Updated on 2021/04/01

写真a

 
SHIBATA, Hideki
 
Organization
Graduate School of Bioagricultural Sciences Associate professor
Graduate School
Graduate School of Bioagricultural Sciences
Undergraduate School
School of Agricultural Sciences
Title
Associate professor
Contact information
メールアドレス

Degree 2

  1. 博士(理学) ( 2001.9   神戸大学 ) 

  2. Master of Science

Research Interests 1

  1. calcium-binding proteins, membrane traffic

Research Areas 5

  1. Life Science / Applied biochemistry

  2. Life Science / Applied molecular and cellular biology

  3. Life Science / Functional biochemistry  / Functional Biochemistry

  4. Life Science / Cell biology

  5. Life Science / Molecular biology

Current Research Project and SDGs 2

  1. Functional analysis of calcium binding protein, ALG-2

  2. コラーゲン分泌を調節するカルシウム制御ネットワークの解析

Research History 3

  1. 名古屋大学大学院生命農学研究科 助教

    2007.4 - 2010.11

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    Country:Japan

  2. 名古屋大学大学院生命農学研究科 助手

    2000.7 - 2007.3

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    Country:Japan

  3. 神戸大学理学部 助手

    1999.2 - 2000.6

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    Country:Japan

Education 3

  1. Kobe University   Graduate School, Division of National Science and Technology

    1997.4 - 1999.1

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    Country: Japan

  2. Kobe University   Graduate School, Division of National Science and Technology   Biology

    - 1997.3

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    Country: Japan

  3. Kobe University   Faculty of Science   Department of Biology

    - 1995

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    Country: Japan

Professional Memberships 4

  1. Japan Society for Bioscience, Biotechnology, and Agrochemistry

  2. The Japanese Biochemical Society

  3. 日本細胞生物学会

  4. The Molecular Biology Society of Japan

Awards 1

  1. 農芸化学奨励賞

    2011.5   日本農芸化学会  

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    Country:Japan

 

Papers 77

  1. The Novel ALG-2 Target Protein CDIP1 Promotes Cell Death by Interacting with ESCRT-I and VAPA/B. Reviewed

    Inukai R, Mori K, Kuwata K, Suzuki C, Maki M, Takahara T, Shibata H

    International journal of molecular sciences   Vol. 22 ( 3 )   2021.1

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms22031175

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  2. The Penta-EF-Hand ALG-2 Protein Interacts with the Cytosolic Domain of the SOCE Regulator SARAF and Interferes with Ubiquitination Reviewed

    Zhang Wei, Muramatsu Ayaka, Matsuo Rina, Teranishi Naoki, Kahara Yui, Takahara Terunao, Shibata Hideki, Maki Masatoshi

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 21 ( 17 )   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms21176315

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  3. Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes Invited Reviewed

      Vol. 27 ( 1 ) page: 87   2020.8

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12929-020-00679-2

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    PubMed

  4. ATeam technology for detecting early signs of viral cytopathic effect Reviewed

      Vol. 82 ( 3 ) page: 387 - 393   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1292/jvms.20-0021

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  5. SH3YL1 cooperates with ESCRT-I in the sorting and degradation of the EGF receptor Reviewed

      Vol. 132 ( 19 )   2019.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1242/jcs.229179

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  6. Adaptor functions of the Ca<sup>2+</sup>-binding protein ALG-2 in protein transport from the endoplasmic reticulum.

    Shibata H

    Bioscience, biotechnology, and biochemistry   Vol. 83 ( 1 ) page: 20-32   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/09168451.2018.1525274

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  7. Cellular Ca<sup>2+</sup>-Responding Nanoluciferase Reporter Gene System Directed by Tandemly Repeated Pseudo-palindromic NFAT-Response Elements.

    Zhang W, Takahara T, Achiha T, Shibata H, Maki M

    Methods in molecular biology (Clifton, N.J.)   Vol. 1929   page: 95-109   2019

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    DOI: 10.1007/978-1-4939-9030-6_7

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  8. High Sensitive Quantitative Binding Assays Using a Nanoluciferase-Fused Probe for Analysis of ALG-2-Interacting Proteins.

    Zhang W, Matsuo R, Takahara T, Shibata H, Maki M

    Methods in molecular biology (Clifton, N.J.)   Vol. 1929   page: 501-516   2019

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    DOI: 10.1007/978-1-4939-9030-6_31

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  9. A microtubule-associated protein MAP1B binds to and regulates localization of a calcium-binding protein ALG-2

    Takahara Terunao, Arai Yumika, Kono Yuta, Shibata Hideki, Maki Masatoshi

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 497 ( 2 ) page: 492-498   2018.3

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    DOI: 10.1016/j.bbrc.2018.02.048

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  10. Nanoluciferase Reporter Gene System Directed by Tandemly Repeated Pseudo-Palindromic NFAT-Response Elements Facilitates Analysis of Biological Endpoint Effects of Cellular Ca2+ Mobilization

    Zhang Wei, Takahara Terunao, Achiha Takuya, Shibata Hideki, Maki Masatoshi

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 19 ( 2 )   2018.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms19020605

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  11. The calcium-binding protein ALG-2 regulates protein secretion and trafficking via interactions with MISSL and MAP1B proteins. Reviewed

    Terunao Takahara, Kuniko Inoue, Yumika Arai, Keiko Kuwata, Hideki Shibata, Masatoshi Maki

    Journal of Biological Chemistry   Vol. 292 ( 41 ) page: 17057-17072   2017.10

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    DOI: 10.1074/jbc.M117.800201.

  12. Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis. Reviewed

    Bradley N. Smith, Simon D. Topp, Claudia Fallini, Hideki Shibata, Han-Jou Chen, Claire Troakes, Andrew King, Nicola Ticozzi, Kevin P. Kenna, Athina Soragia-Gkazi, Jack W. Miller, Akane Sato, Diana Marques Dias, Maryangel Jeon, Caroline Vance, Chun Hao Wong, Martina de Majo, Wejdan Kattuah, Jacqueline C. Mitchell, Emma L. Scotter, Nicholas W. Parkin, Peter C. Sapp, Matthew Nolan, Peter J. Nestor, Michael Simpson, Michael Weale, Monkel Lek, Frank Baas, J. M. Vianney de Jong, Anneloor L. M. A. ten Asbroek, Alberto Garcia Redondo, Jesús Esteban-Pérez, Cinzia Tiloca, Federico Verde, Stefano Duga, Nigel Leigh, Hardev Pall, Karen E. Morrison, Ammar Al-Chalabi, Pamela J. Shaw, Janine Kirby, Martin R. Turner, Kevin Talbot, Orla Hardiman, Jonathan D. Glass, Jacqueline De Belleroche, Masatoshi Maki, Stephen E. Moss, Christopher Miller, Cinzia Gellera, Antonia Ratti, Safa Al-Sarraj, Robert H. Brown Jr., Vincenzo Silani, John E. Landers, Christopher E. Shaw

    Science Translational Medicine   Vol. 9 ( 388 ) page: eaad9157   2017.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/scitranslmed.aad9157

  13. The calcium-binding protein ALG-2 promotes endoplasmic reticulum exit site localization and polymerization of Trk-fused gene (TFG) protein. Reviewed

    Takashi Kanadome, Hideki Shibata, Keiko Kuwata, Terunao Takahara, Masatoshi Maki

    The FEBS Journal   Vol. 284 ( 1 ) page: 56-76   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/febs.13949

  14. Multifaceted Roles of ALG-2 in Ca2+-Regulated Membrane Trafficking. Reviewed

    Masatoshi Maki, Terunao Takahara, Hideki Shibata

    International Journal of Molecular Sciences   Vol. 17 ( 9 ) page: E1401   2016.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms17091401.

  15. Tubby-like protein superfamily member PLSCR3 functions as a negative regulator of adipogenesis in mouse 3T3-L1 preadipocytes by suppressing induction of late differentiation stage transcription factors. Reviewed

    Akira Inokawa, Tatsutoshi Inuzuka, Terunao Takahara, Hideki Shibata, Masatoshi Maki

    Bioscience Reports   Vol. 36 ( 1 ) page: e00287   2016.1

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    DOI: 10.1042/BSR20150215

  16. A New Role for Annexin A11 in the Early Secretory Pathway via Stabilizing Sec31A Protein at the Endoplasmic Reticulum Exit Sites (ERES). Reviewed

    Hideki Shibata, Takashi Kanadome, Hirofumi Sugiura, Takeru Yokoyama, Minami Yamamuro, Stephen E. Moss, Masatoshi Maki

    The Journal of Biological Chemistry   Vol. 290 ( 8 ) page: 4981-4993   2015.2

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    DOI: 10.1074/jbc.M114.592089

  17. Structural Analysis of the Complex between Penta-EF-Hand ALG-2 Protein and Sec31A Peptide Reveals a Novel Target Recognition Mechanism of ALG-2 Reviewed

    Takeshi Takahashi, Kyosuke Kojima, Wei Zhang, Kanae Sasaki, Masaru Ito, Hironori Suzuki, Masato Kawasaki, Soichi Wakatsuki, Terunao Takahara, Hideki Shibata, Masatoshi Maki

    International Journal of Molecular Sciences   Vol. 16 ( 2 ) page: 3677-3699   2015.2

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    DOI: 10.3390/ijms16023677

  18. Involvement of calpain-7 in epidermal growth factor receptor degradation via the endosomal sorting pathway. Reviewed

    Yuki Maemoto, Yasuko Ono, Satomi Kiso, Hideki Shibata, Terunao Takahara, Hiroyuki Sorimachi, Masatoshi Maki

    FEBS J.   Vol. 281 ( 16 ) page: 3642-3655   2014.7

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  19. Nuclear ALG-2 protein interacts with Ca2+ homeostasis endoplasmic reticulum protein (CHERP) Ca2+-dependently and participates in regulation of alternative splicing of inositol trisphosphate receptor type 1 (IP3R1) pre-mRNA. Reviewed

    Kanae Sasaki-Osugi, Chiaki Imoto, Terunao Takahara, Hideki Shibata, Masatoshi Maki

    J. Biol. Chem.   Vol. 288 ( 46 ) page: 33361-33375   2013.9

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  20. VPS37 isoforms differentially modulate the ternary complex formation of ALIX, ALG-2, and ESCRT-I. Reviewed

    Mayumi Okumura, Angela M. Katsuyama, Hideki Shibata, Masatoshi Maki

    Biosci. Biotechnol. Biochem.   Vol. 77 ( 8 ) page: 1715-1721   2013.8

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  21. Identification of phosphorylation sites in the C-terminal region of charged multivesicular body protein 1A (CHMP1A). Reviewed

    Yuki Maemoto, Hideki Shibata, Masatoshi Maki

    Biosci. Biotechnol. Biochem.   Vol. 77 ( 6 ) page: 1317-1319   2013.6

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  22. Mammalian ESCRT-III-related protein IST1 has a distinctive Met-Pro repeat sequence that is essential for interaction with ALG-2 in the presence of Ca2+. Reviewed

    Mayumi Okumura, Takeshi Takahashi, Hideki Shibata, Masatoshi Maki

    Biosci. Biotechnol. Biochem.   Vol. 77 ( 5 ) page: 1049-1054   2013.5

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  23. Analysis of limited proteolytic activity of calpain-7 using non-physiological substrates in mammalian cells. Reviewed

    Yuki Maemoto, Satomi Kiso, Hideki Shibata, Masatoshi Maki

    FEBS J.   Vol. 280 ( 11 ) page: 2594-2607   2013.4

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  24. ALG-2-interacting Tubby-like protein superfamily member PLSCR3 is secreted by an exosomal pathway and taken up by recipient cultured cells. Reviewed

    Tatsutoshi Inuzuka, Akira Inokawa, Cen Chen, Kumiko Kizu, Hiroshi Narita, Hideki Shibata, Masatoshi Maki

    Biosci. Rep.   Vol. 33 ( 2 ) page: e00026   2013.3

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  25. Biochemical and immunological detection of physical interactions between penta-EF-hand protein ALG-2 and its binding partners. Reviewed

    Kanae Osugi, Hideki Shibata, Masatoshi Maki

    Methods Mol Biol.   Vol. 963   page: 187-200   2012.11

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    DOI: 10.1007/978-1-62703-230-8_12.

  26. Prediction of a New Ligand-Binding Site for Type 2 Motif based on the Crystal Structure of ALG-2 by Dry and Wet Approaches. Reviewed

    Takeshi Takahashi, Hironori Suzuki, Tatsutoshi Inuzuka, Hideki Shibata, Masatoshi Maki

    Int J Mol Sci.   Vol. 13 ( 6 ) page: 7535-7549   2012.6

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  27. Identification of the P-body component PATL1 as a novel ALG-2-interacting protein by in silico and far-Western screening of proline-rich proteins. Reviewed

    Kanae Osugi, Hironori Suzuki, Tomomi Nomura, Yasuo Ariumi, Hideki Shibata, Masatoshi Maki

    J Biochem.   Vol. 151 ( 6 ) page: 657-666   2012.6

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  28. Evolutionary and physical linkage between calpains and penta-EF-hand Ca2+-binding proteins. Reviewed

    Masatoshi Maki, Yuki Maemoto, Yohei Osako, Hideki Shibata

    FEBS J.   Vol. 279 ( 8 ) page: 1414-1421   2012.4

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    DOI: 10.1111/j.1742-4658.2012.08560.x.

  29. Calpain-7 binds to CHMP1B at its second α-helical region and forms a ternary complex with IST1. Reviewed

    Yuki Maemoto, Yohei Osako, Emi Goto, Eri Nozawa, Hideki Shibata, Masatoshi Maki

    J. Biochem.   Vol. 150 ( 4 ) page: 411-421   2011.10

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  30. Structure and function of ALG-2, a penta-EF-hand calcium-dependent adaptor protein. Reviewed

    Masatoshi Maki, Hironori Suzuki, Hideki Shibata

    Sci China Life Sci.   Vol. 54 ( 8 ) page: 770-779   2011.8

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  31. Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interaction. Reviewed

    Yohei Osako, Yuki Maemoto, Ryohei Tanaka, Hironori Suzuki, Hideki Shibata, Masatoshi Maki

    FEBS J.   Vol. 277 ( 21 ) page: 4412-4426   2010.11

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  32. *The ALG-2 binding site in Sec31A influences the retention kinetics of Sec31A at the endoplasmic reticulum exit sites as revealed by live-cell time-lapse imaging. Reviewed

    Shibata H, Inuzuka T, Yoshida H, Sugiura H, Wada I, Maki M.

    Biosci Biotechnol Biochem.   Vol. 74 ( 9 ) page: 1819-1826   2010.9

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    ALG-2, a member of the penta-EF-hand protein family, interacts Ca²+-dependently with a COPII component, Sec31A. In this study, we first established HeLa cells stably expressing green fluorescent protein-fused ALG-2 (GFP-ALG-2) and red fluorescent protein-fused Sec31A (Sec31A-RFP). After inducing Ca²+-mobilization, the cytoplasmic distribution of GFP-ALG-2 changed from a diffuse to a punctate pattern, which extensively overlapped with the Sec31A-RFP-positive structures, indicating that ALG-2 is recruited to the endoplasmic reticulum exit sites (ERES) in living cells. Next, overlay experiments with biotin-labeled ALG-2 were done to dissect the ALG-2 binding site (ABS). They revealed that a sequence comprising amino acid residues 839-851 in the Pro-rich region was necessary and sufficient for direct binding to ALG-2. Finally, fluorescence recovery after photobleaching analysis indicated that the ABS deletion reduced the high-affinity population of Sec31A to the ERES, suggesting that the ABS is one of the key determinants of the retention kinetics of Sec31A at ERES.

  33. Distinct functions of human MVB12A and MVB12B in the ESCRT-I dependent on their posttranslational modifications. Reviewed

    Takumi Tsunematsu, Emiko Yamauchi, Hideki Shibata, Masatoshi Maki, Takeshi Ohta, Hiroaki Konishi

    Biochem. Biophys. Res. Commun.   Vol. 399 ( 2 ) page: 232-237   2010.8

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  34. Molecular basis for defect in Alix-binding by alternatively spliced isoform of ALG-2 (ALG-2DeltaGF122) and structural roles of F122 in target recognition. Reviewed

    Tatsutoshi Inuzuka, Hironori Suzuki, Masato Kawasaki, Hideki Shibata, Soichi Wakatsuki, Masatoshi Maki

    BMC Struct. Biol.   Vol. 10   2010.8

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    DOI: doi:10.1186/1472-6807-10-25

  35. *Penta-EF-hand protein ALG-2 functions as a Ca2+-dependent adaptor that bridges Alix and TSG101. Reviewed

    Okumura M, Ichioka F, Kobayashi R, Suzuki H, Yoshida H, Shibata H, Maki M.

    Biochem Biophys Res Commun.   Vol. 386 ( 1 ) page: 237-241   2009.8

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  36. The mechanism of Ca2+-dependent recognition of Alix by ALG-2: insights from X-ray crystal structures. Reviewed

    Suzuki H, Kawasaki M, Inuzuka T, Okumura M, Kakiuchi T, Shibata H, Wakatsuki S, Maki M.

    Biochem Soc Trans.   Vol. 37 ( Pt1 ) page: 190-194   2009.2

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  37. Crystallization and X-ray diffraction analysis of N-terminally truncated human ALG-2. Reviewed

    Hironori Suzuki, Masato Kawasaki, Tatsutoshi Inuzuka, Mayumi Okumura, Takeshi Kakiuchi, Hideki Shibata, Soichi Wakatsuki, Masatoshi Maki

    Acta Crystallogr Sect F Struct Biol Cryst Commun.   Vol. 64 ( Pt11 ) page: 974-977   2008.11

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  38. *Structural basis for Ca2+-dependent formation of ALG-2/Alix peptide complex: Ca2+/EF3-driven arginine switch mechanism. Reviewed

    Hironori Suzuki, Masato Kawasaki, Tatsutoshi Inuzuka, Mayumi Okumura, Takeshi Kakiuchi, Hideki Shibata, Soichi Wakatsuki, Masatoshi Maki

    Structure   Vol. 16 ( 10 ) page: 1562-1573   2008.10

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  39. *Human calpain7/PalBH associates with a subset of ESCRT-III-related proteins in its N-terminal region and partly localizes to endocytic membrane compartments. Reviewed

    Chiharu Yorikawa, Emi Takaya, Yohei Osako, Ryohei Tanaka, Yoshinori Terasawa, Takao Hamakubo, Yasuhiro Mochizuki, Hiroko Iwanari, Tatsuhiko Kodama, Tatsuya Maeda, Kiyotaka Hitomi, Hideki Shibata, Masatoshi Maki

    J. Biochem.   Vol. 143 ( 6 ) page: 731-745   2008.6

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  40. *Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants. Reviewed

    Hideki Shibata, Hironori Suzuki, Takeshi Kakiuchi, Tatsutoshi Inuzuka, Haruna Yoshida, Takako Mizuno, Masatoshi Maki

    J. Biol. Chem.   Vol. 283 ( 15 ) page: 9623-9632   2008.4

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  41. Brox, a novel farnesylated Bro1 domain-containing protein that associates with charged multivesicular body protein 4 (CHMP4). Reviewed

    Fumitaka Ichioka, Ryota Kobayashi, Keiichi Katoh, Hideki Shibata, Masatoshi Maki

    FEBS J.   Vol. 275 ( 4 ) page: 682-692   2008.2

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  42. Identification of substrates for transglutaminase in Physarum polycephalum, an acellular slime mold, upon cellular mechanical damage. Reviewed

    Fumitaka Wada, Hiroki Hasegawa, Akio Nakamura, Yoshiaki Sugimura, Yoshiki Kawai, Narie Sasaki, Hideki Shibata, Masatoshi Maki, Kiyotaka Hitomi

    FEBS J.   Vol. 274 ( 11 ) page: 2766-2777   2007.4

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  43. *ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner. Reviewed

    Hideki Shibata, Hironori Suzuki, Haruna Yoshida, Masatoshi Maki

    Biochem. Biophys. Res. Commun.   Vol. 353 ( 3 ) page: 756-763   2007.2

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  44. HD-PTP and Alix share some membrane-traffic related proteins that interact with their Bro1 domains or proline-rich regions. Reviewed

    Fumitaka Ichioka, Emi Takaya, Hironori Suzuki, Sachiko Kajigaya, Vladimir L. Buchman, Hideki Shibata, Masatoshi Maki

    Arch. Biochem. Biophys.   Vol. 457 ( 2 ) page: 142-149   2007.1

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  45. The penta-EF-hand protein ALG-2 and its interacting proteins. Reviewed

    Masatoshi Maki, Hideki Shibata

    Calcium Binding Proteins   Vol. 2   page: 4-10   2007

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  46. CHMP7, a novel ESCRT-III-related protein, associates with CHMP4b and functions in the endosomal sorting pathway. Reviewed

    Mio Horii, Hideki Shibata, Ryota Kobayashi, Keiichi Katoh, Chiharu Yorikawa, Jiro Yasuda, Masatoshi Maki

    Biochem. J.   Vol. 400 ( 1 ) page: 23-32   2006.11

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  47. Reevaluation of the Predicted Gene Structure of Dictyostelium Cyctatin A3 (cpiC) by Nucleotide Sequence Determination of its cDNA and its Phylogenetic Position in the Cyctatin Superfamily Reviewed

    Medhat S. El-Halawany, Hideki Shibata, Kiyotaka Hitomi, Masatoshi Maki

    Molecular Biology Reports   Vol. 32 ( 4 ) page: 257-264   2005.12

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  48. The penta-EF-hand protein ALG-2 interacts directly with the ESCRT-I component TSG101, and Ca2+-dependently co-localizes to aberrant endosomes with dominant-negative AAA ATPase SKD1/Vps4B Reviewed

    Keiichi Katoh, Hidenori Suzuki, Yoshinori Terasawa, Takako Mizuno, Jiro Yasuda, Hideki Shibata, Masatoshi Maki

    Biochemical Journal   Vol. 391 ( Pt 3 ) page: 677-685   2005.11

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  49. Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting Reviewed

    Chiharu Yorikawa, Hideki Shibata, Satoshi Waguri, Kazumi Hatta, Mio Horii, Keiichi Katoh, Toshihide Kobayashi, Yasuo Uchiyama, Masatoshi Maki

    Biochemical Journal   Vol. 387 ( Pt 1 ) page: 17-26   2005.4

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  50. Identification of Rab GTPase-Activating Protein-Like Protein (RabGAPLP) as a Novel Alix/AIP1-Interacting Protein Reviewed

    Fumitaka Ichioka, Mio Horii, Keiichi Katoh, Yoshinori Terasawa, Hideki Shibata, Masatoshi Maki

    Bioscience, Biotechnology, and Biochemistry   Vol. 69 ( 4 ) page: 861-865   2005.4

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  51. Dictyostelium discoideum requires an Alix/AIP1 homolog, DdAlix, for morphogenesis in alkaline environments Reviewed

    Susumu Ohkouchi, Hajime Saito, Fumika Aruga, Tatsuya Maeda, Hideki Shibata, Masatoshi Maki

    FEBS Letters   Vol. 579 ( 7 ) page: 1745-1750   2005.3

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  52. DdAlix, an Alix/AIP1 homolog in Dictyostelium discoideum, is required for multicellular development under low Ca2+ conditions Reviewed

    Susumu Ohkouchi, Medhat S. El-Halawany, Fumika Aruga, Hideki Shibata, Kiyotaka Hitomi, Masatoshi Maki

    Gene   Vol. 337   page: 131-139   2004.8

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  53. Identification of cysteine protease inhibitors that belong to cystatin family 1 in the cellular slime mold Dictyostelium discoideum Reviewed

    Medhat S. El-Halawany, Susumu Ohkouchi, Hideki Shibata, Kiyotaka Hitomi, Masatoshi Maki

    Biological Chemistry   Vol. 385 ( 6 ) page: 547-550   2004.6

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  54. Protein kinase PKN1 associates with TRAF2 and is involved in TRAF2-NF-kappaB signaling pathway Reviewed

    Yusuke Gotoh, Kumiko Oishi, Hideki Shibata, Akiko Yamagiwa, Takayuki Isagawa, Tamako Nishimura, Emiko Goyama, Mikiko Takahashi, Hideyuki Mukai, Yoshitaka Ono

    Biochemical and Biophysical Research Communications   Vol. 314 ( 3 ) page: 688-694   2004.2

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  55. The Penta-EF-Hand Protein ALG-2 Interacts with a Region Containing PxY Repeats in Alix/AIP1, Which Is Required for the Subcellular Punctate Distribution of the Amino-Terminal Truncation Form of Alix/AIP1 Reviewed

    Hideki Shibata, Keiko Yamada, Takako Mizuno, Chiharu Yorikawa, Hiroshi Takahashi, Hirokazu Satoh, Yasuyuki Kitaura, Masatoshi Maki

    The Journal of Biochemistry   Vol. 135 ( 1 ) page: 117-128   2004.1

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  56. CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms Reviewed

    Keiichi Katoh, Hideki Shibata, Kazumi Hatta, Masatoshi Maki

    Archives of Biochemistry and Biophysics   Vol. 421 ( 1 ) page: 159-165   2004.1

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  57. The ALG-2-interacting Protein Alix Associates with CHMP4b, a Human Homologue of Yeast Snf7 That Is Involved in Multivesicular Body Sorting Reviewed

    Keiichi Katoh, Hideki Shibata, Hidenori Suzuki, Atsuki Nara, Kazumi Ishidoh, Eiki Kominami, Tamotsu Yoshimori, Masatoshi Maki

    The Journal of Biological Chemistry   Vol. 278 ( 40 ) page: 39104-39113   2003.10

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    Language:English   Publishing type:Research paper (scientific journal)  

  58. The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner Reviewed

    Hirokazu Satoh, Yoshimi Nakano, Hideki Shibata, Masatoshi Maki

    Biochimica et Biophysica Acta   Vol. 1600 ( 1-2 ) page: 61-67   2002.11

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    Language:English   Publishing type:Research paper (scientific journal)  

  59. Structures, functions and molecular evolution of the penta-EF-hand Ca2+-binding proteins Reviewed

      Vol. 1600 ( 1-2 ) page: 51-60   2002.11

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  60. ALG-2 Interacts with the Amino-Terminal Domain of Annexin XI in a Ca2+-Dependent Manner Reviewed

    Hirokazu Satoh, Hideki Shibata, Yoshimi Nakano, Yasuyuki Kitaura, Masatoshi Maki

    Biochemical and Biophysical Research Communications   Vol. 291 ( 5 ) page: 1166-1172   2002.3

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    Language:English   Publishing type:Research paper (scientific journal)  

  61. Both ALG-2 and Peflin, Penta-EF-hand (PEF) Proteins, Are Stabilized by Dimerization through Their Fifth EF-Hand Regions Reviewed

    Yasuyuki Kitaura, Hirokazu Satoh, Hiroshi Takahashi, Hideki Shibata, Masatoshi Maki

    Archives of Biochemistry and Biophysics   Vol. 399 ( 1 ) page: 12-18   2002.3

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  62. PKNbeta Interacts with the SH3 Domains of Graf and a Novel Graf Related Protein, Graf2, Which Are GTPase Activating Proteins for Rho Family Reviewed

    Hideki Shibata, Kumiko Oishi, Akiko Yamagiwa, Mikiko Matsumoto, Hideyuki Mukai, Yoshitaka Ono

    The Journal of Biochemistry   Vol. 130 ( 1 ) page: 23-31   2001.7

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  63. Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2 Reviewed

    Hideki Shibata, Hisanobu Oda, Hideyuki Mukai, Kumiko Oishi, Kazuyo Misaki, Hiroaki Ohkubo, Yoshitaka Ono

    Brain Reserch Molecular Brain Reserch   Vol. 74 ( 1-2 ) page: 126-134   1999.12

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  64. Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha Reviewed

    Kumiko Oishi, Hideyuki Mukai, Hideki Shibata, Mikiko Takahashi, Yoshitaka Ono

    Biochemical and Biophysical Research Communications   Vol. 261 ( 3 ) page: 808-814   1999.8

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  65. Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus Reviewed

    Mikiko Takahashi, Hideki Shibata, Masaki Shimakawa, Masaaki Miyamoto, Hideyuki Mukai, Yoshitaka Ono

    The Journal of Biological Chemistry   Vol. 274 ( 24 ) page: 17267-17274   1999.6

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  66. Interaction of the small G protein RhoA with the C terminus of human phospholipase D1 Reviewed

    "Masakazu Yamazaki, Yue Zhang, Hiroshi Watanabe, Takeaki Yokozeki, Shigeo Ohno, Kozo Kaibuchi, Hideki Shibata, Hideyuki Mukai, Yoshitaka Ono, Michael A. Frohman, Yasunori Kanaho"

    The Journal of Biological Chemistry   Vol. 274 ( 10 ) page: 6035-6038   1999.3

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  67. PKN interacts with a paraneoplastic cerebellar degeneration-associated antigen, which is a potential transcription factor Reviewed

    Hiromi Takanaga, Hideyuki Mukai, Hideki Shibata, Masanao Toshimori, Yoshitaka Ono

    Experimental Cell Research   Vol. 241 ( 2 ) page: 363-372   1998.6

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  68. Domain-specific phosphorylation of vimentin and glial fibrillary acidic protein by PKN Reviewed

    Kaori Matsuzawa, Hidetaka Kosako, Naoyuki Inagaki, Hideki Shibata, Hideyuki Mukai, Yoshitaka Ono, Mutsuki Amano, Kozo Kaibuchi, Yoshiharu Matsuura, Ichiro Azuma, Masaki Inagaki

    Biochemical and Biophysical Research Communications   Vol. 234 ( 3 ) page: 621-625   1997.5

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  69. Interaction of PKN with alpha-actinin Reviewed

    Hideyuki Mukai, Masanao Toshimori, Hideki Shibata, Hiromi Takanaga, Michinori Kitagawa, Masako Miyahara, Masaki Shimakawa, Yoshitaka Ono

    The Journal of Biological Chemistry   Vol. 272 ( 8 ) page: 4740-4746   1997.2

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  70. Translocation of PKN from the cytosol to the nucleus induced by stresses Reviewed

    Hideyuki Mukai, Masako Miyahara, Hiroko Sunakawa, Hideki Shibata, Masanao Toshimori, Michinori Kitagawa, Masaki Shimakawa, Hiromi Takanaga, Yoshitaka Ono

    Proceedings of the National Academy of Sciences of the United States of America   Vol. 93 ( 19 ) page: 10195-10199   1996.9

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  71. Characterization of the interaction between RhoA and the amino-terminal region of PKN. Reviewed

    Hideki Shibata, Hideyuki Mukai,Yoshimasa Inagaki, Yoshimi Homma, Kazushi Kimura, Kozo Kaibuchi, Shuh Narumiya, Yoshitaka Ono

    FEBS Letters   Vol. 385 ( 3 ) page: 221-224   1996.5

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  72. PKN associates and phosphorylates the head-rod domain of neurofilament protein Reviewed

    Hideyuki Mukai, Masanao Toshimori, Hideki Shibata, Michinori Kitagawa, Masaki Shimakawa, Masako Miyahara, Hiroko Sunakawa, Yoshitaka Ono

    The Journal of Biological Chemistry   Vol. 271 ( 16 ) page: 9816-9822   1996.4

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  73. The role of the unique motifs in the amino-terminal region of PKN on its enzymatic activity Reviewed

    Michinori Kitagawa, Hideki Shibata, Masanao Toshimori, Hideyuki Mukai, Yoshitaka Ono

    Biochemical and Biophysical Research Communications   Vol. 220 ( 3 ) page: 963-968   1996.3

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  74. Identification of Schizosaccharomyces pombe gene psk1+, encoding a novel putative serine/threonine protein kinase, whose mutation conferred resistance to phenylarsine oxide." Reviewed

    Hideyuki Mukai, Masako Miyahara, Hiromi Takanaga, Michinori Kitagawa, Hideki Shibata, Masaki Shimakawa, Yoshitaka Ono

    Gene   Vol. 166 ( 1 ) page: 155-159   1995.12

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  75. Purification and characterization of a fatty acid-activated protein kinase (PKN) from rat testis Reviewed

    Michinori Kitagawa, Hideyuki Mukai, Hideki Shibata, Yoshitaka Ono"

    Biochemical Journal   Vol. 310 ( Pt 2 ) page: 657-664   1995.9

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  76. Xenopus PKN: cloning and sequencing of the cDNA and identification of conserved domains Reviewed

    Hideyuki Mukai, Kazuya Mori, Hiromi Takanaga, Michinori Kitagawa, Hideki Shibata, Masaki Shimakawa, Masako Miyahara, Yoshitaka Ono"

    Biochimica et Biophysica Acta   Vol. 1261 ( 2 ) page: 296-300   1995.4

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  77. Activation of PKN, a novel 120-kDa protein kinase with leucine zipper- like sequences, by unsaturated fatty acids and by limited proteolysis Reviewed

    Biochemical and Biophysical Research Communications   Vol. 204 ( 1 ) page: 348-356   1994.10

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Books 3

  1. カルシウム依存的相互作用因子から探るpenta-EF-handファミリーの機能 Reviewed

    牧正敏,高原照直,柴田秀樹( Role: Joint author)

    日本生化学会  2019.4 

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    Total pages:191-209   Language:Japanese Book type:Scholarly book

    DOI: 10.14952/SEIKAGAKU.2019.910191

  2. 小胞体からの分子輸送におけるALG-2の役割 Reviewed

    柴田秀樹, 高原照直, 京卓志, 牧正敏( Role: Joint author)

    北隆館/ニュー・サイエンス社  2018.6 

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    Language:Japanese Book type:Scholarly book

  3. 「エンドソームでの輸送選別に働くESCRT装置」メンブレントラフィック : 膜・小胞による細胞内輸送ネットワーク(第6章) Reviewed

    柴田秀樹, 牧正敏( Role: Joint author)

    化学同人  2016.7  ( ISBN:9784759817232

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    Language:Japanese Book type:Textbook, survey, introduction

Presentations 19

  1. 損傷リソソームへのCa2+結合タンパク質ALG-2動員の分子機構解析

    川野琢己、舟橋里帆、森花菜子、桑田啓子、牧正敏、高原照直、柴田秀樹

    第43回日本分子生物学会年会  日本分子生物学会

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    Event date: 2020.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Web開催  

  2. ストア作動性カルシウム流入制御因子SARAFの二量体形成におけるALG-2の役割

    河原由衣、高原照直、柴田秀樹、牧正敏

    第187回日本農芸化学会中部支部例会  日本農芸化学会中部支部

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web開催  

  3. アミノ酸応答シグナル経路におけるカルシウムを介した新規制御機構の解明

    雨宮優奈、池田奈央、柴田秀樹、牧正敏、高原照直

    第187回日本農芸化学会中部支部例会  日本農芸化学会中部支部

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web開催  

  4. Ca2+結合タンパク質ALG-2の損傷リソソーム動員機構の解析

    川野琢己、舟橋里帆、高原照直、牧正敏、柴田秀樹

    第72回日本細胞生物学会大会  2020.6  日本細胞生物学会

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    Event date: 2020.6

    Language:Japanese  

    Venue:Web開催  

  5. 近接依存性標識法を用いた初期分泌経路制御タンパク質の探索

    伊藤駿、松下明理、桑田啓子、鄭光傑、高原照直、柴田秀樹

    第72回日本細胞生物学会大会 

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    Event date: 2020.6

    Language:Japanese  

    Venue:Web開催  

  6. カルシウム応答性NFATレポーター測定によるTRPチャネルの機能評価

    阿知波卓也,張維,高原照直,柴田秀樹,牧正敏

    日本農芸化学会2019年度大会 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京農業大学   Country:Japan  

  7. リソソーム傷害部位へのカルシウム結合タンパク質ALG-2の動員

    林本敬大, 柴田秀樹, 川野琢己, 高原照直, 牧正敏

    日本農芸化学会2019年度大会 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京農業大学   Country:Japan  

  8. アミノ酸によるmTORC1活性化の新規メカニズムの解析

    高原照直, 池田奈央, 石井千愛, 柴田秀樹, 牧正敏

    日本農芸化学会2019年度大会 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京農業大学   Country:Japan  

  9. 損傷リソソームへのアネキシンA11とALG-2の動員とその生理的役割の解析

    林本敬大, 川野琢己, 高原照直, 牧正敏, 柴田秀樹

    第4回日本アネキシン研究会年会 

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    Event date: 2018.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京大学農学部   Country:Japan  

  10. DNA傷害誘発性アポトーシスにおけるカルシウムイオン結合タンパク質ALG-2のアポトーシス促進性機能の解析

    犬飼隆太、森可奈子、高原照直、柴田秀樹、牧正敏

    第41回日本分子生物学会年会 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:パシフィコ横浜   Country:Japan  

  11. SARAFのユビキチン修飾におけるALG-2の役割とPPxY配列の関与

    村松彩夏, 張維, 寺西直樹, 河原由衣, 髙原照直, 柴田秀樹, 牧正敏

    第41回日本分子生物学会年会 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:パシフィコ横浜   Country:Japan  

  12. SARAFとNedd4 ファミリーE3ユビキチンリガーゼとの相互作用解析

    寺西直樹, 村松彩夏, 張維, 髙原照直, 柴田秀樹, 牧正敏

    第41回日本分子生物学会年会 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  13. アミノ酸によるmTORC1活性調節におけるカルシウムシグナルの役割の解析

    池田奈央, 石井千愛, 渡邊穂実, 王悦, 中村奈央, 高原照直, 柴田秀樹, 牧正敏

    第41回日本分子生物学会年会 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  14. 微小管結合タンパク質MAP1Bを介したアポトーシス誘導経路の解析

    河野雄太、新居裕美香、高原照直、柴田秀樹、牧正敏

    第41回日本分子生物学会年会 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  15. 近接ラベリング手法を用いたコラーゲン分泌制御因子の網羅的探索

    松下明理,柴田秀樹,桑田啓子, 高原照直,牧正敏

    日本農芸化学会第183回中部支部例会 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  16. The penta-EF-hand ALG-2 protein interacts with the SOCE regulator SARAF and interferes with ubiquitylation International conference

    Masatoshi Maki, Wei Zhang, Ayaka Muramatsu, Naoki Teranishi, Rio Matsuo, Terunao Takahara, Hideki Shibata

    European Calcium Society 2018 

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    Event date: 2018.9

    Language:English   Presentation type:Poster presentation  

    Venue:Hamburg, Germany   Country:Germany  

  17. Adaptor function of a calcium-binding protein ALG-2 in doxorubicin-induced apoptosis

    Kanako Mori, Ryuta Inukai, Terunao Takahara, Masatoshi, Maki, Hideki Shibata

    Joint Annual Meeting of JSCB 51st and JSCB 70th 

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    Event date: 2018.6

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  18. 小胞体からのタンパク質の搬出におけるカルシウム結合タンパク質の生理的役割

    京卓志、横山健、山室南、三宅博、牧正敏、柴田秀樹

    日本農芸化学会中部支部 第165回例会 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  19. The penta-EF-hand protein ALG-2 stabilises a COPII component Sec31A at ER exit sites by recruiting Annexin A11 International conference

    Hideki Shibata, Takashi Kanadome, Minami Yamamuro, Stephen E. Moss, Masatoshi Maki

    12th symposium of the European Calcium Society 

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    Event date: 2012.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:France  

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Research Project for Joint Research, Competitive Funding, etc. 4

  1. 線維性コラーゲンの分泌機構の解明とその制御を目指す基礎研究

    2021.2

    公益財団法人 小柳財団  2021年度研究助成 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\1000000

  2. カルシウム依存性ユビキチン化修飾を介するコラーゲン分泌調節機構に関する研究

    2018.4

    堀科学芸術振興財団 

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    Authorship:Principal investigator  Grant type:Competitive

  3. カルシウム振動による物質輸送制御機構の解析

    2011.11 - 2013.10

    豊秋奨学会 研究費助成 

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    Authorship:Principal investigator  Grant type:Competitive

  4. カルシウム振動のシグナル変換機構の解明

    2009

    上原記念生命科学財団 

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    Authorship:Principal investigator  Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. 神経変性過程の抑制を標的としたエンドソーム経路の機能改変

    2019.6

    科学研究費補助金  挑戦的研究(萌芽)

    柴田 秀樹

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\6240000 ( Direct Cost: \4800000 、 Indirect Cost:\1440000 )

  2. コラーゲン分泌を調節するカルシウム制御ネットワークの解析

    2018.4

    科学研究費補助金  基盤研究(B)

    柴田 秀樹

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    Authorship:Principal investigator 

  3. 小胞体から出芽する輸送小胞の形成調節機構の解明と応用

    2015.4 - 2018.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  4. 初期分泌経路におけるカルシウム振動シグナル変換機構の解析

    2012.4 - 2015.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  5. カルシウム結合タンパク質ALG-2による小胞体からの輸送小胞出芽の制御機構の解析

    2009.4 - 2011.3

    科学研究費補助金  若手研究(B)

    柴田 秀樹

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    Authorship:Principal investigator 

  6. カルシウム結合タンパク質ALG-2による小胞体-ゴルジ体間小胞輸送制御機構の解明

    2007

    科学研究費補助金  若手研究(B),課題番号:19770107

    柴田 秀樹

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    Authorship:Principal investigator 

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Teaching Experience (On-campus) 8

  1. 遺伝子の世界

    2020

  2. 応用生命科学実験実習2

    2020

  3. Basics of Bioagricultural Sciences

    2018

  4. 分子細胞生物学特論1

    2018

  5. 応用生命科学実験実習2

    2018

  6. 遺伝子の世界

    2018

  7. 細胞生物学3

    2018

  8. 分子細胞生物学1

    2018

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