Phenotypes for general behavior, activity, and body temperature in 3q29 deletion model mice Open Access

Mori, D; Ikeda, R; Sawahata, M; Yamaguchi, S; Kodama, A; Hirao, T; Arioka, Y; Okumura, H; Inami, C; Suzuki, T; Hayashi, Y; Kato, H; Nawa, Y; Miyata, S; Kimura, H; Kushima, I; Aleksic, B; Mizoguchi, H; Nagai, T; Nakazawa, T; Hashimoto, R; Kaibuchi, K; Kume, K; Yamada, K; Ozaki, N

TRANSLATIONAL PSYCHIATRY   Vol. 14 ( 1 ) page： 138   2024.3

Association between copy number variations in parkin (<i>PRKN</i>) and schizophrenia and autism spectrum disorder: A case-control study Open Access

Lo, TY; Kushima, I; Kimura, H; Aleksic, B; Okada, T; Kato, H; Inada, T; Nawa, Y; Torii, Y; Yamamoto, M; Kimura, R; Funabiki, Y; Kosaka, H; Numata, S; Kasai, K; Sasaki, T; Yokoyama, S; Munesue, T; Hashimoto, R; Yasuda, Y; Fujimoto, M; Usami, M; Itokawa, M; Arai, M; Ohi, K; Someya, T; Watanabe, Y; Egawa, J; Takahashi, T; Suzuki, M; Yamasue, H; Iwata, N; Ikeda, M; Ozaki, N

NEUROPSYCHOPHARMACOLOGY REPORTS   Vol. 44 ( 1 ) page： 42 - 50   2024.3

Machine learning algorithm-based estimation model for the severity of depression assessed using Montgomery-Asberg depression rating scale Open Access

Shimamoto, M; Ishizuka, K; Ohtani, K; Inada, T; Yamamoto, M; Tachibana, M; Kimura, H; Sakai, Y; Kobayashi, K; Ozaki, N; Ikeda, M

NEUROPSYCHOPHARMACOLOGY REPORTS   Vol. 44 ( 1 ) page： 115 - 120   2024.3

Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction Open Access

Ishikawa, M; Yamamoto, Y; Wulaer, B; Kunisawa, K; Fujigaki, H; Ando, T; Kimura, H; Kushima, I; Arioka, Y; Torii, Y; Mouri, A; Ozaki, N; Nabeshima, T; Saito, K

FEBS JOURNAL   Vol. 291 ( 5 ) page： 945 - 964   2024.3

Clinical characterization of patients with schizophrenia and 16p13.11 duplication: A case series Open Access

Kimura, H; Kushima, I; Banno, M; Inada, T; Yoshimi, A; Aleksic, B; Ozaki, N

NEUROPSYCHOPHARMACOLOGY REPORTS   Vol. 43 ( 2 ) page： 267 - 271   2023.6

The genetic architecture of schizophrenia: review of large-scale genetic studies

Kato, H; Kimura, H; Kushima, I; Takahashi, N; Aleksic, B; Ozaki, N

JOURNAL OF HUMAN GENETICS   Vol. 68 ( 3 ) page： 175 - 182   2023.3

Electroconvulsive therapy as a potential therapeutic option in psychiatric-onset prodromal dementia with Lewy bodies

Kimura, H; Yokoyama, H; Torii, Y; Fujishiro, H

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY   Vol. 38 ( 1 ) page： e5863   2023.1

X chromosome aneuploidies and schizophrenia: association analysis and phenotypic characterization Open Access

Kushima, I; Aleksic, B; Kimura, H; Nakatochi, M; Lo, T; Ikeda, M; Arai, M; Hashimoto, R; Numata, S; Okamura, Y; Obara, T; Inada, T; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 76 ( 12 ) page： 667 - 673   2022.12

Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder Open Access

Kushima, I; Nakatochi, M; Aleksic, B; Okada, T; Kimura, H; Kato, H; Morikawa, M; Inada, T; Ishizuka, K; Torii, Y; Nakamura, Y; Tanaka, S; Imaeda, M; Takahashi, N; Yamamoto, M; Iwamoto, K; Nawa, Y; Ogawa, N; Iritani, S; Hayashi, Y; Lo, TY; Otgonbayar, G; Furuta, S; Iwata, N; Ikeda, M; Saito, T; Ninomiya, K; Okochi, T; Hashimoto, R; Yamamori, H; Yasuda, Y; Fujimoto, M; Miura, K; Itokawa, M; Arai, M; Miyashita, M; Toriumi, K; Ohi, K; Shioiri, T; Kitaichi, K; Someya, T; Watanabe, Y; Egawa, J; Takahashi, T; Suzuki, M; Sasaki, T; Tochigi, M; Nishimura, F; Yamasue, H; Kuwabara, H; Wakuda, T; Kato, TA; Kanba, S; Horikawa, H; Usami, M; Kodaira, M; Watanabe, K; Yoshikawa, T; Toyota, T; Yokoyama, S; Munesue, T; Kimura, R; Funabiki, Y; Kosaka, H; Jung, MY; Kasai, K; Ikegame, T; Jinde, S; Numata, S; Kinoshita, M; Kato, T; Kakiuchi, C; Yamakawa, K; Suzuki, T; Hashimoto, N; Ishikawa, S; Yamagata, B; Nio, S; Murai, T; Son, S; Kunii, Y; Yabe, H; Inagaki, M; Goto, Y; Okumura, Y; Ito, T; Arioka, Y; Mori, D; Ozaki, N

BIOLOGICAL PSYCHIATRY   Vol. 92 ( 5 ) page： 362 - 374   2022.9

Exome sequencing analysis of Japanese autism spectrum disorder case-control sample supports an increased burden of synaptic function-related genes Open Access

Kimura, H; Nakatochi, M; Aleksic, B; Guevara, J; Toyama, M; Hayashi, Y; Kato, H; Kushima, I; Morikawa, M; Ishizuka, K; Okada, T; Tsurusaki, Y; Fujita, A; Miyake, N; Ogi, T; Takata, A; Matsumoto, N; Buxbaum, J; Ozaki, N; Sebat, J

TRANSLATIONAL PSYCHIATRY   Vol. 12 ( 1 ) page： 265   2022.7

Investigation of<i> OLIG2</i> as a candidate gene for schizophrenia and autism spectrum disorder Open Access

Furuta, S; Aleksic, B; Nawa, Y; Kimura, H; Kushima, I; Ishizuka, K; Kato, H; Toyama, M; Arioka, Y; Mori, D; Morikawa, M; Inada, T; Ozaki, N

NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 2 ) page： 260 - 268   2022.5

Severe and long-lasting neuropsychiatric symptoms after mild respiratory symptoms caused by COVID-19: A case report.

Jozuka R, Kimura H, Uematsu T, Fujigaki H, Yamamoto Y, Kobayashi M, Kawabata K, Koike H, Inada T, Saito K, Katsuno M, Ozaki N

Neuropsychopharmacology reports   Vol. 42 ( 1 ) page： 114 - 119   2022.3

Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder Open Access

Wang, CY; Horigane, S; Wakamori, M; Ueda, S; Kawabata, T; Fujii, H; Kushima, I; Kimura, H; Ishizuka, K; Nakamura, Y; Iwayama, Y; Ikeda, M; Iwata, N; Okada, T; Aleksic, B; Mori, D; Yoshida, T; Bito, H; Yoshikawa, T; Takemoto-Kimura, S; Ozaki, N

TRANSLATIONAL PSYCHIATRY   Vol. 12 ( 1 ) page： 84   2022.2

Sequencing of selected chromatin remodelling genes reveals increased burden of rare missense variants in ASD patients from the Japanese population

Lo, T; Kushima, I; Aleksic, B; Kato, H; Nawa, Y; Hayashi, Y; Otgonbayar, G; Kimura, H; Arioka, Y; Mori, D; Ozaki, N

INTERNATIONAL REVIEW OF PSYCHIATRY   Vol. 34 ( 2 ) page： 154 - 167   2022.2

Autism spectrum disorder comorbid with obsessive compulsive disorder and eating disorder in a woman with <i>NBEA</i> deletion Open Access

Kato, H; Kushima, I; Yoshimi, A; Ishizuka, K; Kimura, H; Aleksic, B; Takahashi, N; Okada, T; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 76 ( 1 ) page： 36 - 38   2022.1

Exome sequencing of Japanese schizophrenia multiplex families supports the involvement of calcium ion channels Open Access

Toyama, M; Takasaki, Y; Branko, A; Kimura, H; Kato, H; Nawa, Y; Kushima, I; Ishizuka, K; Shimamura, T; Ogi, T; Ozaki, N

PLOS ONE   Vol. 17 ( 5 ) page： e0268321   2022

Elucidation of molecular pathogenesis and drug development for psychiatric disorders from rare disease-susceptibility variants Open Access

Kimura, H; Mori, D; Aleksic, B; Ozaki, N

NEUROSCIENCE RESEARCH   Vol. 170   page： 24 - 31   2021.9

Rare genetic variants in the gene encoding histone lysine demethylase 4C (KDM4C) and their contributions to susceptibility to schizophrenia and autism spectrum disorder

Kato Hidekazu, Kushima Itaru, Mori Daisuke, Yoshimi Akira, Aleksic Branko, Nawa Yoshihiro, Toyama Miho, Furuta Sho, Yu Yanjie, Ishizuka Kanako, Kimura Hiroki, Arioka Yuko, Tsujimura Keita, Morikawa Mako, Okada Takashi, Inada Toshiya, Nakatochi Masahiro, Shinjo Keiko, Kondo Yutaka, Kaibuchi Kozo, Funabiki Yasuko, Kimura Ryo, Suzuki Toshimitsu, Yamakawa Kazuhiro, Ikeda Masashi, Iwata Nakao, Takahashi Tsutomu, Suzuki Michio, Okahisa Yuko, Takaki Manabu, Egawa Jun, Someya Toshiyuki, Ozaki Norio

TRANSLATIONAL PSYCHIATRY   Vol. 10 ( 1 ) page： 421   2020.12

Rare single-nucleotide DAB1 variants and their contribution to Schizophrenia and autism spectrum disorder susceptibility

Nawa Yoshihiro, Kimura Hiroki, Mori Daisuke, Kato Hidekazu, Toyama Miho, Furuta Sho, Yu Yanjie, Ishizuka Kanako, Kushima Itaru, Aleksic Branko, Arioka Yuko, Morikawa Mako, Okada Takashi, Inada Toshiya, Kaibuchi Kozo, Ikeda Masashi, Iwata Nakao, Suzuki Michio, Okahisa Yuko, Egawa Jun, Someya Toshiyuki, Nishimura Fumichika, Sasaki Tsukasa, Ozaki Norio

HUMAN GENOME VARIATION   Vol. 7 ( 1 ) page： 37   2020.11

Functional characterization of rare <i>NRXN1</i> variants identified in autism spectrum disorders and schizophrenia Open Access

Ishizuka, K; Yoshida, T; Kawabata, T; Imai, A; Mori, H; Kimura, H; Inada, T; Okahisa, Y; Egawa, J; Usami, M; Kushima, I; Morikawa, M; Okada, T; Ikeda, M; Branko, A; Mori, D; Someya, T; Iwata, N; Ozaki, N

JOURNAL OF NEURODEVELOPMENTAL DISORDERS   Vol. 12 ( 1 ) page： 25   2020.9

<i>ARHGAP10</i>, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk Open Access

Sekiguchi, M; Sobue, A; Kushima, I; Wang, CY; Arioka, Y; Kato, H; Kodama, A; Kubo, H; Ito, N; Sawahata, M; Hada, K; Ikeda, R; Shinno, M; Mizukoshi, C; Tsujimura, K; Yoshimi, A; Ishizuka, K; Takasaki, Y; Kimura, H; Xing, JR; Yu, YJ; Yamamoto, M; Okada, T; Shishido, E; Inada, T; Nakatochi, M; Takano, T; Kuroda, K; Amano, M; Aleksic, B; Yamomoto, T; Sakuma, T; Aida, T; Tanaka, K; Hashimoto, R; Arai, M; Ikeda, M; Iwata, N; Shimamura, T; Nagai, T; Nabeshima, T; Kaibuchi, K; Yamada, K; Mori, D; Ozaki, N

TRANSLATIONAL PSYCHIATRY   Vol. 10 ( 1 ) page： 247   2020.7

Generation and analysis of novel Reln-deleted mouse model corresponding to exonic Reln deletion in schizophrenia

Sawahata Masahito, Mori Daisuke, Arioka Yuko, Kubo Hisako, Kushima Itaru, Kitagawa Kanako, Sobue Akira, Shishido Emiko, Sekiguchi Mariko, Kodama Akiko, Ikeda Ryosuke, Aleksic Branko, Kimura Hiroki, Ishizuka Kanako, Nagai Taku, Kaibuchi Kozo, Nabeshima Toshitaka, Yamada Kiyofumi, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES   Vol. 74 ( 5 ) page： 318 - 327   2020.5

INVESTIGATION OF RARE SINGLE-NUCLEOTIDE DAB1 VARIANTS AND ITS CONTRIBUTION TO SCHIZOPHRENIA AND AUTISM SPECTRUM DISORDER SUSCEPTIBILITY

Nawa, Y; Kimura, H; Ishizuka, K; Kushima, I; Aleksic, B; Ozaki, N

EUROPEAN NEUROPSYCHOPHARMACOLOGY   Vol. 29   page： S164 - S165   2019.10

Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients (vol 9, 126, 2019) Open Access

Yoshimi, A; Yamada, S; Kunimoto, S; Aleksic, B; Hirakawa, A; Ohashi, M; Matsumoto, Y; Hada, K; Itoh, N; Arioka, Y; Kimura, H; Kushima, I; Nakamura, Y; Shiino, T; Mori, D; Tanaka, S; Hamada, S; Noda, Y; Nagai, T; Yamada, K; Ozaki, N

TRANSLATIONAL PSYCHIATRY   Vol. 9 ( 1 ) page： 146   2019.5

Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients Open Access

Yoshimi, A; Yamada, S; Kunimoto, S; Aleksic, B; Hirakawa, A; Ohashi, M; Matsumoto, Y; Hada, K; Itoh, N; Arioka, Y; Kimura, H; Kushima, I; Nakamura, Y; Shiino, T; Mori, D; Tanaka, S; Hamada, S; Noda, Y; Nagai, T; Yamada, K; Ozaki, N

TRANSLATIONAL PSYCHIATRY   Vol. 9 ( 1 ) page： 126   2019.4

A NOVEL RARE VARIANT R292H IN RTN4R AFFECTS GROWTH CONE FORMATION AND POSSIBLY CONTRIBUTES TO SCHIZOPHRENIA SUSCEPTIBILITY

Kimura, H; Ishizuka, K; Wang, CY; Kushima, I; Morikawa, M; Uno, Y; Okada, T; Inanda, T; Aleksic, B; Mori, D; Ozaki, N

EUROPEAN NEUROPSYCHOPHARMACOLOGY   Vol. 29   page： S1014 - S1014   2019

TARGET SEQUENCING OF GENES INVOLVED IN NEURODEVELOPMENT FROM WHOLE GENOME COPY NUMBER VARIATION ANALYSIS OF JAPANESE SCHIZOPHRENIA

Kimura Hiroki, Aleksic Branko, Ishizuka Kanako, Wang Chenyao, Kushima Itaru, Ozaki Norio

EUROPEAN NEUROPSYCHOPHARMACOLOGY   Vol. 29   page： 1334 - 1334   2019

Assessment of a glyoxalase I frameshift variant, p.P122fs, in Japanese patients with schizophrenia

Ishizuka, K; Kimura, H; Kushima, I; Inada, T; Okahisa, Y; Ikeda, M; Iwata, N; Mori, D; Aleksic, B; Ozaki, N

PSYCHIATRIC GENETICS   Vol. 28 ( 5 ) page： 90 - 93   2018.10

Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights Open Access

Kushima, I; Aleksic, B; Nakatochi, M; Shimamura, T; Okada, T; Uno, Y; Morikawa, M; Ishizuka, K; Shiino, T; Kimura, H; Arioka, Y; Yoshimi, A; Takasaki, Y; Yu, Y; Nakamura, Y; Yamamoto, M; Iidaka, T; Iritani, S; Inada, T; Ogawa, N; Shishido, E; Torii, Y; Kawano, N; Omura, Y; Yoshikawa, T; Uchiyama, T; Yamamoto, T; Ikeda, M; Hashimoto, R; Yamamori, H; Yasuda, Y; Someya, T; Watanabe, Y; Egawa, J; Nunokawa, A; Itokawa, M; Arai, M; Miyashita, M; Kobori, A; Suzuki, M; Takahashi, T; Usami, M; Kodaira, M; Watanabe, K; Sasaki, T; Kuwabara, H; Tochigi, M; Nishimura, F; Yamasue, H; Eriguchi, Y; Benner, S; Kojima, M; Yassin, W; Munesue, T; Yokoyama, S; Kimura, R; Funabiki, Y; Kosaka, H; Ishitobi, M; Ohmori, T; Numata, S; Yoshikawa, T; Toyota, T; Yamakawa, K; Suzuki, T; Inoue, Y; Nakaoka, K; Goto, YI; Inagaki, M; Hashimoto, N; Kusumi, I; Son, S; Murai, T; Ikegame, T; Okada, N; Kasai, K; Kunimoto, S; Mori, D; Iwata, N; Ozaki, N

CELL REPORTS   Vol. 24 ( 11 ) page： 2838 - 2856   2018.9

Single-cell trajectory analysis of human homogenous neurons carrying a rare RELN variant

Arioka Yuko, Shishido Emiko, Kubo Hisako, Kushima Itaru, Yoshimi Akira, Kimura Hiroki, Ishizuka Kanako, Aleksic Branko, Maeda Takuji, Ishikawa Mitsuru, Kuzumaki Naoko, Okano Hideyuki, Mori Daisuke, Ozaki Norio

TRANSLATIONAL PSYCHIATRY   Vol. 8 ( 1 ) page： 129   2018.7

Copy Number Variant in the Region of Adenosine Kinase (ADK) and Its Possible Contribution to Schizophrenia Susceptibility Open Access

Kimura, H; Kushima, I; Yohimi, A; Aleksic, B; Ozaki, N

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   Vol. 21 ( 5 ) page： 405 - 409   2018.5

Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility

Yu Yanjie, Lin Yingni, Takasaki Yuto, Wang Chenyao, Kimura Hiroki, Xing Jingrui, Ishizuka Kanako, Toyama Miho, Kushima Itaru, Mori Daisuke, Arioka Yuko, Uno Yota, Shiino Tomoko, Nakamura Yukako, Okada Takashi, Morikawa Mako, Ikeda Masashi, Iwata Nakao, Okahisa Yuko, Takaki Manabu, Sakamoto Shinji, Someya Toshiyuki, Egawa Jun, Usami Masahide, Kodaira Masaki, Yoshimi Akira, Oya-Ito Tomoko, Aleksic Branko, Ohno Kinji, Ozaki Norio

TRANSLATIONAL PSYCHIATRY   Vol. 8 ( 1 ) page： 12   2018.1

IDENTIFICATION OF RARE DISRUPTIVE VARIANTS IN VOLTAGE-GATED CHANNEL GENES (CACNA1C, CACNA1D, CACNA1S, CACNA1I) IN JAPANESE SAMPLES OF SCHIZOPHRENIA AND AUTISM SPECTRUM DISORDER USING ION TORRENT PGM PLATFORM

Wang, C; Kimura, H; Xing, J; Ishizuka, K; Kushima, I; Arioka, Y; Yoshimi, A; Nakamura, Y; Shiino, Y; Oya, Y; Takasaki, Y; Aleksic, B; Mori, D; Ozaki, N

EUROPEAN NEUROPSYCHOPHARMACOLOGY   Vol. 27   page： S341 - S342   2017.10

MUTATION SCREENING OF THE PCDH15 GENE IN PATIENTS SUFFERING FROM AUTISM SPECTRUM DISORDERS AND SCHIZOPHRENIA

Ishizuka, K; Wang, CY; Kimura, H; Xing, JR; Kushima, I; Arioka, Y; Yoshimi, A; Nakamura, Y; Oya-Ito, T; Takasaki, Y; Uno, Y; Okada, T; Mori, D; Aleksic, B; Ozaki, N

EUROPEAN NEUROPSYCHOPHARMACOLOGY   Vol. 27   page： S162 - S163   2017.10

A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility Open Access

Kimura, H; Fujita, Y; Kawabata, T; Ishizuka, K; Wang, C; Iwayama, Y; Okahisa, Y; Kushima, I; Morikawa, M; Uno, Y; Okada, T; Ikeda, M; Inada, T; Branko, A; Mori, D; Yoshikawa, T; Iwata, N; Nakamura, H; Yamashita, T; Ozaki, N

TRANSLATIONAL PSYCHIATRY   Vol. 7 ( 8 ) page： e1214   2017.8

Rare genetic variants in <i>CX3CR1</i> and their contribution to the increased risk of schizophrenia and autism spectrum disorders Open Access

Ishizuka, K; Fujita, Y; Kawabata, T; Kimura, H; Iwayama, Y; Inada, T; Okahisa, Y; Egawa, J; Usami, M; Kushima, I; Uno, Y; Okada, T; Ikeda, M; Aleksic, B; Mori, D; Someya, T; Yoshikawa, T; Iwata, N; Nakamura, H; Yamashita, T; Ozaki, N

TRANSLATIONAL PSYCHIATRY   Vol. 7 ( 8 ) page： e1184   2017.8

High-resolution copy number variation analysis of schizophrenia in Japan

Kushima, I; Aleksic, B; Nakatochi, M; Shimamura, T; Shiino, T; Yoshimi, A; Kimura, H; Takasaki, Y; Wang, C; Xing, J; Ishizuka, K; Oya-Ito, T; Nakamura, Y; Arioka, Y; Maeda, T; Yamamoto, M; Yoshida, M; Noma, H; Hamada, S; Morikawa, M; Uno, Y; Okada, T; Iidaka, T; Iritani, S; Yamamoto, T; Miyashita, M; Kobori, A; Arai, M; Itokawa, M; Cheng, MC; Chuang, YA; Chen, CH; Suzuki, M; Takahashi, T; Hashimoto, R; Yamamori, H; Yasuda, Y; Watanabe, Y; Nunokawa, A; Someya, T; Ikeda, M; Toyota, T; Yoshikawa, T; Numata, S; Ohmori, T; Kunimoto, S; Mori, D; Iwata, N; Ozaki, N

MOLECULAR PSYCHIATRY   Vol. 22 ( 3 ) page： 430 - 440   2017.3