Organization
Nagoya University Hospital Anesthesiology Lecturer of hospital
Title
Lecturer of hospital
External link
HIRAI Takahiro
Degree 2
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学位（医学） （ 2022.12 名古屋大学 ）
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学士(医学) （ 2007.3 福井大学 ）
Research Areas 2
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Others / Others / Intensive care
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Others / Others / anesthesiology
Education 1
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University of Fukui Faculty of Medicine
- 2007.3
Country： Japan
Professional Memberships 4
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日本麻酔科学会
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集中治療医学会
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Japanese Society of Cardiovaslcular Anesthesiolosists
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医療の質・安全学会
2019.10
Papers 11
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Timing of onset of intraoperative transfusion anaphylaxis: a literature review
Amano, Y; Fujii, T; Tamura, T; Hirai, T; Nishiwaki, K
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 86 ( 3 ) page： 351 - 360 2024.8
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Tamura, T; Suzuki, S; Fujii, T; Hirai, T; Imaizumi, T; Kubo, Y; Shibata, Y; Narita, Y; Mutsuga, M; Nishiwaki, K
GENERAL THORACIC AND CARDIOVASCULAR SURGERY Vol. 72 ( 1 ) page： 15 - 23 2024.1
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Fujii, T; Hirai, T; Tamura, T; Suzuki, S; Nishiwaki, K
ARTIFICIAL ORGANS Vol. 47 ( 6 ) page： 982 - 989 2023.6
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Fujii, T; Hirai, T; Suzuki, S; Nishiwaki, K
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA Vol. 36 ( 3 ) page： 840 - 846 2022.3
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Differential effects of sevoflurane on the growth and apoptosis of human cancer cell lines.
Hirai T, Konishi Y, Mizuno S, Rui Z, Sun Y, Nishiwaki K
Journal of anesthesia Vol. 34 ( 1 ) page： 47 - 57 2020.2
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Differential effects of sevoflurane on the growth and apoptosis of human cancer cell lines (vol 77, pg 81, 2020)
Hirai Takahiro, Konishi Yuko, Mizuno Shoko, Rui Zhou, Sun Yao, Nishiwaki Kimitoshi
JOURNAL OF ANESTHESIA Vol. 34 ( 1 ) page： 58 - 58 2020.2
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Differential effects of sevoflurane on the growth and apoptosis of human cancer cell lines
Hirai Takahiro, Konishi Yuko, Mizuno Shoko, Rui Zhou, Sun Yao, Nishiwaki Kimitoshi
JOURNAL OF ANESTHESIA Vol. 34 ( 1 ) page： 47 - 57 2020.2
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Differential effects of sevoflurane on the growth and apoptosis of human cancer cell lines
Hirai Takahiro, Konishi Yuko, Mizuno Shoko, Rui Zhou, Sun Yao, Nishiwaki Kimitoshi
JOURNAL OF ANESTHESIA Vol. 34 ( 1 ) page： 47 - 57 2020.2
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Correction to: Differential effects of sevoflurane on the growth and apoptosis of human cancer cell lines.
Hirai T, Konishi Y, Mizuno S, Rui Z, Sun Y, Nishiwaki K
Journal of anesthesia Vol. 34 ( 1 ) page： 58 2020.2
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Differential effects of sevoflurane on the growth and apoptosis of human cancer cell lines (vol 77, pg 81, 2020)
Hirai Takahiro, Konishi Yuko, Mizuno Shoko, Rui Zhou, Sun Yao, Nishiwaki Kimitoshi
JOURNAL OF ANESTHESIA 2019.12
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Rhabdomyolysis due to propofol infusion syndrome after aortic surgery: a case report Reviewed
Takahiro Hirai, Motoshi Kainuma, Tomoko Hayashi, Kazuko Hasegawa, Tadashi Aoyama, Shoko Mizuno, Shogo Suzuki, Kimitoshi Nishiwaki
Vol. 23 ( 6 ) page： 647-650 2016.11
Presentations 1
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1% Sevoflurane exposure is associated with early and late apoptotic cell death on some cancer cell lines International conference
Yuko Konishi, Kimitoshi Nishiwaki
ANESTHESIOLOGY annual meeting 2018
KAKENHI (Grants-in-Aid for Scientific Research) 2
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Volatile anesthesia induced angiogenesis with cehmocine transcription
Grant number：19K09349 2019.4 - 2024.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Hirai Takahiro
Authorship：Principal investigator
Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）
Since volatile anesthesia is widely used for surgical tumor resection, the influence of preoperative anesthesia on tumor metastasis should be carefully examined. We have found that sevoflurane induces angiogenesis in tumors within immune-deficient xenograft models in mice. The cause of the induction of distant blood vessels could be attributed to chemokine or immune responses expressed by sevoflurane-exposed injected cancer cells. In this study, we found that chemokines and related immune signals were confirmed to be expressed in sevoflurane-exposed intestinal human cancer cells. However, in the in vitro model, neither methylation at the chemokine promoter area nor chemotaxis was detected using Western blotting and Boyden chamber assays, respectively.
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Evaluation of combined exposure of sevoflurane and anti cancer drugs
Grant number：15K15569 2015.4 - 2019.3
Hirai Takahiro
Authorship：Principal investigator
Grant amount：\3640000 （ Direct Cost: \2800000 、 Indirect Cost：\840000 ）
Some of anticancer drugs which mimic DNA component were taken to cancer cell when the cells were in cell cycle progression. To date we have investigated some of cancer cells were slightly increased cell population accompanied with DNA replication. Whereas our continuous study with this theme, we found that sevoflurane exposed cells that cultured with anti-cancer drug for 24 hours did not show significant reduction compared with anti cancer single treatment control.