Faculty Profiles - SHIMIZU, Takashi

Papers - SHIMIZU, Takashi

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The zebrafish cerebellar neural circuits are involved in orienting behavior Reviewed

S Hosaka, M Hosokawa, M Hibi, T Shimizu

Vol. 11 ( 10 ) 2024.10

Foxp- and Skor-family proteins control differentiation of Purkinje cells from Ptf1a and Neurogenin1-expressing progenitors in zebrafish.

Itoh T, Uehara M, Yura S, Wang JC, Fujii Y, Nakanishi A, Shimizu T, Hibi M

Development (Cambridge, England) 2024.3

A gene regulatory network combining Pax3/7, Sox10 and Mitf generates diverse pigment cell types in medaka and zebrafish

Miyadai, M; Takada, H; Shiraishi, A; Kimura, T; Watakabe, I; Kobayashi, H; Nagao, Y; Naruse, K; Higashijima, SI; Shimizu, T; Kelsh, RN; Hibi, M; Hashimoto, H

DEVELOPMENT Vol. 150 ( 19 ) 2023.10

Optogenetic manipulation of neuronal and cardiomyocyte functions in zebrafish using microbial rhodopsins and adenylyl cyclases. Reviewed

Hagio H, Koyama W, Hosaka S, Song AD, Narantsatsral J, Matsuda K, Shimizu T, Hososhima S, Tsunoda SP, Kandori H, Hibi M.

Elife Vol. 12 ( e83975 ) 2023.8

Optogenetic manipulation of Gq- and Gi/o-coupled receptor signaling in neurons and heart muscle cells. Invited Reviewed

Hagio H, Koyama W, Hosaka S, Song AD, Narantsatsral J, Matsuda K, Sugihara T, Shimizu T, Koyanagi M, Terakita A, Hibi M.

Elife Vol. 12 ( e83974 ) 2023.8

Cfdp1 controls the cell cycle and neural differentiation in the zebrafish cerebellum and retina Reviewed

Vol. 250 ( 11 ) page： 1618 - 1633 2021.11

Involvement of cerebellar neural circuits in active avoidance conditioning in zebrafish Reviewed

Wataru Koyama, Ryo Hosomi, Koji Matsuda, Koichi Kawakami, Masahiko Hibi, Takashi Shimizu

eNeuro Vol. 8 ( 3 ) page： 507 - 520 2021

Gsx2 is required for specification of neurons in the inferior olivary nuclei from Ptf1a-expressing neural progenitors in zebrafish. Reviewed International journal

Tsubasa Itoh, Miki Takeuchi, Marina Sakagami, Kazuhide Asakawa, Kenta Sumiyama, Koichi Kawakami, Takashi Shimizu, Masahiko Hibi

Development (Cambridge, England) Vol. 147 ( 19 ) 2020.10

Language：English Publishing type：Research paper (scientific journal)

Neurons in the inferior olivary nuclei (IO neurons) send climbing fibers to Purkinje cells to elicit functions of the cerebellum. IO neurons and Purkinje cells are derived from neural progenitors expressing the proneural gene ptf1a In this study, we found that the homeobox gene gsx2 was co-expressed with ptf1a in IO progenitors in zebrafish. Both gsx2 and ptf1a zebrafish mutants showed a strong reduction or loss of IO neurons. The expression of ptf1a was not affected in gsx2 mutants, and vice versa. In IO progenitors, the ptf1a mutation increased apoptosis whereas the gsx2 mutation did not, suggesting that ptf1a and gsx2 are regulated independently of each other and have distinct roles. The fibroblast growth factors (Fgf) 3 and 8a, and retinoic acid signals negatively and positively, respectively, regulated gsx2 expression and thereby the development of IO neurons. mafba and Hox genes are at least partly involved in the Fgf- and retinoic acid-dependent regulation of IO neuronal development. Our results indicate that gsx2 mediates the rostro-caudal positional signals to specify the identity of IO neurons from ptf1a-expressing neural progenitors.

DOI： 10.1242/dev.190603

Web of Science

PubMed

Role of Reelin in cell positioning in the cerebellum and the cerebellum-like structure in zebrafish. Reviewed

Nimura T, Itoh T, Hagio H, Hayashi T, Di Donato V, Takeuchi M, Itoh T, Inoguchi F, Sato Y, Yamamoto N, Katsuyama Y, Del Bene F, Shimizu T, Hibi M

Developmental biology Vol. 455 ( 2 ) page： 393 - 408 2019.11

Tracing of Afferent Connections in the Zebrafish Cerebellum Using Recombinant Rabies Virus

Dohaku Ryuji, Yamaguchi Masahiro, Yamamoto Naoyuki, Shimizu Takashi, Osakada Fumitaka, Hibi Masahiko

FRONTIERS IN NEURAL CIRCUITS Vol. 13 2019.4

Roles of maternal wnt8a transcripts in axis formation in zebrafish. Reviewed

Hino H, Nakanishi A, Seki R, Aoki T, Yamaha E, Kawahara A, Shimizu T, Hibi M

Devlopmental Biology Vol. 434 ( 1 ) page： 96-107 2018.2

Roles of maternal wnt8a transcripts in axis formation in zebrafish. International journal

Hino H, Nakanishi A, Seki R, Aoki T, Yamaha E, Kawahara A, Shimizu T, Hibi M

Devlopmental Biology Vol. 434 ( 1 ) page： 96 - 107 2018.2

Language：English Publishing type：Research paper (scientific journal)

In early zebrafish development, the program for dorsal axis formation begins soon after fertilization. Previous studies suggested that dorsal determinants (DDs) localize to the vegetal pole, and are transported to the dorsal blastomeres in a microtubule-dependent manner. The DDs activate the canonical Wnt pathway and induce dorsal-specific genes that are required for dorsal axis formation. Among wnt-family genes, only the wnt8a mRNA is reported to localize to the vegetal pole in oocytes and to induce the dorsal axis, suggesting that Wnt8a is a candidate DD. Here, to reveal the roles of maternal wnt8a, we generated wnt8a mutants by transcription activator-like effector nucleases (TALENs), and established zygotic, maternal, and maternal zygotic wnt8a mutants by germ-line replacement. Zebrafish wnt8a has two open reading frames (ORF1 and ORF2) that are tandemly located in the genome. Although the zygotic ORF1 or ORF2 wnt8a mutants showed little or no axis-formation defects, the ORF1/2 compound mutants showed antero-dorsalized phenotypes, indicating that ORF1 and ORF2 have redundant roles in ventrolateral and posterior tissue formation. Unexpectedly, the maternal wnt8a ORF1/2 mutants showed no axis-formation defects. The maternal-zygotic wnt8a ORF1/2 mutants showed more severe antero-dorsalized phenotypes than the zygotic mutants. These results indicated that maternal wnt8a is dispensable for the initial dorsal determination, but cooperates with zygotic wnt8a for ventrolateral and posterior tissue formation. Finally, we re-examined the maternal wnt genes and found that Wnt6a is an alternative candidate DD.

DOI： 10.1016/j.ydbio.2017.11.016

Web of Science

PubMed

Axis Formation and Its Evolution in Ray-Finned Fish

Hibi Masahiko, Takeuchi Masaki, Hashimoto Hisashi, Shimizu Takashi

REPRODUCTIVE AND DEVELOPMENTAL STRATEGIES: THE CONTINUITY OF LIFE page： 709-+ 2018

Granule cells control recovery from classical conditioned fear responses in the zebrafish cerebellum

Koji Matsuda, Masayuki Yoshida, Koichi Kawakami, Masahiko Hibi, Takashi Shimizu

SCIENTIFIC REPORTS Vol. 7 ( 1 ) page： 11865 2017.9

Language：English Publishing type：Research paper (scientific journal) Publisher：NATURE PUBLISHING GROUP

Although previous studies show that the cerebellum is involved in classical fear conditioning, it is not clear which components in the cerebellum control it or how. We addressed this issue using a delayed fear-conditioning paradigm with late-stage zebrafish larvae, with the light extinguishment as the conditioned stimulus (CS) and an electric shock as the unconditioned stimulus (US). The US induced bradycardia in the restrained larvae. After paired-associate conditioning with the CS and US, a substantial population of the larvae displayed CS-evoked bradycardia responses. To investigate the roles of the zebrafish cerebellum in classical fear conditioning, we expressed botulinum toxin or the Ca2+ indicator GCaMP7a in cerebellar neurons. The botulinum-toxin-dependent inhibition of granule-cell transmissions in the corpus cerebelli (CCe, the medial lobe) did not suppress the CS-evoked bradycardia response, but rather prolonged the response. We identified cerebellar neurons with elevated CS-evoked activity after the conditioning. The CS-evoked activity of these neurons was progressively upregulated during the conditioning and was downregulated with repetition of the unpaired CS. Some of these neurons were activated immediately upon the CS presentation, whereas others were activated after a delay. Our findings indicate that granule cells control the recovery from conditioned fear responses in zebrafish.

DOI： 10.1038/s41598-017-10794-0

Web of Science

PubMed

Granule cells control recovery from classical conditioned fear responses in the zebrafish cerebellum. Reviewed

Matsuda K, Yoshida M, Kawakami K, Hibi M, Shimizu T.

Scientific reports Vol. 7 ( 1 ) 2017.9

Medaka and zebrafish contactin1 mutants as a model for understanding neural circuits for motor coordination. Reviewed

Takeuchi M, Inoue C, Goshima A, Nagao Y, Shimizu K, Miyamoto H, Shimizu T, Hashimoto H, Yonemura S, Kawahara A, Hirata Y, Yoshida M, Hibi M1

Genes to Cells Vol. 22 ( 8 ) page： 723-741 2017.8

Medaka and zebrafish contactin1 mutants as a model for understanding neural circuits for motor coordination

Takeuchi Miki, Inoue Chikako, Goshima Akiko, Nagao Yusuke, Shimizu Koichi, Miyamoto Hiroki, Shimizu Takashi, Hashimoto Hisashi, Yonemura Shigenobu, Kawahara Atsuo, Hirata Yutaka, Yoshida Masayuki, Hibi Masahiko

GENES TO CELLS Vol. 22 ( 8 ) page： 723-741 2017.8

Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. International journal

Miki Takeuchi, Shingo Yamaguchi, Yoshimasa Sakakibara, Takuto Hayashi, Koji Matsuda, Yuichiro Hara, Chiharu Tanegashima, Takashi Shimizu, Shigehiro Kuraku, Masahiko Hibi

The Journal of comparative neurology Vol. 525 ( 7 ) page： 1558 - 1585 2017.5

Language：English Publishing type：Research paper (scientific journal)

The structure of the neural circuitry of the cerebellum, which functions in some types of motor learning and coordination, is generally conserved among vertebrates. However, some cerebellar features are species specific. It is not clear which genes are involved in forming these conserved and species-specific structures and functions. This study uses zebrafish transgenic larvae expressing fluorescent proteins in granule cells, Purkinje cells, or other cerebellar neurons and glial cells to isolate each type of cerebellar cells by fluorescence-activated cell sorting and to profile their gene expressions by RNA sequencing and in situ hybridization. We identify genes that are upregulated in granule cells or Purkinje cells, including many genes that are also expressed in mammalian cerebella. Comparison of the transcriptomes in granule cells and Purkinje cells in zebrafish larvae reveals that more developmental genes are expressed in granule cells, whereas more neuronal-function genes are expressed in Purkinje cells. We show that some genes that are upregulated in granule cells or Purkinje cells are also expressed in the cerebellum-like structures. Our data provide a platform for understanding the development and function of the cerebellar neural circuits in zebrafish and the evolution of cerebellar circuits in vertebrates. J. Comp. Neurol. 525:1558-1585, 2017. © 2016 Wiley Periodicals, Inc.

DOI： 10.1002/cne.24114

Web of Science

PubMed

Evolutionary mechanisms that generate morphology and neural-circuit diversity of the cerebellum

Hibi Masahiko, Matsuda Koji, Takeuchi Miki, Shimizu Takashi, Murakami Yasunori

DEVELOPMENT GROWTH & DIFFERENTIATION Vol. 59 ( 4 ) page： 228-243 2017.5

Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. Reviewed

Takeuchi M., Yamaguchi S., Sakakibara M., Hayashi T., Matsuda K., Hara Y., Tanegashima C., Shimizu T., Kuraku S., Hibi M.

J Comp Neurol. 2016.9

Responses of cerebellar Purkinje cells during fictive optomotor behavior in larval zebrafish. Reviewed

Scalise K., Shimizu T., Hibi M., Sawtell NB.

J Neurophysiol. 2016.8

Establishment of Gal4 transgenic zebrafish lines for analysis of development of cerebellar neural circuitry Reviewed

Takeuchi M, Matsuda K, Yamaguchi S, Asakawa K, Miyasaka N, Lal P, Yoshihara Y, Koga A, Kawakami K, Shimizu T, Hibi M.

Developmental Biology Vol. 1606 ( 16 ) page： doi:10.1016/j.ydbio.2014.09.030 2015.1

Type IV Collagen Controls the Axogenesis of Cerebellar Granule Cells by Regulating Basement Membrane Integrity in Zebrafish. Reviewed

Takeuchi M, Yamaguchi S, Yonemura S, Kakiguchi K, Sato Y, Higashiyama T, Shimizu T, Hibi M.

PLOS genetics page： in press 2015

Development of the Cerebellum and Cerebellar Neural Circuts

Masahiko Hibi and Takashi Shimizu

Developmental Neurobiology 2011.1

Atypical Protein Kinase C Regulates Primary DendriteSpecification of Cerebellar Purkinje Cells by Localizing Golgi Apparatus Reviewed

Koji Tanabe, Shuichi Kani, Takashi Shimizu, Young-Ki Bae, Takaya Abe, Masahiko Hibi

Journal of Neuroscience Vol. 30 page： 16983-16992 2010.12

Proneural gene-linked neurogenesis in zebrafish Reviewed

Shuichi Kani, Young-Ki Bae, Takashi Shimizu, Koji Tanabe, Chie Satou, Michael J. Parson, Ethan Scott, Masahiko Hibi

Developmental Biology Vol. 343 ( 1-2 ) page： 1-17 2010.6

Language：English Publishing type：Research paper (scientific journal)

In mammals, cerebellar neurons are categorized as glutamatergic or GABAergic, and are derived from progenitors that express the proneural genes atoh1 or ptf1a, respectively. Similarly, in the zebrafish, three atoh1 genes, atoh1a, atoh1b, and atoh1c, are expressed in overlapping, but distinct expression domains in the upper rhombic lip (URL): ptf1a is expressed exclusively in the ventricular zone (VZ). We traced the lineages of the cerebellar neurons using transgenic zebrafish lines expressing fluorescent proteins under the control of the proneural genes' regulatory elements. We found the atoh1+ progenitors gave rise not only to granule cells but also to neurons of the ventral mesencephalon. The ptf1a+progenitors generated Purkinje cells. The olig2+ eurydendroid cells, which are glutamatergic and equivalent to the neurons of the deep cerebellar nuclei of mammals, were derived mostly from ptf1a+ progenitors in the VZ, but some originated from the atoh1+ progenitors in the URL. Our data indicate that proneural gene-linked neurogenesis is evolutionarily conserved in the cerebellum among vertebrates.

Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain. Reviewed

Shimizu T, Nakazawa M, Kani S, Bae YK, Shimizu T, Kageyama R, Hibi M.

Development Vol. 137 ( 11 ) page： 1875-1885 2010.6

Language：English Publishing type：Research paper (scientific journal)

Precise control of neuronal differentiation is necessary for generation of a variety of neurons in the forebrain. However, little is known about transcriptional cascades, which initiate forebrain neurogenesis. Here we show that zinc finger genes Fezf1 and Fezf2, which encode transcriptional repressors, are expressed in the early neural stem (progenitor) cells and control neurogenesis in mouse dorsal telencephalon. Fezf1- and Fezf2-deficient forebrains display upregulation of Hes5 and downregulation of neurogenin 2, which is known to be negatively regulated by Hes5. We show that FEZF1 and FEZF2 bind to and directly repress the promoter activity of Hes5. In Fezf1- and Fezf2-deficient telencephalon, the differentiation of neural stem cells into early-born cortical neurons and intermediate progenitors is impaired. Loss of Hes5 suppresses neurogenesis defects in Fezf1- and Fezf2-deficient telencephalon. Our findings reveal that Fezf1 and Fezf2 control differentiation of neural stem cells by repressing Hes5 and, in turn, by derepressing neurogenin 2 in the forebrain.

Syntabulin, a motor protein linker, controls dorsal determination. Reviewed

Nojima H, Rothhämel S, Shimizu T, Kim CH, Yonemura S, Marlow FL, Hibi M.

Vol. 137 ( 6 ) page： 923-933 2010.3

Language：English Publishing type：Research paper (scientific journal)

In amphibian and teleost embryos, the dorsal determinants (DDs) are believed to be initially localized to the vegetal pole and then transported to the prospective dorsal side of the embryo along a microtubule array. The DDs are known to activate the canonical Wnt pathway and thereby promote the expression of genes that induce the dorsal organizer. Here, by identifying the locus of the maternal-effect ventralized mutant tokkaebi, we show that Syntabulin, a linker of the kinesin I motor protein, is essential for dorsal determination in zebrafish. We found that syntabulin mRNA is transported to the vegetal pole during oogenesis through the Bucky ball (Buc)-mediated Balbiani body-dependent pathway, which is necessary for establishment of animal-vegetal (AV) oocyte polarity. We demonstrate that Syntabulin is translocated from the vegetal pole in a microtubule-dependent manner. Our findings suggest that Syntabulin regulates the microtubule-dependent transport of the DDs, and provide evidence for the link between AV and dorsoventral axis formation.

*Anatomy of zebrafish cerebellum and screen for mutations affecting its development. Reviewed

Bae Y.-K, Kani S., Shimizu T., Tanabe K., Nojima H., Kimura Y., Higashijima S., Hibi M.

Developmental Biology Vol. 336 page： 406-426 2009

Initial specification of the epibranchial placode in zebrafish embryos depends on the fibroblast growth factor signal. Reviewed

Nikaido, M., Doi, K., Shimizu, T., Hibi, M., Kikuchi, Y., Yamasu, Y.

Vol. 236 page： 564-571 2007

Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein. Reviewed

Muraoka, O., Shimizu, T., Yabe, T., Nojima, H., Bae, Y.-K., Hashimoto, H., Hibi, M.

Nature Cell Biology Vol. 8 page： 329-338 2006

*Cdx-Hox code controls competence for responding to Fgfs and retinoic acid in zebrafish neural tissue. Reviewed

Shimizu, T., Bae, Y.-K., Hibi, M.

Development Vol. 133 page： 4709-4719 2006

*E-cadherin is required for gastrulation movements in zebrafish. Reviewed

Shimizu , T., Yabe, T., Muraoka, O., Yonemura S., Aramaki, S., Hatta, K., Bae, Y.-K., Nojima, H., Hibi, M.

Mechanisms of development Vol. 122 page： 747-763 2005

*Interaction of Wnt and caudal-related genes in zebrafish posterior body formation. Reviewed

Shimizu , T., Bae, Y.-K., Muraoka, O., Hibi, M.

Developmental Biology Vol. 279 page： 125-141 2005

Patterning of proneuronal and inter-proneuronal domains by hairy- and enhancer of split-related genes in zebrafish neuroectoderm. Reviewed

Bae, Y.-K., Shimizu , T., Hibi, M.

Development Vol. 132 page： 1375-1385 2005

Genetic evidence for involvement of maternally derived Wnt cannonical signaling in dorsal determination in zebrafish. Reviewed

Nojima, H., Shimizu, T., Kim, C.-H., Yabe, T., Bae, Y.-K., Muraoka, O., Hirata, T., Hirano, T., Hibi, M.

Mechanisms of Development Vol. 121 page： 371-386 2004

Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish. Reviewed

Bae, Y.-K., Shimizu, T., Muraoka, O., Yabe, T., Hirata, T., Nojima, H., Hirano, T., Hibi, M.

Gene Expression Patterns Vol. 4 page： 481-486 2004

Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling. Reviewed

Yabe T., Shimizu T., Muraoka O., Bae Y-K., Hirata T., Nojima H., Kawakami A., Hirano T., Hibi M.

Development Vol. 130 page： 2705-2716 2003

A homeobox gene, pnx is involved in the formation of posterior neurons in zebrafish. Reviewed

Bae Y-K., Shimizu T., Yabe T., Kim C-H., Hirata T., Nojima H., Muraoka O., Hirano T., Hibi M.

Development Vol. 130 page： 1853-1865 2003

A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok- mediated dorsal organizer formation in zebrafish. Reviewed

Shimizu T., Yamanaka Y., Nojima H., Yabe Y., Hibi M., HiranoT.

Mechanisms of Development Vol. 118 page： 125-138 2002

DNA damage response pathway in radioadaptive response. Reviewed

Sasaki MS., Ejima Y., Tachibana A., Yamada T., Ishizaki K., Shimizu T.,Nomura T.

Mutation Research Vol. 504 ( 1-2 ) page： 101-118 2002

Stat3 controls cell movements during zebrafish gastrulation. Reviewed

Yamashita S., Miyagi C., Carmany-Rampey A., Shimizu T., Fujii R, Schier A.F., Hirano T.

Developmental Cell Vol. 2 ( 3 ) page： 363-375 2002

Regulation of dharma/bozozok by the Wnt pathway. Reviewed

Ryu, S-L., Fujii, R., Yamanaka, Y., Shimizu, T., Yabe, T., Hirata, T., Hibi, M., Hirano, T.

Developmental Biology Vol. 231 page： 397-409 2001

Expression of the zinc finger fez-like in zebrafish forebrain. Reviewed

Hashimoto H., Yabe T., Hirata T., Shimizu T., Bae Y-K., Yamanaka Y., Hirano T., Hibi M.

Mechanisms of Development Vol. 97 ( 1-2 ) page： 191-195 2000

Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation Reviewed

Hashimoto H, Itoh M, Yamanaka Y, Yamashita S, Shimizu T, Solnica-Krezel L, Hibi M, Hirano T.

Developmental Biology Vol. 217 ( 1 ) page： 138-152 2000

Novel mutations of the FANCG gene causing alternative splicing in Japanese Fanconi anemia. Reviewed

Yamada T, Tachibana A, Shimizu T, Mugishima H, Okubo M, Sasaki MS.

Journal of Human Genetics Vol. 45 ( 3 ) page： 159-166 2000

*Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish Reviewed

Shimizu T, Yamanaka Y, Ryu SL, Hashimoto H, Yabe T, Hirata T, Bae YK, Hibi M, Hirano T.

Mechanisms of Development Vol. 91 ( 1-2 ) page： 293-303 2000

Novel mix-family homeobox genes in zebrafish and their differential regulation. Reviewed

Hirata T, Yamanaka Y, Ryu SL, Shimizu T, Yabe T, Hibi M, Hirano T.

Biochem Biophys Res Commun. Vol. 271 ( 3 ) page： 603-609 2000

Coordinated regulation of radioadaptive response by protein kinase C and p38 mitogen-activated protein kinase. Reviewed

Shimizu T, Kato T Jr, Tachibana A, Sasaki MS.

Exprimental Cell Research Vol. 251 ( 2 ) page： 424-432 1999

Mutation and sequence variability of the FANCA gene in japanese Fanconi amemia.

Tachibana A., Kato T., Ejima Y., Yamada T., Shimizu T., Yang L., Tsunematsu Y., Sasaki MS.

Human Mutation Vol. 37 page： 237-244 1999

Overexpression of neurogenin induces extopic expression of HuC in zebrafish. Reviewed

Kim C.-H., Bae Y.-K., Yamanaka Y., Yamashita S., Shimizu T., Fuji R., Park H.-C., Yeo S.-Y., Huh T.-L., Hibi M., Hirano T.

Neurosci. Lett Vol. 239 page： 113-116 1997

A high prevalence of functional inactivation by methylation modification of p16INK4A/CDKN2/MTS1 gene in primary urothelial cancers. Reviewed

Akao T, Kakehi Y, Itoh N, Ozdemir E, Shimizu T, Tachibana A, Sasaki MS, Yoshida O.

Jpn J Cancer Res. Vol. 88 ( 11 ) page： 1078-1086 1997

Genomic imprinting of the human serotonin-receptor (HTR2) gene involved in development of retinoblastoma. Reviewed

Kato MV, Shimizu T, Nagayoshi M, Kaneko A, Sasaki MS, Ikawa Y.

American Journal of Human Genetics Vol. 59 ( 5 ) page： 1084-1090 1996

Loss of heterozygosity on chromosome 17 and mutation of the p53 gene in retinoblastoma. Reviewed

Kato MV, Shimizu T, Ishizaki K, Kaneko A, Yandell DW, Toguchida J, Sasaki MS.

Cancer Lett. Vol. 106 ( 1 ) page： 75-82 1996

Delayed development of retinoblastoma associated with loss of a maternal allele on chromosome 13. Reviewed

Kato MV, Ishizaki K, Shimizu T, Toguchida J, Kaneko A, Sasaki MS.

Int J Cancer Vol. 64 ( 1 ) page： 3-8 1995

Parental origin of germ-line and somatic mutations in the retinoblastoma gene. Reviewed

Kato MV, Ishizaki K, Shimizu T, Ejima Y, Tanooka H, Takayama J, Kaneko A, Toguchida J, Sasaki MS.

Human Genetics Vol. 94 ( 1 ) page： 31-38 1994

Mutations in the retinoblastoma gene and their expression in somatic and tumor cells of patients with hereditary retinoblastoma. Reviewed

Kato MV, Ishizaki K, Toguchida J, Kaneko A, Takayama J, Tanooka H, Kato T, Shimizu T, Sasaki MS

Human Mutation Vol. 3 ( 1 ) page： 44-51 1994

Detection of mutations of the RB1 gene in retinoblastoma patients by using exon-by-exon PCR-SSCP analysis. Reviewed

Shimizu T, Toguchida J, Kato MV, Kaneko A, Ishizaki K, Sasaki MS.

American Journal of Human Genetics Vol. 54 ( 5 ) page： 793-800 1994

Mutation spectrum of the retinoblastoma gene in osteosarcomas. Reviewed

Wadayama B, Toguchida J, Shimizu T, Ishizaki K, Sasaki MS, Kotoura Y, Yamamuro T.

Cancer Research Vol. 54 ( 11 ) page： 3042-3048 1994

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Papers - SHIMIZU, Takashi