Updated on 2021/11/26

写真a

 
KUBA Hiroshi
 
Organization
Graduate School of Medicine Program in Integrated Medicine Cell Science Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine
Title
Professor
Contact information
メールアドレス

Degree 1

  1. Doctor (Medical) ( 1997.3   Kyoto University ) 

Research Interests 9

  1. multiphoton imaging

  2. calcium

  3. plasticity

  4. synapse

  5. receptor

  6. channel

  7. axon initial segment

  8. neuron

  9. Auditory

Current Research Project and SDGs 2

  1. Neural mechanisms of sound localization

  2. Neural plasticity at axon initial segment

Research History 6

  1. Kyoto University, associate professor

    2010.4 - 2011.9

      More details

    Country:Japan

  2. OHSU, visiting fellow

    2009.9 - 2010.2

      More details

    Country:Japan

  3. Kyoto University, lecturer

    2007.7 - 2010.3

      More details

    Country:Japan

  4. Kyoto University, assistant professor

    2003.4 - 2007.6

      More details

    Country:Japan

  5. 国立病院九州医療センター・脳外科研修医

    1999.2 - 1999.3

      More details

    Country:Japan

  6. 九州大学医学部付属病院・脳外科研修医

    1997.6 - 1999.1

      More details

    Country:Japan

▼display all

Education 2

  1. Kyoto University   Graduate School, Division of Medicine

    1999.4 - 2003.3

      More details

    Country: Japan

  2. Kyushu University   Faculty of Medicine

    1991.4 - 1997.3

      More details

    Country: Japan

Professional Memberships 3

  1. 日本生理学会

  2. 日本神経科学学会

  3. 北米神経科学学会

Committee Memberships 1

  1. 日本生理学会   理事  

    2020.4   

      More details

    Committee type:Academic society

Awards 3

  1. NIKON JOICO AWARD2019特別賞受賞

    2019.12   株式会社NIKON  

    関川博、江川遼、久場博司

  2. 日本生理学会奨励賞

    2008.3   日本生理学会  

    久場博司

     More details

    Country:Japan

  3. 日本神経科学学会奨励賞

    2006.7   日本神経科学学会  

    久場博司

     More details

    Country:Japan

 

Papers 29

  1. Dendritic synapse geometry optimizes binaural computation in a sound localization circuit Reviewed

    Yamada R, Kuba H

    Sci. Adv.   Vol. 7 ( 48 ) page: eabh0024   2021.11

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/sciadv.abh0024

  2. Tonotopic specializations in number, size, and reversal potential of GABAergic inputs fine-tune temporal coding at avian cochlear nucleus. Reviewed

    Al-Yaari M, Onogi C, Yamada R, Adachi R, Kondo D, Kuba H

    J. Neurosci.     2021.9

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1523/JNEUROSCI.0884-21.2021

    PubMed

  3. Structural and functional refinement of the axon initial segment in avian cochlear nucleus during development. Reviewed International coauthorship

    Akter N, Fukaya R, Adachi R, Kawabe H, Kuba H

    J. Neurosci.   Vol. 40   page: 6709-6721   2020.8

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1523/JNEUROSCI.3068-19.2020

    PubMed

  4. Excitatory-inhibitory synaptic coupling in avian nucleus magnocellularis. Reviewed

    Al-Yaari M, Yamada R, Kuba H

    J. Neurosci.   Vol. 40   page: 619-631   2020.1

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1523/JNEUROSCI.1124-19.2019

    PubMed

  5. Tonotopic Differentiation of Coupling between Ca2+ and Kv1.1 Expression in Brainstem Auditory Circuit Reviewed

    Adachi R, Yamada R, Kuba H

    iScience   Vol. 13   page: 199-213   2019.3

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.isci.2019.02.022

    Web of Science

    PubMed

  6. Auditory Input Shapes Tonotopic Differentiation of Kv1.1 Expression in Avian Cochlear Nucleus during Late Development. Reviewed

    Akter N, Adachi R, Kato A, Fukaya R, Kuba H.

    J. Neurosci.   Vol. 38 ( 12 ) page: 2967-2980   2018.3

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1523/JNEUROSCI.2472-17.2018

    PubMed

  7. Tonotopic Variation of the T-Type Ca2+ Current in Avian Auditory Coincidence Detector Neurons. Reviewed

    Fukaya R, Yamada R, Kuba H

    J. Neurosci.   Vol. 38   page: 335-346   2018.1

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1523/JNEUROSCI.2237-17.2017

    PubMed

  8. Structural and Functional Plasticity at the Axon Initial Segment Reviewed

    Yamada R, Kuba H

    Front. Cell Neurosci.   Vol. 10   page: 250   2016.10

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fncel.2016.00250

    PubMed

  9. Activity-dependent regulation of excitable axonal domains Invited Reviewed International coauthorship

    Susuki K, Kuba H

    J. Physiol. Sci.   Vol. 66   page: 66-96   2016.3

     More details

    Authorship:Corresponding author   Language:English  

    DOI: 10.1007/s12576-015-0413-4

    PubMed

  10. Redistribution of Kv1 and Kv7 enhances neuronal excitability during structural axon initial segment plasticity Reviewed

    Kuba H, Yamada R, Ishiguro G, Adachi R

    Nat. Commun.   Vol. 6   page: 8815   2015.11

     More details

    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ncomms9815

    PubMed

  11. Plasticity of the axonal trigger zone Invited Reviewed

    Adachi R, Yamada R, Kuba H

    Neuroscientist   Vol. 21   page: 255-265   2015.6

     More details

    Authorship:Corresponding author   Language:English  

    DOI: 10.1177/1073858414535986

    PubMed

  12. Activity-dependent and activity-independent development of the axon initial segment Reviewed

    Kuba H, Adachi R, Ohmori H

    J. Neurosci.   Vol. 34   page: 3443-3453   2014.2

     More details

    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1523/JNEUROSCI.4357-13.2014

    PubMed

  13. Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members Reviewed

    Suzuki J, Fujii T, Imao T, Ishihara K, Kuba H, Nagata S

    J. Biol. Chem.   Vol. 288   page: 13305-13316   2013.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M113.457937

    PubMed

  14. The cooperation of sustained and phasic inhibitions increases the contrast of ITD-tuning in low-frequency neurons of the chick nucleus laminaris Reviewed International coauthorship

    Yamada R, Okuda H, Kuba H, Nishino E, Ishii TM, Ohmori H

    J. Neurosci.   Vol. 33   page: 3927-3938   2013.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1523/JNEUROSCI.2377-12.2013

    PubMed

  15. Activation of metabotropic glutamate receptors improves the accuracy of coincidence detection by presynaptic mechanisms in the nucleus laminaris of the chick Reviewed

    Okuda H, Yamada R, Kuba H, Ohmori H

    J. Physiol. (Lond.)   Vol. 591   page: 365-378   2013.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1113/jphysiol.2012.244350

    PubMed

  16. Structural tuning and plasticity at the axon initial segment in auditory neurons Invited Reviewed

    Kuba H

    J. Physiol. (Lond.)   Vol. 590   page: 5571-5579   2012.11

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1113/jphysiol.2012.237305

    PubMed

  17. Inhibition of presynaptic Na(+)/K(+)-ATPase reduces readily releasable pool size at the avian end-bulb synapse Reviewed

    Taruno A, Ohmori H, Kuba H

    Neurosci. Res.   Vol. 72   page: 117-128   2012.2

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neures.2011.11.003

    PubMed

  18. Short- and long-term plasticity at the axon initial segment Invited Reviewed

    Grubb MS, Shu Y, Kuba H, Rasband MN, Wimmer VC, Bender KJ

    J. Neurosci.   Vol. 31   page: 16045-16055   2011.11

     More details

    Language:English  

    DOI: 10.1523/JNEUROSCI.4064-11.2011

    PubMed

  19. Plasticity at the axon initial segment Invited Reviewed

    Kuba H

    Commun. Integr. Biol.   Vol. 3   page: 597-598   2010.11

     More details

    Authorship:Lead author   Language:English  

    DOI: 10.4161/cib.3.6.13242

    PubMed

  20. Presynaptic activity regulates Na+ channel distribution at the axon initial segment Reviewed

    Kuba H, Oichi Y, Ohmori H

    Nature   Vol. 465   page: 1075-1078   2010.6

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nature09087

    PubMed

  21. Roles of axonal sodium channels in precise auditory time coding at nucleus magnocellularis of the chick Reviewed

    Kuba H, Ohmori H

    J. Physiol. (Lond.)   Vol. 587   page: 87-100   2009.1

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1113/jphysiol.2008.162651

    PubMed

  22. Sound-intensity dependent compensation for the small interaural time difference cue for sound source localization Reviewed

    Nishino E, Yamada R, Kuba H, Hioki H, Furuta T, Kaneko T, Ohmori H

    J. Neurosci.   Vol. 28   page: 7153-7164   2008.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1523/JNEUROSCI.4398-07.2008

    PubMed

  23. Cellular and molecular mechanisms of avian auditory coincidence detection Invited Reviewed

    Kuba H

    Neurosci. Res.   Vol. 59   page: 370-376   2007.12

     More details

    Authorship:Lead author   Language:English  

    DOI: 10.1016/j.neures.2007.08.003

    PubMed

  24. Axonal site of spike initiation enhances auditory coincidence detection Reviewed

    Kuba H, Ishii TM, Ohmori H

    Nature   Vol. 444   page: 1069-1072   2006.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nature05347

    PubMed

  25. Hyperpolarization-activated cyclic nucleotide-gated cation channels regulate auditory coincidence detection in nucleus laminaris of the chick Reviewed

    Yamada R, Kuba H, Ishii TM, Ohmori H

    J. Neurosci.   Vol. 25   page: 8867-8877   2005.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1523/JNEUROSCI.2541-05.2005

    PubMed

  26. Tonotopic specialization of auditory coincidence detection in nucleus laminaris of the chick Reviewed

    Kuba H, Yamada R, Fukui I, Ohmori H

    J. Neurosci.   Vol. 25   page: 1924-1934   2005.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1523/JNEUROSCI.4428-04.2005

    PubMed

  27. Evaluation of the limiting acuity of coincidence detection in nucleus laminaris of the chicken Reviewed

    Kuba H, Yamada R, Ohmori H

    J. Physiol. (Lond.)   Vol. 552   page: 611-620   2003.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1113/jphysiol.2003.041574

    PubMed

  28. Development of membrane conductance improves coincidence detection in the nucleus laminaris of the chick Reviewed

    Kuba H, Koyano K, Ohmori H

    J. Physiol. (Lond.)   Vol. 540   page: 529-542   2002.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1113/jphysiol.2001.013365

    PubMed

  29. Synaptic depression improves coincidence detection in the nucleus laminaris in brainstem slices of the chick embryo Reviewed

    Kuba H, Koyano K, Ohmori H

    Eur. J. Neurosci.   Vol. 15   page: 984-990   2002.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1046/j.1460-9568.2002.01933

    PubMed

▼display all

Research Project for Joint Research, Competitive Funding, etc. 1

  1. 聴覚神経回路での入力依存的な神経活動制御

    2010.10 - 2016.3

    さきがけ 

      More details

    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 9

  1. 神経回路の成熟と動作に興奮性軸索ドメインが果たす役割の解明

    Grant number:21H02577  2021.4 - 2024.3

    久場 博司

      More details

    Authorship:Principal investigator 

    Grant amount:\17420000 ( Direct Cost: \13400000 、 Indirect Cost:\4020000 )

  2. 軸索コンパートメントにおけるスクラップ&ビルド

    2019.4 - 2021.3

    科学研究費補助金 

      More details

    Authorship:Principal investigator 

  3. 軸索起始部の形成原理と分子基盤の解明

    2015.4 - 2018.3

    科学研究費補助金  基盤研究(B)

      More details

    Authorship:Principal investigator 

  4. 聴覚ニューロンの軸索起始部での新規可塑性

    2010.4 - 2013.3

    科学研究費補助金  若手研究(A)

      More details

    Authorship:Principal investigator 

  5. トリ層状核における両耳間時間差検出機構の解明

    2008.4 - 2010.3

    科学研究費補助金  特定領域研究

      More details

    Authorship:Principal investigator 

  6. 活動電位の発生部位が聴覚情報処理に果たす役割の解明

    2007.4 - 2009.3

    科学研究費補助金  若手研究(A)

      More details

    Authorship:Principal investigator 

  7. トリ層状核における両耳間時間差検出機構の解明

    2006.4 - 2008.3

    科学研究費補助金  特定領域研究

      More details

    Authorship:Principal investigator 

  8. 聴覚同時検出器細胞における樹状突起の機能解明

    2005.4 - 2007.3

    科学研究費補助金  若手研究(B)

      More details

    Authorship:Principal investigator 

  9. トリ層状核における両耳間時間差検出機構の解明

    2005.4 - 2006.3

    科学研究費補助金  特定領域研究

      More details

    Authorship:Principal investigator 

▼display all

 

Teaching Experience (On-campus) 3

  1. 基礎セミナーB

    2019

  2. 生体の機能講義

    2019

  3. 生物学基礎2

    2019