Organization
Nagoya University Hospital Pediatrics Assistant professor of hospital
Title
Assistant professor of hospital
External link
FUKASAWA Yoshie
Degree 1
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学士(医学) （ 2000.3 名古屋大学 ）
Research Interests 1
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Pediatric cardiology
Research History 1
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名古屋大学医学部附属病院
2004.1 - 2004.9
Country：Japan
Professional Memberships 1
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日本人類遺伝学会 専門医
Papers 19
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Case report: High-dose epoprostenol therapy in pediatric patients with pulmonary hypertension and developmental lung disease Reviewed International journal
Fukasawa, Y; Yamamoto, H; Ito, M; Saito, A; Go, K; Morimoto, Y; Yasuda, K; Sato, Y; Hayakawa, M; Kato, T
FRONTIERS IN PEDIATRICS Vol. 11 page： 1116434 2023.3
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Dysbiosis of gut microbiota in patients with protein-losing enteropathy after the Fontan procedure Reviewed
Go, K; Horiba, K; Yamamoto, H; Morimoto, Y; Fukasawa, Y; Ohashi, N; Yasuda, K; Ishikawa, Y; Kuraishi, K; Suzuki, K; Ito, Y; Takahashi, Y; Kato, T
INTERNATIONAL JOURNAL OF CARDIOLOGY Vol. 396 page： 131554 2024.2
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Effects of General Anesthesia on the Results of Cardiac Catheterization in Pediatric Patients with Ventricular Septal Defect Reviewed International journal
Go, K; Kato, T; Kito, M; Morimoto, Y; Kawai, S; Yamamoto, H; Fukasawa, Y; Yasuda, K
CONGENITAL HEART DISEASE Vol. 18 ( 2 ) page： 235 - 243 2023.3
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Conception by assisted reproductive technology in infants with critical congenital heart disease in Japan Reviewed International journal
Morimoto, Y; Go, K; Yamamoto, H; Fukasawa, Y; Nakai, M; Morihana, E; Yasuda, K; Nishikawa, H; Ohashi, N; Takahashi, Y; Kato, T
REPRODUCTIVE BIOMEDICINE ONLINE Vol. 44 ( 1 ) page： 163 - 170 2022.1
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Tension hemothorax 1 week after pericardiocentesis associated with thrombocytopenia Reviewed
Yamamoto, H; Go, K; Morimoto, Y; Fukasawa, Y; Kato, T
PEDIATRICS INTERNATIONAL Vol. 64 ( 1 ) page： e15395 2022.1
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Echocardiography Monitoring of Pulmonary Hypertension after Pediatric Hematopoietic Stem Cell Transplantation: Pediatric Pulmonary Arterial Hypertension and Pulmonary Veno-Occlusive Disease after Hematopoietic Stem Cell Transplantation Reviewed International journal
Kawashima, N; Fukasawa, Y; Nishikawa, E; Ohta-Ogo, K; Ishibashi-Ueda, H; Hamada, M; Ichikawa, D; Narita, A; Okuno, Y; Muramatsu, H; Nishio, N; Kojima, S; Kato, T; Takahashi, Y
TRANSPLANTATION AND CELLULAR THERAPY Vol. 27 ( 9 ) page： 786.e1 - 786.e8 2021.9
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Successful treatment of a novel type I interferonopathy due to a de novo PSMB9 gene mutation with a Janus kinase inhibitor Reviewed International journal
Kataoka, S; Kawashima, N; Okuno, Y; Muramatsu, H; Miwata, S; Narita, K; Hamada, M; Murakami, N; Taniguchi, R; Ichikawa, D; Kitazawa, H; Suzuki, K; Nishikawa, E; Narita, A; Nishio, N; Yamamoto, H; Fukasawa, Y; Kato, T; Yamamoto, H; Natsume, J; Kojima, S; Nishino, I; Taketani, T; Ohnishi, H; Takahashi, Y
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Vol. 148 ( 2 ) page： 639 - 644 2021.8
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Phosphorylated proteome analysis of a novel germline <i>ABL1</i> mutation causing an autosomal dominant syndrome with ventricular septal defect Reviewed International journal
Yamamoto, H; Hayano, S; Okuno, Y; Onoda, A; Kato, K; Nagai, N; Fukasawa, Y; Saitoh, S; Takahashi, Y; Kato, T
INTERNATIONAL JOURNAL OF CARDIOLOGY Vol. 326 page： 81 - 87 2021.3
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Prediction of postnatal clinical course in primary congenital dilated cardiomyopathy Reviewed International journal
Yamamoto, H; Fukasawa, Y; Ohashi, N; Yokoyama, T; Suzuki, K; Ota, T; Yasuda, K; Omoya, K; Takahashi, Y; Kato, T
PEDIATRICS INTERNATIONAL Vol. 61 ( 12 ) page： 1196 - 1201 2019.12
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Severe fetal cardiomegaly caused by multiple non-giant placental chorioangiomas Reviewed International journal
Yamamoto, H; Fukasawa, Y; Kato, T
CARDIOLOGY IN THE YOUNG Vol. 29 ( 12 ) page： 1559 - 1560 2019.12
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Frequent intragenic microdeletions of elastin in familial supravalvul araortic stenosis (vol 274, pg 290, 2019) Reviewed International journal
Hayano, S; Okuno, Y; Tsutsumi, M; Inagaki, H; Fukasawa, Y; Kurahashi, H; Kojima, S; Takahashi, Y; Kato, T
INTERNATIONAL JOURNAL OF CARDIOLOGY Vol. 292 page： 283 - 283 2019.10
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Ventricular tachycardia and chest pain due to foreign body in the pericardium caused by self-injurious behaviour Reviewed International journal
Yamamoto, H; Fukasawa, Y; Kato, T
CARDIOLOGY IN THE YOUNG Vol. 29 ( 9 ) page： 1217 - 1218 2019.9
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Frequent intragenic microdeletions of elastin in familial supravalvular aortic stenosis Reviewed International journal
Hayano Satoshi, Okuno Yusuke, Tsutsumi Makiko, Inagaki Hidehito, Fukasawa Yoshie, Kurahashi Hiroki, Kojima Seiji, Takahashi Yoshiyuki, Kato Taichi
INTERNATIONAL JOURNAL OF CARDIOLOGY Vol. 274 page： 290 - 295 2019.1
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Association of Severity of Coronary Artery Aneurysms in Patients With Kawasaki Disease and Risk of Later Coronary Events Reviewed International journal
Miura, M; Kobayashi, T; Kaneko, T; Ayusawa, M; Fukazawa, R; Fukushima, N; Fuse, S; Hamaoka, K; Hirono, K; Kato, T; Mitani, Y; Sato, S; Shimoyama, S; Shiono, J; Suda, K; Suzuki, H; Maeda, J; Waki, K; Kato, H; Saji, T; Yamagishi, H; Ozeki, A; Tomotsune, M; Yoshida, M; Akazawa, Y; Aso, K; Doi, S; Fukasawa, Y; Furuno, K; Hayabuchi, Y; Hayashi, M; Honda, T; Horita, N; Ikeda, K; Ishii, M; Iwashima, S; Kamada, M; Kaneko, M; Katyama, H; Kawamura, Y; Kitagawa, A; Komori, A; Kuraishi, K; Masuda, H; Matsuda, S; Matsuzaki, S; Mii, S; Miyamoto, T; Moritou, Y; Motoki, N; Nagumo, K; Nakamura, T; Nishihara, E; Nomura, Y; Ogata, S; Ohashi, H; Okumura, K; Omori, D; Sano, T; Suganuma, E; Takahashi, T; Takatsuki, S; Takeda, A; Terai, M; Toyono, M; Watanabe, K; Watanabe, M; Yamamoto, M; Yamamura, K; Doi, S; Fukasawa, Y; Katayama, H
JAMA PEDIATRICS Vol. 172 ( 5 ) page： e180030 2018.5
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Successful Infant Pneumonectomy with Unilateral Pulmonary Artery Occlusion Test Reviewed International journal
Kato Koji, Kato Taichi, Hayano Satoshi, Fukasawa Yoshie, Numaguchi Atsushi, Hattori Tetsuo, Saito Akiko, Sato Yoshiaki, Hayakawa Masahiro
INTERNATIONAL HEART JOURNAL Vol. 59 ( 1 ) page： 237 - 239 2018.1
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Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effect Reviewed
[Kishimoto Y], [Kato T],[Ito M],[Azuma Y],[Fukasawa Y], [Ohno K], [Kojima S]
J Thorac Cardiovasc Surg. Vol. 150 ( 3 ) page： 645-654.e3 2015.9
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門脈体循環シャントによる肺高血圧症及び肺内シャントを合併したNoonan症候群の１例 Reviewed
「永田佳敬」,「加藤太一」,「牧田智」,「池田麻衣子」,「深澤佳絵」,「岸本泰明」,「沼口敦」,「長井典子」
Vol. 31 ( 4 ) page： 212-219 2015.9
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Progressive aortic root and pulmonary artery aneurysms in a neonate with Loeys-Dietz syndrome type 1B. Reviewed
[Muramatsu Y],[Kosho T],[Magota M],[Yokotsuka T],[Nagata(Fukasawa) Y]
Am J Med Genet A Vol. 152A ( 2 ) page： 417-421 2010.2
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小児における大動脈内バルーンパンピング法の経験 Reviewed
「長井典子」,「永田（深澤)佳絵」,「河井悟」,「瀧本洋一」,「早川文雄」,「小倉良介」
日本小児科学会雑誌 Vol. 108 ( 4 ) page： 644-648 2004
Presentations 3
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MRIによる先天性横隔膜ヘルニアの遠隔期肺高血圧予測
深澤佳絵，早野聡，沼口敦，加藤太一他
第52回 日本小児循環器学会総会・学術総会
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先天性横隔膜ヘルニアの遠隔期肺高血圧～胎児肺容積は予後因子となりうるか～
「深澤 佳絵」, 「早野 聡」, 「沼口 敦」,「加藤 太一」他
第51回日本小児循環器学会総会・学術集会
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An explanation for the result of fetal echocardiography in our hospital International conference
The 48th Annual Meeting of Japanese Society of Pediatrics Cardiology and Cardiac Surgery
KAKENHI (Grants-in-Aid for Scientific Research) 2
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Grant number：19K08319 2019.4 - 2022.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
FUKASAWA YOSHIE
Authorship：Principal investigator Grant type：Competitive
Grant amount：\3380000 （ Direct Cost: \2600000 、 Indirect Cost：\780000 ）
We conducted search for causal genes in 8 families with familial WPW syndrome by whole-exome sequencing. Only one family identified a pathogenic variant of PRKAG2 gene, already known as the causal gene of familial WPW syndrome. A missense mutation in a causal gene(gene X) of hypertrophic cardiomyopathy was confirmed in one family with WPW syndrome for more than 3 generations. There was no report of WPW syndrome caused by this gene variant, it was considered to be a novel phenotype. The causal gene couldn't detect in the other 6 families.
We planned an experimental functional analysis to prove that the pathogenic variant of gene X presents with WPW syndrome. We planned to create a model mouse using CRISPER-Cas9 and detect supraventricullar tachycardia caused by WPW syndrome with an implantable electrocardiograph, but we couldn't realize due to equipment and financial problems. -
Development of novel therapy for chronic lung disease associated pulmonary arterial hypertension via proliferation of pulmonary alveoli.
Grant number：15K09687 2015.4 - 2018.3
KATO TAICHI
Authorship：Coinvestigator(s) Grant type：Competitive
In this study, we studied whether EGF promoted the proliferation of pulmonary alveoli and improved pulmonary hypertension using hyperoxia induced chronic lung disease rat neonate model. The time course study on the duration of hyperoxia revealed that compared to control rats, systolic right ventricular pressure (RVP) and the percentage of muscularized pulmonary vessels increased significantly in the rats after 14 days of hyperoxia challenge. Daily administration of EGF slightly decreased RVP and the percentage of muscularized pulmonary vessels and slightly improved the structure of pulmonary alveoli. Furthermore, hyperoxia decreased the expression of BMPR2, FGFR1 and MMP14 in the lung, which was not restored by EGF. These results showed chronic hyperoxia for 14 days caused chronic lung disease associated pulmonary hypertension in rat neonates. EGF administration showed only slight improvement of pulmonary hypertension and the structure of pulmonary alveoli in this model.