日本学術振興会特別研究員(PD)

1998.4 - 1998.9

The nuclear events guiding successful nerve regeneration

Kiryu-Seo Sumiko, Kiyama Hiroshi

FRONTIERS IN MOLECULAR NEUROSCIENCE   Vol. 4   page： 53   2011

Demyelination increases axonal stationary mitochondrial size and the speed of axonal mitochondrial transport.

Kiryu-Seo S, Ohno N, Kidd GJ, Komuro H, Trapp BD

The Journal of neuroscience : the official journal of the Society for Neuroscience   Vol. 30 ( 19 ) page： 6658-66   2010.5

Unique anti-apoptotic activity of EAAC1 in injured motor neurons. Reviewed

Kiryu-Seo S, Gamo K, Tachibana T, Tanaka, K and Kiyama H.

EMBO J   Vol. 25   page： 3411-3421   2006

Damage-induced neuronal endopeptidase (DINE) is a unique metallopeptidase expressed in response to neuronal damage and activates superoxide scavengers

Kiryu-Seo S, Sasaki M, Yokohama H, Nakagomi S, Hirayama T, Aoki S, Wada K, Kiyama H

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   Vol. 97 ( 8 ) page： 4345-4350   2000.4

Repeated cold stress, an animal model for fibromyalgia, elicits proprioceptor-induced chronic pain with microglial activation in mice Reviewed

Koji Wakatsuki, Sumiko Kiryu-Seo, Masaya Yasui, Hiroki Yokota, Haruku Kida, Hiroyuki Konishi, Hiroshi Kiyama

Journal of Neuroinflammation   Vol. 21 ( 1 ) page： 25   2024.1

Brain injury triggers cell-type-specific and time-dependent endoplasmic reticulum stress responses

Fan Qiyan, Takarada-Iemata Mika, Okitani Nahoko, Tamatani Takashi, Ishii Hiroshi, Hattori Tsuyoshi, Kiryu-Seo Sumiko, Kiyama Hiroshi, Hori Osamu

GLIA   Vol. 71 ( 3 ) page： 667 - 681   2023.5

Expression of ATP-binding cassette transporter A1 is induced by nerve injury and its deficiency affects neurite tip morphology and elongation in cultured neurons Reviewed

J Chem Neuroanat   Vol. 125   2022.9

Axonal injury alters the extracellular glial environment of the axon initial segment and allows substantial mitochondrial influx into axon initial segment Reviewed

Hiromi Tamada, Sumiko Kiryu-Seo, Sohgo Sawada, Hiroshi Kiyama

J Comp Neurol   Vol. 529 ( 16 ) page： 3621 - 3632   2021.11

Zonisamide ameliorates neuropathic pain partly by suppressing microglial activation in the spinal cord in a mouse model

Koshimizu Hiroyuki, Ohkawara Bisei, Nakashima Hiroaki, Ota Kyotaro, Kanbara Shunsuke, Inoue Taro, Tomita Hiroyuki, Sayo Akira, Kiryu-Seo Sumiko, Konishi Hiroyuki, Ito Mikako, Masuda Akio, Ishiguro Naoki, Imagama Shiro, Kiyama Hiroshi, Ohno Kinji

LIFE SCIENCES   Vol. 263   page： 118577   2020.12

TC10, a Rho family GTPase, is required for efficient axon regeneration in a neuron-autonomous manner Reviewed

Koinuma Shingo, Negishi Ryota, Nomura Riko, Sato Kazuki, Kojima Takuya, Segi-Nishida Eri, Goitsuka Ryo, Iwakura Yoichiro, Wada Naoyuki, Koriyama Yoshiki, Kiryu-Seo Sumiko, Kiyama Hiroshi, Nakamura Takeshi

JOURNAL OF NEUROCHEMISTRY     2020.11

New Insights of a Neuronal Peptidase DINE/ECEL1: Nerve Development, Nerve Regeneration and Neurogenic Pathogenesis.

Kiryu-Seo S, Nagata K, Saido TC, Kiyama H

Neurochemical research     2018.10

Mitochondrial behavior during axon regeneration/degeneration in vivo.

Kiryu-Seo S, Kiyama H

Neuroscience research     2018.9

Distinct functional consequences of ECEL1/DINE missense mutations in the pathogenesis of congenital contracture disorders

Nagata Kenichi, Takahashi Mika, Kiryu-Seo Sumiko, Kiyama Hiroshi, Saido Takaomi C.

ACTA NEUROPATHOLOGICA COMMUNICATIONS   Vol. 5 ( 1 ) page： 83   2017.11

Three-dimensional analysis of somatic mitochondrial dynamics in fission-deficient injured motor neurons using FIB/SEM

Tamada Hiromi, Kiryu-Seo Sumiko, Hosokawa Hiroki, Ohta Keisuke, Ishihara Naotada, Nomura Masatoshi, Mihara Katsuyoshi, Nakamura Kei-ichiro, Kiyama Hiroshi

JOURNAL OF COMPARATIVE NEUROLOGY   Vol. 525 ( 11 ) page： 2535-2548   2017.8

The mitochondrial dynamics after neuronal injury

Kiryu-Seo S., Kiyama H.

JOURNAL OF NEUROCHEMISTRY   Vol. 134   page： 92-92   2015.8

Proteolipid protein cannot replace P0 protein as the major structural protein of peripheral nervous system myelin.

Yin X, Kiryu-Seo S, Kidd GJ, Feltri ML, Wrabetz L, Trapp BD

Glia   Vol. 63 ( 1 ) page： 66-77   2015.1

MICRORNA-124 IS DOWN REGULATED IN NERVE-INJURED MOTOR NEURONS AND IT POTENTIALLY TARGETS MRNAS FOR KLF6 AND STAT3

Nagata K., Hama I., Kiryu-Seo S., Kiyama H.

NEUROSCIENCE   Vol. 256   page： 426-432   2014.1

Expression analysis of the regenerating gene (Reg) family members Reg-III beta and Reg-III gamma in the mouse during development

Matsumoto Sakiko, Konishi Hiroyuki, Maeda Rie, Kiryu-Seo Sumiko, Kiyama Hiroshi

JOURNAL OF COMPARATIVE NEUROLOGY   Vol. 520 ( 3 ) page： 479-494   2012.2

Cleavage of Neuregulin-1 by BACE1 or ADAM10 Protein Produces Differential Effects on Myelination

Luo Xiaoyang, Prior Marguerite, He Wanxia, Hu Xiangyou, Tang Xiaoying, Shen Weizhen, Yadav Satya, Kiryu-Seo Sumiko, Miller Robert, Trapp Bruce D., Yan Riqiang

JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 286 ( 27 ) page： 23967-23974   2011.7

Myelination and axonal electrical activity modulate the distribution and motility of mitochondria at CNS nodes of Ranvier.

Ohno N, Kidd GJ, Mahad D, Kiryu-Seo S, Avishai A, Komuro H, Trapp BD

The Journal of neuroscience : the official journal of the Society for Neuroscience   Vol. 31 ( 20 ) page： 7249-58   2011.5

Altered expression of mRNA for the low-density lipoprotein receptor (LDLR) in injured motor neurons of rodent

Hama Isuzu, Kiryu-Seo Sumiko, Konishi Hiroyuki, Kim Dong-Ho, Saeki Shigeru, Kiyama Hiroshi

NEUROSCIENCE RESEARCH   Vol. 71   page： E339 - E340   2011

Damage-Induced Neuronal Endopeptidase Is Critical for Presynaptic Formation of Neuromuscular Junctions

Nagata Kenichi, Kiryu-Seo Sumiko, Maeda Mitsuyo, Yoshida Kayo, Morita Takashi, Kiyama Hiroshi

JOURNAL OF NEUROSCIENCE   Vol. 30 ( 20 ) page： 6954-6962   2010.5

Molecular characterization and expression of the low-density lipoprotein receptor-related protein-10, a new member of the LDLR gene family

Jeong Young-Hee, Ishikawa Kayoko, Someya Yoshimi, Hosoda Akemi, Yoshimi Tomohiko, Yokoyama Chikako, Kiryu-Seo Sumiko, Kang Man-Jong, Tchibana Taro, Kiyama Hiroshi, Fukumura Tomoe, Kim Dong-Ho, Saeki Shigeru

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 391 ( 1 ) page： 1110-1115   2010.1

PROLONGED STRESS AFFECTS THE HYPOTHALAMIC DOPAMINE SYSTEM AND CAUSES DEGENERATION OF THE PITUITARY CELLS

Ogawa T., Shishioh-Ikejima N., Konishi H., Makino T., Kiryu-Seo S., Tanaka M., Watanabe Y., Kiyama H.

JOURNAL OF NEUROCHEMISTRY   Vol. 110   page： 196-196   2009.9

PROLONGED STRESS AFFECTS THE HYPOTHALAMIC DOPAMINE SYSTEM AND CAUSES DEGENERATION OF THE PITUITARY CELLS

Ogawa T, Shishioh-Ikejima N, Konishi H, Makino T, Kiryu-Seo S, Tanaka M, Watanabe Y, Kiyama H

JOURNAL OF NEUROCHEMISTRY   Vol. 110   page： 196-196   2009.9

Chronic stress elicits prolonged activation of alpha-MSH secretion and subsequent degeneration of melanotroph

Ogawa Tokiko, Shishioh-Ikejima Nobue, Konishi Hiroyuki, Makino Tetsuya, Sei Hiroyoshi, Kiryu-Seo Sumiko, Tanaka Masaaki, Watanabe Yasuyoshi, Kiyama Hiroshi

JOURNAL OF NEUROCHEMISTRY   Vol. 109 ( 5 ) page： 1389-1399   2009.6

G-Protein-Coupled Receptor Screen Reveals a Role for Chemokine Receptor CCR5 in Suppressing Microglial Neurotoxicity

Gamo Kazushige, Kiryu-Seo Sumiko, Konishi Hiroyuki, Aoki Shunsuke, Matsushima Kouji, Wada Keiji, Kiyama Hiroshi

JOURNAL OF NEUROSCIENCE   Vol. 28 ( 46 ) page： 11980-11988   2008.11

Neuronal injury-inducible gene is synergistically regulated by ATF3, c-Jun, and STAT3 through the interaction with Sp1 in damaged neurons

Kiryu-Seo Sumiko, Kato Ryuichi, Ogawa Tokiko, Nakagomi Saya, Nagata Kenichi, Kiyama Hiroshi

JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 283 ( 11 ) page： 6988-6996   2008.3

Suture of transected nerve suppresses expression of BH3-only protein noxa in nerve-transected motor neurons of C57BL/6J mouse

Gamo Kazushige, Kiryu-Seo Sumiko, Yoshikawa Hideki, Kiyama Hiroshi

JOURNAL OF NEUROTRAUMA   Vol. 24 ( 5 ) page： 876-884   2007.5

Altered expression of Smad family members in injured motor neurons of rat

Okuyama Noriko, Kiryu-Seo Sumiko, Kiyama Hiroshi

BRAIN RESEARCH   Vol. 1132 ( 1 ) page： 36-41   2007.2

Unique anti-apoptotic activity of EAAC1 in injured motor neurons

Kiryu-Seo Sumiko, Gamo Kazushige, Tachibana Taro, Tanaka Kohichi, Kiyama Hiroshi

EMBO JOURNAL   Vol. 25 ( 14 ) page： 3411-3421   2006.7

Identification and functional analysis of damage-induced neuronal endopeptidase (DINE), a nerve injury associated molecule

Kiryu-Seo Sumiko

ANATOMICAL SCIENCE INTERNATIONAL   Vol. 81 ( 1 ) page： 1-6   2006.3

Localization and ontogeny of damage-induced neuronal endopeptidase mRNA-expressing neurons in the rat nervous system

Nagata K., Kiryu-Seo S., Kiyama H.

NEUROSCIENCE   Vol. 141 ( 1 ) page： 299-310   2006

Transcriptional regulation of DINE in response to nerve injury

Kiryu-Seo Sumiko, Kato Ryuichi, Kiyama Hiroshi

NEUROSCIENCE RESEARCH   Vol. 55   page： S218 - S218   2006

Induced expressions of Rab24 GTPase and LC3 in nerve-injured motor neurons

Egami Y, Kiryu-Seo S, Yoshimori T, Kiyama H

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 337 ( 4 ) page： 1206-1213   2005.12

Altered expression of neprilysin family members in the pituitary gland of sleep-disturbed rats, an animal model of severe fatigue

Ogawa T, Kiryu-Seo S, Tanaka M, Konishi H, Iwata N, Saido T, Watanabe Y, Kiyama H

JOURNAL OF NEUROCHEMISTRY   Vol. 95 ( 4 ) page： 1156-1166   2005.11

Altered expression of Neprilysin family members in pituitary gland of chronically sleep disturbed rat

Ogawa T, Kiryu-Seo S, Tanaka M, Iwata N, Saido TC, Watanabe Y, Kiyama H

JOURNAL OF NEUROCHEMISTRY   Vol. 94   page： 242-242   2005.8

The p53-independent nuclear translocation of cyclin G1 in degenerating neurons by ischemic and traumatic insults

Maeda M, Ampo KI, Kiryu-Seo S, Konishi H, Ohba N, Kadono C, Kiyama H

EXPERIMENTAL NEUROLOGY   Vol. 193 ( 2 ) page： 350-360   2005.6

Noxa is a critical mediator of p53-dependent motor neuron death after nerve injury in adult mouse

Kiryu-Seo S, Hirayama T, Kato R, Kiyama H

JOURNAL OF NEUROSCIENCE   Vol. 25 ( 6 ) page： 1442-1447   2005.2

Expression of damage-induced neuronal endopeptidase (DINE) mRNA in peri-infarct cortical and thalamic neurons following middle cerebral artery occlusion

Ohba N, Kiryu-Seo S, Maeda M, Muraoka M, Ishii M, Kiyama H

JOURNAL OF NEUROCHEMISTRY   Vol. 91 ( 4 ) page： 956-964   2004.11

Dine (damage induced neuronal endopeptidase)

Kiryu-Seo S, Kiyama H

PROTEIN AND PEPTIDE LETTERS   Vol. 11 ( 5 ) page： 451-460   2004.10

Transgenic mouse overexpressing the Akt reduced the volume of infarct area after middle cerebral artery occlusion

Ohba N, Kiryu-Seo S, Maeda M, Muraoka M, Ishii M, Kiyama H

NEUROSCIENCE LETTERS   Vol. 359 ( 3 ) page： 159-162   2004.4

Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death

Imaizumi K, Benito A, Kiryu-Seo S, Gonzalez V, Inohara N, Leiberman AP, Kiyama H, Nunez G

JOURNAL OF NEUROSCIENCE   Vol. 24 ( 15 ) page： 3721-3725   2004.4

Vesicular acetylcholine transporter can be a morphological marker for the reinnervation to muscle of regenerating motor axons

Maeda M, Ohba N, Nakagomi S, Suzuki Y, Kiryu-Seo S, Namikawa K, Kondoh W, Tanaka A, Kiyama H

NEUROSCIENCE RESEARCH   Vol. 48 ( 3 ) page： 305-314   2004.3

Dine (damage induced neuronal endopeptidase) Invited Reviewed

Kiryu-Seo S,. Kiyama H.

Protein Pept. Lett.   Vol. 11   page： 451-460   2004

Cavernous nerve injury elicits GAP-43 mRNA expression but not regeneration of injured pelvic ganglion neurons

Kato R, Kiryu-Seo S, Sato Y, Hisasue S, Tsukamoto T, Kiyama H

BRAIN RESEARCH   Vol. 986 ( 1-2 ) page： 166-173   2003.10

Collapsin response mediator protein-2 accelerates axon regeneration of nerve-injured motor neurons of rat

Suzuki Y, Nakagomi S, Namikawa K, Kiryu-Seo S, Inagaki N, Kaibuchi K, Aizawa H, Kikuchi K, Kiyama H

JOURNAL OF NEUROCHEMISTRY   Vol. 86 ( 4 ) page： 1042-1050   2003.8

Expression of the activating transcription factor 3 prevents c-Jun N-terminal kinase-induced neuronal death by promoting heat shock protein 27 expression and Akt activation.

Nakagomi S, Suzuki Y, Namikawa K, Kiryu-Seo S, Kiyama H

The Journal of neuroscience : the official journal of the Society for Neuroscience   Vol. 23 ( 12 ) page： 5187-96   2003.6

Expression of the activating transcription factor 3 prevents c-Jun N-terminal kinase-induced neuronal death by promoting heat shock protein 27 expression and Akt activation

Nakagomi S, Suzuki Y, Namikawa K, Kiryu-Seo S, Kiyama H

JOURNAL OF NEUROSCIENCE   Vol. 23 ( 12 ) page： 5187-5196   2003.6

Identification of an axotomy-induced glycosylated protein, AIGP1, possibly involved in cell death triggered by endoplasmic reticulum-Golgi stress.

Aoki S, Su Q, Li H, Nishikawa K, Ayukawa K, Hara Y, Namikawa K, Kiryu-Seo S, Kiyama H, Wada K

The Journal of neuroscience : the official journal of the Society for Neuroscience   Vol. 22 ( 24 ) page： 10751-60   2002.12

Damage-induced neuronal endopeptidase (DINE/ECEL) expression is regulated by leukemia inhibitory factor and deprivation of nerve growth factor in rat sensory ganglia after nerve injury

Kato R, Kiryu-Seo S, Kiyama H

JOURNAL OF NEUROSCIENCE   Vol. 22 ( 21 ) page： 9410-9418   2002.11

Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases

Shirotani K, Tsubuki S, Iwata N, Takaki Y, Harigaya W, Maruyama K, Kiryu-Seo S, Kiyama H, Iwata H, Tomita T, Iwatsubo T, Saido TC

JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 276 ( 24 ) page： 21895-21901   2001.6

A disintegrin and metalloprotease with thrombospondin type1 motifs (ADAMTS-1) and IL-1 receptor type 1 mRNAs are simultaneously induced in nerve injured motor neurons

Sasaki M, Seo-Kiryu S, Kato R, Kita S, Kiyama H

MOLECULAR BRAIN RESEARCH   Vol. 89 ( 1-2 ) page： 158-163   2001.4

Endothelin-converting enzymes and endothelin receptor B messenger RNAs are expressed in different neural cell species and these messenger rnas are coordinately induced in neurons and astrocytes respectively following nerve injury

Nakagomi S, Kiryu-Seo S, Kiyama H

NEUROSCIENCE   Vol. 101 ( 2 ) page： 441-449   2000

Discordant expression of c-Ret and glial cell line-derived neurotrophic factor receptor alpha-1 mRNAs in response to motor nerve injury in neonate rats

Tsujino H, Mansur K, Kiryu-Seo S, Namikawa K, Kitahara T, Tanabe K, Ochi T, Kiyama H

MOLECULAR BRAIN RESEARCH   Vol. 70 ( 2 ) page： 298-303   1999.7

Dimethylarginine dimethylaminohydrolase (DDAH) as a nerve-injury-associated molecule: mRNA localization in the rat brain and its coincident up-regulation with neuronal NO synthase (nNOS) in axotomized motoneurons

Nakagomi S, Kiryu-Seo S, Kimoto M, Emson PC, Kiyama H

EUROPEAN JOURNAL OF NEUROSCIENCE   Vol. 11 ( 6 ) page： 2160-2166   1999.6

Expressed-sequence-tag approach to identify differentially expressed genes following peripheral nerve axotomy

Tanabe K, Nakagomi S, Kiryu-Seo S, Namikawa K, Imai Y, Ochi T, Tohyama M, Kiyama H

MOLECULAR BRAIN RESEARCH   Vol. 64 ( 1 ) page： 34-40   1999.1

A sequence-specific splicing activator, Tra2 beta, is up-regulated in response to nerve injury

Kiryu-Seo S, Matsuo N, Wanaka A, Ogawa S, Tohyama M, Kiyama H

MOLECULAR BRAIN RESEARCH   Vol. 62 ( 2 ) page： 220-223   1998.11

Up-regulation of thioredoxin expression in motor neurons after nerve injury

Mansur K, Iwahashi Y, Kiryu-Seo S, Su Q, Namikawa K, Yodoi J, Kiyama H

MOLECULAR BRAIN RESEARCH   Vol. 62 ( 1 ) page： 86-91   1998.11

Enhancement of extracellular glutamate scavenge system in injured motoneurons

Toki H, Namikawa K, Su QN, Kiryu-Seo S, Sato K, Kiyama H

JOURNAL OF NEUROCHEMISTRY   Vol. 71 ( 3 ) page： 913-919   1998.9

Enhanced expression of 14-3-3 family members in injured motoneurons

Namikawa K, Su QN, Kiryu-Seo S, Kiyama H

MOLECULAR BRAIN RESEARCH   Vol. 55 ( 2 ) page： 315-320   1998.4

Alternative expression of Shc family members in nerve-injured motoneurons

Tanabe K, Kiryu-Seo S, Nakamura T, Mori N, Tsujino H, Ochi T, Kiyama H

MOLECULAR BRAIN RESEARCH   Vol. 53 ( 1-2 ) page： 291-296   1998.1

Selective upregulation of cytokine receptor subchain and their intracellular signalling molecules after peripheral nerve injury

Yao GL, Kato H, Khalil M, Kiryu S, Kiyama H

EUROPEAN JOURNAL OF NEUROSCIENCE   Vol. 9 ( 5 ) page： 1047-1054   1997.5

p53-independent cyclin G expression in a group of mature neurons and its enhanced expression during nerve regeneration

Morita N, Kiryu S, Kiyama H

JOURNAL OF NEUROSCIENCE   Vol. 16 ( 19 ) page： 5961-5966   1996.10

Nerve injury enhances rat neuronal glutamate transporter expression: Identification by differential display PCR

Kiryu S, Yao GL, Morita N, Kato H, Kiyama H

JOURNAL OF NEUROSCIENCE   Vol. 15 ( 12 ) page： 7872-7878   1995.12

UP-REGULATION OF FERRITIN HEAVY-CHAIN MESSENGER-RNA EXPRESSION IN THE RAT SKELETAL-MUSCLE AFTER DENERVATION - DETECTED BY MEANS OF DIFFERENTIAL DISPLAY

KITAHARA T, KIRYU S, TAKEDA N, KUBO T, KIYAMA H

NEUROSCIENCE RESEARCH   Vol. 23 ( 4 ) page： 353-360   1995.11

REGULATION OF MESSENGER-RNA EXPRESSION INVOLVED IN RAS AND PKA SIGNAL PATHWAYS DURING RAT HYPOGLOSSAL NERVE REGENERATION

KIRYU S, MORITA N, OHNO K, MAENO H, KIYAMA H

MOLECULAR BRAIN RESEARCH   Vol. 29 ( 1 ) page： 147-156   1995.3

UP-REGULATION OF ERK (MAP KINASE) AND MEM (MAP KINASE KINASE) TRANSCRIPTION AFTER RAT FACIAL-NERVE TRANSECTION

KITAHARA T, KIRYU S, OHNO K, MORITA N, KUBO T, KIYAMA H

NEUROSCIENCE RESEARCH   Vol. 20 ( 3 ) page： 275-280   1994.9

組織損傷に応答してスイッチオンされる神経依存性創傷治癒

桐生寿美子

第64回日本神経病理学会総会学術研究会/第66回日本神経化学会大会 合同大会  2023.7.7 

軸索初節の分解と神経再生・変性

桐生寿美子

第128回日本解剖学会総会・ 全国学術集会   2023.3.20 

障害を受けた運動ニューロンが軸索変性を免れる新たな仕組み

桐生寿美子

第１２回名古屋大学医学系研究科・生理学研究所合同シンポジウム  2022.9.10 

軸索初節の可塑性と神経変性・神経炎症

桐生寿美子、木山博資

Neuro2022  2022.7.2 

神経損傷に応答した軸索起始部のダイナミクス

桐生寿美子、木山博資

第64回神経化学会  2021.10.1 

Injured motor neurons lose polarity in a proteasome–dependent manner to increase the mitochondrial transport into regenerative axons

Sumiko Kiryu-Seo, Reika Matsushita, Yoshitaka Tashiro, Ryosuke Takahashi, Takeshi Yoshimura, Yohei Iguchi, Masahisa Katsuno, Hiroshi Kiyama

2021.3.30 

損傷運動ニューロンの軸索再生・変性に関わるプロテアソーム依存性ストレス応答

桐生寿美子、松下鈴佳、田代善崇、高橋良輔、吉村武、井口洋平、勝野雅央、木山博資

第10回名古屋大学医学系研究科・ 生理学研究所合同シンポジウム  2020.9.19 

プロテアソームによるAISの可塑性制御は損傷運動ニューロン軸索のミトコンドリア輸送に関与する

桐生寿美子、松下鈴佳、田代善崇、高橋良輔、吉村武、井口洋平、勝野雅央、木山博資

第63回日本神経化学会大会  2020.9 

損傷運動ニューロンにおいてプロテアソームが関わる新たな神経再生メカニズム

桐生寿美子、松下鈴佳、田代善崇、高橋良輔、吉村武、木山博資

第125回日本解剖学会総会・全国学術集会  2020.3 

神経損傷に応答するプロテアーゼDINEの新たな可能性

桐生寿美子

第92回日本生化学大会  2019.9.19 

Mitochondria in the regenerating and degenerating neurons after nerve injury Invited

APICA  2018.10.29 

The mitochondrial dynamics after motor neuronal injury International conference

Sumiko Kiryu-Seo

International Society for Neurochemistry 2015 

DINE functions as a protease required for the motor nerve terminal arborization and neuromuscular junction formation

Nerve injury-induced mitochondrial fission is an essential adaptive response to maintain neuronal survival and promote axonal regeneration International conference

Sumiko Kiryu-Seo, Hiromi Tamada, Yukina Kato, Naotada Ishihara, Masatoshi Nomura, Katsuyoshi Mihara, Hiroshi Kiyama

Neuroscience2014 

Enzymatic activity of Damage-induced neuronal endopeptidase/Endothelin-converting enzyme-like 1 (DINE/ECEL1) is crucial for neuromuscular junction formation during development. International conference

Sakiko Matsumoto, Sumiko Kiryu-Seo, Hiroshi Kiyama

Neuroscience2014 

DINEのプロテアーゼ活性は脊髄運動ニューロン軸索終末分枝及び神経筋接合部形成に必須である

松本早紀子、桐生寿美子、木山博資

第57回日本神経化学会大会 

Aberrant axonal arborization of motor nerves in Damage-Induced Neuronal Endopeptidase deficient limb International conference

Nagata K, Kiryu-Seo S, Kiyama H, Saido TC.

Cold spring harbor meeting 

The protease activity of DINE/ECEL1 is required for the motor nerve terminal arborization and the neuromuscular junction formation International conference

Matsumoto S, Kiryu-Seo S, Kiyama H.

6th special conference of the international society for neurochemistry  

神経損傷に応答するミトコンドリア

桐生寿美子, 木山博資

第５７回日本神経化学会 

軸索に存在するDINEはシュワン細胞と相互作用することにより適切な軸索ブランチングおよび神経筋接合部形成を促す。

桐生寿美子, 松本早紀子, 木山博資

日本神経科学会 

DINE欠損運動神経の骨格筋支配の発生学的異常

永田健一, 桐生寿美子, 斉藤貴志, 木山博資

日本神経科学会 

損傷神経細胞の再生能力に関わる分子メカニズム

桐生寿美子, 木山博資

日本解剖学会 

脱髄による軸索内ミトコンドリアのサイズと輸送速度の変化

桐生寿美子, 大野伸彦, Grahame J. Kidd, 小室仁, Bruce D. Trapp

Neuro2010 

The protease activity of DINE/ECEL1 is required for the motor nerve terminal arborization and the neuromuscular junction formation

Matsumoto S, Kiryu-Seo S, Kiyama H

6th special conference of the international society for neurochemistry  2014.9 

Injured motor neurons lose polarity in a proteasome–dependent manner to increase the mitochondrial transport into regenerative axons

Sumiko Kiryu-Seo, Reika Matsushita, Yoshitaka Tashiro, Ryosuke Takahashi, Takeshi Yoshimura, Yohei Iguchi, Masahisa Katsuno, Hiroshi Kiyama

2021.3.21 

軸索初節のダイナミクスと神経再生・変性

桐生寿美子

第46回日本神経科学大会  2023.8.2 

軸索-シュワン細胞間の相互作用を制御するDINE複合体蛋白質の同定

2013.4 - 2016.3

武田科学振興財団医学系研究助成 

神経損傷•修復過程におけるDINEの機能

2007.4 - 2009.3

奨励研究助成 

DINEによる損傷神経細胞修復の分子メカニズム

2007.4 - 2008.3

研究助成 

神経損傷応答分子DINEのコンディショナルノックアウトマウス作製

2006.4 - 2007.3

基礎医学医療研究助成 

損傷運動ニューロンの生と死

2005.4 - 2006.4

学内共同研究 

疲労時下垂体に発現するG蛋白結合型受容体(GPCR)の機能的意義の解明へ向けて

2005.4 - 2006.3

学内共同研究 

損傷神経軸索におけるミトコンドリアのダイナミクス

2010.4 - 2012.3

科学研究費補助金  基盤研究(C)

神経再生現象を融合する分子発現制御のメカニズムの解析

2005.4 - 2007.3

科学研究費補助金  基盤研究(B)

損傷運動ニューロンにおけるDNAメチル化と遺伝子発現制御

2004.4 - 2006.3

科学研究費補助金  若手研究(B)

グリア・ニュ ロン相互作用による神経機能維持メカニズムとその加齢変化の解析

Grant number：15082205  2003 - 2007

科学研究費助成事業  特定領域研究

木山 博資, 中込 咲綾, 小西 博之, 前田 光代, 桐生 寿美子, 濤川 一彦

損傷神経細胞におけるDINEのストレス応答機構の解析

2002.2 - 2004.3

科学研究費補助金  若手研究(B)

Neural species specific gene transfer by adenovirus vector.

Grant number：12558087  2000 - 2001

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

KIYAMA Hiroshi, NAMIKAWA Kazuhiko, SEO Sumiko

新規損傷神経関連遺伝子による生存・再生のメカニズム

Grant number：12031201  2000

特定領域研究(A)

瀬尾 寿美子

軸索損傷神経細胞の生存・再生の分子メカニズムの解析

Grant number：11157202  1999

特定領域研究(A)

瀬尾 寿美子

Spatiotemporal knockout by an Adenovirus-Targeting System.

Grant number：10044227  1998 - 2000

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A).

KIYAMA Hiroshi, SEO-KIRYU Sumiko, KATO Hidemasa

組織学

2020

基礎医学セミナー

2020

組織学

2014

人体形態学

2014

人体形態学

2014

人体形態学

2012

解剖学実習

2012

組織学

2012