Updated on 2022/03/25

写真a

 
KIMURA Kouji
 
Organization
Graduate School of Medicine Program in Integrated Medicine Microbiology and Immunology Associate professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Associate professor
Contact information
メールアドレス

Degree 1

  1. 医学博士 ( 2004.7   京都大学 ) 

Research Interests 1

  1. 薬剤耐性菌 PRGBS ペニシリン低感受性B群連鎖球菌

Research Areas 1

  1. Others / Others  / 感染症学

Research History 9

  1. 名古屋大学大学院医学系研究科 准教授

    2016.4

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    Country:Japan

  2. 名古屋大学大学院医学系研究科 講師

    2012.4 - 2016.3

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    Country:Japan

  3. 名古屋大学大学院医学系研究科 助教

    2011.7 - 2012.3

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    Country:Japan

  4. 国立感染症研究所細菌第二部 主任研究官

    2009.2 - 2011.6

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    Country:Japan

  5. 国立感染症研究所流動研究員

    2006.10 - 2009.1

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    Country:Japan

  6. 国立感染症研究所臨時職員

    2005.4 - 2006.9

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    Country:Japan

  7. 国立感染症研究所流動研究員

    2004.4 - 2005.3

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    Country:Japan

  8. 京都大学大学院医学研究科研修員

    2002.4 - 2004.3

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    Country:Japan

  9. 日本学術振興会特別研究員(DC1)

    1999.4 - 2002.3

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    Country:Japan

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Education 3

  1. Kyoto University   Graduate School, Division of Medical Sciences

    - 2002.3

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    1992.4 - 1998.3

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    Country: Japan

  3. 高田高校(三重県)   6年制

    - 1992.3

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    Country: Japan

Professional Memberships 7

  1. 日本細菌学会   Infection Control Doctor

    2015.1

  2. 日本感染症学会

  3. 日本化学療法学会

  4. 日本臨床微生物学会   評議員

    2013.2

  5. American Society for Microbiology

  6. 日本小児感染症学会

  7. 日本周産期新生児医学会

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Awards 3

  1. 黒屋奨学賞

    2014.3   日本細菌学会  

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    Country:Japan

  2. 第13回日本抗生物質学術協議会奨励賞

    2011   日本抗生物質学術協議会  

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    Country:Japan

  3. 第20回上田泰記念感染症・化学療法研究奨励賞

    2008   日本化学療法学会  

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    Country:Japan

 

Papers 78

  1. Dissecting the clonality of I1 plasmids using ORF-based binarized structure network analysis of plasmids (OSNAp).

    Suzuki M, Norizuki C, Wachino JI, Kawamura K, Nagano N, Nagano Y, Hayashi W, Kimura K, Doi Y, Arakawa Y

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   Vol. 28 ( 4 ) page: 473 - 479   2022.4

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    Language:English  

    DOI: 10.1016/j.jiac.2021.12.003

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  2. Molecular Epidemiology of Enterobacter cloacae Complex Isolates with Reduced Carbapenem Susceptibility Recovered by Blood Culture

    Sarangi Jayathilake, Matsuo Nao, Nonogaki Rina, Hayashi Michiko, Kawamura Kumiko, Suzuki Masahiro, Jin Wanchun, Tamai Kiyoko, Ogawa Miho, Wachino Jun-ichi, Kimura Kouji, Yagi Tetsuya, Arakawa Yoshichika

    JAPANESE JOURNAL OF INFECTIOUS DISEASES   Vol. 75 ( 1 ) page: 41 - 48   2022.1

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  3. Isolation of Group A Streptococci with Reduced In Vitro beta-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan

    Ikeda Tsubasa, Suzuki Rihito, Jin Wanchun, Wachino Jun-Ichi, Arakawa Yoshichika, Kimura Kouji

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   Vol. 65 ( 12 ) page: e0148221   2021.11

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  4. Practical Agar-Based Disk Diffusion Tests Using Sulfamoyl Heteroarylcarboxylic Acids for Identification of Subclass B1 Metallo-beta-Lactamase-Producing Enterobacterales

    Norizuki Chihiro, Wachino Jun-ichi, Jin Wanchun, Kimura Kouji, Kawamura Kumiko, Nagano Noriyuki, Arakawa Yoshichika

    JOURNAL OF CLINICAL MICROBIOLOGY   Vol. 59 ( 10 ) page: e0076121   2021.10

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  5. Daptomycin Susceptibility of Group B Streptococcus

    Ushino Takumi, Jin Wanchun, Wachino Jun-Ichi, Arakawa Yoshichika, Kimura Kouji

    JAPANESE JOURNAL OF INFECTIOUS DISEASES   Vol. 74 ( 3 ) page: 233 - 235   2021.5

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  6. Daptomycin susceptibility of group B Streptococcus Reviewed

    T. Ushino, W. Jin, J. Wachino, Y. Arakawa, K. Kimura*

    the Japanese Journal of Infectious Diseases   Vol. in press   2021

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  7. Sulfamoyl Heteroarylcarboxylic Acids as Promising Metallo-beta-Lactamase Inhibitors for Controlling Bacterial Carbapenem Resistance

    Wachino Jun-ichi, Jin Wanchun, Kimura Kouji, Kurosaki Hiromasa, Sato Ayato, Arakawa Yoshichika

    MBIO   Vol. 11 ( 2 )   2020

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  8. Erythromycin-Susceptible but Clindamycin-Resistant Phenotype of Clinical ermB-PCR-Positive Group B Streptococci Isolates with IS1216E-Inserted ermB. Reviewed International coauthorship

    Moroi H, Kimura K, Ido A, Banno H, Jin W, Wachino JI, Yamada K, Kikkawa F, Park YJ, Arakawa Y

    Japanese journal of infectious diseases   Vol. 72 ( 6 ) page: 420 - 422   2019.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.7883/yoken.JJID.2019.015

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  9. 4-Amino-2-Sulfanylbenzoic Acid as a Potent Subclass B3 Metallo-beta-Lactamase-Specific Inhibitor Applicable for Distinguishing Metallo-beta-Lactamase Subclasses

    Wachino Jun-ichi, Kanechi Reo, Nishino Erina, Mochizuki Marie, Jin Wanchun, Kimura Kouji, Kurosaki Hiromasa, Arakawa Yoshichika

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   Vol. 63 ( 10 )   2019.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/AAC.01197-19

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  10. Intercellular Transfer of Chromosomal Antimicrobial Resistance Genes between Acinetobacter baumannii Strains Mediated by Prophages

    Wachino Jun-ichi, Jin Wanchun, Kimura Kouji, Arakawa Yoshichika

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   Vol. 63 ( 8 )   2019.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/AAC.00334-19

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  11. Spread of seb-Positive Methicillin-Resistant Staphylococcus aureus SCCmec Type II-ST764 Among Elderly Japanese in Nonacute Care Settings

    Kawamura Kumiko, Kitaoka Kazuki, Kimura Kouji, Wachino Jun-ichi, Kondo Takaaki, Iinuma Yoshitsugu, Murakami Nobuo, Fujimoto Shuhei, Arakawa Yoshichika

    MICROBIAL DRUG RESISTANCE   Vol. 25 ( 6 ) page: 915 - 924   2019.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/mdr.2018.0337

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  12. First Case in Korea of Group B Streptococcus With Reduced Penicillin Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Protein 2X

    Yi Ahram, Kim Chang-Ki, Kimura Kouji, Arakawa Yoshichika, Hur Mina, Yun Yeo-Min, Moon Hee-Won

    ANNALS OF LABORATORY MEDICINE   Vol. 39 ( 4 ) page: 414 - 416   2019.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3343/alm.2019.39.4.414

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  13. Relatively high rates of cefotaxime- and ceftriaxone-non-susceptible isolates among group B streptococci with reduced penicillin susceptibility (PRGBS) in Japan

    Kitamura Masaki, Kimura Kouji, Ido Ayaka, Seki Tomomi, Banno Hirotsugu, Jin Wanchun, Wachino Jun-ichi, Yamada Keiko, Arakawa Yoshichika

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY   Vol. 74 ( 4 ) page: 931 - 934   2019.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jac/dky542

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  14. Population-level transition of capsular polysaccharide types among sequence type 1 group B Streptococcus isolates with reduced penicillin susceptibility during a long-term hospital epidemic

    Nagano Noriyuki, Koide Shota, Hayashi Wataru, Taniguchi Yui, Tanaka Hayato, Maeyama Yoshihiko, Suzuki Masahiro, Kimura Kouji, Arakawa Yoshichika, Nagano Yukiko

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS   Vol. 53 ( 3 ) page: 203 - 210   2019.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijantimicag.2018.11.003

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  15. Potential effect of selective pressure with different beta-lactam molecules on the emergence of reduced susceptibility to beta-lactams in group B Streptococci

    Koide Shota, Hayashi Wataru, Taniguchi Yui, Tanaka Hayato, Kimura Kouji, Nagano Yukiko, Arakawa Yoshichika, Nagano Noriyuki

    MICROBIOLOGY AND IMMUNOLOGY   Vol. 63 ( 2 ) page: 65 - 76   2019.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1348-0421.12667

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  16. Isolation of group B Streptococcus with reduced beta-lactam susceptibility from pregnant women

    Moroi Hiroaki, Kimura Kouji, Kotani Tomomi, Tsuda Hiroyuki, Banno Hirotsugu, Jin Wanchun, Wachino Jun-ichi, Yamada Keiko, Mitsui Takashi, Yamashita Mamoru, Kikkawa Fumitaka, Arakawa Yoshichika

    EMERGING MICROBES & INFECTIONS   Vol. 8 ( 1 ) page: 2 - 7   2019.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/22221751.2018.1557987

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  17. Prevalence of CTX-M-Type Extended-Spectrum -Lactamase-Producing Escherichia coli B2-O25-ST131 H30R Among Residents in Nonacute Care Facilities in Japan

    Kawamura Kumiko, Hayashi Kengo, Matsuo Nao, Kitaoka Kazuki, Kimura Kouji, Wachino Jun-ichi, Kondo Takaaki, Iinuma Yoshitsugu, Murakami Nobuo, Fujimoto Shuhei, Arakawa Yoshichika

    MICROBIAL DRUG RESISTANCE   Vol. 24 ( 10 ) page: 1513 - 1520   2018.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/mdr.2018.0068

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  18. High prevalence of bla(CTX-M-14) among genetically diverse Escherichia coli recovered from retail raw chicken meat portions in Japan

    Hayashi Wataru, Ohsaki Yusuke, Taniguchi Yui, Koide Shota, Kawamura Kumiko, Suzuki Masahiro, Kimura Kouji, Wachino Jun-ichi, Nagano Yukiko, Arakawa Yoshichika, Nagano Noriyuki

    INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY   Vol. 284   page: 98 - 104   2018.11

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    DOI: 10.1016/j.ijfoodmicro.2018.08.003

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  19. A nationwide population-based surveillance of invasive Haemophilus influenzae diseases in children after the introduction of the Haemophilus influenzae type b vaccine in Japan.

    Suga S, Ishiwada N, Sasaki Y, Akeda H, Nishi J, Okada K, Fujieda M, Oda M, Asada K, Nakano T, Saitoh A, Hosoya M, Togashi T, Matsuoka M, Kimura K, Shibayama K

    Vaccine   Vol. 36 ( 38 ) page: 5678 - 5684   2018.9

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    DOI: 10.1016/j.vaccine.2018.08.029

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  20. Carbapenem-Nonsusceptible Haemophilus influenzae with Penicillin-Binding Protein 3 Containing an Amino Acid Insertion

    Kitaoka Kazuki, Kimura Kouji, Kitanaka Hiromitsu, Banno Hirotsugu, Jin Wanchun, Wachino Jun-ichi, Arakawa Yoshichika

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   Vol. 62 ( 8 )   2018.8

  21. High isolation rate and multidrug resistance tendency of penicillin-susceptible group B Streptococcus with reduced ceftibuten susceptibility in Japan

    Banno Hirotsugu, Kimura Kouji, Seki Tomomi, Jin Wanchun, Wachino Jun-ichi, Yamada Keiko, Nagano Noriyuki, Arakawa Yoshichika

    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES   Vol. 37 ( 8 ) page: 1511 - 1519   2018.8

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  22. Carbapenem-Nonsusceptible Haemophilus influenzae with Penicillin-Binding Protein 3 Containing an Amino Acid Insertion.

    Kitaoka K, Kimura K, Kitanaka H, Banno H, Jin W, Wachino JI, Arakawa Y

    Antimicrobial agents and chemotherapy   Vol. 62 ( 8 )   2018.8

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    DOI: 10.1128/AAC.00671-18

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  23. Predominance of Serogroup 19 CC320/271 among Penicillin-Nonsusceptible Streptococcus pneumoniae Isolates after Introduction of the PCV7 Vaccine in Several Regions of Japan

    Oodate Mitsuru, Kimura Kouji, Banno Hirotsugu, Yokoyama Satoru, Jin Wanchun, Wachino Jun-ichi, Hasegawa Yoshinori, Arakawa Yoshichika

    JAPANESE JOURNAL OF INFECTIOUS DISEASES   Vol. 71 ( 1 ) page: 14 - 20   2018.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.7883/yoken.JJID.2017.236

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  24. Carbapenem-non-Susceptible Haemophilus influenzae with Penicillin-Binding Protein 3 containing Amino Acid Insertion Reviewed

    K. Kitaoka, K. Kimura*, H. Kitanaka, H. Banno, W. Jin, J. Wachino, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 62 ( 8 ) page: e00671-18   2018

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  25. High isolation rate and multidrug resistance tendency of penicillin-susceptible group B Streptococcus with reduced ceftibuten susceptibility in Japan Reviewed

    H. Banno, K. Kimura*, T. Seki, W. Jin, J. Wachino, K. Yamada, N. Nagano, Y. Arakawa

    European Journal of Clinical Microbiology & Infectious Diseases   Vol. 37 ( 8 ) page: 1511-1519   2018

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  26. Population-level transition of capsular polysaccharide types among sequence type 1 group B Streptococcus isolates with reduced penicillin susceptibility during their long-term hospital epidemic Reviewed

    N. Nagano, S. Koide, W. Hayashi, Y. Taniguchi, H. Tanaka, Y. Maeyama, M. Suzuki, K. Kimura, Y. Arakawa, Y. Nagano

    International Journal of Antimicrobial Agents     page: In press   2018

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  27. A nationwide population-based surveillance of invasive Haemophilus influenzae diseases in children after the introduction of the Haemophilus influenzae type b vaccine in Japan Reviewed

    S. Suga, N. Ishiwada, Y. Sasaki, H. Akeda, J. Nishi, K. Okada, M. Fujieda, M. Oda, K. Asada, T. Nakano, A. Saitoh, M. Hosoya, T. Togashi, M. Matsuoka, K. Kimura, K. Shibayama

    Vaccine   Vol. 36   page: 5678-5684   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

  28. High prevalence of blaCTX-M-14 among genetically diverse Escherichia coli recovered from retail raw chicken meat portions in Japan Reviewed

    W. Hayashi, Y. Ohsaki, Y. Taniguchi, S. Koide, K. Kawamura, M. Suzuki, K. Kimura, J. Wachino, Y. Nagano, Y. Arakawa, N. Nagano

    International Journal of Food Microbiology   Vol. 284   page: 98-104   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

  29. Prevalence of CTX-M-type extended-spectrum β-lactamase-producing Escherichia coli B2-O25-ST131 H30R among residents in nonacute care facilities in Japan Reviewed

    K. Kawamura, K. Hayashi, N. Matsuo, K. Kitaoka, K. Kimura, J. Wachino, T Kondo, Y. Iinuma, N. Murakami, S. Fujimoto, Y. Arakawa

    Microbial Drug Resistance     page: doi: 10.1089/mdr.2018.0068   2018

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  30. Structural Insights into the TLA-3 Extended-Spectrum beta-Lactamase and Its Inhibition by Avibactarn and OP0595

    Jin Wanchun, Wachino Jun-ichi, Yamaguchi Yoshihiro, Kimura Kouji, Kumar Anupriya, Yamada Mototsugu, Morinaka Akihiro, Sakamaki Yoshiaki, Yonezawa Minoru, Kurosaki Hiromasa, Arakawa Yoshichika

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   Vol. 61 ( 10 )   2017.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/AAC.00501-17

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  31. Analysis of multidrug resistant group B streptococci with reduced penicillin susceptibility forming small, less hemolytic colonies

    Banno Hirotsugu, Kimura Kouji, Tanaka Yosuke, Sekizuka Tsuyoshi, Kuroda Makoto, Jin Wanchun, Wachino Jun-ichi, Yamada Keiko, Shibayama Keigo, Arakawa Yoshichika

    PLOS ONE   Vol. 12 ( 8 ) page: e0183453   2017.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0183453

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  32. Specific bla(CTX-M-8)/IncI1 Plasmid Transfer among Genetically Diverse Escherichia coli Isolates between Humans and Chickens

    Norizuki Chihiro, Wachino Jun-ichi, Suzuki Masahiro, Kawamura Kumiko, Nagano Noriyuki, Kimura Kouji, Arakawa Yoshichika

    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY   Vol. 61 ( 6 )   2017.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/AAC.00663-17

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  33. High rate of slowly-killed-by-ampicillin phenotype among group B streptococci with reduced penicillin susceptibility

    Taniguchi Rina, Kimura Kouji, Miyazaki Akira, Banno Hirotsugu, Jin Wanchun, Yamada Keiko, Wachino Jun-ichi, Arakawa Yoshichika

    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY   Vol. 72 ( 3 ) page: 941 - 942   2017.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jac/dkw500

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  34. Structural insights into recognition of hydrolyzed carbapenems and inhibitors by subclass B3 metallo-β-lactamase SMB-1 Reviewed

    J. Wachino, Y. Yamaguchi, S. Mori, W. Jin, K. Kimura, H. Kurosaki, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 60 ( 7 ) page: 4274-82   2016

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  35. A highly macrolide-resistant Campylobacter jejuni strain with rare A2074T mutations in 23S rRNA genes Reviewed

    H. Ohno, J. Wachino, R. Saito, W. Jin, K. Yamada, K. Kimura, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 60 ( 4 ) page: 2580-1   2016

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  36. Effectual detection of group B streptococci with reduced penicillin susceptibility (PRGBS) by commercially available methicillin-resistant-Staphylococcus aureus (MRSA)-selective agar Reviewed

    S. Fukigai¶, M. Morimoto¶, K. Kimura*, Y. Doyama, A. Miyazaki, C. Kamiya, H. Banno, E. Morishima, T. Onoda, N. Nagano, W. Jin, J. Wachino, K. Yamada, Y. Arakawa

    Diagnostic Microbiology and Infectious Disease   Vol. 85 ( 3 ) page: 309-12   2016

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  37. In vitro reduction of antibacterial activity of tigecycline against multidrug-resistant Acinetobacter baumannii with host stress hormone norepinephrine Reviewed

    M. Inaba, N. Matsuda, H. Banno, W. Jin, J. Wachino, K. Yamada, K. Kimura, Y. Arakawa

    International Journal of Antimicrobial Agents     page: in press   2016

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  38. Comparative Analysis of Penicillin-Susceptible and Non-Susceptible Isolates in Group B Streptococci by Multilocus Sequence Typing Reviewed

    R. Yamada, K. Kimura*, N. Nagano, Y. Nagano, S. Suzuki, W. Jin, J. Wachino, K. Yamada, K. Shibayama, Y. Arakawa

    Japanese Journal of Infectious Diseases   Vol. 68 ( 4 ) page: 326-329   2015

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  39. Genetic Profiles of Fluoroquinolone-Nonsusceptible Klebsiella pneumoniae Among Cephalosporin-Resistant K. pneumoniae Reviewed

    Y. Nagasaka, K. Kimura, K. Yamada, J. Wachino, W. Jin, S. Notake, H. Yanagisawa, Y. Arakawa

    Microbial Drug Resistance   Vol. 21 ( 2 ) page: 224-33   2015

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  40. Have Group A Streptococci with Reduced Penicillin Susceptibility Emerged? Reviewed

    T. Suzuki, K. Kimura*, H. Suzuki, H. Banno, W. Jin, J. Wachino, K. Yamada, Y. Arakawa

    The Journal of Antimicrobial Chemotherapy   Vol. 70 ( 4 ) page: 1258-9   2015

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  41. New Plasmid-Mediated Aminoglycoside 6'-N-Acetyltransferase, AAC(6')-Ian, and Extended-Spectrum β-Lactamase, TLA-3, from Serratia marcescens Clinical Isolate Reviewed

    W. Jin, J. Wachino, K. Kimura, K. Yamada, Y. Arakawa

    The Journal of Antimicrobial Chemotherapy   Vol. 70 ( 5 ) page: 1331-7   2015

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  42. Molecular Epidemiological Characteristics of Klebsiella pneumoniae Associated with Bacteremia among Patients with Pneumonia Reviewed

    R. Ito, Y. Shindo, D. Kobayashi, M. Ando, W. Jin, J. Wachino, K. Yamada, K. Kimura, T. Yagi, Y. Hasegawa, Y. Arakawa

    Journal Clinical Microbiology   Vol. 53 ( 3 ) page: 879-86   2015

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  43. Classification of Group B Streptococci with Reduced β-Lactam Susceptibility (GBS-RBS) Based on the Amino Acid Substitutions in Penicillin-binding Proteins (PBPs) Reviewed

    K. Kimura*, N. Nagano, Y. Arakawa

    The Journal of Antimicrobial Chemotherapy   Vol. 70 ( 6 ) page: 1601-1603   2015

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  44. Ceftibuten-Containing Agar Plate for Detecting Group B Streptococci with Reduced Penicillin Susceptibility (PRGBS) Reviewed

    C. Kamiya, K. Kimura*, Y. Doyama, A. Miyazaki, M. Morimoto, H. Banno, N. Nagano, W. Jin, J. Wachino, K. Yamada, Y. Arakawa

    Diagnostic Microbiology and Infectious Disease   Vol. 82 ( 4 ) page: 269-273   2015

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  45. High isolation rate of multi-drug resistant group B streptococci with reduced penicillin susceptibility in Japan Reviewed

    T. Seki, K. Kimura*, M. E. Reid, A. Miyazaki, H. Banno, W. Jin, J. Wachino, K. Yamada, Y. Arakawa

    The Journal of Antimicrobial Chemotherapy   Vol. 70 ( 10 ) page: 2725-2728   2015

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  46. Characterization of piperacillin/tazobactam-resistant Klebsiella oxytoca recovered from a nosocomial outbreak Reviewed

    A. Fujita, K. Kimura*, S. Yokoyama, W. Jin, J. Wachino, K. Yamada, H. Suematsu, Y. Yamagishi, H. Mikamo, Y. Arakawa

    PLOS ONE   Vol. 10 ( 11 ) page: e0142366   2015

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  47. Characterization of Multi-drug-Resistant Group B Streptococci with Reduced Penicillin Susceptibility (PRGBS) Forming Small Non-β-hemolytic Colonies on Sheep Blood Agar Plates Reviewed

    H. Banno, K. Kimura*, Y. Tanaka, H. Kitanaka, W. Jin, J. Wachino, K. Yamada, K. Shibayama, Y. Arakawa

    Journal Clinical Microbiology   Vol. 52 ( 6 ) page: 2169-71   2014

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  48. Novel integron-mediated fosfomycin-resistance genetic determinant, fosK Reviewed

    H. Kitanaka, J. Wachino, W. Jin, S. Yokoyama, M. Sasano, M. Hori, K. Yamada, K. Kimura, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 58 ( 8 ) page: 4978-9   2014

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    Language:English   Publishing type:Research paper (scientific journal)  

  49. Penicillin-susceptible group B streptococcal clinical isolates with reduced cephalosporin susceptibility Reviewed

    N. Nagano, Y. Nagano, M. Toyama, K. Kimura, K. Shibayama, Y. Arakawa

    Journal Clinical Microbiology   Vol. 52 ( 9 ) page: 3406-10   2014

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  50. Carbapenem-resistant Acinetobacter soli as a newly emerging invasive pathogen Reviewed

    H. Kitanaka, M. Sasano, S. Yokoyama, M. Suzuki, W. Jin, M. Inayoshi, M. Hori, J. Wachino, K. Kimura, K. Yamada, Y. Arakawa

    Emerging Infectious Disease   Vol. 20 ( 9 ) page: 1574-6   2014

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  51. Practical Agar-Based Disk Potentiation Test to Detect Fosfomycin-Non-Susceptible Escherichia coli Clinical Isolates Producing Glutathione S-Transferases. Reviewed

    G. Nakamura, J. Wachino, N. Sato, K. Kimura, K. Yamada, W. Jin, K. Shibayama, T. Yagi, K. Kawamura, Y. Arakawa

    Journal Clinical Microbiology   Vol. 52 ( 9 ) page: 3175-9   2014

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  52. Evaluation of Disk Potentiation Test Using KB Disks Containing High Dosage Fosfomycin and Glucose-6-Phosphate to Detect the Production of Glutathione S-Transferase Responsible For Fosfomycin Resistance Reviewed

    J. Wachino, K. Kimura, K. Yamada, W. Jin, Y. Arakawa

    Journal Clinical Microbiology   Vol. 52 ( 10 ) page: 3827-8   2014

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    Language:English   Publishing type:Research paper (scientific journal)  

  53. The incidence of pediatric invasive Haemophilus influenzae and pneumococcal disease in Chiba prefecture, Japan before and after the introduction of conjugate vaccines Reviewed

    N Ishiwada, H Hishiki, K Nagasawa, S Naito, Y Sato, B Chang, Y Sasaki, K Kimura, M Ohnishi, K Shibayama

    Vaccine   Vol. 32 ( 42 ) page: 5425-31   2014

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    Language:English   Publishing type:Research paper (scientific journal)  

  54. Screening for Group B Streptococci with Reduced Penicillin Susceptibility (PRGBS) in Clinical Isolates Obtained between 1977 and 2005 Reviewed

    K. Kimura, Y. Nishiyama, S. Shimizu, J. Wachino, M. Matsui, S. Suzuki, K. Yamane, K. Shibayama, Y. Arakawa

    Japanese Journal of Infectious Diseases   Vol. 66 ( 3 ) page: 222-225   2013

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  55. Rapid and reliable loop-mediated isothermal amplification method for detecting Streptococcus agalactiae Reviewed

    K. Kimura, H. Yanagisawa, J. Wachino, K. Shibayama, Y. Arakawa

    Japanese Journal of Infectious Diseases   Vol. 66   page: 546-548   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

  56. High Frequency of Fluoroquinolone- and Macrolide-resistant Streptococci among Clinically Isolated Group B Streptococci with Reduced Penicillin Susceptibility Reviewed

    K. Kimura, N. Nagano, Y. Nagano, S. Suzuki, J. Wachino, K. Shibayama, Y. Arakawa

    The Journal of Antimicrobial Chemotherapy   Vol. 68 ( 3 ) page: 539-42   2013

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  57. Active Screening of Group B Streptococci with Reduced Penicillin Susceptibility and Altered Serotype Distribution, Isolated from Pregnant Women in Kobe, Japan Reviewed

    K. Kimura, K. Matsubara, G. Yamamoto, K. Shibayama, Y. Arakawa

    Japanese Journal of Infectious Diseases   Vol. 66 ( 2 ) page: 158-60   2013

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  58. Ability of the VITEK® 2 System to Detect Group B Streptococci with Reduced Penicillin Susceptibility (PRGBS) Reviewed

    K. Kimura, N. Nagano, Y. Nagano, J. Wachino, K. Shibayama, Y. Arakawa

    The Journal of Antimicrobial Chemotherapy   Vol. 68 ( 6 ) page: 1442-4   2013

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  59. High cephalosporin resistance due to amino acid substitutions in PBP1A and PBP2X in a clinical isolate of group B streptococcus Reviewed

    K. Kimura, J. Wachino, H. Kurokawa, M. Matsui, S. Suzuki, K. Yamane, N. Nagano, K. Shibayama, Y. Arakawa

    The Journal of Antimicrobial Chemotherapy   Vol. 68 ( 7 ) page: 1533-1536   2013

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  60. Nosocomial spread of multidrug-resistant group B streptococci with reduced penicillin susceptibility belonging to clonal complex 1 Reviewed

    N. Nagano, Y. Nagano, M. Toyama, K. Kimura, T. Tamura, K. Shibayama, Y. Arakawa

    The Journal of Antimicrobial Chemotherapy   Vol. 67 ( 4 ) page: 849-856   2012

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    Language:English   Publishing type:Research paper (scientific journal)  

  61. Predominance of sequence type 1 group with serotype VI among group B atreptococci with reduced penicillin susceptibility identified in Japan Reviewed

    K. Kimura, N. Nagano, Y. Nagano, J. Wachino, S. Suzuki, K. Shibayama, Y. Arakawa

    The Journal of Antimicrobial Chemotherapy   Vol. 66   page: 2460-2464   2011

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    Language:English   Publishing type:Research paper (scientific journal)  

  62. Prevalence of Fosfomycin Resistance among CTX-M-Producing Escherichia coli Clinical Isolates in Japan and Identification of Novel Plasmid-Mediated Fosfomycin-Modifying Enzymes Reviewed

    J. Wachino, K. Yamane, S. Suzuki, K. Kimura, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 54 ( 7 ) page: 3061-3064   2010

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    Language:English   Publishing type:Research paper (scientific journal)  

  63. RmtC introduces G1405 methylation in 16S rRNA and confers high-level aminoglycoside resistance on Gram-positive microorganisms Reviewed

    J. Wachino, K. Shibayama, K. Kimura, K. Yamane, S. Suzuki, Y. Arakawa

    FEMS Microbiol Lett   Vol. 311 ( 1 ) page: 56-60   2010

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  64. Molecular characterization of group B streptococci with reduced penicillin susceptibility recurrently isolated from a sacral decubitus ulcer Reviewed

    N. Nagano, K. Kimura, Y. Nagano, H. Yakumaru, Y. Arakawa

    The Journal of Antimicrobial Chemotherapy   Vol. 64 ( 6 ) page: 1326-1328   2009

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  65. Practical disk diffusion test for detecting group B streptococcus with reduced penicillin susceptibility Reviewed

    K. Kimura, J. Wachino, H. Kurokawa, S. Suzuki, K. Yamane, N. Shibata, Y. Arakawa

    Journal Clinical Microbiology   Vol. 47 ( 12 ) page: 4154-4157   2009

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    Language:English   Publishing type:Research paper (scientific journal)  

  66. First Molecular Characterization of Group B Streptococci with Reduced Penicillin Susceptibility Reviewed

    K. Kimura, S. Suzuki, J. Wachino, H. Kurokawa, K. Yamane, N. Shibata, N. Nagano, H. Kato, K. Shibayama,, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 52   page: 2890-2897   2008

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    Language:English   Publishing type:Research paper (scientific journal)  

  67. Genetic heterogeneity in pbp genes among clinically isolated group B streptococci with reduced penicillin susceptibility Reviewed

    N. Nagano, Y. Nagano, K. Kimura, K. Tamai, H. Yanagisawa, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 52   page: 4258-4267   2008

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    Language:English   Publishing type:Research paper (scientific journal)  

  68. New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate Reviewed

    K. Yamane, J. Wachino, S. Suzuki, K. Kimura, N. Shibata, H. Kato, K. Shibayama, T. Konda, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 51 ( 9 ) page: 3354-336   2007

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    Language:English   Publishing type:Research paper (scientific journal)  

  69. Novel Plasmid-Mediated 16S rRNA m1A1408 Methyltransferase, NpmA, Found in a Clinically Isolated Escherichia coli Strain Resistant to Structurally Diverse Aminoglycosides Reviewed

    J. Wachino, K. Shibayama, H. Kurokawa, K. Kimura, K. Yamane, S. Suzuki, N. Shibata, Y. Ike, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 51 ( 12 ) page: 4401-4409   2007

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    Language:English   Publishing type:Research paper (scientific journal)  

  70. 16S rRNA methylase-producing, gram-negative pathogens, Japan Reviewed

    K. Yamane, J. Wachino, S. Suzuki, N. Shibata, H. Kato, K. Shibayama, K. Kimura, K. Kai, S. Ishikawa, Y. Ozawa, T. Konda, Y. Arakawa

    Emerging Infectious Disease   Vol. 13 ( 4 ) page: 642-646   2007

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    Language:English   Publishing type:Research paper (scientific journal)  

  71. PCR Classification of CTX-M Type beta-Lactamase Genes Identified In Clinically Isolated Gram-Negative Bacilli in Japan Reviewed

    N. Shibata, H. Kurokawa, Y. Doi, T. Yagi, K. Yamane, J. Wachino, S. Suzuki, K. Kimura, S. Ishikawa, H. Kato, Y. Ozawa, K. Shibayama, K. Kai, T. Konda, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 50   page: 791-795   2006

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    Language:English   Publishing type:Research paper (scientific journal)  

  72. Mode of transposition and expression of 16S rRNA methyltransferase gene rmtC accompanied by ISEcp1 Reviewed

    J. Wachino, K. Yamane, K. Kimura N. Shibata, S. Suzuki Y. Ike Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 50   page: 3212-3215   2006

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    Language:English   Publishing type:Research paper (scientific journal)  

  73. Novel Plasmid-Mediated 16S rRNA Methylase, RmtC, Found in Proteus mirabilis Demonstrating Extraordinary High-Level Resistance against Various Aminoglycoside Reviewed

    J. Wachino, K. Yamane, K. Shibayama, H. Kurokawa, N. Shibata, S. Suzuki, Y. Doi, K. Kimura, Y. Ike, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 50   page: 178-184   2006

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    Language:English   Publishing type:Research paper (scientific journal)  

  74. Horizontal Transfer of blaCMY-Bearing Plasmids among Clinical Escherichia coli and Klebsiella pneumoniae Isolates, and Emergence of Cefepime-Hydrolyzing CMY-19 Reviewed

    J. Wachino, H. Kurokawa, S. Suzuki, K. Yamane, N. Shibata, K. Kimura, Y. Ike, Y. Arakawa

    Antimicrobial Agents and Chemotherapy   Vol. 50   page: 534-541   2006

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    Language:English   Publishing type:Research paper (scientific journal)  

  75. Hyperpolarization-activated, cyclic nucleotide-gated HCN2 cation channel forms a protein assembly with multiple neuronal scaffold proteins in distinct modes of protein-protein interaction Reviewed

    K. Kimura, J. Kitano, Y. Nakajima, S. Nakanishi

    Genes to Cells   Vol. 9   page: 631-640   2004

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  76. Tamalin Is a Scaffold Protein That Interacts with Multiple Neuronal Proteins in Distinct Modes of Protein-Protein Association Reviewed

    J. Kitano, Y. Yamazaki, K. Kimura, T. Masukado, Y. Nakajima, S. Nakanishi

    The Journal of Biological Chemistry   Vol. 278   page: 14762-14768   2003

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  77. Tamalin, a PDZ Domain-Containing Protein, Links a Protein Complex Formation of Group 1 Metabotropic Glutamate Receptors and the Guanine Nucleotide Exchange Factor Cytohesins Reviewed

    J. Kitano, K. Kimura, Y. Yamazaki, T. Soda, R. Shigemoto, Y. Nakajima, S. Nakanishi

    The Journal of Neuroscience   Vol. 22   page: 1280-1289   2002

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  78. Molecular Aspects of High-Level Resistance to Sulbactam-Cefoperazone in Klebsiella oxytoca Clinical Isolates Reviewed

    K. Kimura, Y. Arakawa, S. Ohsuka, H. Ito, K. Suzuki, H. Kurokawa, N. Kato, M. Ohta

    Antimicrobial Agents and Chemotherapy   Vol. 40   page: 1988-1994   1996

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Presentations 14

  1. B群レンサ球菌

    木村幸司

    第90回日本感染症学会西日本地方会学術集会・第63回日本感染症学会中日本地方会学術集会・第68回日本化学療法学会西日本支部総会  2020.11.7 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡  

  2. レンサ球菌 Invited

    木村幸司

    第68回日本化学療法学会総会  2020.9.13 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:神戸  

  3. 細菌検査から始まる薬剤耐性研究

    木村幸司、黒川博史、長野則之、荒川宜親

    第94回日本感染症学会総会 

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    Event date: 2020.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:東京   Country:Japan  

  4. β—ラクタム系薬低感受性B群レンサ球菌(GBS-RBS) Invited

    木村幸司、長野則之、荒川宜親

    第93回日本細菌学会総会 

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    Event date: 2020.2

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:名古屋   Country:Japan  

  5. Group B Streptococcus with reduced beta-lactam susceptibility (GBS-RBS) Invited

    K. Kimura, N. Nagano, Y. Arakawa

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    Event date: 2020.1 - 2020.2

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  6. PRGBSを含むβラクタム系薬低感受性B群レンサ球菌(GBS-RBS)に関する研究

    木村幸司、長野則之、荒川宜親

    第89回日本細菌学会総会 

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    Event date: 2016.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  7. 侵襲性B群レンサ球菌感染症に関する現状と課題

    木村幸司

    第89回日本細菌学会総会 

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    Event date: 2016.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  8. ペニシリン低感受性B群連鎖球菌(Group B Streptococci with reduced penicillin susceptibility, PRGBS)研究

    木村幸司

    第52回日本細菌学会中部支部総会 

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    Event date: 2015.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  9. ペニシリン低感受性B群連鎖球菌(PRGBS)に関する最新知見 International conference

    木村幸司、長野則之、長野由紀子、外山雅美、荒川宜親

    第87回日本感染症学会学術講演会、第61回日本化学療法学会総会 合同学会 

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    Event date: 2013.6

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  10. 連鎖球菌感染症にみられる新しい知見

    木村幸司、長野則之、長野由紀子、外山雅美、荒川宜親

    第61回日本感染症学会東日本地方会学術集会、第59回日本化学療法学会東日本支部総会、合同学会 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  11. ペニシリン低感受性B群連鎖球菌の最新の知見

    木村幸司、長野則之、長野由起子、荒川宜親

    第58回日本化学療法学会 

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    Event date: 2010.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:長崎   Country:Japan  

  12. ペニシリン低感受性B群連鎖球菌(PRGBS)の遺伝学的背景に関する解析 International conference

    木村幸司、長野則之、長野由紀子、荒川宜親

    第83回日本細菌学会 

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    Event date: 2010.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  13. ペニシリン低感受性B群連鎖球菌に関する依頼解析

    木村幸司、和知野純一、鈴木里和、山根一和、柴田尚宏、荒川宜親

    第82回日本細菌学会 

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    Event date: 2009.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  14. ペニシリン耐性B群連鎖球菌の出現と耐性機構解析

    木村幸司、鈴木里和、山根一和、柴田尚宏、荒川宜親

    第81回日本感染症学会総会 

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    Event date: 2007.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

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Research Project for Joint Research, Competitive Funding, etc. 3

  1. 多剤耐性菌出現過程でのHypermutable strainの役割の解明

    2016.11

    2016年度 武田科学振興財団 医学系研究奨励(感染症) 

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    Grant type:Competitive

  2. ペニシリン低感受性B群連鎖球菌(PRGBS)選択培地の開発

    2015

    公益信託 第24回日本医学会総会記念医学振興基金 研究助成 

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    Grant type:Competitive

  3. 多剤耐性菌出現機構の解明に向けた研究

    2012.11

    2012年度 武田科学振興財団 医学系研究奨励(感染症) 

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    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 7

  1. カルバペネム系低感受性緑色レンサ球菌のカルバペネム低感受性機構の解明

    2018.4 - 2021.3

    科学研究費補助金  基盤研究(C)

    木村幸司

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    Authorship:Principal investigator 

  2. カルバペネム系抗菌薬全般に低感受性であるインフルエンザ菌の低感受性機構の解析

    2014.4 - 2017.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  3. ベータラクタマーゼ阻害薬耐性グラム陰性桿菌の耐性機構の解明と分子疫学解析

    2012.4 - 2014.3

    科学研究費補助金  若手研究(B)

    木村幸司

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    Authorship:Principal investigator 

  4. ペニシリン低感受性B群連鎖球菌のセファロスポリン耐性化に関する研究

    2010.4 - 2012.3

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

  5. 神経回路網形成における代謝型グルタミン酸受容体の役割

    1999.4 - 2002.3

    科学研究費補助金 

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    Authorship:Principal investigator 

  6. Elucidation of reduced carbapenem susceptibility mechanisms of viridans streptococcus

    Grant number:18K08429  2018.4 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Kimura Kouji

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    Authorship:Principal investigator 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    It was revealed that carbapenem non-susceptible S. mitis / oralis has acquired multiple base substitutions with amino acid substitutions in the target molecule of carbapenem drugs, PBP genes . Interestingly, among those amino acid substitutions, some strains have amino acid substitutions in the conservative region of the transpeptidase domain of PBPs that forms the active site, where β-lactam antibiotics are expected to bind.
    In addition, the introduction of the mutant PBP gene into the S. mitis / oralis standard strain increased the minimum inhibitory concentration of β-lactams, and thus It became clear that the mutation of the PBP gene confer toreduced β-lactams susceptibility.

  7. Characterization of IMP-1, a major carbapenem resistance factor in bacteria

    Grant number:15H04868  2015.4 - 2018.3

    Arakawa Yoshichika

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

    Emerging of drug-resistant bacteria is a major clinical concern. Thus, it is essential to develop new antibiotics and agents to overcome the problem of drug-resistant bacteria. To respond to the aforementioned urgent and unmet needs, we have screened for metallo-beta-lactamase (MBL) inhibitor. MBL inhibitor can revive the efficacy of carbapenem antibiotics. We have screened 2107 small molecule compounds to identify IMP-1 inhibitor, IMP-1 is the dominant MBL in clinically isolated Enterobacteriaceae. Enzymatic and biological analyses revealed that 8 compounds would be candidates of IMP-1 inhibitor. These 8 compounds would be a great help to overcome carbapenem resistance caused by production of IMP-type MBL.

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Industrial property rights 2

  1. B群連鎖球菌を検出するためのプライマーセット及びその利用

    荒川宜親、木村幸司、柳沢英二

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    Patent/Registration no:5153726  Date registered:2012.12 

    Country of applicant:Domestic  

  2. ペニシリン耐性B群連鎖球菌(GroupBstreptococcus)を識別する方法及び識別用キット

    木村幸司、黒川博史、荒川宜親

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    Application no:2006−190059  Date applied:2006.7

    Patent/Registration no:特許第4956721号  Date registered:2012.3 

    Country of applicant:Domestic  

 

Teaching Experience (On-campus) 9

  1. 基礎医学セミナー

    2021

  2. ベーシックトレーニング

    2021

  3. 生体と微生物

    2021

  4. 自然環境と人間

    2021

  5. 修士必須科目講義

    2021

  6. ベーシックトレーニング

    2020

  7. 基礎医学セミナー

    2020

  8. 修士必須科目講義

    2020

  9. 生体と微生物

    2020

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