Updated on 2022/11/21

写真a

 
ABE Hideki
 
Organization
Graduate School of Bioagricultural Sciences Department of Animal Sciences Associate professor
Graduate School
Graduate School of Bioagricultural Sciences
Undergraduate School
School of Agricultural Sciences
Title
Associate professor
Contact information
メールアドレス
Profile
I have been working on neuromodulatory mechanism of peptidergic neuronal systems in the CNS using extrahypothalamic gonadotropin-releasing hormone (GnRH) neuronal system of the teleosts (dwarf gourami, goldfish, and medaka) as models for better understanding of animal behavior.
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Degree 1

  1. 博士(理学) ( 2000.3   東京大学 ) 

Research Interests 12

  1. tetrodotoxin

  2. olfaction

  3. 開口放出

  4. 興奮-分泌連関

  5. 神経修飾

  6. 生理学

  7. ペプチド放出

  8. ペプチドニューロン

  9. パッチクランプ

  10. カルシウム

  11. イメージング

  12. GnRH

Research Areas 3

  1. Life Science / Neuroscience-general  / 神経科学一般関連

  2. Life Science / Aquatic life science

  3. Life Science / Animal physiological chemistry, physiology and behavioral biology  / 動物生理化学、生理学および行動学関連

Current Research Project and SDGs 3

  1. Sensory physiology of fish (vision, olfaction, taste, etc.)

  2. Neuromodulatory action of extrahypothalamic GnRH neurons on sensory information processing in CNS

  3. Excitation-secretion coupling of single peptidergic neurons

Research History 7

  1. Grad. School of Bioagricultural Sciences, Nagoya University   Dept. of Animal Sciences, Laboratory of Fishbiology   Associate professor

    2018.4

  2. Lab. of Fish Biology, Grad School of Bioagricultural Sciences, Nagoya University   Associate professor

    2012.4 - 2018.3

  3. Assistant professor, Grad. School of Science, The Univ. of Tokyo   Assistant Professor

    2007.4 - 2012.3

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    Country:Japan

  4. 東京大学 理学系研究科   助教

    2007.4 - 2012.3

  5. Assistant professor, Grad. School of Science, The Univ. of Tokyo   Assistant

    2004.10 - 2007.3

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    Country:Japan

  6. National Primate Research Center, Univ. of Wisconsin-Madison   Research Associate

    2002.10 - 2004.9

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    Country:United States

  7. Postdoctral fellow, CREST, JST & Dept. of Physiology, Tokyo Medical and Dental Univ.

    2000.4 - 2002.9

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    Country:Japan

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Education 3

  1. The University of Tokyo   Graduate School, Division of Science

    1996.4 - 2000.3

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    Country: Japan

  2. Yokohama City University   Graduate School, Division of Integrated Science

    1994.4 - 1996.3

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    Country: Japan

  3. Shizuoka University   Faculty of Science

    1990.4 - 1994.3

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    Country: Japan

Professional Memberships 6

  1. Zoological Society of Japan

    1997

  2. Japan Neuroscience Society

  3. Society for Neuroscience

  4. 日本水産学会

  5. Physiological Society of Japan

  6. ニューロエソロジー談話会

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Committee Memberships 13

  1. 日本動物学会   理事(広報・IT 担当)  

    2020.9 - 2022.8   

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    Committee type:Academic society

  2. 日本動物学会   第91回大会(オンライン)実行委員  

    2020.6 - 2020.9   

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    Committee type:Academic society

  3. 独立行政法人大学入試センター   問題作成部会委員  

    2019.4 - 2021.3   

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    Committee type:Other

  4. 日本動物学会   中部支部地区委員(愛知県)  

    2018.9 - 2020.8   

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    Committee type:Academic society

  5. 日本動物学会   将来計画委員会 委員  

    2017.10   

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    Committee type:Academic society

  6. 日本動物学会   第88回大会実行委員会委員  

    2016.2 - 2018.9   

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    Committee type:Academic society

  7. 日本動物学会   IT委員会 委員長  

    2014.9 - 2017.9   

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    Committee type:Academic society

  8. 独立行政法人大学入試センター   教科科目第一委員会 委員  

    2013.4 - 2015.3   

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    Committee type:Government

  9. 日本動物学会   IT化推進ワーキンググループ委員  

    2012.10 - 2014.9   

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    Committee type:Academic society

  10. 日本動物学会   関東地区支部委員  

    2007.1 - 2010.12   

  11. (社)日本動物学会   関東地区支部委員  

    2007.1 - 2010.12   

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    Committee type:Academic society

  12. (社)日本動物学会   生物科学ニュース編集委員  

    2007.1 - 2009.12   

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    Committee type:Academic society

  13. 日本動物学会   生物科学ニュース編集委員会委員  

    2007.1 - 2009.1   

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Awards 1

  1. Zoological Science Award (Endocrinology)

    2003.9  

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    Country:Japan

 

Papers 43

  1. Green spotted puffer can detect an almost nontoxic TTX analog odor using crypt olfactory sensory neurons. Reviewed

    Suzuki, T., Nakahigashi, R., Adachi, M., Nishikawa, T., & Abe, H.

    Chemical Senses   Vol. 47   2022.5

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/chemse/bjac011

  2. Almost nontoxic tetrodotoxin analog, 5,6,11-trideoxytetrodotoxin, as an olfactory chemoattractant for the grass puffer.

    Noguchi, Y., Suzuki, T., Matsutani, K., Sakakibara, R., Nakahigashi, R., Adachi, M., Nishikawa, T., & Abe, H.

    bioRxiv     2021.10

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (other academic)  

    DOI: 10.1101/2021.09.12.459881

  3. Gene disruption of medaka (Oryzias latipes) orthologue for mammalian tissue-type transglutaminase (TG2) causes movement retardation. Reviewed International journal

    Yuko Watanabe, Kazuho Okuya, Yuki Takada, Masato Kinoshita, Saori Yokoi, Shinichi Chisada, Yasuhiro Kamei, Hideki Tatsukawa, Naoyuki Yamamoto, Hideki Abe, Hisashi Hashimoto, Kiyotaka Hitomi

    Journal of biochemistry   Vol. 168 ( 3 ) page: 213 - 222   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    Transglutaminases (TGases) are an enzyme family that catalyzes protein cross-linking essential for several biological functions. In the previous studies, we characterized the orthologues of the mammalian TGase family in medaka (Oryzias latipes), an established fish model. Among the human isozymes, tissue-type transglutaminase (TG2) has multiple functions that are involved in several biological phenomena. In this study, we established medaka mutants deficient for the orthologue of human TG2 (OlTGT) using the CRISPR/Cas9 and TALEN systems. Although apparent morphological changes in the phenotype were not observed, movement retardation was found in the mutant fish when evaluated by a tank diving test. Furthermore, comparative immunohistochemistry analysis using in this fish model revealed that OlTGT was expressed at the periventricular layer of the optic tectum. Our findings provide novel insight for the relationship between tissue-type TGase and the nervous system and the associated behavior.

    DOI: 10.1093/jb/mvaa038

    Web of Science

    PubMed

  4. Afferent and efferent connections of the nucleus prethalamicus in the yellowfin goby Acanthogobius flavimanus. Reviewed International journal

    Hanako Hagio, Masahumi Kawaguchi, Hideki Abe, Naoyuki Yamamoto

    The Journal of comparative neurology   Vol. 529 ( 1 ) page: 87 - 110   2020.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    The nucleus prethalamicus (PTh) receives fibers from the optic tectum and then projects to the dorsal telencephalon in the yellowfin goby Acanthogobius flavimanus. However, it remained unclear whether the PTh is a visual relay nucleus, because the optic tectum receives not only visual but also other sensory modalities. Furthermore, precise telencephalic regions receiving prethalamic input remained unknown in the goby. We therefore investigated the full set of afferent and efferent connections of the PTh by direct tracer injections into the nucleus. Injections into the PTh labeled cells in the optic tectum, ventromedial thalamic nucleus, central and medial parts of the dorsal telencephalon, and caudal lobe of the cerebellum. We found that the somata of most tecto-prethalamic neurons are present in the stratum periventriculare. Their dendrites ascend to reach the major retinorecipient layers of the tectum. The PTh is composed of two subnuclei (medial and lateral) and topographic organization was appreciated only for tectal projections to the lateral subnucleus (PTh-l), which also receives sparse retinal projections. In contrast, the medial subnucleus receives fibers only from the medial tectum. We found that the PTh projects to nine subregions in the dorsal telencephalon and four in the ventral telencephalon. Furthermore, cerebellar injections revealed that cerebello-prethalamic fibers cross the midline twice to innervate the PTh-l on both sides. The present study is the first detailed report on the full set of the connections of PTh, which suggests that the PTh relays visual information from the optic tectum to the telencephalon. This article is protected by copyright. All rights reserved.

    DOI: 10.1002/cne.24935

    Web of Science

    PubMed

  5. Indirect pathway to pectoral fin motor neurons from nucleus ruber in the Nile tilapia Oreochromis niloticus Reviewed

    Nakayama Tomoya, Nishino Hirotaka, Narita Junya, Abe Hideki, Yamamoto Naoyuki

    JOURNAL OF COMPARATIVE NEUROLOGY   Vol. 527 ( 5 ) page: 957-971   2019.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cne.24578

    Web of Science

    PubMed

  6. Nucleus Ruber of Actinopterygians. Reviewed

    Nakayama T, Miyajima S, Nishino H, Narita J, Abe H, Yamamoto N

    Brain, behavior and evolution   Vol. 88 ( 1 ) page: 25-42   2016

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000447442

    PubMed

  7. GnRH suppresses excitability of visual processing neurons in the optic tectum. Reviewed

    Umatani C, Misu R, Oishi S, Yamaguchi K, Abe H, Oka Y

    Journal of neurophysiology   Vol. 114 ( 5 ) page: 2775-2784   2015.11

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/jn.00710.2015

    PubMed

  8. Morphological analysis of the early development of telencephalic and diencephalic gonadotropin-releasing hormone neuronal systems in the enhanced green fluorescent protein-expressing transgenic medaka lines Reviewed

    Takahashi, A., Islam, S.M., Abe, H., Okubo, K., Akazome, Y., Kaneko, T., Hioki, H., Oka, Y.

    J. Comp. Neurol.     page: 0000   2015.8

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  9. Connections of the commissural nucleus of Cajal in the goldfish with special reference to the topographic organization of ascending visceral sensory pathways, Reviewed

    Uezono S., Yamada Y., Kato T., Abe H., Yamamoto N.

    J. Comp. Neurol.   Vol. 523 ( 2 ) page: 209-225   2015.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cne.23675

  10. Kiss1 Neurons Drastically Change Their Firing Activity in Accordance With the Reproductive State: Insights From a Seasonal Breeder Reviewed

    Hasebe M., Kanda S., Shimada H., Akazome Y., Abe H., Oka Y.

    Endocrinology   Vol. 155 ( 12 ) page: 4868-4880   2014.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/en.2014-1472

  11. Intrinsic photosensitivity of deep brain photoreceptor Reviewed

    Nakane Y., Shimmura T., Abe H., Yoshimura T.

    Current Biology   Vol. 24   page: R596-597   2014.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cub.2014.05.038

  12. Whole brain-pituitary in vitro preparation of the transgenic medaka (Oryzias latipes) as a tool for analyzing the differential regulatory mechanisms of LH and FSH release Reviewed

    Karigo, T., Aikawa, M., Kondo, C., Abe, H., Kanda, S., Oka, Y.

    Endocrinology   Vol. 155   page: 536-547   2014.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/en.2013-1642

  13. A Neural Mechanism Underlying Mating Preferences for Familiar Individuals in Medaka Fish Reviewed

    Okuyama, T., Yokoi, S., Abe, H., Isoe, Y., Suehiro, Y., Imada, H., Tanaka, M., Kawasaki, T., Yuba, S., Taniguchi, Y., Kamei, Y., Okubo, K., Shimada, A., Natuse, K., Takeda, H., Oka, Y., Kubo, T., and Takeuchi, H.

    Science   Vol. 343 ( 6 ) page: 91-94   2014.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/science.1244724

  14. Burst generation mediated by cholinergic input in terminal nerve-gonadotrophin releasing hormone neurones of the goldfish Reviewed

    Kawai T., Abe H., Oka Y.

    J. Physiol.   Vol. 591   page: 5509-5523   2013.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1113/jphysiol.2013.258343

  15. The saccus vasculosus of fish is a sensor of seasonal changes in day length Reviewed

    Nakane, Y., Ikegami, K., Iigo, M., Ono, H., Takeda, K., Takahashi, D., Uesaka, M., Kimijima, M., Hashimoto, R., Arai, N., Suga, T., Kosuge, K., Abe, T., Maeda, R., Senga, T., Amiya, N., Azuma, T., Amano, M., Abe, H., Yamamoto, N. & Yoshimura, T.

    Nature Communications   Vol. 4   page: 2108   2013.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ncomms3108

  16. Neuropeptide RFRP inhibits the pacemaker activity of terminal nerve GnRH neurons Reviewed

    Umatani, C., Abe, H., Oka, Y.

    J. Neurophysiol.   Vol. 109   page: 2354-2363   2013.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/jn.00712.2012

  17. Morphological analysis of the early development of GnRH neuron systems in the EGFP-expressing transgenic medaka lines Reviewed International journal

    Takahashi A, Islam S, Akazome Y, Abe H, Okubo K, Oka Y

    Society for Neuroscience Abstract Viewer and Itinerary Planner   Vol. 43   2013

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    Publishing type:Research paper (international conference proceedings)  

    Other Link: http://orcid.org/0000-0002-3482-3051

  18. Time-of-Day-dependent changes in GnRH1 neuronal activities and gonadotropin mRNA expression in a daily spawning fish, medaka. Reviewed

    Karigo, T., Kanda, S., Takahashi, A., Abe, H., Okubo, K., Oka, Y.

    Endocrinology   Vol. 153 ( 7 ) page: 3394-3404   2012.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/en.2011-2022

  19. Dopaminergic neuromodulation of synaptic transmission between the mitral and granule cells in the teleost olfactory bulb. Reviewed

    Kawai, T., Abe, H., and Oka, Y.

    J. Neurophysiol.   Vol. 107   page: 1313-1324   2012

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  20. Neuropeptide RFRP inhibits the pacemaker activity of extrahypothalamic GnRH neurons Reviewed International journal

    Umatani C, Abe H, Oka Y

    Society for Neuroscience Abstract Viewer and Itinerary Planner   Vol. 42   2012

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    Publishing type:Research paper (international conference proceedings)  

    Other Link: http://orcid.org/0000-0002-3482-3051

  21. Neural mechanisms of female sexual preference in medaka Reviewed International journal

    Okuyama T, Yokoi S, Abe H, Taniguchi Y, Okubo K, Kamei Y, Shimada A, Naruse K, Takeda H, Oka Y, Kubo T, Takeuchi H

    Society for Neuroscience Abstract Viewer and Itinerary Planner   Vol. 42   2012

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    Publishing type:Research paper (international conference proceedings)  

    Other Link: http://orcid.org/0000-0002-3482-3051

  22. Mechanisms of neuromodulation by a non-hypophysiotropic GnRH system controlling motivation of reproductive behavior in the teleost brain. Invited Reviewed

    Abe, H. and Oka, Y.

    Journal of Reproduction and Development.   Vol. 57 ( 6 ) page: 665-674   2011

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    Authorship:Lead author, Corresponding author   Language:English  

  23. Neuromodulatory effect of GnRH on the synaptic transmission of the olfactory bulbar neural circuit in goldfish, Carassius auratus Reviewed

    Kawai, T., Abe, H., Akazome, Y., and Oka, Y.

    J. Neurophysiol   Vol. 104   page: 3540-3550   2010

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  24. Electrophysiological analysis of the inhibitory effects of FMRFamide-like peptides on the pacemaker activity of gonadotropin-releasing hormone neurons. Reviewed

    Saito, T.H., Nakane, R., Akazome, Y., Abe, H., and Oka, Y.

    J. Neurophysiol.   Vol. 104   page: 3518-3529   2010

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  25. Regular pacemaker activity characterizes gonadotropin-releasing hormone 2 neurons recorded from green fluorescent protein-transgenic medaka Reviewed

    Kanda, S., Nishikawa, K., Karigo, T., Okubo, K., Isomae, S., Abe, H., Kobayashi, D., and Oka, Y.

    Endocrinology   Vol. 151   page: 695-701   2010

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  26. Primary culture of the isolated terminal nerve - gonadotrophin-releasing hormone neurones derived from adult teleost (dwarf gourami, Colisa lalia) brain for the study of peptide release mechanisms. Reviewed

    Abe, H. and Oka, Y.

    J. Neuroendocrinol.   Vol. 21   page: 489 - 505   2009

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1365-2826.2009.01866.x

  27. Calcium oscillations in the olfactory nonsensory cells of the goldfish, Carassius auratus. Reviewed

    Kawai, T., Abe, H., Wakabayashi, K., and Oka, Y.

    Biochimica et Biophysica Acta   Vol. 1790   page: 1681-1688   2009

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  28. Mechanism of rapid action of estrogen in LHRH neurons: A possible role of G-protein coupled receptor 30 in GT1-7 cells. Reviewed International coauthorship

    Noel, S.D., Keen, K.L., Abe, H., Frost, S.I., Filado, E.J., Terasawa, E.

    Front. Neuroendcrinol   Vol. 27   page: 70 - 71   2008

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.yfrne.2006.03.147

  29. Rapid action of estrogen on intracellular calcium oscillations in primate LHRH-1 neurons. Reviewed International coauthorship

    Abe, H., Keen, K.L. and Terasawa, E

    Endocrinology   Vol. 149   page: 1155 - 1162   2008

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/en.2007-0942

  30. Primary culture of the isolated terminal nerve - gonadotropin releasing hormone neurons derived from adult teleost brain and their electrophysiological properties Reviewed

    Abe H, Oka Y

    Society for Neuroscience Abstract Viewer and Itinerary Planner   Vol. 38   2008

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    Language:English   Publishing type:Research paper (scientific journal)  

    Other Link: http://orcid.org/0000-0002-3482-3051

  31. Isolated primary culture system of terminal nerve GnRH neurons and their membrane excitabilities

    Abe Hideki, Oka Yoshitaka

    Proceedings of Annual Meeting of the Physiological Society of Japan   Vol. 2008 ( 0 ) page: 137 - 137   2008

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:PHYSIOLOGICAL SOCIETY OF JAPAN  

    The terminal nerve (TN)-gonadotropin releasing hormone (GnRH) neurons are suggested to release GnRH peptides from widely branched neural processes and the somatodendritic regions, depending on their firing activity, and the released GnRH is suggested to exert their neuromodulatory action on GnRH receptors located on various target neurons.To address questions on how electrical activities of the TN-GnRH neuronal somata affect GnRH release from various neuronal compartments, we established the primary culture of TN-GnRH neurons, which will enable simultaneous recordings of various physiological signals from various compartments of a single TN-GnRH neuron.The whole brain of an adult freshwater fish (dwarf gourami) was dissected out, and the TN-GnRH neurons were sucked out from the brain with the aid of a suction pipette and plated on a coverslip in culture medium. The isolated TN-GnRH neurons could be cultured up to two weeks. During the culture, the neurons grew both axon- and dendrite-like neurites. Although the cultured neurons had relatively shallow resting membrane potentials and had no spontaneous discharge, unlike the neurons in situ, they showed subthreshold spontaneous membrane potential oscillations and could be induced to fire in phasic or tonic patterns. In addition, stimulus-induced exocytotic events could be observed at the soma and neurites by using fluorescent dye, FM1-43. Therefore, isolated culture of TN-GnRH neuron will open up a wide range of possibilities for studying cellular mechanism of the exocytosis and generation of spontaneous firing activity of peptidergic neurons. <b>[J Physiol Sci. 2008;58 Suppl:S137]</b>

    DOI: 10.14849/psjproc.2008.0.137.1

    CiNii Research

  32. Neuromodulatory functions of terminal nerve-GnRH neurons. Invited Reviewed

    Abe, H. and Oka, Y.

    Fish Physiology Vol. 25, Sensory Systems Neuroscience     page: 455-503   2007

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    Authorship:Lead author   Language:English   Publishing type:Part of collection (book)  

  33. Isolated primary culture of the terminal nerve (TN)-GnRH neurons derived from the brain of a tropical teleost Reviewed

    Hideki Abe, Yoshitaka Oka

    NEUROSCIENCE RESEARCH   Vol. 58   page: S222 - S222   2007

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER IRELAND LTD  

    Web of Science

  34. Isolated primary culture of the terminal nerve-GnRH neurons derived from the brain of a tropical freshwater fish, the dwarf gourami, Colisa lalia Reviewed

    Hideki Abe, Koichiro Baba, Rei Ozaki, Yoshitaka Oka

    ZOOLOGICAL SCIENCE   Vol. 23 ( 12 ) page: 1188 - 1188   2006.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ZOOLOGICAL SOC JAPAN  

    Web of Science

  35. Firing Pattern and Rapid Modulation of Activity by Estrogen in Primate LHRH-1 Neurons. Reviewed International coauthorship

    Abe, H. and Terasawa, E.

    Endocrinology   Vol. 146   page: 4312 - 4320   2005

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/en.2005-0435

  36. Ligand-induced dynamic rearrangement of the intracellular dimeric conformation of metabotropic glutamate receptor 1α. Reviewed

    Tateyama, M., Abe, H., Nakata, H., Saito, O. and Kubo, Y

    Nature Structural & Molecular Biology   Vol. 11   page: 637 - 642   2004

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nsmb770

  37. Distribution of Regulator of G protein signaling 8 (RGS8) protein in the cerebellum. Reviewed

    Saitoh, O., Masuho, I., Itoh, M., Abe, H., Komori, K. and Odagiri, M.

    The CEREBELLUM   Vol. 2   page: 154 - 160   2003

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/14734220309409

  38. Functional identification of Gd3+ binding site of metabotropic glutamate receptor 1α. Reviewed

    Abe, H., Tateyama, M. and Kubo, Y.

    FEBS letter   Vol. 27356   page: 1 - 6   2003

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0014-5793(03)00569-6

  39. Effects of co-expression with Homer isoforms on the function of metabotropic glutamate receptor 1α. Reviewed

    Abe, H., Misaka, T., Tateyama, M. and Kubo, Y.

    Mol. Cell. Neurosci.   Vol. 23   page: 157 - 168   2003

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S1044-7431(03)00052-6

  40. Mechanisms of the modulation of pacemaker activity by GnRH peptides in the terminal nerve-GnRH neurons Reviewed

    Abe, H. and Oka, Y.

    Zool. Sci.   Vol. 19   page: 111 - 128   2002

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2108/zsj.19.111

  41. RGS8 protein is distributed in dendrites and cell body of cerebellar Purkinje cell. Reviewed

    Itoh, M., Odagiri, M., Abe, H. and Saitoh, O.

    Biochem. Biophys. Res. Commun.   Vol. 287   page: 223 - 228   2001

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1006/bbrc.2001.5489

  42. Modulation of pacemaker activity by salmon gonadotropin-releasing hormone (sGnRH) in terminal nerve (TN)-GnRH neurons Reviewed

    Abe, H. and Oka, Y.

    J. Neurophysiol.   Vol. 83   page: 3196 - 3200   2000

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/jn.2000.83.5.3196

  43. Characterization of K+ currents underlying pacemaker potentials of fish gonadotropin-releasing hormone cells. Reviewed

    Abe, H. and Oka, Y.

    J. Neurophysiol.   Vol. 81   page: 643 - 653   1999

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/jn.1999.81.2.643

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Books 1

  1. 魚類学の百科事典

    阿部秀樹, 一般社団法人日本魚類学会( Role: Contributor ,  生殖行動の神経ペプチドによる制御)

    丸善出版  2018.10  ( ISBN:4621303171

MISC 6

  1. キンギョ嗅上皮におけるカルシウム振動

    河合喬文, 阿部秀樹, 岡良隆

    日本動物学会大会予稿集   Vol. 79th   page: 88   2008.8

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    Language:Japanese  

    J-GLOBAL

  2. Neuromodulatory action of GnRH peptide on the olfactory responses in the goldfish

    Takafumi Kawai, Eisthen Heather, Estep Chad, Hideki Abe, Yoshitaka Oka

    ZOOLOGICAL SCIENCE   Vol. 23 ( 12 ) page: 1188 - 1189   2006.12

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:ZOOLOGICAL SOC JAPAN  

    Web of Science

  3. 代謝型グルタミン酸受容体の構造と生理機能 (特集 Gタンパク質共役受容体と脳機能)

    阿部 秀樹, 立山 充博, 久保 義弘

    遺伝子医学   Vol. 7 ( 2 ) page: 191-194   2003.6

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    Language:Japanese  

  4. 神経伝達機構の分子的記述 2 代謝型グルタミン酸受容体の分子構築と機能制御機構

    阿部秀樹, 久保義弘

    医学のあゆみ   Vol. 202 ( 13 ) page: 1023 - 1026   2002.9

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    Language:Japanese  

    J-GLOBAL

  5. Physiology of GnRH neurons and modulation of their activities by GnRH. Invited Reviewed

    Oka, Y. and Abe, H.

    In: "Neuroplasticity, Development, and Steroid Hormone Action" (ed. by R. Handa, S. Hayashi, E. Terasawa, and M. Kawata)     page: 191-203   2002

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    Language:English  

  6. 神経疾患とカルシウム 細胞外カルシウムが神経細胞の機能におよぼす作用

    宮下知之, 阿部秀樹, 久保義弘

    Clin Calcium   Vol. 11 ( 11 ) page: 1425 - 1431   2001.11

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    Language:Japanese  

    J-GLOBAL

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Presentations 72

  1. TTX類縁体5,6,11-trideoxyTTXに対するミドリフグ嗅細胞匂い応答のカルシウムイメージング

    鈴木偉久・西川俊夫・阿部秀樹

    第14回水生動物の行動と神経系シンポジウム  2022.12.3 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

  2. ミドリフグの鼻は本当にTTX類縁体の匂いを感知しているのか?:単一細胞カルシウムイメージングでしらべてみた

    鈴木偉久・中東亮太・安立昌篤・西川俊夫・阿部秀樹

    第7回ユニーク会  2022.9.21 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋大学  

  3. ミドリフグ嗅細胞におけるTTXアナログに対する匂い応答

    鈴木偉久・中東亮太・安立昌篤・西川俊夫・阿部秀樹

    日本動物学会第93回大会  2022.9.10  日本動物学会

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:早稲田大学  

  4. ミドリフグは無毒なTTX 類縁体をどのように感じるのか?

    鈴木偉久・中東亮太・安立昌篤・西川俊夫・阿部秀樹

    令和4年度日本水産学会春季大会「オンライン」ナイトポスターセッション  2022.3.26  日本水産学会若手の会

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    Event date: 2022.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:オンライン  

  5. 有毒フグは無毒なTTX 類縁体をどのように感じるのか?

    鈴木偉久・野口能寿・中東亮太・安立昌篤・山本直之・西川俊夫・阿部秀樹

    第6回”ユニーク会”  2021.9.10 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン開催  

  6. 神経ペプチド放出特異的可視化のためのトランスジェニックメダカ

    阿部秀樹・梶浦真司

    日本動物学会第92回大会  2021.9  日本動物学会

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン開催  

  7. 成魚嗅上皮へのGCaMP6s in vivo 電気穿孔によって可視化したミドリフグ嗅細胞の匂い応答

    鈴木偉久・阿部 秀樹

    日本動物学会第92回大会  2021.9  日本動物学会

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン開催  

  8. ミドリフグにおけるTTX類縁体に応答する嗅覚受容細胞の同定響

    鈴木 偉久・中東 亮太・安立 昌篤・山本 直之・西川 俊夫・阿部 秀樹

    日本動物学会第91回大会  2020.9.4  日本動物学会

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    Event date: 2020.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:オンライン  

  9. GnRH3による神経修飾作用がメダカ視機能に及ぼす影響

    大崎 真穂・阿部 秀樹

    日本動物学会第91回大会  2020.9.4  日本動物学会

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    Event date: 2020.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:オンライン  

  10. 異なる配偶システムを生み出す脳内バソトシン・イソトシン系の比較

    福田和也・椋田崇生・川口将史・阿部秀樹・山本直之

    第13回水生動物の行動と神経系シンポジウム 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:中部大学名古屋キャンパス  

  11. 脳内GnRH3ニューロンにおけるペプチド放出のライブイメージング、第13回水生動物の行動と神経系シンポジウム

    梶浦真司・木山純平・阿部秀樹

    第13回水生動物の行動と神経系シンポジウム 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:中部大学名古屋キャンパス  

  12. ミドリフグ(Dichotomyctere nigroviridis)における、TTX類に対する嗅覚性誘引行動

    鈴木偉久・野口能寿・中東亮太・安立昌篤・山本直之・西川俊夫・阿部秀樹

    第13回水生動物の行動と神経系シンポジウム 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:中部大学名古屋キャンパス  

  13. 異なる配偶システムを生み出す脳内バソトシン・イソトシン系の比較研究

    福田和也・椋田崇生・川口将史・阿部秀樹・山本直之

    日本動物行動学会第38回大会 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪市立大学杉本キャンパス  

  14. GnRH3-SynaptopHluorinメダカ ex vivo脳標本から記録されたGnRH3ニューロンからの自発的開口放出活動

    阿部秀樹・木山純平・梶浦真司

    日本動物学会第90回大阪大会  日本動物学会

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    Event date: 2019.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪市立大学杉本キャンパス  

  15. ミドリフグ(Tetraodon nigroviridis)における、TTX類に対する嗅覚性誘引行動

    鈴木偉久・中東亮太・安立昌篤・山本直之・西川俊夫・阿部 秀樹

    日本動物学会第90回大阪大会  日本動物学会

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    Event date: 2019.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪市立大学杉本キャンパス  

  16. 視覚実験系モデルとして有望なマハゼの視覚路の解明

    萩尾華子・川口将史・佐藤萌・阿部秀樹・山本直之

    平成31年度日本水産学会春期大会  日本水産学会

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    Event date: 2019.3 - 2919.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京海洋大学品川キャンパス  

  17. GnRH3による神経修飾作用がメダカ視機能に及ぼす影響

    大崎真穂・阿部秀樹

    平成30年度日本動物学会中部支部大会  日本動物学会中部支部

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    Event date: 2018.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:名古屋大学  

  18. トランスジェニックメダカを用いた単一ペプチドニューロンからの開口放出のタイムラプスイメージング

    木山純平・梶浦真司・阿部秀樹

    平成30年度日本動物学会中部支部大会  日本動物学会中部支部

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    Event date: 2018.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:名古屋大学  

  19. トランスジェニックメダカを用いた単一ペプチドニューロンからの開口放出のタイムラプスイメージング

    木山純平・梶浦真司・阿部秀樹

    日本動物学会第89回札幌大会  日本動物学会

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    Event date: 2018.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:札幌コンベンションセンター  

  20. Ascending visual pathways to the telencephalon in the medaka, a percomorph fish.

    Hagio, H., Kachi, H., Abe, H., and Yamamoto, N.

    The 24th Japanese medaka and zebrafish meeting  小型魚類研究会

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    Event date: 2018.8

    Language:English   Presentation type:Poster presentation  

    Venue:名古屋大学  

  21. Live cell imaging of peptide release from single peptidergic neuron using transgenic medaka

    Kiyama, J., Kajiura, S., and Abe, H.

    The 24th Japanese medaka and zebrafish meeting  小型魚類研究会

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    Event date: 2018.8

    Language:English   Presentation type:Poster presentation  

    Venue:名古屋大学  

  22. クサフグ(Takifugu niphobles)におけるフグ毒類縁体に対する嗅覚感知機構

    野口能寿, 榊原良, 佐竹佳樹, 安立昌篤, 西川俊夫, 山本直之, 阿部秀樹

    平成30年度日本水産学会春期大会  2018.3.26 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Poster presentation  

  23. 光刺激により賦活化した硬骨魚類の中枢視覚路の組織化学的解析

    萩尾華子, 加地秀, 佐藤萌, 阿部秀樹, 山本直之

    日本水産学会大会講演要旨集  2018.3.26 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  24. テトロドトキシンのフグ誘引活性の解明を目的とした類縁体の合成研究

    中東亮太, 安立昌篤, 野口能寿, 山本直之, 阿部秀樹, 西川俊夫

    日本農芸化学会大会講演要旨集(Web)  2018.3.5 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  25. 蛍光デキストランを利用した匂い刺激に応答するクサフグ嗅上皮細胞の同定

    野口能寿・榊原良・佐竹佳樹・安立昌篤・西川俊夫・山本直之・阿部秀樹

    日本動物学会第88回富山大会  日本動物学会

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    Event date: 2017.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:富山県民会館  

  26. キンギョ培養終神経GnRH3ニューロンにおける局所開口放出に関わるCa2+流入経路

    河南遙香・阿部秀樹

    日本動物学会第88回富山大会  日本動物学会

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    Event date: 2017.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:富山県民会館  

  27. 行動の変化に伴う神経回路の修飾を覗き見したい

    阿部秀樹

    第三回ユニークな少数派実験動物を使う若手が最先端アプローチを勉強する会 

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    Event date: 2017.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡崎コンファレンスセンター  

  28. 硬骨魚類の脳内視覚路と光刺激による活性化

    萩尾華子, 佐藤萌, 阿部秀樹, 山本直之

    日本水産学会大会講演要旨集  2017.3.26 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  29. Can grass puffersifh (Takifugu niphobles) sniff “Tetrodotoxins”? International conference

    Noguchi, Y., Sakakibara, R., Satake, Y., Adachi, M., Yamamoto, N., Nishikawa, T., and Abe, H.

    The 22nd International Congress of Zoology and The 87th Meeting of The Zoological Society of Japan Joint Events in Okinawa 

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    Event date: 2016.11

    Language:English   Presentation type:Poster presentation  

  30. 条鰭類の視覚路の進化と視覚路の機能に関する研究

    萩尾華子・佐藤萌・阿部秀樹・山本直之

    第二回ユニークな少数派実験動物を使う若手が最先端アプローチを勉強する会 

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    Event date: 2016.8

    Language:Japanese   Presentation type:Poster presentation  

    Venue:岡崎コンファレンスセンター  

  31. クサフグはTTX を匂いとして感知できるか?

    野口能寿・榊原良・佐竹直樹・安立昌篤・西川俊夫・山本直之・阿部秀樹

    第二回ユニークな少数派実験動物を使う若手が最先端アプローチを勉強する会 

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    Event date: 2016.8

    Language:Japanese   Presentation type:Poster presentation  

    Venue:岡崎コンファレンスセンター  

  32. メダカ視蓋ニューロン視覚応答特性のin vivo記録

    後藤友里・阿部秀樹

    第11回水生動物の行動と神経系シンポジウム 

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    Event date: 2015.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜市立大学医学部  

  33. 硬骨魚類における中枢視覚路の進化

    萩尾華子・佐藤萌・阿部秀樹・山本直之

    第11回水生動物の行動と神経系シンポジウム 

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    Event date: 2015.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜市立大学医学部  

  34. Evolution of the ascending visual pathways in teleosts International conference

    Hagio, H. Satou, M. Abe, H. and Yamamoto, N.

    45rd Annual Meetings, Society for Neuroscience  Society for Neuroscience

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    Event date: 2015.10

    Language:English   Presentation type:Poster presentation  

    Venue:Chicago   Country:United States  

  35. Neuromodulation of retino-tectal neurotransmission via extrahypothalamic GnRH neurons International conference

    Umatani, C. Misu, R. Oishi, S. Abe, H. and Oka, Y.

    45rd Annual Meetings, Society for Neuroscience  Society for Neuroscience

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    Event date: 2015.10

    Language:English   Presentation type:Poster presentation  

    Venue:Chicago   Country:United States  

  36. 脱分極刺激によって生じたキンギョ培養終神経GnRH3ニューロンにおける分泌小胞移動変化

    志賀将雄・阿部秀樹

    日本動物学会第86回大会  日本動物学会

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:朱雀メッセ新潟コンベンションセンター  

  37. In vitro culture system of goldfish terminal nerve GnRH3 peptidergic neurons for studying peptide release and their neuromodulation mechanisms

    Abe, H. and Shiga, M.

    2015.7 

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    Event date: 2015.7

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  38. .Neuromodulation in fish visual system via terminal nerve GnRH neurons

    Umatani, C., Misu, R., Oishi, S., Abe, H., Oka, Y.

    2015.7 

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    Event date: 2015.7

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  39. 繁殖行動を制御する脳内ペプチドニューロンによる神経修飾機構を探るためのキンギョ嗅球・終神経GnRHニューロン共培養系

    志賀将雄, 山本直之, 阿部秀樹

    日本水産学会大会講演要旨集  2014.9.19 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  40. キンギョ培養終神経GnRHニューロンに遺伝子導入した開口放出センサータンパク質

    阿部秀樹, 志賀雅将

    日本動物学会大会予稿集  2014.8.7 

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    Event date: 2014.8

    Language:Japanese   Presentation type:Oral presentation (general)  

  41. Neuromodulatory effects of terminal nerve GnRH neurons in the fish visual system International conference

    Umatani C, Abe H, Oka Y

    International Congress for Neuroethology  2014.7 

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    Event date: 2014.7 - 2014.8

    Language:English  

    Venue:Sapporo   Country:Japan  

  42. A neural mechanism underlying mating preferences for familiar individuals in medaka fish International conference

    Okuyama, T., Yokoi, S., Abe, H., Isoe, Y., Suehiro, Y., Imada, H., Tanaka, M., Kawakami, K., Yuba, S., Taniguchi, Y., Kamei, Y., Okubo, K., Shimada, A., Naruse, K., Takeda, H., Oka, Y., Kubo, T., Takeuchi, H.

    2nd Medaka Strategic Meeting  2014.4 

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    Event date: 2014.4

    Language:English  

    Venue:Seville   Country:Spain  

  43. 魚類の季節繁殖を制御する分子機構―2 血管嚢はサクラマスの季節センサーである

    飯郷雅之, 小菅克弥, 武田維倫, 中根右介, 池上啓介, 前田遼介, 千賀琢己, 阿見彌典子, 天野勝文, 山本直之, 阿部秀樹, 吉村崇

    日本水産学会大会講演要旨集  2014.3.27 

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    Event date: 2014.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  44. Neural mechanism underlying socially-regulated female mating receptivity in medaka fish

    Okuyama, T., Yokoi, S., Abe, H., Isoe, Y., Suehiro, Y., Imada, H., Kawasaki, T., Yuba, S., Taniguchi, Y., Kamei, Y., Okubo, K., Shimada, A., Naruse, K., Takeda, H., Oka, Y., Kubo, T., Takeuchi, H.

    2013.12 

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    Event date: 2013.12

    Language:English  

    Country:Japan  

  45. 神経修飾ペプチドの放出および放出されたペプチドによる神経修飾機構解析のためのキンギョ終神経GnRHニューロン・嗅球構成細胞共培養系

    志賀将雄・阿部秀樹

    第10回水棲動物の行動と神経系シンポジウム  2013.11.30  水棲動物の行動と神経系シンポジウム

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    Event date: 2013.11 - 2013.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鹿児島大学   Country:Japan  

  46. Morphological analysis of the early development of GnRH neuron systems in the EGFP-expressing transgenic medaka lines International conference

    Takahashi A., Sadiqul I., Akazome Y., Abe H., Okubo K., Oka Y.

    43rd Annual Meetings, Society for Neuroscience 

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    Event date: 2013.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  47. Ascending general visceral sensory pathways from the commissural nucleus of Cajal in goldfish International conference

    Uezono S., Yamada Y., Abe H. and Yamamoto N.

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    Event date: 2013.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  48. サクラマスの血管嚢は季節繁殖を制御する季節センサーである

    池上啓介, 飯郷雅之, 中根右介, 前田遼介, 千賀琢己, 阿部秀樹, 山本直之, 吉村崇

    時間生物学  2013.10.30 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Oral presentation (general)  

  49. メダカの配偶者選択の分子神経基盤

    奥山輝大,横井佐織,阿部秀樹,磯江泰子,末廣勇司,今田はるか,島田敦子,川崎隆史,弓場俊輔,谷口善仁,亀井保博,田中実,成瀬清,武田洋幸,岡良隆,久保健雄,竹内秀明

    日本動物学会第84会大会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  50. 開口放出・神経修飾機構解析を目的としたキンギョ終神経GnRHニューロン初代培養系

    阿部秀樹, 志賀将雄

    日本動物学会第84会大会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  51. 終神経GnRH ニューロンが視覚神経回路に及ぼす作用の解析

    馬谷千恵,阿部秀樹,岡良隆

    日本動物学会第84会大会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  52. 開口放出・神経修飾機能解析を目的としたキンギョ終神経GnRHニューロン初代培養系

    阿部秀樹, 志賀将雄

    日本動物学会大会予稿集  2013.8.12 

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    Event date: 2013.8

    Language:Japanese   Presentation type:Oral presentation (general)  

  53. 終神経GnRHニューロンが視覚神経回路に及ぼす作用の解析

    馬谷千恵, 阿部秀樹, 岡良隆

    日本動物学会大会予稿集  2013.8.12 

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    Event date: 2013.8

    Language:Japanese   Presentation type:Oral presentation (general)  

  54. メダカの配偶者選択の分子神経基盤

    奥山輝大, 横井佐織, 阿部秀樹, 磯江泰子, 末廣勇司, 今田はるか, 島田敦子, 川崎隆史, 弓場俊輔, 谷口善仁, 亀井保博, 田中実, 成瀬清, 武田洋幸, 岡良隆, 久保健雄, 竹内秀明

    日本動物学会大会予稿集  2013.8.12 

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    Event date: 2013.8

    Language:Japanese   Presentation type:Oral presentation (general)  

  55. 遺伝子改変メダカを用いた黄体形成ホルモン(LH)放出の中枢制御機構の解析

    近藤千香,苅郷友美,相川雅人,神田真司,赤染康久,大久保範聡,阿部秀樹,岡良隆

    日本動物学会関東支部第65会大会 

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    Event date: 2013.3

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  56. Electrophysiological and Morphological Analysis of Kiss1 Neurons in Trasgenic Medaka, Oryzias latipes International conference

    [Shimada, H.][Kanda, S.][Akazome, Y.][Abe, H.][Okubo, K.][Oka, Y]

    2nd world conference kisspeptin; signaling in the brain 

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    Event date: 2012.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  57. Neuropeptide RFRP inhibits the pacemaker activity of terminal nerve GnRH neurons International conference

    Umatani, C., Abe, H., Oka, Y.

    42nd Annual Meetings, Society for Neuroscience 

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    Event date: 2012.10

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  58. Neuro-neuronal connections among the cluster of terminal nerve Gonadotropin Releasing Hormone (GnRH) peptidergic neurons: A model for studying the synchronization of peptidergic neurons International conference

    Abe, H., Nishikawa, H., Suenami, S., Oka, Y.

    42nd Annual Meetings, Society for Neuroscience 

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    Event date: 2012.10

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  59. Neural mechanisms of female sexual preference in medaka International conference

    3.Okuyama, T., Yokoi, S., Abe, H., Taniguchi, Y., Okubo, K., Kamei, Y., Shimada, A., Naruse, K., Takeda, H., Oka, Y., Kubo, T., Takeuchi, H.

    42nd Annual Meetings, Society for Neuroscience 

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    Event date: 2012.10

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  60. Neuro-neuronal connections among the cluster of terminal nerve GnRH peptidergic neurons

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    Event date: 2012.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  61. Neural mechanisms of female sexual preference in medaka, Oryzias latipes

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    Event date: 2012.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  62. Neuropeptide RFRP inhibits the pacemaker activity of terminal nerve GnRH neurons

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    Event date: 2012.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  63. Burst induction mediated by cholinergic input in terminal nerve -gonadotropin releasing hormone neurons

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    Event date: 2012.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  64. Homer分子が代謝型グルタミン酸受容体の応答持性に及ぼす作用

    阿部秀樹, 久保義弘

    神経化学  2001.9.1 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  65. 終神経GnRH細胞ペースメーカー活動のGnRHによる二相性修飾

    阿部秀樹, 岡良隆

    日本神経科学大会プログラム・抄録集  1999.7.6 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  66. 終神経GnRH細胞のペースメーカー活動はGnRHにより二相性に修飾される

    阿部秀樹, 岡良隆

    日本動物学会大会予稿集  1999.9.27 

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  67. 終神経GnRHニューロンペースメーカ活動に対するFMRFamideペプチドの抑制性作用に関する電気生理学的解析

    齊藤健, 阿部秀樹, 岡良隆

    生化学  2008 

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    Language:Japanese   Presentation type:Oral presentation (general)  

  68. 終神経GnRHニューロンへのFMRFamideペプチドの過分極性作用に関する電気生理学的解析

    齊藤健, 阿部秀樹, 岡良隆

    日本動物学会大会予稿集  2008.8.20 

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  69. 終神経GnRHニューロンにおける規則的発火活動と細胞内Ca<sup>2+</sup>濃度の動態

    尾崎令, 阿部秀樹, 岡良隆

    日本動物学会大会予稿集  2008.8.20 

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  70. 単離培養した終神経GnRHニューロンから記録した電気活動

    阿部秀樹, 岡良隆

    日本動物学会大会要旨集  2007.8.31 

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  71. 単一細胞電気穿孔による終神経GnRHニューロンへの外来分子導入法

    入江高行, 尾崎令, 阿部秀樹, 岡良隆

    日本動物学会大会予稿集  2008.8.20 

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  72. Homer分子が代謝型グルタミン酸受容体の応答特性に及ぼす作用

    阿部秀樹, 久保義弘

    日本神経科学大会プログラム・抄録集  2001.9.26 

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Research Project for Joint Research, Competitive Funding, etc. 1

  1. 武田科学振興財団ライフサイエンス研究奨励助成

    2012.7 - 2014.5

KAKENHI (Grants-in-Aid for Scientific Research) 14

  1. Exocytosis and Neuromodulation mechanism of GnRH3 peptide in the brain

    Grant number:19K06762  2019.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

  2. Elucidation of recognition mechanism of tetrodotoxin by puffer fish

    Grant number:17K19195  2017.6 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Challenging Research (Exploratory)  Challenging Research (Exploratory)

    Nishikawa Toshio

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    Authorship:Coinvestigator(s) 

    Because of the strong toxicity of tetrodotoxin (TTX), pufferfish uses TTX as a protective substance. On the other hand, there have been interesting reports that pufferfish are attracted to TTX. We thus first attempted to confirm that the TTX is actually sensed by the pufferfish olfactory organ by measuring an olfactory electrogram (EOG: electric field potential change generated when the olfactory epithelium is stimulated with an odorant). Unexpectedly, a strong EOG response was observed for a non-toxic analog of TTX rather than toxic TTX. We then synthesized several related compounds of the TTX analog for structure-activity relationship studies, and attempted behavior experiment using pufferfish, and to identify attractive olfactory cell species that receive the TTX analog.

  3. Optical analysis of the transport and exocytosis of neuropeptide and their neuromodulatory actions

    Grant number:16K07435  2016.4 - 2019.3

    Abe Hideki

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    Authorship:Principal investigator 

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    Using the terminal nerve GnRH3 peptidergic neurons, we analyzed the release dynamics of single peptidergic neuron and its neuromodulatory action of sensory neural process. We found the localization of intracellular Ca 2+ elevation machinery (L-type Ca 2+ channel in soma and neurites, and N-type Ca 2+ channel in distal neurites) and resultant difference of exocytosis in single peptide neuron, We also established a transgenic medaka that specifically expresses synaptopHluorin, an exocytosis sensor, in GnRH3 neurons, and succeeded in visualizing exocytosis from GnRH3 neurons in the brain. We also found that i.v. application of GnRH peptide exerts an acute modulatory action on optokinertic nystagmus of medaka.

  4. Visual system of fish

    Grant number:15K14803  2015.4 - 2017.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research  Grant-in-Aid for Challenging Exploratory Research

    Yamamoto Naoyuki, ABE Hideki

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

    The present study revealed the presence of a neural pathway: retina-optic tectum-nucleus prethalamicus-dorsal telencephalon. The morphology of the tecto-prethalamic neurons was investigated in detail, since the optic tectum not only receive visual information but also other sensory modalities including lateral line, auditory, somatosensory information. Dendritic arborization of tecto-prethalamic neurons extends to tectal layers where retinal fibers terminate, indicating that the above-mentioned pathway represents an ascending visual pathway to the telenecephalon.
    Searches on the visual centers by the use of neural activity markers gave preliminary results, and further studies will be continued.

  5. Overviewing their dynamics of peptidergic neuromodulation: From single neuron to neuronal circuit

    Grant number:25440166  2013.4 - 2016.3

    Abe Hideki

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\5200000 ( Direct Cost: \4000000 、 Indirect Cost:\1200000 )

    To understand peptide release from single peptidergic neuron and their neuromodulatory actions on their target neuronal circuit, we performed following studies using fish terminal nerve-GnRH3 peptidergic neurons as a model: (i) establishment of the co-culture system of terminal nerve GnRH3 neurons and olfactory bulbar neurons that receive neuromodulatory actions of GnRH3 peptide by dissociating goldfish olfactory bulb. (ii) live-cell imaging of secretory vesicles transfer and their exocytosis from single cultured TN-GnRH3 neuron by exogenous expression of the fluorescent exocytotic sensor proteins, (iii) recording of visual stimuli (static/moving small objects)-induced single neuronal activity in in vivo from the optic tectum of immobilized medaka, and (iv) whole-cell patch-clamp recording of the enhancement of Ca2+-induced K+ current by GnRH3 peptide that will inhibit subventricular neuronal activities of the optic tectum.

  6. Real-time imaging of excitation-secretioncoupling process from the single peptidergic neuron

    Grant number:23770072  2011.4 - 2013.3

    ABE Hideki

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    To understand fine tuning mechanisms of the central nervous system by peptidergic neurons, we investigated the excitation-secretion relationship of single peptidergic neuron using a primary culture system of isolated fish terminal nerve (TN)-gonadotropin releasing hormone (GnRH) neuron and gene transfer of exogenous genes by single cell electroporation. As a result, we enabled measurement of the movement of secretory vesicles and their exocytotic events from the subcellular region of single peptidergic neuron. We also analyzed the ionic mechanisms of the firing pattern control of TN-GnRH neurons that are the origin of exocytosis of GnRH peptide.

  7. 単離培養GnRHニューロンを用いたペプチド開口放出動態の細胞生理学的解析

    2008.4 - 2011.3

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

  8. ペプチドニューロンによる神経回路機能修飾の分子・細胞メカニズム

    2006.4 - 2008.3

    科学研究費補助金  特定領域研究

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    Authorship:Coinvestigator(s) 

  9. 多機能性GnRHペプチド神経系の生物機能を包括的に理解する

    2006.4 - 2008.3

    科学研究費補助金  基盤研究(B)

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    Authorship:Coinvestigator(s) 

  10. スライス培養系を用いたペプチド神経修飾細胞からのペプチド分泌機構の研究

    2005.4 - 2008.3

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

  11. スライス培養系を用いたペプチド神経修飾細胞からのペプチド分泌機構の研究

    Grant number:17770059  2005 - 2007

    文部科学省  科学研究費補助金(若手研究(B))  若手研究(B)

    阿部 秀樹

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    Authorship:Principal investigator  Grant type:Competitive

    脳内に極めて広く投射して広範な脳部位で神経修飾作用を持つと考えられる終神経(TN)-GnRH系について、「TN-GnRHニューロン細胞体における自発活動が広範囲に分枝した神経突起末端での細胞内Ca^<2+>濃度変化、ひいてはペプチド放出にいかなる影響を与えるのか」を明らかにするために、TN-GnRHニューロンの特徴的形態を培養下で再現し、電気生理、各種イメージング、分子生物学的手法などを有機的に融合して多面的に上記疑問に迫るという研究の着想に至った。
    本年度は昨年度培養方法を確立したTN-GnRHニューロンの単離培養系を使用して、
    1.単離培養環境下におけるTN-GnRHニューロンの神経突起伸長パターン・軸索-樹状突起分化に関する形態学的解析を行い、(1)生体内における同ニューロンと同様の神経突起伸長パターンが培養環境下で再現されることや(2)軸索-樹状突起分化、(3)単離TN-GnRHニューロン同士が培養環境下で相互結合を示すことが明らかとなった。
    2.また、同ニューロンの電気生理学的特性を解析したところ、(1)従来研究に用いてきた急性脳ブロック標本で観察された規則的自発発火活動が消失し、やや脱分極した状態で閾値下の膜電位振動を示すことが明らかとなった。(2)しかしながら過分極性に直流電流を通電した状態でパルス状に脱分極刺激を行うと、一過性、または持続性に活動電位が誘発され...

  12. 行動の動機付けの神径機構に関するイメージングとテレメトリーを用いた研究

    Grant number:17657027  2005 - 2006

    文部科学省  科学研究費補助金(萌芽研究)  萌芽研究

    岡良隆, 赤染康久, 阿部秀樹, 赤染 康久, 阿部 秀樹

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Competitive

    一般に中枢神経系における情報処理は、ニューロン間のシナプス結合によって形成される神経回路において正確なアルゴリズムにしたがって行われる。一方、動物は一般に外界からの入力に対して常に一定した応答を示すのではなく、多様な環境の変化に対応して適応的かつ合目的的に柔軟に応答する能力を備えている。我々は、このとき神経回路機能に柔軟性を持たせる重要な役割を演じているのがペプチド神経系であると考えている。申請者の従来の研究結果から、終神経系において産生されるペプチド、ゴナドトロピン放出ホルモン(GnRH)は、実際にはホルモンとしては働かず脳内の広範囲に神経突起を投射し、そこからGnRHを放出して神経修飾作用を持つことが示唆されている。さらに、GnRHによる神経修飾作用は、動物行動の動機付け調節という重要な脳内機構の基礎であろうと考えられる行動学的証拠を得つつある。そこで本研究では、遺伝子導入を用いた特異的ニューロン破壊やテレメトリーといった先端技術を用いて動機付け調節の神経機構の解明に迫ることを目的とした。本年度は、行動中の動物の終神経GnRHニューロンからのテレメトリーを用いたニューロン活動記録を行うための装置の開発とin vitro脳標本を用いた予備実験を行った。研究協力者である工藤雄一博士が従来のテレメトリー装置をさらに軽量化し、自重1グラム以下のデバイスの作成に成功した。そこで、ド...

  13. ペプチドニューロンによる神経回路機能修飾の細胞メカニズム

    Grant number:17023016  2005

    文部科学省  科学研究費補助金(特定領域研究)  特定領域研究

    岡良隆, 赤染康久, 阿部秀樹, 赤染 康久, 阿部 秀樹

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Competitive

    一般に中枢神経系における情報処理は、ニューロン間のシナプス結合によって形成される神経回路において正確なアルゴリズムにしたがって行われる。一方、動物は一般に外界からの入力に対して常に一定した応答を示すのではなく、多様な環境の変化に対応して適応的かつ合目的的に柔軟に応答する能力を備えている。このとき神経回路機能に柔軟性を持たせる重要な役割を演じているのがペプチド神経系である。申請者の従来の研究結果から、終神経系において産生されるペプチド、ゴナドトロピン放出ホルモン(GnRH)は、実際にはホルモンとしては働かず脳内の広範囲に神経突起を投射し、そこからGnRHを放出して神経修飾作用を持つことが示唆されている。GnRHペプチドによる神経修飾作用を解析するため、まず脳内のGnRH受容体をクローニングしたところ3つの型に分類できる受容体を同定できたので、その脳内分布をin situ hybridizationにより調べた。その結果、糸球体神経核CGにそれらの発現が見られたので、今後CG構成細胞に対するGnRHの神経修飾作用を解析する。一方、GnRHニューロン自身もGnRH受容体を発現していることが単一細胞RT-PCRによっても確認できたことから、GnRHニューロンの放出するGnRHによる傍・自己分泌的な神経修飾作用がGnRHニューロン細胞塊ネットワークに及ぼす影響を解析した。その結果、Nお...

  14. Multidisciplinary studies on the biological functions of peptidergic neuromodulatory systems : from molecules to behavior

    Grant number:15370032  2003 - 2005

    Ministry of Education, Culture, Sports, Science and Technology  Grants-in-Aid for Scientific Research(基盤研究(B))  基盤研究(B)

    Yoshitaka OKA, 松田学, 赤染康久, 阿部秀樹, 松田学, AKAZOME Yasuhisa, ABE Hideki, MATSUDA Manabu

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Competitive

    In the present research project, we obtained the following results concerning the biological functions of peptidergic neuromodulatory systems.1. Real-time simultaneous measurement of exocytotic release of GnRH peptide, electrical activities, and intracellular Ca^<2+> concentrationsAccording to our working hypothesis, changes in the sensory inputs from the environments are processed and fed on to the GnRH neuromodulatory system and modulate the release of GnRH peptides from the neurites of the terminal nerve GnRH neurons, which are distributed widely in the brain. Here, we developed a method...

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Teaching Experience (On-campus) 94

  1. 基礎セミナーA

    2022

  2. 生物学実験

    2022

  3. 資源生物科学実験実習

    2022

  4. 生物学基礎1

    2022

  5. 動物解剖生理学特論

    2022

  6. 生物情報処理演習

    2022

  7. 生物統計学

    2022

  8. 動物生理学1

    2022

  9. First Year Seminar A

    2021

  10. Animal Physiology 1

    2021

  11. Biostatistics Exercise

    2021

  12. Biostatistics

    2021

  13. Animal Morphology and Physology

    2021

  14. 生物学実験

    2021

  15. 資源生物科学実験実習

    2021

  16. 生物学基礎1

    2021

  17. 資源生物科学実験実習

    2020

  18. 生物学実験

    2020

  19. 解剖生理学特論

    2020

  20. 動物生理学特論I

    2020

  21. 生物学基礎I

    2020

  22. Advanced Animal Morphology and Physiology

    2019

  23. Animal Physiology 1

    2019

  24. Advanced Animal Physiology 1

    2019

  25. 基礎セミナー

    2019

  26. Basic Biology 1

    2019

  27. 生物情報処理演習

    2019

  28. 資源生物科学実験実習

    2019

  29. 生物学実験

    2019

  30. 動物生理学特論I

    2018

  31. 解剖生理学特論

    2018

  32. モデル動物学

    2018

  33. 動物生理学I

    2018

  34. 生物情報処理演習

    2018

  35. 基礎セミナー

    2018

  36. 生物学基礎I

    2018

  37. 資源生物科学実験実習

    2018

  38. 生物学実験

    2018

  39. 基礎セミナー

    2017

  40. 生物機能分化学基盤実験

    2017

  41. 生物機能分化学輪講Ⅲ

    2017

  42. 生物機能分化学演習Ⅲ

    2017

  43. モデル動物学

    2017

  44. 動物生理学I

    2017

  45. 生物学基礎I

    2017

  46. 資源生物科学実験実習

    2017

  47. 生物学実験

    2017

  48. 生物機能分化学輪講III

    2016

  49. 生物機能分化学特論III

    2016

  50. 生物機能分化学演習III

    2016

  51. 生物機能分化学基盤実験

    2016

  52. 生物学実験

    2016

  53. 生物学基礎II

    2016

  54. 生物学基礎I

    2016

  55. 基礎セミナーA

    2016

  56. 動物生理学I

    2016

  57. モデル動物学

    2016

  58. 資源生物科学基盤実験実習

    2016

  59. 資源生物科学基盤実験実習

    2015

  60. 生物学基礎II

    2015

  61. 生物機能分化学輪講III

    2015

  62. 生物機能分化学特論III

    2015

  63. 生物機能分化学演習III

    2015

  64. 生物機能分化学基盤実験

    2015

  65. 生物学実験

    2015

  66. 生物学基礎I

    2015

  67. 基礎セミナーA

    2015

  68. 動物生理学I

    2015

  69. モデル動物学

    2015

  70. 生物学実験

    2014

  71. モデル動物学

    2014

  72. 生物機能分化学演習III

    2014

  73. 生物機能分化学輪講III

    2014

  74. 生物機能分化学基盤実験

    2014

  75. 生物機能分化学特論III

    2014

  76. 基礎セミナーA

    2014

  77. 生物学基礎I

    2014

  78. 動物生理学I

    2014

  79. 生物学基礎I

    2013

  80. 基礎セミナーB

    2013

  81. 生物機能分化学特論Ⅲ

    2013

  82. 生物機能分化学輪講III

    2013

  83. 生物学実験

    2013

  84. モデル動物学

    2013

  85. 生物機能分化学演習III

    2013

  86. 生物機能分化学基盤実験

    2013

  87. 基礎セミナーA

    2012

  88. 生物機能分化学輪講III

    2012

  89. 生物機能分化学特論Ⅲ

    2012

  90. 基礎セミナーB

    2012

  91. モデル動物学

    2012

  92. 生物機能分化学基盤実験

    2012

  93. 生物学実験

    2012

  94. 生物機能分化学演習III

    2012

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Teaching Experience (Off-campus) 3

  1. 共通実習Bioclassics

    2012.4 - 2013.3 The University of Tokyo)

  2. 動物形態学実習

    東京大学理学部生物学科)

  3. 共通実習バイオクラシックス

    東京大学理学部)

 

Social Contribution 7

  1. 日本動物学会中部支部公開講演会「今!キンギョがおもしろい」

    Role(s):Presenter, Interviewer, Planner, Organizing member

    日本動物学会中部支部  2021.3

  2. 国際生物学オリンピック2020 (IBO challenge) 理論問題(Animal Biology)出題委員

    Role(s):Informant, Organizing member

    IBO2020長崎大会  2020.8 - 0202.8

  3. 名古屋市立鶴舞中央図書館 サイエンス・カフェ

    2014.10

  4. 静岡サイエンススクール キャリアデザインワークショップ

    2013.11

  5. 山里学童クラブ「ニジマスの解剖」

    2013.3

  6. 名古屋大学大学院生命農学研究科 附属フィールド科学教育研究センター東郷フィールド(附属農場) 「農場講演会」

    2012.10

  7. 岡崎高校SSH体験研修

    2012.8

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