Updated on 2023/03/31

写真a

 
ISHII, Akira
 
Organization
Graduate School of Medicine Program in Integrated Medicine Social Life Science Professor
Graduate School
Graduate School of Medicine
Graduate School of Law
Undergraduate School
School of Medicine
Title
Professor
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Degree 1

  1. 医学博士 ( 1991.3   名古屋大学 ) 

Research Interests 1

  1. Legal Medicine, Analytical Chemistry, Forensic Toxicology, Mass Spectrometry, Gas Chromatography, High-Performance Liquid Chromatography, Solid Extraction Metabolomics

Research Areas 3

  1. Others / Others  / Forensic Medicine

  2. Others / Others  / Forensic Toxicology

  3. Others / Others  / Analytical Chemistry

Current Research Project and SDGs 5

  1. ナノスケールLC/タンデム質量分析の法医学への応用

  2. Application of laser spray ionization to forensic toxicology

  3. Detection, Determination and Identification of Abused Drug by Surface Ionization Organic Mass Spectrometry.

  4. Detection and Determination of Abused Drugs by Gas Chromatography with Surface Ionization Detection

  5. Biochemistry of catecholamine-synthesizing enzymes

Research History 4

  1. Professor and Chariman, Department of Legal Medicine, Fujita Health University School of Medicine   Professor

    2001.12 - 2007.4

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    Country:Japan

  2. Associate Professor, Department of Legal Medicine and Bioethics, Nagoya Uninversity Graduate School of Medicine   Associate Professor

    1998.8 - 2001.11

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    Country:Japan

  3. Research Associate, Department of Legal Medicine, Hamamatsu University School of Medicine   Assistant

    1993.6 - 1998.7

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    Country:Japan

  4. University of California, San Francisco, Department of Neurology, Postdoctoral fellow   Postdoctral fellow

    1991.4 - 1993.5

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    Country:United States

Education 2

  1. Nagoya University   Graduate School, Division of Medicine

    1987.4 - 1991.3

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    Country: Japan

  2. Kyoto University   Faculty of Medicine

    1981.4 - 1986.3

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    Country: Japan

Professional Memberships 8

  1. 日本法医学会   評議員, 理事, 監事 2001-,2009-2013, 2015~2019, 2021-

  2. 日本法中毒学会   評議員, 理事, 理事長 2000-,2006-, 2016-2022

  3. 日本医用マススペクトル学会   評議員, 理事 1999-, 2003-2007, 2009-2013 2017-

  4. 日本質量分析学会   学会委員, 編集委員 2005-2008,2006-2008

  5. 国際法中毒学会(The International Association of Foreusic Toxicologists)

    2004.5 - 2004.6

  6. Society of Forensic Toxicology

  7. 日本生命倫理学会

  8. 日本中毒学会

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Committee Memberships 5

  1.   Chief Editor  

    2014.1 - 2016.2   

  2. Forensic Toxicology   Associate Editor  

    2011.6 - 2013.12   

  3. 日本法医学会教育研究委員会   委員  

    2009.6 - 2021.6   

  4. 日本医用マススペクトル学会年会長   第37回日本医用マススペクトル学会年会会長  

    2011.10 - 2012.10   

  5. Japanese Association of Forensic Toxicology   President  

    2016.3 - 2022.7   

Awards 2

  1. 日本法中毒学会学術奨励賞

    2000.6   日本法中毒学会  

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    Country:Japan

  2. 国際法中毒学会 Young Scientist Awards (Best Paper Section)

    1999.9   国際法中毒学会  

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    Country:Poland

 

Papers 162

  1. Identification and quantification of diphenhydramine, haloperidol, and its metabolite, reduced haloperidol in a saponified brain specimen that was immersed in the sea water for more than 10 years

    Natori Yujin, Yoshimoto Takashi, Yamamoto Toshimichi, Ishii Akira

    LEGAL MEDICINE   Vol. 61   page: 102188   2023.3

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  2. A simple and rapid method for quantifying aconitines and their metabolites in whole blood by modified QuEChERS and liquid chromatography/tandem mass spectrometry (LC/MS/MS)

    Natori Yujin, Kamioka Shoki, Yoshimoto Takashi, Ishii Akira

    FORENSIC SCIENCE INTERNATIONAL   Vol. 341   page: 111475   2022.12

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  3. The equilibrated blood sevoflurane concentrations show a rapid decrease after switching from ventilation for the human lung to cardiopulmonary bypass

    Tamura Takahiro, Mori Atsushi, Ishii Akira, Nishiwaki Kimitoshi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 1 ) page: 163 - 168   2022.2

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  4. A simple method for the determination of glyphosate, glufosinate and their metabolites in biological specimen by liquid chromatography/tandem mass spectrometry: an application for forensic toxicology

    Ohara Tomomi, Yoshimoto Takashi, Natori Yujin, Ishii Akira

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 3 ) page: 567 - 587   2021.8

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  5. One-Pot Extraction and Quantification Method for Bile Acids in the Rat Liver by Capillary Liquid Chromatography Tandem Mass Spectrometry

    Asano Tomomi, Taki Kentaro, Kitamori Kazuya, Naito Hisao, Nakajima Tamie, Tsuchihashi Hitoshi, Ishii Akira, Zaitsu Kei

    ACS OMEGA   Vol. 6 ( 12 ) page: 8588 - 8597   2021.3

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  6. Desflurane and sevoflurane concentrations in blood passing through the oxygenator during cardiopulmonary bypass: a randomized prospective pilot study

    Tamura Takahiro, Mori Atsushi, Ishii Akira, Ando Masahiko, Kubo Yoko, Nishiwaki Kimitoshi

    JOURNAL OF ANESTHESIA   Vol. 34 ( 6 ) page: 904 - 911   2020.12

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  7. RECiQ: A Rapid and Easy Method for Determining Cyanide Intoxication by Cyanide and 2-Aminothiazoline-4-carboxylic Acid Quantification in the Human Blood Using Probe Electrospray Ionization Tandem Mass Spectrometry

    Hisatsune Kazuaki, Murata Tasuku, Ogata Koretsugu, Hida Minemasa, Ishii Akira, Tsuchihashi Hitoshi, Hayashi Yumi, Zaitsu Kei

    ACS OMEGA   Vol. 5 ( 36 ) page: 23351 - 23357   2020.9

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  8. 労働現場で発生したトルエン中毒による死亡の二事例 Invited

    産業医学ジャーナル   Vol. 43 ( 5 ) page: 32 - 35   2020.9

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  9. A preliminary study of rapid-fire high-throughput metabolite analysis using nano-flow injection/Q-TOFMS

    Taki Kentaro, Noda Saki, Hayashi Yumi, Tsuchihashi Hitoshi, Ishii Akira, Zaitsu Kei

    ANALYTICAL AND BIOANALYTICAL CHEMISTRY   Vol. 412 ( 17 ) page: 4127 - 4134   2020.7

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  10. Sensitive determination of midazolam and propofol in human plasma by GC-MS/MS

    Kaki Yuki, Fujishiro Masaya, Lee Xiao-Pen, Kato Akihito, Sakamoto Yuki, Hashimoto Mari, Minohara Sawa, Hasegawa Chika, Hasegawa Iwao, Dohi Kenji, Kumazawa Takeshi, Ishii Akira, Sato Keizo, Matsuyama Takaaki

    FORENSIC TOXICOLOGY   Vol. 38 ( 2 ) page: 409 - 419   2020.7

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  11. PiTMaP: A New Analytical Platform for High-Throughput Direct Metabolome Analysis by Probe Electrospray Ionization/Tandem Mass Spectrometry Using an R Software-Based Data Pipeline

    Zaitsu Kei, Eguchi Seiichiro, Ohara Tomomi, Kondo Kenta, Ishii Akira, Tsuchihashi Hitoshi, Kawamata Takakazu, Iguchi Akira

    ANALYTICAL CHEMISTRY   Vol. 92 ( 12 ) page: 8514 - 8522   2020.6

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  12. Development and application of a forensic toxicological library for identification of 56 natural toxic substances by liquid chromatography-quadrupole time-of-flight mass spectrometry

    Ogawa Tadashi, Zaitsu Kei, Kokaji Tetsuo, Suga Kayako, Kondo Fumio, Iwai Masae, Suzuki Takayoshi, Ishii Akira, Seno Hiroshi

    FORENSIC TOXICOLOGY   Vol. 38 ( 1 ) page: 232 - 242   2020.1

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  13. Optimal inter-batch normalization method for GC/MS/MS-based targeted metabolomics with special attention to centrifugal concentration

    Zaitsu Kei, Noda Saki, Ohara Tomomi, Murata Tasuku, Funatsu Shinji, Ogata Koretsugu, Ishii Akira, Iguchi Akira

    ANALYTICAL AND BIOANALYTICAL CHEMISTRY   Vol. 411 ( 26 ) page: 6983 - 6994   2019.10

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  14. Development of "Quick-DB forensic": A total workflow from QuEChERS-dSPE method to GC-MS/MS quantification of forensically relevant drugs and pesticides in whole blood

    Kusano Maiko, Sakamoto Yuki, Natori Yujin, Miyagawa Haruhiko, Tsuchihashi Hitoshi, Ishii Akira, Zaitsu Kei

    FORENSIC SCIENCE INTERNATIONAL   Vol. 300   page: 125 - 135   2019.7

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  15. Intact metabolite profiling of mouse brain by probe electrospray ionization/triple quadrupole tandem mass spectrometry (PESI/MS/MS) and its potential use for local distribution analysis of the brain (vol 983, pg 160, 2017)

    Hayashi Yumi, Zaitsu Kei, Murata Tasuku, Ohara Tomomi, Moreau Stephane, Kusano Maiko, Tanihata Hiroshi, Tsuchihashi Hitoshi, Ishii Akira, Ishikawa Tetsuya

    ANALYTICA CHIMICA ACTA   Vol. 1031   page: 196 - 196   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.aca.2018.08.001

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  16. Metabolome analysis of the serotonin syndrome rat model: Abnormal muscular contraction is related to metabolic alterations and hyper-thermogenesis

    Zaitsu Kei, Noda Saki, Iguchi Akira, Hayashi Yumi, Ohara Tomomi, Kimura Yuya, Koketsu Yuta, Kosaki Tomoko, Kusano Maiko, Sato Takako, Ishikawa Tetsuya, Tsuchihashi Hitoshi, Suzuki Koichi, Ishii Akira

    LIFE SCIENCES   Vol. 207   page: 550 - 561   2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.lfs.2018.06.031

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  17. STR Genotyping from a Dry-Cleaned Skirt in a Sexual Assault Case

    Ogawa Hisae, Hiroshige Yuuji, Yoshimoto Takashi, Ishii Akira, Yamamoto Toshimichi

    JOURNAL OF FORENSIC SCIENCES   Vol. 63 ( 4 ) page: 1291 - 1297   2018.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1556-4029.13698

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  18. Pericardial fluid is suitable as an alternative specimen for the measurement of beta-hydroxybutyrate within 96 h after death

    Mizutani Tatsushi, Yoshimoto Takashi, Ishii Akira

    LEGAL MEDICINE   Vol. 33   page: 53 - 54   2018.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.legalmed.2018.05.004

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  19. In Vivo Real-Time Monitoring System Using Probe Electrospray Ionization/Tandem Mass Spectrometry for Metabolites in Mouse Brain

    Zaitsu Kei, Hayashi Yumi, Murata Tasuku, Yokota Kazumi, Ohara Tomomi, Kusano Maiko, Tsuchihashi Hitoshi, Ishikawa Tetsuya, Ishii Akira, Ogata Koretsugu, Tanihata Hiroshi

    ANALYTICAL CHEMISTRY   Vol. 90 ( 7 ) page: 4695 - 4701   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.analchem.7b05291

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  20. High-throughput determination of valproate in human samples by modified QuEChERS extraction and GC-MS/MS

    Mizuno Shun, Lee Xiao-Pen, Fujishiro Masaya, Matsuyama Takaaki, Yamada Miho, Sakamoto Yuki, Kusano Maiko, Zaitsu Kei, Hasegawa Chika, Hasegawa Iwao, Kumazawa Takeshi, Ishii Akira, Sato Keizo

    LEGAL MEDICINE   Vol. 31   page: 66 - 73   2018.3

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    DOI: 10.1016/j.legalmed.2018.01.002

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  21. Fatal intoxication by 5F-ADB and diphenidine: Detection, quantification, and investigation of their main metabolic pathways in humans by LC/MS/MS and LC/Q-TOFMS

    Kusano Maiko, Zaitsu Kei, Taki Kentaro, Hisatsune Kazuaki, Nakajima Jun'ichi, Moriyasu Takako, Asano Tomomi, Hayashi Yumi, Tsuchihashi Hitoshi, Ishii Akira

    DRUG TESTING AND ANALYSIS   Vol. 10 ( 2 ) page: 284 - 293   2018.2

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    DOI: 10.1002/dta.2215

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  22. Highly sensitive determination of alendronate in human plasma and dialysate using metal-free HPLC-MS/MS

    Yamada Miho, Lee Xiao-Pen, Fujishiro Masaya, Iseri Ken, Watanabe Makoto, Sakamaki Hiroshi, Uchida Naoki, Matsuyama Takaaki, Kumazawa Takeshi, Takahashi Haruo, Ishii Akira, Sato Keizo

    LEGAL MEDICINE   Vol. 30   page: 14 - 20   2018.1

  23. Intact metabolite profiling of mouse brain by probe electrospray ionization/triple quadrupole tandem mass spectrometry (PESI/MS/MS) and its potential use for local distribution analysis of the brain

    Hayashi Yumi, Zaitsu Kei, Murata Tasuku, Ohara Tomomi, Moreau Stephane, Kusano Maiko, Tanihata Hiroshi, Tsuchihashi Hitoshi, Ishii Akira, Ishikawa Tetsuya

    ANALYTICA CHIMICA ACTA   Vol. 983   page: 160 - 165   2017.8

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    DOI: 10.1016/j.aca.2017.06.047

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  24. A human genotyping trial to estimate the post-feeding time from mosquito blood meals

    Hiroshige Yuuji, Hara Masaaki, Nagai Atsushi, Hikitsuchi Tomoyuki, Umeda Mitsuo, Kawajiri Yumi, Nakayama Koji, Suzuki Koichi, Takada Aya, Ishii Akira, Yamamoto Toshimichi

    PLOS ONE   Vol. 12 ( 6 ) page: e0179319   2017.6

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    DOI: 10.1371/journal.pone.0179319

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  25. Simultaneous quantification of batrachotoxin and epibatidine in plasma by ultra-performance liquid chromatography/tandem mass spectrometry

    Shiraishi Yosuke, Ogawa Tadashi, Suzuki Takayoshi, Iwai Masae, Kusano Maiko, Zaitsu Kei, Kondo Fumio, Ishii Akira, Seno Hiroshi

    LEGAL MEDICINE   Vol. 25   page: 1 - 5   2017.3

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    DOI: 10.1016/j.legalmed.2016.12.008

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  26. Sensitive determination of picrotoxin by liquid chromatography-quadrupole time-of-flight mass spectrometry Reviewed

    Tadashi Ogawa*, Miho Tada, Hideki Hattori, Yosuke Shiraishi, Takayoshi Suzuki, Masae Iwai, Maiko Kusano, Kei Zaitsu, Akira Ishii, Hiroshi Seno

    Legal Medicine   Vol. 20   page: 8-11   2016.3

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  27. Metabolome disruption of the rat cerebrum induced by the acute toxic effects of the synthetic cannabinoid MAM-2201 Reviewed

    Kei Zaitsu, Yumi Hayashi, Kei Suzuki, Hiroshi Nakayama, Nanpei Hattori, Rina Takahara, Maiko Kusano, Hitoshi Tsuchihashia, Akira Ishii

    Life Sciences   Vol. 137 ( 15 ) page: 49-55   2015.9

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    DOI: 10.1016/j.lfs.2015.05.013

  28. High-resolution mass spectrometric determination of the synthetic cannabinoids MAM-2201, AM-2201, AM-2232, and their metabolites in postmortem plasma and urine by LC/Q-TOFMS Reviewed

    Kei Zaitsu, Hiroshi Nakayama, Mayumi Yamanaka, Kazuaki Hisatsune, Kentaro Taki, Tomomi Asano, Tooru Kamata, Munehiro Katagai, Yumi Hayashi, Maiko Kusano, Hitoshi Tsuchihashi, Akira Ishii

    International Journal of Legal Medicine   Vol. 129 ( 6 ) page: 1233-1245   2015.9

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    DOI: 10.1007/s00414-015-1257-4

  29. A case of sudden death after Japanese encephalitis vaccination Reviewed

    Yasuo Bunai, Akira Ishii, Kayoko Akaza, Atsushi Nagai, Naoki Nishida, Seiji Yamaguchi

    Legal Medicine   Vol. 17 ( 4 ) page: 279-282   2015.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.legalmed.2015.03.003

  30. Identification and quantitation of mifepristone and its N-demethyl metabolite in the plasma of an aborted fetus by liquid chromatography–quadrupole–time-of-flight–mass spectrometry (LC–Q–TOFMS) and ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS–MS) Reviewed

    Akira Ishii, Kei Zaitsu, Maiko Kusano, Tomomi Asano, Tadashi Ogawa, Hideki Hattori, Hiroshi Seno

    Forensic Toxicology   Vol. 33 ( 2 ) page: 409-412   2015.6

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    DOI: 10.1007/s11419-015-0284-7

  31. A preliminary study on postmortem interval estimation of suffocated rats by GC-MS/MS-based plasma metabolic profiling Reviewed

    Takako Sato, Kei Zaitsu, Kento Tsuboi, Masakatsu Nomura, Maiko Kusano, Noriaki Shima, Shuntaro Abe, Akira Ishii, Hitoshi Tsuchihashi, Koichi Suzuki

    Analytical Bioanalytical Chemistry   Vol. 407 ( 13 ) page: 3659-3665   2015.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00216-015-8584-7

  32. Positional isomer differentiation of synthetic cannabinoid JWH-081 by GC-MS/MS Reviewed

    Maiko Kusano, Kei Zaitsu, Hiroshi Nakayama, Junichi Nakajima, Kazuaki Hisatsune, Takako Moriyasu, Shuntaro Matsuta, Munehiro Katagi, Hitoshi Tsuchihashi, Akira Ishii

    Journal of Mass Spectrometry   Vol. 50 ( 3 ) page: 586-591   2015.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jms.3565

  33. Identification of N,N-bis(1-pentylindol-3-yl-carboxy)naphthylamine (BiPICANA) found in an herbal blend product in the Tokyo metropolitan area and its cannabimimetic effects evaluated by in vitro [35S]GTPγS binding assays Reviewed

    Jun'ichi Nakajima, Misako Takahashi, Nozomi Uemura, Takako Seto, Haruhiko Fukaya, Jin Suzuki, Masao Yoshida, Maiko Kusano, Hiroshi Nakayama, Kei Zaitsu, Akira Ishii, Takako Moriyasu, Dai Nakae

    Forensic Toxicology   Vol. 33 ( 1 ) page: 84-92   2015.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11419-014-0253-6

  34. Simple and sensitive determination of α- and β-amanitin by liquid chromatography–quadrupole time-of-flight mass spectrometry Reviewed

    Ishii, A., Tada, M., Kusano, M., Ogawa, T., Hattori, H., Seno, H., Zaitsu, K.

    Forensic Toxicology   Vol. 32 ( 2 ) page: 342-346   2014.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  35. Metabolism of the newly encountered designer drug α-pyrrolidinovalerophenone in humans: identification and quantitation of urinary metabolites Reviewed

    Noriaki Shima, Munehiro Katagi, Hiroe Kamata, Shuntaro Matsuta, Keiko Sasaki, Tohru Kamata, Hiroshi Nishioka, Akihiro Miki, Michiaki Tatsuno, Kei Zaitsu, Akira Ishii, Takako Sato, Hitoshi Tsuchihashi, Koichi Suzuki

    Forensic Toxicology   Vol. 32 ( 1 ) page: 59-67   2014.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11419-013-0202-9

  36. High-throughput analysis of ramelteon, agomelatine, and melatonin in human plasma by ultra-performance liquid chromatography–tandem mass spectrometry Reviewed

    Tadashi Ogawa, Masae Iwai, Hideki Hattori, Kei Zaitsu, Takeshi Kumazawa, Akira Ishii, Osamu Suzuki, Hiroshi Seno

    Forensic Toxicology   Vol. 32 ( 1 ) page: 126-131   2014.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11419-013-0195-4

  37. A possible role of chenodeoxycholic acid and glycine-conjugated bile acids in fibrotic steatohepatitis in a dietary rat model Reviewed

    Jia, X., Suzuki, Y., Naito, H., Yetti, H., Kitamori, K., Hayashi, Y., Kaneko, R., Nomura, M., yamori, Y., Zaitsu, K., Kato, M., Ishii, A., Nakajima, T.

    Digestive Diseases and Sciences   Vol. 59 ( 7 ) page: 1490-1501   2014.7

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  38. Metabolic profiling of urine and blood plasma in rat models of drug addiction on the basis of morphine, methamphetamine, and cocaine-induced conditioned place preference. Reviewed

    Zaitsu, K., Miyawaki, I., Bando, K., Horie, H., Shima N., Katagi, M.,Tatsuno, M., Bamba, T., SatoT., Ishii, A., Tsuchihashi, H., Suzuki, K., Fukusaki.

    Analytical Bioanalytical Chemistry   Vol. 406   page: 1339-1354   2014.2

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  39. SIMPLE AND RAPID ASSAY METHOD FOR SIMULTANEOUS QUANTIFICATION OF URINARY NICOTINE AND COTININE USING MICRO-EXTRACTION BY PACKED SORBENT AND GAS CHROMATOGRAPHY-MASS SPECTROMETRY Reviewed

    Iwai M, Ogawa T, Hattori H, Zaitsu K, Ishii A, Suzuki O, Seno H

    Nagoya Journal of medical Sciences   Vol. 75 ( 3, 4 ) page: 255-261   2013.8

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  40. Mass spectrometric differentiation of the isomers of mono-methoxyethyl- amphetamines and mono-methoxydimethylamphetamines by GC–EI–MS–MS Reviewed

    Kei Zaitsu, Haruhiko Miyagawa, Yuki Sakamoto, Shuntaro Matsuta, Kento Tsuboi, Hiroshi Nishioka, Munehiro Katagi, Takako Sato, Michiaki Tatsuno, Hitoshi Tsuchihashi, Koichi Suzuki, Akira Ishii

    Forensic Toxicology   Vol. 31   page: 292-300   2013.7

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  41. Simple and rapid quantitation of 21 bile acids in rat serum and liver by UPLC-MS-MS: Effect of high fat diet on glycine conjugates of rat bile acids Reviewed

      Vol. 75 ( 1, 2 ) page: 57-71   2013.2

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  42. A rapid and simultaneous analysis of theophylline and its metabolites in human whole blood by ultra-performance liquid chromatography-tandem mass spectrometry. Reviewed

    Ogawa, T., Hattori, T., Iwai, M., Ito, K., Itakura, K., Ishii, A., Suzuki, O., Seno, H.

    Forensic Toxicology   Vol. 30   page: 142-148   2012

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  43. Simple and rapid analysis of amatoxins using UPLC-MS-MS. Reviewed

    Nomura, M., Suzuki, Y., Kaneko, R., Ogawa, T., Hattori, H., Seno, H., Ishii, A.

    Forensic Toxicology   Vol. 30   page: 185-192   2012

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  44. Diagnosis of fulminant type 1 diabetes mellitus in an autopsy case with postmortem changes. Reviewed

    Mizutani, T., Yoshimoto, T., Kaneko, R., Ishii, A.

    Legal Medicine   Vol. 13   page: 250-253   2011

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  45. Central nervous system involvement in n-hexane polyneuropathy demonstrated by MRI and proton MR spectroscopy. Reviewed

    Hashizume A, Koike H, Kawgashira Y, Banno H, Suzuki K, Ito M, Matsuno M, Watanabe H, Tanaka F, Nakagawa S, Kaneko R, Ishii A, Subue G.

    Clinical Neurology and Neurosurgery   Vol. 113   page: 493-495   2011

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  46. Simple analysis of blonanserin, a novel antipsychotic agent, in human plasma by GC-MS Reviewed

    H Hattori, M Iwai, T Ogawa, Y Mizutani, A Ishii, O Suzuki, H Seno

    Forensic Toxicology   Vol. 28 ( 2 ) page: 105-109   2010.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11419-010-0090-1

  47. Simple analysis of alfa-amanitin and beta-amanitin in human plasma by liquid-chromatography-massspectrometry Reviewed

    M Tanahashi, R Kaneko, Y Hirata, M Hamajima, T Arinobu, T Ogawa, A Ishii

    Forensic Toxicology   Vol. 28 ( 2 ) page: 110-114   2010.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s1419-010-0098-6

  48. Sensitive analysis of blonanserin, a novel antipsychotic agent, in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry Reviewed

    T Ogawa, H Hattori, R Kaneko, K Ito, M Iwai, Y Mizutani, T Arinobu, A Ishii, O Suzuki, H Seno

    Analytical Sciences   Vol. 26   page: 1099-1102   2010

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  49. Simultaneous analysis of aconitine, mesaconitine, hypaconitine, and jesaconitine in whole blood by LC-MS-MS using a new polymer column Reviewed

    Hattori, H, Hirata, Y, Hamajima, M, Kaneko, R, Ito, K, Ishii, A, Suzuki, O, Seno, H

    Forensic Toxicology   Vol. 27 ( 1 ) page: 7-11   2009

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  50. High-throughput determination of theophyline and caffeine in human serum by conventional liquid chromatography-mass spectrometry Reviewed

    Arinobu, T, Hattori, H, Kumazawa, T, Lee, X-P, Mizutani, Y, Katase T, kojima S, Omori, T, Kaneko, R, Ishii, A, Seno, H

    Forensic Toxicology   Vol. 27 ( 1 ) page: 1-6   2009

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  51. 薬毒物中毒 Invited

    石井 晃

    現代医学   Vol. 56   page: 169-173   2008.7

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    Authorship:Lead author   Language:Japanese  

  52. Application of new mass spectrometric techniques to legal medicine Invited Reviewed

    A, Ishii, R, Kaneko, Y, Hirata, M, Hamajima

    J Mass Spectrom Soc Japan   Vol. 56 ( 3 ) page: 131-138   2008

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  53. Rapid analysis of sertraline, fluvoxamine, and paroxetine in serum specimens by LC-MS-MS using a new polymer column Reviewed

    H, Hattori, K, Ito, M, Iwai, T, Arinobu, Y, Mizutani, T, Kumazawa, A, Ishii, O, Suzuki, H, Seno

    Forensic Toxicology   Vol. 25   page: 100-103   2007

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  54. *Sensitive analysis of aconitine, hypaconitine, mesaconitine and jesaconitine in human body fluids and Aconitum tubers by LC/ESI-TOF-MS

    Kaneko, R., Hattori, S., Furuta, S., Hamamjima, M., Hirata, Y., Watanabe, K., Seno, H. and Ishii, A.

    Journal of Mass Spectrometry   Vol. 41   page: 810-814   2006

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  55. Pipette tip solid-phase extraction and gas chromatography-mass spectrometry for the determination of mequitazine in human plasma Reviewed

    T Kumazawa, Ch Hasegawa, X-P Lee, A Marumo, n Shimmen, A Ishii, H Seno, K Sato

    Talanta   Vol. 70   page: 474-478   2006

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  56. Problems in blood alcohol testing of severely injured drivers brought to emergency departments in Japan Reviewed

    Higuchi, A., Kurihara, R., Yoshimoto, T., Sano, T., Katsumata, K., Ishii, A. and Katsumata, Y.

    Legal Medicine   Vol. 7   page: 299-305   2005

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  57. Determination of paraquat and diquat in human body fluids by high-performance liquid chromatography/tandem mass spectrometry Reviewed

    Lee, X.-P., Kumazawa, T., Fujishiro, M., Hasegawa, Ch., Arinobu, T., Seno, H., Ishii, A. and Sato, K.

    Journal of Mass Spectrometry   Vol. 39   page: 1147-1152   2005

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  58. Determination of barbital in human body fluids by solid-phase microextraction and gas chromatography/mass spectrometry Reviewed

    Masuda, K., Arinobu, T., Kumazawa, T., Iwai, M., Mizudani, Y., Hattori, H., Ishii, A., Suzuki, O. and Seno, H.

    Japanese Journal of Forensic Toxicology   Vol. 23   page: 37-40   2005

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  59. Sensitive determination of acetonitrile and propionitrile in human whole blood by headspace capillary gas chromatography with cryogenic oven trapping Reviewed

    Kaneko, R., Fukui, R., Watanabe, K., Hirata, Y., Hamajima, M. and Ishii, A.

    Japanese Journal of Forensic Toxicology   Vol. 23   page: 33-36   2005

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  60. Simultaneous analysis of nitrite and nitrate in whole blood by ion chromatography Reviewed

    Suzuki, O., Watanabe, K., Okamoto, N., Nozawa, H. and Ishii, A.

    Journal of Liquid Chromatogry and Related Technologies   Vol. 28   page: 3077-3085   2004

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  61. Simultaneous determination of barbiturates in human biological fluids by direct immersion solid-phase microextraction and gas chromatography-mass spectrometry Reviewed

    Iwai, M., hattori, H., Arinobu, T., Ishii, A., Kumazawa, T., Noguchi, H., Noguchi, H., Suzuki, O. and Seno, H.

    Journal of Chromatography B   Vol. 806   page: 65-73   2004

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  62. Simple analysis of acetaminophen in human plasma by solid-phase microextraction and gas chromatography Reviewed

    Hamajima, M., Ishida, S., Hirata, Y., Hirata, K., Watanabe, K., Seno, H. and Ishii, A.

    Japanese Journal of Forensic Toxicology   Vol. 22   page: 22-26   2004

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  63. Simple analysis of amphetamines in human whole blood and urine by headspace capillary gas chromatography with large volume injection Reviewed

    Watanabe, K., Okamoto, N., Yamaguchi, I., Nozawa, H., Ishii, A. and Suzuki, O.

    Chromatographia   Vol. 58   page: 455-458   2003

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  64. Comparison of sonic spray ionization with atomospheric pressure chemical ionization as an interface of liquid chromatography-mass spectrometry for the analysis of some local anesthetics Reviewed

    Arinobu, T., Hattori, H. Ishii, A., Kumazawa, T., Lee, X.-P., Suzuki, O. and Seno, H.

    Chromatographia   Vol. 57   page: 301-307   2003

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  65. Sensitive analysis of alkyl alcohols as de- composition products of alkyl nitrites in human whole blood and urine by headspace capillary GC with cryogenic oven trapping Reviewed

    Watanabe-Suzuki, K., Nozawa, H., Suzuki, O. and Ishii, A.

    Journal of Chromatographical Sciences   Vol. 41   page: 63-66   2003

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  66. Rapid analysis of pentazocine in human plasma by liquid chromato- graphy/mass spectrometry with sonic spray ionization Reviewed

    Arinobu, T., Hattori, H., Ishii, A., Kumazawa, T., Lee, X.-P., Kojima, S., Suzuki, O. and Seno, H.

    Analytica Chimica Acta   Vol. 492   page: 249-252   2003

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  67. *Sensitive determination of pethidine in body fluids by gas chromatography-tandem mass spectrometry Reviewed

    Ishii, A., Tanaka, M., Kurihara, R., Watanabe-Suzuki, K., Kumazawa, T., Seno, H., Suzuki, O. and Katsumata, Y.

    Journal of Chromatography B   Vol. 792   page: 117-121   2003

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  68. Stability of alkyl alcohols as decomposition products of alkyl nitrites in human whole blood Reviewed

    Watanabe, K., Okamoto, N., Nozawa, H., Ishii, A., Goto, H. and Suzuki, O.

    Japanese Journal of Forensic Toxicology   Vol. 21   page: 256-261   2003

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  69. Traumatic basal subarachnoid haemorrhage caused by the impact of a golf ball: a case report Reviewed

    Watanabe-Suzuki, K., Suzuki, O., Nozawa, H. and Ishii, A.

    Medicine, Science and Law   Vol. 42   page: 174-178   2002

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  70. *Application of gas chromatography-surface ionization organic mass spectrometry to forensic toxicology Invited Reviewed

    Ishii, A., Watanabe- Suzuki, K., Seno, H., Suzuki, O. and Katsumata, Y.

    Journal of Chromatography B   Vol. 776   page: 3-15   2002

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  71. Comparison of SSI with APCI as an interface of HPLC-mass spectrometry for analysis of a drug and its metabolites Reviewed

    Arinobu, T., Hattori, H., Seno, H., Ishii, A. and Suzuki, O.

    Journal of American Society of Mass Spcetrometry   Vol. 13   page: 204-208   2002

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  72. A curious case of a car crash in which self-strangulation and lung collapse were found: A case report Reviewed

    Watanabe-Suzuki, K., Suzuki, O., Kosugi, I., Seno, H. and Ishii, A.

    Medicine, Science and Law   Vol. 42   page: 261-264   2002

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  73. Liquid chromatographic-mass spectrometric determination of haioperidol and its metabolites in human plasma and urine Reviewed

    Arinobu, T., Hattori, H., Iwai, M., Ishii, A., Kumazawa, T., Suzuki, O. and Seno, H.

    Journal of Chromatography B   Vol. 776   page: 103-113   2002

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  74. An autopsy case of a stunt man who jumped into seawater riding a motorcycle: a case report Reviewed

    Watanabe-Suzuki, K., Suzuki, O., Nozawa, H. and Ishii, A.

    Medicine, Science and Law   Vol. 43   page: 355-357   2002

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  75. An autopsy case of human remains with a numerical variation in thoraco-lumbar vertebrae Reviewed

    Nozawa, H., Suzuki-Watanabe, K., Seno, H., Ishii, A. and Suzuki, O.

    Legal Medicine   Vol. 4   page: 123-126   2002

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  76. Determination of caffeine and theophylline in human whole blood by stir bar sorptive extraction (SBSE)-thermal desorption- capillary gas chromatography-mass spectrometry Reviewed

    Kumazawa, T., Lee, X.-P., Takano, M., Seno, H., Arinobu, T., Ishii, A., Suzuki, O. and Sato, K.

    Japanese Journal of Forensic Toxicology   Vol. 20   page: 295-302   2002

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  77. Identification and characterization of 17 phenothiazine compounds by capillary high-performance liquid chromatography/fast atom bombardment mass spectrometry Reviewed

    Mizuno, Y., Sato, K., Sano, T., Kurihara, R., Kojima, T., Yamakawa, Y., Ishii, A. and Katsumata, Y.

    Legal Medicine   Vol. 4   page: 207-216   2002

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  78. Determination of cresol isomers and phenol in human body fluids by capillary gas chromatography with cryogenic oven trapping Reviewed

    Lee, X.-P., Kumazawa, T., Saito, K., Takano, M., Hattori, H., Seno, H., Ishii, A., Watanabe-Suzuki, K., Suzuki, O. and Sato, K

    Analytical Letters   Vol. 35   page: 2093-2103   2002

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  79. A case of death due to rescue action by a power shovel after being buried alive Reviewed

    Watanabe-Suzuki, K., Nozawa, H., Ishii, A., Seno, H. and Suzuki, O.

    Legal Medicine   Vol. 3   page: 241-245   2001

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  80. Sensitive determination of pethidine in body fluids by surface ionization organic mass spectrometry Reviewed

    Ishii, A., Kurihara, R., Watanabe-Suzuki, K., Kumazawa, T., Seno, H., Matsushima, H., Suzuki, O. and Katsumata, Y.

    Journal of Chromatography B   Vol. 758   page: 117-121   2001

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  81. Dopamine D2 receptor inhibition of adenylyl cyclase is abolished by acute ethanol but restored after chronic exposure (tolerance). Reviewed

    Yao, L., Asai, K., Zhan, J., Ishii, A., Fan, P., Gordon, A. S. and Diamond, I.

    Journal of Pharmacology and Experomental Therapeutics   Vol. 298   page: 833-839   2001

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  82. Sensitive determination of midazolam and identification of its two metabolites in human body fluids by column-switching capillary high-performance liquid chromatography/fast atom bombardment-mass spectrometry Reviewed

    Sano T., Sato K., Kurihara R., Mizuno Y., Kojima T., Yamakawa Y., Yamada T., Ishii A. and Katsumata Y.

    Legal Medicine   Vol. 3   page: 149-156   2001

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  83. Sensitive determination of four general anaesthetics in human whole blood by capillary gas chromatography with cryogenic oven trapping Reviewed

    Kojima T., Ishii A., Watanabe-Suzuki K., Kurihara R., Seno H., Kumazawa T., Suzuki O. and Katsumata Y.

    Journal of Chromatography B   Vol. 762   page: 103-108   2001

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  84. Sensitive determination of styrene and related compounds in human body fluids by headspace capillary gas chromatography with cryogenic oven trapping Reviewed

    Watanabe-Suzuki, K., Ishii, A., Seno, H., Takeuchi, Y. and Suzuki, O.

    Chromatographia   Vol. 54   page: 507-510   2001

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  85. *Ultrasensitive determination of phencyclidine in body fluids by surface ionization organic mass spectrometry Reviewed

    Ishii, A., Seno, H., Watanabe-Suzuki, K., Kumazawa, T., Matsushima, H., Suzuki, O. and Katsumata, Y.

    Analytical Chemistry   Vol. 72 ( 2 ) page: 404-407   2000

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  86. Determination of pentazocine in human whole blood and urine by gas chromatography/surface ionization organic mass spectrometry (jointly authored) Reviewed

    Seno, H., Kumazawa, T., Ishii, A., Matsushima, H., Watanabe-Suzuki, K. and Suzuki, O.

    Journal of Mass Spectrometry   Vol. 35   page: 33-38   2000

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  87. Analysis of phenothiazines in human body fluids by solid-phase microextraction and liquid chromatography/tandem mass spectrometry Reviewed

    Kumazawa, T., Seno, H., Watanabe-Suzuki, K., Hattori, H., Ishii, A., Sato, K. and Suzuki, O.

    Journal of Mass Spectrometry   Vol. 35   page: 1091-1099   2000

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  88. Stability of ethyl acetate in whole blood during storage under various conditions Reviewed

    Watanabe-Suzuki, K., Ishii, A., Seno, H., Kumazawa, T. and Suzuki, O.

    Japanese Journal of Forensic Toxicology   Vol. 18 ( 8 ) page: 237-243   2000

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  89. A curious autopsy case of accidental carbon monoxide poisoning in a motor vehicle Reviewed

    Kumazawa, T., Watanabe-Suzuki, K., Seno, H., Ishii, A. and Suzuki, O.

    Legal Medicine   Vol. 2   page: 181-185   2000

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  90. Simple extraction of gamma-hydroxybutyrate in human whole blood by headspace solid-phase microextraction Reviewed

    Kurihara, R., Ishii, A., Watanabe-Suzuki, K., Kumazawa, T., Suzuki, O., Seno, H. and Katsumata, Y.

    Japanese Journal of Forensic Toxicology   Vol. 19   page: 38-45   2000

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  91. Determination of triazine herbicides in human body fluids by solid-phase microextraction and capillary gas chromatography (jointly authored) Reviewed

    Kumazawa, T., Lee, X.-P., Kondo, K., Sato, K., Watanabe-Suzuki, K., Ishii, A. and Suzuki, O.

    Chromatographia   Vol. 52 ( 3/4 ) page: 195-199   2000

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  92. シアンと類似化合物の分析 Invited

    石井 晃

    現代医学   Vol. 47 ( 1 ) page: 15-21   1999.7

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  93. Ultra-sensitive method for determination of ethanol in whole blood by head space capillary gas chromatography with cryogenic oven trapping. (jointly authored) Reviewed

    Watanabe-Suzuki, K., Seno, H., Ishii, A., Kumazawa, T., Suzuki, O.

    Journal of Chromatography B   Vol. 727   page: 89-94   1999

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  94. High performance liquid chromatography / electrospray tandem mass spectrometry for phenothiazines with heavy side chains in whole blood (jointly authored) Reviewed

    H Seno, H Hattori, A Ishii, T Kumazawa, K Watanabe-Suzuki, O Suzuki

    Rapid communications in mass spectrometry   Vol. 13   page: 2394-2398   1999

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  95. 向精神薬の分析 Invited

    石井 晃, 服部秀樹

    現代医学   Vol. 47 ( 1 ) page: 7-13   1999

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  96. Identification and quantitation of cardiac glycosides in blood and urine samples by HPLC/MS/MS. (jointly authored) Reviewed

    F Guan, A Ishii, H Seno, K Watanabe-Suzuki, T Kumazawa, O Suzuki

    Analytical chemistry   Vol. 71 ( 18 ) page: 4034-4043   1999

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  97. 毒物検索システム Invited Reviewed

    石井 晃, 勝又義直

    現代医学   Vol. 46 ( 3 ) page: 467   1999

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  98. Positive- and negative-ion mass spectromery of non-steroidal antiinflammatory agents and their clean-up with Bond Elut Glass C_18 from biological samples (jointly authored) Reviewed

    Seno, H., Hattori, H., Kumazawa, T., Ishii, A., Watanabe-Suzuki, K., Suzuki, O.

    Forensic Science International   Vol. 100   page: 143-147   1999

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  99. Extraction of methylxanthines from human body fluids by solid phase microextraction. (jointly authored) Reviewed

    Kumazawa, T., Seno, H., Lee, X.-P., Ishii, A., Watanabe-Suzuki, O., Sato, K., Suzuki, O.

    Analytical Chimica Acta   Vol. 387   page: 53-60   1999

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  100. Sensitive determination of ethanol in human breath by headspace capillary gas chromatography with cryogenic oven trapping. (jointly authored) Reviewed

    Watanabe-Suzuki, K., Seno, H., Ishii, A., Kumazawa, T., Suzuki, O.

    Japanese Journal of Forensic Toxicology   Vol. 17 ( 1 ) page: 61-65   1999

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  101. Extraction of chloroform and methylene chloride in human whole blood and urine by headspace solid phase microextraction (SPME) (jointly authored) Reviewed

    H Seno, A Ishii, K Watanabe, O Suzuki, T Kumazawa

    Medicine science and law   Vol. 39 ( 4 ) page: 332-336   1999

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  102. A method for simultaneons determination of five anticoagulant rodenticides in whole blood by high-performance liquid chromatography(jointly authored) Reviewed

    Guan, F., Ishii, A., Seno, H., Watanabe, K., Kumazawa, T., Suzuki, O.

    Journal of Pharmacentical and Biomedical Analysis   Vol. 21   page: 179-185   1999

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  103. Positive-ion, negative-ion and surface ionization mass spectra of MPTP and its derivatives. Reviewed

    A Ishii, H Seno, K Watanabe-Suzuki, N Castagnoli Jr, H Inoue, T Kumazawa, O Suzuki, Y Katsumata

    Japanese journal of forensic toxicology.   Vol. 17 ( 3 ) page: 195-202   1999

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  104. Use of ion-pair reagent for HPLC-APCI-MS determination of anionic anticoagurant rodenticides in body fluids. (jointly authored) Reviewed

    Guan, F., Ishii, A., Seno, H., Watanabe-Suzuki, K., Kumazawa, T., Suzuki, O.

    Journal of Chromatography B   Vol. 731   page: 155-165   1999

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  105. Solid-phase microextraction(SPME) and GC-ECD of benzophenones for determination of benzodiazepines in urine. (jointly authored) Reviewed

    Guan, F., Seno, H., Ishii, A., Watnabe, K., Kumazawa, T., Hattori, H., Suzuki, O.

    Journal of Analytical Toxicology   Vol. 23   page: 54-61   1999

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  106. Headspace solid-phase microextraction and gas chromatographic determination of dinitroaniline herbicides in human blood, urine and environmental water. (jointly authored) Reviewed

    Guan, F., Watanabe, K., Ishii, A., Seno, H., Kumazawa, T., Hattori, H., Suzuki, O.

    Journal of Chromatography B.   Vol. 714   page: 205-213   1998

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  107. *Determination of cyanide in whole blood by capillary gas chromatography with cryogenic oven trapping. Reviewed

    Ishii, A., Seno, H., Watanabe- Suzuki, K.,Suzuki, O. and Kumazawa, T.

    Analytical Chemistry   Vol. 70 ( 22 ) page: 4873   1998

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  108. Sensitive determination of xylenes in whole blood by capillary gas chromatography with cryogenic trapping. (jointly authored) Reviewed

    Hattori, H., Iwai, M., Kurono, S., Yamada, T., Watanabe-Suzuki, K., Ishii, A., Seno, H., Suzuki, O.

    Journal of Chromatography B.   Vol. 718   page: 285-289   1998

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  109. Monoamine oxidase activities in cat fish(Parasilurs asotus)tissues. (joinyly authored) Reviewed

    Kumazawa, T., Seno, H., Ishii, A., Suzuki, O.

    Journal of Enzyme Inhibition   Vol. 13   page: 377-384   1998

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  110. Improved extraction of ethanol from human body fluids by headspace solid-phase extraction with a carboxene-polydimethylsiloxane-coated fiber. (jointly authored) Reviewed

    X-P Lee, T Kumazawa, K Sato, H Seno, A Ishii, O Suzuki

    Chomatographia   Vol. 47   page: 593-595   1998

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  111. Varying effects of ethanol on transfected cell lines. (jointly authored) Reviewed

    Asai, K., Ishii, A., Diamond, I., Gordon, A. S.

    Alcoholism-Clinical and Experimental Reseach   Vol. 22   page: 163-166   1998

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  112. Sensitive determination of ethyl ether in whole blood by capillary gas chromatography with cryogenic trapping. (jointly authored) Reviewed

    Watanabe, K., Seno, H., Ishii, A., Kumazawa, T., Hattori, H., Suzuki, O.

    Japanese Journal of Forensic Toxicology   Vol. 16 ( 1 ) page: 69-74   1998

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  113. Characterization of β-phenethylamine-induced monoamine release in rat nucleus accumbens : a microdialysis study. (jointly authored) Reviewed

    Nakamura, M., Ishii, A., Nakahara, D.

    Europian Journal of Pharmacology   Vol. 349   page: 163-169   1998

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  114. A fatal case of profenofos poisoning. (jointly authored) Reviewed

    Seno, H., Hattori, H., Kumazawa, T., Ishii, A., Watanabe, K., Suzuki, O.

    Journal of Toxicology-Clinical Toxicology   Vol. 36   page: 63-65   1998

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  115. Positive-and negative-ion mass spectrometry of alkyl derivatives of cocaine. (jointly authored) Reviewed

    Kumazawa, T., Watanabe-Suzuki, K., Seno, H., Ishii, A., Sato, K., Suzuki, O.

    Japanese Journal of Forensic Toxicology   Vol. 16 ( 3 ) page: 221-227   1998

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  116. Capillary gas chromatography with cryogenic oven temperature for headspace samples : Analysis of chloroform of methylene chloride in whole blood. (jointly authored) Reviewed

    Watanabe, K., Seno, H., Ishii, A., Suzuki, O.

    Analytical Chemistry   Vol. 69   page: 5178-5181   1997

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  117. A death case in which the victim was run over after intake of psychopharmaceutical drugs including carbamazepine. Reviewed

    Ishii, A., Seno, H., Watanabe, K., Guan, F., Suzuki, O.

    Japanese Journal of Forensic Toxicology   Vol. 15 ( 3 ) page: 226-230   1997

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  118. Simple extraction of 1-phenylethylamine in human urine by headspace solid phase microextraction. Reviewed

    Ishii, A., Seno, H., Guan, F., Wantanabe, K., Kumazawa, T., Hattori, H., Suzuki, O.

    Japanese Journal of Forensic Toxicology   Vol. 15 ( 3 ) page: 189-193   1997

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  119. Nonfatal suicidal intoxication by clozapine Reviewed

    Ishii, A., Mizoguchi, K., Kageoka, M., Seno, H., Kumazawa, T., Suzuki, O.

    Journal of Toxicology-Clinical Toxicology   Vol. 35 ( 2 ) page: 195-197   1997

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  120. Simultaneous determination of cocaethylene and cocaine in blood by gas chromatography with surface ionization detection(jointly authored) Reviewed

    Watanabe, K., Hattori, H., Nishikawa, M., Ishii, A., Kumazawa, T., Seno, H., Suzuki, O.

    Chromatographia   Vol. 44 ( 1-2 ) page: 55-58   1997

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  121. Simple analysis of diphenylmethane antihistaminics and their analogues in bodily fluids by headspace solid-phase microextraction-capillary gas chromatography(jointly authored) Reviewed

    Nishikawa, M., Seno, H., Ishii, A., Suzuki, O, Kumazawa, T., Watanabe, K., Hattori, H.

    Journal of Chromatographic Sciences   Vol. 35   page: 275-279   1997

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  122. Detection of benzodiazepines in human urine by direct immersion solid phase micro extraction and gas chromatography(jointly authored) Reviewed

    Seno, H., Kumazawa, T., Ishii, A., Watanabe, K., Hattori, H., Suzuki, O.

    Japanese Journal of Forensic Toxicology   Vol. 15 ( 1 ) page: 16-20   1997

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  123. Sensitive determination of trichloroethylene in blood and urine by capillary gas chromatography with cryogenic trapping. (jointly authored) Reviewed

    Watanabe, K., Seno, H., Ishii, A., Kumazawa, T., Hattori, H., Suzuki, O.

    Japanese Journal of Forensic Toxicology   Vol. 15 ( 3 ) page: 211-216   1997

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  124. A simple and sensitive quantitation of N, N-dimethyltryptamine by gas chromatography with surface ionization detection Reviewed

    Ishii, A., Seno, H., Suzuki, O., Hattori, H., Kumazawa, T.

    Journal of Analytical Toxicology   Vol. 21 ( 1 ) page: 36-40   1997

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  125. Simple and seusitive detection of phencyclidire in body fluids by gas chromatography with surface ionization detection Reviewed

    Ishii, A., Seno, H., Kumazawa, T., Nishikawa, M., Watanabe, K., Suzuki, O.

    International Journal of Legal Medicine   Vol. 108 ( 5 ) page: 244-247   1996

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  126. Detection of ethanol in Human body fluids by headspace solid-phase micro extraction(SPME)/capillary gas chromatography(jointly authored) Reviewed

    Kumazawa, T., Seno, H., Lee, X.-P., Ishii, A., Suzuki, O., Sato, K.

    Chromatographia   Vol. 43 ( 7-8 ) page: 393-397   1996

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  127. Drawings by an autistic adult chronicling a day in his childhood(jointly authored) Reviewed

    Ishii, T., Ishii, A., Ishii, T., Sugiyama, T.

    Visual Art Research   Vol. 22 ( 2 ) page: 47-55   1996

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  128. Simple clean-up of methanphetamine and amphetamine in human urine by direct-immersion solid phase micro extraction(DI-SPME) Reviewed

    Ishii, A., Seno, H., Kumazawa, T., Nishikawa, M., Watanabe, K., Hattori, H.,Suzuki, O.

    Japanese Journal of Forensic Toxicology   Vol. 14 ( 3 ) page: 228-232   1996

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  129. Reduction of pyrroloquinoline quinone by DT-diaphorase from Clostridium Kluyveri(jointly anthored) Reviewed

    Kumazawa, T., Suzuki, O., Seno, H., Ishii, A., Sato, K.

    Biochemical Archives   Vol. 12   page: 201-206   1996

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  130. Sensitive quantitation of clozapine in body fluids by gas chromatography with surface ionization detection Reviewed

    Ishii, A., Seno, H., Kumazawa, T., Nishikawa, M., Watanabe, K., Hatori, H., Suzuki, O.

    Japanese Journal of Forensic Toxicology   Vol. 14 ( 3 ) page: 215-220   1996

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  131. Analyses of drugs and poisous in legal medicine (jointly authored) Invited Reviewed

    Journal of the Mass Spectrometry Society of Japan   Vol. 44 ( 3 ) page: 321-333   1996

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  132. Detection of some phenothiazines by headspace solid phase microextraction and gas chromatography (jointly authored) Reviewed

    Seno, H., Kumazawa, T., Ishii, A., Nishikawa, M., Watanabe, K., Hattori, H., Suzuki, O.

    Japanese Journal of Forensic Toxicology   Vol. 14 ( 1 ) page: 30-34   1996

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  133. Analytical Toxicology (jointly authored) Invited Reviewed

    Suzuki, O., Seno, H., Ishii, A.

    Forensic Science International   Vol. 80 ( 1.2 ) page: 137-146   1996

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  134. Simple extraction of phencyclidine from human body fluids by headspace solid-phase microextraction(SPME) Reviewed

    Ishii, A., Seno, H., Kumazawa, T., Watanabe, K., Hattori, H.,Suzuki, O.

    Chromatographia   Vol. 43 ( 5-6 ) page: 331-333   1996

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  135. Extraction of local anaesthetics from human blood by direct immersion-solid phase micro extraction(SPME)(jointly authored) Invited Reviewed

    Kumazawa, T., Sato, K., Seno, H., Ishii, A., Suzuki, O.

    Chromatographia   Vol. 43 ( 1-2 ) page: 59-62   1996

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  136. Determination of some carbamate pesticides in human body fluids by headspace solid phase micro extraction and gas chromatography Reviewed

    Seno, H., Kumazawa, T., Ishii, A., Nishikawa, M., Watanabe, K., Hattori, H., Suzuki, O.

    Japanese Journal of Forensic Toxicology   Vol. 14 ( 3 ) page: 199-203   1996

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  137. Detection of maperidine (pethidine) in human blood and urine by headshace solid phase microextraction and gas chromatography (jointly authored)

    Japanese Journal of Forensic Toxicology   Vol. 13 ( 3 ) page: 211   1995

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  138. Detection of cocaine in human urine by solid-phase microexraction and capillary gas chromatography with nitrogen-phosphorus detection (jointly authored) Reviewed

    Kumazawa, T., Watanabe, K., Sato, K., Seno, H., Ishii, A., Suzuki, O.

    Japanese Journal of Forensic Toxicology   Vol. 13 ( 3 ) page: 207-210   1995

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  139. Levels of pyrrologuinoline guinone in various foods (joiutly authored) Reviewed

    Kumazawa, T., Sato, K., Seno, H., Ishii, A., Suzuki, O.

    Bichemical Jourhal   Vol. 307   page: 331-333   1995

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  140. Capilbty gas chromatograhy with four different detectors for dinitroaniline herbicdes in human body fluids (jointly authored)

    Journal of Analytical Toxicology   Vol. 19   page: 95   1995

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  141. Gas chromatography with surface ionization detection: a highly seusitius metnod for detormining undevivatized codeine and dihydrocodeine in body fluids (jointly authored)

    Journal of Chromatograpny B   Vol. 673 ( 2 ) page: 189   1995

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  142. Sensitive detection of Strychnine in biological samples by gas chromatography with surface ionization detection Reviewed

    Ishii, A., Hattori, H., Seno, H., Kumazawa, T., Suzuki, O.

    Journal of Forensic Sciences   Vol. 40 ( 3 ) page: 483-485   1995

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  143. Detection of ten local anaesthetics in human blood using solid-phase mictroextraction(SPME) and capillary gas chromatography (jointly authored)

    Japanese Journal of Forensic Toxicology   Vol. 13 ( 3 ) page: 182   1995

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  144. Simple extraction of tricyclic antidepressants in human urine by headspace solid-phase microextraction (SPME) (jointly authored)

    Japanese Journal of Forensic Toxicology   Vol. 13 ( 1 ) page: 25   1995

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  145. Positive-and negative-ion mass spectrometry of pyrazolones and pyrazolidines (jointly authored) Reviewed

    Seno H, Kumazawa T, Ishii A, Watanabe K, Suzuki O.

    Japanese Journal of Forensic Toxicology   Vol. 12 ( 3 ) page: 213   1994

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  146. Determination of diltiazem in body fluids by gas chromatography with surface ionization detection (jointly authored) Reviewed

    Japanese Journal of Forensic Toxicology   Vol. 12 ( 3 ) page: 247   1994

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  147. Determination of cocaine in body fluids by gas chromatography with surface ionization detection : comparison with nitrogen-phosphorus detection (jointly authored) Reviewed

    Hattori, H., Kurono, S., Kimura, M., Ishii, A., Suzuki, O. and Yamada, T.

    Japanese Journal of Forensic Toxicology   Vol. 12 ( 1 ) page: 26-32   1994

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  148. Determination of trihexyphenidyl in body fluids by gas chromatography with surface ionization detection

    Japanese Journal of Forensic Toxicology   Vol. 12 ( 3 ) page: 241   1994

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  149. Positive-and negative-ion mass spectrometry of seven dinitroaniline herbicides (jointly authored) Reviewed

    Kumazawa T, Sato K, Seno H, Ishii A, Suzuki O.

    Japanese Jounal of Forensic Toxicology   Vol. 12 ( 3 ) page: 228   1994

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  150. Determination of tertiary amino antitussives in Body Fluids by Gas Chromatography with Surface Ionization Detection Reviewed

    Ishii, A., Seno, H., Kumazawa, T. and Suzuki, O.

    Japanese Journal of Forensic Toxicology   Vol. 11 ( 3 ) page: 176-181   1993

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  151. Analyses of Quinolone Antimicrobials in Human Plasma by Capillary High-Performance Liquid Chromatography/Fast Atom Bombardment Mass Spectrometry (jointly authored) Reviewed

    Hattori, H., Suzuki, O., Seno, H., Ishii, A. and Yamada, T.

    Japanese Journal of Forensic Toxicology   Vol. 11 ( 3 ) page: 166-175   1993

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  152. Determination of Some Butyrophenones in Body Fluids by Gas Chromatography with Surface Ionization Detection (jointly authored) Reviewed

    Seno, H., Kumazawa, T., Ishii, A., Sato, K. and Suzuki, O.

    Japanese Journal of Legal Medicine   Vol. 47 ( 5 ) page: 367-371   1993

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  153. Determination of Aminopyrine in Body Fluids by Gas Chromatography with Surface Ionization Detection Reviewed

    Ishii, A., Hattori, H., Seno, H., Kumazawa, T., Suzuki, O.

    Japanese Journal of Forensic Toxicology   Vol. 11 ( 3 ) page: 182-186   1993

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  154. Positive and Negative ion mass spectrometry of ten xanthine derivatives and their rapid clean-up with Sep-Pak C18 cartridges from biological samples (jointly authored) Reviewed

    Kumazawa, T., Sato, K., Seno, H., Ishii, A. and Suzuki O.

    Forensic Science International   Vol. 68   page: 53-57   1993

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  155. Expression of two forms of dopamine-β-hydroxylase in COS cells. Reviewed

    Ishii, A., Kobayashi, K., Kiuchi, K. and Nagatsu, T.

    Neuroscience Letters   Vol. 125   page: 25-28   1991

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  156. The newly synthesized Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells (jointly authored) Reviewed

    Sumi, M., Kiuchi, K., Ishikawa, T., Ishii, A., Hagiwara, M., Nagatsu, T. and Hidaka, H.

    Biochemical and Biophysical Research Communication   Vol. 181   page: 968-975   1991

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  157. A selective Ca2+/calmodulin-dependent protein kinase II infibitor, KN-62, inhibits the enhanced phosphorylation and the activation of tyrosine hydroxylase by 56 mM K+ in rat pheochromocytoma PC12h cells Reviewed

    . Ishii, A., Kiuchi, K., Kobayashi, R., Sumi, M., Hidaka, H. and Nagatsu, T.

    Biochemical and Biophysical Research Communication   Vol. 176   page: 1052-1056   1991

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  158. Right-left asynmetry tyrosine hydroxylase in rat median eminence : influence of baroreflex nerves (jointly authored) Reviewed

    Alexander, N., Kaneda, N., Ishii, A., Mogi, M., Harada, M. and Nagatsu, T.

    Brain Research   Vol. 109   page: 282   1990

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  159. Effect of (6R)-and (6S)-Tetrahydrobiopterin on L, 3,4-dihydrophenylalanine(DOPA) Formation in NRK fibroblasts transfected with human tyrosine hydroxylase type 2cDNA. Reviewed

    Ishii, A., Hagihara, M., Matsuura, S., Uchida, K., Kiuchi, K., Kaneda, N., Toya, S., Kohsaka, S. and Nagatsu, T.

    Neurochemistry International   Vol. 17 ( 4 ) page: 625-632   1990

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  160. Ferrous ion actirates the less active form of human adrenal tyrosine hydroxylase Reviewed

    Ishii, A., Kiuchi, K., Matsuyama, M., Satake, T. and Nagatsu, T.

    Neurochemistry International   Vol. 16 ( 1 ) page: 59-64   1990

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  161. Tetrahydrobiopterin-dependent production of L-DOPA in NRK fibrablasts transfected with tyrosine hydroxylase cDNA : future use for intracerelral grafting (jointly authored) Reviewed

    Uchida, K., Ishii, A., Kaneda, N., Toya, S., Nagatsu, T. and Kohsaka, S.

    Neuroscience Letters   Vol. 109   page: 282-286   1990

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  162. Expression of four types of human tyrosine hydroxylase in COS cells Reviewed

    Kobayashi, K., Kiuchi, K., Ishii, A., Kaneda, N., Kurosawa, Y., Fujita, K. and Nagatsu, T.

    FEBS Letters   Vol. 238 ( 2 ) page: 431-434   1988

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Books 14

  1. 火災便覧 Reviewed

    ( Role: Contributor ,  6・2・1 (3) 火災による死因の判断)

    共立出版  2018.11  ( ISBN:978-4-320-07721-8

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    Total pages:1580   Responsible for pages:384   Language:Japanese Book type:Dictionary, encyclopedia

  2. 薬毒物情婦インデックス

    ( Role: Joint author)

    日本医事新報社  2014.11  ( ISBN:978-4-7849-4151-3

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    Total pages:716   Book type:Dictionary, encyclopedia

  3. Section 8-2-04. Surface Ionization and its application to GC-MS

    A Ishii, O Suzuki, Y Katsumata( Role: Joint author)

    Elsevier Science Ltd.  2006  ( ISBN:978-0-08-043847-4

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    Language:English

  4. II.7.7. Diazine and triazne herbicides. Drugs and Poisons in Humans. A Hadnbook of Practical Analysis (eds. Suzuki O. and Watanabe K.)

    Ishii, A., Katsumata, Y.( Role: Joint author)

    Springer-Verlag, Berlin Heidelberg  2005 

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    Language:English

  5. II.2.8. Phencyclidine. Drugs and Poisons in Humans. A Hadnbook of Practical Analysis (eds. Suzuki O. and Watanabe K.)

    Ishii, A., Katsumata, Y.( Role: Joint author)

    Springer-Verlag, Berlin Heidelberg  2005 

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    Language:English

  6. II.3.1. Phenothiaznes. Drugs and Poisons in Humans. A Hadnbook of Practical Analysis (eds. Suzuki O. and Watanabe K.)

    Ishii, A., Katsumata, Y.( Role: Joint author)

    Springer-Verlag, Berlin Heidelberg  2005 

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    Language:English

  7. ダイアジン・トリアジン系除草剤.「薬毒物分析実践ハンドブック」鈴木 修、屋敷幹雄編集

    石井 晃,勝又義直( Role: Joint author)

    じほう社  2002 

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    Language:Japanese

  8. フェノチアジン系薬物.「薬毒物分析実践ハンドブック」鈴木 修、屋敷幹雄編集

    石井 晃,勝又義直( Role: Joint author)

    じほう社  2002 

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    Language:Japanese

  9. Gas chromatography with surface ionization detection for determination of abused drugs Advances in legal medicine 3

    Ishii, A., Seno, H., Hattori, H., Watanabe, K., Suzuki, O( Role: Joint author)

    Yoyodo Printings  1997 

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    Language:English

  10. 4.15 酵素 「感情障害 基礎と臨床」 笠原 嘉、松下正明、岸本英爾 編集

    石井 晃,永津俊治( Role: Sole author)

    感情障害-基礎と臨床-  1997 

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    Language:Japanese

  11. Genes of human catecholamine-synthesizing enzymes. Parkinson's Disease. From Clinical Aspects to Molecular Basis (Nagatsu, T., Narabayashi, H., Yoshida, M. eds.)

    Nagatsu, T., Kaneda, N., Kobayashi, K., Ichinose, H., Sasaoka, T., Ishii, A., Sumi, C., Kiuchi, K., Fujita, K., Kurosawa, Y.( Role: Joint author)

    Springer Verlag  1991 

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    Language:English

  12. 7−11 ドーパミン-β-ヒドロキシラーゼ. 日本生化学会編 新生化学実験講座 第11巻「神経生化学」

    永津俊治,石井 晃( Role: Joint author)

    東京化学同人  1990 

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    Language:Japanese

  13. 7−8 チロシンヒドロキシラーゼ. 日本生化学会編 新生化学実験講座 第11巻「神経生化学」

    永津俊治,石井 晃( Role: Sole author)

    東京化学同人  1990 

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    Language:Japanese

  14. Molecular genetic approaches to the study of human catecholamine-synthesiziy euzymes (jointly authored)

    T Nagatsu, N Kaneda, K Kobayashi, H Ichinose, T Sasaoka, Ishii A, K Kiuchi, Y Kurosawa, K Fujita( Role: Joint author)

    Bioinformatics (Elsevier Science Publishers B. V. )  1989 

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    Language:English

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Presentations 1

  1. The road not taken: my career as a forensic pathologist and a forensic toxicologist Invited International conference

    A Ishii

    TIAFT Online Educational Symposium  2020.12.15  The International Association of Forensic Toxicologists

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    Event date: 2020.12

    Language:English   Presentation type:Oral presentation (invited, special)  

Works 2

  1. 終末期医療をめぐる生命倫理

    2012.6
    -
    2012.11

  2. 日本における検視と法医解剖-どのような症例が解剖の対象となるか-

    2011.6
    -
    2011.10

Research Project for Joint Research, Competitive Funding, etc. 5

  1. 大容量導入質量分析による超高感度分析法

    2006.4 - 2008.3

    上原記念生命科学財団  上原記念生命科学財団研究助成金 

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    Grant type:Competitive

  2. 培養細胞を用いた免疫機能への薬毒物の影響ー好中球の遊走を指標として−

    2006.4 - 2007.3

    日本私学振興財団  私立大学教育研究高度化推進特別補助 

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  3. 包括的薬毒物スクリーニングシステムの構築

    2005.4 - 2006.3

    日本私学振興財団  学術研究振興資金 

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    Authorship:Principal investigator  Grant type:Competitive

  4. 確度の高い死因判定のための総合的解剖システムの確立

    2005.4 - 2006.3

    日本私学振興事業団  私立大学等研究設備等補助金 

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    Grant type:Competitive

  5. オーブン冷却捕獲法による体液中揮発性薬毒物の高感度分析

    1999.4 - 2000.3

    上原記念財団  研究奨励金 

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    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 22

  1. 分解後プロテオミクス:法医学からの新規プロテオミクス

    Grant number:19K22756  2019.6 - 2023.3

    科学研究費助成事業  挑戦的研究(萌芽)

    石井 晃, 名取 雄人

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\6240000 ( Direct Cost: \4800000 、 Indirect Cost:\1440000 )

    本研究においては、ペプチド質量分析に習熟した研究協力者と共に、最新の質量分析技術を駆使して、熱中症等で上昇する尿中ミオグロビン、頸部圧迫で上昇する可能性がある血液中サイログロブリン、心不全のマーカーである血液中NT-proBNPなどについて、分解したペプチドをターゲットとした同定・定量法を確立する。同時に、死後変動の再検討も行い、死後経過時間の長い死体におけるこれらタンパク及び分解ペプチドマーカーの高感度かつ正確な同定・定量を試みる。最終的には、法医鑑定に資する体液中分解ペプチドマーカーを確立する。
    本研究では、生体試料における目的タンパクを定量し、次いで、実検体で切断されているペプチドフラグメントを同定し、法医診断に資するタンパク(ペプチド)マーカーの探索を行うことを目的とする。対象となるタンパクとしては、熱中症で上昇するミオグロビン、心不全で上昇するNT-proBNPが挙げられる。
    本年度は、昨年度に引き続き、標準尿サンプルからのミオグロビンの検出条件について検討した。法医鑑定においては、多くのサンプルが腐敗変性の影響を受けていることを勘案し、新鮮尿及び2週間室温に放置して腐敗させた尿サンプル0.25 mLにヒト組み換えミオグロビンを、終濃度10 ng/mLになるように添加し、さらに1 mlのアセトニトリルを添加して攪拌後、氷上で15分静置し、その後1,700 gで15分遠心し、沈殿を25 microLの蒸留水ないしトリプシン溶液を添加し、直ちに2×サンプルバッファーを添加して加熱変性したものを未処理サンプル、37度の水浴で60分処理後、25 microLのサンプルバッファーを添加して加熱変性したものを処理サンプルとし、SDS-PAGEを行った。その後、Western blotを行い、抗ミオグロビン抗体による染色を行った。すると、処理サンプルでミオグロビンのバンドが認められなかったのは予想通りであったが、腐敗尿では、未処理サンプルでもミオグロビンのバンドは認められなかった。そこで、同様の実験を、最大200 ng/mLまでミオグロビンを添加した尿で行ったところ、腐敗尿では、感度限界が5分の1程度に低下することがわかった。今後、種々の腐敗条件で同様の結果が得られるかを検討し、再現性の高いミオグロビン検出条件の最適化を試みる。
    本年度も、コロナ禍による登校制限などが重なり、尿中ミオグロビンの電気泳動実験が遅延したため。
    腐敗尿におけるミオグロビンの検出限界の低下は、ミオグロビン分子が、腐敗尿に含まれるタンパク成分ないし低分子物質に吸着する可能性が考えられる。昨年、免疫沈降法はミオグロビンの濃縮に不利であるという結果がでたものの、免疫沈降法を再度採用する可能性もある。また、腐敗尿を従来解剖時に依頼していた検査法で検査し、データを比較することも予定している。

  2. 高感度新規胆汁酸分析法を用いたNASH肝線維化に関わる胆汁酸種の解明

    Grant number:19K11653  2019.4 - 2023.3

    科学研究費助成事業  基盤研究(C)

    浅野 友美, 那須 民江, 石井 晃, 北森 一哉

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    より高感度に胆汁酸分析が可能なnano LC/MS/MSと呼ばれる新規質量分析法を用い、NASH肝線維化の発症および重症化に関わる胆汁酸種や組成を明らかにする。高脂肪・高コレステロール(HFC)食の摂取により、NASH進展を示すモデルラットSHRSP5/Dmcrの肝線維化には、肝臓中の胆汁酸種の毒性強度や組成が強く影響する。本研究では、発症や重症化に関わる胆汁酸種や組成変化を捉えるため、SHRSP5/Dmcrに加え、HFC食摂取により肝線維化の重症度が異なる系統基ラットSHRSPおよびWKYを用い、3系統のラットの肝線維化重症度の差と胆汁酸組成の差から、肝線維化に関与する胆汁酸を明らかにする。
    令和3年度調整済みの3系統ラットの肝臓中胆汁酸を分析した。
    データの解析は学外の専用解析ソフトが必要であり、解析ソフトの更新の都合と新型コロナ禍の影響により、データ解析を十分に進めることができなかった。このため、令和3年度は分析に留まった。
    3系統ラットの肝臓中胆汁酸の分析は終了したものの、データ解析が学外施設設置の機器でないとできない状況であった。しかし、新型コロナ禍の影響により出向を自粛したためデータ解析に遅れが生じた。
    脂肪・高コレステロール(HFC)食の摂取によりNASH病態を示すSHRSP5/Dmcrに加え、同食餌の摂取により肝線維化の重症度の異なる系統基ラットであるSHRSPおよびWKYラットの3系統ラットの肝臓中胆汁酸をプロファイリングし、肝線維化や重症化に関わる胆汁酸種や胆汁酸組成との関連を明らかにする。

  3. Accurate measurement of natural toxins in body fluids using deuterated standards and search of specific markers for the rapid diagnosis

    Grant number:18H03064  2018.4 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Ishii Akira

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    Authorship:Principal investigator 

    Grant amount:\16380000 ( Direct Cost: \12600000 、 Indirect Cost:\3780000 )

    The purpose of the present study is to develop methods for sensitive identification and precise quantification of natural toxins in human biological specimens using deuterium labeled natural toxins by deuterium exchange reactions. Although we have not obtained deuterium labeled natural toxins, we have developed two methods for screening, identifying and quantification natural toxins in human biological specimens: a screening system for 56 natural toxins by liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (LC-QTOFMS), and a sensitive quantification method for 12 plant toxins by LC-tandem mass spectrometry, combined with simple solid-phase extraction.

  4. 最新質量分析計による体液中危険ドラッグの検出・同定法の開発及び学際的検討 International coauthorship

    Grant number:15H02530  2015.4 - 2018.3

    科学研究費補助金  基盤研究(A)

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    Authorship:Principal investigator  Grant type:Competitive

  5. Application of novel mass spectrometric techniques for highly sensitive, specific and speedy identification of new psychoactive substances in human specimens

    Grant number:15H02530  2015.4 - 2018.3

    Ishii Akira

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\25870000 ( Direct Cost: \19900000 、 Indirect Cost:\5970000 )

    The aim of this project is to develop simple and comprehensive methods for determining novel abused drugs including synthetic cannabinoids by combining ultra-sensitive and/or highly specific mass spectrometers, and conventional mass spectrometers. We developed a simple method for determining several synthetic cannabinoids and their metabolites using a high-performance liquid chromatography-quadrupole time-of-flight mass spectrometer (LC-QTOFMS). The combination of an LC-QTOFMS and an LC-QTrap enabled the first identification of 5-fluoro-ADB (5-F-ADB) in the blood of a fatal intoxication case of 5-F-ADB and diphenidine. We then proposed possible metabolic pathways of the compounds. We are now investigating the difference of 5-F-ADB levels among organs in which the expression levels of carboxyesterase differ.

  6. New prevention strategies for non-alcoholic steatohepatitis - a study on the importance of blood pressure and nutritional management

    Grant number:15H04788  2015.4 - 2018.3

    NASU Tamie

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    We investigated the mechanism that underlies the progression of hypertension-associated NASH by comparing differences in HFC diet-induced NASH among hypertensive SHR and SHRSP5/Dmcr, and normotensive WKY. The diet induced severe NASH in the hypertensive rats, whereas it only caused mild NASH in the normotensive rats. Increased activation of TGFβ/MAPK pathway was observed in the hypertensive rats; it suppressed nrf2 pathway in the hypertensive rats and led to lower increases in the hepatic level of HO-1. These signaling pathways might play crucial roles in the development of hypertension-associated NASH.
    We also investigated whether antihypertensive drug suppress HFC-induced NASH in hypertensive SHR rats. It suppressed HFC-induced NASH in the liver of SHR rats. It significantly suppressed HFC-induced increases of inflammation- and fibrosis-related molecular markers. Thus, intervention of antihypertensive drug might be important in the prevention of NASH.

  7. Metabolic profiling analysis of rat administered natural toxins

    Grant number:15K08889  2015.4 - 2018.3

    OGAWA Tadashi

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    For the purpose of clarifying influences, toxicities and action mechanisms given by administration of natural toxins in the living body, internal metabolism profiling analyses were worked on rat. Even though establishment of connected evaluation method of metabolomics analysis and iTRAQ protein expression analysis is uncompleted, various fundamental data of metabolic profiling analyses of rat administered natural toxins were obtained by GC-MS/MS and LC-QTOF-MS.

  8. バイオマーカーとしての胆汁酸の法医学的応用

    Grant number:24659337  2012.4 - 2016.3

    科学研究費補助金 

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    Authorship:Principal investigator 

  9. 新しいフーリエ変換ーリニアイオントラップ質量分析計の法医学への応用

    Grant number:23390183  2011.4 - 2015.8

    科学研究費補助金  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Competitive

  10. ナノスケール高速液体クロマトグラフィー/質量分析計の法医学への応用

    Grant number:18209025  2006.4 - 2010.3

    科学研究費補助金  基盤研究(A)

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    Authorship:Principal investigator  Grant type:Competitive

  11. 固相マイクロ抽出法による新規乱用薬物のスクリーニング分析

    Grant number:17590587  2005.4 - 2007.3

    科学研究費補助金  基盤研究(C)

    浜島 誠

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  12. 薬毒物の作用機序の解析に有用な新しい質量分析法

    Grant number:15659156  2003.4 - 2006.3

    科学研究費補助金 

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    Authorship:Principal investigator  Grant type:Competitive

  13. Application of high-performance liquid chromatography/laser spray mass spectrometry to legal medicine

    Grant number:14207023  2002.4 - 2006.3

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(A)

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    Authorship:Principal investigator  Grant type:Competitive

  14. Rapid screening of inorganic poisons by column-switching ion chromatography

    Grant number:13557037  2001.4 - 2004.3

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(B)

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    Authorship:Principal investigator  Grant type:Competitive

  15. Sensitive analysis for drugs-of-abuse in human body fluids by GC/MS/MS

    Grant number:12670391  2000.4 - 2002.3

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(C)

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    Authorship:Principal investigator  Grant type:Competitive

  16. New approach for drug monitoring by using human sweat secreted

    Grant number:11559008  1999.4 - 2002.3

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(B)

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    Authorship:Coinvestigator(s) 

  17. Establishment of forensic molecular genetic analyzing method using the rapid detection allele-specific MVR-PCR

    Grant number:11670411  1999.4 - 2001.3

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(C)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  18. HPLC/タンデムMSによるドーピング薬物の迅速高感度検出法の確立

    Grant number:10770188  1998.4 - 2000.3

    科学研究費補助金  奨励研究(A)

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    Authorship:Principal investigator  Grant type:Competitive

  19. Development of surface ionization organic mass spectrometer (SIOMS) for the application to forensic toxicology

    Grant number:09307008  1997.4 - 2000.3

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(A)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  20. マイクロ固相抽出(SPME)法による体液中乱用薬物の高感度検出法

    Grant number:08770308  1996.4 - 1997.3

    科学研究費補助金  奨励研究(A)

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    Authorship:Principal investigator 

  21. Molecular mechanism of alcoholism : Ethanol and cell signaling

    Grant number:08044264  1996.4 - 1997.3

    Grant-in-Aid for Scientific Research 

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  22. トリカブト毒成分(アコニチン)HPLC/MSによる高感度分析

    Grant number:06770317  1994.4 - 1995.3

    科学研究費補助金  奨励研究(A)

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    Authorship:Principal investigator  Grant type:Competitive

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Teaching Experience (On-campus) 5

  1. Legal Medicine (for Medical Students)

    2011

  2. 法医学(医学部)

    2011

  3. Medical Law (YLP)

    2011

  4. 基礎セミナーB

    2011

  5. First Year Seminar B

    2011

Teaching Experience (Off-campus) 5

  1. 法医学

    2009.4 名古屋市消防学校)

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    Level:Other 

  2. 法医学(中毒)

    2009.4 藤田保健衛生大学医学部)

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    Level:Undergraduate (specialized) 

  3. 法医学(中毒)

    2009.4 Kyoto University)

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    Level:Undergraduate (specialized) 

  4. 法医学(性・妊娠の法医学)

    2009.4 - 2015.3 昭和大学医学部)

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    Level:Undergraduate (specialized) 

  5. 法医学(異常環境)

    2008.4 - 2009.3 浜松医科大学)