Updated on 2024/04/03

写真a

 
MUTSUGA Masato
 
Organization
Graduate School of Medicine Program in Integrated Medicine Musculoskeletal and Cutaneous Medicine Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Professor

Degree 1

  1. 医学博士 ( 2009.3   名古屋大学 ) 

Research Interests 6

  1. ventricular assist device

  2. minimally invasive cardiac surgery

  3. mitral valve surgery

  4. aortic surgery

  5. Drug eluting device

  6. Shape memory polymer

Research Areas 2

  1. Life Science / Cardiovascular surgery  / nanofiber

  2. Life Science / Cardiovascular surgery

Research History 7

  1. Nagoya University   Department of Cardiac Surgery   Associate professor

    2020.1

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    Country:Japan

  2. Nagoya University   Cardiac Surgery   Lecturer

    2018.6

  3. Nagoya University   Cardiac Surgery   Lecturer of hospital

    2014.4 - 2018.5

  4. Nagoya University   Cardiac Surgery   Designated assistant professor

    2011.7 - 2014.3

  5. University of Alberta   Clinical fellow of Cardiac Surgery   Clinical fellow

    2009.7 - 2011.6

  6. Nagoya University   Cardiac Surgery

    2006.10 - 2009.6

  7. Ogaki municipal hospital   CardioThoracic Surgery

    1996.5 - 2006.9

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Education 2

  1. Nagoya University   Graduate School of Medicine   Cardiac Surgery

    2005.4 - 2009.3

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    Country: Japan

  2. Nagoya University   Graduate School, Division of Medicine

    1990.4 - 1996.3

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    Country: Japan

Professional Memberships 7

  1. THE JAPANESE ASSOCIATION FOR THORACIC SURGERY

  2. THE JAPAN SOCIETY FOR TRANSPLANTATION

  3. THE JAPANESE SOCIETY FOR CARDIOVASCULAR SURGERY

  4. The Japanese Circulation Society

  5. JAPANESE SOCIETY OF PEDIATRIC CARDIOLOGY AND CARDIAC SURGERY

  6. JAPAN SURGICAL SOCIETY

  7. JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

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Papers 247

  1. Patient management important for long-term support beyond 5 years in the BTT: republication of the article published in the Japanese Journal of Artificial Organs.

    Mutsuga M

    Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs     2024.3

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    Language:English  

    DOI: 10.1007/s10047-024-01441-3

    PubMed

  2. Thromboelastographic evaluation after cardiac surgery optimizes transfusion requirements in the intensive care unit: a single-center retrospective cohort study using an inverse probability weighting method

    Tamura, T; Suzuki, S; Fujii, T; Hirai, T; Imaizumi, T; Kubo, Y; Shibata, Y; Narita, Y; Mutsuga, M; Nishiwaki, K

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   Vol. 72 ( 1 ) page: 15 - 23   2024.1

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  3. Impact of aortopulmonary collaterals on adverse events after total cavopulmonary connection

    Osawa, T; Schaeffer, T; Borgmann, K; Schmiel, M; Staehler, H; Di Padua, C; Heinisch, PP; Piber, N; Mutsuga, M; Hager, A; Ewert, P; Hörer, J; Ono, M

    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY   Vol. 64 ( 6 )   2023.12

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  4. Development of novel waxy bone haemostatic agents composed of biodegradable polymers with osteogenic-enhancing peptides in rabbit models

    Ohno, T; Suenaga, H; Yamawaki-Ogata, A; Kanie, K; Kato, R; Uto, K; Ebara, M; Ito, H; Narita, Y; Usui, A; Mutsuga, M

    INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY   Vol. 37 ( 5 )   2023.11

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  5. Surgical reconstruction after resection of cardiac metastasis from oropharyngeal carcinoma: a case report

    Nishi, T; Fujimoto, KL; Hiramatsu, M; Okada, T; Suzuki, Y; Shimoyama, Y; Terazawa, S; Tokuda, Y; Mutsuga, M; Usui, A

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 85 ( 4 ) page: 875 - 879   2023.11

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  6. Hypopharyngeal Injury by Transesophageal Echocardiography During Cardiac Surgery

    Aoki, Y; Tamura, T; Uchida, W; Morioka, H; Yamamoto, M; Yuhara, S; Nishio, N; Mutsuga, M; Furune, S; Suzuki, S; Nishiwaki, K

    JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA   Vol. 37 ( 10 ) page: 2027 - 2031   2023.10

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  7. Cadaver surgical training for brain-dead donor lung procurement: Educational note

    Nakamura, S; Ueno, H; Mutsuga, M; Chen-Yoshikawa, TF

    JTCVS TECHNIQUES   Vol. 21   page: 261 - 264   2023.10

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  8. Fabrication of pH-responsive poly(vinyl alcohol)-based microfibers crosslinked with copolymers containing benzoxaborole and carboxy groups

    Momose, T; Takeuchi, K; Uchida, H; Saito, S; Nakada, K; Mutsuga, M; Yamawaki-Ogata, A; Narita, Y; Kotsuchibashi, Y

    POLYMER   Vol. 283   2023.9

  9. [Perioperative Management of Coagulation After the Weaning of Cardiopulmonary Bypass in Cardiac Surgery].

    Mutsuga M

    Kyobu geka. The Japanese journal of thoracic surgery   Vol. 76 ( 10 ) page: 824 - 828   2023.9

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    Language:Japanese  

    PubMed

  10. A review of current status of cell-based therapies for aortic aneurysms

    Yamawaki-Ogata, A; Mutsuga, M; Narita, Y

    INFLAMMATION AND REGENERATION   Vol. 43 ( 1 ) page: 40   2023.8

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  11. Transcatheter Aortic Valve Replacement for Bicuspid Aortic Stenosis With a Severely Calcified Raphe Using An Under-Sized SAPIEN 3 Valve: Sizing by the Circle Method and Deployment by the Pressure-Regulated Method

    Tobe, A; Tanaka, A; Tokuda, Y; Shirai, Y; Miyazaki, T; Yuhara, S; Akita, S; Furusawa, K; Ishii, H; Mutsuga, M; Murohara, T

    CARDIOVASCULAR REVASCULARIZATION MEDICINE   Vol. 53   page: S149 - S152   2023.8

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  12. Hybrid Repair of Extensive Aortic Arch Aneurysms: Outcomes of Isolated Frozen Elephant Trunk Repair and of Elephant Trunk with Second Stage Thoracic Endovascular Aortic Repair

    Tokuda, Y; Terazawa, S; Yoshizumi, T; Ito, H; Banno, H; Mutsuga, M

    EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY   Vol. 66 ( 2 ) page: 284 - 285   2023.8

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  13. Cardiac rehabilitation in a heart-failure patient using customized "cardiac support net" treatment: a case report

    Kobayashi, K; Akita, T; Akita, S; Ito, H; Terazawa, S; Mutsuga, M; Usui, A

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 85 ( 3 ) page: 626 - 634   2023.8

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  14. Incidence and clinical impact of silent pancreatitis after aortic arch surgery

    Ohno, T; Mutsuga, M; Saito, S; Tokuda, Y; Nagai, K; Umemoto, N; Abe, T; Usui, A

    ASIAN CARDIOVASCULAR & THORACIC ANNALS   Vol. 31 ( 4 ) page: 303 - 311   2023.5

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  15. Contractile pericarditis-like hemodynamics in dilated-phase hypertrophic cardiomyopathy with giant atrium.

    Morimoto R, Ito R, Araki T, Mizutani T, Kimura Y, Kazama S, Oishi H, Kuwayama T, Sugiura Y, Hiraiwa H, Kondo T, Okumura T, Kobayashi K, Mutsuga M, Murohara T

    Journal of cardiology cases   Vol. 27 ( 5 ) page: 199 - 202   2023.5

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    Language:English  

    DOI: 10.1016/j.jccase.2023.01.005

    PubMed

  16. Clinical implications of the cardio-ankle vascular index before and after transcatheter aortic valve implantation

    Miki, Y; Tanaka, A; Tokuda, Y; Tobe, A; Shirai, Y; Yuhara, S; Akita, S; Furusawa, K; Ishii, H; Mutsuga, M; Murohara, T

    JOURNAL OF CARDIOVASCULAR MEDICINE   Vol. 24 ( 5 ) page: 302 - 307   2023.5

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  17. Increased risk of purge system malfunction after Impella 5.0 replacement: a case series

    Oishi, H; Morimoto, R; Ito, R; Kazama, S; Kimura, Y; Araki, T; Mizutani, T; Kuwayama, T; Hiraiwa, H; Kondo, T; Okumura, T; Mutsuga, M; Usui, A; Murohara, T

    JOURNAL OF ARTIFICIAL ORGANS   Vol. 26 ( 1 ) page: 79 - 83   2023.3

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  18. Administration of anti-inflammatory M2 macrophages suppresses progression of angiotensin II-induced aortic aneurysm in mice

    Ashida, S; Yamawaki-Ogata, A; Tokoro, M; Mutsuga, M; Usui, A; Narita, Y

    SCIENTIFIC REPORTS   Vol. 13 ( 1 ) page: 1380   2023.1

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  19. Impact of Albuminuria on the Prognosis After Transcatheter Aortic Valve Implantation

    Tobe, A; Tanaka, A; Tokuda, Y; Shirai, Y; Miyazaki, T; Yuhara, S; Akita, S; Furusawa, K; Ishii, H; Mutsuga, M; Murohara, T

    AMERICAN JOURNAL OF CARDIOLOGY   Vol. 186   page: 156 - 162   2023.1

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  20. Higher F-wave frequency associates with poor procedural success rate after Maze procedure

    Usui, R; Mutsuga, M; Narita, Y; Tokuda, Y; Terazawa, S; Ito, H; Uchida, W; Inden, Y; Murohara, T; Usui, A

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   Vol. 70 ( 12 ) page: 997 - 1004   2022.12

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  21. Effectiveness of the scheduled transfusion strategy for factor V deficiency with platelet dysfunction during coronary artery surgery

    Morita, K; Mutsuga, M; Uchida, W; Usui, A

    JOURNAL OF CARDIAC SURGERY   Vol. 37 ( 12 ) page: 5493 - 5495   2022.12

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  22. Methods for confirming the safety of radiation therapy in patients with left ventricular assist device: a case of extranodal NK/T-cell lymphoma, nasal type

    Oishi, H; Kondo, T; Kawamura, M; Shimada, K; Mutsuga, M; Kurokawa, T; Kuwayama, T; Hiraiwa, H; Morimoto, R; Okumura, T; Nishida, T; Kiyoi, H; Naganawa, S; Usui, A; Murohara, T

    JOURNAL OF ARTIFICIAL ORGANS   Vol. 25 ( 3 ) page: 274 - 278   2022.9

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  23. [Traumatic Thoracic Aortic Injury].

    Mutsuga M

    Kyobu geka. The Japanese journal of thoracic surgery   Vol. 75 ( 10 ) page: 759 - 762   2022.9

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    Language:Japanese  

    PubMed

  24. Multiple giant coronary artery aneurysms with extended coronary ectasia emerging 12years after previous coronary artery bypass grafting

    Fujii, T; Mutsuga, M; Narita, Y; Tokuda, Y; Terazawa, S; Ito, H; Uchida, W; Yuhara, S; Usui, A

    SAGE OPEN MEDICAL CASE REPORTS   Vol. 10   page: 2050313X221116681   2022.8

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  25. Lateralized Purplish Skin Discoloration Due to Aortic Dissection.

    Ishida S, Mutsuga M, Fujita T, Yagami K

    Circulation reports   Vol. 4 ( 7 ) page: 332   2022.7

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    Language:English  

    DOI: 10.1253/circrep.CR-22-0018

    PubMed

  26. Surgical techniques for infectious endocarditis of the mitral valve with hypertrophic cardiomyopathy in Costello syndrome.

    Ishida S, Mutsuga M, Fujita T, Yagami K

    Journal of cardiology cases   Vol. 25 ( 6 ) page: 367 - 369   2022.6

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    DOI: 10.1016/j.jccase.2021.12.010

    PubMed

  27. Flexion limitation of the Impella 5.0 when implanted using the femoral approach in patients with small stature

    Hiraiwa, H; Kimura, Y; Morimoto, R; Ito, R; Araki, T; Mizutani, T; Kazama, S; Oishi, H; Kuwayama, T; Kondo, T; Furusawa, K; Okumura, T; Mutsuga, M; Usui, A; Murohara, T

    JOURNAL OF ARTIFICIAL ORGANS   Vol. 25 ( 2 ) page: 182 - 183   2022.6

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  28. Plaster technique for filling up a future entry at the suture hole in type A aortic dissection

    Ishida, S; Mutsuga, M; Fujita, T; Yagami, K

    INDIAN JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY   Vol. 38 ( 3 ) page: 339 - 341   2022.5

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  29. Impella5.0 "ILIPELLA" Approach for a Fulminant Myocarditis Patient With a Small Peripheral Artery

    Mutsuga, M; Banno, H; Okumura, T; Morimoto, R; Kondo, T; Kimura, Y; Hiraiwa, H; Murohara, T; Usui, A

    HEART LUNG AND CIRCULATION   Vol. 31 ( 5 ) page: E72 - E74   2022.5

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  30. Impact of an Improved Standardized Strategy and Individually Tailored Protocol for Heartmate II and Heartmate 3 Left Ventricular Assist Devices on the Incidence of Driveline Infections

    Mutsuga, M; Okumura, T; Morimoto, R; Kondo, T; Ito, H; Uchida, W; Terazawa, S; Tokuda, Y; Narita, Y; Murohara, T; Usui, A

    JOURNAL OF HEART AND LUNG TRANSPLANTATION   Vol. 41 ( 4 ) page: S489 - S489   2022.4

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  31. Relationship between spleen size and exercise tolerance in advanced heart failure patients with a left ventricular assist device

    Hiraiwa, H; Okumura, T; Sawamura, A; Araki, T; Mizutani, T; Kazama, S; Kimura, Y; Shibata, N; Oishi, H; Kuwayama, T; Kondo, T; Furusawa, K; Morimoto, R; Adachi, T; Yamada, S; Mutsuga, M; Usui, A; Murohara, T

    BMC RESEARCH NOTES   Vol. 15 ( 1 ) page: 40   2022.2

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  32. Late detection of communication between juxtaposed atrial appendages

    Ishida, S; Mutsuga, M; Fujita, T; Yagami, K

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   Vol. 70 ( 2 ) page: 190 - 192   2022.2

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  33. Alternative therapeutic strategy for existing aortic aneurysms using mesenchymal stem cell-derived exosomes

    Kozakai, M; Narita, Y; Yamawaki-Ogata, A; Fujimoto, KL; Mutsuga, M; Tokuda, Y; Usui, A

    EXPERT OPINION ON BIOLOGICAL THERAPY   Vol. 22 ( 1 ) page: 95 - 104   2022.1

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  34. Late-phase left ventricular pseudoaneurysm after three-time mitral valve surgery

    Ishida, S; Mutsuga, M; Fujita, T; Yagami, K

    JOURNAL OF SURGICAL CASE REPORTS   Vol. 2022 ( 1 )   2022.1

  35. Surgical Management for Systolic Anterior Motion (SAM) of the Mitral Valve in Obstructive Hypertrophic Myopathy

    Usui, A; Mutsuga, M

    ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY   Vol. 28 ( 4 ) page: 239 - 248   2022

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  36. Comparison of Impella 5.0 and extracorporeal left ventricular assist device in patients with cardiogenic shock

    Kondo, T; Morimoto, R; Mutsuga, M; Fujimoto, K; Okumura, T; Shibata, N; Kazama, S; Kimira, Y; Oishi, H; Kuwayama, T; Hiraiwa, H; Usui, A; Murohara, T

    INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS   Vol. 44 ( 11 ) page: 846 - 853   2021.11

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  37. Sudden circulatory collapse caused by mechanical obstruction of the left main coronary trunk with infective endocarditis vegetation: a case report

    Usui, R; Mutsuga, M; Narita, Y; Tokuda, Y; Terazawa, S; Ito, H; Uchida, W; Usui, A

    SURGICAL CASE REPORTS   Vol. 7 ( 1 ) page: 223   2021.10

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  38. "Double Cuff" Technique for Modified Bentall Procedure.

    Mutsuga M, Usui A

    Heart, lung & circulation     2021.5

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    DOI: 10.1016/j.hlc.2021.05.073

    PubMed

  39. Predictors of failure of mitral valve repair using artificial chordae.

    Mutsuga M, Narita Y, Tokuda Y, Uchida W, Ito H, Terazawa S, Nakaguro M, Usui A

    The Annals of thoracic surgery     2021.5

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    DOI: 10.1016/j.athoracsur.2021.04.084

    PubMed

  40. Pericardioperitoneal and pericardiopleural windows: A drainage technique for the treatment of recurrent cardiac tamponade. A case report.

    Ishida S, Yagami K, Fujita T, Mutsuga M

    International journal of surgery case reports   Vol. 83   page: 105962   2021.5

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    DOI: 10.1016/j.ijscr.2021.105962

    PubMed

  41. "Millefeuille Technique" by Using Excised Intimal Layers in Repair of Type A Aortic Dissection.

    Mutsuga M, Yagami K, Fujita T, Ishida S, Usui A

    Heart, lung & circulation     2021.4

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    DOI: 10.1016/j.hlc.2021.04.003

    PubMed

  42. A surgical case for pregnancy-related spontaneous coronary artery dissection.

    Usui R, Mutsuga M, Yoshizumi T, Oshima H, Usui A

    The Annals of thoracic surgery     2021.4

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    DOI: 10.1016/j.athoracsur.2021.04.023

    PubMed

  43. Midterm Outcomes of Zone 0 Antegrade Endograft Implantation During Type I Hybrid Aortic Arch Repair.

    Banno H, Mutsuga M, Sugimoto M, Tokuda Y, Kodama A, Usui A, Komori K

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     2021.3

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    DOI: 10.1016/j.ejvs.2021.02.044

    PubMed

  44. Coronary artery aneurysm complicated by pneumothorax with a history of Kawasaki disease

    Ishida Shinichi, Mutsuga Masato, Fujita Takashi, Ito Masao, Okamoto Sawako, Yagami Kei

    JOURNAL OF SURGICAL CASE REPORTS   Vol. 2021 ( 3 ) page: rjab053   2021.3

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  45. [Surgical treatment for aortic root dilatation and aortic regurgitation after arterial switch operation].

    Mutsuga M, Tamaki S, Yokoyama Y, Ishikawa H, Ishimoto N, Usui A, Ueda Y

    Kyobu geka. The Japanese journal of thoracic surgery   Vol. 61 ( 12 ) page: 1043 - 7   2008.11

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    PubMed

  46. Factors associated with postsurgical muscle weakness in patients who undergo thoracic aortic surgery: a retrospective cohort study. International journal

    Miho Shimizu, Takuji Adachi, Kiyonori Kobayashi, Masato Mutsuga, Hideki Oshima, Akihiko Usui, Sumio Yamada

    Physiotherapy theory and practice   Vol. 39 ( 10 ) page: 2180 - 2188   2023.10

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    OBJECTIVE: Aortic surgery is often performed in elderly patients, and these patients have a high risk of postsurgical muscle weakness. To reinforce purposeful postsurgical rehabilitation, we aimed to investigate the factors associated with postsurgical muscle weakness in patients who underwent thoracic aortic surgery. METHODS: This retrospective cohort study analyzed data of consecutive patients who underwent elective thoracic aortic surgery with cardiopulmonary bypass, and whose knee extensor isometric muscle strength (KEIS) were measured pre- and postoperatively at University Hospital between January 2012 and December 2018. The primary outcome was percent change in KEIS (% change in KEIS). Multivariate linear regression analysis was used to identify independent risk factors for % change in KEIS. RESULTS: Overall, 218 patients were included. Multivariate linear regression analysis showed that mechanical ventilation time, days from initial sitting to 100 m walking, and the number of exercises in the rehabilitation room were associated with % change in KEIS. CONCLUSIONS: This study may serve as a reference to stratify patients at risk of postsurgical muscle weakness. The preventive or alternative interventions in patients undergoing thoracic aortic surgery will be assessed in future studies.

    DOI: 10.1080/09593985.2022.2068168

    Web of Science

    PubMed

  47. Cardiac rehabilitation in a heart failure patient using customized “cardiac support net” treatment: A case report Reviewed

    Kiyonori Kobayashi, Toshiaki Akita, Sho Akita, Hideki Ito, Sachie Terazawa, Masato Mutsuga, Akihiko Usui

    Nagoya J Med Sci   Vol. 85 ( 3 ) page: 626 - 634   2023.8

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  48. Cardiac Rehabilitation in Severe Heart Failure Patients with Impella 5.0 Support via the Subclavian Artery Approach Prior to Left Ventricular Assist Device Implantation

    Miho Shimizu, Hiroaki Hiraiwa, Shinya Tanaka, Yohei Tsuchikawa, Ryota Ito, Shingo Kazama, Yuki Kimura, Takashi Araki, Takashi Mizutani, Hideo Oishi, Tasuku Kuwayama, Toru Kondo, Ryota Morimoto, Takahiro Okumura, Hideki Ito, Tomo Yoshizumi, Masato Mutsuga, Akihiko Usui, Toyoaki Murohara

    Journal of Personalized Medicine   Vol. 13 ( 4 ) page: 630 - 630   2023.4

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:MDPI AG  

    Impella 5.0 circulatory support via subclavian artery (SA) access may be a safe approach for patients undergoing cardiac rehabilitation (CR). In this case series, we retrospectively analyzed the demographic characteristics, physical function, and CR data of six patients who underwent Impella 5.0 implantation via the SA prior to left ventricular assist device (LVAD) implantation between October 2013 and June 2021. The median age was 48 years, and one patient was female. Grip strength was maintained or increased in all patients before LVAD implantation (pre-LVAD) compared to after Impella 5.0 implantation. The pre-LVAD knee extension isometric strength (KEIS) was less than 0.46 kgf/kg in two patients and more than 0.46 kgf/kg in three patients (unavailable KEIS data, n = 1). With Impella 5.0 implantation, two patients could ambulate, one could stand, two could sit on the edge of the bed, and one remained in bed. One patient lost consciousness during CR due to decreased Impella flow. There were no other serious adverse events. Impella 5.0 implantation via the SA allows mobilization, including ambulation, prior to LVAD implantation, and CR can be performed relatively safely.

    DOI: 10.3390/jpm13040630

    Web of Science

    PubMed

  49. Impact of an improved driveline management for HeartMate II and HeartMate 3 left ventricular assist devices. International journal

    Masato Mutsuga, Takahiro Okumura, Ryota Morimoto, Toru Kondo, Hideki Ito, Sachie Terazawa, Yoshiyuki Tokuda, Yuji Narita, Kazuki Nishida, Toyoaki Murohara, Akihiko Usui

    Artificial organs   Vol. 47 ( 2 ) page: 387 - 395   2023.2

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    BACKGROUND: We evaluated the impact of a standardized driveline care strategy, including a subfascial-tunneling method and dressing protocol, on the incidence of driveline infection (DLI). METHODS: DLI data from all HeartMate II (HMII) and HeartMate 3 (HM3) patients (including exchange devices) were retrospectively collected between 2013 and 2021. The driveline subfascial-tunneling method was altered in three steps (A: right direct; B: left triple, C: right triple), and the shower protocol was changed in two steps (A: with/without cover, B: with cover). Disinfection was individually tailored after changing the shower protocol. Complications associated with morbidity and mortality were evaluated for each modification. RESULTS: During the study period, 80 devices were implanted (HMII, n = 54; HM3, n = 26). The 8-year incidence of DLI was 15% (n = 8) in HMII patients and 0% in HM3 patients (p = 0.039). DLI was not associated with hospital mortality. The modified dressing protocol and tunneling method was associated with a significantly better DLI incidence rate in comparison to the previous one: Protocol-A (n = 17), Protocol-B (n = 63), 35% vs 3% (p = 0.0009), Method-A (n = 13), Method-B (n = 42), Method-C (n = 25), 46% vs 5% vs 0% (p = 0.0001). The rete of freedom form DLI at 1, 2, and 3 years had also significant difference between groups: Protocol-A and Protocol-B, 80%, 54%, 54% vs 96%, 96%, 96%, respectively (p < 0.0001), Method-A, Method-B and Method-C, 76%, 44%, 44%, vs 94%, 94%, 94% vs 100%, 100%, respectively (p < 0.0001). CONCLUSIONS: A standardized triple driveline tunneling strategy and waterproof dressing protocol reduced driveline infection in HM3 patients to 0%.

    DOI: 10.1111/aor.14426

    Web of Science

    PubMed

  50. Impact of Early Ambulation on the Prognosis of Coronary Artery Bypass Grafting Patients.

    Yohei Tsuchikawa, Yoshiyuki Tokuda, Hideki Ito, Miho Shimizu, Shinya Tanaka, Kazuki Nishida, Daichi Takagi, Akimasa Fukuta, Natsuki Takeda, Hiromasa Yamamoto, Masaya Hori, Yoshihiro Nishida, Masato Mutsuga

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 87 ( 2 ) page: 306 - +   2023.1

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    BACKGROUND: The effect of delayed ambulation on the outcome of coronary artery bypass grafting (CABG) remains to be clarified.Methods and Results: The long-term and in-hospital outcomes of 887 patients who underwent isolated CABG (455 off-pump cases, 135 urgent cases) were evaluated, with a focus on the timing of first ambulation. In-hospital mortality cases were excluded. Early ambulation (first ambulation within 3 days after operation) was achieved in 339 (38%) patients. In the multivariable logistic regression analysis, longer operation time and urgent case, EuroSCORE II, re-thoracotomy, and respiratory time were associated with delayed (≥4 days) ambulation. Delayed ambulation was associated with a high incidence of postoperative complications, such as pneumonia, and stroke (P<0.01). Following discharge, 22.2% of patients experienced major cardiac events and 13.8% died during the follow-up period (median follow-up 60 months). Cox hazards analysis revealed that delayed ambulation was associated with long-term adverse events (hazard ratio 1.04 per day, P<0.001). With adjustment for preoperative factors, the estimated future risk of adverse events was found to be increased day-by-day during the delay until initial ambulation. CONCLUSIONS: In isolated CABG patients, delayed ambulation was associated with poor outcomes, even in the long-term period. The results support the current guideline recommending early ambulation protocol after cardiac surgery.

    DOI: 10.1253/circj.CJ-22-0416

    Web of Science

    PubMed

  51. Relationship between muscle strength and rehospitalization in ventricular assist device patients. International journal

    Kiyonori Kobayashi, Masato Mutsuga, Akihiko Usui

    Scientific reports   Vol. 12 ( 1 ) page: 50 - 50   2022.1

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    We examined the relationship between leg extensor muscle strength (LEMS) at discharge and rehospitalization within 1 year in patients with a newly implanted ventricular assist device (VAD). This study included 28 patients who had received a VAD at our institution between October 2013 and February 2019, all of whom had been discharged for 1 year. The patients were divided into two groups according to their LEMS at discharge (higher strength [group H] and lower strength [group L]), based on the median value of the 55.2 kg-force (kgf)/body weight (BW) equation. Exercise performance parameters (e.g., grip strength, 6-min walk distance, and peak VO2) and laboratory data concerning nutritional status were also collected. Nine patients (64.3%) in group L were rehospitalized within 1 year after discharge. The rehospitalization rate was significantly higher in group L than group H (p = 0.020). Compared with discharge, patients exhibited higher grip strength (56.3 vs. 48.6 kg/BW, respectively; p = 0.011), 6-min walk distances (588 vs. 470 m, respectively; p = 0.002), and peak VO2 (15.4 vs. 11.9 mL/min/kg, respectively; p < 0.001) at 1 year after discharge. However, the LEMS (57.4 vs. 58.0 kgf/BW, respectively; p = 0.798) did not increase after discharge in VAD patients who avoided rehospitalization. LEMS at discharge was associated with rehospitalization after VAD surgery; a high LEMS improves the likelihood of avoiding rehospitalization.

    DOI: 10.1038/s41598-021-04002-3

    Web of Science

    PubMed

  52. 胸部大動脈手術患者における術後筋力低下の関連因子

    清水 美帆, 足立 拓史, 小林 聖典, 六鹿 雅登, 大島 英揮, 碓氷 章彦, 山田 純生

    日本臨床生理学会雑誌   Vol. 51 ( 4 ) page: 60 - 60   2021.10

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  53. 左室補助人工心臓患者における6分間歩行距離の遠隔期成績に関する検討

    小林 聖典, 六鹿 雅登, 高木 大地, 堀 将也, 服部 慶子, 伊藤 英樹, 碓氷 章彦

    日本臨床生理学会雑誌   Vol. 51 ( 4 ) page: 60 - 60   2021.10

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  54. Left brachiocephalic vein aneurysm: a case report

    Ueno Harushi, Yazawa Mari, Tsubouchi Hideki, Nakanishi Keita, Sugiyama Tomoshi, Kadomatsu Yuka, Goto Masaki, Ozeki Naoki, Nakamura Shota, Fukui Takayuki, Mutsuga Masato, Yoshikawa Toyofumi Fengshi Chen

    SURGICAL CASE REPORTS   Vol. 7 ( 1 ) page: 66   2021.3

  55. Associations between hemodynamic parameters at rest and exercise capacity in patients with implantable left ventricular assist devices

    Kondo Toru, Okumura Takahiro, Oishi Hideo, Arao Yoshihito, Kato Hiroo, Yamaguchi Shogo, Kuwayama Tasuku, Haga Tomoaki, Yokoi Tsuyoshi, Hiraiwa Hiroaki, Fukaya Kenji, Sawamura Akinori, Morimoto Ryota, Mutsuga Masato, Fujimoto Kazuro, Usui Akihiko, Murohara Toyoaki

    INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS   Vol. 44 ( 3 ) page: 174 - 180   2021.3

  56. Beating-heart total arch replacement for an octogenarian patient with severe heart failure

    Mutsuga Masato, Banno Hiroshi, Tokuda Yoshiyuki, Usui Akihiko

    JOURNAL OF CARDIAC SURGERY   Vol. 36 ( 3 ) page: 1126 - 1129   2021.3

  57. Beating heart left ventricle thrombectomy through mini-left-anterior thoracotomy for a patient with cardiogenic shock

    Mutsuga Masato, Usui Akihiko

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   Vol. 69 ( 3 ) page: 614 - 617   2021.3

  58. Sutures on the Anterior Mitral Leaflet to Prevent Systolic Anterior Motion.

    Tokuda Y, Fujimoto K, Narita Y, Mutsuga M, Usui A

    The Annals of thoracic surgery   Vol. 111 ( 3 ) page: e213 - e215   2021.3

  59. Predictors of residual mitral regurgitation after left ventricular assist device implantation

    Kimura Yuki, Okumura Takahiro, Kazama Shingo, Shibata Naoki, Oishi Hideo, Arao Yoshihito, Kuwayama Tasuku, Kato Hiroo, Yamaguchi Shogo, Hiraiwa Hiroaki, Kondo Toru, Morimoto Ryota, Mutsuga Masato, Fujimoto Kazuro, Usui Akihiko, Murohara Toyoaki

    INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS   Vol. 44 ( 2 ) page: 101 - 109   2021.2

  60. Hypofibrinogenemia can be estimated by the predictive formula in aortic surgery

    Nishi Toshihiko, Mutsuga Masato, Akita Toshiaki, Narita Yuji, Fujimoto Kazuro, Tokuda Yoshiyuki, Nishida Kazuki, Matsui Shigeyuki, Nishiwaki Kimitoshi, Usui Akihiko

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY     2021.1

  61. Cor triatriatum in adulthood with mitral valve regurgitation and atrial fibrillation

    Ishida Shinichi, Yagami Kei, Fujita Takashi, Mutsuga Masato

    JOURNAL OF CARDIAC SURGERY   Vol. 36 ( 1 ) page: 309 - 311   2021.1

  62. Long-term outcome 10 years after free gastroepiploic artery graft for coronary artery bypass surgery.

    Yamamoto T, Mutsuga M, Matsuura A, Miyahara K, Takemura H, Saito S, Otsuka R, Usui A

    The Annals of thoracic surgery     2020.12

  63. Aortic insufficiency associated with Impella that required surgical intervention upon implantation of the durable left ventricular assist device

    Oishi Hideo, Kondo Toru, Fujimoto Kazuro, Mutsuga Masato, Morimoto Ryota, Hirano Ken-ichi, Sawamura Akinori, Kazama Shingo, Kimura Yuki, Shibata Naoki, Kato Hiroo, Arao Yoshihito, Kuwayama Tasuku, Yamaguchi Shogo, Hiraiwa Hiroaki, Okumura Takahiro, Usui Akihiko, Murohara Toyoaki

    JOURNAL OF ARTIFICIAL ORGANS   Vol. 23 ( 4 ) page: 378 - 382   2020.12

  64. Upper thoracoabdominal aortic repair through partial posterior incision of the diaphragm via left thoracotomy

    Ito Hideki, Mutsuga Masato, Tokuda Yoshiyuki, Usui Akihiko

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   Vol. 68 ( 12 ) page: 1594 - 1595   2020.12

  65. Exclusion Technique for Entire Shaggy Aorta Followed by One-Stage Repair of the Aortic Arch and Descending Aorta

    Mutsuga Masato, Ito Hideki, Usui Akihiko

    HEART LUNG AND CIRCULATION   Vol. 29 ( 11 ) page: E269 - E272   2020.11

  66. Which is superior, the frozen elephant trunk technique alone or the classical elephant trunk technique followed by second-stage thoracic endovascular aortic repair for extensive aortic arch repair?

    Mutsuga Masato, Banno Hiroshi, Narita Yuji, Komori Kimihiro, Usui Akihiko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 4 ) page: 657 - 666   2020.11

  67. Mid-term results of Biological Bentall using a larger valve implantation technique

    Mutsuga Masato, Narita Yuji, Usui Akihiko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 4 ) page: 645 - 655   2020.11

  68. Is Hybrid Repair for an Entire Shaggy Aorta Feasible?

    Mutsuga M, Tokuda Y, Narita Y, Terazawa S, Ito H, Usui A

    Heart, lung & circulation     2020.10

  69. Do meteorological factors influence the occurrence of acute aortic dissection? A 10-year retrospective institutional study

    Usui Rena, Mutsuga Masato, Yoshizumi Tomo, Oshima Hideki, Eda Tadahito, Usui Akihiko

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY     2020.10

  70. Commentary: Continuous steady development is made by taking 2 steps forward, 1 step back.

    Mutsuga M, Chen-Yoshikawa TF

    The Journal of thoracic and cardiovascular surgery     2020.10

  71. [Covering Suture Line Using Bovine Pericardium during Mitral Valve Replacement for Third Time Infectious Endocarditis;Report of a Case].

    Ishida S, Fujita T, Yagami K, Mutsuga M

    Kyobu geka. The Japanese journal of thoracic surgery   Vol. 73 ( 11 ) page: 950 - 953   2020.10

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  72. Impella 5.0 for Cardiogenic Shock After Thrombectomy in a Patient With Intraventricular Thrombosis

    Kimura Yuki, Kondo Toru, Mutsuga Masato, Morimoto Ryota, Kazama Shingo, Shibata Naoki, Oishi Hideo, Arao Yoshihito, Kuwayama Tasuku, Kato Hiroo, Yamaguchi Shogo, Hiraiwa Hiroaki, Okumura Takahiro, Fujimoto Kazuro, Usui Akihiko, Murohara Toyoaki

    CANADIAN JOURNAL OF CARDIOLOGY   Vol. 36 ( 10 )   2020.10

  73. Surgery for anomalous papillary muscle directly into the anterior mitral leaflet. Reviewed International journal

    Masato Mutsuga, Yoshiyuki Tokuda, Kazuro Fujimoto, Sachie Terazawa, Hideki Ito, Yuji Narita, Akihiko Usui

    The Annals of thoracic surgery     2020.9

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    BACKGROUND: The anomalous insertion of papillary muscle directly into the anterior mitral leaflet is a rare congenital anomaly concomitant with hypertrophic cardiomyopathy. We herein report our surgical technique, which is designed to relieve left ventricular obstruction and preserve the mitral valve and sub-valvular apparatus. METHODS: Among 38 patients who underwent septal myectomy from 2007 to 2020, 4 had an anomalous mitral sub-valvular apparatus with papillary muscle with direct insertion into the anterior mitral leaflets. In all cases, mitral valve repair was accomplished with excision and reconstruction of all anomalous PMs, concomitant with septal myectomy. In other 34 patients, 20 cases needed mitral valve repair with regards to systolic anterior motion by hypertrophic cardiomyopathy. The comparison study was conducted between anomalous papillary muscle group (group A) and the others (group B). RESULTS: There was no early or late death in group A, three early death and two late death in group B. The mean peak gradient in the left ventricle was significantly decreased in both groups. Mitral valve regurgitation grade was also significantly decreased from 3 to 0.5 without valve replacement in group A, from 2 to 0.6 in group B. Six patients needed mitral valve replacement due to the thickness of anterior mitral leaflet in group B. CONCLUSIONS: Hypertrophic obstructive cardiomyopathy associated with the anomalous insertion of papillary muscle can be successfully treated without mitral valve replacement. Excision and reconstruction with the anomalous papillary muscle seems to be a feasible operation to reduce mitral regurgitation and relieve outflow tract obstruction.

    DOI: 10.1016/j.athoracsur.2020.07.031

    PubMed

  74. Association between splenic volume and pulsatility index in patients with left ventricular assist devices

    Hiraiwa Hiroaki, Okumura Takahiro, Sawamura Akinori, Kondo Toru, Kazama Shingo, Kimura Yuki, Shibata Naoki, Arao Yoshihito, Oishi Hideo, Kato Hiroo, Kuwayama Tasuku, Yamaguchi Shogo, Furusawa Kenji, Morimoto Ryota, Fujimoto Kazuro, Mutsuga Masato, Usui Akihiko, Murohara Toyoaki

    INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS     2020.9

  75. Efficacy of Plasma free Hemoglobin for detecting centrifugal pump thrombosis

    Kuroda Taiyo, Mutsuga Masato, Yamada Masao, Yamakawa Masato, Yuhara Satoshi, Hasegawa Hiroki, Yokote Jun, Yokoyama Yukifusa, Yamada Tetsuya, Koyama Tomio, Usui Akihiko

    PERFUSION-UK     2020.9

  76. IMPELLAとVA-ECMOの併用により管理をし得た重症心不全の一症例

    平岩 宏章, 山本 尚範, 尾崎 将之, 沼口 敦, 後藤 縁, 奥村 貴裕, 室原 豊明, 六鹿 雅登, 碓氷 章彦, 松田 直之

    日本集中治療医学会雑誌   Vol. 27 ( Suppl. ) page: 720 - 720   2020.9

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  77. Bilateral versus single internal thoracic artery grafting in hemodialysis patients

    Munakata Hisaaki, Tajima Kazuyoshi, Kato Wataru, Tanaka Keisuke, Tokuda Yoshiyuki, Mutsuga Masato, Usui Akihiko

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   Vol. 68 ( 8 ) page: 768 - 773   2020.8

  78. Modified sutureless repair using left atrial appendage flap for acquired left-sided pulmonary vein stenosis

    Ito Hideki, Mutsuga Masato, Tokuda Yoshiyuki, Usui Akihiko

    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY   Vol. 58 ( 2 ) page: 395 - 397   2020.8

  79. The incidence and risk factors of hypofibrinogenemia in cardiovascular surgery

    Nishi Toshihiko, Mutsuga Masato, Akita Toshiaki, Narita Yuji, Fujimoto Kazuro, Tokuda Yoshiyuki, Terazawa Sachie, Ito Hideki, Nishiwaki Kimitoshi, Usui Akihiko

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   Vol. 68 ( 4 ) page: 335 - 341   2020.4

  80. 肺高血圧治療部門新規開設施設におけるCTEPHに対するPEA/BPA中期成績の検討

    寺澤 幸枝, 安藤 太三, 足立 史郎, 近藤 隆久, 石田 真一, 矢野 大介, 秋田 翔, 西 俊彦, 芦田 真一, 宗像 寿祥, 内田 亘, 松村 泰基, 伊藤 英樹, 徳田 順之, 六鹿 雅登, 藤本 和朗, 成田 裕司, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 50回   page: O11 - 3   2020.3

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  81. Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device

    Hiraiwa Hiroaki, Okumura Takahiro, Shimizu Shinya, Arao Yoshihito, Oishi Hideo, Kato Hiroo, Kuwayama Tasuku, Yamaguchi Shogo, Haga Tomoaki, Yokoi Tsuyoshi, Kondo Toru, Sugiura Yuki, Kano Naoaki, Watanabe Naoki, Fukaya Kenji, Furusawa Kenji, Sawamura Akinori, Morimoto Ryota, Fujimoto Kazuro, Mutsuga Masato, Usui Akihiko, Murohara Toyoaki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 1 ) page: 129 - 134   2020.2

  82. Spinal cord injury following aortic arch replacement

    Tokuda Yoshiyuki, Fujimoto Kazuro, Narita Yuji, Mutsuga Masato, Terazawa Sachie, Ito Hideki, Matsumura Yasumoto, Uchida Wataru, Munakata Hisaaki, Ashida Shinichi, Ono Tsukasa, Nishi Toshihiko, Yano Daisuke, Ishida Shinichi, Kuwabara Fumiaki, Akita Toshiaki, Usui Akihiko

    SURGERY TODAY   Vol. 50 ( 2 ) page: 106 - 113   2020.2

  83. A Floating Stitch on the Anterior Mitral Leaflet Can Eliminate Systolic Anterior Motion in Hypertrophic Obstructive Cardiomyopathy

    Mutsuga Masato, Narita Yuji, Usui Akihiko

    SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY   Vol. 32 ( 2 ) page: 266 - 268   2020

  84. Total resection of an infected aortic arch aneurysm caused by Mycobacterium avium: a case report

    Yagami Kei, Fujita Takashi, Ishida Shinichi, Mutsuga Masato

    JOURNAL OF CARDIOTHORACIC SURGERY   Vol. 14 ( 1 )   2019.8

  85. A functional evaluation of cerebral perfusion for coronary artery bypass grafting patients

    Teramoto Chikao, Mutsuga Masato, Kawaguchi Osamu, Araki Yoshimori, Matsuda Joe, Usui Akihiko

    HEART AND VESSELS   Vol. 34 ( 7 ) page: 1122 - 1131   2019.7

  86. Neurologic Deficit After Aortic Arch Replacement: The Influence of the Aortic Atherosclerosis

    Tokuda Yoshiyuki, Narita Yuji, Fujimoto Kazuro, Mutsuga Masato, Terazawa Sachie, Ito Hideki, Uchida Wataru, Usui Akihiko

    ANNALS OF THORACIC SURGERY   Vol. 108 ( 1 ) page: 107 - 114   2019.7

  87. The efficacy of immediate bridging thoracic endovascular aortic repair for ruptured infected thoracic aortic aneurysms

    Ito Hideki, Mutsuga Masato, Oshima Hideki, Usui Akihiko

    JOURNAL OF VASCULAR SURGERY CASES AND INNOVATIVE TECHNIQUES   Vol. 5 ( 2 ) page: 152 - 155   2019.6

  88. 術前の神経筋電気刺激療法を併用した理学療法が有効であった植込型補助人工心臓装着術症例

    服部 慶子, 小林 聖典, 羽賀 智明, 六鹿 雅登, 寺井 千晶, 高木 大地, 奥村 貴裕, 碓氷 章彦, 室原 豊明

    日本循環器学会学術集会抄録集   Vol. 83回   page: CP31 - 6   2019.3

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  89. Hemodynamics of cardiac tamponade during extracorporeal membrane oxygenation support in a patient with fulminant myocarditis Reviewed

    Toru Kondo, Ryota Morimoto, Tsuyoshi Yokoi, Shogo Yamaguchi, Tasuku Kuwayama, Tomoaki Haga, Hiroaki Hiraiwa, Yuki Sugiura, Naoki Watanabe, Naoaki Kano, Takeo Ichii, Kenji Fukaya, Akinori Sawamura, Takahiro Okumura, Tomo Yoshizumi, Masato Mutsuga, Kazuro Fujimoto, Naoyuki Matsuda, Akihiko Usui, Toyoaki Murohara

    Journal of Cardiology Cases   Vol. 19 ( 1 ) page: 22 - 24   2019.1

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    DOI: 10.1016/j.jccase.2018.08.009

    PubMed

  90. Usefulness of lymphography and computed tomography for detecting the site of chyle leakage

    Ito Hideki, Usui Akihiko, Uchida Wataru, Mutsuga Masato

    INDIAN JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY   Vol. 35 ( 1 ) page: 104 - 107   2019.1

  91. Stem Cell Therapy for Aortic Aneurysm: Does the Administered Cell Type Influence the Therapeutic Effects? Reviewed

    Yamawaki-Ogaka A, Fujimoto KL, Mutsuga M, Tokuda Y, Usui A, Narita Y

    J Regen Med.   Vol. 8 ( 1 )   2019

  92. Strategy of Cardiovascular Surgery for Patients With Dementia as Evaluated by Mini-Mental State Examination

    Terazawa Sachie, Oshima Hideki, Narita Yuji, Fujimoto Kazuro, Mutsuga Masato, Tokuda Yoshiyuki, Yoshizumi Tomo, Ito Hideki, Uchida Wataru, Usui Akihiko

    CIRCULATION JOURNAL   Vol. 82 ( 12 ) page: 2998 - 3004   2018.12

  93. The oral administration of clarithromycin prevents the progression and rupture of aortic aneurysm

    Uchida Wataru, Narita Yuji, Yamawaki-Ogata Aika, Tokuda Yoshiyuki, Mutsuga Masato, Fujimoto Kazuro Lee, Abe Tomonobu, Oshima Hideki, Usui Akihiko

    JOURNAL OF VASCULAR SURGERY   Vol. 68 ( 6 ) page: 82S - +   2018.12

  94. The Possibility of Clarithromycin for the Treatment of Type B Aortic Dissection.

    Uchida Wataru, Yamawaki-Ogata Aika, Hideki Ito, Sachie Tarazawa, Tokuda Yoshiyuki, Mutsuga Masato, Fujimoto Kazuro L., Yuji Narita, Usui Akihiko

    CIRCULATION   Vol. 138   2018.11

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  95. Aortic sarcoidosis complicated by a pulmonary artery aneurysm

    Uchida Wataru, Tokuda Yoshiyuki, Mutsuga Masato, Usui Akihiko

    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY   Vol. 54 ( 4 ) page: 786 - 788   2018.10

  96. Usefulness of lymphography and computed tomography for detecting the site of chyle leakage. Reviewed

    Hideki Ito, Akihiko Usui, Wataru Uchida, Masato Mutsuga

    Indian Journal of Thoracic and Cardiovascular Surgery volume   Vol. 35   page: 104 - 107   2018.9

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  97. Promising method for management of venoarterial extracorporeal membrane oxygenation: A case of severe heart failure successfully stabilized by “high-flow/vasodilation method” Reviewed

    Toru Kondo, Akinori Sawamura, Takahiro Okumura, Naoaki Kano, Ryota Morimoto, Naoki Watanabe, Hiroaki Hiraiwa, Tasuku Kuwayama, Yuki Sugiura, Tomoaki Haga, Shogo Yamaguchi, Kenji Fukaya, Tsuyoshi Yokoi, Kazuro Fujimoto, Masato Mutsuga, Tomo Yoshizumi, Naoyuki Matsuda, Akihiko Usui, Toyoaki Murohara

    Journal of Cardiology Cases   Vol. 18 ( 2 ) page: 81 - 84   2018.8

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    We report the case of a 58-year-old man with dilated cardiomyopathy who was hospitalized because of worsening heart failure. As his symptoms were refractory even with the administration of inotropes, he was given peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO) upon transfer to our hospital. On admission, serum creatinine was 2.62 mg/dL and total bilirubin 10.8 mg/dL. The cannulas inserted were 16-Fr for infusion and 21-Fr for drainage. When the blood flow was increased to 2.14 L/min/m2 to improve organ dysfunction, the aortic valve became continuously close with the mean arterial pressure of 85 mmHg. Therefore, we administrated vasodilators to decrease mean arterial pressure, or left ventricular afterload, which achieved opening aortic valve continuously. After the cannula sizes were scaled up to 18Fr for infusion and 24Fr for drainage to gain further blood flow, the aortic valve opened continuously and mean pulmonary pressure decreased. Our strategy to maintain adequate flow rate of VA-ECMO using vasodilator, “high-flow/vasodilation method”, achieved hemodynamic stability. Additionally, the concentration of serum creatinine and total bilirubin gradually decreased to within the normal range, although the patient succumbed 58 days after transfer to our hospital. &lt
    Learning objective: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is often used as a first-line mechanical circulatory support in patients with severe heart failure. However, its management is difficult and not established. We discuss the efficacy and potency of our “high-flow/vasodilation method” in the management of VA-ECMO.&gt

    DOI: 10.1016/j.jccase.2018.05.002

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    PubMed

  98. 破裂性感染性胸部大動脈瘤に対するBridging TEVARの有効性

    伊藤 英樹, 大島 英揮, 成田 裕司, 阿部 知伸, 藤本 和朗, 六鹿 雅登, 徳田 順之, 寺澤 幸枝, 吉住 朋

    日本血管外科学会雑誌   Vol. 27 ( Suppl. ) page: PR10 - 1   2018.6

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  99. 急性A型解離での脳保護 頸動脈Static Obstructionに対するAorto Carotid Bypassの試み

    阿部 知伸, 伊藤 英樹, 吉住 朋, 寺澤 幸枝, 徳田 順之, 藤本 和朗, 六鹿 雅登, 成田 裕司, 大島 英揮, 碓氷 章彦

    日本血管外科学会雑誌   Vol. 27 ( Suppl. ) page: SS(M)3 - 5   2018.6

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  100. 大血管浸潤癌に対する血管外科的治療戦略 上大静脈再建を要する上大静脈浸潤腫瘍に対する治療成績

    寺本 慎男, 秋田 利明, 大島 英揮, 成田 裕司, 阿部 知伸, 六鹿 雅登, 藤本 和朗, 徳田 順之, 寺澤 幸枝, 伊藤 英樹, 吉住 朋, 川口 晃司, 福井 高幸, 横井 香平, 碓氷 章彦

    日本血管外科学会雑誌   Vol. 27 ( Suppl. ) page: PD3 - 2   2018.6

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  101. Non-Bacterial Thrombotic Endocarditis Associated With Crohn's Disease.

    Uchida W, Mutsuga M, Ito H, Oshima H, Usui A

    The Annals of thoracic surgery   Vol. 105 ( 5 ) page: E199 - E201   2018.5

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    DOI: 10.1016/j.athoracsur.2017.12.005

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    PubMed

  102. 術中凝固障害の危険因子の検討 術中最低フィブリノーゲン値からの考察

    西 俊彦, 秋田 利明, 大島 英揮, 成田 裕司, 阿部 知伸, 六鹿 雅登, 藤本 和朗, 徳田 順之, 寺澤 幸枝, 吉住 朋

    日本集中治療医学会雑誌   Vol. 25 ( Suppl. ) page: [P32 - 8]   2018.2

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  103. 機械弁による弁置換後のAnticoagulation Related Hemorrhageの発生と年齢との関係

    阿部 知伸, 伊藤 英樹, 吉住 朋, 寺澤 幸枝, 徳田 順之, 藤本 和朗, 六鹿 雅登, 成田 裕司, 大島 英揮, 秋田 利明, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 48回   page: 786 - 786   2018.2

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  104. 自己弁温存手術時代のBio-Bentallの意義

    六鹿 雅登, 伊藤 英樹, 吉住 朋, 寺澤 幸枝, 徳田 順之, 藤本 和朗, 阿部 知伸, 成田 裕司, 大島 英輝, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 48回   page: 672 - 672   2018.2

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  105. 植込み型LVAD術後および心臓移植後の社会復帰への集学的チームアプローチ

    藤本 和朗, 碓氷 章彦, 大島 英揮, 成田 裕司, 阿部 知伸, 六鹿 雅登, 徳田 順之, 伊藤 英樹, 寺澤 幸恵

    日本心臓血管外科学会学術総会抄録集   Vol. 48回   page: 829 - 829   2018.2

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  106. 大伏在静脈Sequential AnastomosisでのParallel Anastomosisの応用

    阿部 知伸, 伊藤 英樹, 吉住 朋, 寺澤 幸枝, 徳田 順之, 藤本 和朗, 六鹿 雅登, 成田 裕司, 大島 英揮, 秋田 利明, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 48回   page: 821 - 821   2018.2

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  107. 大動脈性状が弓部置換の成績に与える影響

    徳田 順之, 伊藤 英樹, 吉住 朋, 寺澤 幸枝, 藤本 和朗, 六鹿 雅登, 阿部 知伸, 成田 裕司, 大島 英揮, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 48回   page: 110 - 110   2018.2

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  108. 大動脈手術後のSecondary graft-esophageal fistula7例の経験

    伊藤 英樹, 大島 英揮, 成田 裕司, 阿部 知伸, 藤本 和朗, 六鹿 雅登, 徳田 順之, 寺澤 幸枝, 吉住 朋

    日本心臓血管外科学会学術総会抄録集   Vol. 48回   page: 400 - 400   2018.2

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  109. 大動脈術後人工血管感染19例における検討

    伊藤 英樹, 大島 英揮, 成田 裕司, 阿部 知伸, 藤本 和朗, 六鹿 雅登, 徳田 順之, 寺澤 幸枝, 吉住 朋, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 48回   page: 921 - 921   2018.2

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  110. 大動脈解離術後に認めた膵虚血性変化

    大野 司, 大島 英揮, 成田 裕司, 阿部 知伸, 六鹿 雅登, 藤本 和朗, 徳田 順之, 寺澤 幸枝, 寺本 慎男, 吉住 朋, 伊藤 英樹, 増子 雄二, 内田 亘, 宗像 寿祥, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 48回   page: 104 - 104   2018.2

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  111. 弓部大動脈手術における脊髄障害に関する検討

    徳田 順之, 伊藤 英樹, 吉住 朋, 寺澤 幸枝, 藤本 和朗, 六鹿 雅登, 阿部 知伸, 成田 裕司, 大島 英揮, 秋田 利明, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 48回   page: 414 - 414   2018.2

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  112. 当院におけるRITA-LAD開存症例に対する再開心術の検討

    増子 雄二, 大島 英揮, 成田 裕司, 阿部 知伸, 六鹿 雅登, 藤本 和朗, 徳田 順之, 寺澤 幸枝, 吉住 朋, 伊藤 英樹, 寺本 慎男, 内田 亘, 宗像 寿祥, 大河 秀行, 大野 司, 西 俊彦, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 48回   page: 185 - 185   2018.2

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  113. 当院における僧帽弁形成術後僧帽弁再手術の検討

    内田 亘, 西 俊彦, 大野 司, 大河 秀行, 宗像 寿祥, 増子 雄二, 寺本 慎男, 伊藤 英樹, 吉住 朋, 寺澤 幸枝, 徳田 順之, 藤本 和朗, 六鹿 雅登, 阿部 知伸, 成田 裕司, 大島 英揮, 秋田 利明, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 48回   page: 811 - 811   2018.2

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  114. 心大血管手術におけるフレイル評価と周術期成績の検討

    寺澤 幸枝, 伊藤 英樹, 吉住 朋, 徳田 順之, 六鹿 雅登, 藤本 和朗, 阿部 知伸, 成田 裕司, 小林 聖典, 大島 英揮, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 48回   page: 289 - 289   2018.2

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  115. 急性大動脈解離術後、吻合部仮性瘤破裂に対する治療戦略

    六鹿 雅登, 伊藤 英樹, 吉住 朋, 寺澤 幸枝, 徳田 順之, 藤本 和朗, 阿部 知伸, 成田 裕司, 大島 英輝, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 48回   page: 987 - 987   2018.2

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  116. 人工弁周囲逆流に対する治療

    西 俊彦, 秋田 利明, 大島 英揮, 成田 裕司, 阿部 知伸, 六鹿 雅登, 藤本 和朗, 徳田 順之, 寺澤 幸枝, 吉住 朋, 伊藤 英樹, 寺本 慎男, 増子 雄二, 内田 亘, 宗像 寿祥, 大河 秀行, 大野 司, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 48回   page: 886 - 886   2018.2

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  117. LVOTO、SAMを有するMRに対するcine-CT/MRIを用いた正確な僧帽弁形成術

    大島 英揮, 成田 裕司, 阿部 知伸, 藤本 和朗, 六鹿 雅登, 徳田 順之, 寺澤 幸枝, 吉住 朋, 伊藤 英樹, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 48回   page: 67 - 67   2018.2

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  118. Sapien XTにて術中にopen stuckをきたした1例

    宗像 寿祥, 秋田 利明, 大島 英揮, 成田 裕司, 阿部 知伸, 六鹿 雅登, 藤本 和朗, 徳田 順之, 寺澤 幸枝, 碓氷 章彦

    日本集中治療医学会雑誌   Vol. 25 ( Suppl. ) page: [P42 - 7]   2018.2

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  119. Stent graft治療後に胸部大動脈open surgeryを要した17症例の検討

    吉住 朋, 伊藤 英樹, 寺澤 幸枝, 徳田 順之, 藤本 和朗, 六鹿 雅登, 阿部 知伸, 成田 裕司, 大島 英揮, 秋田 利明, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 48回   page: 673 - 673   2018.2

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  120. CABG手術時に合併する中等度MRに対する治療成績 冠動脈バイパス手術施行時に中等度機能性MRに対する介入を行うべきか

    宗像 寿祥, 大島 英揮, 成田 裕司, 阿部 知伸, 六鹿 雅登, 藤本 和朗, 徳田 順之, 寺澤 幸枝, 吉住 朋, 伊藤 英樹, 寺本 慎男, 増子 雄二, 内田 亘, 大河 秀行, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 48回   page: 430 - 430   2018.2

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  121. A型急性大動脈解離でのCentral RepairとAorto-Carotid Bypassの同時施行

    阿部 知伸, 伊藤 英樹, 吉住 朋, 寺澤 幸枝, 徳田 順之, 藤本 和朗, 六鹿 雅登, 成田 裕司, 大島 英揮, 秋田 利明, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 48回   page: 727 - 727   2018.2

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  122. [Future Aspects of Bio-Bentall Procedure].

    Mutsuga M, Usui A

    Kyobu geka. The Japanese journal of thoracic surgery   Vol. 71 ( 1 ) page: 37 - 42   2018.1

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  123. Hemorrhagic Pericardial Cyst Complicated with Constrictive Pericarditis

    Oguri Mitsutoshi, Ohguchi Shiou, Takahara Kunihiko, Kawamura Yoshihiro, Yokoi Yuki, Izumi Kazuhiro, Fujita Takashi, Yagami Kei, Mutsuga Masato

    INTERNAL MEDICINE   Vol. 57 ( 24 ) page: 3565 - 3568   2018

  124. Virtual angioscopy with multidetector computed tomography for the diagnosis of pannus formation in mechanical aortic valves

    Mutsuga Masato, Narita Yuji, Oshima Hideki, Usui Akihiko

    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY   Vol. 52 ( 6 ) page: 1233 - 1233   2017.12

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    DOI: 10.1093/ejcts/ezx234

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  125. Clinical outcomes and quality of life after surgery for dilated ascending aorta at the time of aortic valve replacement; wrapping versus graft replacement

    Abe Tomonobu, Terazawa Sachie, Ito Hideki, Tokuda Yoshiyuki, Fujimoto Kazuro, Mutsuga Masato, Narita Yuji, Oshima Hideki, Usui Akihiko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 79 ( 4 ) page: 443 - 451   2017.11

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    DOI: 10.18999/nagjms.79.4.443

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  126. ここまできた日本の補助人工心臓 DT時代に向けてのVAD治療の現状

    六鹿 雅登, 伊藤 英樹, 寺澤 幸枝, 徳田 順之, 藤本 和朗, 阿部 知伸, 成田 裕司, 大島 英輝, 碓氷 章彦

    日本臨床外科学会雑誌   Vol. 78 ( 増刊 ) page: 384 - 384   2017.10

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  127. 植込み型LVAD患者の社会復帰への課題 植込み型LVAD患者の社会復帰の重要性

    藤本 和朗, 碓氷 章彦, 大島 英揮, 成田 裕司, 阿部 知伸, 六鹿 雅登, 徳田 順之

    人工臓器   Vol. 46 ( 2 ) page: S - 32   2017.8

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  128. 当院におけるリズムコントロールデバイスの経静脈的リード抜去症例の検討 合併症ゼロを目指して

    成田 裕司, 西 俊彦, 大野 司, 大河 秀行, 宗像 寿祥, 内田 亘, 増子 雄二, 寺本 慎男, 伊藤 英樹, 寺澤 幸枝, 徳田 順之, 六鹿 雅登, 藤本 和朗, 阿部 知伸, 大島 英揮, 碓氷 章彦

    人工臓器   Vol. 46 ( 2 ) page: S - 105   2017.8

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  129. 心原性ショックに対するVAD治療 体外式拍動流型と遠心ポンプの使い分け 当院におけるINTERMACS profile 1-2に対する体外式VADの治療戦略

    六鹿 雅登, 伊藤 英樹, 寺澤 幸枝, 徳田 順之, 藤本 和朗, 阿部 知伸, 成田 裕司, 大島 英揮, 碓氷 章彦

    人工臓器   Vol. 46 ( 2 ) page: S - 35   2017.8

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  130. Entire Circumferential Reconstruction of the Right Atrium Surrounded by Angiosarcoma

    Hibino Makoto, Abe Tomonobu, Oshima Hideki, Narita Yuji, Mutsuga Masato, Fujimoto Kazuro L., Tokuda Yoshiyuki, Yamana Koji, Kuroda Taiyo, Usui Akihiko

    ANNALS OF THORACIC SURGERY   Vol. 103 ( 6 ) page: E483 - E485   2017.6

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    DOI: 10.1016/j.athoracsur.2016.11.032

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  131. 慢性B型大動脈解離に対する治療戦略

    六鹿 雅登, 伊藤 英樹, 山名 幸治, 寺澤 幸枝, 徳田 順之, 藤本 和郎, 阿部 知伸, 成田 裕司, 大島 英輝, 碓氷 章彦

    日本血管外科学会雑誌   Vol. 26 ( Suppl. ) page: O5 - 2   2017.6

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  132. [Total Arch Replacement Using Manufactured Frozen Elephant Trunk after Acute Type-A Dissection Repair].

    Hibino M, Mutsuga M, Oshima H, Narita Y, Abe T, Fujimoto K, Tokuda Y, Usui A

    Kyobu geka. The Japanese journal of thoracic surgery   Vol. 70 ( 4 ) page: 281-285   2017.4

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  133. The efficacy and risk of cerebrospinal fluid drainage for thoracoabdominal aortic aneurysm repair: a retrospective observational comparison between drainage and non-drainage

    Sugiura Junya, Oshima Hideki, Abe Tomonobu, Narita Yuji, Araki Yoshimori, Fujimoto Kazuro, Mutsuga Masato, Usui Akihiko

    INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY   Vol. 24 ( 4 ) page: 609 - 614   2017.4

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    DOI: 10.1093/icvts/ivw436

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  134. 胸腹部大動脈瘤に対する二期的TEVARを目的としたHybrid手術

    六鹿 雅登, 伊藤 英樹, 山名 幸治, 寺澤 幸枝, 徳田 順之, 藤本 和郎, 阿部 知伸, 成田 裕司, 大島 英輝, 碓氷 章彦

    日本外科学会定期学術集会抄録集   Vol. 117回   page: PS - 8   2017.4

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  135. 東海地区心臓移植実施施設の検討 名古屋大学の補助人工心臓治療の現状を踏まえて

    藤本 和朗, 六鹿 雅登, 成田 裕司, 阿部 知伸, 大島 英揮, 碓氷 章彦

    移植   Vol. 52 ( 1 ) page: 88 - 88   2017.4

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  136. 我が国の人工心臓治療の現況と展望 日本における重症心不全に対してVAD治療が主流となる時代の予測(Prediction of dominant VAD therapy era for severe heart failure in Japan)

    藤本 和朗, 碓氷 章彦, 大島 英揮, 成田 裕司, 阿部 知伸, 六鹿 雅登, 徳田 順之

    日本外科学会定期学術集会抄録集   Vol. 117回   page: SY - 2   2017.4

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  137. ビッグデータ時代の外科医療 JACVSD/NCDビッグデータの臨床応用への課題

    徳田 順之, 伊藤 英樹, 寺澤 幸枝, 山名 孝治, 六鹿 雅登, 藤本 和朗, 阿部 知伸, 成田 裕司, 大島 英揮, 碓氷 章彦

    日本外科学会定期学術集会抄録集   Vol. 117回   page: SY - 1   2017.4

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  138. 【胸部大動脈に対するステントグラフト治療up-to-date】Stanford A型大動脈解離術後の慢性解離性大動脈瘤に対する企業製frozen elephant trunkを用いた弓部置換術の手術成績

    日尾野 誠, 六鹿 雅登, 大島 英揮, 成田 裕司, 阿部 知伸, 藤本 和朗, 徳田 順之, 碓氷 章彦

    胸部外科   Vol. 70 ( 4 ) page: 281 - 285   2017.4

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    Stanford A型大動脈解離術後の慢性解離性大動脈瘤に対してJ Graft Open Stent Graft(JOSG)を使用して弓部置換術を施行した11例(男性6名、女性5名、平均66.2±8.0歳)を対象とした。全例独歩退院した。合併症は軽度感覚障害のみ遺残した不全対麻痺を1例に認めた。ほかの合併症としては創感染2例、間質性肺炎1例を認めた。術後平均2.1±1.9ヵ月時にCTで大動脈を評価し、JOSG末梢端は7例で大動脈弁、4例で肺門部に位置した。全例で術前に認めた弓部のエントリーは、術後には末梢側吻合部を含む胸部には認めず、残存する主要エントリーは全例で、術前のリエントリーである腹部大動脈以下に限局した。腹部分枝閉塞は認めなかった。中期遠隔(平均観察9.2ヵ月、最長14ヵ月)に死亡例は認めなかったが大動脈関連合併症は4例に認めた。下行大動脈の切迫破裂2例、下行大動脈の偽腔拡大1例、下行大動脈の再解離1例で、全3例に再手術を要した。早期、中期とも死亡例は認めなかった。

    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J00349&link_issn=&doc_id=20170406170010&doc_link_id=40021150487&url=http%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F40021150487&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

  139. LVAD装着周術期の上腕周囲径変化は骨格筋蛋白分解を反映する可能性がある

    小林 聖典, 六鹿 雅登, 奥村 貴裕, 清水 美帆, 山田 純生, 碓氷 章彦

    日本循環器学会学術集会抄録集   Vol. 81回   page: CA - 09   2017.3

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  140. 術前の握力低下は胸部大血管手術患者における長期人工呼吸器管理のリスク因子である

    清水 美帆, 山田 純生, 大島 英揮, 六鹿 雅登, 藤本 和朗, 成田 裕司, 阿部 知伸, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 47回   page: 686 - 686   2017.2

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  141. 胸部大動脈手術において脳保護法が高次脳機能に及ぼす影響の検討

    寺澤 幸枝, 林 和寛, 大野 司, 内田 亘, 増子 雄二, 寺本 慎男, 伊藤 英樹, 山名 孝治, 徳田 順之, 六鹿 雅登, 藤本 和朗, 成田 裕司, 阿部 知伸, 大島 英揮, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 47回   page: 270 - 270   2017.2

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  142. 虚血性僧帽弁閉鎖不全に対する僧帽弁輪形成と両尖温存弁置換術の長期成績の比較

    阿部 知伸, 伊藤 英樹, 山名 孝治, 寺澤 幸枝, 徳田 順之, 藤本 和朗, 六鹿 雅登, 成田 裕司, 大島 英揮, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 47回   page: 144 - 144   2017.2

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  143. 慢性B型解離の治療戦略

    六鹿 雅登, 伊藤 英樹, 山名 幸治, 寺澤 幸枝, 徳田 順之, 藤本 和郎, 阿部 知伸, 成田 裕司, 大島 英揮, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 47回   page: 234 - 234   2017.2

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  144. 人工心肺離脱困難症例に対する補助循環導入症例の検討

    増子 雄二, 大島 英揮, 成田 裕司, 阿部 知伸, 藤本 和朗, 六鹿 雅登, 徳田 順之, 寺澤 幸枝, 山名 孝治, 伊藤 英樹, 寺本 慎男, 内田 亘, 大野 司, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 47回   page: 789 - 789   2017.2

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  145. 僧帽弁手術における、左房内腔からの僧帽弁輪直接エコーによる冠状動脈回旋枝の描出

    阿部 知伸, 内田 亘, 伊藤 英樹, 山名 孝治, 寺澤 幸枝, 徳田 順之, 藤本 和郎, 六鹿 雅登, 成田 裕司, 大島 英揮, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 47回   page: 568 - 568   2017.2

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  146. 僧帽弁手術時に三尖弁に介入しなかった症例の予後

    伊藤 英樹, 大島 英揮, 成田 裕司, 阿部 知伸, 藤本 和朗, 六鹿 雅登, 徳田 順之, 寺澤 幸枝, 山名 孝治, 寺本 慎男, 増子 雄二, 内田 亘, 大野 司, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 47回   page: 524 - 524   2017.2

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  147. 冠動脈バイパス術のグラフト選択、術式選択(on-or off-pump) 透析、糖尿病、肥満、高齢患者での選択と理由 70歳以上高齢者におけるONCABとOPCABの比較 早期および遠隔成績

    大島 英揮, 成田 裕司, 阿部 知伸, 藤本 和朗, 六鹿 雅登, 徳田 順之, 寺澤 幸枝, 山名 孝治, 伊藤 英樹, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 47回   page: 730 - 730   2017.2

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  148. 冠動脈瘤を合併した冠動脈瘻に対する外科手術

    増子 雄二, 大島 英揮, 成田 裕司, 阿部 知伸, 藤本 和朗, 六鹿 雅登, 徳田 順之, 寺澤 幸枝, 山名 孝治, 伊藤 英樹, 寺本 慎男, 内田 亘, 大野 司, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 47回   page: 334 - 334   2017.2

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  149. 広範囲弓部大動脈瘤に対するType III hybrid arch repairの遠隔成績

    徳田 順之, 六鹿 雅登, 藤本 和朗, 阿部 知伸, 成田 裕司, 大島 英揮, 古森 公浩, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 47回   page: 237 - 237   2017.2

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  150. 心臓血管肉腫に対する、広範両心房・上大静脈切除と、右房左房別個再建

    阿部 知伸, 成田 裕司, 日尾野 誠, 大野 司, 内田 亘, 増子 雄二, 寺本 慎男, 伊藤 英樹, 山名 孝治, 寺澤 幸枝, 徳田 順之, 藤本 和朗, 六鹿 雅登, 大島 英揮, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 47回   page: 493 - 493   2017.2

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  151. 上行置換術後の再手術弓部全置換術におけるtrifurcate graft使用の有用性

    山名 孝治, 大島 英揮, 大野 司, 内田 亘, 増子 雄二, 伊藤 英樹, 寺本 慎男, 寺澤 幸枝, 徳田 順之, 藤本 和朗, 六鹿 雅登, 阿部 知伸, 成田 裕司, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 47回   page: 58 - 58   2017.2

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  152. Modified double patch法によるpost-infarction VSP修復術

    大島 英揮, 成田 裕司, 阿部 知伸, 藤本 和朗, 六鹿 雅登, 徳田 順之

    日本心臓血管外科学会学術総会抄録集   Vol. 47回   page: 45 - 45   2017.2

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  153. unprotected LMTに対するPCI及びCABGによる血行再建の治療成績

    寺本 慎男, 碓氷 章彦, 大島 英輝, 成田 祐司, 阿部 知伸, 藤本 和朗, 六鹿 雅登, 徳田 順之, 寺澤 幸枝, 山名 孝治, 伊藤 英樹, 増子 雄二, 内田 亘, 大野 司

    日本心臓血管外科学会学術総会抄録集   Vol. 47回   page: 175 - 175   2017.2

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  154. Clarithromycinの大動脈瘤発生抑制効果の作用機序の解明

    内田 亘, 成田 裕司, 緒方 藍歌, 伊藤 英樹, 山名 孝治, 寺澤 幸枝, 徳田 順之, 六鹿 雅登, 藤本 和朗, 阿部 知伸, 大島 英揮, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 47回   page: 850 - 850   2017.2

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  155. Early and Late Outcomes of Thoracic Aortic Surgery in Hemodialysis Patients (vol 102, pg 1282, 2016)

    M. Hibino, H. Oshima, Y. Narita, T. Abe, M. Mutsuga, K. L. Fujimoto, Y. Tokuda, S. Terazawa, H. Ito, A. Usui

    ANNALS OF THORACIC SURGERY   Vol. 103 ( 1 ) page: 366 - 366   2017.1

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  156. The changes of aortic diameter after aortic repair with aortic tailoring technique for chronic type B aortic dissection Reviewed

    Hiroto Suenaga, Akihiko Usui, Masato Mutsuga, Hideki Oshima, Tomonobu Abe, Yuji Narita, Kazuro Fujimoto, Yoshiyuki Tokuda

    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY   Vol. 50 ( 6 ) page: 1118 - 1123   2016.12

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    OBJECTIVES: Aortic repair with aortic tailoring of the false lumen can preserve the true lumen and intercostal arteries naturally. It is a useful surgical strategy to prevent paraplegia. However, aortic remodelling of tailored segments in a late phase after surgery is another concern. This study investigates the destiny of aortic remodelling of tailored aorta.
    METHODS: From June 2004 to April 2013, 21 consecutive patients underwent aortic tailoring operation for chronic type B aortic dissecting aneurysm. The mean age at operation was 60 +/- 10 years (range, 43-77). The tailored aortic segments were followed by serial CT scanning with the mean follow-up period of 46 +/- 32 months (range, 2-103).
    RESULTS: There were no operative deaths but paraplegia in 1, stroke in 1 and reversible renal failure in 2 patients. There were two late deaths: one due to pneumonia and the other due to aneurysmal rupture of the abdominal aorta. Eighteen patients revealed a completely thrombosed false lumen and no expansion of the tailored aorta, with it remaining less than 40 mm in diameter during follow-up. However, 3 cases were associated with a patent false lumen and 2 cases revealed aortic events. The aortic event-free rate at 5 years was 95 +/- 5.1% in all patients and 66 +/- 27% in patients in the patent false lumen group.
    CONCLUSIONS: Aortic tailoring is a useful surgical technique for chronic type B aortic dissection. Paraplegia and ischaemia of other visceral organs could less likely occur. Patients with a completely thrombosed false lumen revealed no aortic events; however, a patent false lumen was associated with a high risk of aortic events.

    DOI: 10.1093/ejcts/ezw240

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    PubMed

  157. The long-term results and changing patterns of biological valves at the mitral position in contemporary practice in Japan

    Abe Tomonobu, Ito Hideki, Mutsuga Masato, Fujimoto Kazuro, Terazawa Sachie, Narita Yuji, Oshima Hideki, Usui Akihiko

    Nagoya Journal of Medical Science   Vol. 78 ( 4 ) page: 369 - 376   2016.11

  158. Early and Late Outcomes of Thoracic Aortic Surgery in Hemodialysis Patients Reviewed

    Makoto Hibino, Hideki Oshima, Yuji Narita, Tomonobu Abe, Masato Mutsuga, Kazuro L. Fujimoto, Yoshiyuki Tokuda, Sachie Terazawa, Hideki Ito, Akihiko Usui

    ANNALS OF THORACIC SURGERY   Vol. 102 ( 4 ) page: 1282 - 1288   2016.10

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    Background. The number of cardiovascular surgeries among hemodialysis patients is increasing according to the growing population of hemodialysis patients; however, the clinical outcome has not yet been clarified, especially in thoracic aortic surgery. The purpose of this study was to assess the early and late outcomes of thoracic aortic surgery in hemodialysis patients.
    Methods. We retrospectively analyzed the outcomes of 700 consecutive open thoracic aortic surgeries from 2002 to 2014. We identified 21 patients receiving preoperative hemodialysis (group HD) and 679 patients not receiving preoperative hemodialysis (group N). The patients were predominantly male, had diabetes mellitus and cardiogenic shock, and had less hyperlipidemia and elective surgery in group HD. The early and late outcomes were compared between 21 patients in each group using a propensity-score matched analysis.
    Results. The hospital stay and intensive care unit stay were significantly longer in group HD even after matching. The 30-day mortality and inhospital mortality showed no significant differences, whereas the rate of postoperative pneumonia was significantly higher in group HD compared with the matched group N (p=0.0067). The 1-year, 3-year, and 7-year survival rates in group HD were 73.4%, 45.7%, and 30.5%, respectively, which were significantly poorer than that of group N both in the prematched (p &lt; 0.001) and matched analyses (p=0.0027).
    Conclusions. Considering the various operative risks associated with hemodialysis patients, the early mortality rate is acceptable, even after the association with many respiratory complications. Although hemodialysis patients have a compromised prognosis after surgery, excessive hesitation to perform thoracic aortic surgery may be avoided. (C) 2016 by The Society of Thoracic Surgeons

    DOI: 10.1016/j.athoracsur.2016.03.073

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    PubMed

  159. 植込み型補助人工心臓装着患者の在宅管理 長期植心移植待機時代の植え込み型補助人工心臓装着患者の在宅管理

    藤本 和朗, 碓氷 章彦, 大島 英揮, 成田 裕司, 阿部 知伸, 六鹿 雅登

    人工臓器   Vol. 45 ( 2 ) page: S - 58   2016.10

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  160. 中・長期成績からみた透析患者に対する人工弁選択 機械弁・生体弁による透析患者の弁置換後の長期予後 マイクロシミュレーション

    阿部 知伸, 岡田 典隆, 田嶋 一喜, 寺澤 幸枝, 徳田 順之, 藤本 和朗, 六鹿 雅登, 成田 裕司, 大島 英揮, 碓氷 章彦

    人工臓器   Vol. 45 ( 2 ) page: S - 71   2016.10

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  161. Extended total arch replacement via the L-incision approach: single-stage repair for extensive aneurysms of the aortic arch Reviewed

    Yoshiyuki Tokuda, Hideki Oshima, Yuji Narita, Tomonobu Abe, Masato Mutsuga, Kazuro Fujimoto, Sachie Terazawa, Hideki Ito, Makoto Hibino, Wataru Uchida, Kimihiro Komori, Akihiko Usui

    INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY   Vol. 22 ( 6 ) page: 750 - 755   2016.6

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    OBJECTIVES: Total arch replacement via the L-incision approach (a combination of left anterior thoracotomy and upper median sternotomy) can be used to achieve more extensive replacement.
    METHODS: In the period between 2002 and 2014, 279 total arch replacement procedures were performed. After excluding cases of acute aortic dissection and cases involving concomitant, hybrid or frozen elephant trunk procedures, patients who underwent isolated total arch replacement via an L-incision (n = 29) and via median sternotomy (n = 143) were identified and the data pertaining to their cases were analysed.
    RESULTS: Operative mortality was higher in the L-incision group than in the median sternotomy group (6.9 vs 2.1%); however, the difference was not statistically significant. The L-incision group displayed a higher rate of respiratory complications, including pneumonia (28 vs 7.0%, P = 0.0034), the need for tracheostomy (17 vs 2.1%, P = 0.0038) and pulmonary haemorrhage (6.9 vs 0%, P = 0.028). The rate of paraplegia was similar between the groups (0 vs 1.4%, P = 1.00), despite the wider range replaced via the L-incision approach (7.3 +/- 1.5 vs 4.7 +/- 0.8 anatomical zones, P &lt; 0.001). The rates of other complications and functional recovery were similar. The long-term survival (73 vs 84% at 5 years) and aortic event-free rates (94 vs 96% at 5 years) were similar in both groups.
    CONCLUSIONS: A combination of left anterior thoracotomy and upper median sternotomy can be applied to the single-stage repair of extended aneurysms with acceptable results in appropriately selected patients.

    DOI: 10.1093/icvts/ivw034

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    PubMed

  162. A型解離術後の慢性解離性大動脈瘤に対する弓部大動脈置換術

    日尾野 誠, 碓氷 章彦, 伊藤 英樹, 寺澤 幸枝, 徳田 順之, 藤本 和朗, 六鹿 雅登, 阿部 知伸, 成田 裕司, 大島 英揮

    日本血管外科学会雑誌   Vol. 25 ( Suppl. ) page: 322 - 322   2016.6

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  163. [Aortic Valve Replacement of Quadricuspid Valve with Regurgitation].

    Yagami K, Oshima H, Narita Y, Abe T, Araki Y, Fujimoto K, Mutsuga M, Terazawa S, Ito H, Kuwabara F, Usui A

    Kyobu geka. The Japanese journal of thoracic surgery   Vol. 69 ( 4 ) page: 321 - 4   2016.4

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  164. 臨床経験 閉鎖不全を呈した大動脈四尖弁に対する弁置換術

    八神 啓, 大島 英揮, 成田 裕司, 阿部 知伸, 荒木 善盛, 藤本 和朗, 六鹿 雅登, 寺澤 幸枝, 伊藤 英樹, 桑原 史明, 碓氷 章彦

    胸部外科   Vol. 69 ( 4 ) page: 321 - 324   2016.4

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    症例は60〜72歳の男性3例、女性1例であった。いずれも呼吸苦を主訴とした大動脈弁閉鎖不全症による心不全症状で、前医から著者らの施設へ紹介となった。術前の冠状動脈造影では全例、異常はみられなかった。1例は術前経胸壁エコーによる術前診断が可能であったが、3例は術中にはじめて大動脈四尖弁と診断された。Hurwitz分類ではtype aが1例、type bが2例、type cが1例であった。4症例とも人工弁による大動脈弁置換術が施行された。その結果、病理所見では全例で切除弁尖に粘液腫様の変性を認めた。術後経過も合併症なく経過良好で、独歩退院となった。

    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2016&ichushi_jid=J00349&link_issn=&doc_id=20160405010019&doc_link_id=40020777450&url=http%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F40020777450&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

  165. 脳合併症を伴う活動期感染性心内膜炎に対する治療戦略

    寺澤 幸枝, 伊藤 英樹, 六鹿 雅登, 藤本 和朗, 阿部 知伸, 成田 裕司, 大島 英揮, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 46回   page: OP5 - 4   2016.2

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  166. 活動性感染性心内膜炎に対する外科的介入の治療戦略

    藤本 和朗, 碓氷 章彦, 大島 英揮, 阿部 知伸, 成田 裕司, 六鹿 雅登, 寺澤 幸枝, 伊藤 英樹

    日本心臓血管外科学会学術総会抄録集   Vol. 46回   page: PP - 057   2016.2

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  167. 胸腹部大動脈瘤Open Surgeryにおける左腎動脈の先行再建

    阿部 知伸, 大島 英揮, 成田 裕司, 六鹿 雅登, 藤本 和朗, 寺澤 幸枝, 杉浦 純也, 伊藤 英樹, 日比野 誠, 小坂井 基史, 小西 康信, 内田 亘, 末永 啓人, 大野 司, 碓永 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 46回   page: VP10 - 2   2016.2

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  168. 心臓外科医が母になること 如何にbalanceを保ちゆくか

    寺澤 幸枝, 伊藤 英樹, 徳田 順之, 藤本 和朗, 六鹿 雅登, 阿部 知伸, 成田 裕司, 大島 英揮, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 46回   page: SP6 - 1   2016.2

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  169. 低左心機能、慢性大動脈弁閉鎖不全症に対する大動脈弁置換術の長期成績

    末永 啓人, 碓氷 章彦, 大島 英揮, 成田 裕司, 阿部 知伸, 六鹿 雅登, 藤本 和朗, 寺澤 幸枝, 伊藤 英樹, 小坂井 基史, 内田 亘, 日尾野 誠, 大野 司, 小西 康信, 黒田 太陽

    日本心臓血管外科学会学術総会抄録集   Vol. 46回   page: OP20 - 2   2016.2

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  170. 大動脈弁位機械弁生体弁の長期予後 単施設540例20余年のフォローアップ

    阿部 知伸, 大島 英揮, 成田 裕司, 六鹿 雅登, 藤本 和朗, 寺澤 幸枝, 杉浦 純也, 伊藤 英樹, 日比野 誠, 小坂井 基史, 小西 康信, 内田 亘, 黒田 太陽, 藤田 山, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 46回   page: OP3 - 4   2016.2

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  171. 大動脈瘤に対する幹細胞療法 効果のメカニズムに関して

    成田 裕司, 緒方 藍歌, 小坂井 基史, 藤本 和朗, 六鹿 雅登, 阿部 知伸, 大島 英揮, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 46回   page: OP10 - 2   2016.2

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  172. 弓部大動脈瘤の治療戦略 A型解離術後の慢性解離性大動脈瘤に対するJOSGを用いた弓部置換術

    日尾野 誠, 碓氷 章彦, 伊藤 英樹, 寺澤 幸枝, 藤本 和朗, 六鹿 雅登, 阿部 知伸, 成田 裕司, 大島 英揮

    日本心臓血管外科学会学術総会抄録集   Vol. 46回   page: PR7 - 2   2016.2

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  173. 当院における弁膜症再手術の初期および遠隔成績

    伊藤 英樹, 大島 英揮, 成田 裕司, 阿部 知伸, 六鹿 雅登, 藤本 和朗, 寺澤 幸枝, 杉浦 純也, 内田 亘, 小坂井 基司, 日尾野 誠, 小西 康信, 大野 司, 末永 啓人, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 46回   page: PP - 192   2016.2

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  174. ハイリスク・高齢者の大動脈弁狭窄症に対する弁置換術 費用対効果からの検討

    大島 英揮, 成田 裕司, 阿部 知伸, 六鹿 雅登, 藤本 和朗, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 46回   page: PP - 041   2016.2

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  175. HD患者の弁種選択 機械弁か生体弁か? 一般患者の人工弁選択基準を血液透析患者にあてはめることは妥当か? モデル解析

    阿部 知伸, 岡田 典隆, 大島 英揮, 成田 裕司, 六鹿 雅登, 藤本 和朗, 寺澤 幸枝, 杉浦 純也, 伊藤 英樹, 日比野 誠, 小坂井 基史, 小西 康信, 内田 亘, 田嶋 一喜, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 46回   page: PD4 - 7   2016.2

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  176. Type III hybrid arch repairによる広範大動脈瘤の治療 L字切開広範弓部置換との比較

    徳田 順之, 伊藤 英樹, 寺澤 幸枝, 藤本 和朗, 六鹿 雅登, 阿部 知伸, 成田 裕司, 大島 英揮, 古森 公浩, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 46回   page: PP - 245   2016.2

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  177. CABG術後再手術におけるliving graftと心筋保護 to cramp or not to cramp

    黒田 太陽, 大島 英揮, 成田 裕司, 阿部 知伸, 六鹿 雅登, 藤本 和朗, 寺澤 幸枝, 杉浦 純也, 伊藤 英樹, 小坂井 基史, 日尾野 誠, 内田 亘, 小西 康信, 大野 司, 末永 啓人, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 46回   page: PR2 - 3   2016.2

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  178. 65歳以上の患者に対する大動脈弁温存時代のBio-Bentallの意義

    六鹿 雅登, 伊藤 英樹, 杉浦 純也, 寺澤 幸枝, 藤本 和朗, 阿部 知伸, 成田 裕司, 大島 英輝, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 46回   page: PP - 172   2016.2

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  179. 80歳以上の高齢者の大動脈弁狭窄症に対する大動脈弁置換術の手術成績

    藤田 山, 伊藤 英樹, 杉浦 純也, 寺澤 幸枝, 藤本 和朗, 六鹿 雅登, 成田 裕司, 阿部 知伸, 大島 英揮, 碓氷 章彦

    日本心臓血管外科学会学術総会抄録集   Vol. 46回   page: OP3 - 2   2016.2

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  180. Hybrid versus open repair of aortic arch aneurysms: comparison of postoperative and mid-term outcomes with a propensity score-matching analysis Reviewed

    Yoshiyuki Tokuda, Hideki Oshima, Yuji Narita, Tomonobu Abe, Yoshimori Araki, Masato Mutsuga, Kazuro Fujimoto, Sachie Terazawa, Kei Yagami, Hideki Ito, Kiyoto Yamamoto, Kimihiro Komori, Akihiko Usui

    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY   Vol. 49 ( 1 ) page: 149 - 156   2016.1

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    OBJECTIVES: Operative strategies for repairing aortic arch aneurysms should be re-evaluated following recent technical advances.
    METHODS: Of 364 patients who underwent aortic arch repair between 2002 and 2014, 58 were high-risk subjects who received isolated hybrid arch repair (HAR) via median sternotomy (type I n = 32, type II n = 1 and type III n = 25). During this period, excluding patients with type A dissection or extensive aneurysms, 124 patients received isolated open arch repair via median sternotomy. The patients in the HAR and open arch repair groups were compared. A propensity score-matching analysis was applied to adjust for baseline risk factors.
    RESULTS: The patients in the HAR group were older (77 years +/- 6 vs 69 +/- 9, P &lt; 0.0001), exhibited a greater rate of malignancy (21 vs 4.8%, P = 0.0022) and had higher logistic EuroSCORE values (31 +/- 18 vs 20 +/- 15, P &lt; 0.0001) than those in the open arch repair group. Following propensity score matching creating 38 matched pairs, the differences in preoperative risk diminished. Operative complications, including the mortality rate (2.6 vs 0%), were similar between the groups. Apart from the lower rates of cardiopulmonary bypass (CPB) and circulatory arrest, there was no apparent superiority of HAR with respect to patient recovery. The mean follow-up duration was 52.5 months, during which the rate of freedom from aortic events in the HAR and open arch repair groups was 79 and 99% at 24 months, respectively (P &lt; 0.0001).
    CONCLUSIONS: HAR achieves equivalent short-term results to standard open arch repair, with a decreased need for CPB. However, considering the inferior mid-term outcomes of this procedure, its indications should be limited to high-risk patients.

    DOI: 10.1093/ejcts/ezv063

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    PubMed

  181. 慢性解離性大動脈瘤の術後トラネキサム酸投与の有用性

    日尾野 誠, 碓氷 章彦, 伊藤 英樹, 寺澤 幸枝, 藤本 和郎, 六鹿 雅登, 成田 祐司, 阿部 知伸, 大島 英揮

    日本集中治療医学会雑誌   Vol. 23 ( Suppl. ) page: 792 - 792   2016.1

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  182. An Epicardial Mesothelial Cyst Attached to the Ascending Aorta Reviewed

    Yoshihito Suenaga, Tomonobu Abe, Masato Mutsuga, Yoshimori Araki, Akihiko Usui

    HEART SURGERY FORUM   Vol. 18 ( 5 ) page: E194 - E195   2015.10

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    An epicardial mesothelial cyst, which can be defined as a mesothelial cyst attached to the epicardium surrounding the heart and the great vessels inside the pericardial sac, is a rare condition. We herein report a case of epicardial cyst, which was attached to the ascending aorta. The patient was a 76-year-old male who underwent coronary artery bypass surgery, and the cyst was found incidentally. It was approximately 5 cm in diameter, and histological examination confirmed mesothelial cell origin. The ascending aorta has not previously been reported as the origin of an epicardial mesothelial cyst. This case gives new insight into the embryology of these cysts.

    DOI: 10.1532/hsf.1293

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  183. 人工弁の遠隔成績からみた選択 メタアナリシスから見た本邦の機械弁置換術後長期成績の特徴とそれが人工弁選択に与える影響

    阿部 知伸, 伊藤 英樹, 杉浦 純也, 寺澤 幸枝, 六鹿 雅登, 藤本 和朗, 荒木 善盛, 成田 裕司, 大島 英揮, 碓氷 章彦

    人工臓器   Vol. 44 ( 2 ) page: S - 59   2015.10

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  184. Destination Therapyに向けての植込み型補助人工心臓の展望と問題点

    六鹿 雅登, 藤本 和朗, 伊藤 英樹, 杉浦 純也, 阿部 知伸, 成田 裕司, 大島 英揮, 碓氷 章彦

    人工臓器   Vol. 44 ( 2 ) page: S - 153   2015.10

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  185. The number of cardiovascular surgeries in Japan may decrease after 2020

    Usui Akihiko, Abe Tomonobu, Araki Yoshimori, Narita Yuji, Mutsuga Masato, Oshima Hideki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 77 ( 3 ) page: 389 - 398   2015.8

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  186. Impact of Surgical Stroke on the Early and Late Outcomes After Thoracic Aortic Operations Reviewed

    Noritaka Okada, Hideki Oshima, Yuji Narita, Tomonobu Abe, Yoshimori Araki, Masato Mutsuga, Kazuro L. Fujimoto, Yoshiyuki Tokuda, Akihiko Usui

    ANNALS OF THORACIC SURGERY   Vol. 99 ( 6 ) page: 2017 - 2023   2015.6

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    Background. Thoracic aortic operations still remain associated with substantial risks of death and neurologic injury. This study investigated the impact of surgical stroke on the early and late outcomes, focusing on the physical status and quality of life (QOL).
    Methods. From 1986 to 2008, 500 patients (aged 63 +/- 13 years) underwent open thoracic aortic repair for root and ascending (31%), arch (39%), extended arch (10%), and descending and thoracoabdominal (19%) aneurysms. Brain protection consisted of retrograde cerebral perfusion (52%), antegrade cerebral perfusion (29%), and simple deep hypothermic circulatory arrest (19%). Surgical stroke was defined as a neurologic deficit persisting more than 72 hours after the operation. QOL was assessed with the Short-Form 36 Health Survey Questionnaire 5.9 +/- 4.2 years after the operation.
    Results. Stroke occurred in 10.3% of patients. Hospital mortality was 21% in the stroke group and 2.7% in the nonstroke group (p &lt; 0.001). At hospital discharge, 76% of survivors in the stroke group had permanent neurologic deficits (PNDs), with sustained tracheostomy in 39%, tube feeding in 46%, and gastrostomy in 14%, and 89% required transfer to other facilities. PND was an independent risk factor for late death (hazard ratio, 2.29; 95% confidence interval, 1.04 to 4.62; p = 0.041) in a multivariate analysis. The physical component of the QOL score was worse in the PND group (51% vs 100%; p = 0.039), whereas the mental component was similar in both groups (14% vs 14%).
    Conclusions. Surgical stroke is associated with high hospital mortality and PNDs that decrease late survival and the physical component score of the QOL survey. (C) 2015 by The Society of Thoracic Surgeons

    DOI: 10.1016/j.athoracsur.2015.01.033

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  187. Influence of the characteristics of Japanese patients on the long-term outcomes after aortic valve replacement: results of a microsimulation Reviewed

    Tomonobu Abe, Hideki Oshima, Yuji Narita, Yoshimori Araki, Masato Mutsuga, Kazuro Fujimoto, Yoshiyuki Tokuda, Sachie Terazawa, Kei Yagami, Akihiko Usui

    General Thoracic and Cardiovascular Surgery   Vol. 63 ( 5 ) page: 260 - 266   2015.5

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    DOI: 10.1007/s11748-014-0499-2

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    Other Link: http://link.springer.com/article/10.1007/s11748-014-0499-2/fulltext.html

  188. Open stentの適応と問題点 広範囲弓部瘤に対するFrozen Elephant Trunk;FET法の適応と問題点

    六鹿 雅登, 伊藤 英樹, 阿部 知伸, 大島 英輝, 碓氷 章彦

    日本血管外科学会雑誌   Vol. 24 ( 3 ) page: 302 - 302   2015.5

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  189. An L-Shaped Incision for an Extensive Thoracic Aortic Aneurysm and Coronary Artery Bypass Using the Left Internal Thoracic Artery. Reviewed

    Abe T, Suenaga H, Oshima H, Araki Y, Mutsuga M, Fujimoto K, Usui A

    Aorta (Stamford, Conn.)   Vol. 3 ( 2 ) page: 86 - 9   2015.4

  190. 心臓血管 B型解離性大動脈瘤の治療戦略

    荒木 善盛, 碓永 章彦, 大島 英揮, 阿部 知伸, 成田 裕司, 六鹿 雅登, 藤本 和朗, 寺澤 幸枝, 八神 啓, 伊藤 英樹, 藤井 恵

    日本外科学会定期学術集会抄録集   Vol. 115回   page: OP - 5   2015.4

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  191. 大動脈弁狭窄ハイリスク症例に対する治療 その適応と成績 心臓血管 ハイリスク高齢者大動脈弁狭窄症に対するTAVRの適応 risk-SCOREと医療費からの検討

    大島 英揮, 成田 裕司, 阿部 知伸, 荒木 善盛, 藤本 和朗, 六鹿 雅登, 寺澤 幸枝, 八神 啓, 伊藤 英樹, 碓氷 章彦

    日本外科学会定期学術集会抄録集   Vol. 115回   page: PD - 1   2015.4

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  192. IMPACT OF THE INTRAOPERATIVE USE OF FIBRINOGEN CONCENTRATE FOR HYPOFIBRINOGENEMIA DURING THORACIC AORTIC SURGERY Reviewed

    Yoshimori Araki, Akihiko Usui, Hideki Oshima, Tomonobu Abe, Kazuro Fujimoto, Masato Mutsuga, Yoshiyuki Tokuda, Sachie Terazawa, Kei Yagami, Hideki Ito

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 77 ( 1-2 ) page: 265 - 273   2015.2

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    Thoracic aortic surgery often causes massive bleeding due to coagulopathy. Hypofibrinogenemia is one of the major causative factors, but the utility of the intraoperative administration of fibrinogen concentrate has not yet been proven. The aim of this study was to estimate incidence of hypofibrinogenemia and to evaluate efficacy of using fibrinogen concentrate intraoperatively. The perioperative serum fibrinogen levels (SFL) had routinely been measured in consecutive 216 thoracic aortic surgeries performed from 2010 to 2012. Fibrinogen concentrate was principally used for hypofibrinogenemia (&lt; 150 mg/dl of SFL) at cardiopulmonary bypass (CPB) termination. The patients who received fibrinogen concentrate (FIB group) were compared with the patients who did not received (non Fib group). There were 147 patients (68%) in FIB group at a dose of 5.5 +/- 3.5 g. The SFL were dramatically decreased with values of 164 +/- 71 mg/dl at CPB termination, compared to the preoperative SFL of 352 +/- 131 mg/dl. In the FIB group, the intraoperative and postoperative SFLs were 139 +/- 53 and 262 +/- 75 (mg/dl), respectively. Thus the SFL was recovered quickly by the administration. 110 cases (51%) showed hypofibrinogenemia at the termination of CPB. The predictors of hypofibrinogenemia were preoperative SFL &lt; 250 mg/dl, emergency surgery and thracoabdominal aortic surgery. Hypofibrinogenemia frequently was observed at the termination of CPB during thoracic aortic surgery. Administering intraoperative fibrinogen concentrate appears to be a useful option to treat coagulopathy.

    Web of Science

  193. 胸部大血管手術におけるフィブリノゲン製剤使用の実際

    荒木 善盛, 伊藤 英樹, 八神 啓, 寺澤 幸枝, 徳田 順之, 六鹿 雅登, 藤本 和朗, 阿部 知伸, 大島 英揮, 碓氷 章彦

    日本心臓血管外科学会雑誌   Vol. 44 ( Suppl. ) page: 342 - 342   2015.1

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  194. 胸部大動脈再手術症例の現況とその手術戦略

    六鹿 雅登, 伊藤 英樹, 八神 啓, 寺澤 幸枝, 徳田 順行, 藤本 和朗, 荒木 善盛, 阿部 知伸, 成田 裕司, 大島 英輝, 碓氷 章彦

    日本心臓血管外科学会雑誌   Vol. 44 ( Suppl. ) page: 436 - 436   2015.1

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  195. 心臓移植実施施設の必要性の検討 拡大か縮小か?地域の重症心不全治療からの考察

    藤本 和朗, 碓氷 章彦, 大島 英輝, 成田 裕司, 阿部 知伸, 荒木 善盛, 六鹿 雅登, 徳田 順之, 寺澤 幸枝

    日本心臓血管外科学会雑誌   Vol. 44 ( Suppl. ) page: 508 - 508   2015.1

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  196. 冠動脈疾患を合併する胸部大動脈手術症例の検討

    伊藤 英樹, 大島 英揮, 成田 裕司, 阿部 知伸, 荒木 善盛, 六鹿 雅登, 藤本 和朗, 徳田 順之, 寺澤 幸枝, 八神 啓, 蒔苗 永, 藤井 恵, 大野 司, 末永 啓人

    日本心臓血管外科学会雑誌   Vol. 44 ( Suppl. ) page: 437 - 437   2015.1

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  197. 多発瘤形成を伴うCervical Aortic Archに対する外科的治療例

    伊藤 英樹, 大島 英揮, 成田 裕司, 阿部 知伸, 荒木 善盛, 六鹿 雅登, 藤本 和朗, 徳田 順之, 寺澤 幸枝, 八神 啓, 蒔苗 永, 藤井 恵, 大野 司, 末永 啓人

    日本心臓血管外科学会雑誌   Vol. 44 ( Suppl. ) page: 497 - 497   2015.1

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  198. 大動脈弁治療の現在と未来 術式と人工弁の選択 本邦の大動脈置換術後の弁関連合併症の特徴と、それが人工弁選択に与える影響

    阿部 知伸, 大島 英揮, 成田 裕司, 荒木 善盛, 六鹿 雅登, 藤本 和郎, 徳田 順之, 寺澤 幸枝, 八神 啓, 伊藤 英樹, 碓氷 章彦

    日本心臓血管外科学会雑誌   Vol. 44 ( Suppl. ) page: 149 - 149   2015.1

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  199. 当院における胸部人工血管感染に対する再血行再建術の術後成績

    大野 司, 大島 英揮, 成田 裕司, 阿部 知伸, 荒木 善盛, 六鹿 雅登, 藤本 和朗, 徳田 順之, 寺澤 幸枝, 八神 啓, 伊藤 英樹, 蒔苗 永, 藤井 恵, 末永 啓人, 碓氷 章彦

    日本心臓血管外科学会雑誌   Vol. 44 ( Suppl. ) page: 497 - 497   2015.1

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  200. 三尖弁輪形成術 遠隔期にmoderate以上の逆流が残存する危険因子の検討

    伊藤 英樹, 大島 英揮, 成田 裕司, 阿部 知伸, 荒木 善盛, 六鹿 雅登, 藤本 和朗, 徳田 順之, 寺澤 幸枝, 八神 啓, 蒔苗 永, 藤井 恵, 大野 司, 末永 啓人

    日本心臓血管外科学会雑誌   Vol. 44 ( Suppl. ) page: 234 - 234   2015.1

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  201. Debranching TEVARの合併症対策と手技上の工夫

    徳田 順之, 末永 啓人, 藤井 恵, 伊藤 英樹, 八神 啓, 寺澤 幸枝, 藤本 和朗, 六鹿 雅登, 荒木 善盛, 成田 裕司, 阿部 知伸, 大島 英揮, 山本 清人, 古森 公浩, 碓氷 章彦

    日本心臓血管外科学会雑誌   Vol. 44 ( Suppl. ) page: 326 - 326   2015.1

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  202. Entire shaggy aortaの治療方針

    八神 啓, 碓氷 章彦, 大島 英揮, 成田 裕司, 阿部 知伸, 荒木 善盛, 藤本 和朗, 六鹿 雅登, 徳田 順之, 寺澤 幸枝, 蒔苗 永, 伊藤 英樹, 大野 司, 末永 啓人

    日本心臓血管外科学会雑誌   Vol. 44 ( Suppl. ) page: 322 - 322   2015.1

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  203. TEVAR後ステントグラフト抜去を伴う開胸大動脈手術を要した症例の検討

    寺澤 幸枝, 大島 英揮, 末永 啓人, 大野 司, 藤井 恵, 蒔苗 永, 伊藤 英樹, 八神 啓, 徳田 順之, 藤本 和朗, 六鹿 雅登, 荒木 善盛, 成田 裕司, 阿部 知伸, 碓氷 章彦

    日本心臓血管外科学会雑誌   Vol. 44 ( Suppl. ) page: 324 - 324   2015.1

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  204. ガイドライン施行後の冠血行再建術 2011年ガイドライン施行後にみられる外科的冠血行再建術における変化

    大島 英揮, 成田 裕司, 阿部 知伸, 荒木 善盛, 六鹿 雅登, 藤本 和朗, 徳田 順之, 碓氷 章彦

    日本心臓血管外科学会雑誌   Vol. 44 ( Suppl. ) page: 173 - 173   2015.1

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  205. 植え込み型人工心臓(HeartMate II)患者管理の集学的向上への試み

    藤本 和朗, 六鹿 雅登, 大島 英輝, 成田 裕司, 阿部 知伸, 荒木 善盛, 徳田 順之, 碓氷 章彦

    人工臓器   Vol. 43 ( 2 ) page: S - 214   2014.9

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  206. 人工臓器感染に対する治療戦略 ペースメーカー等(Cardiovascular Implantable Electrical Devices)感染に対する治療戦略

    成田 裕司, 末永 啓人, 大野 司, 松村 泰基, 藤井 恵, 蒔苗 永, 伊藤 英樹, 八神 啓, 寺澤 幸枝, 徳田 順之, 六鹿 雅登, 藤本 和朗, 荒木 善盛, 阿部 知伸, 大島 英揮, 碓氷 章彦

    人工臓器   Vol. 43 ( 2 ) page: S - 64   2014.9

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  207. 心臓血管外科領域の難治感染症に対するFDG-PET/CTの応用

    徳田 順之, 大島 英揮, 阿部 知伸, 成田 裕司, 荒木 善盛, 藤本 和朗, 六鹿 雅登, 岡田 正穂, 寺澤 幸枝, 蒔苗 永, 八神 啓, 大野 司, 末永 啓人, 碓氷 章彦

    日本外科学会雑誌   Vol. 115 ( 臨増2 ) page: 486 - 486   2014.3

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  208. 心臓再手術のPitfalls 胸部大動脈再手術症例の検討

    碓氷 章彦, 成田 裕司, 阿部 知伸, 荒木 善盛, 藤本 和朗, 六鹿 雅登, 徳田 順之, 寺澤 幸枝, 大島 英揮

    日本外科学会雑誌   Vol. 115 ( 臨増2 ) page: 172 - 172   2014.3

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  209. 胸腹部慢性解離性大動脈瘤に対する計画的二期的手術例の検討

    八神 啓, 大島 英揮, 成田 裕司, 阿部 知伸, 荒木 善盛, 藤本 和朗, 六鹿 雅登, 徳田 順之, 岡田 正穂, 寺澤 幸枝, 蒔苗 永, 森脇 博夫, 大野 司, 末永 啓人

    日本心臓血管外科学会雑誌   Vol. 43 ( Suppl. ) page: 352 - 352   2014.1

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  210. 機械弁の植込み時年齢が高いと出血性合併症の発生率も高い メタ回帰による解析

    阿部 知伸, 大島 英揮, 荒木 善盛, 成田 裕司, 藤本 和朗, 六鹿 雅登, 徳田 順之, 岡田 正穂, 寺澤 幸枝, 碓氷 章彦

    日本心臓血管外科学会雑誌   Vol. 43 ( Suppl. ) page: 277 - 277   2014.1

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  211. 本邦の大動脈弁位生体弁の至適年齢は? micro simulationと再手術死亡率による感度分析

    阿部 知伸, 大島 英揮, 荒木 善盛, 成田 裕司, 藤本 和郎, 六鹿 雅登, 徳田 順之, 岡田 正穂, 寺澤 幸枝, 碓氷 章彦

    日本心臓血管外科学会雑誌   Vol. 43 ( Suppl. ) page: 278 - 278   2014.1

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  212. 同一アプローチによる胸部大動脈再手術症例の検討

    末永 啓人, 碓氷 章彦, 大島 英揮, 成田 裕司, 阿部 知伸, 荒木 善盛, 藤本 和朗, 六鹿 雅登, 岡田 正穂, 徳田 順之, 寺澤 幸枝, 蒔苗 永, 八神 啓, 大野 司

    日本心臓血管外科学会雑誌   Vol. 43 ( Suppl. ) page: 465 - 465   2014.1

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  213. 当院における大動脈基部再建術の長期予後および遠隔期QOL

    六鹿 雅登, 寺澤 幸枝, 岡田 正穂, 徳田 順行, 藤本 和朗, 成田 裕司, 荒木 善盛, 阿部 知伸, 大島 英輝, 碓氷 章彦

    日本心臓血管外科学会雑誌   Vol. 43 ( Suppl. ) page: 287 - 287   2014.1

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  214. 感染性弓部大動脈瘤破裂に対するbridging TEVAR

    大島 英揮, 成田 裕司, 阿部 知伸, 荒木 善盛, 藤本 和朗, 六鹿 雅登, 岡田 正穂, 徳田 順之, 末永 啓人, 碓氷 章彦

    日本心臓血管外科学会雑誌   Vol. 43 ( Suppl. ) page: 305 - 305   2014.1

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  215. Maze術後カテーテルアブレーションを要した症例の検討

    成田 裕司, 末永 啓人, 大野 司, 八神 啓, 蒔苗 永, 寺澤 幸枝, 徳田 順之, 岡田 正穂, 六鹿 雅登, 藤本 和朗, 荒木 善盛, 阿部 知伸, 大島 英揮, 碓氷 章彦

    日本心臓血管外科学会雑誌   Vol. 43 ( Suppl. ) page: 366 - 366   2014.1

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  216. Double sewing ring法を用いた改変型生物学的Bentall手術(Modified Biological-Bentall procedure with the double sewing ring technique)

    六鹿 雅登, 寺澤 幸枝, 岡田 正穂, 徳田 順行, 藤本 和朗, 荒木 善盛, 成田 裕司, 阿部 知伸, 大島 英輝, 碓氷 章彦

    日本心臓血管外科学会雑誌   Vol. 43 ( Suppl. ) page: 559 - 559   2014.1

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  217. A comparative study of two types of sternal pins used for sternal closure: poly-L-lactide sternal pins versus uncalcined hydroxyapatite poly-L-lactide sternal pins Reviewed

    Xian-ming Fu, Hideki Oshima, Yoshimori Araki, Yuji Narita, Masato Mutsuga, Noritaka Okada, Tomohiro Tsunekawa, Akihiko Usui

    JOURNAL OF ARTIFICIAL ORGANS   Vol. 16 ( 4 ) page: 458 - 463   2013.12

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    Bioabsorbable poly-l-lactide (PLLA) sternal pins are applied to reinforce sternal closure during cardiac surgery. However, these pins lack osteoconductivity. A new bioabsorbable sternal pin with osteoconductivity, made of uncalcined hydroxyapatite and poly-l-lactide (u-HA-PLLA) has been developed. This study was conducted to compare the two types of sternal pins in terms of sternal stability and healing after median sternotomy. Between October 2006 and January 2012, 105 patients underwent aortic surgery for aortic aneurysms or dissection via median sternotomy and sternal closure with sternal pins. Among these patients, 75 were followed for 12 months using serial computed tomography (CT). PLLA sternal pins were used in 30 patients (group A) and u-HA-PLLA sternal pins were used in 45 patients (group B). The incidence rates of transverse sternal dehiscence, anteroposterior displacement and complete sternal fusion were evaluated using CT. The cross-sectional cortical bone density area (CBDA) of the sternum around the sternal pins was examined to evaluate the osteoconductivity of the sternal pins. There were no significant differences between groups A and B in the sternal dehiscence rate (6.7 vs 4.4 %), sternal displacement rate (6.7 vs 2.2 %) or 12-month sternal fusion rate (63.3 vs 73.3 %). The CBDA around the sternal pins significantly increased between discharge and 12 months after surgery in group B (P &lt; 0.001) but not in group A. These results show that u-HA-PLLA sternal pins exhibit certain osteoconductivity; however, both PLLA and u-HA-PLLA sternal pins provide comparable clinical outcomes regarding sternal stability and healing.

    DOI: 10.1007/s10047-013-0727-z

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  218. [Surgical strategy for extended aortic arch aneurysm].

    Araki Y, Mutsuga M, Tokuda Y, Okada M, Abe T, Oshima H, Usui A

    Kyobu geka. The Japanese journal of thoracic surgery   Vol. 66 ( 11 ) page: 960 - 4   2013.10

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  219. 【弓部大動脈瘤-こだわりの術式と遠隔期成績】広範囲弓部大動脈瘤に対する外科治療の変遷

    荒木 善盛, 六鹿 雅登, 徳田 順之, 岡田 正穂, 阿部 知伸, 大島 英揮, 碓氷 章彦

    胸部外科   Vol. 66 ( 11 ) page: 960 - 964   2013.10

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    広範囲弓部瘤に対するL字開胸法(L群)、frozen elephant trunk法(F群)、long elephant trunk法(E群)、debranched TEVAR法(D群)を比較検討した。非解離性大動脈で待機手術を行った241例を対象とした。L群28例、F群30例、E群21例、D群10例であった。胸骨正中切開で行った弓部置換術152例(K群)を対照とした。術後合併症としては、L群では脳梗塞合併率が25.0%と高く、F群では脊髄障害の発生率が23.3%と高かった。E群は脊髄障害の発生はなかったが脳梗塞は19%で、D群では脳梗塞を40%と高率に認めた。呼吸不全はL群、E群で高率であった。入院死亡率はL群0%、F群6.7%、E群4.8%、D群20%、K群0.7%であった。

    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2013&ichushi_jid=J00349&link_issn=&doc_id=20130926210006&doc_link_id=40019809964&url=http%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F40019809964&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

  220. 当院における生体弁機能不全手術症例の検討

    岡田 正穂, 末永 啓人, 大野 司, 岡田 典隆, 蒔苗 永, 寺澤 幸枝, 徳田 順之, 六鹿 雅登, 藤本 和朗, 荒木 善盛, 成田 裕司, 阿部 知伸, 大島 英揮, 碓氷 章彦

    人工臓器   Vol. 42 ( 2 ) page: S - 226   2013.9

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  221. 劇症型心筋炎に対するBIVAD治療 Cannulation techniqueによる簡易BIVAD

    六鹿 雅登, 寺澤 幸枝, 岡田 正穂, 徳田 順行, 藤本 和朗, 荒木 善盛, 阿部 知伸, 成田 裕司, 大島 英輝, 碓氷 章彦

    人工臓器   Vol. 42 ( 2 ) page: S - 211   2013.9

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  222. 弁膜症手術症例のQOLとペースメーカ

    蒔苗 永, 荒木 善盛, 大島 英揮, 成田 裕司, 阿部 知伸, 六鹿 雅登, 碓氷 章彦

    人工臓器   Vol. 42 ( 2 ) page: S - 225   2013.9

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  223. 当院におけるデバイス感染に伴うリード抜去症例の検討

    成田 裕司, 末永 啓人, 大野 司, 岡田 典隆, 蒔苗 永, 寺澤 幸枝, 徳田 順之, 岡田 正穂, 六鹿 雅登, 藤本 和朗, 荒木 善盛, 阿部 知伸, 大島 英揮, 碓氷 章彦

    人工臓器   Vol. 42 ( 2 ) page: S - 225   2013.9

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  224. Detection of thoracic aortic prosthetic graft infection with 18F-fluorodeoxyglucose positron emission tomography/computed tomography Reviewed

    Yoshiyuki Tokuda, Hideki Oshima, Yoshimori Araki, Yuji Narita, Masato Mutsuga, Katsuhiko Kato, Akihiko Usui

    European Journal of Cardio-thoracic Surgery   Vol. 43 ( 6 ) page: 1183 - 1187   2013.6

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    OBJECTIVES: To investigate the diagnostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in detecting thoracic aortic prosthetic graft infection. METHODS: Nine patients with clinically suspected thoracic aortic graft infection underwent FDG-PET/CT scanning. In these patients, the diagnoses could not be confirmed using conventional modalities. The patients' clinical courses were retrospectively reviewed. RESULTS: On the basis of surgical, microbiological and clinical follow-up findings, the aortic grafts were considered infected in 4 patients and not infected in 5. All 4 patients with graft infection (root: 2 cases, arch: 1 case and descending: 1 case) eventually underwent in situ re-replacement. Two of the 4 patients also had abdominal grafts
    however, only the thoracic grafts were replaced because uptake was low around the abdominal grafts. The maximal standardized uptake value (SUVmax) in the perigraft area was higher in the infected group than in the non-infected group (11.4 ± 4.5 vs 6.9 ± 6.4), although the difference was not statistically significant. According to the receiver operating characteristic analysis, SUVmax &gt
    8 appeared to be the cut-off value in distinguishing the two groups (sensitivity: 1.0 and specificity: 0.8). CONCLUSIONS: FDG-PET/CT is useful for confirming the presence of graft infection by detecting high uptake around grafts and excluding other causes of inflammation. An SUVmax value greater than 8 around a graft suggests the presence of graft infection. In addition, FDG-PET/CT can be used to clarify the precise extent of infection. This is especially useful if multiple separated prosthetic grafts have been implanted. © The Author 2013. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

    DOI: 10.1093/ejcts/ezs693

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  225. [Recurrence of cardiac myxoma in the left atrial after 28 years; report of a case].

    Takanohashi A, Usui A, Mutsuga M, Tokuda Y, Araki Y, Narita Y, Oshima H, Ueda Y

    Kyobu geka. The Japanese journal of thoracic surgery   Vol. 65 ( 12 ) page: 1089 - 92   2012.11

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  226. Fast-track extubation after modified Fontan procedure Reviewed

    Masato Mutsuga, Luis G. Quinonez, Andrew S. Mackie, Colleen M. Norris, B. Elaine Marchak, Jennifer M. Rutledge, Ivan M. Rebeyka, David B. Ross

    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY   Vol. 144 ( 3 ) page: 547 - 52   2012.9

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    Objective: In 2007, we introduced a policy to plan to extubate all patients after a modified Fontan procedure in the operating room. Our objective was to review the feasibility, safety, and clinical outcomes of this approach.
    Methods: Patients who underwent a modified Fontan operation between May 2004 and May 2010 were reviewed.
    Results: Ninety-seven patients underwent a modified Fontan operation (mean age, 3.9 +/- 2.2 years; mean weight, 15.1 +/- 5.0 kg); 46 patients (47%) were extubated in the operating room (group A). Nineteen patients were extubated in the intensive care unit within 24 hours (group B), and 32 patients had delayed extubation (group C). The 3 groups were not significantly different with respect to preoperative characteristics. Twenty-four hours postoperatively, group A had a lower mean central venous pressure compared with patients in group B or C (13 vs 14 vs 17 mm Hg, respectively, P &lt;. 001); a higher base excess (0.4 vs -1.3 vs -3.4, P &lt;. 001); a lower fluid balance (234 vs 514 vs 730 mL, P &lt;. 001); and a lower inotrope score (4.6 vs 6.7 vs 10.8, P &lt;. 001). Group C had a longer median intensive care unit length of stay (2 vs 3 vs 6 nights, P = .01), kept their chest tubes longer (8 vs 9 vs 15 days, P = .001), and had a longer median hospital length of stay (9 vs 11 vs 21 days, P = .001).
    Conclusions: Extubation in the operating room after a modified Fontan procedure seems feasible. This approach is associated with improved early postoperative hemodynamics, earlier time to chest tube removal, and shorter intensive care unit and hospital lengths of stay. (J Thorac Cardiovasc Surg 2012; 144:547-52)

    DOI: 10.1016/j.jtcvs.2012.05.047

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  227. The Clinical Outcomes of Prolonged Donor Ischemic Time in Adult Patients Undergoing Heart Transplantation. A Single Center Experiences in Canada

    Mutsuga M., Wang S., MacArthur R., Mullen J., Modry D., Ross D., Meyer S.

    JOURNAL OF HEART AND LUNG TRANSPLANTATION   Vol. 31 ( 4 ) page: S93 - S94   2012.4

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  228. Spinal cord protection during a thoracoabdominal aortic repair for a chronic type B aortic dissection using the aortic tailoring strategy Reviewed

    Masato Mutsuga, Yuji Narita, Yoshimori Araki, Atsuo Maekawa, Hideki Oshima, Akihiko Usui, Yuichi Ueda

    INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY   Vol. 11 ( 1 ) page: 15 - 18   2010.7

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    Publishing type:Research paper (scientific journal)   Publisher:OXFORD UNIV PRESS  

    This study evaluated the clinical advantage of a novel technique to reconstruct a true lumen with aortic wall tailoring for aortic repair (aortic tailoring) or the reimplantation of intercostal arteries (vascular tube) in a chronic type B aortic dissection. Thirty-three consecutive extended thoracoabdominal aortic repairs have been performed for chronic type B dissection since 2000. The novel strategy was applied in 17 cases since 2004 including eight cases of aortic repair (group A) and nine cases of a vascular tube (group B). The other 16 cases were graft interposition in five and no reimplantation in 11 for group C. There were no surgical deaths in either group A or B, and only one late death in group C. No patients sustained transient or permanent paraplegia in group A and B, while three cases of paraplegia occurred in group C (18.8%). All of the intercostal arteries were well preserved in group A and an average of 9.8 intercostal arteries for nine patients were reimplantated in group B. The present technique can optimally preserve the intercostal arteries maximally and showed an excellent surgical mortality and morbidity, especially with regard to the protection of the spinal cord. (C) 2010 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.

    DOI: 10.1510/icvts.2009.223099

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  229. Effects of Extracellular Matrix on Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells into Smooth Muscle Cell Lineage: Utility for Cardiovascular Tissue Engineering Reviewed

    Shuichi Suzuki, Yuji Narita, Aika Yamawaki, Yosuke Murase, Makoto Satake, Masato Mutsuga, Hideki Okamoto, Hideaki Kagami, Minoru Ueda, Yuichi Ueda

    CELLS TISSUES ORGANS   Vol. 191 ( 4 ) page: 269 - 280   2010

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    Publishing type:Research paper (scientific journal)   Publisher:KARGER  

    Background: Bone marrow-derived mesenchymal stem cells (MSCs) can differentiate into various types of cell, and the extracellular matrix (ECM) is acknowledged to be important for the regulation of cell functions. In this study, we demonstrated the effects of ECMs on the differentiation of human bone marrow-derived MSCs into a smooth muscle cell (SMC) lineage. Methods: Human MSCs (hMSCs) were cultured on dishes coated with 3 types of ECM including laminin (LM), collagen type IV (Col-IV) and fibronectin for 7 days, and simultaneously cultured on a noncoated dish as a control. Cell numbers of these cultured hMSCs were counted, and their expression of SMC-specific genes and proteins was evaluated. hMSCs were then seeded on LM-coated biodegradable sheets and implanted into rat subcutaneous space. After 2 weeks of implantation, these tissues were evaluated. Results: The number of hMSCs was significantly increased by culture on Col-IV-coated dishes. The expression of SMC-specific genes and proteins (alpha-smooth muscle actin, ASMA; h1-calponin, CALP) in hMSC was significantly upregulated from culture on LM-coated dishes. LM-coated sheets showed
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    a significantly increased expression of ASMA and CALP protein in vivo. Moreover, a fully differentiated marker (SM2) was expressed in the in vivo implanted hMSCs in the course of 2 weeks on the LM-coated sheet. Conclusion: These results suggest that the signal transduction of the cell-matrix interaction for the differentiation of hMSCs into SMCs was activated when cultured with LM. LM-coated materials may thus be useful for cardiovascular tissue engineering. Copyright (C) 2009 S. Karger AG, Basel

    DOI: 10.1159/000260061

    Web of Science

    PubMed

  230. Institutional report - Congenital development of novel drug-eluting biodegradable nano-fiber for prevention of postoperative pulmonary venous obstruction Reviewed

    Masato Mutsuga, Yuji Narita, Aika Yamawaki, Makoto Satake, Hiroaki Kaneko, Akihiko Usui, Yuichi Ueda

    Interactive Cardiovascular and Thoracic Surgery   Vol. 8 ( 4 ) page: 402 - 6; discussion 406   2009.4

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    Pulmonary venous obstruction (PVO) after correction of total anomalous pulmonary venous connection (TAPVC) frequently occurs due to intimal-hyperplasia and the required re-operation. We have developed a novel sustained-release drug delivery system, using Tacrolimuseluting biodegradable nano-fiber (TEBN). It consists of nano-scale fiber composed of biodegradable polymer and Tacrolimus. This study evaluated the effects of TEBN for prevention of venous anastomotic stricture in a rat model to apply to PVO operation. Tacrolimus was incorporated into poly (L-lactide-co-glycolide). The venous stricture model was made by rat inferior vena cava anastomosis. The IVC anastomosis was covered with TEBN with 1.0 wt% Tacrolimus (n=12) or without TEBN as a control (n=12), and evaluated histologically at 1, 2, and 4 weeks after operation. The ratio of intimal area was significantly reduced in the TEBN group compared with the control group (ratio
    1 week: 0.43 ± 0.26 vs. 0.07 ± 0.04, P=0.04, 2 weeks: 0.39 ± 0.19 vs. 0.05 ± 0.02, P=0.01, 4 weeks: 0.31±0.15 vs. 0.09 ± 0.04, P=0.03, control vs. TEBN, respectively). Histological findings showed endothelialization along the inner surface of the vein even in TEBN. The TEBN reduced intimal hyperplasia and preserved endothelialization even in a venous stricture. These results suggested that this strategy might be useful for prevention of recurrent PVO after TAPVC correction. © 2009 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.

    DOI: 10.1510/icvts.2008.192831

    Scopus

    PubMed

  231. A new strategy for prevention of anastomotic stricture using tacrolimus-eluting biodegradable nanofiber Reviewed

    Masato Mutsuga, Yuji Narita, Aika Yamawaki, Makoto Satake, Hiroaki Kaneko, Yoshihiro Suematsu, Akihiko Usui, Yuichi Ueda

    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY   Vol. 137 ( 3 ) page: 703 - 709   2009.3

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    Publishing type:Research paper (scientific journal)   Publisher:MOSBY-ELSEVIER  

    Objective: We developed a novel sustained drug-eluting device using tacrolimus-eluting biodegradable nanofiber to prevent anastomotic stricture and evaluated the effects in a rat abdominal aortic anastomosis model.
    Methods: In vitro and in vivo tacrolimus release tests for tacrolimus-eluting biodegradable nanofiber were performed to confirm its sustained release. To verify the prevention of anastomotic stricture, tacrolimus-eluting biodegradable nanofiber was placed around the end-to-end anastomosis of abdominal aorta in rats. Five rats were allocated to the following 5 groups: ( 1) control without tacrolimus-eluting biodegradable nanofiber, ( 2) 5 mg of nanofiber only ( 0 wt% of tacrolimus), ( 3) 5 mg of tacrolimus-eluting biodegradable nanofiber containing 0.04 wt% of tacrolimus, ( 4) 5 mg of tacrolimus-eluting biodegradable nanofiber containing 0.1 wt% of tacrolimus, and ( 5) 5 mg of tacrolimus-eluting biodegradable nanofiber containing 1.0 wt% of tacrolimus. Morphometric and histologic analyses including immunohistochemistry were performed in each of the groups 2 weeks after the operation.
    Results: The tacrolimus-eluting biodegradable nanofiber gradually released tacrolimus for at least 1 month in vitro and in vivo. The ratio of intimal area was significantly reduced in the 1.0 wt% tacrolimus-eluting biodegradable nanofiber group compared with the other groups (0.26, 0.24, 0.25, 0.21, and 0.08 in control, 0 wt%, 0.04 wt%, 0.1 wt%, and 1.0 wt%, respectively, P &lt;. 05). The cells, which constitute intimal hyperplasia, were positive for smooth muscle actin and SMemb, and factor VIII revealed that endothelial cells covered the surface of the aortic lumen even in the 1.0 wt% tacrolimus-eluting biodegradable nanofiber group in immunohistochemistry.
    Conclusion: Tacrolimus-eluting biodegradable nanofiber reduced neointimal hyperplasia and preserved endothelialization. This device may be useful in the prevention of anastomotic stricture.

    DOI: 10.1016/j.jtcvs.2008.11.017

    Web of Science

    PubMed

  232. Acute occlusion of left coronary ostium associated with congenital quadricuspid aortic valve Reviewed

    M Mutsuga, S Tamaki, Y Yokoyama, N Kato, J Yokote, N Ohata

    ANNALS OF THORACIC SURGERY   Vol. 79 ( 5 ) page: 1760 - 1   2005.5

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    Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    A 10-year-old girl suffered from chest discomfort during exercise. She experienced an acute myocardial infarction accompanied by an obstruction in an orifice to the left coronary artery. An emergency operation revealed that the aortic valve was quadricuspid, and a left-sided small cusp had adhered to the aortic wall resulting in an unusual sac with a tiny slit. Resection of the sac disclosed the ostium to left coronary artery. Blood toward the left coronary artery passed through the tiny slit. The mechanisms of obstruction in the coronary artery were uncertain. She recovered well after the aortic valve replacement with resection of the aortic cusps. (c) 2005 by The Society of Thoracic Surgeons.

    DOI: 10.1016/j.athoracsur.2003.11.052

    Web of Science

    PubMed

  233. Pseudoaneurysm from the Mitral-Aortic Intervalvular Fibrosa Following Endocarditis Reviewed

    Yukifusa Yokoyama, Shuji Tamaki, Noriyuki Kato, Jun Yokote, Masato Mutsuga

    Japanese Journal of Thoracic and Cardiovascular Surgery   Vol. 51 ( 8 ) page: 374 - 7   2003.8

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    Publishing type:Research paper (international conference proceedings)   Publisher:Japanese Association for Thoracic Surgery  

    A rare case of a pseudoaneurysm from the mitral-aortic intervalvular fibrosa following bacterial endocarditis in a 17-year-old male is presented. Destructive infection secondarily involved the mitral-aortic intervalvular fibrosa. Perforation of this portion resulted in the formation of the pseudoaneurysm situated at the base of the left ventricle between the aorta and the left atrium. With echocardiography, computed topography, angiography, and magnetic resonance imaging (MRI), a pseudoaneurysm was diagnosed. MRI especially revealed detailed information and the extension of pseudoaneurysm. Our patient underwent resection of the pseudoaneurysm, reconstruction of left ventricular outflow with glutaraldehyde-preserved bovine pericardium, and replacement of the aortic valve. His postoperative course was uneventful. No recurrence of endocarditis was detected in the following year.

    DOI: 10.1007/BF02719470

    Scopus

    PubMed

  234. 新生児・乳児の人工心肺に対する血液浄化法の工夫 充填血液に対するSingle Pass HDF及び持続的HDFの効果

    小山 富生, 玉木 修治, 横山 幸房, 加藤 紀之, 横手 淳, 六鹿 雅登

    The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY   Vol. 50 ( Suppl. ) page: 283 - 283   2002.9

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  235. PCPS長期補助例における血液浄化の有用性

    横山 幸房, 玉木 修治, 伊藤 正夫, 加藤 紀之, 横手 淳, 六鹿 雅登, 岡田 正穂, 小山 富生, 山田 哲也, 片山 浩司

    ICUとCCU   Vol. 25 ( 12 ) page: 974 - 975   2001.12

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    Language:Japanese   Publisher:医学図書出版(株)  

  236. Right atrial myxoma associated with atrial septal defect: a case report and review of the literature Reviewed

    H Murayama, S Tamaki, N Kato, N Yuji, J Yokote, M Mutsuga, M Okada

    Ann Thorac Cardiovasc Surg   Vol. 7 ( 3 ) page: 166 - 169   2001.6

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  237. Repair of intercostal arteries in thoracoabdominal aneurysm Reviewed

    Y. Yokoyama, S. Tamaki, M. Ito, N. Kato, J. Yokote, M. Mutsuga, M. Okada

    Asian Cardiovascular and Thoracic Annals   Vol. 9 ( 3 ) page: 221 - 222   2001

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    A parallel aortic graft composed of a 20-mm graft with two 10-mm accessory grafts was used in the repair of a large thoracoabdominal aneurysm in a 50-year-old man. The graft was attached to 6 intercostal arteries and used immediately for spinal cord perfusion before repairing the aneurysm. The patient recovered quickly without paraplegia.

    DOI: 10.1177/021849230100900315

    Scopus

  238. 体外循環におけるbronchial returnの左室ベント流量に及ぼす影響

    成田 裕司, 玉木 修治, 横山 幸房, 加藤 紀之, 横手 淳, 六鹿 雅登, 岡田 雅穂, 小山 富生, 山田 哲也, 片山 浩司

    人工臓器   Vol. 29 ( 3 ) page: S - 99   2000.8

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  239. 大動脈弁位手術における左室vent流量測定の意義 逆流評価方法として

    成田 裕司, 玉木 修治, 横山 幸房, 加藤 紀之, 横手 淳, 六鹿 雅登, 岡田 雅穂, 小山 富生, 山田 哲也, 片山 浩司

    日本心臓血管外科学会雑誌   Vol. 29 ( Suppl. ) page: 187 - 187   2000.1

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  240. 弓部全置換術におけるsequential method施行中の脳内酸素環境について NIRを用いて

    玉木 修治, 岡田 正穂, 六鹿 雅登, 横手 淳, 加藤 紀之, 成田 裕司, 伊藤 正夫, 小山 富生

    The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY   Vol. 47 ( Suppl. ) page: 298 - 298   1999.9

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  241. 大動脈弁位の手術における新しい逆流評価方法

    成田 裕司, 玉木 修治, 加藤 紀之, 横手 淳, 六鹿 雅登, 岡田 正穂, 小山 富生, 山田 哲也, 片山 浩司, 高木 理守

    人工臓器   Vol. 28 ( 4 ) page: S76 - S76   1999.9

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  242. 大動脈弁形成術の新しい術中評価方法

    成田 裕司, 玉木 修治, 伊藤 正夫, 村山 弘臣, 加藤 紀之, 横手 淳, 六鹿 雅登, 岡田 正穂, 小山 富生

    The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY   Vol. 47 ( Suppl. ) page: 222 - 222   1999.9

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  243. これからの体外循環 今後求められる人工心肺システム

    小山 富生, 山田 哲也, 片山 浩司, 高木 理守, 玉木 修治, 横山 幸房, 加藤 紀之, 成田 裕司, 横手 淳, 六鹿 雅登

    体外循環技術   Vol. 26 ( 3 ) page: 25 - 25   1999.8

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  244. The Vacuum Control System for Cardiopulmanary Bypass

    KOYAMA T., YAMADA T., KATAYAMA K., TAKAGI M., TAMAKI S., MURAYAMA H., KATO N., NARITA Y., YOKOTE J., MUTSUGA M.

    Journal of the Japanese Society for Artificial Organs and Tissues   Vol. 28 ( 2 ) page: 517 - 522   1999.4

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    We have developed a new vacuum control system that can keep a hard-shell venous reservoir at a certain target low negative pressure. This device offers assistance with venous drainage and cardiotomy suction during cardiopulmonary bypass (CPB). It consists of an aspiration valve that controls the internal pressure of the hard-shell venous reservoir by releasing the source flow of the vacuum pump to atmospheric pressure. In this study, we used this device in clinical mock-up circuits to evaluate the changes in internal pressure of the hard-shell reservoir. The target pressure of the reservoir varied from-10 mmHg to-70 mmHg. This device could control changes in the internal pressure within a range of 4 mmHg when all cardiotomy suction tubes were switched on and off. This study showed that this device can stabilize the internal pressure of the hard-shell venous reservoir and offers improved handling of venous drainage during CPB. The device would be available not only for venous drainage but for cardiotomy sucking, and would be an applicable system for Minimally Invasive Cardiac Surgery and numerous other clinical uses.

    DOI: 10.11392/jsao1972.28.517

    CiNii Books

    Other Link: http://search.jamas.or.jp/link/ui/1999238271

  245. 拍動流体外循環時の脳内酸素環境の検討

    村山 弘臣, 玉木 修治, 加藤 紀之, 成田 裕司, 横手 淳, 六鹿 雅登, 小山 富生, 山田 哲也, 片山 浩司, 高木 理守

    人工臓器   Vol. 27 ( 4 ) page: S - 57   1998.9

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  246. 人工心肺の血液回収用低陰圧制御装置の開発

    小山 富生, 山田 哲也, 片山 浩司, 高木 理守, 玉木 修治, 村山 弘臣, 加藤 紀之, 成田 裕司, 横手 淳, 六鹿 雅登

    人工臓器   Vol. 27 ( 4 ) page: S - 115   1998.9

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  247. Study of open heart surgical extracorporeal circulation using biocompatible materials.

    Japanese Journal of Extra-Corporeal Technology   Vol. 25 ( 1 ) page: 21 - 24   1998

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    Language:Japanese   Publisher:The Japanese Society of Extra-Corporeal Technology in Medicine  

    DOI: 10.7130/hokkaidoshakai.25.21

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MISC 28

  1. LVAD装着術後患者の退院時下肢筋力は再入院と関連する

    小林聖典, 奥村貴裕, 奥村貴裕, 平岩宏章, 平岩宏章, 近藤徹, 近藤徹, 六鹿雅登, 六鹿雅登, 藤本和朗, 藤本和朗, 碓氷章彦, 碓氷章彦, 室原豊明, 室原豊明

    日本心不全学会学術集会プログラム・抄録集   Vol. 24th (CD-ROM)   2020

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  2. 植込み型LVAD装着患者における積極的な術前リハ介入の経験

    久野智之, 奥村貴裕, 六鹿雅登, 小林聖典, 清水美帆, 林和寛, 碓氷章彦, 室原豊明

    日本心不全学会学術集会プログラム・抄録集   Vol. 20th   2016

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  3. PD-2-7 胸部大動脈再手術症例の検討(PD-2 パネルディスカッション(2)心臓再手術のPitfalls,第114回日本外科学会定期学術集会)

    碓氷 章彦, 成田 裕司, 阿部 知伸, 荒木 善盛, 藤本 和朗, 六鹿 雅登, 徳田 順之, 寺澤 幸枝, 大島 英揮

    日本外科学会雑誌   Vol. 115 ( 2 ) page: 172 - 172   2014.3

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    Language:Japanese   Publisher:一般社団法人日本外科学会  

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  4. OP-097-1 心臓血管外科領域の難治感染症に対するFDG-PET/CTの応用(OP-097 心臓 その他,一般演題,第114回日本外科学会定期学術集会)

    徳田 順之, 大島 英揮, 阿部 知伸, 成田 裕司, 荒木 善盛, 藤本 和朗, 六鹿 雅登, 岡田 正穂, 寺澤 幸枝, 蒔苗 永, 八神 啓, 大野 司, 末永 啓人, 碓氷 章彦

    日本外科学会雑誌   Vol. 115 ( 2 ) page: 486 - 486   2014.3

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    Language:Japanese   Publisher:一般社団法人日本外科学会  

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  5. 左室補助循環サポートBridge to Recoveryをなしえた薬剤性心筋症の一例

    奥村 貴裕, 六鹿 雅登, 深谷 兼次, 澤村 昭典, 森本 竜太, 清水 真也, 河野 裕治, 平敷 安希博, 坂東 泰子, 山田 純生, 竹村 元三, 碓永 章彦, 室原 豊明

    日本心臓病学会誌   Vol. 8 ( Suppl.I ) page: 425 - 425   2013.9

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  6. 劇症型心筋炎で心不全状態が遷延した症例に対し,心臓リハビリテーションを実施し独歩退院した1例

    清水美帆, 小林聖典, 清水優子, 清水真也, 奥村貴裕, 六鹿雅登, 山田純生, 碓氷章彦, 室原豊明

    日本理学療法学術大会(Web)   Vol. 48th   2013

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  7. LVAD装着患者に対する経時的な筋力測定に基づく多面的心臓リハビリテーションが有効であった1例

    小林聖典, 清水美帆, 六鹿雅登, 碓氷章彦, 熊谷宗一郎, 平敷安希博, 室原豊明, 貝沼関志, 河野裕治, 岩津弘太郎, 山田純生

    日本心臓リハビリテーション学会学術集会プログラム抄録集(Web)   Vol. 18th   2012

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  8. Surgical treatment for aortic root dilatation and aortic regurgitation after arterial switch operation

    The Japanese journal of thoracic surgery   Vol. 61 ( 12 ) page: 1043 - 1047   2008.11

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  9. DP-056-6 高度低左心機能の虚血性心筋症に対するSAVE手術・僧帽弁形成術後の僧帽弁置換術・左室形成再々手術の経験(第108回日本外科学会定期学術集会)

    田村 高廣, 市原 利彦, 佐々木 通雄, 堀 昭彦, 六鹿 雅登, 上田 裕一

    日本外科学会雑誌   Vol. 109 ( 2 ) page: 457 - 457   2008.4

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    Language:Japanese   Publisher:一般社団法人日本外科学会  

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  10. DP-055-8 弁膜症における再手術の検討 : その動向と原因(第108回日本外科学会定期学術集会)

    市原 利彦, 佐々木 通雄, 堀 昭彦, 六鹿 雅登, 上田 裕一

    日本外科学会雑誌   Vol. 109 ( 2 ) page: 455 - 455   2008.4

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  11. 98)重症心不全に対し左室形成術とCRTを併用した2例(第129回日本循環器学会東海地方会)

    佐々木 通雄, 市原 利彦, 長内 宏之, 味岡 正純, 六鹿 雅登, 上田 裕一

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 71   page: 1023 - 1023   2007.10

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  12. 49)慢性大動脈解離に対するAortic Tailoring techniqueのPitfall(第129回日本循環器学会東海地方会)

    六鹿 雅登, 加藤 亙, 荒木 義盛, 大島 英揮, 秋田 利明, 碓氷 章彦, 上田 裕一

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 71   page: 1017 - 1017   2007.10

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  13. CABG in a Patient with the Human Immunodeficiency Virus

    Mutsuga Masato, Tamaki Shuji, Yokoyama Yukifusa, Yokote June, Ishimoto Naoyoshi

    Japanese Journal of Cardiovascular Surgery   Vol. 35 ( 3 ) page: 140 - 143   2006.5

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    Language:Japanese   Publisher:The Japanese Society for Cardiouascular Surgery  

    HIV infection is an extremely serious problem, and the number of HIV-infected patients is increasing in the world. The introduction of highly active antiretroviral therapy (HAART) and protease inhibitors (PI) allows maintenance of the inhibition of viral replication and partial reinstating the immune system in most patients. As HIV has changed from a progressive fatal illness to a chronic condition, many infected patients increasingly require diverse health services including cardiac surgery. We report a case of a 68-year-old man with HIV infection who underwent successful coronary artery bypass grafting using a cardiopulmonary bypass. The operative indication were determined according to the CD 4 count and the amount of HIV-RNA. Standard precautions were taken in the same way as for hepatitis B and hepatitis C cases. There was no percutaneous exposure to HIV infected blood. The postoperative course was uneventful, and the patient was discharged with no complications of HIV. The patient has been quite well without any therapy for HIV over one year.

    CiNii Books

  14. 胸部大動脈手術に用いたKnitted Dacron人工血管(Gelseal)の術後拡張に関する検討

    石本 直良, 玉木 修治, 横山 幸房, 重光 希公生, 横手 淳, 六鹿 雅登, 中村 彰太

    The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY   Vol. 53 ( Suppl.II ) page: 582 - 582   2005.9

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  15. Pericardiectomy for Active Constrictive Tuberculous Pericarditis

    Yokote Jun, Tamaki Shuji, Yokoyama Yukifusa, Mutsuga Masato, Nakashima Masaya

    Japanese Journal of Cardiovascular Surgery   Vol. 34 ( 4 ) page: 276 - 278   2005.7

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    A 60-year-old man with constrictive tuberculous pericarditis rapidly progressing after his hospitalization underwent partial pericardiectomy, anterior to the bilateral phrenic nerves through a midline sternotomy without a cardiopulmonary bypass. The results of right cardiac examination a month postoperatively showed the cardiac diastolic dysfunction remained unchanged. However, the results after 6 months and also 3 years postoperatively showed the cardiac function recovered from the constrictive pericarditis. He is free from tuberculosis and heart failure. We should be aware of a sign of heart failure due to constrictive tuberculous pericarditis and take the surgical treatment into consideration. We regard the partial pericardiectomy without cardiopulmonary bypass as one of the effective treatments for constrictive tuberculous pericarditis.

    CiNii Books

  16. 両側頸部病変を有する冠動脈バイパス術の検討(第105回日本外科学会定期学術集会)

    六鹿 雅登, 玉木 修治, 横山 幸房, 重光 希公生, 横手 淳, 中島 正彌, 中村 彰太

    日本外科学会雑誌   Vol. 106   page: 349 - 349   2005.4

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    Language:Japanese   Publisher:一般社団法人日本外科学会  

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  17. Octreotide for Postoperative Chylothorax

    Mutsuga Masato, Tamaki Shuji, Yokoyama Yukifusa, Yokote June, Nakashima Masaya

    Japanese Journal of Cardiovascular Surgery   Vol. 34 ( 1 ) page: 48 - 50   2005.1

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    Language:Japanese   Publisher:The Japanese Society for Cardiouascular Surgery  

    Chylothorax is a serious complication that can jeopardize the outcome of thoracic surgery and prolong hospitalization. We report a 66-year-old man who underwent graft replacement for a distal arch aneurysm, in whom a persistent postoperative chylothorax developed. It was necessary to perform continuous drainage and conservative management. Administration of octreotide sharply decreased the drainage volume and the chylothorax disappeared within 2 weeks. Early administration of octreotide for postoperative chylothorax may shorten the therapeutic period.

    CiNii Books

  18. 123) PTMC後の急性僧帽弁閉鎖不全に対する一手術例(第123回日本循環器学会東海地方会)

    中島 正彌, 玉木 修治, 横山 幸房, 横手 淳, 六鹿 雅登

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 68   page: 918 - 918   2004.10

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  19. Occlusion of the Left Coronary Artery Caused by Fusion of the Aortic Cusp to the Aortic Wall

    Yokoyama Yukifusa, Tamaki Shuji, Kato Noriyuki, Yokote Jum, Mutsuga Masato, Ohata Norihisa

    Japanese Journal of Cardiovascular Surgery   Vol. 32 ( 6 ) page: 366 - 369   2003.11

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    Language:Japanese   Publisher:The Japanese Society for Cardiouascular Surgery  

    A 75-year-old woman suffered from chest compression on effort. Detailed examinations showed aortic valve stenosis and unusual separation of the left coronary artery from the aorta. Surgical exposure revealed that the aortic valve was composed of 3 cusps. Two of 3 cusps were calcified, and another small cusp had fused to the aortic wall. Fusion of the cusp produced a cyst with a hole that was 1.5 mm in diameter. Excision of the cyst disclosed the normal orifice of the left coronary artery. The aortic valve was resected and replaced with an artificial valve. Her postoperative course was uneventful, without any angina pectoris. Jpn. J. Cardiovasc. Surg. 32 : 366-369 (2003)

    CiNii Books

  20. 102) 大動脈解離に対するtotal arch replacement, elephant trunk の pitfall

    大畑 賀央, 玉木 修治, 横山 幸房, 重光 希公生, 加藤 紀之, 横手 淳, 六鹿 雅登

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 66   page: 1069 - 1069   2002.10

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  21. 109)下大静脈に穿通破裂し、うっ血性心不全を呈した総腸骨動脈瘤の一例(日本循環器学会 第116回東海・第101回北陸合同地方会)

    水谷 圭吾, 玉木 修治, 横山 幸房, 伊藤 正夫, 加藤 紀之, 横手 淳, 六鹿 雅登

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 66   page: 933 - 933   2002.4

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  22. <Abstracts> The 6th Meeting of Gifu Endosopic Surgery

      Vol. 50 ( 2 ) page: 53 - 53   2002.3

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    Language:Japanese  

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  23. 8) 著明なTR, MRを認め,両弁置換により心機能の著しい改善を認めたDCMの一例

    坪井 英之, 曽根 孝仁, 近藤 潤一郎, 武川 博昭, 香曽我部 泰, 上杉 道伯, 大橋 能理, 石黒 裕規, 岡田 正穂, 六鹿 雅登, 横手 淳, 成田 祐司, 加藤 紀之, 伊藤 正夫, 横山 幸房, 玉木 修治

    Japanese circulation journal   Vol. 64   page: 897 - 897   2000.10

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  24. 91)解離性大動脈瘤に対する弓部再建のpitfall

    加藤 紀之, 玉木 修治, 村山 弘臣, 成田 裕司, 横手 淳, 六鹿 雅登, 岡田 正穂

    Japanese circulation journal   Vol. 63 ( 3 ) page: 864 - 864   1999.10

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  25. 2)大動脈炎症候群に対してCABG後くり返しPTCAを必要とした1例

    近藤 潤一郎, 曽根 孝仁, 坪井 英之, 武川 博昭, 高木 克昌, 神谷 宏樹, 今井 元, 玉木 修治, 村山 弘臣, 加藤 紀之, 成田 裕司, 横手 淳, 六鹿 雅登

    Japanese circulation journal   Vol. 63 ( 3 ) page: 856 - 856   1999.10

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  26. 98)LMT病変を有する活動期大動脈炎症候群に対するCABGの1例

    横手 淳, 玉木 修治, 村山 弘臣, 加藤 紀之, 成田 裕司, 六鹿 雅登

    Japanese circulation journal   Vol. 63 ( 2 ) page: 743 - 743   1999.8

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  27. 207)特異な形態を示した人工血管置換術後腹部仮性動脈瘤破裂の一治験例

    六鹿 雅登, 玉木 修治, 村山 弘臣, 加藤 紀之, 成田 裕司, 横手 淳

    Japanese circulation journal   Vol. 63 ( 2 ) page: 753 - 753   1999.8

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  28. P-591 大動脈弁置換術における人工弁サイズ決定に関する検討

    村山 弘臣, 玉木 修治, 加藤 紀之, 成田 裕司, 横手 淳, 六鹿 雅登

    日本外科学会雑誌   Vol. 100   page: 459 - 459   1999.2

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Presentations 1

  1. Which is better procedure, using the frozen elephant trunk technique or the classical elephant trunk technique followed with the second stage TEVAR for extensive aortic arch repair?

    The 68th Annual Scientific Meeting of the Japanese Association for Thoracic Surgery 

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    Event date: 2015.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

KAKENHI (Grants-in-Aid for Scientific Research) 13

  1. 感染を予防・制御する抗菌性ポリマー人工血管の創出

    Grant number:22K08954  2022.4 - 2025.3

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    Authorship:Principal investigator 

    Grant amount:\4160000

  2. 経カテーテル僧帽弁置換のための安定した経心房中隔アクセス法の確立

    Grant number:22K08955  2022.4 - 2025.3

  3. 生体タンパク模倣短鎖ペプチドの創成と低侵襲的大動脈瘤治療法開発の試み

    Grant number:22H03155  2022.4 - 2025.3

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    Authorship:Coinvestigator(s) 

  4. Development of alternative artificial vascular grafts for preventing a graft infection using antibacterial polymers

    Grant number:20K21630  2020.7 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

    USUI Akihiko

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    Infected artificial aortic grafts are removed and an operation is necessary for the replacement of a new vascular graft. As standard surgical treatments, rifampin-soaked synthetic prosthetic grafts have been widely used for prevention or treatment of vascular graft infections. However, their effects are not maintained long-term and rifampicin might cause infectious complications with rifampicin-resistance Staphylococcus aureus through reduced antibacterial effects. Thus, an alternative antibacterial aortic graft is required.
    In this study, we designed PVA/poly(METAC) copolymers to have the shape of film or fiber, and it has been shown to have properties including antibacterial activities and low hemolysis. Our results are useful as basic research for development of an alternative antibacterial vascular graft using biocompatible polymers.

  5. Development of antibacterial polymeric films for control of ventricular assist device driveline infections

    Grant number:19K09240  2019.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    TERAZAWA Sachie

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    Authorship:Coinvestigator(s) 

    Implantable ventricular assist devices used for patients with severe heart failure have a "driveline" that penetrates the skin to secure a drive power supply, and always involve the risk of infection. This research aimed to develop an infection preventive material using Poly (METAC), which are cationic polymer having antibacterial properties, in order to prevent driveline infection. We synthesized a copolymer containing a METAC group and succeeded in forming a film by thermally cross-linking it with polyvinyl alcohol (PVA). This film showed water-insoluble, antibacterial effects, and blood compatibility, suggesting that this film may be useful for preventing driveline infection.

  6. Elucidation of the paradox between obstructive pulmonary disease and aortic aneurysms treated with clarithromycin and montelukast

    Grant number:19K09265  2019.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    NARITA Yuji

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    We have reported that administration of clarithromycin (CAM) or montelukast (Mont) inhibit aortic aneurysms (AA) development and progression via their properties of anti-inflammatory effects. Both CAM and Mont are widely used for chronic obstructive pulmonary disease (COPD). In addition, COPD is a risk factor for AA rupture and mortality. In this study, we examined the effects of administration of both CAM and Mont on AA progression in COPD-complicated AA model mice. The results showed that COPD enhanced AA progression and CAM and Mont inhibited development and progression of AA with COPD, suggesting those might be expected to improve prognosis for COPD-complicated AA.

  7. Development of peptide drugs for a new alternative treatment of aortic aneurysm

    Grant number:19H03737  2019.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    USUI Akihiko

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    Authorship:Coinvestigator(s) 

    Rupture of aortic aneurysms (AA) causes exceedingly high mortality rate. Surgical repair is effective treatment to prevent rupture, however, surgical repair in elderly and high-risk patients increase the risk of surgical mortality and perioperative complications. In this study, administration of recombinant protein of secretory leukocyte proteinase inhibitor (SLPI), which has anti-inflammatory properties, attenuated AA growth in mice. To create new peptide drugs, we designed 120 patterns of short-chain peptides which were referenced from amino acids sequence of SLPI by in silico screening. Some short-chain peptides exhibited low level of nitoric oxide (NO) secreted from inflammatory macrophages. However, it is necessary to review cell culture conditions, evaluation system, and design of peptides due to weak anti-inflammatory effects of short-chain peptides. The reviewed results worked as a system for evaluation of short-chain peptides.

  8. Developing the device with biocompatible shape memory polymer for closing the entry of chronic type B aortic dissection

    Grant number:15K10239  2015.4 - 2019.3

    Mutsuga Masato

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    Authorship:Principal investigator 

    Grant amount:\4940000 ( Direct Cost: \3800000 、 Indirect Cost:\1140000 )

    The purpose of this study was to develop the device which is biocompatible and shape memory made by poly caprolactone capable of entry closure for chronic type B aortic dissection.The final destination was clinical application. Using the poly (e-caprolactone) (PCL) derivative prepared in the same way as last year in 2018, we will try to establish the in-vitro and in-vivo experimental system, and examine the usefulness of the developed carrier. It was difficult to develop an ideal biocompatible shape memory polymer and could not be completed. Therefore, The plan for the large animal aortic model was not able to be set up, and the in-vitro experimental system was not created, and the in-vivo experiment with the large animal was completed without any success.

  9. Development of Catheter therapy for ventricular sqptal perforation

    Grant number:23592033  2011 - 2013

    USUI Akihiko

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    Authorship:Coinvestigator(s) 

    We developed a catheter therapy for ventricular septum perforation (VSP) by using a stent-graft placed in the left ventricle. we adapt a net type stent which is knitted by a Nytinol thread. As an initial model, we made a cone-shaped stent-graft but it did not fit with papillary muscles. We changed the design of the stent-graft as a dissymmetry. It covered only with the septum but a pressure power of the septum side particularly the septum base side was weak even with the improved model.We made delivery sheath for direct insertion via the apex and developed an insertion method by using peal off system. We insert a stent-graft into a rubber heart model by using this delivery system. The stent graft can be inserted via the left ventricle apex and has it as a design preserving the directionality by fixing it in the apex. The design decision of the stent-graft which does not affect cardiac function is difficult and remains in the completion of a trial

  10. 総肺静脈還流異常症術後、肺静脈閉塞を予防する生体吸収性薬剤 溶出ナノファイバーの開発

    2008.4 - 2009.3

    公益財団法人 宮田心臓病研究振興基金  医学研究者の学究等に対する奨励金 

    六鹿 雅登

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    Authorship:Principal investigator  Grant type:Competitive

  11. Development of method for cardiovascular tissue engineering-Importance of median smooth muscle layer-

    Grant number:19790970  2007 - 2008

    MUTSUGA Masato

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    Authorship:Principal investigator 

    Grant amount:\3690000 ( Direct Cost: \3300000 、 Indirect Cost:\390000 )

  12. M2マクロファージによる効率的大動脈瘤治療法の確立

    Grant number:22K08933 

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    Authorship:Coinvestigator(s) 

  13. 大動脈瘤におけるマクロファージAIM炎症機構の解明と治療法の開発

    Grant number:22K08932 

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Industrial property rights 1

  1. The Material and Method to develop “Cotton Wool” manufacture for Cardiac therapy

    MUTSUGA Masato

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    Application no:特願2008-111236  Date applied:2008.4

 

Teaching Experience (On-campus) 3

  1. 先天性心疾患

    2021

  2. 人工心臓

    2021

  3. 心臓移植

    2021

 

Social Contribution 1

  1. Tsrumai Open Presentation

    Role(s):Lecturer

    Nagoya University Graduate School of Medicine  2018.12