Updated on 2024/09/19

写真a

 
KIMURA Kouji
 
Organization
Graduate School of Medicine Program in Integrated Medicine Microbiology and Immunology Associate professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Associate professor
Contact information
メールアドレス

Degree 1

  1. 医学博士 ( 2004.7   京都大学 ) 

Research Interests 1

  1. 薬剤耐性菌 PRGBS ペニシリン低感受性B群連鎖球菌

Research Areas 1

  1. Others / Others  / 感染症学

Research History 9

  1. 名古屋大学大学院医学系研究科 准教授

    2016.4

      More details

    Country:Japan

  2. 名古屋大学大学院医学系研究科 講師

    2012.4 - 2016.3

      More details

    Country:Japan

  3. 名古屋大学大学院医学系研究科 助教

    2011.7 - 2012.3

      More details

    Country:Japan

  4. 国立感染症研究所細菌第二部 主任研究官

    2009.2 - 2011.6

      More details

    Country:Japan

  5. 国立感染症研究所流動研究員

    2006.10 - 2009.1

      More details

    Country:Japan

  6. 国立感染症研究所臨時職員

    2005.4 - 2006.9

      More details

    Country:Japan

  7. 国立感染症研究所流動研究員

    2004.4 - 2005.3

      More details

    Country:Japan

  8. 京都大学大学院医学研究科研修員

    2002.4 - 2004.3

      More details

    Country:Japan

  9. 日本学術振興会特別研究員(DC1)

    1999.4 - 2002.3

      More details

    Country:Japan

▼display all

Education 3

  1. Kyoto University   Graduate School, Division of Medical Sciences

    - 2002.3

      More details

    Country: Japan

  2. Nagoya University   Faculty of Medicine

    1992.4 - 1998.3

      More details

    Country: Japan

  3. 高田高校(三重県)   6年制

    - 1992.3

      More details

    Country: Japan

Professional Memberships 11

  1. 日本細菌学会   会員

    2006.1

  2. 日本細菌学会   Infection Control Doctor

    2015.1

  3. 日本細菌学会   中部支部評議員

    2016.10

  4. 日本臨床微生物学会   会員

    2007.10

  5. 日本臨床微生物学会   評議員

    2013.2

  6. 日本感染症学会   会員

    2006.10

  7. 日本化学療法学会   会員

    2006.12

  8. 日本小児感染症学会   会員

    2007.7

  9. 日本周産期・新生児医学会   会員

    2010.2

  10. American Society for Microbiology   Contributing member

    2005.9

  11. The Lancefield Society   Standard member

    2022.3

▼display all

Awards 3

  1. 黒屋奨学賞

    2014.3   日本細菌学会  

     More details

    Country:Japan

  2. 第13回日本抗生物質学術協議会奨励賞

    2011   日本抗生物質学術協議会  

     More details

    Country:Japan

  3. 第20回上田泰記念感染症・化学療法研究奨励賞

    2008   日本化学療法学会  

     More details

    Country:Japan

 

Papers 76

  1. β-Lactam Susceptibility of Streptococcus dysgalactiae subsp. equisimilis.

    Nakashima N, Jin W, Wachino JI, Koyama S, Tamai K, Arakawa Y, Kimura K

    Japanese journal of infectious diseases   Vol. 77 ( 4 ) page: 236 - 239   2024.7

     More details

    Language:English  

    DOI: 10.7883/yoken.JJID.2023.339

    PubMed

  2. Clinical isolates of <i>Streptococcus mitis/oralis</i>-related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan

    Sarangi, J; Ido, A; Ito, M; Iinuma, C; Doyama, Y; Jin, WC; Wachino, JI; Suzuki, M; Iguchi, M; Yagi, T; Arakawa, Y; Kimura, K

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   Vol. 68 ( 4 ) page: e0117923   2024.4

     More details

  3. Hydroxyhexylitaconic acids as potent IMP-type metallo-β-lactamase inhibitors for controlling carbapenem resistance in <i>Enterobacterales</i>

    Wachino, J; Jin, WC; Norizuki, C; Kimura, K; Tsuji, M; Kurosaki, H; Arakawa, Y

    MICROBIOLOGY SPECTRUM   Vol. 12 ( 3 ) page: e0234423   2024.3

     More details

  4. Improved disk diffusion method for simple detection of group B streptococci with reduced penicillin susceptibility (PRGBS)

    Goto, R; Jin, WC; Wachino, JI; Arakawa, Y; Kimura, K

    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE   Vol. 105 ( 3 ) page: 115881   2023.3

     More details

  5. Bird's-eye MApping of plasmids (BeMAp) for visualization and comparison of genomic structures of different plasmids by mapping antimicrobial resistance genes on spreadsheets

    Tsuda, Y; Suzuki, M; Wachino, JI; Kimura, K; Arakawa, Y

    JOURNAL OF MICROBIOLOGICAL METHODS   Vol. 204   page: 106645   2023.1

     More details

  6. Genomic Traits Associated with Virulence and Antimicrobial Resistance of Invasive Group B Streptococcus Isolates with Reduced Penicillin Susceptibility from Elderly Adults Reviewed

    Koide, S; Nagano, Y; Takizawa, S; Sakaguchi, K; Soga, E; Hayashi, W; Tanabe, M; Denda, T; Kimura, K; Arakawa, Y; Nagano, N

    MICROBIOLOGY SPECTRUM   Vol. 10 ( 3 ) page: e0056822   2022.6

     More details

  7. Dissecting the clonality of I1 plasmids using ORF-based binarized structure network analysis of plasmids (OSNAp) Reviewed

    Suzuki, M; Norizuki, C; Wachino, J; Kawamura, K; Nagano, N; Nagano, Y; Hayashi, W; Kimura, K; Doi, Y; Arakawa, Y

    JOURNAL OF INFECTION AND CHEMOTHERAPY   Vol. 28 ( 4 ) page: 473 - 479   2022.4

     More details

  8. Molecular Epidemiology of <i>Enterobacter cloacae</i> Complex Isolates with Reduced Carbapenem Susceptibility Recovered by Blood Culture Reviewed

    Sarangi, J; Matsuo, N; Nonogaki, R; Hayashi, M; Kawamura, K; Suzuki, M; Jin, WC; Tamai, K; Ogawa, M; Wachino, J; Kimura, K; Yagi, T; Arakawa, Y

    JAPANESE JOURNAL OF INFECTIOUS DISEASES   Vol. 75 ( 1 ) page: 41 - 48   2022.1

     More details

  9. Isolation of Group A Streptococci with Reduced <i>In Vitro</i> β-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan Reviewed

    Ikeda, T; Suzuki, R; Jin, WC; Wachino, JI; Arakawa, Y; Kimura, K

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   Vol. 65 ( 12 ) page: e0148221   2021.11

     More details

  10. Practical Agar-Based Disk Diffusion Tests Using Sulfamoyl Heteroarylcarboxylic Acids for Identification of Subclass B1 Metallo-β-Lactamase-Producing <i>Enterobacterales</i> Reviewed

    Norizuki, C; Wachino, J; Jin, WC; Kimura, K; Kawamura, K; Nagano, N; Arakawa, Y

    JOURNAL OF CLINICAL MICROBIOLOGY   Vol. 59 ( 10 ) page: e0076121   2021.10

     More details

  11. Daptomycin Susceptibility of Group B <i>Streptococcus</i> Reviewed

    Ushino, T; Jin, W; Wachino, JI; Arakawa, Y; Kimura, K

    JAPANESE JOURNAL OF INFECTIOUS DISEASES   Vol. 74 ( 3 ) page: 233 - 235   2021.5

     More details

  12. Sulfamoyl Heteroarylcarboxylic Acids as Promising Metallo-β-Lactamase Inhibitors for Controlling Bacterial Carbapenem Resistance Reviewed

    Wachino, J; Jin, WC; Kimura, K; Kurosaki, H; Sato, A; Arakawa, Y

    MBIO   Vol. 11 ( 2 )   2020.3

     More details

  13. Erythromycin-Susceptible but Clindamycin-Resistant Phenotype of Clinical ermB-PCR-Positive Group B Streptococci Isolates with IS1216E-Inserted ermB. Reviewed International coauthorship

    Moroi H, Kimura K, Ido A, Banno H, Jin W, Wachino JI, Yamada K, Kikkawa F, Park YJ, Arakawa Y

    Japanese journal of infectious diseases   Vol. 72 ( 6 ) page: 420 - 422   2019.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.7883/yoken.JJID.2019.015

    Web of Science

    PubMed

  14. 4-Amino-2-Sulfanylbenzoic Acid as a Potent Subclass B3 Metallo-beta-Lactamase-Specific Inhibitor Applicable for Distinguishing Metallo-beta-Lactamase Subclasses Reviewed

    Wachino Jun-ichi, Kanechi Reo, Nishino Erina, Mochizuki Marie, Jin Wanchun, Kimura Kouji, Kurosaki Hiromasa, Arakawa Yoshichika

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   Vol. 63 ( 10 )   2019.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/AAC.01197-19

    Web of Science

    PubMed

  15. Intercellular Transfer of Chromosomal Antimicrobial Resistance Genes between Acinetobacter baumannii Strains Mediated by Prophages Reviewed

    Wachino Jun-ichi, Jin Wanchun, Kimura Kouji, Arakawa Yoshichika

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   Vol. 63 ( 8 )   2019.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/AAC.00334-19

    Web of Science

    PubMed

  16. Spread of seb-Positive Methicillin-Resistant Staphylococcus aureus SCCmec Type II-ST764 Among Elderly Japanese in Nonacute Care Settings Reviewed

    Kawamura Kumiko, Kitaoka Kazuki, Kimura Kouji, Wachino Jun-ichi, Kondo Takaaki, Iinuma Yoshitsugu, Murakami Nobuo, Fujimoto Shuhei, Arakawa Yoshichika

    MICROBIAL DRUG RESISTANCE   Vol. 25 ( 6 ) page: 915 - 924   2019.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/mdr.2018.0337

    Web of Science

    PubMed

  17. First Case in Korea of Group B Streptococcus With Reduced Penicillin Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Protein 2X Reviewed International coauthorship

    Yi Ahram, Kim Chang-Ki, Kimura Kouji, Arakawa Yoshichika, Hur Mina, Yun Yeo-Min, Moon Hee-Won

    ANNALS OF LABORATORY MEDICINE   Vol. 39 ( 4 ) page: 414 - 416   2019.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3343/alm.2019.39.4.414

    Web of Science

    PubMed

  18. Relatively high rates of cefotaxime- and ceftriaxone-non-susceptible isolates among group B streptococci with reduced penicillin susceptibility (PRGBS) in Japan Reviewed

    Kitamura Masaki, Kimura Kouji, Ido Ayaka, Seki Tomomi, Banno Hirotsugu, Jin Wanchun, Wachino Jun-ichi, Yamada Keiko, Arakawa Yoshichika

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY   Vol. 74 ( 4 ) page: 931 - 934   2019.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jac/dky542

    Web of Science

    PubMed

  19. Population-level transition of capsular polysaccharide types among sequence type 1 group B Streptococcus isolates with reduced penicillin susceptibility during a long-term hospital epidemic Reviewed

    Nagano Noriyuki, Koide Shota, Hayashi Wataru, Taniguchi Yui, Tanaka Hayato, Maeyama Yoshihiko, Suzuki Masahiro, Kimura Kouji, Arakawa Yoshichika, Nagano Yukiko

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS   Vol. 53 ( 3 ) page: 203 - 210   2019.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijantimicag.2018.11.003

    Web of Science

    PubMed

  20. Potential effect of selective pressure with different beta-lactam molecules on the emergence of reduced susceptibility to beta-lactams in group B Streptococci Reviewed

    Koide Shota, Hayashi Wataru, Taniguchi Yui, Tanaka Hayato, Kimura Kouji, Nagano Yukiko, Arakawa Yoshichika, Nagano Noriyuki

    MICROBIOLOGY AND IMMUNOLOGY   Vol. 63 ( 2 ) page: 65 - 76   2019.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1348-0421.12667

    Web of Science

    PubMed

  21. Isolation of group B Streptococcus with reduced beta-lactam susceptibility from pregnant women Reviewed

    Moroi Hiroaki, Kimura Kouji, Kotani Tomomi, Tsuda Hiroyuki, Banno Hirotsugu, Jin Wanchun, Wachino Jun-ichi, Yamada Keiko, Mitsui Takashi, Yamashita Mamoru, Kikkawa Fumitaka, Arakawa Yoshichika

    EMERGING MICROBES & INFECTIONS   Vol. 8 ( 1 ) page: 2 - 7   2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/22221751.2018.1557987

    Web of Science

    PubMed

  22. Prevalence of CTX-M-Type Extended-Spectrum -Lactamase-Producing Escherichia coli B2-O25-ST131 H30R Among Residents in Nonacute Care Facilities in Japan Reviewed

    Kawamura Kumiko, Hayashi Kengo, Matsuo Nao, Kitaoka Kazuki, Kimura Kouji, Wachino Jun-ichi, Kondo Takaaki, Iinuma Yoshitsugu, Murakami Nobuo, Fujimoto Shuhei, Arakawa Yoshichika

    MICROBIAL DRUG RESISTANCE   Vol. 24 ( 10 ) page: 1513 - 1520   2018.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/mdr.2018.0068

    Web of Science

    PubMed

  23. High prevalence of bla(CTX-M-14) among genetically diverse Escherichia coli recovered from retail raw chicken meat portions in Japan Reviewed

    Hayashi Wataru, Ohsaki Yusuke, Taniguchi Yui, Koide Shota, Kawamura Kumiko, Suzuki Masahiro, Kimura Kouji, Wachino Jun-ichi, Nagano Yukiko, Arakawa Yoshichika, Nagano Noriyuki

    INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY   Vol. 284   page: 98 - 104   2018.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijfoodmicro.2018.08.003

    Web of Science

    PubMed

  24. A nationwide population-based surveillance of invasive Haemophilus influenzae diseases in children after the introduction of the Haemophilus influenzae type b vaccine in Japan. Reviewed

    Suga S, Ishiwada N, Sasaki Y, Akeda H, Nishi J, Okada K, Fujieda M, Oda M, Asada K, Nakano T, Saitoh A, Hosoya M, Togashi T, Matsuoka M, Kimura K, Shibayama K

    Vaccine   Vol. 36 ( 38 ) page: 5678 - 5684   2018.9

     More details

    Language:English  

    DOI: 10.1016/j.vaccine.2018.08.029

    PubMed

  25. Carbapenem-Nonsusceptible <i>Haemophilus influenzae</i> with Penicillin-Binding Protein 3 Containing an Amino Acid Insertion Reviewed

    Kitaoka, K; Kimura, K; Kitanaka, H; Banno, H; Jin, W; Wachino, J; Arakawa, Y

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   Vol. 62 ( 8 )   2018.8

     More details

  26. High isolation rate and multidrug resistance tendency of penicillin-susceptible group B <i>Streptococcus</i> with reduced ceftibuten susceptibility in Japan Reviewed

    Banno, H; Kimura, K; Seki, T; Jin, WC; Wachino, J; Yamada, K; Nagano, N; Arakawa, Y

    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES   Vol. 37 ( 8 ) page: 1511 - 1519   2018.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10096-018-3278-7

    Web of Science

    PubMed

  27. Predominance of Serogroup 19 CC320/271 among Penicillin-Nonsusceptible Streptococcus pneumoniae Isolates after Introduction of the PCV7 Vaccine in Several Regions of Japan Reviewed

    Oodate Mitsuru, Kimura Kouji, Banno Hirotsugu, Yokoyama Satoru, Jin Wanchun, Wachino Jun-ichi, Hasegawa Yoshinori, Arakawa Yoshichika

    JAPANESE JOURNAL OF INFECTIOUS DISEASES   Vol. 71 ( 1 ) page: 14 - 20   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.7883/yoken.JJID.2017.236

    Web of Science

    PubMed

  28. Structural Insights into the TLA-3 Extended-Spectrum beta-Lactamase and Its Inhibition by Avibactarn and OP0595 Reviewed

    Jin Wanchun, Wachino Jun-ichi, Yamaguchi Yoshihiro, Kimura Kouji, Kumar Anupriya, Yamada Mototsugu, Morinaka Akihiro, Sakamaki Yoshiaki, Yonezawa Minoru, Kurosaki Hiromasa, Arakawa Yoshichika

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   Vol. 61 ( 10 )   2017.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/AAC.00501-17

    Web of Science

    PubMed

  29. Analysis of multidrug resistant group B streptococci with reduced penicillin susceptibility forming small, less hemolytic colonies Reviewed

    Banno Hirotsugu, Kimura Kouji, Tanaka Yosuke, Sekizuka Tsuyoshi, Kuroda Makoto, Jin Wanchun, Wachino Jun-ichi, Yamada Keiko, Shibayama Keigo, Arakawa Yoshichika

    PLOS ONE   Vol. 12 ( 8 ) page: e0183453   2017.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0183453

    Web of Science

    PubMed

  30. Specific bla(CTX-M-8)/IncI1 Plasmid Transfer among Genetically Diverse Escherichia coli Isolates between Humans and Chickens Reviewed

    Norizuki Chihiro, Wachino Jun-ichi, Suzuki Masahiro, Kawamura Kumiko, Nagano Noriyuki, Kimura Kouji, Arakawa Yoshichika

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   Vol. 61 ( 6 )   2017.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/AAC.00663-17

    Web of Science

    PubMed

  31. High rate of slowly-killed-by-ampicillin phenotype among group B streptococci with reduced penicillin susceptibility Reviewed

    Taniguchi Rina, Kimura Kouji, Miyazaki Akira, Banno Hirotsugu, Jin Wanchun, Yamada Keiko, Wachino Jun-ichi, Arakawa Yoshichika

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY   Vol. 72 ( 3 ) page: 941 - 942   2017.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jac/dkw500

    Web of Science

    PubMed

  32. Structural insights into recognition of hydrolyzed carbapenems and inhibitors by subclass B3 metallo-β-lactamase SMB-1 Reviewed

    J. Wachino, Y. Yamaguchi, S. Mori, W. Jin, K. Kimura, H. Kurosaki, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 60 ( 7 ) page: 4274-82   2016

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  33. A highly macrolide-resistant Campylobacter jejuni strain with rare A2074T mutations in 23S rRNA genes Reviewed

    H. Ohno, J. Wachino, R. Saito, W. Jin, K. Yamada, K. Kimura, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 60 ( 4 ) page: 2580-1   2016

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  34. Effectual detection of group B streptococci with reduced penicillin susceptibility (PRGBS) by commercially available methicillin-resistant-Staphylococcus aureus (MRSA)-selective agar Reviewed

    S. Fukigai¶, M. Morimoto¶, K. Kimura*, Y. Doyama, A. Miyazaki, C. Kamiya, H. Banno, E. Morishima, T. Onoda, N. Nagano, W. Jin, J. Wachino, K. Yamada, Y. Arakawa

    Diagnostic Microbiology and Infectious Disease   Vol. 85 ( 3 ) page: 309-12   2016

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  35. In vitro reduction of antibacterial activity of tigecycline against multidrug-resistant Acinetobacter baumannii with host stress hormone norepinephrine Reviewed

    M. Inaba, N. Matsuda, H. Banno, W. Jin, J. Wachino, K. Yamada, K. Kimura, Y. Arakawa

    International Journal of Antimicrobial Agents     page: in press   2016

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  36. Comparative Analysis of Penicillin-Susceptible and Non-Susceptible Isolates in Group B Streptococci by Multilocus Sequence Typing Reviewed

    R. Yamada, K. Kimura*, N. Nagano, Y. Nagano, S. Suzuki, W. Jin, J. Wachino, K. Yamada, K. Shibayama, Y. Arakawa

    Japanese Journal of Infectious Diseases   Vol. 68 ( 4 ) page: 326-329   2015

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  37. Genetic Profiles of Fluoroquinolone-Nonsusceptible Klebsiella pneumoniae Among Cephalosporin-Resistant K. pneumoniae Reviewed

    Y. Nagasaka, K. Kimura, K. Yamada, J. Wachino, W. Jin, S. Notake, H. Yanagisawa, Y. Arakawa

    Microbial Drug Resistance   Vol. 21 ( 2 ) page: 224-33   2015

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  38. Have Group A Streptococci with Reduced Penicillin Susceptibility Emerged? Reviewed

    T. Suzuki, K. Kimura*, H. Suzuki, H. Banno, W. Jin, J. Wachino, K. Yamada, Y. Arakawa

    The Journal of Antimicrobial Chemotherapy   Vol. 70 ( 4 ) page: 1258-9   2015

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  39. New Plasmid-Mediated Aminoglycoside 6'-N-Acetyltransferase, AAC(6')-Ian, and Extended-Spectrum β-Lactamase, TLA-3, from Serratia marcescens Clinical Isolate Reviewed

    W. Jin, J. Wachino, K. Kimura, K. Yamada, Y. Arakawa

    The Journal of Antimicrobial Chemotherapy   Vol. 70 ( 5 ) page: 1331-7   2015

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  40. Classification of Group B Streptococci with Reduced β-Lactam Susceptibility (GBS-RBS) Based on the Amino Acid Substitutions in Penicillin-binding Proteins (PBPs) Reviewed

    K. Kimura*, N. Nagano, Y. Arakawa

    The Journal of Antimicrobial Chemotherapy   Vol. 70 ( 6 ) page: 1601-1603   2015

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  41. Molecular Epidemiological Characteristics of Klebsiella pneumoniae Associated with Bacteremia among Patients with Pneumonia Reviewed

    R. Ito, Y. Shindo, D. Kobayashi, M. Ando, W. Jin, J. Wachino, K. Yamada, K. Kimura, T. Yagi, Y. Hasegawa, Y. Arakawa

    Journal Clinical Microbiology   Vol. 53 ( 3 ) page: 879-86   2015

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  42. Ceftibuten-Containing Agar Plate for Detecting Group B Streptococci with Reduced Penicillin Susceptibility (PRGBS) Reviewed

    C. Kamiya, K. Kimura*, Y. Doyama, A. Miyazaki, M. Morimoto, H. Banno, N. Nagano, W. Jin, J. Wachino, K. Yamada, Y. Arakawa

    Diagnostic Microbiology and Infectious Disease   Vol. 82 ( 4 ) page: 269-273   2015

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  43. High isolation rate of multi-drug resistant group B streptococci with reduced penicillin susceptibility in Japan Reviewed

    T. Seki, K. Kimura*, M. E. Reid, A. Miyazaki, H. Banno, W. Jin, J. Wachino, K. Yamada, Y. Arakawa

    The Journal of Antimicrobial Chemotherapy   Vol. 70 ( 10 ) page: 2725-2728   2015

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  44. Characterization of piperacillin/tazobactam-resistant Klebsiella oxytoca recovered from a nosocomial outbreak Reviewed

    A. Fujita, K. Kimura*, S. Yokoyama, W. Jin, J. Wachino, K. Yamada, H. Suematsu, Y. Yamagishi, H. Mikamo, Y. Arakawa

    PLOS ONE   Vol. 10 ( 11 ) page: e0142366   2015

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  45. Characterization of Multi-drug-Resistant Group B Streptococci with Reduced Penicillin Susceptibility (PRGBS) Forming Small Non-β-hemolytic Colonies on Sheep Blood Agar Plates Reviewed

    H. Banno, K. Kimura*, Y. Tanaka, H. Kitanaka, W. Jin, J. Wachino, K. Yamada, K. Shibayama, Y. Arakawa

    Journal Clinical Microbiology   Vol. 52 ( 6 ) page: 2169-71   2014

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  46. Novel integron-mediated fosfomycin-resistance genetic determinant, fosK Reviewed

    H. Kitanaka, J. Wachino, W. Jin, S. Yokoyama, M. Sasano, M. Hori, K. Yamada, K. Kimura, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 58 ( 8 ) page: 4978-9   2014

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  47. Carbapenem-resistant Acinetobacter soli as a newly emerging invasive pathogen Reviewed

    H. Kitanaka, M. Sasano, S. Yokoyama, M. Suzuki, W. Jin, M. Inayoshi, M. Hori, J. Wachino, K. Kimura, K. Yamada, Y. Arakawa

    Emerging Infectious Disease   Vol. 20 ( 9 ) page: 1574-6   2014

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  48. Practical Agar-Based Disk Potentiation Test to Detect Fosfomycin-Non-Susceptible Escherichia coli Clinical Isolates Producing Glutathione S-Transferases. Reviewed

    G. Nakamura, J. Wachino, N. Sato, K. Kimura, K. Yamada, W. Jin, K. Shibayama, T. Yagi, K. Kawamura, Y. Arakawa

    Journal Clinical Microbiology   Vol. 52 ( 9 ) page: 3175-9   2014

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  49. Penicillin-susceptible group B streptococcal clinical isolates with reduced cephalosporin susceptibility Reviewed

    N. Nagano, Y. Nagano, M. Toyama, K. Kimura, K. Shibayama, Y. Arakawa

    Journal Clinical Microbiology   Vol. 52 ( 9 ) page: 3406-10   2014

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  50. Evaluation of Disk Potentiation Test Using KB Disks Containing High Dosage Fosfomycin and Glucose-6-Phosphate to Detect the Production of Glutathione S-Transferase Responsible For Fosfomycin Resistance Reviewed

    J. Wachino, K. Kimura, K. Yamada, W. Jin, Y. Arakawa

    Journal Clinical Microbiology   Vol. 52 ( 10 ) page: 3827-8   2014

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  51. The incidence of pediatric invasive Haemophilus influenzae and pneumococcal disease in Chiba prefecture, Japan before and after the introduction of conjugate vaccines Reviewed

    N Ishiwada, H Hishiki, K Nagasawa, S Naito, Y Sato, B Chang, Y Sasaki, K Kimura, M Ohnishi, K Shibayama

    Vaccine   Vol. 32 ( 42 ) page: 5425-31   2014

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  52. Screening for Group B Streptococci with Reduced Penicillin Susceptibility (PRGBS) in Clinical Isolates Obtained between 1977 and 2005 Reviewed

    K. Kimura, Y. Nishiyama, S. Shimizu, J. Wachino, M. Matsui, S. Suzuki, K. Yamane, K. Shibayama, Y. Arakawa

    Japanese Journal of Infectious Diseases   Vol. 66 ( 3 ) page: 222-225   2013

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  53. Rapid and reliable loop-mediated isothermal amplification method for detecting Streptococcus agalactiae Reviewed

    K. Kimura, H. Yanagisawa, J. Wachino, K. Shibayama, Y. Arakawa

    Japanese Journal of Infectious Diseases   Vol. 66   page: 546-548   2013

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  54. High Frequency of Fluoroquinolone- and Macrolide-resistant Streptococci among Clinically Isolated Group B Streptococci with Reduced Penicillin Susceptibility Reviewed

    K. Kimura, N. Nagano, Y. Nagano, S. Suzuki, J. Wachino, K. Shibayama, Y. Arakawa

    The Journal of Antimicrobial Chemotherapy   Vol. 68 ( 3 ) page: 539-42   2013

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  55. Ability of the VITEK® 2 System to Detect Group B Streptococci with Reduced Penicillin Susceptibility (PRGBS) Reviewed

    K. Kimura, N. Nagano, Y. Nagano, J. Wachino, K. Shibayama, Y. Arakawa

    The Journal of Antimicrobial Chemotherapy   Vol. 68 ( 6 ) page: 1442-4   2013

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  56. Active Screening of Group B Streptococci with Reduced Penicillin Susceptibility and Altered Serotype Distribution, Isolated from Pregnant Women in Kobe, Japan Reviewed

    K. Kimura, K. Matsubara, G. Yamamoto, K. Shibayama, Y. Arakawa

    Japanese Journal of Infectious Diseases   Vol. 66 ( 2 ) page: 158-60   2013

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  57. High cephalosporin resistance due to amino acid substitutions in PBP1A and PBP2X in a clinical isolate of group B streptococcus Reviewed

    K. Kimura, J. Wachino, H. Kurokawa, M. Matsui, S. Suzuki, K. Yamane, N. Nagano, K. Shibayama, Y. Arakawa

    The Journal of Antimicrobial Chemotherapy   Vol. 68 ( 7 ) page: 1533-1536   2013

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  58. Nosocomial spread of multidrug-resistant group B streptococci with reduced penicillin susceptibility belonging to clonal complex 1 Reviewed

    N. Nagano, Y. Nagano, M. Toyama, K. Kimura, T. Tamura, K. Shibayama, Y. Arakawa

    The Journal of Antimicrobial Chemotherapy   Vol. 67 ( 4 ) page: 849-856   2012

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  59. Predominance of sequence type 1 group with serotype VI among group B atreptococci with reduced penicillin susceptibility identified in Japan Reviewed

    K. Kimura, N. Nagano, Y. Nagano, J. Wachino, S. Suzuki, K. Shibayama, Y. Arakawa

    The Journal of Antimicrobial Chemotherapy   Vol. 66   page: 2460-2464   2011

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  60. RmtC introduces G1405 methylation in 16S rRNA and confers high-level aminoglycoside resistance on Gram-positive microorganisms Reviewed

    J. Wachino, K. Shibayama, K. Kimura, K. Yamane, S. Suzuki, Y. Arakawa

    FEMS Microbiol Lett   Vol. 311 ( 1 ) page: 56-60   2010

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  61. Prevalence of Fosfomycin Resistance among CTX-M-Producing Escherichia coli Clinical Isolates in Japan and Identification of Novel Plasmid-Mediated Fosfomycin-Modifying Enzymes Reviewed

    J. Wachino, K. Yamane, S. Suzuki, K. Kimura, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 54 ( 7 ) page: 3061-3064   2010

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  62. Molecular characterization of group B streptococci with reduced penicillin susceptibility recurrently isolated from a sacral decubitus ulcer Reviewed

    N. Nagano, K. Kimura, Y. Nagano, H. Yakumaru, Y. Arakawa

    The Journal of Antimicrobial Chemotherapy   Vol. 64 ( 6 ) page: 1326-1328   2009

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  63. Practical disk diffusion test for detecting group B streptococcus with reduced penicillin susceptibility Reviewed

    K. Kimura, J. Wachino, H. Kurokawa, S. Suzuki, K. Yamane, N. Shibata, Y. Arakawa

    Journal Clinical Microbiology   Vol. 47 ( 12 ) page: 4154-4157   2009

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  64. First Molecular Characterization of Group B Streptococci with Reduced Penicillin Susceptibility Reviewed

    K. Kimura, S. Suzuki, J. Wachino, H. Kurokawa, K. Yamane, N. Shibata, N. Nagano, H. Kato, K. Shibayama,, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 52   page: 2890-2897   2008

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  65. Genetic heterogeneity in pbp genes among clinically isolated group B streptococci with reduced penicillin susceptibility Reviewed

    N. Nagano, Y. Nagano, K. Kimura, K. Tamai, H. Yanagisawa, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 52   page: 4258-4267   2008

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  66. New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate Reviewed

    K. Yamane, J. Wachino, S. Suzuki, K. Kimura, N. Shibata, H. Kato, K. Shibayama, T. Konda, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 51 ( 9 ) page: 3354-336   2007

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  67. Novel Plasmid-Mediated 16S rRNA m1A1408 Methyltransferase, NpmA, Found in a Clinically Isolated Escherichia coli Strain Resistant to Structurally Diverse Aminoglycosides Reviewed

    J. Wachino, K. Shibayama, H. Kurokawa, K. Kimura, K. Yamane, S. Suzuki, N. Shibata, Y. Ike, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 51 ( 12 ) page: 4401-4409   2007

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  68. 16S rRNA methylase-producing, gram-negative pathogens, Japan Reviewed

    K. Yamane, J. Wachino, S. Suzuki, N. Shibata, H. Kato, K. Shibayama, K. Kimura, K. Kai, S. Ishikawa, Y. Ozawa, T. Konda, Y. Arakawa

    Emerging Infectious Disease   Vol. 13 ( 4 ) page: 642-646   2007

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  69. PCR Classification of CTX-M Type beta-Lactamase Genes Identified In Clinically Isolated Gram-Negative Bacilli in Japan Reviewed

    N. Shibata, H. Kurokawa, Y. Doi, T. Yagi, K. Yamane, J. Wachino, S. Suzuki, K. Kimura, S. Ishikawa, H. Kato, Y. Ozawa, K. Shibayama, K. Kai, T. Konda, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 50   page: 791-795   2006

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  70. Mode of transposition and expression of 16S rRNA methyltransferase gene rmtC accompanied by ISEcp1 Reviewed

    J. Wachino, K. Yamane, K. Kimura N. Shibata, S. Suzuki Y. Ike Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 50   page: 3212-3215   2006

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  71. Novel Plasmid-Mediated 16S rRNA Methylase, RmtC, Found in Proteus mirabilis Demonstrating Extraordinary High-Level Resistance against Various Aminoglycoside Reviewed

    J. Wachino, K. Yamane, K. Shibayama, H. Kurokawa, N. Shibata, S. Suzuki, Y. Doi, K. Kimura, Y. Ike, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 50   page: 178-184   2006

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  72. Horizontal Transfer of blaCMY-Bearing Plasmids among Clinical Escherichia coli and Klebsiella pneumoniae Isolates, and Emergence of Cefepime-Hydrolyzing CMY-19 Reviewed

    J. Wachino, H. Kurokawa, S. Suzuki, K. Yamane, N. Shibata, K. Kimura, Y. Ike, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 50   page: 534-541   2006

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  73. Hyperpolarization-activated, cyclic nucleotide-gated HCN2 cation channel forms a protein assembly with multiple neuronal scaffold proteins in distinct modes of protein-protein interaction Reviewed

    K. Kimura, J. Kitano, Y. Nakajima, S. Nakanishi

    Genes to Cells   Vol. 9   page: 631-640   2004

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  74. Tamalin Is a Scaffold Protein That Interacts with Multiple Neuronal Proteins in Distinct Modes of Protein-Protein Association Reviewed

    J. Kitano, Y. Yamazaki, K. Kimura, T. Masukado, Y. Nakajima, S. Nakanishi

    The Journal of Biological Chemistry   Vol. 278   page: 14762-14768   2003

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  75. Tamalin, a PDZ Domain-Containing Protein, Links a Protein Complex Formation of Group 1 Metabotropic Glutamate Receptors and the Guanine Nucleotide Exchange Factor Cytohesins Reviewed

    J. Kitano, K. Kimura, Y. Yamazaki, T. Soda, R. Shigemoto, Y. Nakajima, S. Nakanishi

    The Journal of Neuroscience   Vol. 22   page: 1280-1289   2002

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  76. Molecular Aspects of High-Level Resistance to Sulbactam-Cefoperazone in Klebsiella oxytoca Clinical Isolates Reviewed

    K. Kimura, Y. Arakawa, S. Ohsuka, H. Ito, K. Suzuki, H. Kurokawa, N. Kato, M. Ohta

    Antimicrobial Agents and Chemotherapy   Vol. 40   page: 1988-1994   1996

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

▼display all

Presentations 15

  1. Multidrug resistance in group B Streptococcus Invited International conference

    Kouji Kimura

    The 21st Lancefield international symposium on streptococci and streptococcal diseases  2022.6.10  The Lancefield society

     More details

    Event date: 2022.6

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Stockholm   Country:Sweden  

  2. B群レンサ球菌

    木村幸司

    第90回日本感染症学会西日本地方会学術集会・第63回日本感染症学会中日本地方会学術集会・第68回日本化学療法学会西日本支部総会  2020.11.7 

     More details

    Event date: 2020.11

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡  

  3. レンサ球菌 Invited

    木村幸司

    第68回日本化学療法学会総会  2020.9.13 

     More details

    Event date: 2020.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:神戸  

  4. 細菌検査から始まる薬剤耐性研究

    木村幸司、黒川博史、長野則之、荒川宜親

    第94回日本感染症学会総会 

     More details

    Event date: 2020.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:東京   Country:Japan  

  5. β—ラクタム系薬低感受性B群レンサ球菌(GBS-RBS) Invited

    木村幸司、長野則之、荒川宜親

    第93回日本細菌学会総会 

     More details

    Event date: 2020.2

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:名古屋   Country:Japan  

  6. Group B Streptococcus with reduced beta-lactam susceptibility (GBS-RBS) Invited

    K. Kimura, N. Nagano, Y. Arakawa

     More details

    Event date: 2020.1 - 2020.2

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  7. PRGBSを含むβラクタム系薬低感受性B群レンサ球菌(GBS-RBS)に関する研究

    木村幸司、長野則之、荒川宜親

    第89回日本細菌学会総会 

     More details

    Event date: 2016.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  8. 侵襲性B群レンサ球菌感染症に関する現状と課題

    木村幸司

    第89回日本細菌学会総会 

     More details

    Event date: 2016.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  9. ペニシリン低感受性B群連鎖球菌(Group B Streptococci with reduced penicillin susceptibility, PRGBS)研究

    木村幸司

    第52回日本細菌学会中部支部総会 

     More details

    Event date: 2015.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  10. ペニシリン低感受性B群連鎖球菌(PRGBS)に関する最新知見 International conference

    木村幸司、長野則之、長野由紀子、外山雅美、荒川宜親

    第87回日本感染症学会学術講演会、第61回日本化学療法学会総会 合同学会 

     More details

    Event date: 2013.6

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  11. 連鎖球菌感染症にみられる新しい知見

    木村幸司、長野則之、長野由紀子、外山雅美、荒川宜親

    第61回日本感染症学会東日本地方会学術集会、第59回日本化学療法学会東日本支部総会、合同学会 

     More details

    Event date: 2012.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  12. ペニシリン低感受性B群連鎖球菌の最新の知見

    木村幸司、長野則之、長野由起子、荒川宜親

    第58回日本化学療法学会 

     More details

    Event date: 2010.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:長崎   Country:Japan  

  13. ペニシリン低感受性B群連鎖球菌(PRGBS)の遺伝学的背景に関する解析 International conference

    木村幸司、長野則之、長野由紀子、荒川宜親

    第83回日本細菌学会 

     More details

    Event date: 2010.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  14. ペニシリン低感受性B群連鎖球菌に関する依頼解析

    木村幸司、和知野純一、鈴木里和、山根一和、柴田尚宏、荒川宜親

    第82回日本細菌学会 

     More details

    Event date: 2009.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  15. ペニシリン耐性B群連鎖球菌の出現と耐性機構解析

    木村幸司、鈴木里和、山根一和、柴田尚宏、荒川宜親

    第81回日本感染症学会総会 

     More details

    Event date: 2007.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

▼display all

Research Project for Joint Research, Competitive Funding, etc. 6

  1. 薬剤耐性菌のサーベイランス強化および薬剤耐性菌の総合的な対策に資する研究

    2021

    日本医療研究開発機構(AMED)  新興・再興感染症に対する革新的医薬品等開発推進研究事業 

      More details

    Authorship:Coinvestigator(s)  Grant type:Competitive

  2. 抗菌物質の特性評価

    2021.4 - 2022.3

    共同研究 

      More details

    Authorship:Coinvestigator(s)  Grant type:Collaborative (industry/university)

    Direct Cost: \1500000 )

  3. 多剤耐性菌出現過程でのHypermutable strainの役割の解明

    2016.11

    2016年度 武田科学振興財団 医学系研究奨励(感染症) 

      More details

    Grant type:Competitive

  4. カルバペネマーゼ阻害活性を有する既承認薬をベースとした新たなカルバペネマーゼ阻害薬の開発

    2016 - 2019

    新興・再興感染症に対する革新的医薬品等開発推進研究事業 

      More details

    Authorship:Coinvestigator(s) 

    Direct Cost: \9900000 )

  5. ペニシリン低感受性B群連鎖球菌(PRGBS)選択培地の開発

    2015 - 2016.3

    公益信託 第24回日本医学会総会記念医学振興基金 研究助成 

      More details

    Authorship:Principal investigator  Grant type:Competitive

  6. 多剤耐性菌出現機構の解明に向けた研究

    2012.11

    2012年度 武田科学振興財団 医学系研究奨励(感染症) 

      More details

    Grant type:Competitive

▼display all

KAKENHI (Grants-in-Aid for Scientific Research) 7

  1. カルバペネム耐性肺炎球菌出現機構の解明

    Grant number:23K07920  2023.4 - 2026.3

    科学研究費助成事業  基盤研究(C)

    木村 幸司

      More details

    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    ペニシリン耐性肺炎球菌(PRSP)は、類縁の他菌種からベータラクタム系薬の標的分子、ペニシリン結合タンパク質(PBP)遺伝子の一部を受け取り、ベータラクタム系薬耐性を獲得してきた。近年、PBPsにさらにアミノ酸置換を集積させ、最後の切り札と言われるカルバペネム系薬に耐性を獲得した肺炎球菌が、我が国で分離されたが、本耐性菌のカルバペネム耐性を付与した他菌種のリザーバーは不明である。本研究課題では、「肺炎球菌は、どのようにしてカルバペネム耐性化したのか?どの菌種からカルバペネム耐性遺伝子を受け取ったのか?」という学術的問いに対し、NGS解析等を通して、遺伝子共有、水平伝播、カルバペネム耐性化の様子を明らかにする。

  2. Elucidation of reduced carbapenem susceptibility mechanisms of viridans streptococcus

    Grant number:18K08429  2018.4 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Kimura Kouji

      More details

    Authorship:Principal investigator 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    It was revealed that carbapenem non-susceptible S. mitis / oralis has acquired multiple base substitutions with amino acid substitutions in the target molecule of carbapenem drugs, PBP genes . Interestingly, among those amino acid substitutions, some strains have amino acid substitutions in the conservative region of the transpeptidase domain of PBPs that forms the active site, where β-lactam antibiotics are expected to bind.
    In addition, the introduction of the mutant PBP gene into the S. mitis / oralis standard strain increased the minimum inhibitory concentration of β-lactams, and thus It became clear that the mutation of the PBP gene confer toreduced β-lactams susceptibility.

  3. カルバペネム系抗菌薬全般に低感受性であるインフルエンザ菌の低感受性機構の解析

    2014.4 - 2017.3

    科学研究費補助金  基盤研究(C)

      More details

    Authorship:Principal investigator 

  4. ベータラクタマーゼ阻害薬耐性グラム陰性桿菌の耐性機構の解明と分子疫学解析

    2012.4 - 2014.3

    科学研究費補助金  若手研究(B)

    木村幸司

      More details

    Authorship:Principal investigator 

  5. ペニシリン低感受性B群連鎖球菌のセファロスポリン耐性化に関する研究

    2010.4 - 2012.3

    科学研究費補助金  若手研究(B)

      More details

    Authorship:Principal investigator 

  6. Characterization of IMP-1, a major carbapenem resistance factor in bacteria

    Grant number:15H04868  2015.4 - 2018.3

    Arakawa Yoshichika

      More details

    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

    Emerging of drug-resistant bacteria is a major clinical concern. Thus, it is essential to develop new antibiotics and agents to overcome the problem of drug-resistant bacteria. To respond to the aforementioned urgent and unmet needs, we have screened for metallo-beta-lactamase (MBL) inhibitor. MBL inhibitor can revive the efficacy of carbapenem antibiotics. We have screened 2107 small molecule compounds to identify IMP-1 inhibitor, IMP-1 is the dominant MBL in clinically isolated Enterobacteriaceae. Enzymatic and biological analyses revealed that 8 compounds would be candidates of IMP-1 inhibitor. These 8 compounds would be a great help to overcome carbapenem resistance caused by production of IMP-type MBL.

  7. 神経回路網形成における代謝型グルタミン酸受容体の役割

    1999.4 - 2002.3

    科学研究費補助金 

      More details

    Authorship:Principal investigator 

▼display all

Industrial property rights 2

  1. B群連鎖球菌を検出するためのプライマーセット及びその利用

    荒川宜親、木村幸司、柳沢英二

     More details

    Patent/Registration no:5153726  Date registered:2012.12 

    Country of applicant:Domestic  

  2. ペニシリン耐性B群連鎖球菌(GroupBstreptococcus)を識別する方法及び識別用キット

    木村幸司、黒川博史、荒川宜親

     More details

    Application no:2006−190059  Date applied:2006.7

    Patent/Registration no:特許第4956721号  Date registered:2012.3 

    Country of applicant:Domestic  

 

Teaching Experience (On-campus) 17

  1. 生体と微生物

    2023

  2. 基礎医学セミナー

    2023

  3. 修士必須科目講義

    2023

  4. 大学院ベーシックトレーニング

    2023

  5. 生体と微生物

    2022

  6. 基礎医学セミナー

    2022

  7. 修士必須科目講義

    2022

  8. 大学院ベーシックトレーニング

    2022

  9. 基礎医学セミナー

    2021

  10. ベーシックトレーニング

    2021

  11. 生体と微生物

    2021

  12. 自然環境と人間

    2021

  13. 修士必須科目講義

    2021

  14. ベーシックトレーニング

    2020

  15. 基礎医学セミナー

    2020

  16. 修士必須科目講義

    2020

  17. 生体と微生物

    2020

▼display all

Teaching Experience (Off-campus) 1

  1. 微生物学・基礎感染症学 細菌学・真菌学分野

    2021 Aichi Medical University)

     More details

    Level:Undergraduate (specialized)