Faculty Profiles - SHIMIZU, Takashi

Papers - SHIMIZU, Takashi

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Responses of cerebellar Purkinje cells during fictive optomotor behavior in larval zebrafish. Reviewed

Scalise K., Shimizu T., Hibi M., Sawtell NB.

J Neurophysiol. 2016.8

Establishment of Gal4 transgenic zebrafish lines for analysis of development of cerebellar neural circuitry Reviewed

Takeuchi M, Matsuda K, Yamaguchi S, Asakawa K, Miyasaka N, Lal P, Yoshihara Y, Koga A, Kawakami K, Shimizu T, Hibi M.

Developmental Biology Vol. 1606 ( 16 ) page： doi:10.1016/j.ydbio.2014.09.030 2015.1

Type IV Collagen Controls the Axogenesis of Cerebellar Granule Cells by Regulating Basement Membrane Integrity in Zebrafish. Reviewed

Takeuchi M, Yamaguchi S, Yonemura S, Kakiguchi K, Sato Y, Higashiyama T, Shimizu T, Hibi M.

PLOS genetics page： in press 2015

Development of the Cerebellum and Cerebellar Neural Circuts

Masahiko Hibi and Takashi Shimizu

Developmental Neurobiology 2011.1

Atypical Protein Kinase C Regulates Primary DendriteSpecification of Cerebellar Purkinje Cells by Localizing Golgi Apparatus Reviewed

Koji Tanabe, Shuichi Kani, Takashi Shimizu, Young-Ki Bae, Takaya Abe, Masahiko Hibi

Journal of Neuroscience Vol. 30 page： 16983-16992 2010.12

Proneural gene-linked neurogenesis in zebrafish Reviewed

Shuichi Kani, Young-Ki Bae, Takashi Shimizu, Koji Tanabe, Chie Satou, Michael J. Parson, Ethan Scott, Masahiko Hibi

Developmental Biology Vol. 343 ( 1-2 ) page： 1-17 2010.6

Language：English Publishing type：Research paper (scientific journal)

In mammals, cerebellar neurons are categorized as glutamatergic or GABAergic, and are derived from progenitors that express the proneural genes atoh1 or ptf1a, respectively. Similarly, in the zebrafish, three atoh1 genes, atoh1a, atoh1b, and atoh1c, are expressed in overlapping, but distinct expression domains in the upper rhombic lip (URL): ptf1a is expressed exclusively in the ventricular zone (VZ). We traced the lineages of the cerebellar neurons using transgenic zebrafish lines expressing fluorescent proteins under the control of the proneural genes' regulatory elements. We found the atoh1+ progenitors gave rise not only to granule cells but also to neurons of the ventral mesencephalon. The ptf1a+progenitors generated Purkinje cells. The olig2+ eurydendroid cells, which are glutamatergic and equivalent to the neurons of the deep cerebellar nuclei of mammals, were derived mostly from ptf1a+ progenitors in the VZ, but some originated from the atoh1+ progenitors in the URL. Our data indicate that proneural gene-linked neurogenesis is evolutionarily conserved in the cerebellum among vertebrates.

Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain. Reviewed

Shimizu T, Nakazawa M, Kani S, Bae YK, Shimizu T, Kageyama R, Hibi M.

Development Vol. 137 ( 11 ) page： 1875-1885 2010.6

Language：English Publishing type：Research paper (scientific journal)

Precise control of neuronal differentiation is necessary for generation of a variety of neurons in the forebrain. However, little is known about transcriptional cascades, which initiate forebrain neurogenesis. Here we show that zinc finger genes Fezf1 and Fezf2, which encode transcriptional repressors, are expressed in the early neural stem (progenitor) cells and control neurogenesis in mouse dorsal telencephalon. Fezf1- and Fezf2-deficient forebrains display upregulation of Hes5 and downregulation of neurogenin 2, which is known to be negatively regulated by Hes5. We show that FEZF1 and FEZF2 bind to and directly repress the promoter activity of Hes5. In Fezf1- and Fezf2-deficient telencephalon, the differentiation of neural stem cells into early-born cortical neurons and intermediate progenitors is impaired. Loss of Hes5 suppresses neurogenesis defects in Fezf1- and Fezf2-deficient telencephalon. Our findings reveal that Fezf1 and Fezf2 control differentiation of neural stem cells by repressing Hes5 and, in turn, by derepressing neurogenin 2 in the forebrain.

Syntabulin, a motor protein linker, controls dorsal determination. Reviewed

Nojima H, Rothhämel S, Shimizu T, Kim CH, Yonemura S, Marlow FL, Hibi M.

Vol. 137 ( 6 ) page： 923-933 2010.3

Language：English Publishing type：Research paper (scientific journal)

In amphibian and teleost embryos, the dorsal determinants (DDs) are believed to be initially localized to the vegetal pole and then transported to the prospective dorsal side of the embryo along a microtubule array. The DDs are known to activate the canonical Wnt pathway and thereby promote the expression of genes that induce the dorsal organizer. Here, by identifying the locus of the maternal-effect ventralized mutant tokkaebi, we show that Syntabulin, a linker of the kinesin I motor protein, is essential for dorsal determination in zebrafish. We found that syntabulin mRNA is transported to the vegetal pole during oogenesis through the Bucky ball (Buc)-mediated Balbiani body-dependent pathway, which is necessary for establishment of animal-vegetal (AV) oocyte polarity. We demonstrate that Syntabulin is translocated from the vegetal pole in a microtubule-dependent manner. Our findings suggest that Syntabulin regulates the microtubule-dependent transport of the DDs, and provide evidence for the link between AV and dorsoventral axis formation.

*Anatomy of zebrafish cerebellum and screen for mutations affecting its development. Reviewed

Bae Y.-K, Kani S., Shimizu T., Tanabe K., Nojima H., Kimura Y., Higashijima S., Hibi M.

Developmental Biology Vol. 336 page： 406-426 2009

Initial specification of the epibranchial placode in zebrafish embryos depends on the fibroblast growth factor signal. Reviewed

Nikaido, M., Doi, K., Shimizu, T., Hibi, M., Kikuchi, Y., Yamasu, Y.

Vol. 236 page： 564-571 2007

Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein. Reviewed

Muraoka, O., Shimizu, T., Yabe, T., Nojima, H., Bae, Y.-K., Hashimoto, H., Hibi, M.

Nature Cell Biology Vol. 8 page： 329-338 2006

*Cdx-Hox code controls competence for responding to Fgfs and retinoic acid in zebrafish neural tissue. Reviewed

Shimizu, T., Bae, Y.-K., Hibi, M.

Development Vol. 133 page： 4709-4719 2006

*E-cadherin is required for gastrulation movements in zebrafish. Reviewed

Shimizu , T., Yabe, T., Muraoka, O., Yonemura S., Aramaki, S., Hatta, K., Bae, Y.-K., Nojima, H., Hibi, M.

Mechanisms of development Vol. 122 page： 747-763 2005

*Interaction of Wnt and caudal-related genes in zebrafish posterior body formation. Reviewed

Shimizu , T., Bae, Y.-K., Muraoka, O., Hibi, M.

Developmental Biology Vol. 279 page： 125-141 2005

Patterning of proneuronal and inter-proneuronal domains by hairy- and enhancer of split-related genes in zebrafish neuroectoderm. Reviewed

Bae, Y.-K., Shimizu , T., Hibi, M.

Development Vol. 132 page： 1375-1385 2005

Genetic evidence for involvement of maternally derived Wnt cannonical signaling in dorsal determination in zebrafish. Reviewed

Nojima, H., Shimizu, T., Kim, C.-H., Yabe, T., Bae, Y.-K., Muraoka, O., Hirata, T., Hirano, T., Hibi, M.

Mechanisms of Development Vol. 121 page： 371-386 2004

Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish. Reviewed

Bae, Y.-K., Shimizu, T., Muraoka, O., Yabe, T., Hirata, T., Nojima, H., Hirano, T., Hibi, M.

Gene Expression Patterns Vol. 4 page： 481-486 2004

Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling. Reviewed

Yabe T., Shimizu T., Muraoka O., Bae Y-K., Hirata T., Nojima H., Kawakami A., Hirano T., Hibi M.

Development Vol. 130 page： 2705-2716 2003

A homeobox gene, pnx is involved in the formation of posterior neurons in zebrafish. Reviewed

Bae Y-K., Shimizu T., Yabe T., Kim C-H., Hirata T., Nojima H., Muraoka O., Hirano T., Hibi M.

Development Vol. 130 page： 1853-1865 2003

A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok- mediated dorsal organizer formation in zebrafish. Reviewed

Shimizu T., Yamanaka Y., Nojima H., Yabe Y., Hibi M., HiranoT.

Mechanisms of Development Vol. 118 page： 125-138 2002

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Papers - SHIMIZU, Takashi