岡山大学医歯学研究科　第一病理（病態探究医学）　助手

2005.4 - 2005.7

日本組織細胞化学会

American Physiological Society

American Association for Cancer Research

日本過酸化脂質・抗酸化物質学会

6th Biennial Meeting of SFRR (Society for Free Radical Research) Asia, Informa Healthcare Prestigious Poster Award

2013.10   SFRR Asia  

5th Biennial Meeting of SFRR (Society for Free Radical Research) Asia, SFRR Japan Young Investigator Award

2011.9   SFRR Japan  

第64回日本酸化ストレス学会学術奨励賞

2011.7   日本酸化ストレス学会  

SFRR Japan Young Investigator Award 2010

2010.11   Society for Free Radical Research Japan  

Travel award

2007.4   Second Congress of International BioIron Society  

Asbestos-induced mesothelial injury and carcinogenesis: Involvement of iron and reactive oxygen species Invited Reviewed

Okazaki Yasumasa

PATHOLOGY INTERNATIONAL   Vol. 72 ( 2 ) page： 83 - 95   2022.2

Enhancement of ethanol production and cell growth in budding yeast by direct irradiation of low-temperature plasma Invited Reviewed International journal

Tanaka, H; Matsumura, S; Ishikawa, K; Hashizume, H; Ito, M; Nakamura, K; Kajiyama, H; Kikkawa, F; Ito, M; Ohno, K; Okazaki, Y; Toyokuni, S; Mizuno, M; Hori, M

JAPANESE JOURNAL OF APPLIED PHYSICS   Vol. 61 ( SA )   2022.1

Tetrachloroaurate (III)-induced oxidation increases non-thermal plasma-induced oxidative stress. Reviewed International journal

Okazaki Y, Sasaki K, Ito N, Tanaka H, Matsumoto KI, Hori M, Toyokuni S

Free radical research   Vol. 56 ( 1 ) page： 17 - 27   2022.1

Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient Reviewed International journal

Yogosawa Satomi, Ohkido Makiko, Horii Takuro, Okazaki Yasumasa, Nakayama Jun, Yoshida Saishu, Toyokuni Shinya, Hatada Izuho, Morimoto Mitsuru, Yoshida Kiyotsugu

COMMUNICATIONS BIOLOGY   Vol. 4 ( 1 ) page： 1204   2021.10

Plasma-activated Ringer's lactate solution inhibits the cellular respiratory system in HeLa cells Reviewed International journal

Tanaka, H; Maeda, S; Nakamura, K; Hashizume, H; Ishikawa, K; Ito, M; Ohno, K; Mizuno, M; Motooka, Y; Okazaki, Y; Toyokuni, S; Kajiyama, H; Kikkawa, F; Hori, M

PLASMA PROCESSES AND POLYMERS   Vol. 18 ( 10 )   2021.10

Low temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified. Reviewed International journal

Tanaka H, Hosoi Y, Ishikawa K, Yoshitake J, Shibata T, Uchida K, Hashizume H, Mizuno M, Okazaki Y, Toyokuni S, Nakamura K, Kajiyama H, Kikkawa F, Hori M

Scientific reports   Vol. 11 ( 1 ) page： 18488   2021.9

Non-thermal plasma-induced DMPO-OH yields hydrogen peroxide Reviewed International journal

Okazaki Yasumasa, Tanaka Hiromasa, Matsumoto Ken-Ichiro, Hori Masaru, Toyokuni Shinya

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 705   page： 108901   2021.7

The therapeutic potential of curcumin in alleviating N-diethylnitrosamine and iron nitrilotriacetate induced renal cell tumours in mice via inhibition of oxidative stress: Implications for cancer chemoprevention Reviewed International coauthorship International journal

Iqbal Mohammad, Shah Muhammad Dawood, Vun-Sang Senty, Okazaki Yasumasa, Okada Shigeru

BIOMEDICINE & PHARMACOTHERAPY   Vol. 139   page： 111636   2021.7

L-Dehydroascorbate efficiently degrades non-thermal plasma-induced hydrogen peroxide Reviewed International journal

Okazaki Yasumasa, Ishidzu Yuuri, Ito Fumiya, Tanaka Hiromasa, Hori Masaru, Toyokuni Shinya

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 700   page： 108762   2021.3

Induction of cancer cell-specific ferroptosis by non-thermal plasma exposure Invited Reviewed

Okazaki Yasumasa, Toyokuni Shinya

JAPANESE JOURNAL OF APPLIED PHYSICS   Vol. 59 ( 11 )   2020.11

Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate Bioengineering Invited Reviewed International journal

Toyokuni Shinya, Kong Yingyi, Cheng Zhen, Sato Kotaro, Hayashi Shotaro, Ito Fumiya, Jiang Li, Yanatori Izumi, Okazaki Yasumasa, Akatsuka Shinya

CANCERS   Vol. 12 ( 11 ) page： 3320   2020.11

Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and beta-catenin induction in mesothelium Reviewed International journal

Ito Fumiya, Yanatori Izumi, Maeda Yuki, Nimura Kenta, Ito Satoki, Hirayama Tasuku, Nagasawa Hideko, Kohyama Norihiko, Okazaki Yasumasa, Akatsuka Shinya, Toyokuni Shinya

REDOX BIOLOGY   Vol. 36   page： 101616   2020.9

Overexpression of miR-199/214 is a distinctive feature of iron-induced and asbestos-induced sarcomatoid mesothelioma in rats Reviewed International journal

Okazaki Yasumasa, Chew Shan Hwu, Nagai Hirotaka, Yamashita Yoriko, Ohara Hiroki, Jiang Li, Akatsuka Shinya, Takahashi Takashi, Toyokuni Shinya

CANCER SCIENCE   Vol. 111 ( 6 ) page： 2016 - 2027   2020.6

Frequent homozygous deletion of Cdkn2a/2b in tremolite-induced malignant mesothelioma in rats Reviewed

Okazaki Yasumasa, Misawa Nobuaki, Akatsuka Shinya, Kohyama Norihiko, Sekido Yoshitaka, Takahashi Takashi, Toyokuni Shinya

CANCER SCIENCE   Vol. 111 ( 4 ) page： 1180 - 1192   2020.4

Mth1 deficiency provides longer survival upon intraperitoneal crocidolite injection in female mice Reviewed International journal

Funahashi Satomi, Okazaki Yasumasa, Akatsuka Shinya, Takahashi Takashi, Sakumi Kunihiko, Nakabeppu Yusaku, Toyokuniaf Shinya

FREE RADICAL RESEARCH   Vol. 54 ( 2-3 ) page： 195 - 205   2020.3

Oxidative stress-dependent and -independent death of glioblastoma cells induced by non-thermal plasma-exposed solutions Reviewed International journal

Tanaka Hiromasa, Mizuno Masaaki, Katsumata Yuko, Ishikawa Kenji, Kondo Hiroki, Hashizume Hiroshi, Okazaki Yasumasa, Toyokuni Shinya, Nakamura Kae, Yoshikawa Nobuhisa, Kajiyama Hiroaki, Kikkawa Fumitaka, Hori Masaru

SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page： 13657   2019.9

L-Dehydroascorbic acid recycled by thiols efficiently scavenges non-thermal plasma-induced hydroxyl radicals Reviewed International journal

Okazaki Yasumasa, Tanaka Hiromasa, Hori Masaru, Toyokuni Shinya

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 669   page： 87 - 95   2019.7

Twist1 was detected in mesenchymal cells of mammary fibroadenoma and invasive components of breast carcinoma in rats Reviewed

Funahashi Satomi, Okazaki Yasumasa, Nagai Hirotaka, Chew Shan Hwu, Ogawa Kumiko, Toyoda Takeshi, Cho Young-Man, Toyokuni Shinya

JOURNAL OF TOXICOLOGIC PATHOLOGY   Vol. 32 ( 1 ) page： 19 - 26   2019

Glioblastoma Cell Lines Display Different Sensitivities to Plasma-Activated Medium Reviewed International journal

Tanaka Hiromasa, Mizuno Masaaki, Ishikawa Kenji, Takeda Keigo, Hashizume Hiroshi, Nakamura Kae, Utsumi Fumi, Kajiyama Hiroaki, Okazaki Yasumasa, Toyokuni Shinya, Akiyama Shinichi, Maruyama Shoichi, Kikkawa Fumitaka, Hori Masaru

IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES   Vol. 2 ( 2 ) page： 99 - 102   2018.3

Phlebotomy as a preventive measure for crocidolite-induced mesothelioma in male rats Reviewed

Ohara Yuuki, Chew Shan-Hwu, Shibata Takahiro, Okazaki Yasumasa, Yamashita Kyoko, Toyokuni Shinya

CANCER SCIENCE   Vol. 109 ( 2 ) page： 330 - 339   2018.2

A fluorescent metal-sensor study provides evidence for iron transport by transcytosis in the intestinal epithelial cells Reviewed International coauthorship

Ma Yuxiang, Okazaki Yasumasa, Glass Jonathan

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   Vol. 62 ( 1 ) page： 49 - 55   2018.1

Global overexpression of divalent metal transporter 1 delays crocidolite-induced mesothelial carcinogenesis in male mice Reviewed International journal

Funahashi Satomi, Okazaki Yasumasa, Nishiyama Takahiro, Ohyoshi Hidekazu, Yasui Hiroyuki, Nishida Kazuki, Matsui Shigeyuki, Toyokuni Shinya

FREE RADICAL RESEARCH   Vol. 52 ( 9 ) page： 1030 - 1039   2018

Role of catalytic iron and oxidative stress in nitrofen-induced congenital diaphragmatic hernia and its amelioration by Saireito (TJ-114) Reviewed

Hirako Shima, Tsuda Hiroyuki, Ito Fumiya, Okazaki Yasumasa, Hirayama Tasuku, Nagasawa Hideko, Nakano Tomoko, Imai Kenji, Kotani Tomomi, Kikkawa Fumitaka, Toyokuni Shinya

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   Vol. 61 ( 3 ) page： 176 - 182   2017.11

Astaxanthin ameliorates ferric nitrilotriacetate-induced renal oxidative injury in rats Reviewed

Okazaki Yasumasa, Okada Shigeru, Toyokuni Shinya

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   Vol. 61 ( 1 ) page： 18 - 24   2017.7

Iron and thiol redox signaling in cancer: An exquisite balance to escape ferroptosis Invited Reviewed International journal

Toyokuni Shinya, Ito Fumiya, Yamashita Kyoko, Okazaki Yasumasa, Akatsuka Shinya

FREE RADICAL BIOLOGY AND MEDICINE   Vol. 108   page： 610 - 626   2017.7

Protoporphyrin IX regulates peripheral benzodiazepine receptor associated protein 7 (PAP7) and divalent metal transporter 1 (DMT1) in K562 cells. Reviewed International coauthorship International journal

Okazaki Y, Glass J

Biochemistry and biophysics reports   Vol. 10   page： 26 - 31   2017.7

Non-thermal plasma induces a stress response in mesothelioma cells resulting in increased endocytosis, lysosome biogenesis and autophagy Reviewed International coauthorship International journal

Shi Lei, Ito Fumiya, Wang Yue, Okazaki Yasumasa, Tanaka Hiromasa, Mizuno Masaaki, Hori Masaru, Hirayama Tasuku, Nagasawa Hideko, Richardson Des R., Toyokuni Shinya

FREE RADICAL BIOLOGY AND MEDICINE   Vol. 108   page： 904 - 917   2017.7

Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics Reviewed International journal

Yoshimaru Tetsuro, Aihara Keisuke, Komatsu Masato, Matsushita Yosuke, Okazaki Yasumasa, Toyokuni Shinya, Honda Junko, Sasa Mitsunori, Miyoshi Yasuo, Otaka Akira, Katagiri Toyomasa

SCIENTIFIC REPORTS   Vol. 7 ( 1 ) page： 1821   2017.5

Rheostatic CD44 isoform expression and its association with oxidative stress in human malignant mesothelioma Reviewed International journal

Chew Shan Hwu, Okazaki Yasumasa, Akatsuka Shinya, Wang Shenqi, Jiang Li, Ohara Yuuki, Ito Fumiya, Saya Hideyuki, Sekido Yoshitaka, Toyokuni Shinya

FREE RADICAL BIOLOGY AND MEDICINE   Vol. 106   page： 91 - 99   2017.5

Protein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin-containing protein inhibitor

Shikata Yuki, Yoshimaru Tetsuro, Komatsu Masato, Katoh Hiroto, Sato Reiko, Kanagaki Shuhei, Okazaki Yasumasa, Toyokuni Shinya, Tashiro Etsu, Ishikawa Shumpei, Katagiri Toyomasa, Imoto Masaya

CANCER SCIENCE   Vol. 108 ( 4 ) page： 785 - 794   2017.4

Biphasic effects of l-ascorbate on the tumoricidal activity of non-thermal plasma against malignant mesothelioma cells. Reviewed

Shi L, Wang Y, Ito F, Okazaki Y, Tanaka H, Mizuno M, Hori M, Richardson DR, Toyokuni S.

Arch Biochem Biophys.   Vol. 605   page： 109-116   2016.9

Role of hemoglobin and transferrin in multi-wall carbon nanotube-induced mesothelial injury and carcinogenesis. Reviewed

Wang Y, Okazaki Y, Shi L, Kohda H, Tanaka M, Taki K, Nishioka T, Hirayama T, Nagasawa H, Yamashita Y, Toyokuni S

Cancer Sci   Vol. 107 ( 3 ) page： 250-257   2016.3

Asbestos and multi-walled carbon nanotubes generate distinct oxidative responses in inflammatory cells. Reviewed

Funahashi S, Okazaki Y, Ito D, Asakawa A, Nagai H, Tajima M, Toyokuni S.

J Clin Biochem Nutr   Vol. 56 ( 2 ) page： 111-117   2015.3

Plasma Medical Science for Cancer Therapy: Toward Cancer Therapy Using Nonthermal Atmospheric Pressure Plasma Invited Reviewed

*Tanaka H, Mizuno M, Ishikawa K, Takeda K, Nakamura K, Utsumi F, Kajiyama H, Kano H, Okazaki Y, Toyokuni S, Maruyama S, Kikkawa F, Hori M.

IEEE TRANSACTIONS ON PLASMA SCIENCE   Vol. 42 ( 12 ) page： 3760-3764   2014.12

Direct exposure of non-equilibrium atmospheric pressure plasma confers simultaneous oxidative and ultraviolet modifications in biomolecules. Reviewed

Okazaki Y, Wang Y, Tanaka H, Mizuno M, Nakamura K, Kajiyama H, Kano H, Uchida K, Kikkawa F, Hori M, *Toyokuni S.

J Clin Biochem Nutr.   Vol. 55 ( 3 ) page： 207-215   2014.11

Rat model demonstrates a high risk of tremolite but a low risk of anthophyllite for mesothelial carcinogenesis. Reviewed

Aierken D, Okazaki Y, Chew SH, Sakai A, Wang Y, Nagai H, Misawa N, Kohyama N, *Toyokuni S

Nagoya J Med Sci   Vol. 76 ( 1-2 ) page： 149-160   2014.2

Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production. Reviewed

Chew SH, Okazaki Y, Nagai H, Misawa N, Akatsuka S, Yamashita K, Jiang L, Yamashita Y, Noguchi M, Hosoda K, Sekido Y, Takahashi T, *Toyokuni S

Carcinogenesis   Vol. 35 ( 1 ) page： 164-172   2014.1

Deferasirox induces mesenchymal-epithelial transition in crocidolite-induced mesothelial carcinogenesis in rats Reviewed

Nagai H, Okazaki Y, Chew SH, Misawa N, Yasui H, *Toyokuni S

Cancer Prev Res (Phila)   Vol. 6 ( 11 ) page： 1222-1230   2013.11

Intraperitoneal administration of tangled multiwalled carbon nanotubes of 15 nm in diameter does not induce mesothelial carcinogenesis in rats Reviewed

Nagai H, Okazaki Y, Chew SH, Misawa N, Miyata Y, Shinohara H, *Toyokuni S

Pathol Int   Vol. 63 ( 9 ) page： 457-462   2013.9

CD146 and insulin-like growth factor 2 mRNA-binding protein 3 predict prognosis of asbestos-induced rat mesothelioma Reviewed

Okazaki Y, Nagai H, Chew SH, Li J, Funahashi S, Tsujimura T, *Toyokuni S

Cancer Sci   Vol. 104 ( 8 ) page： 989-995   2013.5

Metamorphosis of mesothelial cells with active horizontal motility in tissue culture Reviewed

Nagai H, Chew SH, Okazaki Y, Funahashi S, Namba T, Kato T, Enomoto A, Jiang L, Akatsuka S, *Toyokuni S

Sci Rep   ( 3 ) page： 1144   2013.1

Bovine lactoferrin ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats Reviewed

Okazaki Y, Kono I, Kuriki T, Funahashi S, Fushimi S, Iqbal M, Okada S, *Toyokuni S

J Clin Biochem Nutr   Vol. 51 ( 2 ) page： 84-90   2012.9

Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer. Reviewed

Akatsuka S, Yamashita Y, Ohara H, Liu YT, Izumiya M, Abe K, Ochiai M, Jiang L, Nagai H, Okazaki Y, Murakami H, Sekido Y, Arai E, Kanai Y, Hino O, Takahashi T, Nakagama H, *Toyokuni S.

PLoS One   Vol. 7 ( 8 ) page： e43403   2012.8

*DMT1 (IRE) expression in intestinal and erythroid cells is regulated by peripheral benzodiazepine receptor-associated protein 7. Reviewed

Okazaki Y, Ma Y, Yeh M, Yin H, Li Z, Yeh KY, *Glass J.

Am J Physiol Gastrointest Liver Physiol.   Vol. 302 ( 10 ) page： G1180-1190   2012.5

Diameter and rigidity of multi-walled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis Reviewed

Nagai H, Okazaki Y, Chew SH, Misawa N, Yamashita Y, Akatsuka S, Ishihara T, Yamashita K, Yoshikawa Y, Yasui H, Jiang L, Ohara H, Takahashi T, Ichihara G, Kostarelos K, Miyata Y, Shinohara H, *Toyokuni S.

Proc Natl Acad Sci USA   Vol. 108 ( 49 ) page： E1330-1338   2011.12

Asbestos surface provides a niche for oxidative modification Reviewed

Nagai H, Ishihara T, Lee WH, Ohara H, Okazaki Y, Okawa K, *Toyokuni S.

Cancer Sci   Vol. 102 ( 12 ) page： 2118-2125   2011.12

Systemic but asymptomatic transthyretin amyloidosis 8 years after domino liver transplantation. Reviewed

*Koike H, Kiuchi T, Iijima M, Ueda M, Ando Y, Morozumi S, Tomita M, Kawagashira Y, Watanabe H, Katsuno M, Shimoyama Y, Okazaki Y, Kamei H, *Sobue G.

J Neurol Neurosurg Psychiatry.   Vol. 82 ( 11 ) page： 1287-1290   2011.11

miR-375 Is Activated by ASH1 and Inhibits YAP1 in a Lineage-Dependent Manner in Lung Cancer Reviewed

Nishikawa E, *Osada H, Okazaki Y, Arima C, Tomida S, Tatematsu Y, Taguchi A, Shimada Y, Yanagisawa K, Yatabe Y, Toyokuni S, Sekido Y, *Takahashi T

Cancer Res   Vol. 71 ( 19 ) page： 6165-6173   2011.10

Dietary fish oil promotes colonic apoptosis and mitochondrial proton leak in oxidatively stressed mice Reviewed

Fan YY, Ran Q, Toyokuni S, Okazaki Y, Callaway ES, Lupton JR, *Chapkin RS

Cancer Prev Res (Phila)   Vol. 8   page： 1267-1274   2011.8

Mechanisms of Asbestos-Induced Carcinogenesis Invited Reviewed

Nippon Eiseigaku Zasshi, Japanese Journal of Hygiene   Vol. 66 ( 3 ) page： 562-567   2011.5

Stage-specific roles of fibulin 5 during oxidative stress-induced renal carcinogenesis in rats Reviewed

Ohara S, Akatsuka S, Nagai H, Liu Y-T, Jiang L, Okazaki Y, Yamashita Y, Nakamura T, *Toyokuni S.

Free Radical Res.   Vol. 45 ( 2 ) page： 211-220   2011.2

A beverage containing fermented black soybean ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats Reviewed

Okazaki Y, Iqbal M, Kawakami N, Yamamoto Y, *Toyokuni S, Okada S.

J Clin Biochem Nutr   Vol. 47 ( 3 ) page： 198-207   2010.11

Suppression of SLC11A2 expression is essential to maintain duodenal integrity during dietary iron overload. Reviewed

Shirase T, Mori K, Okazaki Y, Itoh K, Yamamoto M, Tabuchi M, Kishi F, Jiang L, Akatsuka S, Nakao K, *Toyokuni S.

Am J Pathol   Vol. 177 ( 2 ) page： 677-685   2010.8

Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma. Reviewed

Hu Q, Akatsuka S, Yamashita Y, Ohara H, Nagai H, Okazaki Y, Takahashi T, *Toyokuni S.

Lab Invest.   Vol. 90 ( 3 ) page： 360-373   2010.3

壊死と扁平上皮化生を伴う耳下腺Warthin 腫瘍の1例 Reviewed

岡崎泰昌、中本周、竹内裕一、能登原憲司、岡田茂

鳥取医学雑誌   Vol. 37 ( 1/2 ) page： 20-23   2009.6

Curcumin attenuates oxidative damage in animals treated with a renal carcinogen, ferric nitrilotriacetate (Fe-NTA): implications for cancer prevention. Reviewed

*Iqbal M, Okazaki Y, Okada S.

Mol Cell Biochem   Vol. 324 ( (1-2) ) page： 157-164   2009.4

Pathophysiology of sepsis and recent patents on the diagnosis, treatment and prophylaxis for sepsis. Invited Reviewed

Okazaki Y, *Matsukawa A

Recent Pat Inflamm Allergy Drug Discov   Vol. 3 ( 1 ) page： 26-32   2009.1

Probucol modulates iron nitrilotriacetate (Fe-NTA)-dependent renal carcinogenesis and hyperproliferative response: diminution of oxidative stress. Reviewed

*Iqbal M, Okazaki Y, Okada S.

Mol Cell Biochem   Vol. 304 ( 1-2 ) page： 61-69   2007.10

Suppressive effects of dietary curcumin on the increased activity of renal ornithine decarboxylase in mice treated with a renal carcinogen, ferric nitrilotriacetate. Reviewed

Okazaki Y, Iqbal M, *Okada S.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease   Vol. 1740 ( 3 ) page： 357-366   2005.6

脾原発の炎症性筋線維芽腫瘍の１例 Reviewed

中本周、岡崎泰昌、能登原憲司

岡山外科病理雑誌   Vol. 41 ( 1/2 ) page： 24-25   2004.12

膵solid pseudopapillary tumor の１例 Reviewed

大森昌子、岡崎泰昌、秋田みどり、井上博文、藤田勝、松岡博美、森下由美子、濱崎周次

日本臨床細胞学会　岡山支部会誌   Vol. 23   page： 37-38   2004

Nitroglycerin, a nitric oxide generator attenuates ferric nitrilotriacetate-induced renal oxidative stress, hyperproliferative response and necrosis in ddY mice. Reviewed

Iqbal M, Okazaki Y, Sharma SD, *Okada S.

Biochimica et Biophysica Acta (BBA) - General Subjects,   Vol. 1623 ( 2-3 ) page： 98-108   2003.10

In vitro curcumin modulates ferric nitrilotriacetate (Fe-NTA) and hydrogen peroxide (H2O2)-induced peroxidation of microsomal membrane lipids and DNA damage. Reviewed

Iqbal M, Okazaki Y, *Okada S.

Teratog Carcinog Mutagen.   Vol. Suppl. ( 1 ) page： 151-160   2003.2

Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity. Reviewed

Iqbal M, Sharma SD, Okazaki Y, Fujisawa M, *Okada S.

Pharmacol Toxicol.   Vol. 92 ( 1 ) page： 33-38   2003.1

鼻道分泌液細胞診が有用であった涙囊原発悪性黒色腫の一例 Reviewed

岡崎泰昌、松岡博美、森下由美子、秋田みどり、大原信哉、濱崎周次

日本臨床細胞学会　岡山支部会誌   Vol. 21   page： 37-38   2002

モデル動物利用マニュアルseries　疾患モデルの作成と利用　がん　中皮腫

編集　中村卓郎（ Role： Contributor）

エル・アイ・シー  2012.10  （ ISBN:978-4-900487-52-9 ）

モデル動物利用マニュアルseries　疾患モデルの作成と利用　がん　腎癌誘発モデル

編集　中村卓郎（ Role： Contributor）

エル・アイ・シー  2012.10  （ ISBN:978-4-900487-52-9 ）

慢性肝疾患における鉄毒性と除鉄治療～C型慢性肝炎を中心に～　

編集　日本鉄バイオサイエンス学会　（ Role： Contributor）

医薬ジャーナル社  2012.9  （ ISBN:978-4-7532-2567-5 ）

ロビンス　基礎病理学　原書８版　第17章　膵臓

監訳　豊國伸哉、高橋雅英（ Role： Joint translator）

丸善出版  2011.9  （ ISBN:978-4-621-08425-0 ）

血液フロンティア・鉄による発がん

企画　川端浩（ Role： Contributor）

医薬ジャーナル社  2011.5 

series モデル動物利用マニュアル疾患モデルの作成と利用　循環器疾患

編集　北徹　堀内久徳　柳田素子　猪原匡史　冨本秀和　並河徹（ Role： Joint author）

株式会社　エル・アイ・シー  2010.8  （ ISBN:978-4-900487-47-5 ）

DAP (DMT1 Associated Protein) regulates cell proliferation through the regulation of DMT1 (IRE) International conference

Okazaki Y, Nagai H, Funahashi S, Chew SH, Yeh M, Yeh KY, Glass J, Toyokuni S.

6th Biennial Meeting of SFRR (Society for Free Radical Research) Asia 

Detection and functional analyses of microRNA in high-grade phenotype of iron saccharate-induced mesothelioma in rats International conference

5th Biennial Meeting of SFRR (Society for Free Radical Research) Asia 

Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma International conference

Yasumasa Okazaki, Quan Hu, Shinya Akatsuka, Hiroki Ohara, Hirotaka Nagai, Takashi Takahashi, and Shinya Toyokuni

Society for Free Radical Research (SFRR) International XV biennial meeting 

Absence of Spred-2 enhances innate immunity during septic peritonitis. International conference

The 9th world congress on inflammation (in Tokyo) 2009. July 

DMT1 expression is regulated by DMT1 Associated Protein (DAP) in K562 cells. International conference

The 49th American Society of Hematology meeting (in Atlanta, U.S.A.) 2007.December 

A fluorescent metal sensor study providing evidence for iron transport in intestinal epithelial cells by transcytosis. International conference

2nd congress of BioIron society (in Kyoto) 2007.April 

I. Protoporphyrin IX down-regulates DMT1 Associated Protein (DAP) in K562 cells. II. DMT1 expression is regulated by DMT1 Associated Protein (DAP) in K562 cells. International conference

2nd congress of BioIron society (in Kyoto) 2007.April 2nd congress of BioIron society (in Kyoto). 

Protoporphyrin IX down-regulates DMT1 Associated Protein (DAP) in K562 cells. International conference

The 48th American Society of Hematology meeting (in Orlando, U.S.A.) 2006.December 

赤白血病細胞株(K562)におけるDAP (DMT1 Associated Protein)のシグナル伝達機構の解析

2012.4 - 2013.3

北村記念血液疾患研究基金 

ラット腹膜中皮腫において、高悪性度肉腫型中皮腫を誘発するシグナル伝達機構の解析

2012.4 - 2013.3

日比野基金　医学研究助成 

繊維性無機物質の発がん評価法の開発

2011.4 - 2012.3

日本化学工業協会　長期自主研究 

Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma

2010.10

組織的な若手研究者等海外派遣プログラム 

動物悪性中皮腫モデルの発癌過程におけるmicroRNA の役割

2009.9 - 2010.3

名古屋大学　学術振興基金 

腎臓障害、腎嚢胞の発生と腎癌の誘導に対する抗酸化剤の有効性に関する研究

2005.4 - 2006.4

企業からの受託研究 

岡山県産黒豆エキス含有のクエン酸飲料と乳清飲料の開発

2003.3 - 2004.3

バイオアクティブ岡山（岡山県庁） 

in vivoおよび in vitro の系を使っての黒豆抽出物の抗酸化作用の研究

2002.4 - 2003.3

バイオアクティブ岡山（岡山県庁） 

[研究室配属]

2011