Phenotypes for general behavior, activity, and body temperature in 3q29 deletion model mice Open Access

Mori, D; Ikeda, R; Sawahata, M; Yamaguchi, S; Kodama, A; Hirao, T; Arioka, Y; Okumura, H; Inami, C; Suzuki, T; Hayashi, Y; Kato, H; Nawa, Y; Miyata, S; Kimura, H; Kushima, I; Aleksic, B; Mizoguchi, H; Nagai, T; Nakazawa, T; Hashimoto, R; Kaibuchi, K; Kume, K; Yamada, K; Ozaki, N

TRANSLATIONAL PSYCHIATRY   14 巻 ( 1 ) 頁： 138   2024年3月

Association between copy number variations in parkin (<i>PRKN</i>) and schizophrenia and autism spectrum disorder: A case-control study Open Access

Lo, TY; Kushima, I; Kimura, H; Aleksic, B; Okada, T; Kato, H; Inada, T; Nawa, Y; Torii, Y; Yamamoto, M; Kimura, R; Funabiki, Y; Kosaka, H; Numata, S; Kasai, K; Sasaki, T; Yokoyama, S; Munesue, T; Hashimoto, R; Yasuda, Y; Fujimoto, M; Usami, M; Itokawa, M; Arai, M; Ohi, K; Someya, T; Watanabe, Y; Egawa, J; Takahashi, T; Suzuki, M; Yamasue, H; Iwata, N; Ikeda, M; Ozaki, N

NEUROPSYCHOPHARMACOLOGY REPORTS   44 巻 ( 1 ) 頁： 42 - 50   2024年3月

Machine learning algorithm-based estimation model for the severity of depression assessed using Montgomery-Asberg depression rating scale Open Access

Shimamoto, M; Ishizuka, K; Ohtani, K; Inada, T; Yamamoto, M; Tachibana, M; Kimura, H; Sakai, Y; Kobayashi, K; Ozaki, N; Ikeda, M

NEUROPSYCHOPHARMACOLOGY REPORTS   44 巻 ( 1 ) 頁： 115 - 120   2024年3月

Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction Open Access

Ishikawa, M; Yamamoto, Y; Wulaer, B; Kunisawa, K; Fujigaki, H; Ando, T; Kimura, H; Kushima, I; Arioka, Y; Torii, Y; Mouri, A; Ozaki, N; Nabeshima, T; Saito, K

FEBS JOURNAL   291 巻 ( 5 ) 頁： 945 - 964   2024年3月

Clinical characterization of patients with schizophrenia and 16p13.11 duplication: A case series Open Access

Kimura, H; Kushima, I; Banno, M; Inada, T; Yoshimi, A; Aleksic, B; Ozaki, N

NEUROPSYCHOPHARMACOLOGY REPORTS   43 巻 ( 2 ) 頁： 267 - 271   2023年6月

The genetic architecture of schizophrenia: review of large-scale genetic studies

Kato, H; Kimura, H; Kushima, I; Takahashi, N; Aleksic, B; Ozaki, N

JOURNAL OF HUMAN GENETICS   68 巻 ( 3 ) 頁： 175 - 182   2023年3月

Electroconvulsive therapy as a potential therapeutic option in psychiatric-onset prodromal dementia with Lewy bodies

Kimura, H; Yokoyama, H; Torii, Y; Fujishiro, H

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY   38 巻 ( 1 ) 頁： e5863   2023年1月

X chromosome aneuploidies and schizophrenia: association analysis and phenotypic characterization Open Access

Kushima, I; Aleksic, B; Kimura, H; Nakatochi, M; Lo, T; Ikeda, M; Arai, M; Hashimoto, R; Numata, S; Okamura, Y; Obara, T; Inada, T; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   76 巻 ( 12 ) 頁： 667 - 673   2022年12月

Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder Open Access

Kushima, I; Nakatochi, M; Aleksic, B; Okada, T; Kimura, H; Kato, H; Morikawa, M; Inada, T; Ishizuka, K; Torii, Y; Nakamura, Y; Tanaka, S; Imaeda, M; Takahashi, N; Yamamoto, M; Iwamoto, K; Nawa, Y; Ogawa, N; Iritani, S; Hayashi, Y; Lo, TY; Otgonbayar, G; Furuta, S; Iwata, N; Ikeda, M; Saito, T; Ninomiya, K; Okochi, T; Hashimoto, R; Yamamori, H; Yasuda, Y; Fujimoto, M; Miura, K; Itokawa, M; Arai, M; Miyashita, M; Toriumi, K; Ohi, K; Shioiri, T; Kitaichi, K; Someya, T; Watanabe, Y; Egawa, J; Takahashi, T; Suzuki, M; Sasaki, T; Tochigi, M; Nishimura, F; Yamasue, H; Kuwabara, H; Wakuda, T; Kato, TA; Kanba, S; Horikawa, H; Usami, M; Kodaira, M; Watanabe, K; Yoshikawa, T; Toyota, T; Yokoyama, S; Munesue, T; Kimura, R; Funabiki, Y; Kosaka, H; Jung, MY; Kasai, K; Ikegame, T; Jinde, S; Numata, S; Kinoshita, M; Kato, T; Kakiuchi, C; Yamakawa, K; Suzuki, T; Hashimoto, N; Ishikawa, S; Yamagata, B; Nio, S; Murai, T; Son, S; Kunii, Y; Yabe, H; Inagaki, M; Goto, Y; Okumura, Y; Ito, T; Arioka, Y; Mori, D; Ozaki, N

BIOLOGICAL PSYCHIATRY   92 巻 ( 5 ) 頁： 362 - 374   2022年9月

Exome sequencing analysis of Japanese autism spectrum disorder case-control sample supports an increased burden of synaptic function-related genes Open Access

Kimura, H; Nakatochi, M; Aleksic, B; Guevara, J; Toyama, M; Hayashi, Y; Kato, H; Kushima, I; Morikawa, M; Ishizuka, K; Okada, T; Tsurusaki, Y; Fujita, A; Miyake, N; Ogi, T; Takata, A; Matsumoto, N; Buxbaum, J; Ozaki, N; Sebat, J

TRANSLATIONAL PSYCHIATRY   12 巻 ( 1 ) 頁： 265   2022年7月

Investigation of<i> OLIG2</i> as a candidate gene for schizophrenia and autism spectrum disorder Open Access

Furuta, S; Aleksic, B; Nawa, Y; Kimura, H; Kushima, I; Ishizuka, K; Kato, H; Toyama, M; Arioka, Y; Mori, D; Morikawa, M; Inada, T; Ozaki, N

NAGOYA JOURNAL OF MEDICAL SCIENCE   84 巻 ( 2 ) 頁： 260 - 268   2022年5月

Severe and long-lasting neuropsychiatric symptoms after mild respiratory symptoms caused by COVID-19: A case report.

Jozuka R, Kimura H, Uematsu T, Fujigaki H, Yamamoto Y, Kobayashi M, Kawabata K, Koike H, Inada T, Saito K, Katsuno M, Ozaki N

Neuropsychopharmacology reports   42 巻 ( 1 ) 頁： 114 - 119   2022年3月

Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder Open Access

Wang, CY; Horigane, S; Wakamori, M; Ueda, S; Kawabata, T; Fujii, H; Kushima, I; Kimura, H; Ishizuka, K; Nakamura, Y; Iwayama, Y; Ikeda, M; Iwata, N; Okada, T; Aleksic, B; Mori, D; Yoshida, T; Bito, H; Yoshikawa, T; Takemoto-Kimura, S; Ozaki, N

TRANSLATIONAL PSYCHIATRY   12 巻 ( 1 ) 頁： 84   2022年2月

Sequencing of selected chromatin remodelling genes reveals increased burden of rare missense variants in ASD patients from the Japanese population

Lo, T; Kushima, I; Aleksic, B; Kato, H; Nawa, Y; Hayashi, Y; Otgonbayar, G; Kimura, H; Arioka, Y; Mori, D; Ozaki, N

INTERNATIONAL REVIEW OF PSYCHIATRY   34 巻 ( 2 ) 頁： 154 - 167   2022年2月

Autism spectrum disorder comorbid with obsessive compulsive disorder and eating disorder in a woman with <i>NBEA</i> deletion Open Access

Kato, H; Kushima, I; Yoshimi, A; Ishizuka, K; Kimura, H; Aleksic, B; Takahashi, N; Okada, T; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   76 巻 ( 1 ) 頁： 36 - 38   2022年1月

Exome sequencing of Japanese schizophrenia multiplex families supports the involvement of calcium ion channels Open Access

Toyama, M; Takasaki, Y; Branko, A; Kimura, H; Kato, H; Nawa, Y; Kushima, I; Ishizuka, K; Shimamura, T; Ogi, T; Ozaki, N

PLOS ONE   17 巻 ( 5 ) 頁： e0268321   2022年

Elucidation of molecular pathogenesis and drug development for psychiatric disorders from rare disease-susceptibility variants Open Access

Kimura, H; Mori, D; Aleksic, B; Ozaki, N

NEUROSCIENCE RESEARCH   170 巻   頁： 24 - 31   2021年9月

Rare genetic variants in the gene encoding histone lysine demethylase 4C (KDM4C) and their contributions to susceptibility to schizophrenia and autism spectrum disorder

Kato Hidekazu, Kushima Itaru, Mori Daisuke, Yoshimi Akira, Aleksic Branko, Nawa Yoshihiro, Toyama Miho, Furuta Sho, Yu Yanjie, Ishizuka Kanako, Kimura Hiroki, Arioka Yuko, Tsujimura Keita, Morikawa Mako, Okada Takashi, Inada Toshiya, Nakatochi Masahiro, Shinjo Keiko, Kondo Yutaka, Kaibuchi Kozo, Funabiki Yasuko, Kimura Ryo, Suzuki Toshimitsu, Yamakawa Kazuhiro, Ikeda Masashi, Iwata Nakao, Takahashi Tsutomu, Suzuki Michio, Okahisa Yuko, Takaki Manabu, Egawa Jun, Someya Toshiyuki, Ozaki Norio

TRANSLATIONAL PSYCHIATRY   10 巻 ( 1 ) 頁： 421   2020年12月

Rare single-nucleotide DAB1 variants and their contribution to Schizophrenia and autism spectrum disorder susceptibility

Nawa Yoshihiro, Kimura Hiroki, Mori Daisuke, Kato Hidekazu, Toyama Miho, Furuta Sho, Yu Yanjie, Ishizuka Kanako, Kushima Itaru, Aleksic Branko, Arioka Yuko, Morikawa Mako, Okada Takashi, Inada Toshiya, Kaibuchi Kozo, Ikeda Masashi, Iwata Nakao, Suzuki Michio, Okahisa Yuko, Egawa Jun, Someya Toshiyuki, Nishimura Fumichika, Sasaki Tsukasa, Ozaki Norio

HUMAN GENOME VARIATION   7 巻 ( 1 ) 頁： 37   2020年11月

Functional characterization of rare <i>NRXN1</i> variants identified in autism spectrum disorders and schizophrenia Open Access

Ishizuka, K; Yoshida, T; Kawabata, T; Imai, A; Mori, H; Kimura, H; Inada, T; Okahisa, Y; Egawa, J; Usami, M; Kushima, I; Morikawa, M; Okada, T; Ikeda, M; Branko, A; Mori, D; Someya, T; Iwata, N; Ozaki, N

JOURNAL OF NEURODEVELOPMENTAL DISORDERS   12 巻 ( 1 ) 頁： 25   2020年9月

<i>ARHGAP10</i>, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk Open Access

Sekiguchi, M; Sobue, A; Kushima, I; Wang, CY; Arioka, Y; Kato, H; Kodama, A; Kubo, H; Ito, N; Sawahata, M; Hada, K; Ikeda, R; Shinno, M; Mizukoshi, C; Tsujimura, K; Yoshimi, A; Ishizuka, K; Takasaki, Y; Kimura, H; Xing, JR; Yu, YJ; Yamamoto, M; Okada, T; Shishido, E; Inada, T; Nakatochi, M; Takano, T; Kuroda, K; Amano, M; Aleksic, B; Yamomoto, T; Sakuma, T; Aida, T; Tanaka, K; Hashimoto, R; Arai, M; Ikeda, M; Iwata, N; Shimamura, T; Nagai, T; Nabeshima, T; Kaibuchi, K; Yamada, K; Mori, D; Ozaki, N

TRANSLATIONAL PSYCHIATRY   10 巻 ( 1 ) 頁： 247   2020年7月

Generation and analysis of novel Reln-deleted mouse model corresponding to exonic Reln deletion in schizophrenia

Sawahata Masahito, Mori Daisuke, Arioka Yuko, Kubo Hisako, Kushima Itaru, Kitagawa Kanako, Sobue Akira, Shishido Emiko, Sekiguchi Mariko, Kodama Akiko, Ikeda Ryosuke, Aleksic Branko, Kimura Hiroki, Ishizuka Kanako, Nagai Taku, Kaibuchi Kozo, Nabeshima Toshitaka, Yamada Kiyofumi, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES   74 巻 ( 5 ) 頁： 318 - 327   2020年5月

INVESTIGATION OF RARE SINGLE-NUCLEOTIDE DAB1 VARIANTS AND ITS CONTRIBUTION TO SCHIZOPHRENIA AND AUTISM SPECTRUM DISORDER SUSCEPTIBILITY

Nawa, Y; Kimura, H; Ishizuka, K; Kushima, I; Aleksic, B; Ozaki, N

EUROPEAN NEUROPSYCHOPHARMACOLOGY   29 巻   頁： S164 - S165   2019年10月

Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients (vol 9, 126, 2019) Open Access

Yoshimi, A; Yamada, S; Kunimoto, S; Aleksic, B; Hirakawa, A; Ohashi, M; Matsumoto, Y; Hada, K; Itoh, N; Arioka, Y; Kimura, H; Kushima, I; Nakamura, Y; Shiino, T; Mori, D; Tanaka, S; Hamada, S; Noda, Y; Nagai, T; Yamada, K; Ozaki, N

TRANSLATIONAL PSYCHIATRY   9 巻 ( 1 ) 頁： 146   2019年5月

Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients Open Access

Yoshimi, A; Yamada, S; Kunimoto, S; Aleksic, B; Hirakawa, A; Ohashi, M; Matsumoto, Y; Hada, K; Itoh, N; Arioka, Y; Kimura, H; Kushima, I; Nakamura, Y; Shiino, T; Mori, D; Tanaka, S; Hamada, S; Noda, Y; Nagai, T; Yamada, K; Ozaki, N

TRANSLATIONAL PSYCHIATRY   9 巻 ( 1 ) 頁： 126   2019年4月

A NOVEL RARE VARIANT R292H IN RTN4R AFFECTS GROWTH CONE FORMATION AND POSSIBLY CONTRIBUTES TO SCHIZOPHRENIA SUSCEPTIBILITY

Kimura, H; Ishizuka, K; Wang, CY; Kushima, I; Morikawa, M; Uno, Y; Okada, T; Inanda, T; Aleksic, B; Mori, D; Ozaki, N

EUROPEAN NEUROPSYCHOPHARMACOLOGY   29 巻   頁： S1014 - S1014   2019年

TARGET SEQUENCING OF GENES INVOLVED IN NEURODEVELOPMENT FROM WHOLE GENOME COPY NUMBER VARIATION ANALYSIS OF JAPANESE SCHIZOPHRENIA

Kimura Hiroki, Aleksic Branko, Ishizuka Kanako, Wang Chenyao, Kushima Itaru, Ozaki Norio

EUROPEAN NEUROPSYCHOPHARMACOLOGY   29 巻   頁： 1334 - 1334   2019年

Assessment of a glyoxalase I frameshift variant, p.P122fs, in Japanese patients with schizophrenia

Ishizuka, K; Kimura, H; Kushima, I; Inada, T; Okahisa, Y; Ikeda, M; Iwata, N; Mori, D; Aleksic, B; Ozaki, N

PSYCHIATRIC GENETICS   28 巻 ( 5 ) 頁： 90 - 93   2018年10月

Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights Open Access

Kushima, I; Aleksic, B; Nakatochi, M; Shimamura, T; Okada, T; Uno, Y; Morikawa, M; Ishizuka, K; Shiino, T; Kimura, H; Arioka, Y; Yoshimi, A; Takasaki, Y; Yu, Y; Nakamura, Y; Yamamoto, M; Iidaka, T; Iritani, S; Inada, T; Ogawa, N; Shishido, E; Torii, Y; Kawano, N; Omura, Y; Yoshikawa, T; Uchiyama, T; Yamamoto, T; Ikeda, M; Hashimoto, R; Yamamori, H; Yasuda, Y; Someya, T; Watanabe, Y; Egawa, J; Nunokawa, A; Itokawa, M; Arai, M; Miyashita, M; Kobori, A; Suzuki, M; Takahashi, T; Usami, M; Kodaira, M; Watanabe, K; Sasaki, T; Kuwabara, H; Tochigi, M; Nishimura, F; Yamasue, H; Eriguchi, Y; Benner, S; Kojima, M; Yassin, W; Munesue, T; Yokoyama, S; Kimura, R; Funabiki, Y; Kosaka, H; Ishitobi, M; Ohmori, T; Numata, S; Yoshikawa, T; Toyota, T; Yamakawa, K; Suzuki, T; Inoue, Y; Nakaoka, K; Goto, YI; Inagaki, M; Hashimoto, N; Kusumi, I; Son, S; Murai, T; Ikegame, T; Okada, N; Kasai, K; Kunimoto, S; Mori, D; Iwata, N; Ozaki, N

CELL REPORTS   24 巻 ( 11 ) 頁： 2838 - 2856   2018年9月

Single-cell trajectory analysis of human homogenous neurons carrying a rare RELN variant

Arioka Yuko, Shishido Emiko, Kubo Hisako, Kushima Itaru, Yoshimi Akira, Kimura Hiroki, Ishizuka Kanako, Aleksic Branko, Maeda Takuji, Ishikawa Mitsuru, Kuzumaki Naoko, Okano Hideyuki, Mori Daisuke, Ozaki Norio

TRANSLATIONAL PSYCHIATRY   8 巻 ( 1 ) 頁： 129   2018年7月

Copy Number Variant in the Region of Adenosine Kinase (ADK) and Its Possible Contribution to Schizophrenia Susceptibility Open Access

Kimura, H; Kushima, I; Yohimi, A; Aleksic, B; Ozaki, N

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   21 巻 ( 5 ) 頁： 405 - 409   2018年5月

Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility

Yu Yanjie, Lin Yingni, Takasaki Yuto, Wang Chenyao, Kimura Hiroki, Xing Jingrui, Ishizuka Kanako, Toyama Miho, Kushima Itaru, Mori Daisuke, Arioka Yuko, Uno Yota, Shiino Tomoko, Nakamura Yukako, Okada Takashi, Morikawa Mako, Ikeda Masashi, Iwata Nakao, Okahisa Yuko, Takaki Manabu, Sakamoto Shinji, Someya Toshiyuki, Egawa Jun, Usami Masahide, Kodaira Masaki, Yoshimi Akira, Oya-Ito Tomoko, Aleksic Branko, Ohno Kinji, Ozaki Norio

TRANSLATIONAL PSYCHIATRY   8 巻 ( 1 ) 頁： 12   2018年1月

IDENTIFICATION OF RARE DISRUPTIVE VARIANTS IN VOLTAGE-GATED CHANNEL GENES (CACNA1C, CACNA1D, CACNA1S, CACNA1I) IN JAPANESE SAMPLES OF SCHIZOPHRENIA AND AUTISM SPECTRUM DISORDER USING ION TORRENT PGM PLATFORM

Wang, C; Kimura, H; Xing, J; Ishizuka, K; Kushima, I; Arioka, Y; Yoshimi, A; Nakamura, Y; Shiino, Y; Oya, Y; Takasaki, Y; Aleksic, B; Mori, D; Ozaki, N

EUROPEAN NEUROPSYCHOPHARMACOLOGY   27 巻   頁： S341 - S342   2017年10月

MUTATION SCREENING OF THE PCDH15 GENE IN PATIENTS SUFFERING FROM AUTISM SPECTRUM DISORDERS AND SCHIZOPHRENIA

Ishizuka, K; Wang, CY; Kimura, H; Xing, JR; Kushima, I; Arioka, Y; Yoshimi, A; Nakamura, Y; Oya-Ito, T; Takasaki, Y; Uno, Y; Okada, T; Mori, D; Aleksic, B; Ozaki, N

EUROPEAN NEUROPSYCHOPHARMACOLOGY   27 巻   頁： S162 - S163   2017年10月

A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility Open Access

Kimura, H; Fujita, Y; Kawabata, T; Ishizuka, K; Wang, C; Iwayama, Y; Okahisa, Y; Kushima, I; Morikawa, M; Uno, Y; Okada, T; Ikeda, M; Inada, T; Branko, A; Mori, D; Yoshikawa, T; Iwata, N; Nakamura, H; Yamashita, T; Ozaki, N

TRANSLATIONAL PSYCHIATRY   7 巻 ( 8 ) 頁： e1214   2017年8月

Rare genetic variants in <i>CX3CR1</i> and their contribution to the increased risk of schizophrenia and autism spectrum disorders Open Access

Ishizuka, K; Fujita, Y; Kawabata, T; Kimura, H; Iwayama, Y; Inada, T; Okahisa, Y; Egawa, J; Usami, M; Kushima, I; Uno, Y; Okada, T; Ikeda, M; Aleksic, B; Mori, D; Someya, T; Yoshikawa, T; Iwata, N; Nakamura, H; Yamashita, T; Ozaki, N

TRANSLATIONAL PSYCHIATRY   7 巻 ( 8 ) 頁： e1184   2017年8月

High-resolution copy number variation analysis of schizophrenia in Japan

Kushima, I; Aleksic, B; Nakatochi, M; Shimamura, T; Shiino, T; Yoshimi, A; Kimura, H; Takasaki, Y; Wang, C; Xing, J; Ishizuka, K; Oya-Ito, T; Nakamura, Y; Arioka, Y; Maeda, T; Yamamoto, M; Yoshida, M; Noma, H; Hamada, S; Morikawa, M; Uno, Y; Okada, T; Iidaka, T; Iritani, S; Yamamoto, T; Miyashita, M; Kobori, A; Arai, M; Itokawa, M; Cheng, MC; Chuang, YA; Chen, CH; Suzuki, M; Takahashi, T; Hashimoto, R; Yamamori, H; Yasuda, Y; Watanabe, Y; Nunokawa, A; Someya, T; Ikeda, M; Toyota, T; Yoshikawa, T; Numata, S; Ohmori, T; Kunimoto, S; Mori, D; Iwata, N; Ozaki, N

MOLECULAR PSYCHIATRY   22 巻 ( 3 ) 頁： 430 - 440   2017年3月