Updated on 2024/04/02

写真a

 
NISHIMURA Yusuke
 
Organization
Graduate School of Medicine Program in Integrated Medicine Clinical Neurosciences Associate professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Associate professor
Contact information
メールアドレス

Degree 1

  1. 医学博士 ( 2013.1   名古屋大学 ) 

Research History 1

  1. Department of Neurosurgery, Nagoya University, Nagoya, Japan   Department of Neurosurgery   Lecturer

    2015.4

      More details

    Country:Japan

Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    - 2011.3

      More details

    Country: Japan

  2. Nagoya University   Faculty of Medicine

    - 2001.3

      More details

    Country: Japan

Professional Memberships 4

  1. 脳神経外科コングレス

  2. 脊髄障害医学会

  3. 日本脊髄外科学会

  4. 脳神経外科学会

 

Papers 89

  1. Protective Mechanism of Stem Cells from Human Exfoliated Deciduous Teeth in Treating Spinal Cord Injury

    Nishii, T; Osuka, K; Nishimura, Y; Ohmichi, Y; Ohmichi, M; Suzuki, C; Nagashima, Y; Oyama, T; Abe, T; Kato, H; Saito, R

    JOURNAL OF NEUROTRAUMA     2024.1

     More details

  2. Primary Bone Lymphoma of the Spine: A Case Report Highlighting Diagnostic Complexities and Treatment

    Tsukamoto, E; Nagashima, Y; Nishimura, Y; Kuwabara, K; Saito, R

    CUREUS JOURNAL OF MEDICAL SCIENCE   Vol. 16 ( 1 ) page: e52524   2024.1

     More details

  3. Efficacy of intraoperative irrigation with artificial cerebrospinal fluid in chronic subdural hematoma surgery: study protocol for a multicenter randomized controlled trial

    Nagashima, Y; Araki, Y; Nishida, K; Kuramitsu, S; Wakabayashi, K; Shimato, S; Kinkori, T; Nishizawa, T; Kano, T; Hasegawa, T; Noda, A; Maeda, K; Yamamoto, Y; Suzuki, O; Koketsu, N; Okada, T; Iwasaki, M; Nakabayashi, K; Fujitani, S; Maki, H; Kuwatsuka, Y; Nishihori, M; Tanei, T; Nishikawa, T; Nishimura, Y; Saito, R

    TRIALS   Vol. 25 ( 1 ) page: 6   2024.1

     More details

  4. Hemifacial spasm caused by multiple vascular attachments due to remote compression effects of a dermoid cyst in the cerebellar hemisphere: illustrative case.

    Hirayama K, Tanei T, Kato T, Hasegawa T, Ito E, Nishimura Y, Saito R

    Journal of neurosurgery. Case lessons   Vol. 6 ( 23 )   2023.12

     More details

    Language:English  

    DOI: 10.3171/CASE23592

    PubMed

  5. Lateral Lumbar Interbody Fusion within Three-level for Patients with Neurological Symptoms due to Vertebral Fragility Fractures in the Lumbar Spine

    Nagashima, Y; Nishimura, Y; Kanemura, T; Hata, N; Satake, K; Akahori, S; Ishii, M; Anei, T; Akayasu, M; Saito, R

    NEUROLOGIA MEDICO-CHIRURGICA   Vol. 63 ( 12 ) page: 548 - 554   2023.12

     More details

  6. Development of machine learning models for predicting unfavorable functional outcomes from preoperative data in patients with chronic subdural hematomas

    Fuse, Y; Nagashima, Y; Nishiwaki, H; Ohka, F; Muramatsu, Y; Araki, Y; Nishimura, Y; Ienaga, J; Nagatani, T; Seki, Y; Watanabe, K; Ohno, K; Saito, R

    SCIENTIFIC REPORTS   Vol. 13 ( 1 ) page: 16997   2023.10

     More details

  7. Comparative Study of Surgical Outcomes of Occipitocervical and Atlantoaxial Fusion for Retro-Odontoid Pseudotumor

    Nishii, T; Nishimura, Y; Nagashima, Y; Tanei, T; Hara, M; Takayasu, M; Kanemura, T; Saito, R

    WORLD NEUROSURGERY   Vol. 178   page: E230 - E238   2023.10

     More details

  8. Efficacy of the latest new stimulation patterns of spinal cord stimulation for intractable neuropathic pain compared to conventional stimulation: study protocol for a clinical trial

    Tanei, T; Maesawa, S; Nishimura, Y; Nagashima, Y; Ishizaki, T; Ando, M; Kuwatsuka, Y; Hashizume, A; Kurasawa, S; Saito, R

    TRIALS   Vol. 24 ( 1 ) page: 604   2023.9

     More details

  9. Surgical Outcomes of Common Peroneal Nerve Entrapment Neuropathy Associated with L5 Radiculopathy

    Ishii, M; Nishimura, Y; Hara, M; Yamamoto, Y; Nagashima, Y; Tanei, T; Takayasu, M; Saito, R

    NEUROLOGIA MEDICO-CHIRURGICA   Vol. 63 ( 8 ) page: 350 - 355   2023.8

     More details

  10. Direct Screw Osteosynthesis for an Elderly Osteoporotic Patient With C2 Complex Fracture

    Nagashima, Y; Nishimura, Y; Matsuo, M; Tanei, T; Saito, R

    CUREUS JOURNAL OF MEDICAL SCIENCE   Vol. 15 ( 7 ) page: e42510   2023.7

     More details

  11. Differential target multiplexed spinal cord stimulation using a paddle-type lead placed at the appropriate site for neuropathic pain after spinal cord injury in patients with past spinal surgical histories: study protocol for an exploratory clinical trial

    Tanei, T; Maesawa, S; Nishimura, Y; Nagashima, Y; Ishizaki, T; Ando, M; Kuwatsuka, Y; Hashizume, A; Kurasawa, S; Saito, R

    TRIALS   Vol. 24 ( 1 ) page: 395   2023.6

     More details

  12. Secondary aneurysmal bone cyst of the frontal bone with fibrous dysplasia showing rapid expansion: a case report

    Koketsu, Y; Tanei, T; Kuwabara, K; Hasegawa, T; Kato, T; Maesawa, S; Nishimura, Y; Araki, Y; Saito, R

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 85 ( 2 ) page: 395 - 401   2023.5

     More details

  13. Radiographic Prediction of the Occipito-C2 Angle Variation with Changes in Distance between the Mandible and Cervical Vertebrae: A Preliminary Study

    Nagashima, Y; Nishimura, Y; Awaya, T; Hata, N; Tanei, T; Ishii, M; Oyama, T; Nishii, T; Fukaya, N; Abe, T; Kato, H; Saito, R

    NEUROLOGIA MEDICO-CHIRURGICA   Vol. 63 ( 5 ) page: 200 - 205   2023.5

     More details

  14. Erratum (vol 63, pg 158, 2023)

    Yoshikawa, S; Nishimura, Y; Nagashima, Y; Ito, H; Oyama, T; Nishii, T; Gonda, T; Ryu, H; Nomura, K; Hara, M; Takayasu, M; Ginsberg, HJ; Kanemura, T; Saito, R

    NEUROLOGIA MEDICO-CHIRURGICA   Vol. 63 ( 5 ) page: 220 - 220   2023.5

  15. Evaluation of Posterior Ligamentous Complex Injury in Thoracolumbar Burst Fractures: Correlation Analysis of CT and MRI Findings

    Yoshikawa, S; Nishimura, Y; Nagashima, Y; Ito, H; Oyama, T; Nishii, T; Gonda, T; Ryu, H; Nomura, K; Hara, M; Takayasu, M; Ginsberg, HJ; Kanemura, T; Saito, R

    NEUROLOGIA MEDICO-CHIRURGICA   Vol. 63 ( 4 ) page: 158 - 164   2023.4

     More details

  16. Butterfly needle tap and suction (BTS) technique: a treatment for recurrent chronic subdural hematoma after burr hole craniostomy

    Yamamoto, S; Nagashima, Y; Maki, H; Nishimura, Y; Araki, Y; Nishihori, M; Noda, T; Imai, T; Kawabata, T; Ueno, M; Nishida, Y; Saito, R

    ACTA NEUROCHIRURGICA   Vol. 165 ( 4 ) page: 841 - 848   2023.4

     More details

  17. Comparative Study of Anterior Transvertebral Foraminotomy and Anterior Cervical Discectomy and Fusion for Unilateral Cervical Spondylotic Radiculopathy

    Akahori, S; Nishimura, Y; Eguchi, K; Nagashima, Y; Ando, R; Awaya, T; Tanei, T; Hara, M; Kanemura, T; Takayasu, M; Saito, R

    WORLD NEUROSURGERY   Vol. 171   page: E516 - E523   2023.3

     More details

  18. The usefulness of three-dimensional fusion imaging of spinal arteriovenous malformation by a workstation connected to angiography systems

    Nagashima, Y; Izumi, T; Nishimura, Y; Nishihori, M; Oyama, T; Matsuo, M; Ito, H; Nishii, T; Saito, R

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 85 ( 1 ) page: 127 - 133   2023.2

     More details

  19. Unique vascular structures of a radicular arteriovenous fistula at the craniocervical junction along the first cervical spinal nerve: A case report.

    Wada K, Tanei T, Hattori K, Hatano H, Fujitani S, Ito R, Kubo H, Nishimura Y, Maesawa S, Saito R

    Surgical neurology international   Vol. 14   page: 85   2023

     More details

    Language:English  

    DOI: 10.25259/SNI_122_2023

    PubMed

  20. Sacral arteriovenous fistula with lower thoracic cord edema without perimedullary vein enlargement.

    Ishii M, Nishimura Y, Nagashima Y, Tanei T, Nishihori M, Izumi T, Saito R

    Surgical neurology international   Vol. 14   page: 295   2023

     More details

    Language:English  

    DOI: 10.25259/SNI_606_2023

    PubMed

  21. Relief of Central Poststroke Pain Affecting Both the Arm and Leg on One Side by Double-independent Dual-lead Spinal Cord Stimulation Using Fast-acting Subperception Therapy Stimulation: A Case Report.

    Tanei T, Maesawa S, Nishimura Y, Nagashima Y, Ishizaki T, Mutoh M, Ito Y, Saito R

    NMC case report journal   Vol. 10   page: 15 - 20   2023

     More details

    Language:English  

    DOI: 10.2176/jns-nmc.2022-0336

    PubMed

  22. Efficacy of Spinal Cord Stimulation Using Differential Target Multiplexed Stimulation for Intractable Pain of Hereditary Neuropathy with Liability to Pressure Palsies: A Case Report.

    Tanei T, Nishimura Y, Nagashima Y, Ishii M, Nishii T, Fukaya N, Abe T, Kato H, Maesawa S, Saito R

    NMC case report journal   Vol. 10   page: 203 - 208   2023

     More details

    Language:English  

    DOI: 10.2176/jns-nmc.2023-0023

    PubMed

  23. Magnetic Resonance Imaging Scans of Cervical Spinal Cord Ependymoma with Changing Radiological Features over a Short Period of Time

    Nagashima, Y; Nishimura, Y; Saito, R

    WORLD NEUROSURGERY   Vol. 167   page: 95 - 97   2022.11

     More details

  24. True Angina Pectoris Immediately After Cervical Disc Herniation Surgery for Preoperative Cervical Angina Symptoms: A Case Report

    Abe, T; Tanei, T; Nishimura, Y; Saito, R

    CUREUS JOURNAL OF MEDICAL SCIENCE   Vol. 14 ( 8 ) page: e28313   2022.8

     More details

  25. Spontaneous regression of asymptomatic tumefactive perivascular spaces in the anterior temporal lobe

    Hashida, M; Nagashima, Y; Nishimura, Y; Eguchi, K; Taoka, T; Kawai, H; Saito, R

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 3 ) page: 678 - 685   2022.8

     More details

  26. Patient factors influencing a delay in diagnosis in pediatric spinal cord tumors

    Koshimizu, H; Nakashima, H; Ando, K; Kobayashi, K; Nishimura, Y; Machino, M; Ito, S; Kanbara, S; Inoue, T; Yamaguchi, H; Segi, N; Tomita, H; Imagama, S

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 3 ) page: 516 - 525   2022.8

     More details

  27. Radiological Analysis of Minimally Invasive Microscopic Laminectomy for Lumbar Canal Stenosis with a Focus on Multilevel Stenosis and Spondylolisthesis

    Awaya, T; Nishimura, Y; Eguchi, K; Nagashima, Y; Ando, R; Akahori, S; Yoshikawa, S; Haimoto, S; Hara, M; Takayasu, M; Saito, R

    WORLD NEUROSURGERY   Vol. 164   page: E224 - E234   2022.8

     More details

  28. Pure extraosseous spinal epidural cavernous hemangioma presenting with acute paraplegia: a case report

    Eguchi, K; Malhotra, AR; Malhotra, AK; Harrington, EM; Munoz, DG; Nishimura, Y; Wilson, JR; Witiw, CD

    SPINAL CORD SERIES AND CASES   Vol. 8 ( 1 ) page: 63   2022.6

     More details

  29. Changes in cerebral blood flow in the postoperative chronic phase after combined cerebral revascularization for moyamoya disease with ischaemic onset

    Araki, Y; Mamiya, T; Fujita, N; Uda, K; Yokoyama, K; Kanamori, F; Takayanagi, K; Ishii, K; Nishihori, M; Takeuch, K; Tanahashi, K; Nagata, Y; Nishimura, Y; Tanei, T; Sumitomo, M; Okamoto, S; Izumi, T; Kato, K; Saito, R

    NEUROSURGICAL REVIEW   Vol. 45 ( 3 ) page: 2471 - 2480   2022.6

     More details

  30. Recent Molecular and Genetic Findings in Intramedullary Spinal Cord Tumors

    Nagashima, Y; Nishimura, Y; Eguchi, K; Yamaguchi, J; Haimoto, S; Ohka, F; Takayasu, M; Saito, R

    NEUROSPINE   Vol. 19 ( 2 ) page: 262 - 271   2022.6

     More details

  31. Challenging direct bypass surgery for very young children with moyamoya disease: technical notes

    Araki, Y; Uda, K; Yokoyama, K; Kanamori, F; Kurimoto, M; Shiba, Y; Mamiya, T; Nishihori, M; Takeuchi, K; Tanahashi, K; Nagata, Y; Nishimura, Y; Okamoto, S; Sumitomo, M; Izumi, T; Saito, R

    NEUROSURGICAL REVIEW   Vol. 45 ( 2 ) page: 1799 - 1807   2022.4

     More details

  32. Risk Factors for Cerebral Infarction Early After Revascularization in Children Younger than 5 Years with Moyamoya Disease

    Araki, Y; Uda, K; Yokoyama, K; Kanamori, F; Kurimoto, M; Shiba, Y; Mamiya, T; Nishihori, M; Takeuchi, K; Tanahashi, K; Nagata, Y; Nishimura, Y; Okamoto, S; Sumitomo, M; Izumi, T; Saito, R

    WORLD NEUROSURGERY   Vol. 160   page: E220 - E226   2022.4

     More details

  33. Spatially separate cerebral infarction in the posterior cerebral artery territory after combined revascularization of the middle cerebral artery territory in an adult patient with moyamoya disease and fetal-type posterior communicating artery: illustrative case.

    Araki Y, Yokoyama K, Uda K, Kanamori F, Mamiya T, Takayanagi K, Ishii K, Nishihori M, Takeuchi K, Tanahashi K, Nagata Y, Tanei T, Nishimura Y, Izumi T, Saito R

    Journal of neurosurgery. Case lessons   Vol. 3 ( 12 )   2022.3

     More details

    Language:English  

    DOI: 10.3171/CASE21704

    PubMed

  34. Paradoxical symptomatic cerebral blood flow decreases after combined revascularization surgery for patients with pediatric moyamoya disease: illustrative case.

    Araki Y, Yokoyama K, Uda K, Kanamori F, Kurimoto M, Shiba Y, Mamiya T, Takayanagi K, Ishii K, Nishihori M, Takeuchi K, Tanahashi K, Nagata Y, Nishimura Y, Okamoto S, Sumitomo M, Izumi T, Saito R

    Journal of neurosurgery. Case lessons   Vol. 3 ( 3 )   2022.1

     More details

    Language:English  

    DOI: 10.3171/CASE21628

    PubMed

  35. Unilateral laminotomy for bilateral decompression and balloon kyphoplasty to decompress lumber canal stenosis aggravated by osteoporotic vertebral compression fractures: A technical note.

    Nagashima Y, Nishimura Y, Ishii M, Nishii T, Fukaya N, Oyama T, Abe T, Kato H, Tsukamoto E, Tanei T, Saito R

    Surgical neurology international   Vol. 13   page: 538   2022

     More details

    Language:English  

    DOI: 10.25259/SNI_971_2022

    PubMed

  36. Atypical radiographic case of arachnoid web without scalpel sign.

    Nagashima Y, Nishimura Y, Ito H, Oyama T, Nishii T, Gonda T, Kato H, Saito R

    Surgical neurology international   Vol. 13   page: 108   2022

     More details

    Language:English  

    DOI: 10.25259/SNI_179_2022

    PubMed

  37. Diagnosis and Treatment Strategies for Arachnoiditis Ossificans Following Subarachnoid Hemorrhage: A Case Report.

    Nagashima Y, Nishimura Y, Ito H, Nishii T, Oyama T, Saito R

    NMC case report journal   Vol. 9   page: 295 - 299   2022

     More details

    Language:English  

    DOI: 10.2176/jns-nmc.2022-0036

    PubMed

  38. Downward penetrating endplate screw technique under O-arm navigation posterior fusion in patients with osteoporotic vertebral body fractures associated with diffuse idiopathic skeletal hyperostosis.

    Shiraishi D, Yamamoto Y, Motonori I, Nishimura Y, Hara M, Saito R, Takayasu M

    Surgical neurology international   Vol. 13   page: 436   2022

     More details

    Language:English  

    DOI: 10.25259/SNI_762_2022

    PubMed

  39. Laminectomy triggers symptomatic growth of spinal schwannoma in a patient with schwannomatosis.

    Oyama T, Nishimura Y, Nagashima Y, Nishii T, Hara M, Takayasu M, Sakakibara A, Saito R

    Surgical neurology international   Vol. 13   page: 261   2022

     More details

    Language:English  

    DOI: 10.25259/SNI_453_2022

    PubMed

  40. Spinal Cord Stimulation for Neuropathic Pain following a Spinal Cord Lesion with Past Spinal Surgical Histories Using a Paddle Lead Placed on the Rostral Side of the Lesion: Report of Three Cases.

    Fukaya N, Tanei T, Nishimura Y, Hara M, Hata N, Nagashima Y, Maesawa S, Araki Y, Saito R

    NMC case report journal   Vol. 9   page: 349 - 355   2022

     More details

    Language:English  

    DOI: 10.2176/jns-nmc.2022-0218

    PubMed

  41. The preoperative focal cerebral blood flow status may be associated with slow flow in the bypass graft after combined surgery for moyamoya disease.

    Araki Y, Yokoyama K, Uda K, Kanamori F, Mamiya T, Takayanagi K, Ishii K, Shintai K, Nishihori M, Tsukada T, Takeuchi K, Tanahashi K, Nagata Y, Nishimura Y, Tanei T, Nagashima Y, Muraoka S, Izumi T, Seki Y, Saito R

    Surgical neurology international   Vol. 13   page: 511   2022

     More details

    Language:English  

    DOI: 10.25259/SNI_772_2022

    PubMed

  42. Two cases of solitary fibrous tumor/hemangiopericytoma with different clinical features according to the World Health Organization classification: case report and review of the literature.

    Nishii T, Nagashima Y, Nishimura Y, Ito H, Oyama T, Matsuo M, Sakakibara A, Shimada S, Saito R

    Journal of spine surgery (Hong Kong)   Vol. 7 ( 4 ) page: 532 - 539   2021.12

     More details

    Language:English  

    DOI: 10.21037/jss-21-83

    PubMed

  43. Clinical and Radiological Clues of Traumatic Craniocervical Junction Injuries Requiring Occipitocervical Fusion to Early Diagnosis

    Shiraishi, D; Nishimura, Y; Aguirre-Carreno, I; Hara, M; Yoshikawa, S; Eguchi, K; Nagashima, Y; Ito, H; Haimoto, S; Yamamoto, Y; Ginsberg, HJ; Takayasu, M; Saito, R

    NEUROSPINE   Vol. 18 ( 4 ) page: 741 - 748   2021.12

     More details

  44. Piecemeal resection of aggressive vertebral hemangioma using real-time navigation-guided drilling technique

    Nagashima, Y; Nishimura, Y; Haimoto, S; Eguchi, K; Awaya, T; Ando, R; Akahori, S; Hara, M; Natsume, A

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 4 ) page: 861 - 868   2021.11

     More details

  45. Driver Genetic Mutations in Spinal Cord Gliomas Direct the Degree of Functional Impairment in Tumor-Associated Spinal Cord Injury

    Nagashima, Y; Nishimura, Y; Ohka, F; Eguchi, K; Aoki, K; Ito, H; Nishii, T; Oyama, T; Hara, M; Kitano, Y; Masaki, H; Wakabayashi, T; Natsume, A

    CELLS   Vol. 10 ( 10 )   2021.10

     More details

  46. Neurosurgical versus endovascular treatment of spinal dural arteriovenous fistulas: a multicenter study of 195 patients

    Takai, K; Endo, T; Yasuhara, T; Seki, T; Watanabe, K; Tanaka, Y; Kurokawa, R; Kanaya, H; Honda, F; Itabashi, T; Ishikawa, O; Murata, H; Tanaka, T; Nishimura, Y; Eguchi, K; Takami, T; Watanabe, Y; Nishida, T; Hiramatsu, M; Ohtonari, T; Yamaguchi, S; Mitsuhara, T; Matsui, S; Uchikado, H; Hattori, G; Yamahata, H; Taniguchi, M

    JOURNAL OF NEUROSURGERY-SPINE   Vol. 34 ( 3 ) page: 514 - 521   2021.3

     More details

  47. <i>Neurod4</i> converts endogenous neural stem cells to neurons with synaptic formation after spinal cord injury

    Fukuoka, T; Kato, A; Hirano, M; Ohka, F; Aoki, K; Awaya, T; Adilijiang, A; Sachi, M; Tanahashi, K; Yamaguchi, J; Motomura, K; Shimizu, H; Nagashima, Y; Ando, R; Wakabayashi, T; Lee-Liu, D; Larrain, J; Nishimura, Y; Natsume, A

    ISCIENCE   Vol. 24 ( 2 ) page: 102074   2021.2

     More details

  48. Direct Vertebral Artery Puncture During Open Surgery for the Endovascular Treatment of a Recurrent Vertebro-Vertebral Arteriovenous Fistula

    Ikezawa, M; Izumi, T; Nishihori, M; Nagashima, Y; Nishimura, Y; Tsukuda, T; Kropp, AE; Goto, S; Otsuka, T; Kato, N; Nakano, M

    WORLD NEUROSURGERY   Vol. 146   page: 166 - 170   2021.2

     More details

  49. Spontaneous Rupture of a Huge Presacral Tarlov Cyst Leading to Dramatic Neurologic Recovery

    Akahori, S; Nishimura, Y; Eguchi, K; Nagashima, Y; Ando, R; Awaya, T; Hara, M; Natsume, A

    WORLD NEUROSURGERY   Vol. 145   page: 306 - 310   2021.1

     More details

  50. Preoperative Intracranial Dissemination of Spinal Myxopapillary Ependymoma Attributed to Tumor Hemorrhage

    Awaya, T; Nishimura, Y; Eguchi, K; Nagashima, Y; Ando, R; Akahori, S; Yoshikawa, S; Haimoto, S; Hara, M; Natsume, A

    WORLD NEUROSURGERY   Vol. 145   page: 13 - 18   2021.1

     More details

  51. Postoperative Cervicothoracic Kyphosis Following Infantile Intramedullary Tumor Resection Accelerates Neurological Deterioration.

    Gonda T, Nagashima Y, Nishimura Y, Ito H, Nisii T, Oyama T, Hara M, Saito R

    NMC case report journal   Vol. 8 ( 1 ) page: 705 - 711   2021

     More details

    Language:English  

    DOI: 10.2176/nmccrj.cr.2021-0086

    PubMed

  52. Dayside Polar Cap Density Enhancements Formed During Substorms

    Goodwin, LV; Nishimura, Y; Coster, AJ; Zhang, S; Nishitani, N; Ruohoniemi, JM; Anderson, BJ; Zhang, QH

    JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS   Vol. 125 ( 10 )   2020.10

  53. Thoracic Disc Herniation Manifesting as Abdominal Pain Alone Associated with Thoracic Radiculopathy.

    Ishii M, Nishimura Y, Hara M, Eguchi K, Nagashima Y, Awaya T, Ando R, Haimoto S, Wakabayashi T

    NMC case report journal   Vol. 7 ( 4 ) page: 161 - 165   2020.9

     More details

    Language:English  

    DOI: 10.2176/nmccrj.cr.2019-0247

    PubMed

  54. Microsurgical versus endovascular treatment of spinal epidural arteriovenous fistulas with intradural venous drainage: a multicenter study of 81 patients

    Takai, K; Endo, T; Yasuhara, T; Seki, T; Watanabe, K; Tanaka, Y; Kurokawa, R; Kanaya, H; Honda, F; Itabashi, T; Ishikawa, O; Murata, H; Nishimura, Y; Eguchi, K; Takami, T; Watanabe, Y; Nishida, T; Hiramatsu, M; Ohtonari, T; Yamaguchi, S; Mitsuhara, T; Matsui, S; Uchikado, H; Hattori, G; Horie, N; Yamahata, H; Taniguchi, M

    JOURNAL OF NEUROSURGERY-SPINE   Vol. 33 ( 3 ) page: 381 - 391   2020.9

     More details

  55. Possible Double Crush Syndrome Caused by Iatrogenic Acquired Lumbosacral Epidermoid Tumor and Concomitant Sacral Tarlov Cyst.

    Nishimura Y, Hara M, Awaya T, Ando R, Eguchi K, Nagashima Y, Wakabayashi T, Ginsberg HJ

    NMC case report journal   Vol. 7 ( 4 ) page: 195 - 199   2020.9

     More details

    Language:English  

    DOI: 10.2176/nmccrj.cr.2019-0236

    PubMed

  56. Complete resection and untethering of the cervical and thoracic spinal dermal sinus tracts in adult patients

    Nishimura, Y; Hara, M; Natsume, A; Wakabayashi, T; Ginsberg, HJ

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 3 ) page: 567 - 577   2020.8

     More details

  57. Intraosseous Melanotic Schwannoma in the Sacrum Mimicking Primary Bone Tumor.

    Nagashima Y, Nishimura Y, Eguchi K, Awaya T, Yoshikawa S, Haimoto S, Wakabayashi T, Hara M

    NMC case report journal   Vol. 7 ( 3 ) page: 107 - 111   2020.7

     More details

    Language:English  

    DOI: 10.2176/nmccrj.cr.2019-0238

    PubMed

  58. [(9)How Can We Control the Growing Number of Lumbar Degenerative Diseases from the Perspective of Neurospine Surgeons?].

    Nishimura Y, Hara M, Wakabayashi T

    No shinkei geka. Neurological surgery   Vol. 47 ( 3 ) page: 261 - 270   2019.3

     More details

    Language:Japanese  

    DOI: 10.11477/mf.1436203932

    PubMed

  59. Surgical treatment of a thoracic ventral intradural arachnoid cyst associated with syringomyelia: case report.

    Haimoto S, Nishimura Y, Ginsberg HJ

    Journal of neurosurgery. Spine   Vol. 30 ( 2 ) page: 193 - 197   2019.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3171/2018.8.SPINE18223

    Web of Science

    PubMed

  60. Driving of strong nightside reconnection and geomagnetic activity by polar cap flows: Application to CME shocks and possibly other situations

    Lyons, LR; Gallardo-Lacourt, B; Zou, Y; Nishimura, Y; Anderson, P; Angelopoulos, V; Donovan, EF; Ruohoniemi, JM; Mitchell, E; Paxton, LJ; Nishitani, N

    JOURNAL OF ATMOSPHERIC AND SOLAR-TERRESTRIAL PHYSICS   Vol. 177   page: 73 - 83   2018.10

  61. Reduction in surgical site infection with suprafascial intrawound application of vancomycin powder in instrumented posterior spinal fusion: a retrospective case-control study

    Haimoto Shoichi, Schar Ralph T., Nishimura Yusuke, Hara Masahito, Wakabayashi Toshihiko, Ginsberg Howard J.

    JOURNAL OF NEUROSURGERY-SPINE   Vol. 29 ( 2 ) page: 193 - 198   2018.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3171/2017.12.SPINE17997

    Web of Science

    PubMed

  62. A novel high-sensitivity assay to detect a small fraction of mutant IDH1 using droplet digital PCR.

    Hirano M, Ohka F, Maeda S, Chalise L, Yamamichi A, Aoki K, Kato A, Tanahashi K, Motomura K, Nishimura Y, Hara M, Shinjo K, Kondo Y, Wakabayashi T, Natsume A

    Brain tumor pathology   Vol. 35 ( 2 ) page: 97 - 105   2018.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10014-018-0310-7

    Web of Science

    PubMed

  63. Hybrid Method of Transvertebral Foraminotomy Combined with Anterior Cervical Decompression and Fusion for Multilevel Cervical Disease.

    Yamamoto Y, Hara M, Nishimura Y, Haimoto S, Wakabayashi T

    Neurologia medico-chirurgica   Vol. 58 ( 3 ) page: 124 - 131   2018.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2176/nmc.oa.2017-0196

    Web of Science

    PubMed

  64. Flat Posterior Cranial Fossa Affects Outcomes of Microvascular Decompression for Trigeminal Neuralgia.

    Fukuoka T, Nishimura Y, Hara M, Nomura K, Ryu H, Yoshikawa S, Wakabayashi T

    World neurosurgery   Vol. 111   page: E519 - E526   2018.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.wneu.2017.12.114

    Web of Science

    PubMed

  65. Spreading Speed of Magnetopause Reconnection X-Lines Using Ground-Satellite Coordination

    Zou Ying, Walsh Brian M., Nishimura Yukitoshi, Angelopoulos Vassilis, Ruohoniemi J. Michael, McWilliams Kathryn A., Nishitani Nozomu

    GEOPHYSICAL RESEARCH LETTERS   Vol. 45 ( 1 ) page: 80-89   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/2017GL075765

    Web of Science

  66. Clinical and Radiological Outcomes of Microscopic Lumbar Foraminal Decompression: A Pilot Analysis of Possible Risk Factors for Restenosis

    Haimoto Shoichi, Nishimura Yusuke, Hara Masahito, Nakajima Yasuhiro, Yamamoto Yu, Ginsberg Howard J., Wakabayashi Toshihiko

    NEUROLOGIA MEDICO-CHIRURGICA   Vol. 58 ( 1 ) page: 49 - 58   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2176/nmc.oa.2017-0121

    Web of Science

    PubMed

  67. Wire Probe Antenna (WPT) and Electric Field Detector (EFD) of Plasma Wave Experiment (PWE) aboard the Arase satellite: specifications and initial evaluation results

    Kasaba Yasumasa, Ishisaka Keigo, Kasahara Yoshiya, Imachi Tomohiko, Yagitani Satoshi, Kojima Hirotsugu, Matsuda Shoya, Shoji Masafumi, Kurita Satoshi, Hori Tomoaki, Shinbori Atsuki, Teramoto Mariko, Miyoshi Yoshizumi, Nakagawa Tomoko, Takahashi Naoko, Nishimura Yukitoshi, Matsuoka Ayako, Kumamoto Atsushi, Tsuchiya Fuminori, Nomura Reiko

    EARTH PLANETS AND SPACE   Vol. 69   2017.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40623-017-0760-x

    Web of Science

  68. Common TFIIH recruitment mechanism in global genome and transcription-coupled repair subpathways

    Okuda Masahiko, Nakazawa Yuka, Guo Chaowan, Ogi Tomoo, Nishimura Yoshifumi

    NUCLEIC ACIDS RESEARCH   Vol. 45 ( 22 )   2017.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/nar/gkx970

    Web of Science

  69. Search for an Excess of Events in the Super-Kamiokande Detector in the Directions of the Astrophysical Neutrinos Reported by the IceCube Collaboration

    Abe K., Bronner C., Pronost G., Hayato Y., Ikeda M., Iyogi K., Kameda J., Kato Y., Kishimoto Y., Marti Ll., Miura M., Moriyama S., Nakahata M., Nakano Y., Nakayama S., Okajima Y., Orii A., Sekiya H., Shiozawa M., Sonoda Y., Takeda A., Takenaka A., Tanaka H., Tasaka S., Tomura T., Akutsu R., Kajita T., Kaneyuki K., Nishimura Y., Okumura K., Tsui K. M., Labarga L., Fernandez P., Blaszczyk F. D. M., Gustafson J., Kachulis C., Kearns E., Raaf J. L., Stone J. L., Sulak L. R., Berkman S., Tobayama S., Goldhaber M., Elnimr M., Kropp W. R., Mine S., Locke S., Weatherly P., Smy M. B., Sobel H. W., Takhistov V., Ganezer K. S., Hill J., Kim J. Y., Lim I. T., Park R. G., Himmel A., Li Z., O'Sullivan E., Scholberg K., Walter C. W., Ishizuka T., Nakamura T., Jang J. S., Choi K., Learned J. G., Matsuno S., Smith S. N., Amey J., Litchfield R. P., Ma W. Y., Uchida Y., Wascko M. O., Cao S., Friend M., Hasegawa T., Ishida T., Ishii T., Kobayashi T., Nakadaira T., Nakamura K., Oyama Y., Sakashita K., Sekiguchi T., Tsukamoto T., Abe K. E., Hasegawa M., Suzuki A. T., Takeuchi Y., Yano T., Cao S. V., Hayashino T., Hiraki T., Hirota S., Huang K., Jiang M., Minamino A., Nakamura K. E., Nakaya T., Quilain B., Patel N. D., Wendell R. A., Anthony L. H. V., McCauley N., Pritchard A., Fukuda Y., Itow Y., Murase M., Muto F., Mijakowski P., Frankiewicz K., Jung C. K., Li X., Palomino J. L., Santucci G., Vilela C., Wilking M. J., Yanagisawa C., Ito S., Fukuda D., Ishino H., Kibayashi A., Koshio Y., Nagata H., Sakuda M., Xu C., Kuno Y., Wark D., Di Lodovico F., Richards B., Tacik R., Kim S. B., Cole A., Thompson L., Okazawa H., Choi Y., Ito K., Nishijima K., Koshiba M., Totsuka Y., Suda Y., Yokoyama M., Calland R. G., Hartz M., Martens K., Simpson C., Suzuki Y., Vagins M. R., Hamabe D., Kuze M., Yoshida T., Ishitsuka M., Martin J. F., Nantais C. M., Tanaka H. A., Konaka A., Chen S., Wan L., Zhang Y., Minamino A., Wilkes R. J.

    ASTROPHYSICAL JOURNAL   Vol. 850 ( 2 )   2017.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3847/1538-4357/aa951b

    Web of Science

  70. Influence of Auroral Streamers on Rapid Evolution of Ionospheric SAPS Flows

    Gallardo-Lacourt Bea, Nishimura Y., Lyons L. R., Mishin E. V., Ruohoniemi J. M., Donovan E. F., Angelopoulos V., Nishitani N.

    JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS   Vol. 122 ( 12 ) page: 12406-12420   2017.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/2017JA024198

    Web of Science

  71. Diverse Nuclear Star-forming Activities in the Heart of NGC 253 Resolved with 10-pc-scale ALMA Images

    Ando Ryo, Nakanishi Kouichiro, Kohno Kotaro, Izumi Takuma, Martin Sergio, Harada Nanase, Takano Shuro, Kuno Nario, Nakai Naomasa, Sugai Hajime, Sorai Kazuo, Tosaki Tomoka, Matsubayashi Kazuya, Nakajima Taku, Nishimura Yuri, Tamura Yoichi

    ASTROPHYSICAL JOURNAL   Vol. 849 ( 2 )   2017.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3847/1538-4357/aa8fd4

    Web of Science

  72. Biallelic Mutations in KDSR Disrupt Ceramide Synthesis and Result in a Spectrum of Keratinization Disorders Associated with Thrombocytopenia

    Takeichi Takuya, Torrelo Antonio, Lee John Y. W., Ohno Yusuke, Luisa Lozano Maria, Kihara Akio, Liu Lu, Yasuda Yuka, Ishikawa Junko, Murase Takatoshi, Belen Rodrigo Ana, Fernandez-Crehuet Pablo, Toi Yoichiro, Mellerio Jemima, Rivera Jose, Vicente Vicente, Kelsell David P., Nishimura Yutaka, Okuno Yusuke, Kojima Daiei, Ogawa Yasushi, Sugiura Kazumitsu, Simpson Michael A., McLean W. H. Irwin, Akiyama Masashi, McGrath John A.

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   Vol. 137 ( 11 ) page: 2344-2353   2017.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jid.2017.06.028

    Web of Science

  73. Remote ischemic preconditioning protects human neural stem cells from oxidative stress

    Motomura Ayako, Shimizu Mikiko, Kato Akira, Motomura Kazuya, Yamamichi Akane, Koyama Hiroko, Ohka Fumiharu, Nishikawa Tomohide, Nishimura Yusuke, Hara Masahito, Fukuda Tetsuya, Bando Yasuhiko, Nishimura Toshihide, Wakabayashi Toshihiko, Natsume Atsushi

    APOPTOSIS   Vol. 22 ( 11 ) page: 1353 - 1361   2017.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10495-017-1425-8

    Web of Science

    PubMed

  74. Fast heating of fuel assembled in a spherical deuterated polystyrene shell target by counter-irradiating tailored laser pulses delivered by a HAMA 1 Hz ICF driver

    Mori Y., Nishimura Y., Hanayama R., Nakayama S., Ishii K., Kitagawa Y., Sekine T., Takeuchi Y., Kurita T., Satoh N., Kawashima T., Komeda O., Nishi T., Azuma H., Hioki T., Motohiro T., Sunahara A., Sentoku Y., Miura E.

    NUCLEAR FUSION   Vol. 57 ( 11 )   2017.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1088/1741-4326/aa7e4d

    Web of Science

  75. Surgical Treatment of Rotational Vertebral Artery Syndrome Induced by Spinal Tumor: A Case Report and Literature Review.

    Haimoto S, Nishimura Y, Hara M, Yamamoto Y, Fukuoka T, Fukuyama R, Wakabayashi T, Ginsberg HJ

    NMC case report journal   Vol. 4 ( 4 ) page: 101 - 105   2017.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2176/nmccrj.cr.2016-0152

    PubMed

  76. Chiari Type 1 Malformation-induced Intracranial Hypertension with Diffuse Brain Edema Treated with Foramen Magnum Decompression: A Case Report.

    Fukuoka T, Nishimura Y, Hara M, Haimoto S, Eguchi K, Yoshikawa S, Wakabayashi T, Ginsberg HJ

    NMC case report journal   Vol. 4 ( 4 ) page: 115 - 120   2017.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2176/nmccrj.cr.2016-0278

    PubMed

  77. The comparison of nasal surgery and CPAP on daytime sleepiness in patients with OSAS

    Tagaya Mitsuhiko, Otake Hironao, Suzuki Keisuke, Yasuma Fumihiko, Yamamoto Hiroshi, Noda Akiko, Nishimura Yoichi, Sone Michihiko, Nakashima Tsutomu, Nakata Seiichi

    RHINOLOGY   Vol. 55 ( 3 ) page: 269-273   2017.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4193/Rhino17.026

    Web of Science

  78. Gene Regulatory Networks for the Haploid-to-Diploid Transition of Chlamydomonas reinhardtii

    Joo Sunjoo, Nishimura Yoshiki, Cronmiller Evan, Hong Ran Ha, Kariyawasam Thamali, Wang Ming Hsiu, Shao Nai Chun, El Akkad Saif-El-Din, Suzuki Takamasa, Higashiyama Tetsuya, Jin Eonseon, Lee Jae-Hyeok

    PLANT PHYSIOLOGY   Vol. 175 ( 1 ) page: 314-332   2017.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1104/pp.17.00731

    Web of Science

  79. Comparing the Efficacy of DeVIC Therapy and High-dose Methotrexate Monotherapy with Whole-brain Radiation Therapy for Newly-diagnosed Primary Central Nervous System Lymphoma: A Single Institution Study

    Chalise Lushun, Motomura Kazuya, Ohka Fumiharu, Hirano Masaki, Hara Masahito, Nishimura Yusuke, Natsume Atsushi, Wakabayashi Toshihiko

    ANTICANCER RESEARCH   Vol. 37 ( 9 ) page: 5215 - 5223   2017.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.11945

    Web of Science

    PubMed

  80. Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly

    Shirai Atsuko, Kawaguchi Takayuki, Shimojo Hideaki, Muramatsu Daisuke, Ishida-Yonetani Mayumi, Nishimura Yoshifumi, Kimura Hiroshi, Nakayama Jun-ichi, Shinkai Yoichi

    ELIFE   Vol. 6   2017.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.7554/eLife.25317

    Web of Science

  81. Propagation and evolution of electric fields associated with solar wind pressure pulses based on spacecraft and ground-based observations

    Takahashi N., Kasaba Y., Nishimura Y., Shinbori A., Kikuchi T., Hori T., Ebihara Y., Nishitani N.

    JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS   Vol. 122 ( 8 ) page: 8446-8461   2017.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/2017JA023990

    Web of Science

  82. Search for nucleon decay into charged antilepton plus meson in 0.316 megaton . years exposure of the Super-Kamiokande water Cherenkov detector

    Abe K., Bronner C., Pronost G., Hayato Y., Ikeda M., Iyogi K., Kameda J., Kato Y., Kishimoto Y., Marti Ll., Miura M., Moriyama S., Nakahata M., Nakano Y., Nakayama S., Okajima Y., Orii A., Sekiya H., Shiozawa M., Sonoda Y., Takeda A., Takenaka A., Tanaka H., Tasaka S., Tomura T., Akutsu R., Kajita T., Kaneyuki K., Nishimura Y., Okumura K., Tsui K. M., Labarga L., Fernandez P., Blaszczyk F. d. M., Gustafson J., Kachulis C., Kearns E., Raaf J. L., Stone J. L., Sulak L. R., Berkman S., Tobayama S., Goldhaber M., Elnimr M., Kropp W. R., Mine S., Locke S., Weatherly P., Smy M. B., Sobel H. W., Takhistov V., Ganezer K. S., Hill J., Kim J. Y., Lim I. T., Park R. G., Himmel A., Li Z., O'Sullivan E., Scholberg K., Walter C. W., Ishizuka T., Nakamura T., Jang J. S., Choi K., Learned J. G., Matsuno S., Smith S. N., Amey J., Litchfield R. P., Ma W. Y., Uchida Y., Wascko M. O., Cao S., Friend M., Hasegawa T., Ishida T., Ishii T., Kobayashi T., Nakadaira T., Nakamura K., Oyama Y., Sakashita K., Sekiguchi T., Tsukamoto T., Abe K. E., Hasegawa M., Suzuki A. T., Takeuchi Y., Yano T., Hayashino T., Hiraki T., Hirota S., Huang K., Jiang M., Nakamura K. E., Nakaya T., Quilain B., Patel N. D., Wendell R. A., Anthony L. H. V., McCauley N., Pritchard A., Fukuda Y., Itow Y., Murase M., Muto F., Mijakowski P., Frankiewicz K., Jung C. K., Li X., Palomino J. L., Santucci G., Vilela C., Wilking M. J., Yanagisawa C., Ito S., Fukuda D., Ishino H., Kibayashi A., Koshio Y., Nagata H., Sakuda M., Xu C., Kuno Y., Wark D., Di Lodovico F., Richards B., Tacik R., Kim S. B., Cole A., Thompson L., Okazawa H., Choi Y., Ito K., Nishijima K., Koshiba M., Totsuka Y., Suda Y., Yokoyama M., Calland R. G., Hartz M., Martens K., Shimpson C., Suzuki Y., Vagins M. R., Martin J. F., Nantais C. M., Tanaka H. A., Konaka A., Chen S., Wan L., Zhang Y., Minamino A., Wilkes R. J.

    PHYSICAL REVIEW D   Vol. 96 ( 1 )   2017.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1103/PhysRevD.96.012003

    Web of Science

  83. Direct heating of a laser-imploded core using ultraintense laser LFEX

    Kitagawa Y., Mori Y., Ishii K., Hanayama R., Nishimura Y., Okihara S., Nakayama S., Sekine T., Takagi M., Watari T., Satoh N., Kawashima T., Komeda O., Hioki T., Motohiro T., Azuma H., Sunahara A., Sentoku Y., Arikawa Y., Abe Y., Miura E., Ozaki T.

    NUCLEAR FUSION   Vol. 57 ( 7 )   2017.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1088/1741-4326/aa70bc

    Web of Science

  84. A Quality Improvement Collaborative Program for Neonatal Pain Management in Japan

    Ozawa Mio, Yokoo Kyoko, Funaba Yuuki, Fukushima Sayo, Fukuhara Rie, Uchida Mieko, Aiba Satoru, Doi Miki, Nishimura Akira, Hayakawa Masahiro, Nishimura Yutaka, Oohira Mitsuko

    ADVANCES IN NEONATAL CARE   Vol. 17 ( 3 ) page: 184-191   2017.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/ANC.0000000000000382

    Web of Science

  85. Quantum Chemical Estimation of Acetone Physisorption on Graphene Using Combined Basis Set and Size Extrapolation Schemes

    Nishimura Yoshifumi, Tsuneda Takao, Sato Takeshi, Katouda Michio, Irle Stephan

    JOURNAL OF PHYSICAL CHEMISTRY C   Vol. 121 ( 16 ) page: 8999 - 9010   2017.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.jpcc.6b13002

    Web of Science

  86. A novel all-in-one intraoperative genotyping system for IDH1-mutant glioma

    Ohka Fumiharu, Yamamichi Akane, Kurimoto Michihiro, Motomura Kazuya, Tanahashi Kuniaki, Suzuki Hiromichi, Aoki Kosuke, Deguchi Shoichi, Chalise Lushun, Hirano Masaki, Kato Akira, Nishimura Yusuke, Hara Masahito, Kato Yukinari, Wakabayashi Toshihiko, Natsume Atsushi

    BRAIN TUMOR PATHOLOGY   Vol. 34 ( 2 ) page: 91 - 97   2017.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10014-017-0281-0

    Web of Science

    PubMed

  87. Localized polar cap precipitation in association with nonstorm time airglow patches

    Zou Ying, Nishimura Yukitoshi, Lyons Larry R., Shiokawa Kazuo

    GEOPHYSICAL RESEARCH LETTERS   Vol. 44 ( 2 ) page: 609-617   2017.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/2016GL071168

    Web of Science

  88. Search for proton decay via p -> e(+) pi(0) and p -> mu(+) pi(0) in 0.31 megaton center dot years exposure of the Super-Kamiokande water Cherenkov detector

    Abe K., Haga Y., Hayato Y., Ikeda M., Iyogi K., Kameda J., Kishimoto Y., Miura M., Moriyama S., Nakahata M., Nakajima T., Nakano Y., Nakayama S., Orii A., Sekiya H., Shiozawa M., Takeda A., Tanaka H., Tomura T., Wendell R. A., Akutsu R., Irvine T., Kajita T., Kaneyuki K., Nishimura Y., Richard E., Okumura K., Labarga L., Fernandez P., Gustafson J., Kachulis C., Kearns E., Raaf J. L., Stone J. L., Sulak L. R., Berkman S., Nantais C. M., Tanaka H. A., Tobayama S., Goldhaber M., Kropp W. R., Mine S., Weatherly P., Smy M. B., Sobel H. W., Takhistov V., Ganezer K. S., Hartfiel B. L., Hill J., Hong N., Kim J. Y., Lim I. T., Park R. G., Himmel A., Li Z., O'Sullivan E., Scholberg K., Walter C. W., Wongjirad T., Ishizuka T., Tasaka S., Jang J. S., Learned J. G., Matsuno S., Smith S. N., Friend M., Hasegawa T., Ishida T., Ishii T., Kobayashi T., Nakadaira T., Nakamura K., Oyama Y., Sakashita K., Sekiguchi T., Tsukamoto T., Suzuki A. T., Takeuchi Y., Yano T., Cao S. V., Hiraki T., Hirota S., Huang K., Kikawa T., Minamino A., Nakaya T., Suzuki K., Fukuda Y., Choi K., Itow Y., Suzuki T., Mijakowski P., Frankiewicz K., Hignight J., Imber J., Jung C. K., Li X., Palomino J. L., Wilking M. J., Yanagisawa C., Fukuda D., Ishino H., Kayano T., Kibayashi A., Koshio Y., Mori T., Sakuda M., Xu C., Kuno Y., Tacik R., Kim S. B., Okazawa H., Choi Y., Nishijima K., Koshiba M., Totsuka Y., Suda Y., Yokoyama M., Bronner C., Hartz M., Martens K., Marti Ll., Suzuki Y., Vagins M. R., Martin J. F., Konaka A., Chen S., Zhang Y., Wilkes R. J.

    PHYSICAL REVIEW D   Vol. 95 ( 1 )   2017.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1103/PhysRevD.95.012004

    Web of Science

  89. Development of Density-Functional Tight-Binding Repulsive Potentials for Bulk Zirconia using Particle Swarm Optimization Algorithm

    Hutama Aulia S., Nishimura Yoshifumi, Chou Chien-Pin, Irle Stephan

    PROCEEDINGS OF THE INTERNATIONAL CONFERENCE OF COMPUTATIONAL METHODS IN SCIENCES AND ENGINEERING 2017 (ICCMSE-2017)   Vol. 1906   2017

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1063/1.5012294

    Web of Science

▼display all

KAKENHI (Grants-in-Aid for Scientific Research) 4

  1. Development of a novel treatment for spinal cord injury combining spinal cord stimulation and dental pulp stem cells

    Grant number:23K08565  2023.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

      More details

    Authorship:Coinvestigator(s) 

  2. 塩基性ヘリックスループヘリックス転写機構制御と細胞治療を融合する神経再生治療開発

    Grant number:22K09280  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    西村 由介, 永島 吉孝, 夏目 敦至, 古橋 和拡

      More details

    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    申請者らは『損傷脊髄を完全に再生する驚異的な能力を持つアフリカツメガエル幼生期に強く発現し、脊髄再生に関わるNeurod4などの塩基性ヘリックスループヘリックス(bHLH)神経転写因子を歯髄幹細胞に遺伝子導入してラット脊髄損傷モデルに投与することで、歯髄幹細胞自体をニューロンへ分化させ神経回路を再構築し、神経栄養因子分泌による脊髄再生効果に相加的かつ加速度的な神経機能回復が得られる』という仮説を立て、これを実証する。
    ① bHLH神経転写因子の遺伝子導入、 in vitroでの神経栄養因子の測定:アフリカツメガエル幼生期に高発現している脊髄再生に関わるNeurod4(bHLH神経転写因子)をシュードウイルスベクターでSHED(ヒト由来歯髄幹細胞)に良好に遺伝子導入し(Neurod4-SHED)、ウエスタンブロットでNeurod4が発現されていることが確認できた。その後、in vitroで培養し、神経栄養因子の分泌(培養上清での測定)を測定し、Neurod4-SHEDをnaiveのSHEDと比較した結果、MCP-1、TGF-βが有意に上昇していることがつきとめられた。これらが炎症惹起するM1マクロファージより炎症抑制するM2マクロファージを活性化する機能を有するため、マクロファージの動態を解析することを現在行っている。
    ② ラットへのSHED投与、機能評価、組織学的解析:胸髄損傷ラットモデルを用い、SHEDを胸髄内に投与した。下肢運動機能スコア(BBBスコア)で良好な下肢の運動機能回復がnaiveのSHEDとの比較で有意差をもって確認された。
    ③ Neurod4-SHEDの造腫瘍性試験:Neurod4-SHEDを移植して8週間の時点では、ラットの健康状態には問題がなく、造腫瘍性も否定されている。
    基本的にはおおむね順調に進展しており、予測された通り遺伝子改変した歯髄幹細胞(Neurod4-SHED)を投与したラットでは有意な下肢運動機能改善が認められた。そのメカニズムの解析の第1段階として、神経栄養因子の分泌(培養上清での測定)を測定し、naiveのSHEDと比較した結果、MCP-1、TGF-βが有意に上昇していることがつきとめられた。これらが炎症惹起するM1マクロファージより炎症抑制するM2マクロファージを活性化する機能を有するため、現在マクロファージの動態の研究を進めているが、今のところウエスタンブロットではnaiveのSHEDと比較して、Neurod4-SHEDがM2マクロファージを有意に誘導することが証明できておらずやや時間を要している。
    マクロファージの動態に関しては、マクロファージとSHEDの共培養を行い、M2マクロファージがNeurod4-SHEDにより有意に誘導されることを証明する。また、Neurod4-SHEDマイクロアレイ解析を行うことにより、ラット運動機能の有意な改善に寄与した神経再生に関わる因子の同定を行う予定である。また、運動機能が改善したラット脊髄の病理学的な解析、損傷脊髄移植8週間後のNeurod4-SHEDの動態と分化の解析も行う。

  3. 脊髄損傷後の歯髄幹細胞治療の作用機序の解明と更なるadjuvant治療の確立

    Grant number:22K09269  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    大須賀 浩二, 西村 由介, 大道 美香, 大道 裕介, 宮地 茂

      More details

    Authorship:Coinvestigator(s) 

    脊髄損傷後の一次損傷は避けられないが、それに誘導される二次損傷を如何に軽減するのかが脊髄損傷後における治療課題である。神経外胚葉と間葉系幹細胞的性質を兼ね備えた歯髄幹細胞は脊髄損傷後において、機能予後の著しい改善が報告されてきた。しかし、その作用機序として、歯髄幹細胞からのパラクリン効果として、抗神経軸索伸長抑制効果があると報告されているが、in vivoレベルでの作用機序に関しては、まだ完全には解明されていない。本研究においては、脊髄損傷後における歯髄幹細胞によるシグナル伝達系への影響を探索し、抗神経軸索伸長抑制効果のメカニズムを明らかにする。
    脊髄損傷における神経外胚葉と間葉系幹細胞的性質を兼ね備えた歯髄幹細胞(SHED)の作用機序としては、抗神経軸索伸長抑制因子効果が報告されている。しかし、in vivoレベルでのその作用機序は、完全には解明されていない。今回我々は、歯髄幹細胞は如何に二次損傷を減少させることで機能予後に関与してきているのかを検証するため、クリップによるラット脊髄損傷モデルを用いて検討した。
    脊髄損傷モデル(SCI group)群、脊髄損傷+PBS投与(SCI+PBS group)群と脊髄損傷+SHED投与(SCI+SHED group)群においてBBS scoreにて機能評価を行なったところ、day7までは有意な差は認めなかったが、day14以降はSCI+SHED group群において有意な機能予後の改善を認めた。よって、day5と10におけるシグナル伝達系の発現において差があるのかどうか比較検討をおこなった。
    脊髄損傷部位におけるphosphorylated (p)-STAT3 at Tyr705の発現は、それぞれの群間でday5では変化を認めなかったが、day10においてはSCI+SHED group群において有意に発現の低下を認めた。iba-1ならびにGFAPの発現に関しても比較検討したが、day5では、いずれも変化を認めなかったが、day10においてはGFAPの発現がSCI+SHED groupにおいて有意に低下していた。
    また、免疫組織染色の結果から、p-STAT3 at Tyr705の発現は、GFAPと一致しており、reactiveなastrocyteにおいてp-STAT3 Tyrの活性化を抑えていることが判明した。
    以上の結果から、SHEDの機能予後改善においては、day10におけるastrocyteでのSTAT3活性化を抑制することによる可能性が強く示唆された。
    研究実績においても記載させていただきましたが、歯髄幹細胞(SHED)の脊髄損傷後の脊髄機能改善の一因として、Western blotならびに免疫組織染色の結果からreactiveなastrocyteでのp-STAT3 at Tyr705の活性化を抑制していることが判明した。これらの知見は、未だかつて報告されたこともなく、新たな結果を得ており、概ね順調に研究は進展していると判断します。今後も、引き続き新たな結果が得られるように更なる検討を加えていく予定です。
    今回得られた歯髄幹細胞(SHED)の脊髄損傷後の脊髄機能改善の一因として、day10においてreactiveなastrocyteでのp-STAT3 at Tyr705の活性化を抑制していることによる可能性が示唆されたが、何がSTAT3を活性化させるのかなど、そこに至るまでの作用機序について更なる検討を推進していく予定です。
    また、脊髄損傷後の歯髄幹細胞投与によるTGF-βを介するSmadへのシグナル伝達系への影響についても検討を推進していく予定です。
    以上の結果を踏まえ、STAT3やSmadのknockoutマウスを用いて、脊髄損傷モデルを作成する。下肢の動きなどBBBスコアーにて詳細に評価し、その後、歯髄幹細胞投与によるこれらのknockoutマウスでの治療効果に関して詳細に検討を加え、歯髄幹細胞の作用機序の解明を更に推進していく予定です。

  4. Neurod4 converts endogenous neural stem cells to neurons with synaptic formation after spinal cord injury

    Grant number:19K09453  2019.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Nishimura Yusuke

      More details

    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    The transcriptome analysis of injured Xenopus laevis tadpole and mice suggested that Neurod4L.S., a basic-helix-loop-helix transcription factor, was the most promising transcription factor to exert neuroregeneration after spinal cord injury (SCI) in mammals. We generated a pseudotyped retroviral vector with the neurotropic lymphocytic choriomeningitis virus (LCMV) envelope to deliver murine Neurod4 to mice undergoing SCI. SCI induced ependymal cells to neural stem cells (NSCs) in the central canal. The LCMV envelope-based pseudotypedvector preferentially introduced Neurod4 into activated NSCs, which converted to neurons with axonal regrowth and suppressed the scar-forming glial lineage. Neurod4-induced inhibitory neurons predominantly projected to the subsynaptic domains of motor neurons at the epicenter, and Neurod4-induced excitatory neurons predominantly projected to subsynaptic domains of motor neurons caudal to the injury site suggesting the formation of functional synapses.