研究者詳細 - 六鹿　雅登

論文 - 六鹿　雅登

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弁膜症手術症例のQOLとペースメーカ

蒔苗永, 荒木善盛, 大島英揮, 成田裕司, 阿部知伸, 六鹿雅登, 碓氷章彦

人工臓器 42 巻 ( 2 ) 頁： S - 225 2013年9月

当院におけるデバイス感染に伴うリード抜去症例の検討

成田裕司, 末永啓人, 大野司, 岡田典隆, 蒔苗永, 寺澤幸枝, 徳田順之, 岡田正穂, 六鹿雅登, 藤本和朗, 荒木善盛, 阿部知伸, 大島英揮, 碓氷章彦

人工臓器 42 巻 ( 2 ) 頁： S - 225 2013年9月

Detection of thoracic aortic prosthetic graft infection with 18F-fluorodeoxyglucose positron emission tomography/computed tomography 査読有り

Yoshiyuki Tokuda, Hideki Oshima, Yoshimori Araki, Yuji Narita, Masato Mutsuga, Katsuhiko Kato, Akihiko Usui

European Journal of Cardio-thoracic Surgery 43 巻 ( 6 ) 頁： 1183 - 1187 2013年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: To investigate the diagnostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in detecting thoracic aortic prosthetic graft infection. METHODS: Nine patients with clinically suspected thoracic aortic graft infection underwent FDG-PET/CT scanning. In these patients, the diagnoses could not be confirmed using conventional modalities. The patients' clinical courses were retrospectively reviewed. RESULTS: On the basis of surgical, microbiological and clinical follow-up findings, the aortic grafts were considered infected in 4 patients and not infected in 5. All 4 patients with graft infection (root: 2 cases, arch: 1 case and descending: 1 case) eventually underwent in situ re-replacement. Two of the 4 patients also had abdominal grafts
however, only the thoracic grafts were replaced because uptake was low around the abdominal grafts. The maximal standardized uptake value (SUVmax) in the perigraft area was higher in the infected group than in the non-infected group (11.4 ± 4.5 vs 6.9 ± 6.4), although the difference was not statistically significant. According to the receiver operating characteristic analysis, SUVmax &gt
8 appeared to be the cut-off value in distinguishing the two groups (sensitivity: 1.0 and specificity: 0.8). CONCLUSIONS: FDG-PET/CT is useful for confirming the presence of graft infection by detecting high uptake around grafts and excluding other causes of inflammation. An SUVmax value greater than 8 around a graft suggests the presence of graft infection. In addition, FDG-PET/CT can be used to clarify the precise extent of infection. This is especially useful if multiple separated prosthetic grafts have been implanted. © The Author 2013. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

DOI： 10.1093/ejcts/ezs693

Scopus

PubMed

金型使用による自己心膜のglutaraldehyde処理を行った弓部パッチによるNorwood手術

櫻井一, 阿部知伸, 櫻井寛久, 杉浦純也, 寺田貴史, 種市哲吉, 六鹿雅登

日本心臓血管外科学会雑誌 42 巻 ( Suppl. ) 頁： 215 - 215 2013年2月

[Recurrence of cardiac myxoma in the left atrial after 28 years; report of a case].

Takanohashi A, Usui A, Mutsuga M, Tokuda Y, Araki Y, Narita Y, Oshima H, Ueda Y

Kyobu geka. The Japanese journal of thoracic surgery 65 巻 ( 12 ) 頁： 1089 - 92 2012年11月

Fast-track extubation after modified Fontan procedure. 査読有り

Mutsuga M, Quiñonez LG, Mackie AS, Norris CM, Marchak BE, Rutledge JM, Rebeyka IM, Ross DB

The Journal of thoracic and cardiovascular surgery 144 巻 ( 3 ) 頁： 547 - 52 2012年9月

The Clinical Outcomes of Prolonged Donor Ischemic Time in Adult Patients Undergoing Heart Transplantation. A Single Center Experiences in Canada

Mutsuga M., Wang S., MacArthur R., Mullen J., Modry D., Ross D., Meyer S.

JOURNAL OF HEART AND LUNG TRANSPLANTATION 31 巻 ( 4 ) 頁： S93 - S94 2012年4月

Biodegradable nanofibers in cardiovascular medicine: Drug delivery application

Mutsuga M., Yamawaki-Ogata A., Satake M., Kaneko H., Ueda Y., Narita Y.

Nanomedicine and the Cardiovascular System 頁： 345 - 369 2011年1月

記述言語：英語掲載種別：論文集(書籍)内論文出版者・発行元：Nanomedicine and the Cardiovascular System

Nanotechnology will play a great role in the field of cardiovascular disease in the near future. It will be a very useful tool in drug delivery approaches to treat cardiovascular disease. Nanomedicine (medical treatment using nanotechnology) can be considered a refinement of molecular medicine and integrates advances in genomics and proteomics to facilitate the development of personalized medicine. Nanomedicine for cardiovascular disease has focused on materials at super-molecular levels to deliver increased therapeutic efficacy and diminish adverse effects, which have ultimately resulted in their clinical application. All the aforementioned developments have revolutionized the application of nanotechnologies and have led to improved understanding of the possibilities for drug delivery to diseased tissues and organs. In this chapter we introduce a novel drug delivery system (DDS) using biodegradable nano-scaled fiber for use in cardiovascular medicine. Occasionally, systemic administration of the drug for cardiovascular diseases not only fails to work sufficiently, but also causes adverse side effects due to the limited effective threshold of the drug. Therefore, these medicines may need to be released locally and gradually. Our newly developed DDS applied biodegradable polymer mixed with a drug used for surgical treatment of cardiovascular diseases, to achieve sustained release. The mechanisms of sustained release of a drug are quite simple; the drug is released with diffusion, hydrolysis of the biodegradable polymer and/or degradation of polymer by enzymatic or phagocytotic effects in vivo. An electrospinning procedure is used to fabricate the nanofiber configurations for these materials. In this chapter, we review the DDS scaffold using electrospinning nanofiber technology, and also highlight our recent results using our new DDS with biodegradable nano-scaled fiber for cardiovascular diseases to prevent anastomotic stricture and treat aortic aneurysm.

Scopus

Spinal cord protection during a thoracoabdominal aortic repair for a chronic type B aortic dissection using the aortic tailoring strategy 査読有り

Mutsuga Masato, Narita Yuji, Araki Yoshimori, Maekawa Atsuo, Oshima Hideki, Usui Akihiko, Ueda Yuichi

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY 11 巻 ( 1 ) 頁： 15 - 18 2010年7月

Effects of Extracellular Matrix on Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells into Smooth Muscle Cell Lineage: Utility for Cardiovascular Tissue Engineering 査読有り

Suzuki Shuichi, Narita Yuji, Yamawaki Aika, Murase Yosuke, Satake Makoto, Mutsuga Masato, Okamoto Hideki, Kagami Hideaki, Ueda Minoru, Ueda Yuichi

CELLS TISSUES ORGANS 191 巻 ( 4 ) 頁： 269 - 280 2010年

Development of novel drug-eluting biodegradable nano-fiber for prevention of postoperative pulmonary venous obstruction. 査読有り

Mutsuga M, Narita Y, Yamawaki A, Satake M, Kaneko H, Usui A, Ueda Y

Interactive cardiovascular and thoracic surgery 8 巻 ( 4 ) 頁： 402 - 6; discussion 406 2009年4月

A new strategy for prevention of anastomotic stricture using tacrolimus-eluting biodegradable nanofiber 査読有り

Mutsuga Masato, Narita Yuji, Yamawaki Aika, Satake Makoto, Kaneko Hiroaki, Suematsu Yoshihiro, Usui Akihiko, Ueda Yuichi

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 137 巻 ( 3 ) 頁： 703 - 709 2009年3月

補助循環・人工肺・体外循環

阿部裕輔, 奥村高広, 岩田英理子, 六鹿雅登, 磯山隆

人工臓器 35 巻 ( 2 ) 頁： S171 - S173 2006年

Acute occlusion of left coronary ostium associated with congenital quadricuspid aortic valve. 査読有り

Mutsuga M, Tamaki S, Yokoyama Y, Kato N, Yokote J, Ohata N, Suzuki T

The Annals of thoracic surgery 79 巻 ( 5 ) 頁： 1760 - 1 2005年5月

Pseudoaneurysm from the mitral-aortic intervalvular fibrosa following endocarditis. 査読有り

Yokoyama Y, Tamaki S, Kato N, Yokote J, Mutsuga M

The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi 51 巻 ( 8 ) 頁： 374 - 7 2003年8月

新生児・乳児の人工心肺に対する血液浄化法の工夫充填血液に対するSingle Pass HDF及び持続的HDFの効果

小山富生, 玉木修治, 横山幸房, 加藤紀之, 横手淳, 六鹿雅登

The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY 50 巻 ( Suppl. ) 頁： 283 - 283 2002年9月

PCPS長期補助例における血液浄化の有用性

横山幸房, 玉木修治, 伊藤正夫, 加藤紀之, 横手淳, 六鹿雅登, 岡田正穂, 小山富生, 山田哲也, 片山浩司

ICUとCCU 25 巻 ( 12 ) 頁： 974 - 975 2001年12月

Right atrial myxoma associated with atrial septal defect: a case report and review of the literature 査読有り

H Murayama, S Tamaki, N Kato, N Yuji, J Yokote, M Mutsuga, M Okada

Ann Thorac Cardiovasc Surg 7 巻 ( 3 ) 頁： 166 - 169 2001年6月

Repair of intercostal arteries in thoracoabdominal aneurysm 査読有り

Y. Yokoyama, S. Tamaki, M. Ito, N. Kato, J. Yokote, M. Mutsuga, M. Okada

Asian Cardiovascular and Thoracic Annals 9 巻 ( 3 ) 頁： 221 - 222 2001年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Asia Publishing Exchange Pte Ltd

A parallel aortic graft composed of a 20-mm graft with two 10-mm accessory grafts was used in the repair of a large thoracoabdominal aneurysm in a 50-year-old man. The graft was attached to 6 intercostal arteries and used immediately for spinal cord perfusion before repairing the aneurysm. The patient recovered quickly without paraplegia.

DOI： 10.1177/021849230100900315

Scopus

体外循環におけるbronchial returnの左室ベント流量に及ぼす影響

成田裕司, 玉木修治, 横山幸房, 加藤紀之, 横手淳, 六鹿雅登, 岡田雅穂, 小山富生, 山田哲也, 片山浩司

人工臓器 29 巻 ( 3 ) 頁： S - 99 2000年8月

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