Faculty Profiles - MASUTANI, Chikahide

Papers - MASUTANI, Chikahide

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Structure and mechanism of human DNA polymerase h. Reviewed

Biertümpfel, C., Zhao, Y., Kondo, Y., Ramón-Maiques, S., Gregory, M., Lee, J.Y., Masutani, C., Lehmann, A. R., *Hanaoka, F., and *Yang, W.

Nature Vol. 465 page： 1044-1048 2010.6

Polymerization by DNA polymerase h is blocked by cis-diamminedichloroplatinum(II) 1,3-d(GpTpG) crosslink: Implications for cytotoxic effects in nucleotide excision repair-negative tumor cells. Reviewed

Chijiwa, S., Masutani, C., Hanaoka, F., Iwai, S., and *Kuraoka, I.

Carcinogenesis Vol. 31 page： 388-393 2010.3

Polymerization by DNA polymerase eta is blocked by cis-diamminedichloroplatinum(II) 1,3-d(GpTpG) cross-link: implications for cytotoxic effects in nucleotide excision repair-negative tumor cells.

Chijiwa S, Masutani C, Hanaoka F, Iwai S, Kuraoka I

Carcinogenesis Vol. 31 ( 3 ) page： 388 - 93 2010.3

The Molecular Chaperone Hsp90 Regulates Accumulation of DNA Polymerase eta at Replication Stalling Sites in UV-Irradiated Cells

Sekimoto Takayuki, Oda Tsukasa, Pozo Franklin Mayca, Murakumo Yoshiki, Masutani Chikahide, Hanaoka Fumio, Yamashita Takayuki

MOLECULAR CELL Vol. 37 ( 1 ) page： 79 - 89 2010.1

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Molecular Cell

DNA polymerase η (Pol η) is a member of the mammalian Y family polymerases and performs error-free translesion synthesis across UV-damaged DNA. For this function, Pol η accumulates in nuclear foci at replication stalling sites via its interaction with monoubiquitinated PCNA. However, little is known about the posttranslational control mechanisms of Pol η, which regulate its accumulation in replication foci. Here, we report that the molecular chaperone Hsp90 promotes UV irradiation-induced nuclear focus formation of Pol η through control of its stability and binding to monoubiquitinated PCNA. Our data indicate that Hsp90 facilitates the folding of Pol η into an active form in which PCNA- and ubiquitin-binding regions are functional. Furthermore, Hsp90 inhibition potentiates UV-induced cytotoxicity and mutagenesis in a Pol η-dependent manner. Our studies identify Hsp90 as an essential regulator of Pol η-mediated translesion synthesis. © 2010 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.molcel.2009.12.015

Web of Science

Scopus

PubMed

Critical amino acids involved in erroneous incorporation of oxidized nucleotides by human DNA polymerase h and k. Reviewed

Katafuchi, A., Sassa, A., Niimi, N., Gruz, P., Fujimoto, H., Masutani, C., Hanaoka, F., Ohta, T., and *Nohmi, T.

Nucl. Acids Res. Vol. 38 page： 859-867 2010.1

The molecular chaperone Hsp90 regulates accumulation of DNA polymerase h at replication stalling sites in UV-irradiated cells. Reviewed

Sekimoto, T., Oda, T., Pozo, F. M., Murakumo, Y., Masutani, C., Hanaoka, F., and *Yamashita, T.

Mol. Cell Vol. 37 page： 79-89 2010.1

Critical amino acids in human DNA polymerases eta and kappa involved in erroneous incorporation of oxidized nucleotides.

Katafuchi A, Sassa A, Niimi N, Grúz P, Fujimoto H, Masutani C, Hanaoka F, Ohta T, Nohmi T

Nucleic acids research Vol. 38 ( 3 ) page： 859 - 67 2010.1

A novel interaction between human DNA polymerase h and MutLa. Reviewed

Kanao, R., Hanaoka, F., and *Masutani, C.

Biochem. Biophys. Res. Commun. Vol. 389 page： 40-45 2009.11

Translesional DNA synthesis through a C8-guanyl adduct of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in vitro: REV1 inserts dC opposite the lesion and DNA polymerase k potentially catalyzes extension reaction from the 3'-dC terminus. Reviewed

Fukuda, H., Takamura-Enya, T., Masuda, Y., Nohmi, T., Seki, C., Kamiya, K., Sugimura, T., Masutani, C., Hanaoka, F., and *Nakagama, H.

J. Biol. Chem. Vol. 284 page： 25585-25592 2009.9

Interaction with DNA polymerase h is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells. Reviewed

Akagi, J., *Masutani, C., Kataoka, Y., Kan, T., Ohashi, E., Mori, T., Ohmori, H., and Hanaoka, F.

DNA Repair Vol. 8 page： 585-599 2009.5

Penicilliols A and B, novel inhibitors specific to mammalian Y-family DNA polymerases. Reviewed

Kimura, T., Takeuchi, T., Kumamoto-Yonezawa, Y., Ohashi, E., Ohmori, H., Masutani, C., Hanaoka, F., Sugawara, F., Yoshida, H., and *Mizushina, Y.

Bioorg. Medicinal Chem. Vol. 17 page： 1811-1816 2009.3

Specificity of mutations induced by incorporation of oxidized dNTPs into DNA by human DNA polymerase h. Reviewed

Hidaka, K., Yamada, M., Kamiya, H., Masutani, C., Harashima, H., Hanaoka, F., and *Nohmi, T.

DNA Repair Vol. 7 page： 497-506 2008

Miscoding property of 2'-deoxyinosine, a nitric oxide-derived DNA adduct, during translesion synthesis catalyzed by human DNA polymerases. Reviewed

*Yasui, M., Suenaga, E., Koyama, N., Masutani, C., Hanaoka, F., Gruz, P., Shibutani, S., Nohmi, T., Hayashi, M., and Honma, M.

J. Mol. Biol. Vol. 377 page： 1015-1023 2008

Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymerase h. Reviewed

Shimizu, M., Gruz, P., Kamiya, H., Masutani, C., Xu, Y., Sugiyama, H., Harashima, H., Hanaoka, F., and Nohmi, T.

Biochemistry Vol. 46 page： 5515-5522 2007

A second PCNA loader complex, Ctf18-RFC, specifically stimulates DNA polymerase h activity. Reviewed

Shiomi, Y., Masutani, C., Hanaoka, F., Kimura, H., and *Tsurimoto, T.

J. Biol. Chem. Vol. 282 page： 20906-20914 2007

2-Hydroxy-2'-deoxyadenosine 5'-triphosphate enhances A.T --> C.G mutations caused by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate by suppressing its degradation upon replication in a HeLa extract. Reviewed

Satou, K., Kasai, H., Masutani, C., Hanaoka, F., Harashima, H., and Kamiya, H.

Biochemistry Vol. 46 page： 6639-6646 2007

DNA polymerase h and q function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes. Reviewed

Masuda, K., Ouchida, R., Hikida, M., Kurosaki, T., Yokoi, M., Masutani, C., Seki, M., Wood, R.D., Hanaoka, F., and O-Wang, J.

J. Biol. Chem. Vol. 282 page： 17387-17394 2007

Deficiency of the Caenorhabditis elegans DNA polymerase h homologue increases sensitivity to UV radiation during germ-line development. Reviewed

Ohkumo, T., Masutani, C., Eki, T., and Hanaoka, F.

Cell Struct. Funct. Vol. 31 page： 29-37 2006

Ultraviolet B radiation induces epithelial tumors in mice lacking Polh and mesenchymal tumors in mice deficient for Poli. Reviewed

Ohkumo, T., Kondo, Y., Yokoi, M., Tsukamoto, T., Yamada, A., Sugimoto, T., Kanao, R., Higashi, Y., Kondoh, H., Tatematsu, M., Masutani, C., and Hanaoka, F.

Mol. Cell. Biol. Vol. 26 page： 7696-7706 2006

A human DNA polymerase h complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest. Reviewed

Yuasa S., M., Masutani, C., Hirano, A., Cohn, M.A., Yamaizumi, M., Nakatani, Y., and Hanaoka, F.

Genes Cells Vol. 11 page： 731-744 2006

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Papers - MASUTANI, Chikahide