Updated on 2021/03/22

写真a

 
SUGIMOTO Masayuki
 
Organization
Nagoya University Hospital Vascular Surgery Lecturer of hospital
Title
Lecturer of hospital
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Degree 1

  1. 医学博士 ( 2008.3   名古屋大学 ) 

Research Interests 4

  1. Vascular biology

  2. Surgery

  3. Endovascular

  4. Vascular

Research Areas 1

  1. Others / Others  / Vascular surgery

Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    - 2008.3

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    - 1999.3

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    Country: Japan

Professional Memberships 1

  1. 心臓血管外科学会

 

Papers 33

  1. The association between perioperative embolization of hypogastric arteries and type II endoleaks after endovascular aortic aneurysm repair

    Meshii K.

    Journal of Vascular Surgery   Vol. 73 ( 1 ) page: 99 - 107   2021.1

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    Publisher:Journal of Vascular Surgery  

    DOI: 10.1016/j.jvs.2020.04.505

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    Scopus

  2. Low-density vulnerable thrombus/plaque volume on preoperative computed tomography predicts for spinal cord ischemia after endovascular repair for thoracic aortic aneurysm

    Banno H.

    Journal of Vascular Surgery     2021

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    Publisher:Journal of Vascular Surgery  

    DOI: 10.1016/j.jvs.2020.09.026

    Scopus

  3. Endovenous Laser Ablation with and Without Concomitant Phlebectomy for the Treatment of Varicose Veins: A Retrospective Analysis of 954 Limbs

    Kawai Y.

    Annals of Vascular Surgery   Vol. 66   page: 344 - 350   2020.7

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    Publisher:Annals of Vascular Surgery  

    DOI: 10.1016/j.avsg.2019.12.025

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  4. Clinical Comparison Between Early and Late Spontaneous Sac Shrinkage After Endovascular Aortic Aneurysm Repair

    Sugimoto Masayuki, Ikeda Shuta, Kawai Yohei, Tsuruoka Takuya, Niimi Kiyoaki, Kodama Akio, Banno Hiroshi, Komori Kimihiro

    JOURNAL OF VASCULAR SURGERY   Vol. 72 ( 1 ) page: E188 - E189   2020.7

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  5. Suprarenal fixation is associated with worse midterm renal function after endovascular abdominal aortic aneurysm repair compared with infrarenal fixation

    Banno H.

    Journal of Vascular Surgery   Vol. 71 ( 2 ) page: 450 - 456   2020.2

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    Publisher:Journal of Vascular Surgery  

    DOI: 10.1016/j.jvs.2019.03.061

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  6. Long-Term Effectiveness of a Drug-Eluting Stent for Femoropopliteal In-Stent Restenosis: Subanalysis of the Zilver PTX Japan Post-Market Surveillance Study

    Sugimoto M.

    Journal of Endovascular Therapy     2020

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    Publisher:Journal of Endovascular Therapy  

    DOI: 10.1177/1526602820966708

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  7. Proximal Bare Stent May Reduce Bird-Beak Configuration, Which is Associated with Distal Migration of Stent Graft in the Aortic Arch

    Banno H.

    Annals of Vascular Surgery   Vol. 56   page: 108 - 113   2019.4

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    Publisher:Annals of Vascular Surgery  

    DOI: 10.1016/j.avsg.2018.08.081

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  8. Effect of intraoperative division of the left renal vein on the fate of renal function and left renal volume after open repair of para-and juxtarenal aortic aneurysm

    Sugimoto M.

    Circulation Journal   Vol. 83 ( 9 ) page: 1844 - 1850   2019

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    Publisher:Circulation Journal  

    DOI: 10.1253/circj.CJ-19-0383

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  9. Three cases of dorsal metatarsal artery bypass in patients with Buerger disease

    Kodama A.

    Journal of Vascular Surgery Cases and Innovative Techniques   Vol. 4 ( 3 ) page: 185 - 188   2018.9

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    Publisher:Journal of Vascular Surgery Cases and Innovative Techniques  

    DOI: 10.1016/j.jvscit.2018.03.011

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  10. Anatomical suitability of the Gore Excluder iliac branch endoprosthesis in Japanese patients with common iliac aneurysms treated by standard Excluder endografts.

    Sugimoto M, Takahashi N, Niimi K, Kodama A, Banno H, Komori K

    Annals of vascular surgery   Vol. 50   page: 179 - 185   2018.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.avsg.2017.11.071

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    PubMed

  11. Long-term fate of renal function after open surgery for juxtarenal and pararenal aortic aneurysm.

    Sugimoto M, Takahashi N, Niimi K, Kodama A, Banno H, Komori K

    Journal of vascular surgery   Vol. 67 ( 4 ) page: 1042 - 1050   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jvs.2017.07.121

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  12. Impact of renal arterial morphology on fluoroscopy time in chimney endovascular aneurysm repair.

    Sugimoto M, Torsello G, Donas KP

    Vascular   Vol. 25 ( 5 ) page: 514 - 519   2017.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/1708538117700765

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  13. Postmarket Clinical Experience with the INCRAFT AAA Stent Graft System for Challenging Access Routes.

    Sugimoto M, Torsello GF, Torsello GB, Austermann M, Stachmann A, Bisdas T

    Annals of vascular surgery   Vol. 40   page: 120 - 127   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.avsg.2016.07.073

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    PubMed

  14. The impact of inflow treatment for claudicants with both aortoiliac and femoropopliteal occlusive disease

    Maekawa T.

    Surgery Today   Vol. 47 ( 3 ) page: 293 - 300   2017.3

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    Publisher:Surgery Today  

    DOI: 10.1007/s00595-016-1399-0

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  15. The Relationship between Temporal Changes in Proximal Neck Angulation and Stent-Graft Migration after Endovascular Abdominal Aortic Aneurysm Repair

    Tokunaga S.

    Annals of Vascular Surgery   Vol. 39   page: 119 - 127   2017.2

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    Publisher:Annals of Vascular Surgery  

    DOI: 10.1016/j.avsg.2016.05.128

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  16. Long-term Comparison of Endovascular and Open Repair of Abdominal Aortic Aneurysms: Retrospective Analysis of Matched Cohorts with Propensity Score

    Sugimoto Masayuki, Koyama Akio, Niimi Kiyoaki, Kodama Akio, Banno Hiroshi, Komori Kimihiro

    ANNALS OF VASCULAR SURGERY   Vol. 43   page: 96 - 103   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.avsg.2017.01.011

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    PubMed

  17. Postoperative outcomes of hybrid repair in the treatment of aortic arch aneurysms

    Narita H.

    Annals of Vascular Surgery   Vol. 34   page: 55 - 61   2016.7

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    Publisher:Annals of Vascular Surgery  

    DOI: 10.1016/j.avsg.2015.11.041

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    Scopus

  18. Tortuosity is the Significant Predictive Factor for Renal Branch Occlusion after Branched Endovascular Aortic Aneurysm Repair

    Sugimoto M.

    European Journal of Vascular and Endovascular Surgery   Vol. 51 ( 3 ) page: 350 - 357   2016.3

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    Publisher:European Journal of Vascular and Endovascular Surgery  

    DOI: 10.1016/j.ejvs.2015.09.013

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  19. Buerger’s disease (thromboangiitis obliterans)

    Sugimoto M.

    Systemic Vasculitides: Current Status and Perspectives     page: 361 - 376   2016.1

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    Publisher:Systemic Vasculitides: Current Status and Perspectives  

    DOI: 10.1007/978-3-319-40136-2_31

    Scopus

  20. Relationship between the distal migration and length of the distal landing zone after endovascular aneurysm repair (EVAR)

    Ihara T.

    Surgery Today   Vol. 46 ( 1 ) page: 56 - 61   2016.1

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    Publisher:Surgery Today  

    DOI: 10.1007/s00595-014-1100-4

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  21. Validation of patient selection for endovascular aneurysm repair or open repair of abdominal aortic aneurysm: Single-center study

    Yamamoto K.

    Circulation Journal   Vol. 79 ( 8 ) page: 1699 - 1705   2015.7

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    Publisher:Circulation Journal  

    DOI: 10.1253/circj.CJ-14-1160

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  22. Risk factors for spinal cord ischemia after endovascular repair of thoracoabdominal aortic aneurysms

    Bisdas T.

    Journal of Vascular Surgery   Vol. 61 ( 6 ) page: 1408 - 1416   2015.6

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    Publisher:Journal of Vascular Surgery  

    DOI: 10.1016/j.jvs.2015.01.044

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  23. The fate of ischemic limbs in patients with Buerger’s disease based on our 30-year experience: does smoking have a definitive impact on the late loss of limbs?

    Sugimoto M.

    Surgery Today   Vol. 45 ( 4 ) page: 466 - 470   2015.4

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    Publisher:Surgery Today  

    DOI: 10.1007/s00595-014-0904-6

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  24. Metformin stimulates ischemia-induced revascularization through an eNOS dependent pathway in the ischemic hindlimb mice model

    Takahashi N.

    Journal of Vascular Surgery   Vol. 61 ( 2 ) page: 489 - 496   2015.2

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    Publisher:Journal of Vascular Surgery  

    DOI: 10.1016/j.jvs.2013.09.061

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  25. Endarteritis obliterans in the pathogenesis of buerger’s disease from the pathological and immunohistochemical points of view

    Kobayashi M.

    Circulation Journal   Vol. 78 ( 12 ) page: 2819 - 2826   2014

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    Publisher:Circulation Journal  

    DOI: 10.1253/circj.CJ-14-0656

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  26. Quality of life and the venous function of the lower limb after harvest of autologous external iliac vein grafts: A clinical follow-up study

    Kaneoka Y.

    Surgery Today   Vol. 43 ( 11 ) page: 1254 - 1260   2013.11

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    Publisher:Surgery Today  

    DOI: 10.1007/s00595-012-0406-3

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  27. Mycotic aneurysm of the tibioperoneal trunk which precipitated acute compartment syndrome: Report of a case

    Sugimoto M.

    Surgery Today   Vol. 42 ( 10 ) page: 1001 - 1004   2012.10

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    Publisher:Surgery Today  

    DOI: 10.1007/s00595-012-0175-z

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  28. Surgical experience of 13 infected infrarenal aortoiliac aneurysms: Preoperative control of septic condition determines early outcome

    Sugimoto Masayuki, Banno Hiroshi, Idetsu Akihito, Matsushita Masahiro, Ikezawa Teruo, Komori Kimihiro

    SURGERY   Vol. 149 ( 5 ) page: 699 - 704   2011.5

  29. Therapeutic approach against intimal hyperplasia of vein grafts through endothelial nitric oxide synthase/nitric oxide (eNOS/NO) and the Rho/Rho-kinase pathway

    Sugimoto Masayuki, Yamanouchi Dai, Komori Kimihiro

    SURGERY TODAY   Vol. 39 ( 6 ) page: 459 - 465   2009.6

  30. Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation

    Nakayama Masanori, Goto Takaaki M., Sugimoto Masayuki, Nishimura Takashi, Shinagawa Takafumi, Ohno Sigeo, Amano Mutsuki, Kaibuchi Kozo

    DEVELOPMENTAL CELL   Vol. 14 ( 2 ) page: 205 - 215   2008.2

  31. Rho-kinase phosphorylates eNOS at threonine 495 in endothelial cells

    Sugimoto Masayuki, Nakayama Masanori, Goto Takaaki M., Amano Mutsuki, Komori Kimihiro, Kaibuchi Kozo

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 361 ( 2 ) page: 462 - 467   2007.9

  32. Identification of Par3asa novel substrate of Rho-kinase

    Nakayama M, Nishimura T, Sugimoto M, Goto T, Ohno S, Amano M, Kaibuchi K

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 100   page: 182P - 182P   2006

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  33. Hydrophilic statin suppresses vein graft intimal hyperplasia via endothelial cell-tropic Rho-kinase inhibition

    Yamanouchi D, Banno H, Nakayama M, Sugimoto M, Fujita H, Kobayashi M, Kuwano H, Komori K

    JOURNAL OF VASCULAR SURGERY   Vol. 42 ( 4 ) page: 757 - 764   2005.10

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KAKENHI (Grants-in-Aid for Scientific Research) 9

  1. 亜鉛をターゲットとした閉塞性動脈硬化症に対する新しい治療戦略

    Grant number:20K09123  2020.4 - 2023.3

    古森 公浩

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    亜鉛は生命体における必須ミネラルで、近年亜鉛欠乏と動脈硬化との関連が報告されている。また我々は重症下肢虚血における下肢バイパス術の臨床的検討において亜鉛欠乏群では、正常群に比べバイパス開存率・救肢率・Amputation free survaival・創傷治癒率は不良であることを世界で初めて報告した。亜鉛欠乏と血管内膜肥厚および下肢虚血作成後の血管新生反応に及ぼす影響についての検討は、これまでになされていない。本研究の目的は、亜鉛欠乏モデルに関して検討し閉塞性動脈硬化症(ASO)に対する新規治療戦略を提唱することにある。

  2. Xa阻害剤をターゲットとした新しい血管病治療の探索研究

    Grant number:18K08728  2018.4 - 2021.3

    坂野 比呂志

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    In vitro マウスの腹水由来マクロファージをTNF-αで刺激し、Edoxabanのみ(30μM、3μM、0.3μM、投与なし)を添加し、RNAを抽出、qPCRを用いて遺伝子発現解析を行った。次に同様のマクロファージを使用し、TNF-αで刺激後、FXaとEdoxabanを添加し、同様に遺伝子発現解析を行った。In vivo ApolipoproteinE-/-マウスにアンギオテンシンⅡを持続皮下注しマウス動脈瘤モデルとして使用した。生食群、Edoxaban 投与群に分類し、動脈瘤形成の予防効果につき検討を行った。生食群、Edoxaban 投与群(0.2mg/kg/day、2mg/kg/day、20mg/kg/day)に分類した。7、14、21、28日目に超音波検査にて大動脈瘤径の計測を行い、28日目に屠殺し大動脈瘤径を計測した。
    結果:In vitro FXaを不添加の場合4種類の濃度の間で有意差は認めなかった。FXa添加の場合TNF-αで3μMと0.3μMの間以外でより濃度が濃い群で有意に遺伝子発現が高かった。IL-1bでは全群間で濃度が濃い群に有意に遺伝子発現が高かった。IL-6では0.3μMと投与なし、3μMと投与なしの間で濃度が濃い群に有意に遺伝子発現が高かった。Cathepsin Kでは3μMと投与なし、3μMと0.3μMで濃度が濃い群に有意に遺伝子発現が高かった。Cathepsin Sでは0.3μMと投与なし、3μMと投与なしの間で濃度が濃い群に有意に遺伝子発現が高かった。その他はグループ間に有意差は認めなかった。In vivo 副作用思われるものとして全濃度で肛門出血を認めた。大動脈瘤径は群間で有意差は認めなかった。生食群に比べ20mg/kg/day Edoxavan群でやや小さくなっている傾向は認めたが、有意ではなかった。(p=0.123)。
    In vitro、及びIn vivoにおいて今回の実験では、Edoxavan投与でマクロファージに対する抗炎症効果は確認できず、また動脈瘤抑制、予防効果も明らかではなかった。
    前回アピキサバン、今回エドキザバンによる動脈瘤形成抑制、予防効果は確認できなかったが、現在いくつかのXa阻害剤がすでに臨床応用されている。今後は同様のモデルを使用して、他のXa阻害剤による動脈瘤形成抑制、予防効果を検討していく。さらにXa阻害剤には多面的な血管保護作用が期待される。特にASOをはじめとした動脈硬化性疾患は、マクロファージを中心とした慢性炎症を基盤として発症する。最近の研究から、複数の凝固因子が血栓形成のみならず、さまざまな細胞に発現するプロテアーゼ活性化受容体(PAR)を介して、炎症反応にも関与することが知られている。なかでも、PARのサブタイプPAR-2が慢性炎症に強く関与する可能性が示唆されている。PAR-2の主要なリガンドの一つであるFXaを直接的に阻害するリバーロキサバンなどのXa阻害剤は、抗凝固作用による血栓塞栓症の抑制のみならず、急性冠症候群患者における心血管イベント抑制にも有用であることが示されている。実際に動脈硬化モデルApo-E欠損マウスでは、FXaの作用受容体であるPAR-1、PAR-2の発現亢進を認め、FXa阻害薬であるリバーロキサバンの投与により、同モデルの動脈硬化の形成やプラークの不安定化が抑制され、大動脈の炎症性メディエーターの発現が減少した。動脈瘤以外の他の血管病に対するXa阻害剤の効果検討として、我々がすでにモデルを確立した静脈グラフト内膜肥厚やステント再狭窄の抑制効果を検討していく。また同様に下肢虚血モデルにおける血管新生能についても検討していく。

  3. Potent Inhibiting Effect of Activated vitamine D3 on Aortic Aneurysm Dilatation

    Grant number:17K10753  2017.4 - 2020.3

    NIIMI Kiyoaki

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    The activity of endogenous MCP-1 was significantly lower in the calsitriol group than in the Saline group. However, there was no significant difference in expression level of IL-1βand MMP-9 causing degeneration of the extracellular matrix between the Saline and calsitriol groups. In that series, we decided to evaluate another anti-inflammatory subject that can suppress atherosclerotic disease. Montelukast is a selective CVS-LT-1receptor antagonist that could surpress atherosclerotic diseases. We evaluated the in vitro properties of montelukast and its in vivo activities in an angiotensinⅡ-infused apolipoprotein E-deficient AAA mouse model. Relative to control,montelukast significantly suppressed gene expression of MMP-2, MMP-9, and IL-1β.In vivo,montelukast significantly decreased aortic expansion and induced infiltration of M2 macrophages.

  4. Functions of Nitric Oxide and Endothelium-derived Hyperpolarizing Factor are impaired in Poor Run-off Autogenous Rabbit Arterial Grafts

    Grant number:17H04290  2017.4 - 2020.3

    KOMORI Kimihiro

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    Background: Vascular endothelium induces smooth muscle cell (SMC) relaxation mainly mediated by endothelium-derived nitric oxide (EDNO) and endothelium-derived hyperpolarizing factor (EDHF). The present study was undertaken to determine whether the functions of EDNO and EDHF might be altered in poor run-off artery graft compared to “non-occluded graft”. Methods: The carotid artery was excised and implanted in its original position as an autogenous graft(“non-occluded graft”), and the most inferior branch of the external carotid artery served as the only outflow for the present conditions (“poor run-off graft”).
    Conclusions: The functions of both EDNO and EDHF are impaired in poor run-off artery grafts.

  5. 3D Imaging Analysis to Elucidate Predictors for Long-term results after Endovascular Aortic Aneurysm Repair

    Grant number:16K10657  2016.4 - 2019.3

    SUGIMOTO Masayuki

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    Authorship:Principal investigator 

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    In this observational clinical study, longitudinal anatomical measurement of abdominal aortic aneurysms after endovascular repair was performed using a dedicated 3D workstation (Aquarius; TeraRecon). Statistical analysis of those anatomical factors, in combination with clinical data, has revealed: 1) specific clinical backgrounds of our series in comparison with other large clinical studies, 2) several predictors for long-term outcomes such as aneurysmal shrinkage. Notably, our study has elucidated new insights about predictors for type II endoleak and resulting aneurysm enlargement.

  6. The protective effects of adiponectin of CaCl2-induced aneurysm formation

    Grant number:25462160  2013.4 - 2016.3

    TOKUNAGA Seisaku

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    Abdominal aortic aneurysm (AAA) is a feature of various vascular disorders including atherosclerosis and hypertension. A peroxisome proliferator-activated receptor-γ(PPARγ) ligand, pioglitazone is a relative new class of oral agent for the treatment of type 2 diabetes and insulin resistance. Pioglitazone has beneficial effects on endothelial function, hypertension and atherosclerosis. Here we investigated the effect of pioglitazone on AAA. The AAA model was induced by CaCl2 in male mice, and mice were treated with pioglitazone as food admixture at a concentration of 0.01%. Treatment of wild-type (WT) mice with pioglitazone attenuated CaCl2-induced aneurysm formation in mice. Pioglitazone also increased plasma adiponectin level in WT mice. However, adiponectin-deficient mice did not affect in CaCl2-induced aneurysm formation. These data provide direct evidence that pioglitazone protects against CaCl2-induced aneurysm formation via an adiponectin-independent mechanism.

  7. New therapeutic approach for targeting endothelium-derived hyper polarizing factor in the intimal hyperplasia of vein and artery grafts.

    Grant number:25293295  2013.4 - 2016.3

    KOMORI Kimihiro

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    The vascular endothelium induces smooth muscle relaxation mainly mediated by nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF). The present study was undertaken to determine whether the functions of NO and EDHF may be altered in rabbit artery grafts.
    At 28 days after the operation.Intimal hyperplasia was observed in "artery graft". When compared with "control artery","artery graft” exhibited greater acetylcholine-induced endothelium-dependent relaxation. Both the acetylcholine-induced increase in endothelial cell [Ca2+]i and the endothelium-dependent SMC hyperpolarization were weaker in "artery graft". Endothelial NO release under basal conditions was enhanced, while acetylcholine-induced endothelium-dependent SMC hyperpolarization was reduced in artery grafts.
    It is suggested that enhanced NO production is responsible for the increased acetylcholine-induced endothelium-dependent relaxation, and for minimizing intimal hyperplasia, in a rabbit artery graft.

  8. The effect of PPARalpha agonist fibrate on the intimal hyperplasia of autologous jugular vein grafts

    Grant number:24591873  2012.4 - 2015.3

    SUGIMOTO MASAYUKI

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    Authorship:Principal investigator 

    Grant amount:\5330000 ( Direct Cost: \4100000 、 Indirect Cost:\1230000 )

    The purpose of this study is to examine the effect of drugs on intimal hyperplasia. We did not receive the effect of PPARα agonist fibrate, however, dipeptidyl peptidase 4 inhibitors, which are widely used in patients with type 2 diabetes mellitus, inhiibit the intimal hyperplasia of autologous jugular vein grafts. The rabbits were randomly divided into vildagliptin (a potent dipeptidyl peptidase 4 inhibitor) group and , control group. Results: Under fasting conditions, vildagliptin increased the plasma GLP-1 concentration, without affecting plasma glucose. Acetylcholine induced endothelium-dependent relaxation only in the vildagliptin group. Intimal hyperplasia was significantly less in the vildagliptin group than in the controls. Conclusions: Vildagliptin increased the plasma GLP-1 concentration. It also enhanced acetylcholine-induced [Ca2+]i- independent endothelial nitric oxide release and reduced vein graft intimal hyperplasia, independently of any glycemic control action.

  9. New strategy using diabetes therapeutic drug for the patients with vascular disease

    Grant number:24659586  2012.4 - 2014.3

    KOMORI KIMIHIRO

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    (Background) We investigated whether metformin modulates the revascularization processes in vivo employing a hindlimb model of ischemia-induced angiogenesis. (Methods)Wild-type (WT) mice or eNOS deficient (eNOS-KO) mice were randomly divided into two groups. Mice were treated with or without metformine and were subjected to unilateral hind limb ischemia.(Results)WT mice (metformin group) showed accelerated limb perfusion following hindlimb ischemic surgery based upon laser Doppler measurements of blood flow and increased capillary density in ischemic muscle compared to non-treated mice. Metformin group significantly enhanced ischemia-induced increase in AMPK and eNOS phosphorylation levels in WT mice. In eNOS-KO mice, metformin significantly increased the phosphorylation of AMPK in ischemic tissue, but did not affect blood flow recovery in ischemic limb. (Conclusions)Metformin could promote revascularization in response to tissue ischemia via an AMPK/eNOS-dependent mechanism.

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