Organization
Graduate School of Medicine Program in Integrated Medicine Cell Science Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine
Title
Professor
Contact information
KUBA Hiroshi
Degree 1
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Doctor (Medical) （ 1997.3 Kyoto University ）
Research Interests 9
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multiphoton imaging
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calcium
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plasticity
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synapse
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receptor
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channel
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axon initial segment
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neuron
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Auditory
Current Research Project and SDGs 2
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Neural mechanisms of sound localization
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Neural plasticity at axon initial segment
Research History 6
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Kyoto University, associate professor
2010.4 - 2011.9
Country：Japan
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OHSU, visiting fellow
2009.9 - 2010.2
Country：Japan
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Kyoto University, lecturer
2007.7 - 2010.3
Country：Japan
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Kyoto University, assistant professor
2003.4 - 2007.6
Country：Japan
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国立病院九州医療センター・脳外科研修医
1999.2 - 1999.3
Country：Japan
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九州大学医学部付属病院・脳外科研修医
1997.6 - 1999.1
Country：Japan
Education 2
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Kyoto University Graduate School, Division of Medicine
1999.4 - 2003.3
Country： Japan
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Kyushu University Faculty of Medicine
1991.4 - 1997.3
Country： Japan
Professional Memberships 3
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日本生理学会
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日本神経科学学会
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北米神経科学学会
Committee Memberships 1
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日本生理学会 理事
2020.4
Committee type：Academic society
Awards 3
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NIKON JOICO AWARD2019特別賞受賞
2019.12 株式会社NIKON
関川博、江川遼、久場博司
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日本生理学会奨励賞
2008.3 日本生理学会
久場博司
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日本神経科学学会奨励賞
2006.7 日本神経科学学会
久場博司
Papers 31
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CDK5/p35-dependent microtubule reorganization contributes to homeostatic shortening of the axon initial segment. Reviewed
Jahan I, Adachi R, Egawa R, Nomura H, Kuba H
J. Neurosci. Vol. 14 ( 3 ) page： 359 - 372 2023.1
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Cellular Strategies for Frequency-Dependent Computation of Interaural Time Difference. Reviewed
Yamada R, Kuba H
Front. Synaptic. Neurosci. Vol. 14 page： 891740 2022.5
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Dendritic synapse geometry optimizes binaural computation in a sound localization circuit Reviewed
Yamada R, Kuba H
Sci. Adv. Vol. 7 ( 48 ) page： eabh0024 2021.11
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Tonotopic specializations in number, size, and reversal potential of GABAergic inputs fine-tune temporal coding at avian cochlear nucleus. Reviewed
Al-Yaari M, Onogi C, Yamada R, Adachi R, Kondo D, Kuba H
J. Neurosci. 2021.9
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Structural and functional refinement of the axon initial segment in avian cochlear nucleus during development. Reviewed International coauthorship
Akter N, Fukaya R, Adachi R, Kawabe H, Kuba H
J. Neurosci. Vol. 40 page： 6709-6721 2020.8
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Excitatory-inhibitory synaptic coupling in avian nucleus magnocellularis. Reviewed
Al-Yaari M, Yamada R, Kuba H
J. Neurosci. Vol. 40 page： 619-631 2020.1
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Tonotopic Differentiation of Coupling between Ca2+ and Kv1.1 Expression in Brainstem Auditory Circuit Reviewed
Adachi R, Yamada R, Kuba H
iScience Vol. 13 page： 199-213 2019.3
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Auditory Input Shapes Tonotopic Differentiation of Kv1.1 Expression in Avian Cochlear Nucleus during Late Development. Reviewed
Akter N, Adachi R, Kato A, Fukaya R, Kuba H.
J. Neurosci. Vol. 38 ( 12 ) page： 2967-2980 2018.3
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Tonotopic Variation of the T-Type Ca2+ Current in Avian Auditory Coincidence Detector Neurons. Reviewed
Fukaya R, Yamada R, Kuba H
J. Neurosci. Vol. 38 page： 335-346 2018.1
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Structural and Functional Plasticity at the Axon Initial Segment Reviewed
Yamada R, Kuba H
Front. Cell Neurosci. Vol. 10 page： 250 2016.10
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Activity-dependent regulation of excitable axonal domains Invited Reviewed International coauthorship
Susuki K, Kuba H
J. Physiol. Sci. Vol. 66 page： 66-96 2016.3
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Redistribution of Kv1 and Kv7 enhances neuronal excitability during structural axon initial segment plasticity Reviewed
Kuba H, Yamada R, Ishiguro G, Adachi R
Nat. Commun. Vol. 6 page： 8815 2015.11
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Plasticity of the axonal trigger zone Invited Reviewed
Adachi R, Yamada R, Kuba H
Neuroscientist Vol. 21 page： 255-265 2015.6
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Activity-dependent and activity-independent development of the axon initial segment Reviewed
Kuba H, Adachi R, Ohmori H
J. Neurosci. Vol. 34 page： 3443-3453 2014.2
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Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members Reviewed
Suzuki J, Fujii T, Imao T, Ishihara K, Kuba H, Nagata S
J. Biol. Chem. Vol. 288 page： 13305-13316 2013.5
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The cooperation of sustained and phasic inhibitions increases the contrast of ITD-tuning in low-frequency neurons of the chick nucleus laminaris Reviewed International coauthorship
Yamada R, Okuda H, Kuba H, Nishino E, Ishii TM, Ohmori H
J. Neurosci. Vol. 33 page： 3927-3938 2013.2
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Activation of metabotropic glutamate receptors improves the accuracy of coincidence detection by presynaptic mechanisms in the nucleus laminaris of the chick Reviewed
Okuda H, Yamada R, Kuba H, Ohmori H
J. Physiol. (Lond.) Vol. 591 page： 365-378 2013.1
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Structural tuning and plasticity at the axon initial segment in auditory neurons Invited Reviewed
Kuba H
J. Physiol. (Lond.) Vol. 590 page： 5571-5579 2012.11
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Inhibition of presynaptic Na(+)/K(+)-ATPase reduces readily releasable pool size at the avian end-bulb synapse Reviewed
Taruno A, Ohmori H, Kuba H
Neurosci. Res. Vol. 72 page： 117-128 2012.2
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Short- and long-term plasticity at the axon initial segment Invited Reviewed
Grubb MS, Shu Y, Kuba H, Rasband MN, Wimmer VC, Bender KJ
J. Neurosci. Vol. 31 page： 16045-16055 2011.11
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Plasticity at the axon initial segment Invited Reviewed
Kuba H
Commun. Integr. Biol. Vol. 3 page： 597-598 2010.11
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Presynaptic activity regulates Na+ channel distribution at the axon initial segment Reviewed
Kuba H, Oichi Y, Ohmori H
Nature Vol. 465 page： 1075-1078 2010.6
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Roles of axonal sodium channels in precise auditory time coding at nucleus magnocellularis of the chick Reviewed
Kuba H, Ohmori H
J. Physiol. (Lond.) Vol. 587 page： 87-100 2009.1
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Sound-intensity dependent compensation for the small interaural time difference cue for sound source localization Reviewed
Nishino E, Yamada R, Kuba H, Hioki H, Furuta T, Kaneko T, Ohmori H
J. Neurosci. Vol. 28 page： 7153-7164 2008.7
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Cellular and molecular mechanisms of avian auditory coincidence detection Invited Reviewed
Kuba H
Neurosci. Res. Vol. 59 page： 370-376 2007.12
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Axonal site of spike initiation enhances auditory coincidence detection Reviewed
Kuba H, Ishii TM, Ohmori H
Nature Vol. 444 page： 1069-1072 2006.11
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Hyperpolarization-activated cyclic nucleotide-gated cation channels regulate auditory coincidence detection in nucleus laminaris of the chick Reviewed
Yamada R, Kuba H, Ishii TM, Ohmori H
J. Neurosci. Vol. 25 page： 8867-8877 2005.9
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Tonotopic specialization of auditory coincidence detection in nucleus laminaris of the chick Reviewed
Kuba H, Yamada R, Fukui I, Ohmori H
J. Neurosci. Vol. 25 page： 1924-1934 2005.2
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Evaluation of the limiting acuity of coincidence detection in nucleus laminaris of the chicken Reviewed
Kuba H, Yamada R, Ohmori H
J. Physiol. (Lond.) Vol. 552 page： 611-620 2003.10
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Development of membrane conductance improves coincidence detection in the nucleus laminaris of the chick Reviewed
Kuba H, Koyano K, Ohmori H
J. Physiol. (Lond.) Vol. 540 page： 529-542 2002.4
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Synaptic depression improves coincidence detection in the nucleus laminaris in brainstem slices of the chick embryo Reviewed
Kuba H, Koyano K, Ohmori H
Eur. J. Neurosci. Vol. 15 page： 984-990 2002.3
Research Project for Joint Research, Competitive Funding, etc. 1
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聴覚神経回路での入力依存的な神経活動制御
2010.10 - 2016.3
さきがけ
Grant type：Competitive
KAKENHI (Grants-in-Aid for Scientific Research) 11
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Grant number：24H00584 2024.4 - 2029.3
科学研究費助成事業 基盤研究(A)
久場 博司
Authorship：Principal investigator
Grant amount：\48100000 （ Direct Cost: \37000000 、 Indirect Cost：\11100000 ）
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Grant number：22K19358 2022.6 - 2024.3
科学研究費助成事業 挑戦的研究(萌芽)
久場 博司
Authorship：Principal investigator
Grant amount：\6500000 （ Direct Cost: \5000000 、 Indirect Cost：\1500000 ）
神経細胞における活動生成の場である軸索起始部（AIS）は、分布が細胞毎に異なり、かつ可塑的に変化することが明らかとなり、その神経活動制御における重要性が注目されている。しかしながら、生体脳でのAIS分布のダイナミクス、さらにはその脳の機能や病態に及ぼす効果への理解は進んでいない。これは生体脳でAISの観察や操作を行う技術がないことが主な理由である。本研究では、ゲノム編集による内在性蛋白質の蛍光標識と遺伝子ノックアウト技術を駆使することで、生体脳においてAIS分布を連続的に観察する技術と人為的に操作する技術の確立を目指す。
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神経回路の成熟と動作に興奮性軸索ドメインが果たす役割の解明
Grant number：21H02577 2021.4 - 2024.3
久場 博司
Authorship：Principal investigator
Grant amount：\17420000 （ Direct Cost: \13400000 、 Indirect Cost：\4020000 ）
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軸索コンパートメントにおけるスクラップ&ビルド
2019.4 - 2021.3
科学研究費補助金
Authorship：Principal investigator
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軸索起始部の形成原理と分子基盤の解明
2015.4 - 2018.3
科学研究費補助金 基盤研究(B)
Authorship：Principal investigator
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聴覚ニューロンの軸索起始部での新規可塑性
2010.4 - 2013.3
科学研究費補助金 若手研究(A)
Authorship：Principal investigator
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トリ層状核における両耳間時間差検出機構の解明
2008.4 - 2010.3
科学研究費補助金 特定領域研究
Authorship：Principal investigator
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活動電位の発生部位が聴覚情報処理に果たす役割の解明
2007.4 - 2009.3
科学研究費補助金 若手研究(A)
Authorship：Principal investigator
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トリ層状核における両耳間時間差検出機構の解明
2006.4 - 2008.3
科学研究費補助金 特定領域研究
Authorship：Principal investigator
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聴覚同時検出器細胞における樹状突起の機能解明
2005.4 - 2007.3
科学研究費補助金 若手研究(B)
Authorship：Principal investigator
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トリ層状核における両耳間時間差検出機構の解明
2005.4 - 2006.3
科学研究費補助金 特定領域研究
Authorship：Principal investigator
Teaching Experience (On-campus) 3
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基礎セミナーB
2019
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生体の機能講義
2019
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生物学基礎2
2019