癌細胞死の誘導機構

    辰川英樹,深谷 弥生,佐野 哲朗,森脇 久隆,下門 顕太郎,小嶋 聡一

    日本レチノイド研究会 

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    Event date: 2006.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  50. 転写因子の架橋不活性化反応における転写因子の特異性に関する研究

    辰川英樹,深谷弥生,鈴木健司,下門顕太郎,小嶋聡一

    第5回「ポリアミンと核酸の共進化」合同シンポジウム 

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    Event date: 2006.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  51. タンパク質架橋酵素トランスグルタミナーゼを介した細胞死の制御

    辰川英樹,下門顕太郎,小嶋聡一

    第9回TGase研究会 

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    Event date: 2006.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  52. Analysis of mechanism of a novel apoptotic pathway via crosslinking and inactivation of the transcription factor, Sp1 International conference

    Tatsukawa H,Shimokado K,Kojima S

    20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress 

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    Event date: 2006.6

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  53. 非環式レチノイドによる核内トランスグルタミナーゼ誘導を介する肝癌細胞死

    辰川英樹,深谷 弥生,奥野 正隆,佐野 哲朗,森脇 久隆,下門 顕太郎,小嶋 聡一

    第1回 日本ケミカルバイオロジー研究会 

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    Event date: 2006.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  54. タンパク架橋結合酵素トランスグルタミナーゼを介する新規アポトーシス(グルネーシス)の検出

    辰川英樹,中野なおこ,下門顕太郎,小嶋聡一

    第78回日本生化学会大会 

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    Event date: 2005.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  55. 組織トランスグルタミナーゼを介したアポトーシス

    辰川英樹,小嶋聡一

    第1回 TGase研究会&ポリアミン研究会 合同学術集会 

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    Event date: 2005.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  56. Novel apoptosis induced by a protein crosslinking enzyme, transglutaminase (Glunasis)

    Tatsukawa H

    RIKEN JOINT RETREAT 

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    Event date: 2005.5

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  57. 架橋Sp1抗体を用いた新規アポトーシスの検出

    辰川英樹,深谷弥生,下門顕太郎,小嶋聡一

    第27回日本分子生物学会年会 

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    Event date: 2004.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  58. レチノイドによる血管新生の制御におけるトランスグルタミナーゼの役割 International conference

    辰川英樹,深谷弥生,下門顕太郎,小嶋聡一

    第77回日本生化学会大会 

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    Event date: 2004.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  59. レチノイドによる血管新生の調節におけるトランスグルタミナーゼの役割

    辰川英樹,下門顕太郎,小嶋聡一

    第8回TGase研究会 

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    Event date: 2004.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  60. A Role of Transglutaminase in the Regulation of Angiogenesis by Retinoid International conference

    Tatsukawa H, Fukaya Y, Shimokado K, and Kojima S

    10th Int. International Society of Hematology, Asian-Pacific Division 

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    Event date: 2004.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  61. トランスグルタミナーゼを介するアポトーシスの誘導

    辰川英樹,深谷弥生,奥野正隆,佐野哲朗,森脇久隆,下門顕太郎,小嶋聡一

    第3回「ポリアミンと核酸の共進化」合同シンポジウム 

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    Event date: 2004.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  62. トランスグルタミナーゼを介する肝細胞死の分子機構

    辰川英樹,Mark A. Zern,下門顕太郎,小嶋聡一

    第19回バイオハイブリッド研究 

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    Event date: 2004.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  63. アンチセンス高発現細胞株を用いたトランスグルタミナーゼ誘導を介する肝癌細胞死の証明

    辰川英樹,深谷弥生,奥野正隆,佐野哲朗,森脇久隆,下門顕太郎,小嶋聡一

    第26回日本分子生物学会年会 

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    Event date: 2003.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  64. トランスグルタミナーゼ誘導を介する肝癌細胞死の証明

    辰川英樹,深谷弥生,奥野正隆,佐野哲朗,森脇久隆,下門顕太郎,小嶋聡一

    辰川英樹,深谷弥生,奥野正隆,佐野哲朗,森脇久隆,下門顕太郎,小嶋聡一 

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    Event date: 2003.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  65. A Role of Tissue Transglutaminase in Hepatocyte Apoptosis

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    Event date: 2003.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  66. トランスグルタミナーゼ誘導を介する肝癌細胞死の分子機構解析

    辰川英樹,奥野正隆,佐野哲郎,森脇久隆,下仲基之,小嶋聡一

    第25回日本分子生物学会年会 

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    Event date: 2002.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

▼display all

Research Project for Joint Research, Competitive Funding, etc. 2

  1. 線維化組織に介在する架橋タンパク質群の網羅的同定・解析

    2016.5 - 2017.5

  2. 研究奨励ファンド

    2009.4 - 2010.3

KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. 尿細管上皮の間葉転換を制御するタンパク質架橋修飾の役割

    2019.4 - 2022.3

    科学研究費補助金  基盤研究(C)

    辰川 英樹

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    Authorship:Principal investigator 

  2. 尿細管上皮の間葉転換を制御するタンパク質架橋修飾の役割

    Grant number:19K08675  2019.4 - 2022.3

    辰川 英樹

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    Authorship:Principal investigator 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    慢性腎臓病は日本国内で1,330万人(成人の8人に1人)が罹患する国民病である。慢性腎臓病が末期腎不全に至る共通の過程として線維化があり、線維化の程度は腎機能低下と相関する。腎線維化の直接の発症要因は筋線維芽細胞による細胞外基質の過剰産生であるが、近年この筋線維芽細胞の活性化に関わる炎症反応の起点として尿細管上皮細胞の上皮間葉転換(EMT)が重要視されている。申請者は最近、表皮型のタンパク質架橋酵素が腎尿細管上皮において活性化し、EMTに対して保護(抑制)的な作用を示すことを見出しており、これらの分子機構の解明を目的として研究を遂行する。
    腎線維化は組織に細胞外マトリクスが過剰に蓄積し、正常な機能が失われる疾患である。腎線維化の病態初期では、腎尿細管上皮細胞の上皮間葉転換(EMT)や細胞死が病態形成の起点として考えられている。これまでの研究により、病態初期においてこのような尿細管上皮細胞の形質転換が、皮膚型のタンパク質架橋酵素トランスグルタミナーゼ(TG1)により制御されることを見出しており、この分子機構の解明を目指し、本年度は以下の3つの点について実験を実施した。<BR>
    ① 尿細管上皮細胞株HK-2を播種し、TG1に特異的なsiRNAを用いて遺伝子発現を抑制した後にTGF-βやH2O2処理によるEMTや細胞死を誘導したところ、TG1は上皮細胞に対して保護的に働き、同一ファミリーの別のアイソザイムであるTG2はTGF-βの作用因子として働くことが示された。
    ② TGF-βやH2O2処理したHK-2に架橋酵素のリジン残基側の基質であるビオチン標識一級アミンBPAを添加して、EMTや細胞死誘導時においてTGase活性により取り込まれるBPA修飾タンパク質の経時的な変化を検出した。EMTや細胞死誘導処理の12時間後にBPA修飾タンパク質が増大したことから、EMTや細胞死の誘導に伴いTGaseの活性が上昇し、特定のタンパク質を基質として架橋することにより、EMTや細胞死誘導機構を制御することが示唆された。今後はこれらのBPA修飾タンパク質を精製し、網羅的な同定解析を目指す。
    ③ TG1の全身欠損マウスは表皮の形成異常により致死性であるため、Creレコンビナーゼにより時期や細胞種特異的にTG1を欠損することが可能なTG1flox/flox 変異マウスをCRISPRにより作製した。現在、同マウスとタモキシフェンにより制御可能なCreERT2もしくは尿細管特異的に発現するgGT-Creの変異マウスと掛け合わせを進めている。
    尿細管上皮細胞での表皮型タンパク質架橋酵素の実態解明のために提案した以下の点についての進捗状況を示す。<BR>
    架橋酵素の発現・活性化が尿細管上皮細胞のEMTおよび細胞死において、in vitro実験でのおおよそどのタイミングで発現・活性が上昇するのかについて情報を得た。また、架橋酵素の活性化に伴い修飾されるビオチン化ペンチルアミン(BPA)を指標として、特定の時期に特異的なバンドが増加することを見出した。架橋酵素が発現・活性化する制御機構については、詳細な解析がまだ出来ていないものの、上記の内容を加味して、概ね順調に進展していると考える。<BR>
    TG1を時期・細胞特異的に欠損するためのTG1flox/floxマウスについては、CRISPRを用いて既に作製済みであるため、当初の計画以上に実験が進展している。
    TGF-βもしくはH2O2処理した尿細管上皮細胞において、EMTおよび細胞死を誘導する際の架橋酵素の発現・活性化の経時的変化については検証済みであり、今後は同条件において、EMTや細胞死のシグナル伝達機構の特定、プロテオーム解析による架橋される基質タンパク質の網羅的同定を行っていく。<BR>
    Creレコンビナーゼ誘導性のTG1欠損マウスについても既に作製済みであり、早期に対象のCreマウスとの掛け合わせが終了する見込みであるため、完成した変異マウスを用いて腎線維化の病態モデルを誘導し、順次表現型解析を進めていく。

  3. 組織線維化に寄与する架橋修飾因子の網羅的解析および線維化抑制剤の開発

    2016.4 - 2019.3

    科学研究費補助金  基盤研究(C)

    辰川英樹

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    Authorship:Principal investigator 

  4. Global identification of the substrates of protein crosslinking enzyme and the development of preventive drug in tissue fibrosis

    Grant number:16K09353  2016.4 - 2019.3

    TATSUKAWA Hideki

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    The transglutaminase (TG) family comprises eight isozymes that catalyze the crosslinking reaction between glutamine and lysine residues and contribute to the fibrotic diseases in several tissues. Despite the evidence implicating TG2 as a key enzyme in fibrosis, the causative role and involvement of the other isozymes have not yet been fully elucidated. Therefore, here we clarified the distributions and activities of TG isozymes, and identified the isozyme-specific substrates for both TG1 and TG2 using each substrate peptide. The possible substrates for each TG were successfully identified and these included keratin 18, a biomarker for hepatic injury, which was accumulated in the fibrotic liver. Our findings suggest that each TG was independently activated in a different tissue area during fibrotic induction, and played a potential role in the functional modification of keratin 18, which are relevant to liver fibrosis progression.

  5. タンパク質架橋化酵素を標的とした肝線維化の病態機序の解明および制御法の開発

    2014.4

    科学研究費補助金  若手研究(B)

    辰川英樹

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    Authorship:Principal investigator 

  6. 非環式レチノイドによる肝臓癌特異的細胞死の経路解析に基づく新規抗癌剤の開発

    2010.4 - 2013.3

    科学研究費補助金  若手研究(B)

    辰川英樹

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    Authorship:Principal investigator 

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Teaching Experience (On-campus) 8

  1. 応用生命科学科実験実習

    2020

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    農学部応用生命科学科実験実習の中の細胞生物学実習(10日間)を担当する。
    G30学生対応のための英語による実習講義を含む

  2. 応用生命科学科実験実習

    2016

  3. 創薬生物科学実験

    2016

  4. 多分野融合実践演習

    2016

  5. 創薬生物科学セミナーⅠB

    2016

  6. 創薬生物科学セミナーⅠA

    2016

  7. 多分野融合実践実習

    2016

  8. 情報リテラシー入門

    2014

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Media Coverage 3

  1. 特発性肺線維症、病態発症メカニズムの⼀端を明らかに-名⼤ Internet

    医療ニュース QLifePro  2021.7

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    Author:Other 

  2. 肺線維症の分子標的の探索法開発および同定に成功 ~架橋修飾反応が関わる特発性肺線維症の発症機構の解明~

    名古屋大学プレスリリース  2021.7

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    Author:Myself 

  3. 特発性肺線維症(IPF)発症メカニズ ムの⼀端を解明 Internet

    難病・希少疾患 情報サイト RareS. (レアズ)  2021.7

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    Author:Other