Updated on 2022/05/16

写真a

 
MUTSUGA Masato
 
Organization
Graduate School of Medicine Program in Integrated Medicine Musculoskeletal and Cutaneous Medicine Associate professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Associate professor

Degree 1

  1. 医学博士 ( 2009.3   名古屋大学 ) 

Research Interests 4

  1. ventricular assist device

  2. minimally invasive cardiac surgery

  3. mitral valve surgery

  4. aortic surgery

Research Areas 1

  1. Life Science / Cardiovascular surgery  / nanofiber

Research History 7

  1. Nagoya University   Department of Cardiac Surgery   Associate professor

    2020.1

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    Country:Japan

  2. Nagoya University   Cardiac Surgery   Lecturer

    2018.6

  3. Nagoya University   Cardiac Surgery   Lecturer of hospital

    2014.4 - 2018.5

  4. Nagoya University   Cardiac Surgery   Designated assistant professor

    2011.7 - 2014.3

  5. University of Alberta   Clinical fellow of Cardiac Surgery   Clinical fellow

    2009.7 - 2011.6

  6. Nagoya University   Cardiac Surgery

    2006.10 - 2009.6

  7. Ogaki municipal hospital   CardioThoracic Surgery

    1996.5 - 2006.9

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Education 2

  1. Nagoya University   Graduate School of Medicine   Cardiac Surgery

    2005.4 - 2009.3

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    Country: Japan

  2. Nagoya University   Graduate School, Division of Medicine

    1990.4 - 1996.3

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    Country: Japan

Professional Memberships 7

  1. JAPAN SURGICAL SOCIETY

  2. JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

  3. JAPANESE SOCIETY OF PEDIATRIC CARDIOLOGY AND CARDIAC SURGERY

  4. THE JAPANESE ASSOCIATION FOR THORACIC SURGERY

  5. THE JAPAN SOCIETY FOR TRANSPLANTATION

  6. THE JAPANESE SOCIETY FOR CARDIOVASCULAR SURGERY

  7. The Japanese Circulation Society

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Papers 83

  1. "Double Cuff" Technique for Modified Bentall Procedure.

    Mutsuga M, Usui A

    Heart, lung & circulation     2021.5

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    Language:English  

    DOI: 10.1016/j.hlc.2021.05.073

    PubMed

  2. Predictors of failure of mitral valve repair using artificial chordae.

    Mutsuga M, Narita Y, Tokuda Y, Uchida W, Ito H, Terazawa S, Nakaguro M, Usui A

    The Annals of thoracic surgery     2021.5

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    Language:English  

    DOI: 10.1016/j.athoracsur.2021.04.084

    PubMed

  3. Pericardioperitoneal and pericardiopleural windows: A drainage technique for the treatment of recurrent cardiac tamponade. A case report.

    Ishida S, Yagami K, Fujita T, Mutsuga M

    International journal of surgery case reports   Vol. 83   page: 105962   2021.5

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    Language:English  

    DOI: 10.1016/j.ijscr.2021.105962

    PubMed

  4. "Millefeuille Technique" by Using Excised Intimal Layers in Repair of Type A Aortic Dissection.

    Mutsuga M, Yagami K, Fujita T, Ishida S, Usui A

    Heart, lung & circulation     2021.4

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    Language:English  

    DOI: 10.1016/j.hlc.2021.04.003

    PubMed

  5. A surgical case for pregnancy-related spontaneous coronary artery dissection.

    Usui R, Mutsuga M, Yoshizumi T, Oshima H, Usui A

    The Annals of thoracic surgery     2021.4

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    Language:English  

    DOI: 10.1016/j.athoracsur.2021.04.023

    PubMed

  6. Midterm Outcomes of Zone 0 Antegrade Endograft Implantation During Type I Hybrid Aortic Arch Repair.

    Banno H, Mutsuga M, Sugimoto M, Tokuda Y, Kodama A, Usui A, Komori K

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     2021.3

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    Language:English  

    DOI: 10.1016/j.ejvs.2021.02.044

    PubMed

  7. Coronary artery aneurysm complicated by pneumothorax with a history of Kawasaki disease

    Ishida Shinichi, Mutsuga Masato, Fujita Takashi, Ito Masao, Okamoto Sawako, Yagami Kei

    JOURNAL OF SURGICAL CASE REPORTS   Vol. 2021 ( 3 ) page: rjab053   2021.3

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  8. Left brachiocephalic vein aneurysm: a case report

    Ueno Harushi, Yazawa Mari, Tsubouchi Hideki, Nakanishi Keita, Sugiyama Tomoshi, Kadomatsu Yuka, Goto Masaki, Ozeki Naoki, Nakamura Shota, Fukui Takayuki, Mutsuga Masato, Yoshikawa Toyofumi Fengshi Chen

    SURGICAL CASE REPORTS   Vol. 7 ( 1 ) page: 66   2021.3

  9. Associations between hemodynamic parameters at rest and exercise capacity in patients with implantable left ventricular assist devices

    Kondo Toru, Okumura Takahiro, Oishi Hideo, Arao Yoshihito, Kato Hiroo, Yamaguchi Shogo, Kuwayama Tasuku, Haga Tomoaki, Yokoi Tsuyoshi, Hiraiwa Hiroaki, Fukaya Kenji, Sawamura Akinori, Morimoto Ryota, Mutsuga Masato, Fujimoto Kazuro, Usui Akihiko, Murohara Toyoaki

    INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS   Vol. 44 ( 3 ) page: 174 - 180   2021.3

  10. Beating-heart total arch replacement for an octogenarian patient with severe heart failure

    Mutsuga Masato, Banno Hiroshi, Tokuda Yoshiyuki, Usui Akihiko

    JOURNAL OF CARDIAC SURGERY   Vol. 36 ( 3 ) page: 1126 - 1129   2021.3

  11. Beating heart left ventricle thrombectomy through mini-left-anterior thoracotomy for a patient with cardiogenic shock

    Mutsuga Masato, Usui Akihiko

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   Vol. 69 ( 3 ) page: 614 - 617   2021.3

  12. Sutures on the Anterior Mitral Leaflet to Prevent Systolic Anterior Motion.

    Tokuda Y, Fujimoto K, Narita Y, Mutsuga M, Usui A

    The Annals of thoracic surgery   Vol. 111 ( 3 ) page: e213 - e215   2021.3

  13. Predictors of residual mitral regurgitation after left ventricular assist device implantation

    Kimura Yuki, Okumura Takahiro, Kazama Shingo, Shibata Naoki, Oishi Hideo, Arao Yoshihito, Kuwayama Tasuku, Kato Hiroo, Yamaguchi Shogo, Hiraiwa Hiroaki, Kondo Toru, Morimoto Ryota, Mutsuga Masato, Fujimoto Kazuro, Usui Akihiko, Murohara Toyoaki

    INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS   Vol. 44 ( 2 ) page: 101 - 109   2021.2

  14. Hypofibrinogenemia can be estimated by the predictive formula in aortic surgery

    Nishi Toshihiko, Mutsuga Masato, Akita Toshiaki, Narita Yuji, Fujimoto Kazuro, Tokuda Yoshiyuki, Nishida Kazuki, Matsui Shigeyuki, Nishiwaki Kimitoshi, Usui Akihiko

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY     2021.1

  15. Cor triatriatum in adulthood with mitral valve regurgitation and atrial fibrillation

    Ishida Shinichi, Yagami Kei, Fujita Takashi, Mutsuga Masato

    JOURNAL OF CARDIAC SURGERY   Vol. 36 ( 1 ) page: 309 - 311   2021.1

  16. Long-term outcome 10 years after free gastroepiploic artery graft for coronary artery bypass surgery.

    Yamamoto T, Mutsuga M, Matsuura A, Miyahara K, Takemura H, Saito S, Otsuka R, Usui A

    The Annals of thoracic surgery     2020.12

  17. Aortic insufficiency associated with Impella that required surgical intervention upon implantation of the durable left ventricular assist device

    Oishi Hideo, Kondo Toru, Fujimoto Kazuro, Mutsuga Masato, Morimoto Ryota, Hirano Ken-ichi, Sawamura Akinori, Kazama Shingo, Kimura Yuki, Shibata Naoki, Kato Hiroo, Arao Yoshihito, Kuwayama Tasuku, Yamaguchi Shogo, Hiraiwa Hiroaki, Okumura Takahiro, Usui Akihiko, Murohara Toyoaki

    JOURNAL OF ARTIFICIAL ORGANS   Vol. 23 ( 4 ) page: 378 - 382   2020.12

  18. Upper thoracoabdominal aortic repair through partial posterior incision of the diaphragm via left thoracotomy

    Ito Hideki, Mutsuga Masato, Tokuda Yoshiyuki, Usui Akihiko

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   Vol. 68 ( 12 ) page: 1594 - 1595   2020.12

  19. Exclusion Technique for Entire Shaggy Aorta Followed by One-Stage Repair of the Aortic Arch and Descending Aorta

    Mutsuga Masato, Ito Hideki, Usui Akihiko

    HEART LUNG AND CIRCULATION   Vol. 29 ( 11 ) page: E269 - E272   2020.11

  20. Which is superior, the frozen elephant trunk technique alone or the classical elephant trunk technique followed by second-stage thoracic endovascular aortic repair for extensive aortic arch repair?

    Mutsuga Masato, Banno Hiroshi, Narita Yuji, Komori Kimihiro, Usui Akihiko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 4 ) page: 657 - 666   2020.11

  21. Mid-term results of Biological Bentall using a larger valve implantation technique

    Mutsuga Masato, Narita Yuji, Usui Akihiko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 4 ) page: 645 - 655   2020.11

  22. Is Hybrid Repair for an Entire Shaggy Aorta Feasible?

    Mutsuga M, Tokuda Y, Narita Y, Terazawa S, Ito H, Usui A

    Heart, lung & circulation     2020.10

  23. Do meteorological factors influence the occurrence of acute aortic dissection? A 10-year retrospective institutional study

    Usui Rena, Mutsuga Masato, Yoshizumi Tomo, Oshima Hideki, Eda Tadahito, Usui Akihiko

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY     2020.10

  24. Commentary: Continuous steady development is made by taking 2 steps forward, 1 step back.

    Mutsuga M, Chen-Yoshikawa TF

    The Journal of thoracic and cardiovascular surgery     2020.10

  25. [Covering Suture Line Using Bovine Pericardium during Mitral Valve Replacement for Third Time Infectious Endocarditis;Report of a Case].

    Ishida S, Fujita T, Yagami K, Mutsuga M

    Kyobu geka. The Japanese journal of thoracic surgery   Vol. 73 ( 11 ) page: 950 - 953   2020.10

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  26. Impella 5.0 for Cardiogenic Shock After Thrombectomy in a Patient With Intraventricular Thrombosis

    Kimura Yuki, Kondo Toru, Mutsuga Masato, Morimoto Ryota, Kazama Shingo, Shibata Naoki, Oishi Hideo, Arao Yoshihito, Kuwayama Tasuku, Kato Hiroo, Yamaguchi Shogo, Hiraiwa Hiroaki, Okumura Takahiro, Fujimoto Kazuro, Usui Akihiko, Murohara Toyoaki

    CANADIAN JOURNAL OF CARDIOLOGY   Vol. 36 ( 10 )   2020.10

  27. Surgery for anomalous papillary muscle directly into the anterior mitral leaflet. Reviewed International journal

    Masato Mutsuga, Yoshiyuki Tokuda, Kazuro Fujimoto, Sachie Terazawa, Hideki Ito, Yuji Narita, Akihiko Usui

    The Annals of thoracic surgery     2020.9

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    Publishing type:Research paper (scientific journal)  

    BACKGROUND: The anomalous insertion of papillary muscle directly into the anterior mitral leaflet is a rare congenital anomaly concomitant with hypertrophic cardiomyopathy. We herein report our surgical technique, which is designed to relieve left ventricular obstruction and preserve the mitral valve and sub-valvular apparatus. METHODS: Among 38 patients who underwent septal myectomy from 2007 to 2020, 4 had an anomalous mitral sub-valvular apparatus with papillary muscle with direct insertion into the anterior mitral leaflets. In all cases, mitral valve repair was accomplished with excision and reconstruction of all anomalous PMs, concomitant with septal myectomy. In other 34 patients, 20 cases needed mitral valve repair with regards to systolic anterior motion by hypertrophic cardiomyopathy. The comparison study was conducted between anomalous papillary muscle group (group A) and the others (group B). RESULTS: There was no early or late death in group A, three early death and two late death in group B. The mean peak gradient in the left ventricle was significantly decreased in both groups. Mitral valve regurgitation grade was also significantly decreased from 3 to 0.5 without valve replacement in group A, from 2 to 0.6 in group B. Six patients needed mitral valve replacement due to the thickness of anterior mitral leaflet in group B. CONCLUSIONS: Hypertrophic obstructive cardiomyopathy associated with the anomalous insertion of papillary muscle can be successfully treated without mitral valve replacement. Excision and reconstruction with the anomalous papillary muscle seems to be a feasible operation to reduce mitral regurgitation and relieve outflow tract obstruction.

    DOI: 10.1016/j.athoracsur.2020.07.031

    PubMed

  28. Association between splenic volume and pulsatility index in patients with left ventricular assist devices

    Hiraiwa Hiroaki, Okumura Takahiro, Sawamura Akinori, Kondo Toru, Kazama Shingo, Kimura Yuki, Shibata Naoki, Arao Yoshihito, Oishi Hideo, Kato Hiroo, Kuwayama Tasuku, Yamaguchi Shogo, Furusawa Kenji, Morimoto Ryota, Fujimoto Kazuro, Mutsuga Masato, Usui Akihiko, Murohara Toyoaki

    INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS     2020.9

  29. Efficacy of Plasma free Hemoglobin for detecting centrifugal pump thrombosis

    Kuroda Taiyo, Mutsuga Masato, Yamada Masao, Yamakawa Masato, Yuhara Satoshi, Hasegawa Hiroki, Yokote Jun, Yokoyama Yukifusa, Yamada Tetsuya, Koyama Tomio, Usui Akihiko

    PERFUSION-UK     2020.9

  30. Bilateral versus single internal thoracic artery grafting in hemodialysis patients

    Munakata Hisaaki, Tajima Kazuyoshi, Kato Wataru, Tanaka Keisuke, Tokuda Yoshiyuki, Mutsuga Masato, Usui Akihiko

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   Vol. 68 ( 8 ) page: 768 - 773   2020.8

  31. Modified sutureless repair using left atrial appendage flap for acquired left-sided pulmonary vein stenosis

    Ito Hideki, Mutsuga Masato, Tokuda Yoshiyuki, Usui Akihiko

    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY   Vol. 58 ( 2 ) page: 395 - 397   2020.8

  32. The incidence and risk factors of hypofibrinogenemia in cardiovascular surgery

    Nishi Toshihiko, Mutsuga Masato, Akita Toshiaki, Narita Yuji, Fujimoto Kazuro, Tokuda Yoshiyuki, Terazawa Sachie, Ito Hideki, Nishiwaki Kimitoshi, Usui Akihiko

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   Vol. 68 ( 4 ) page: 335 - 341   2020.4

  33. Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device

    Hiraiwa Hiroaki, Okumura Takahiro, Shimizu Shinya, Arao Yoshihito, Oishi Hideo, Kato Hiroo, Kuwayama Tasuku, Yamaguchi Shogo, Haga Tomoaki, Yokoi Tsuyoshi, Kondo Toru, Sugiura Yuki, Kano Naoaki, Watanabe Naoki, Fukaya Kenji, Furusawa Kenji, Sawamura Akinori, Morimoto Ryota, Fujimoto Kazuro, Mutsuga Masato, Usui Akihiko, Murohara Toyoaki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 1 ) page: 129 - 134   2020.2

  34. Spinal cord injury following aortic arch replacement

    Tokuda Yoshiyuki, Fujimoto Kazuro, Narita Yuji, Mutsuga Masato, Terazawa Sachie, Ito Hideki, Matsumura Yasumoto, Uchida Wataru, Munakata Hisaaki, Ashida Shinichi, Ono Tsukasa, Nishi Toshihiko, Yano Daisuke, Ishida Shinichi, Kuwabara Fumiaki, Akita Toshiaki, Usui Akihiko

    SURGERY TODAY   Vol. 50 ( 2 ) page: 106 - 113   2020.2

  35. A Floating Stitch on the Anterior Mitral Leaflet Can Eliminate Systolic Anterior Motion in Hypertrophic Obstructive Cardiomyopathy

    Mutsuga Masato, Narita Yuji, Usui Akihiko

    SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY   Vol. 32 ( 2 ) page: 266 - 268   2020

  36. Total resection of an infected aortic arch aneurysm caused by Mycobacterium avium: a case report

    Yagami Kei, Fujita Takashi, Ishida Shinichi, Mutsuga Masato

    JOURNAL OF CARDIOTHORACIC SURGERY   Vol. 14 ( 1 )   2019.8

  37. A functional evaluation of cerebral perfusion for coronary artery bypass grafting patients

    Teramoto Chikao, Mutsuga Masato, Kawaguchi Osamu, Araki Yoshimori, Matsuda Joe, Usui Akihiko

    HEART AND VESSELS   Vol. 34 ( 7 ) page: 1122 - 1131   2019.7

  38. Neurologic Deficit After Aortic Arch Replacement: The Influence of the Aortic Atherosclerosis

    Tokuda Yoshiyuki, Narita Yuji, Fujimoto Kazuro, Mutsuga Masato, Terazawa Sachie, Ito Hideki, Uchida Wataru, Usui Akihiko

    ANNALS OF THORACIC SURGERY   Vol. 108 ( 1 ) page: 107 - 114   2019.7

  39. The efficacy of immediate bridging thoracic endovascular aortic repair for ruptured infected thoracic aortic aneurysms

    Ito Hideki, Mutsuga Masato, Oshima Hideki, Usui Akihiko

    JOURNAL OF VASCULAR SURGERY CASES AND INNOVATIVE TECHNIQUES   Vol. 5 ( 2 ) page: 152 - 155   2019.6

  40. Hemodynamics of cardiac tamponade during extracorporeal membrane oxygenation support in a patient with fulminant myocarditis Reviewed

    Toru Kondo, Ryota Morimoto, Tsuyoshi Yokoi, Shogo Yamaguchi, Tasuku Kuwayama, Tomoaki Haga, Hiroaki Hiraiwa, Yuki Sugiura, Naoki Watanabe, Naoaki Kano, Takeo Ichii, Kenji Fukaya, Akinori Sawamura, Takahiro Okumura, Tomo Yoshizumi, Masato Mutsuga, Kazuro Fujimoto, Naoyuki Matsuda, Akihiko Usui, Toyoaki Murohara

    Journal of Cardiology Cases   Vol. 19 ( 1 ) page: 22 - 24   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.jccase.2018.08.009

    PubMed

  41. Usefulness of lymphography and computed tomography for detecting the site of chyle leakage

    Ito Hideki, Usui Akihiko, Uchida Wataru, Mutsuga Masato

    INDIAN JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY   Vol. 35 ( 1 ) page: 104 - 107   2019.1

  42. Stem Cell Therapy for Aortic Aneurysm: Does the Administered Cell Type Influence the Therapeutic Effects? Reviewed

    Yamawaki-Ogaka A, Fujimoto KL, Mutsuga M, Tokuda Y, Usui A, Narita Y

    J Regen Med.   Vol. 8 ( 1 )   2019

  43. Strategy of Cardiovascular Surgery for Patients With Dementia as Evaluated by Mini-Mental State Examination

    Terazawa Sachie, Oshima Hideki, Narita Yuji, Fujimoto Kazuro, Mutsuga Masato, Tokuda Yoshiyuki, Yoshizumi Tomo, Ito Hideki, Uchida Wataru, Usui Akihiko

    CIRCULATION JOURNAL   Vol. 82 ( 12 ) page: 2998 - 3004   2018.12

  44. The oral administration of clarithromycin prevents the progression and rupture of aortic aneurysm

    Uchida Wataru, Narita Yuji, Yamawaki-Ogata Aika, Tokuda Yoshiyuki, Mutsuga Masato, Fujimoto Kazuro Lee, Abe Tomonobu, Oshima Hideki, Usui Akihiko

    JOURNAL OF VASCULAR SURGERY   Vol. 68 ( 6 ) page: 82S - +   2018.12

  45. The Possibility of Clarithromycin for the Treatment of Type B Aortic Dissection.

    Uchida Wataru, Yamawaki-Ogata Aika, Hideki Ito, Sachie Tarazawa, Tokuda Yoshiyuki, Mutsuga Masato, Fujimoto Kazuro L., Yuji Narita, Usui Akihiko

    CIRCULATION   Vol. 138   2018.11

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  46. Aortic sarcoidosis complicated by a pulmonary artery aneurysm

    Uchida Wataru, Tokuda Yoshiyuki, Mutsuga Masato, Usui Akihiko

    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY   Vol. 54 ( 4 ) page: 786 - 788   2018.10

  47. Usefulness of lymphography and computed tomography for detecting the site of chyle leakage. Reviewed

    Hideki Ito, Akihiko Usui, Wataru Uchida, Masato Mutsuga

    Indian Journal of Thoracic and Cardiovascular Surgery volume   Vol. 35   page: 104 - 107   2018.9

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    Authorship:Last author  

  48. Promising method for management of venoarterial extracorporeal membrane oxygenation: A case of severe heart failure successfully stabilized by “high-flow/vasodilation method” Reviewed

    Toru Kondo, Akinori Sawamura, Takahiro Okumura, Naoaki Kano, Ryota Morimoto, Naoki Watanabe, Hiroaki Hiraiwa, Tasuku Kuwayama, Yuki Sugiura, Tomoaki Haga, Shogo Yamaguchi, Kenji Fukaya, Tsuyoshi Yokoi, Kazuro Fujimoto, Masato Mutsuga, Tomo Yoshizumi, Naoyuki Matsuda, Akihiko Usui, Toyoaki Murohara

    Journal of Cardiology Cases   Vol. 18 ( 2 ) page: 81 - 84   2018.8

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier Ltd  

    We report the case of a 58-year-old man with dilated cardiomyopathy who was hospitalized because of worsening heart failure. As his symptoms were refractory even with the administration of inotropes, he was given peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO) upon transfer to our hospital. On admission, serum creatinine was 2.62 mg/dL and total bilirubin 10.8 mg/dL. The cannulas inserted were 16-Fr for infusion and 21-Fr for drainage. When the blood flow was increased to 2.14 L/min/m2 to improve organ dysfunction, the aortic valve became continuously close with the mean arterial pressure of 85 mmHg. Therefore, we administrated vasodilators to decrease mean arterial pressure, or left ventricular afterload, which achieved opening aortic valve continuously. After the cannula sizes were scaled up to 18Fr for infusion and 24Fr for drainage to gain further blood flow, the aortic valve opened continuously and mean pulmonary pressure decreased. Our strategy to maintain adequate flow rate of VA-ECMO using vasodilator, “high-flow/vasodilation method”, achieved hemodynamic stability. Additionally, the concentration of serum creatinine and total bilirubin gradually decreased to within the normal range, although the patient succumbed 58 days after transfer to our hospital. &lt
    Learning objective: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is often used as a first-line mechanical circulatory support in patients with severe heart failure. However, its management is difficult and not established. We discuss the efficacy and potency of our “high-flow/vasodilation method” in the management of VA-ECMO.&gt

    DOI: 10.1016/j.jccase.2018.05.002

    Scopus

    PubMed

  49. Non-Bacterial Thrombotic Endocarditis Associated With Crohn's Disease.

    Uchida W, Mutsuga M, Ito H, Oshima H, Usui A

    The Annals of thoracic surgery   Vol. 105 ( 5 ) page: E199 - E201   2018.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.athoracsur.2017.12.005

    Web of Science

    PubMed

  50. [Future Aspects of Bio-Bentall Procedure].

    Mutsuga M, Usui A

    Kyobu geka. The Japanese journal of thoracic surgery   Vol. 71 ( 1 ) page: 37 - 42   2018.1

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  51. Hemorrhagic Pericardial Cyst Complicated with Constrictive Pericarditis

    Oguri Mitsutoshi, Ohguchi Shiou, Takahara Kunihiko, Kawamura Yoshihiro, Yokoi Yuki, Izumi Kazuhiro, Fujita Takashi, Yagami Kei, Mutsuga Masato

    INTERNAL MEDICINE   Vol. 57 ( 24 ) page: 3565 - 3568   2018

  52. Virtual angioscopy with multidetector computed tomography for the diagnosis of pannus formation in mechanical aortic valves

    Mutsuga Masato, Narita Yuji, Oshima Hideki, Usui Akihiko

    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY   Vol. 52 ( 6 ) page: 1233 - 1233   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ejcts/ezx234

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    PubMed

  53. Clinical outcomes and quality of life after surgery for dilated ascending aorta at the time of aortic valve replacement; wrapping versus graft replacement

    Abe Tomonobu, Terazawa Sachie, Ito Hideki, Tokuda Yoshiyuki, Fujimoto Kazuro, Mutsuga Masato, Narita Yuji, Oshima Hideki, Usui Akihiko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 79 ( 4 ) page: 443 - 451   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18999/nagjms.79.4.443

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    PubMed

  54. Entire Circumferential Reconstruction of the Right Atrium Surrounded by Angiosarcoma

    Hibino Makoto, Abe Tomonobu, Oshima Hideki, Narita Yuji, Mutsuga Masato, Fujimoto Kazuro L., Tokuda Yoshiyuki, Yamana Koji, Kuroda Taiyo, Usui Akihiko

    ANNALS OF THORACIC SURGERY   Vol. 103 ( 6 ) page: E483 - E485   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.athoracsur.2016.11.032

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    PubMed

  55. [Total Arch Replacement Using Manufactured Frozen Elephant Trunk after Acute Type-A Dissection Repair].

    Hibino M, Mutsuga M, Oshima H, Narita Y, Abe T, Fujimoto K, Tokuda Y, Usui A

    Kyobu geka. The Japanese journal of thoracic surgery   Vol. 70 ( 4 ) page: 281-285   2017.4

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    PubMed

  56. The efficacy and risk of cerebrospinal fluid drainage for thoracoabdominal aortic aneurysm repair: a retrospective observational comparison between drainage and non-drainage

    Sugiura Junya, Oshima Hideki, Abe Tomonobu, Narita Yuji, Araki Yoshimori, Fujimoto Kazuro, Mutsuga Masato, Usui Akihiko

    INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY   Vol. 24 ( 4 ) page: 609 - 614   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/icvts/ivw436

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    PubMed

  57. Early and Late Outcomes of Thoracic Aortic Surgery in Hemodialysis Patients (vol 102, pg 1282, 2016)

    M. Hibino, H. Oshima, Y. Narita, T. Abe, M. Mutsuga, K. L. Fujimoto, Y. Tokuda, S. Terazawa, H. Ito, A. Usui

    ANNALS OF THORACIC SURGERY   Vol. 103 ( 1 ) page: 366 - 366   2017.1

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    Language:English   Publisher:ELSEVIER SCIENCE INC  

    Web of Science

  58. The changes of aortic diameter after aortic repair with aortic tailoring technique for chronic type B aortic dissection Reviewed

    Hiroto Suenaga, Akihiko Usui, Masato Mutsuga, Hideki Oshima, Tomonobu Abe, Yuji Narita, Kazuro Fujimoto, Yoshiyuki Tokuda

    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY   Vol. 50 ( 6 ) page: 1118 - 1123   2016.12

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    Publishing type:Research paper (scientific journal)   Publisher:OXFORD UNIV PRESS INC  

    OBJECTIVES: Aortic repair with aortic tailoring of the false lumen can preserve the true lumen and intercostal arteries naturally. It is a useful surgical strategy to prevent paraplegia. However, aortic remodelling of tailored segments in a late phase after surgery is another concern. This study investigates the destiny of aortic remodelling of tailored aorta.
    METHODS: From June 2004 to April 2013, 21 consecutive patients underwent aortic tailoring operation for chronic type B aortic dissecting aneurysm. The mean age at operation was 60 +/- 10 years (range, 43-77). The tailored aortic segments were followed by serial CT scanning with the mean follow-up period of 46 +/- 32 months (range, 2-103).
    RESULTS: There were no operative deaths but paraplegia in 1, stroke in 1 and reversible renal failure in 2 patients. There were two late deaths: one due to pneumonia and the other due to aneurysmal rupture of the abdominal aorta. Eighteen patients revealed a completely thrombosed false lumen and no expansion of the tailored aorta, with it remaining less than 40 mm in diameter during follow-up. However, 3 cases were associated with a patent false lumen and 2 cases revealed aortic events. The aortic event-free rate at 5 years was 95 +/- 5.1% in all patients and 66 +/- 27% in patients in the patent false lumen group.
    CONCLUSIONS: Aortic tailoring is a useful surgical technique for chronic type B aortic dissection. Paraplegia and ischaemia of other visceral organs could less likely occur. Patients with a completely thrombosed false lumen revealed no aortic events; however, a patent false lumen was associated with a high risk of aortic events.

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  59. The long-term results and changing patterns of biological valves at the mitral position in contemporary practice in Japan

    Abe Tomonobu, Ito Hideki, Mutsuga Masato, Fujimoto Kazuro, Terazawa Sachie, Narita Yuji, Oshima Hideki, Usui Akihiko

    Nagoya Journal of Medical Science   Vol. 78 ( 4 ) page: 369 - 376   2016.11

  60. Early and Late Outcomes of Thoracic Aortic Surgery in Hemodialysis Patients Reviewed

    Makoto Hibino, Hideki Oshima, Yuji Narita, Tomonobu Abe, Masato Mutsuga, Kazuro L. Fujimoto, Yoshiyuki Tokuda, Sachie Terazawa, Hideki Ito, Akihiko Usui

    ANNALS OF THORACIC SURGERY   Vol. 102 ( 4 ) page: 1282 - 1288   2016.10

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    Background. The number of cardiovascular surgeries among hemodialysis patients is increasing according to the growing population of hemodialysis patients; however, the clinical outcome has not yet been clarified, especially in thoracic aortic surgery. The purpose of this study was to assess the early and late outcomes of thoracic aortic surgery in hemodialysis patients.
    Methods. We retrospectively analyzed the outcomes of 700 consecutive open thoracic aortic surgeries from 2002 to 2014. We identified 21 patients receiving preoperative hemodialysis (group HD) and 679 patients not receiving preoperative hemodialysis (group N). The patients were predominantly male, had diabetes mellitus and cardiogenic shock, and had less hyperlipidemia and elective surgery in group HD. The early and late outcomes were compared between 21 patients in each group using a propensity-score matched analysis.
    Results. The hospital stay and intensive care unit stay were significantly longer in group HD even after matching. The 30-day mortality and inhospital mortality showed no significant differences, whereas the rate of postoperative pneumonia was significantly higher in group HD compared with the matched group N (p=0.0067). The 1-year, 3-year, and 7-year survival rates in group HD were 73.4%, 45.7%, and 30.5%, respectively, which were significantly poorer than that of group N both in the prematched (p < 0.001) and matched analyses (p=0.0027).
    Conclusions. Considering the various operative risks associated with hemodialysis patients, the early mortality rate is acceptable, even after the association with many respiratory complications. Although hemodialysis patients have a compromised prognosis after surgery, excessive hesitation to perform thoracic aortic surgery may be avoided. (C) 2016 by The Society of Thoracic Surgeons

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  61. Extended total arch replacement via the L-incision approach: single-stage repair for extensive aneurysms of the aortic arch Reviewed

    Yoshiyuki Tokuda, Hideki Oshima, Yuji Narita, Tomonobu Abe, Masato Mutsuga, Kazuro Fujimoto, Sachie Terazawa, Hideki Ito, Makoto Hibino, Wataru Uchida, Kimihiro Komori, Akihiko Usui

    INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY   Vol. 22 ( 6 ) page: 750 - 755   2016.6

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    OBJECTIVES: Total arch replacement via the L-incision approach (a combination of left anterior thoracotomy and upper median sternotomy) can be used to achieve more extensive replacement.
    METHODS: In the period between 2002 and 2014, 279 total arch replacement procedures were performed. After excluding cases of acute aortic dissection and cases involving concomitant, hybrid or frozen elephant trunk procedures, patients who underwent isolated total arch replacement via an L-incision (n = 29) and via median sternotomy (n = 143) were identified and the data pertaining to their cases were analysed.
    RESULTS: Operative mortality was higher in the L-incision group than in the median sternotomy group (6.9 vs 2.1%); however, the difference was not statistically significant. The L-incision group displayed a higher rate of respiratory complications, including pneumonia (28 vs 7.0%, P = 0.0034), the need for tracheostomy (17 vs 2.1%, P = 0.0038) and pulmonary haemorrhage (6.9 vs 0%, P = 0.028). The rate of paraplegia was similar between the groups (0 vs 1.4%, P = 1.00), despite the wider range replaced via the L-incision approach (7.3 +/- 1.5 vs 4.7 +/- 0.8 anatomical zones, P < 0.001). The rates of other complications and functional recovery were similar. The long-term survival (73 vs 84% at 5 years) and aortic event-free rates (94 vs 96% at 5 years) were similar in both groups.
    CONCLUSIONS: A combination of left anterior thoracotomy and upper median sternotomy can be applied to the single-stage repair of extended aneurysms with acceptable results in appropriately selected patients.

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  62. [Aortic Valve Replacement of Quadricuspid Valve with Regurgitation].

    Yagami K, Oshima H, Narita Y, Abe T, Araki Y, Fujimoto K, Mutsuga M, Terazawa S, Ito H, Kuwabara F, Usui A

    Kyobu geka. The Japanese journal of thoracic surgery   Vol. 69 ( 4 ) page: 321 - 4   2016.4

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  63. Hybrid versus open repair of aortic arch aneurysms: comparison of postoperative and mid-term outcomes with a propensity score-matching analysis Reviewed

    Yoshiyuki Tokuda, Hideki Oshima, Yuji Narita, Tomonobu Abe, Yoshimori Araki, Masato Mutsuga, Kazuro Fujimoto, Sachie Terazawa, Kei Yagami, Hideki Ito, Kiyoto Yamamoto, Kimihiro Komori, Akihiko Usui

    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY   Vol. 49 ( 1 ) page: 149 - 156   2016.1

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    OBJECTIVES: Operative strategies for repairing aortic arch aneurysms should be re-evaluated following recent technical advances.
    METHODS: Of 364 patients who underwent aortic arch repair between 2002 and 2014, 58 were high-risk subjects who received isolated hybrid arch repair (HAR) via median sternotomy (type I n = 32, type II n = 1 and type III n = 25). During this period, excluding patients with type A dissection or extensive aneurysms, 124 patients received isolated open arch repair via median sternotomy. The patients in the HAR and open arch repair groups were compared. A propensity score-matching analysis was applied to adjust for baseline risk factors.
    RESULTS: The patients in the HAR group were older (77 years +/- 6 vs 69 +/- 9, P < 0.0001), exhibited a greater rate of malignancy (21 vs 4.8%, P = 0.0022) and had higher logistic EuroSCORE values (31 +/- 18 vs 20 +/- 15, P < 0.0001) than those in the open arch repair group. Following propensity score matching creating 38 matched pairs, the differences in preoperative risk diminished. Operative complications, including the mortality rate (2.6 vs 0%), were similar between the groups. Apart from the lower rates of cardiopulmonary bypass (CPB) and circulatory arrest, there was no apparent superiority of HAR with respect to patient recovery. The mean follow-up duration was 52.5 months, during which the rate of freedom from aortic events in the HAR and open arch repair groups was 79 and 99% at 24 months, respectively (P < 0.0001).
    CONCLUSIONS: HAR achieves equivalent short-term results to standard open arch repair, with a decreased need for CPB. However, considering the inferior mid-term outcomes of this procedure, its indications should be limited to high-risk patients.

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  64. An Epicardial Mesothelial Cyst Attached to the Ascending Aorta Reviewed

    Yoshihito Suenaga, Tomonobu Abe, Masato Mutsuga, Yoshimori Araki, Akihiko Usui

    HEART SURGERY FORUM   Vol. 18 ( 5 ) page: E194 - E195   2015.10

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    An epicardial mesothelial cyst, which can be defined as a mesothelial cyst attached to the epicardium surrounding the heart and the great vessels inside the pericardial sac, is a rare condition. We herein report a case of epicardial cyst, which was attached to the ascending aorta. The patient was a 76-year-old male who underwent coronary artery bypass surgery, and the cyst was found incidentally. It was approximately 5 cm in diameter, and histological examination confirmed mesothelial cell origin. The ascending aorta has not previously been reported as the origin of an epicardial mesothelial cyst. This case gives new insight into the embryology of these cysts.

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  65. The number of cardiovascular surgeries in Japan may decrease after 2020

    Usui Akihiko, Abe Tomonobu, Araki Yoshimori, Narita Yuji, Mutsuga Masato, Oshima Hideki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 77 ( 3 ) page: 389 - 398   2015.8

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  66. Impact of Surgical Stroke on the Early and Late Outcomes After Thoracic Aortic Operations Reviewed

    Noritaka Okada, Hideki Oshima, Yuji Narita, Tomonobu Abe, Yoshimori Araki, Masato Mutsuga, Kazuro L. Fujimoto, Yoshiyuki Tokuda, Akihiko Usui

    ANNALS OF THORACIC SURGERY   Vol. 99 ( 6 ) page: 2017 - 2023   2015.6

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    Background. Thoracic aortic operations still remain associated with substantial risks of death and neurologic injury. This study investigated the impact of surgical stroke on the early and late outcomes, focusing on the physical status and quality of life (QOL).
    Methods. From 1986 to 2008, 500 patients (aged 63 +/- 13 years) underwent open thoracic aortic repair for root and ascending (31%), arch (39%), extended arch (10%), and descending and thoracoabdominal (19%) aneurysms. Brain protection consisted of retrograde cerebral perfusion (52%), antegrade cerebral perfusion (29%), and simple deep hypothermic circulatory arrest (19%). Surgical stroke was defined as a neurologic deficit persisting more than 72 hours after the operation. QOL was assessed with the Short-Form 36 Health Survey Questionnaire 5.9 +/- 4.2 years after the operation.
    Results. Stroke occurred in 10.3% of patients. Hospital mortality was 21% in the stroke group and 2.7% in the nonstroke group (p < 0.001). At hospital discharge, 76% of survivors in the stroke group had permanent neurologic deficits (PNDs), with sustained tracheostomy in 39%, tube feeding in 46%, and gastrostomy in 14%, and 89% required transfer to other facilities. PND was an independent risk factor for late death (hazard ratio, 2.29; 95% confidence interval, 1.04 to 4.62; p = 0.041) in a multivariate analysis. The physical component of the QOL score was worse in the PND group (51% vs 100%; p = 0.039), whereas the mental component was similar in both groups (14% vs 14%).
    Conclusions. Surgical stroke is associated with high hospital mortality and PNDs that decrease late survival and the physical component score of the QOL survey. (C) 2015 by The Society of Thoracic Surgeons

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  67. Influence of the characteristics of Japanese patients on the long-term outcomes after aortic valve replacement: results of a microsimulation Reviewed

    Tomonobu Abe, Hideki Oshima, Yuji Narita, Yoshimori Araki, Masato Mutsuga, Kazuro Fujimoto, Yoshiyuki Tokuda, Sachie Terazawa, Kei Yagami, Akihiko Usui

    General Thoracic and Cardiovascular Surgery   Vol. 63 ( 5 ) page: 260 - 266   2015.5

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    Other Link: http://link.springer.com/article/10.1007/s11748-014-0499-2/fulltext.html

  68. An L-Shaped Incision for an Extensive Thoracic Aortic Aneurysm and Coronary Artery Bypass Using the Left Internal Thoracic Artery. Reviewed

    Abe T, Suenaga H, Oshima H, Araki Y, Mutsuga M, Fujimoto K, Usui A

    Aorta (Stamford, Conn.)   Vol. 3 ( 2 ) page: 86 - 9   2015.4

  69. IMPACT OF THE INTRAOPERATIVE USE OF FIBRINOGEN CONCENTRATE FOR HYPOFIBRINOGENEMIA DURING THORACIC AORTIC SURGERY Reviewed

    Yoshimori Araki, Akihiko Usui, Hideki Oshima, Tomonobu Abe, Kazuro Fujimoto, Masato Mutsuga, Yoshiyuki Tokuda, Sachie Terazawa, Kei Yagami, Hideki Ito

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 77 ( 1-2 ) page: 265 - 273   2015.2

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    Thoracic aortic surgery often causes massive bleeding due to coagulopathy. Hypofibrinogenemia is one of the major causative factors, but the utility of the intraoperative administration of fibrinogen concentrate has not yet been proven. The aim of this study was to estimate incidence of hypofibrinogenemia and to evaluate efficacy of using fibrinogen concentrate intraoperatively. The perioperative serum fibrinogen levels (SFL) had routinely been measured in consecutive 216 thoracic aortic surgeries performed from 2010 to 2012. Fibrinogen concentrate was principally used for hypofibrinogenemia (< 150 mg/dl of SFL) at cardiopulmonary bypass (CPB) termination. The patients who received fibrinogen concentrate (FIB group) were compared with the patients who did not received (non Fib group). There were 147 patients (68%) in FIB group at a dose of 5.5 +/- 3.5 g. The SFL were dramatically decreased with values of 164 +/- 71 mg/dl at CPB termination, compared to the preoperative SFL of 352 +/- 131 mg/dl. In the FIB group, the intraoperative and postoperative SFLs were 139 +/- 53 and 262 +/- 75 (mg/dl), respectively. Thus the SFL was recovered quickly by the administration. 110 cases (51%) showed hypofibrinogenemia at the termination of CPB. The predictors of hypofibrinogenemia were preoperative SFL < 250 mg/dl, emergency surgery and thracoabdominal aortic surgery. Hypofibrinogenemia frequently was observed at the termination of CPB during thoracic aortic surgery. Administering intraoperative fibrinogen concentrate appears to be a useful option to treat coagulopathy.

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  70. A comparative study of two types of sternal pins used for sternal closure: poly-L-lactide sternal pins versus uncalcined hydroxyapatite poly-L-lactide sternal pins Reviewed

    Xian-ming Fu, Hideki Oshima, Yoshimori Araki, Yuji Narita, Masato Mutsuga, Noritaka Okada, Tomohiro Tsunekawa, Akihiko Usui

    JOURNAL OF ARTIFICIAL ORGANS   Vol. 16 ( 4 ) page: 458 - 463   2013.12

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    Bioabsorbable poly-l-lactide (PLLA) sternal pins are applied to reinforce sternal closure during cardiac surgery. However, these pins lack osteoconductivity. A new bioabsorbable sternal pin with osteoconductivity, made of uncalcined hydroxyapatite and poly-l-lactide (u-HA-PLLA) has been developed. This study was conducted to compare the two types of sternal pins in terms of sternal stability and healing after median sternotomy. Between October 2006 and January 2012, 105 patients underwent aortic surgery for aortic aneurysms or dissection via median sternotomy and sternal closure with sternal pins. Among these patients, 75 were followed for 12 months using serial computed tomography (CT). PLLA sternal pins were used in 30 patients (group A) and u-HA-PLLA sternal pins were used in 45 patients (group B). The incidence rates of transverse sternal dehiscence, anteroposterior displacement and complete sternal fusion were evaluated using CT. The cross-sectional cortical bone density area (CBDA) of the sternum around the sternal pins was examined to evaluate the osteoconductivity of the sternal pins. There were no significant differences between groups A and B in the sternal dehiscence rate (6.7 vs 4.4 %), sternal displacement rate (6.7 vs 2.2 %) or 12-month sternal fusion rate (63.3 vs 73.3 %). The CBDA around the sternal pins significantly increased between discharge and 12 months after surgery in group B (P < 0.001) but not in group A. These results show that u-HA-PLLA sternal pins exhibit certain osteoconductivity; however, both PLLA and u-HA-PLLA sternal pins provide comparable clinical outcomes regarding sternal stability and healing.

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  71. [Surgical strategy for extended aortic arch aneurysm].

    Araki Y, Mutsuga M, Tokuda Y, Okada M, Abe T, Oshima H, Usui A

    Kyobu geka. The Japanese journal of thoracic surgery   Vol. 66 ( 11 ) page: 960 - 4   2013.10

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  72. Detection of thoracic aortic prosthetic graft infection with 18F-fluorodeoxyglucose positron emission tomography/computed tomography Reviewed

    Yoshiyuki Tokuda, Hideki Oshima, Yoshimori Araki, Yuji Narita, Masato Mutsuga, Katsuhiko Kato, Akihiko Usui

    European Journal of Cardio-thoracic Surgery   Vol. 43 ( 6 ) page: 1183 - 1187   2013.6

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    OBJECTIVES: To investigate the diagnostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in detecting thoracic aortic prosthetic graft infection. METHODS: Nine patients with clinically suspected thoracic aortic graft infection underwent FDG-PET/CT scanning. In these patients, the diagnoses could not be confirmed using conventional modalities. The patients' clinical courses were retrospectively reviewed. RESULTS: On the basis of surgical, microbiological and clinical follow-up findings, the aortic grafts were considered infected in 4 patients and not infected in 5. All 4 patients with graft infection (root: 2 cases, arch: 1 case and descending: 1 case) eventually underwent in situ re-replacement. Two of the 4 patients also had abdominal grafts
    however, only the thoracic grafts were replaced because uptake was low around the abdominal grafts. The maximal standardized uptake value (SUVmax) in the perigraft area was higher in the infected group than in the non-infected group (11.4 ± 4.5 vs 6.9 ± 6.4), although the difference was not statistically significant. According to the receiver operating characteristic analysis, SUVmax &gt
    8 appeared to be the cut-off value in distinguishing the two groups (sensitivity: 1.0 and specificity: 0.8). CONCLUSIONS: FDG-PET/CT is useful for confirming the presence of graft infection by detecting high uptake around grafts and excluding other causes of inflammation. An SUVmax value greater than 8 around a graft suggests the presence of graft infection. In addition, FDG-PET/CT can be used to clarify the precise extent of infection. This is especially useful if multiple separated prosthetic grafts have been implanted. © The Author 2013. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

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  73. [Recurrence of cardiac myxoma in the left atrial after 28 years; report of a case].

    Takanohashi A, Usui A, Mutsuga M, Tokuda Y, Araki Y, Narita Y, Oshima H, Ueda Y

    Kyobu geka. The Japanese journal of thoracic surgery   Vol. 65 ( 12 ) page: 1089 - 92   2012.11

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  74. Fast-track extubation after modified Fontan procedure Reviewed

    Masato Mutsuga, Luis G. Quinonez, Andrew S. Mackie, Colleen M. Norris, B. Elaine Marchak, Jennifer M. Rutledge, Ivan M. Rebeyka, David B. Ross

    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY   Vol. 144 ( 3 ) page: 547 - 52   2012.9

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    Objective: In 2007, we introduced a policy to plan to extubate all patients after a modified Fontan procedure in the operating room. Our objective was to review the feasibility, safety, and clinical outcomes of this approach.
    Methods: Patients who underwent a modified Fontan operation between May 2004 and May 2010 were reviewed.
    Results: Ninety-seven patients underwent a modified Fontan operation (mean age, 3.9 +/- 2.2 years; mean weight, 15.1 +/- 5.0 kg); 46 patients (47%) were extubated in the operating room (group A). Nineteen patients were extubated in the intensive care unit within 24 hours (group B), and 32 patients had delayed extubation (group C). The 3 groups were not significantly different with respect to preoperative characteristics. Twenty-four hours postoperatively, group A had a lower mean central venous pressure compared with patients in group B or C (13 vs 14 vs 17 mm Hg, respectively, P <. 001); a higher base excess (0.4 vs -1.3 vs -3.4, P <. 001); a lower fluid balance (234 vs 514 vs 730 mL, P <. 001); and a lower inotrope score (4.6 vs 6.7 vs 10.8, P <. 001). Group C had a longer median intensive care unit length of stay (2 vs 3 vs 6 nights, P = .01), kept their chest tubes longer (8 vs 9 vs 15 days, P = .001), and had a longer median hospital length of stay (9 vs 11 vs 21 days, P = .001).
    Conclusions: Extubation in the operating room after a modified Fontan procedure seems feasible. This approach is associated with improved early postoperative hemodynamics, earlier time to chest tube removal, and shorter intensive care unit and hospital lengths of stay. (J Thorac Cardiovasc Surg 2012; 144:547-52)

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  75. The Clinical Outcomes of Prolonged Donor Ischemic Time in Adult Patients Undergoing Heart Transplantation. A Single Center Experiences in Canada

    Mutsuga M., Wang S., MacArthur R., Mullen J., Modry D., Ross D., Meyer S.

    JOURNAL OF HEART AND LUNG TRANSPLANTATION   Vol. 31 ( 4 ) page: S93 - S94   2012.4

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  76. Spinal cord protection during a thoracoabdominal aortic repair for a chronic type B aortic dissection using the aortic tailoring strategy Reviewed

    Masato Mutsuga, Yuji Narita, Yoshimori Araki, Atsuo Maekawa, Hideki Oshima, Akihiko Usui, Yuichi Ueda

    INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY   Vol. 11 ( 1 ) page: 15 - 18   2010.7

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    This study evaluated the clinical advantage of a novel technique to reconstruct a true lumen with aortic wall tailoring for aortic repair (aortic tailoring) or the reimplantation of intercostal arteries (vascular tube) in a chronic type B aortic dissection. Thirty-three consecutive extended thoracoabdominal aortic repairs have been performed for chronic type B dissection since 2000. The novel strategy was applied in 17 cases since 2004 including eight cases of aortic repair (group A) and nine cases of a vascular tube (group B). The other 16 cases were graft interposition in five and no reimplantation in 11 for group C. There were no surgical deaths in either group A or B, and only one late death in group C. No patients sustained transient or permanent paraplegia in group A and B, while three cases of paraplegia occurred in group C (18.8%). All of the intercostal arteries were well preserved in group A and an average of 9.8 intercostal arteries for nine patients were reimplantated in group B. The present technique can optimally preserve the intercostal arteries maximally and showed an excellent surgical mortality and morbidity, especially with regard to the protection of the spinal cord. (C) 2010 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.

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  77. Effects of Extracellular Matrix on Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells into Smooth Muscle Cell Lineage: Utility for Cardiovascular Tissue Engineering Reviewed

    Shuichi Suzuki, Yuji Narita, Aika Yamawaki, Yosuke Murase, Makoto Satake, Masato Mutsuga, Hideki Okamoto, Hideaki Kagami, Minoru Ueda, Yuichi Ueda

    CELLS TISSUES ORGANS   Vol. 191 ( 4 ) page: 269 - 280   2010

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    Background: Bone marrow-derived mesenchymal stem cells (MSCs) can differentiate into various types of cell, and the extracellular matrix (ECM) is acknowledged to be important for the regulation of cell functions. In this study, we demonstrated the effects of ECMs on the differentiation of human bone marrow-derived MSCs into a smooth muscle cell (SMC) lineage. Methods: Human MSCs (hMSCs) were cultured on dishes coated with 3 types of ECM including laminin (LM), collagen type IV (Col-IV) and fibronectin for 7 days, and simultaneously cultured on a noncoated dish as a control. Cell numbers of these cultured hMSCs were counted, and their expression of SMC-specific genes and proteins was evaluated. hMSCs were then seeded on LM-coated biodegradable sheets and implanted into rat subcutaneous space. After 2 weeks of implantation, these tissues were evaluated. Results: The number of hMSCs was significantly increased by culture on Col-IV-coated dishes. The expression of SMC-specific genes and proteins (alpha-smooth muscle actin, ASMA; h1-calponin, CALP) in hMSC was significantly upregulated from culture on LM-coated dishes. LM-coated sheets showed
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    a significantly increased expression of ASMA and CALP protein in vivo. Moreover, a fully differentiated marker (SM2) was expressed in the in vivo implanted hMSCs in the course of 2 weeks on the LM-coated sheet. Conclusion: These results suggest that the signal transduction of the cell-matrix interaction for the differentiation of hMSCs into SMCs was activated when cultured with LM. LM-coated materials may thus be useful for cardiovascular tissue engineering. Copyright (C) 2009 S. Karger AG, Basel

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  78. Institutional report - Congenital development of novel drug-eluting biodegradable nano-fiber for prevention of postoperative pulmonary venous obstruction Reviewed

    Masato Mutsuga, Yuji Narita, Aika Yamawaki, Makoto Satake, Hiroaki Kaneko, Akihiko Usui, Yuichi Ueda

    Interactive Cardiovascular and Thoracic Surgery   Vol. 8 ( 4 ) page: 402 - 6; discussion 406   2009.4

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    Pulmonary venous obstruction (PVO) after correction of total anomalous pulmonary venous connection (TAPVC) frequently occurs due to intimal-hyperplasia and the required re-operation. We have developed a novel sustained-release drug delivery system, using Tacrolimuseluting biodegradable nano-fiber (TEBN). It consists of nano-scale fiber composed of biodegradable polymer and Tacrolimus. This study evaluated the effects of TEBN for prevention of venous anastomotic stricture in a rat model to apply to PVO operation. Tacrolimus was incorporated into poly (L-lactide-co-glycolide). The venous stricture model was made by rat inferior vena cava anastomosis. The IVC anastomosis was covered with TEBN with 1.0 wt% Tacrolimus (n=12) or without TEBN as a control (n=12), and evaluated histologically at 1, 2, and 4 weeks after operation. The ratio of intimal area was significantly reduced in the TEBN group compared with the control group (ratio
    1 week: 0.43 ± 0.26 vs. 0.07 ± 0.04, P=0.04, 2 weeks: 0.39 ± 0.19 vs. 0.05 ± 0.02, P=0.01, 4 weeks: 0.31±0.15 vs. 0.09 ± 0.04, P=0.03, control vs. TEBN, respectively). Histological findings showed endothelialization along the inner surface of the vein even in TEBN. The TEBN reduced intimal hyperplasia and preserved endothelialization even in a venous stricture. These results suggested that this strategy might be useful for prevention of recurrent PVO after TAPVC correction. © 2009 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.

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  79. A new strategy for prevention of anastomotic stricture using tacrolimus-eluting biodegradable nanofiber Reviewed

    Masato Mutsuga, Yuji Narita, Aika Yamawaki, Makoto Satake, Hiroaki Kaneko, Yoshihiro Suematsu, Akihiko Usui, Yuichi Ueda

    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY   Vol. 137 ( 3 ) page: 703 - 709   2009.3

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    Objective: We developed a novel sustained drug-eluting device using tacrolimus-eluting biodegradable nanofiber to prevent anastomotic stricture and evaluated the effects in a rat abdominal aortic anastomosis model.
    Methods: In vitro and in vivo tacrolimus release tests for tacrolimus-eluting biodegradable nanofiber were performed to confirm its sustained release. To verify the prevention of anastomotic stricture, tacrolimus-eluting biodegradable nanofiber was placed around the end-to-end anastomosis of abdominal aorta in rats. Five rats were allocated to the following 5 groups: ( 1) control without tacrolimus-eluting biodegradable nanofiber, ( 2) 5 mg of nanofiber only ( 0 wt% of tacrolimus), ( 3) 5 mg of tacrolimus-eluting biodegradable nanofiber containing 0.04 wt% of tacrolimus, ( 4) 5 mg of tacrolimus-eluting biodegradable nanofiber containing 0.1 wt% of tacrolimus, and ( 5) 5 mg of tacrolimus-eluting biodegradable nanofiber containing 1.0 wt% of tacrolimus. Morphometric and histologic analyses including immunohistochemistry were performed in each of the groups 2 weeks after the operation.
    Results: The tacrolimus-eluting biodegradable nanofiber gradually released tacrolimus for at least 1 month in vitro and in vivo. The ratio of intimal area was significantly reduced in the 1.0 wt% tacrolimus-eluting biodegradable nanofiber group compared with the other groups (0.26, 0.24, 0.25, 0.21, and 0.08 in control, 0 wt%, 0.04 wt%, 0.1 wt%, and 1.0 wt%, respectively, P <. 05). The cells, which constitute intimal hyperplasia, were positive for smooth muscle actin and SMemb, and factor VIII revealed that endothelial cells covered the surface of the aortic lumen even in the 1.0 wt% tacrolimus-eluting biodegradable nanofiber group in immunohistochemistry.
    Conclusion: Tacrolimus-eluting biodegradable nanofiber reduced neointimal hyperplasia and preserved endothelialization. This device may be useful in the prevention of anastomotic stricture.

    DOI: 10.1016/j.jtcvs.2008.11.017

    Web of Science

    PubMed

  80. Acute occlusion of left coronary ostium associated with congenital quadricuspid aortic valve Reviewed

    M Mutsuga, S Tamaki, Y Yokoyama, N Kato, J Yokote, N Ohata

    ANNALS OF THORACIC SURGERY   Vol. 79 ( 5 ) page: 1760 - 1   2005.5

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    Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    A 10-year-old girl suffered from chest discomfort during exercise. She experienced an acute myocardial infarction accompanied by an obstruction in an orifice to the left coronary artery. An emergency operation revealed that the aortic valve was quadricuspid, and a left-sided small cusp had adhered to the aortic wall resulting in an unusual sac with a tiny slit. Resection of the sac disclosed the ostium to left coronary artery. Blood toward the left coronary artery passed through the tiny slit. The mechanisms of obstruction in the coronary artery were uncertain. She recovered well after the aortic valve replacement with resection of the aortic cusps. (c) 2005 by The Society of Thoracic Surgeons.

    DOI: 10.1016/j.athoracsur.2003.11.052

    Web of Science

    PubMed

  81. Pseudoaneurysm from the Mitral-Aortic Intervalvular Fibrosa Following Endocarditis Reviewed

    Yukifusa Yokoyama, Shuji Tamaki, Noriyuki Kato, Jun Yokote, Masato Mutsuga

    Japanese Journal of Thoracic and Cardiovascular Surgery   Vol. 51 ( 8 ) page: 374 - 7   2003.8

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    Publishing type:Research paper (international conference proceedings)   Publisher:Japanese Association for Thoracic Surgery  

    A rare case of a pseudoaneurysm from the mitral-aortic intervalvular fibrosa following bacterial endocarditis in a 17-year-old male is presented. Destructive infection secondarily involved the mitral-aortic intervalvular fibrosa. Perforation of this portion resulted in the formation of the pseudoaneurysm situated at the base of the left ventricle between the aorta and the left atrium. With echocardiography, computed topography, angiography, and magnetic resonance imaging (MRI), a pseudoaneurysm was diagnosed. MRI especially revealed detailed information and the extension of pseudoaneurysm. Our patient underwent resection of the pseudoaneurysm, reconstruction of left ventricular outflow with glutaraldehyde-preserved bovine pericardium, and replacement of the aortic valve. His postoperative course was uneventful. No recurrence of endocarditis was detected in the following year.

    DOI: 10.1007/BF02719470

    Scopus

    PubMed

  82. Right atrial myxoma associated with atrial septal defect: a case report and review of the literature Reviewed

    H Murayama, S Tamaki, N Kato, N Yuji, J Yokote, M Mutsuga, M Okada

    Ann Thorac Cardiovasc Surg   Vol. 7 ( 3 ) page: 166 - 169   2001.6

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    Language:English   Publishing type:Research paper (scientific journal)  

  83. Repair of intercostal arteries in thoracoabdominal aneurysm Reviewed

    Y. Yokoyama, S. Tamaki, M. Ito, N. Kato, J. Yokote, M. Mutsuga, M. Okada

    Asian Cardiovascular and Thoracic Annals   Vol. 9 ( 3 ) page: 221 - 222   2001

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Asia Publishing Exchange Pte Ltd  

    A parallel aortic graft composed of a 20-mm graft with two 10-mm accessory grafts was used in the repair of a large thoracoabdominal aneurysm in a 50-year-old man. The graft was attached to 6 intercostal arteries and used immediately for spinal cord perfusion before repairing the aneurysm. The patient recovered quickly without paraplegia.

    DOI: 10.1177/021849230100900315

    Scopus

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Presentations 1

  1. Which is better procedure, using the frozen elephant trunk technique or the classical elephant trunk technique followed with the second stage TEVAR for extensive aortic arch repair?

    The 68th Annual Scientific Meeting of the Japanese Association for Thoracic Surgery 

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    Event date: 2015.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

KAKENHI (Grants-in-Aid for Scientific Research) 9

  1. 感染を予防・制御する抗菌性ポリマー人工血管の創出

    Grant number:22K08954  2022.4 - 2025.3

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    Authorship:Principal investigator 

    Grant amount:\4160000

  2. 経カテーテル僧帽弁置換のための安定した経心房中隔アクセス法の確立

    Grant number:22K08955  2022.4 - 2025.3

  3. 生体タンパク模倣短鎖ペプチドの創成と低侵襲的大動脈瘤治療法開発の試み

    Grant number:22H03155  2022.4 - 2025.3

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    Authorship:Coinvestigator(s) 

  4. Developing the device with biocompatible shape memory polymer for closing the entry of chronic type B aortic dissection

    Grant number:15K10239  2015.4 - 2019.3

    Mutsuga Masato

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    Authorship:Principal investigator 

    Grant amount:\4940000 ( Direct Cost: \3800000 、 Indirect Cost:\1140000 )

    The purpose of this study was to develop the device which is biocompatible and shape memory made by poly caprolactone capable of entry closure for chronic type B aortic dissection.The final destination was clinical application. Using the poly (e-caprolactone) (PCL) derivative prepared in the same way as last year in 2018, we will try to establish the in-vitro and in-vivo experimental system, and examine the usefulness of the developed carrier. It was difficult to develop an ideal biocompatible shape memory polymer and could not be completed. Therefore, The plan for the large animal aortic model was not able to be set up, and the in-vitro experimental system was not created, and the in-vivo experiment with the large animal was completed without any success.

  5. Development of Catheter therapy for ventricular sqptal perforation

    Grant number:23592033  2011 - 2013

    USUI Akihiko

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    Authorship:Coinvestigator(s) 

    We developed a catheter therapy for ventricular septum perforation (VSP) by using a stent-graft placed in the left ventricle. we adapt a net type stent which is knitted by a Nytinol thread. As an initial model, we made a cone-shaped stent-graft but it did not fit with papillary muscles. We changed the design of the stent-graft as a dissymmetry. It covered only with the septum but a pressure power of the septum side particularly the septum base side was weak even with the improved model.We made delivery sheath for direct insertion via the apex and developed an insertion method by using peal off system. We insert a stent-graft into a rubber heart model by using this delivery system. The stent graft can be inserted via the left ventricle apex and has it as a design preserving the directionality by fixing it in the apex. The design decision of the stent-graft which does not affect cardiac function is difficult and remains in the completion of a trial

  6. 総肺静脈還流異常症術後、肺静脈閉塞を予防する生体吸収性薬剤 溶出ナノファイバーの開発

    2008.4 - 2009.3

    公益財団法人 宮田心臓病研究振興基金  医学研究者の学究等に対する奨励金 

    六鹿 雅登

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    Authorship:Principal investigator  Grant type:Competitive

  7. Development of method for cardiovascular tissue engineering-Importance of median smooth muscle layer-

    Grant number:19790970  2007 - 2008

    MUTSUGA Masato

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    Authorship:Principal investigator 

    Grant amount:\3690000 ( Direct Cost: \3300000 、 Indirect Cost:\390000 )

  8. M2マクロファージによる効率的大動脈瘤治療法の確立

    Grant number:22K08933 

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    Authorship:Coinvestigator(s) 

  9. 大動脈瘤におけるマクロファージAIM炎症機構の解明と治療法の開発

    Grant number:22K08932 

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Industrial property rights 1

  1. The Material and Method to develop “Cotton Wool” manufacture for Cardiac therapy

    MUTSUGA Masato

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    Application no:特願2008-111236  Date applied:2008.4

 

Teaching Experience (On-campus) 3

  1. 先天性心疾患

    2021

  2. 人工心臓

    2021

  3. 心臓移植

    2021

 

Social Contribution 1

  1. Tsrumai Open Presentation

    Role(s):Lecturer

    Nagoya University Graduate School of Medicine  2018.12