Organization
Graduate School of Science Associate professor
Graduate School
Graduate School of Science
Undergraduate School
School of Science Department of Biological Science
Title
Associate professor
SHIMIZU, Takashi
Degree 1
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Ph.D （ 1996.3 Kyoto University ）
Research Interests 2
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cerebellar
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神経発生
Research Areas 3
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Others / Others / General Neuroscience
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Others / Others / Molecular Biology
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Others / Others / Developmental Biology
Current Research Project and SDGs 3
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小脳神経回路の機能解明
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Molecular mechanisms controlling neurogenesis in cerebellum
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Research for axis formation in the vertebrate embryogenesis
Research History 3
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Associate Professor, Bioscience and Biotechnology Center, Nagoya University
2009.11
Country：Japan
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Research scientist, RIKEN Center for Developmental Biology
2002.3 - 2009.10
Country：Japan
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Research Associate, Osaka University School of Medicine
2000.4 - 2002.2
Country：Japan
Education 3
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Kanazawa University Faculty of Pharmaceutical Science Pharmaceutical Sciences
1986.4 - 1990.3
Country： Japan
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Kanazawa University
1990.4 - 1992.3
Country： Japan
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Kyoto University Graduate School, Division of Medicine Radiation Biology and Medicine
1992.4 - 1996.3
Country： Japan
Professional Memberships 3
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The Molecular Biology society of Japan
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Japanese Society of Developmental Biologists
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The Japan Neuroscience Society
Papers 58
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Foxp- and Skor-family proteins control differentiation of Purkinje cells from Ptf1a and Neurogenin1-expressing progenitors in zebrafish.
Itoh T, Uehara M, Yura S, Wang JC, Fujii Y, Nakanishi A, Shimizu T, Hibi M
Development (Cambridge, England) 2024.3
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Miyadai, M; Takada, H; Shiraishi, A; Kimura, T; Watakabe, I; Kobayashi, H; Nagao, Y; Naruse, K; Higashijima, SI; Shimizu, T; Kelsh, RN; Hibi, M; Hashimoto, H
DEVELOPMENT Vol. 150 ( 19 ) 2023.10
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Hagio H, Koyama W, Hosaka S, Song AD, Narantsatsral J, Matsuda K, Shimizu T, Hososhima S, Tsunoda SP, Kandori H, Hibi M.
Elife Vol. 12 ( e83975 ) 2023.8
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Optogenetic manipulation of Gq- and Gi/o-coupled receptor signaling in neurons and heart muscle cells. Invited Reviewed
Hagio H, Koyama W, Hosaka S, Song AD, Narantsatsral J, Matsuda K, Sugihara T, Shimizu T, Koyanagi M, Terakita A, Hibi M.
Elife Vol. 12 ( e83974 ) 2023.8
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Cfdp1 controls the cell cycle and neural differentiation in the zebrafish cerebellum and retina Reviewed
Vol. 250 ( 11 ) page： 1618 - 1633 2021.11
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Involvement of cerebellar neural circuits in active avoidance conditioning in zebrafish Reviewed
Wataru Koyama, Ryo Hosomi, Koji Matsuda, Koichi Kawakami, Masahiko Hibi, Takashi Shimizu
eNeuro Vol. 8 ( 3 ) page： 507 - 520 2021
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Gsx2 is required for specification of neurons in the inferior olivary nuclei from Ptf1a-expressing neural progenitors in zebrafish. Reviewed International journal
Tsubasa Itoh, Miki Takeuchi, Marina Sakagami, Kazuhide Asakawa, Kenta Sumiyama, Koichi Kawakami, Takashi Shimizu, Masahiko Hibi
Development (Cambridge, England) Vol. 147 ( 19 ) 2020.10
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Role of Reelin in cell positioning in the cerebellum and the cerebellum-like structure in zebrafish. Reviewed
Nimura T, Itoh T, Hagio H, Hayashi T, Di Donato V, Takeuchi M, Itoh T, Inoguchi F, Sato Y, Yamamoto N, Katsuyama Y, Del Bene F, Shimizu T, Hibi M
Developmental biology Vol. 455 ( 2 ) page： 393 - 408 2019.11
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Tracing of Afferent Connections in the Zebrafish Cerebellum Using Recombinant Rabies Virus
Dohaku Ryuji, Yamaguchi Masahiro, Yamamoto Naoyuki, Shimizu Takashi, Osakada Fumitaka, Hibi Masahiko
FRONTIERS IN NEURAL CIRCUITS Vol. 13 2019.4
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Roles of maternal wnt8a transcripts in axis formation in zebrafish. Reviewed
Hino H, Nakanishi A, Seki R, Aoki T, Yamaha E, Kawahara A, Shimizu T, Hibi M
Devlopmental Biology Vol. 434 ( 1 ) page： 96-107 2018.2
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Roles of maternal wnt8a transcripts in axis formation in zebrafish. International journal
Hino H, Nakanishi A, Seki R, Aoki T, Yamaha E, Kawahara A, Shimizu T, Hibi M
Devlopmental Biology Vol. 434 ( 1 ) page： 96 - 107 2018.2
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Axis Formation and Its Evolution in Ray-Finned Fish
Hibi Masahiko, Takeuchi Masaki, Hashimoto Hisashi, Shimizu Takashi
REPRODUCTIVE AND DEVELOPMENTAL STRATEGIES: THE CONTINUITY OF LIFE page： 709-+ 2018
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Granule cells control recovery from classical conditioned fear responses in the zebrafish cerebellum
Koji Matsuda, Masayuki Yoshida, Koichi Kawakami, Masahiko Hibi, Takashi Shimizu
SCIENTIFIC REPORTS Vol. 7 ( 1 ) page： 11865 2017.9
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Granule cells control recovery from classical conditioned fear responses in the zebrafish cerebellum. Reviewed
Matsuda K, Yoshida M, Kawakami K, Hibi M, Shimizu T.
Scientific reports Vol. 7 ( 1 ) 2017.9
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Medaka and zebrafish contactin1 mutants as a model for understanding neural circuits for motor coordination. Reviewed
Takeuchi M, Inoue C, Goshima A, Nagao Y, Shimizu K, Miyamoto H, Shimizu T, Hashimoto H, Yonemura S, Kawahara A, Hirata Y, Yoshida M, Hibi M1
Genes to Cells Vol. 22 ( 8 ) page： 723-741 2017.8
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Medaka and zebrafish contactin1 mutants as a model for understanding neural circuits for motor coordination
Takeuchi Miki, Inoue Chikako, Goshima Akiko, Nagao Yusuke, Shimizu Koichi, Miyamoto Hiroki, Shimizu Takashi, Hashimoto Hisashi, Yonemura Shigenobu, Kawahara Atsuo, Hirata Yutaka, Yoshida Masayuki, Hibi Masahiko
GENES TO CELLS Vol. 22 ( 8 ) page： 723-741 2017.8
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Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. International journal
Miki Takeuchi, Shingo Yamaguchi, Yoshimasa Sakakibara, Takuto Hayashi, Koji Matsuda, Yuichiro Hara, Chiharu Tanegashima, Takashi Shimizu, Shigehiro Kuraku, Masahiko Hibi
The Journal of comparative neurology Vol. 525 ( 7 ) page： 1558 - 1585 2017.5
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Evolutionary mechanisms that generate morphology and neural-circuit diversity of the cerebellum
Hibi Masahiko, Matsuda Koji, Takeuchi Miki, Shimizu Takashi, Murakami Yasunori
DEVELOPMENT GROWTH & DIFFERENTIATION Vol. 59 ( 4 ) page： 228-243 2017.5
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Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. Reviewed
Takeuchi M., Yamaguchi S., Sakakibara M., Hayashi T., Matsuda K., Hara Y., Tanegashima C., Shimizu T., Kuraku S., Hibi M.
J Comp Neurol. 2016.9
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Responses of cerebellar Purkinje cells during fictive optomotor behavior in larval zebrafish. Reviewed
Scalise K., Shimizu T., Hibi M., Sawtell NB.
J Neurophysiol. 2016.8
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Establishment of Gal4 transgenic zebrafish lines for analysis of development of cerebellar neural circuitry Reviewed
Takeuchi M, Matsuda K, Yamaguchi S, Asakawa K, Miyasaka N, Lal P, Yoshihara Y, Koga A, Kawakami K, Shimizu T, Hibi M.
Developmental Biology Vol. 1606 ( 16 ) page： doi:10.1016/j.ydbio.2014.09.030 2015.1
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Type IV Collagen Controls the Axogenesis of Cerebellar Granule Cells by Regulating Basement Membrane Integrity in Zebrafish. Reviewed
Takeuchi M, Yamaguchi S, Yonemura S, Kakiguchi K, Sato Y, Higashiyama T, Shimizu T, Hibi M.
PLOS genetics page： in press 2015
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Development of the Cerebellum and Cerebellar Neural Circuts
Masahiko Hibi and Takashi Shimizu
Developmental Neurobiology 2011.1
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Atypical Protein Kinase C Regulates Primary DendriteSpecification of Cerebellar Purkinje Cells by Localizing Golgi Apparatus Reviewed
Koji Tanabe, Shuichi Kani, Takashi Shimizu, Young-Ki Bae, Takaya Abe, Masahiko Hibi
Journal of Neuroscience Vol. 30 page： 16983-16992 2010.12
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Proneural gene-linked neurogenesis in zebrafish Reviewed
Shuichi Kani, Young-Ki Bae, Takashi Shimizu, Koji Tanabe, Chie Satou, Michael J. Parson, Ethan Scott, Masahiko Hibi
Developmental Biology Vol. 343 ( 1-2 ) page： 1-17 2010.6
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Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain. Reviewed
Shimizu T, Nakazawa M, Kani S, Bae YK, Shimizu T, Kageyama R, Hibi M.
Development Vol. 137 ( 11 ) page： 1875-1885 2010.6
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Syntabulin, a motor protein linker, controls dorsal determination. Reviewed
Nojima H, Rothhämel S, Shimizu T, Kim CH, Yonemura S, Marlow FL, Hibi M.
Vol. 137 ( 6 ) page： 923-933 2010.3
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*Anatomy of zebrafish cerebellum and screen for mutations affecting its development. Reviewed
Bae Y.-K, Kani S., Shimizu T., Tanabe K., Nojima H., Kimura Y., Higashijima S., Hibi M.
Developmental Biology Vol. 336 page： 406-426 2009
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Initial specification of the epibranchial placode in zebrafish embryos depends on the fibroblast growth factor signal. Reviewed
Nikaido, M., Doi, K., Shimizu, T., Hibi, M., Kikuchi, Y., Yamasu, Y.
Vol. 236 page： 564-571 2007
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*Cdx-Hox code controls competence for responding to Fgfs and retinoic acid in zebrafish neural tissue. Reviewed
Shimizu, T., Bae, Y.-K., Hibi, M.
Development Vol. 133 page： 4709-4719 2006
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Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein. Reviewed
Muraoka, O., Shimizu, T., Yabe, T., Nojima, H., Bae, Y.-K., Hashimoto, H., Hibi, M.
Nature Cell Biology Vol. 8 page： 329-338 2006
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*E-cadherin is required for gastrulation movements in zebrafish. Reviewed
Shimizu , T., Yabe, T., Muraoka, O., Yonemura S., Aramaki, S., Hatta, K., Bae, Y.-K., Nojima, H., Hibi, M.
Mechanisms of development Vol. 122 page： 747-763 2005
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*Interaction of Wnt and caudal-related genes in zebrafish posterior body formation. Reviewed
Shimizu , T., Bae, Y.-K., Muraoka, O., Hibi, M.
Developmental Biology Vol. 279 page： 125-141 2005
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Patterning of proneuronal and inter-proneuronal domains by hairy- and enhancer of split-related genes in zebrafish neuroectoderm. Reviewed
Bae, Y.-K., Shimizu , T., Hibi, M.
Development Vol. 132 page： 1375-1385 2005
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Genetic evidence for involvement of maternally derived Wnt cannonical signaling in dorsal determination in zebrafish. Reviewed
Nojima, H., Shimizu, T., Kim, C.-H., Yabe, T., Bae, Y.-K., Muraoka, O., Hirata, T., Hirano, T., Hibi, M.
Mechanisms of Development Vol. 121 page： 371-386 2004
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Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish. Reviewed
Bae, Y.-K., Shimizu, T., Muraoka, O., Yabe, T., Hirata, T., Nojima, H., Hirano, T., Hibi, M.
Gene Expression Patterns Vol. 4 page： 481-486 2004
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Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling. Reviewed
Yabe T., Shimizu T., Muraoka O., Bae Y-K., Hirata T., Nojima H., Kawakami A., Hirano T., Hibi M.
Development Vol. 130 page： 2705-2716 2003
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A homeobox gene, pnx is involved in the formation of posterior neurons in zebrafish. Reviewed
Bae Y-K., Shimizu T., Yabe T., Kim C-H., Hirata T., Nojima H., Muraoka O., Hirano T., Hibi M.
Development Vol. 130 page： 1853-1865 2003
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A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok- mediated dorsal organizer formation in zebrafish. Reviewed
Shimizu T., Yamanaka Y., Nojima H., Yabe Y., Hibi M., HiranoT.
Mechanisms of Development Vol. 118 page： 125-138 2002
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DNA damage response pathway in radioadaptive response. Reviewed
Sasaki MS., Ejima Y., Tachibana A., Yamada T., Ishizaki K., Shimizu T.,Nomura T.
Mutation Research Vol. 504 ( 1-2 ) page： 101-118 2002
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Stat3 controls cell movements during zebrafish gastrulation. Reviewed
Yamashita S., Miyagi C., Carmany-Rampey A., Shimizu T., Fujii R, Schier A.F., Hirano T.
Developmental Cell Vol. 2 ( 3 ) page： 363-375 2002
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Regulation of dharma/bozozok by the Wnt pathway. Reviewed
Ryu, S-L., Fujii, R., Yamanaka, Y., Shimizu, T., Yabe, T., Hirata, T., Hibi, M., Hirano, T.
Developmental Biology Vol. 231 page： 397-409 2001
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Expression of the zinc finger fez-like in zebrafish forebrain. Reviewed
Hashimoto H., Yabe T., Hirata T., Shimizu T., Bae Y-K., Yamanaka Y., Hirano T., Hibi M.
Mechanisms of Development Vol. 97 ( 1-2 ) page： 191-195 2000
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Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation Reviewed
Hashimoto H, Itoh M, Yamanaka Y, Yamashita S, Shimizu T, Solnica-Krezel L, Hibi M, Hirano T.
Developmental Biology Vol. 217 ( 1 ) page： 138-152 2000
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Novel mutations of the FANCG gene causing alternative splicing in Japanese Fanconi anemia. Reviewed
Yamada T, Tachibana A, Shimizu T, Mugishima H, Okubo M, Sasaki MS.
Journal of Human Genetics Vol. 45 ( 3 ) page： 159-166 2000
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*Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish Reviewed
Shimizu T, Yamanaka Y, Ryu SL, Hashimoto H, Yabe T, Hirata T, Bae YK, Hibi M, Hirano T.
Mechanisms of Development Vol. 91 ( 1-2 ) page： 293-303 2000
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Novel mix-family homeobox genes in zebrafish and their differential regulation. Reviewed
Hirata T, Yamanaka Y, Ryu SL, Shimizu T, Yabe T, Hibi M, Hirano T.
Biochem Biophys Res Commun. Vol. 271 ( 3 ) page： 603-609 2000
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Coordinated regulation of radioadaptive response by protein kinase C and p38 mitogen-activated protein kinase. Reviewed
Shimizu T, Kato T Jr, Tachibana A, Sasaki MS.
Exprimental Cell Research Vol. 251 ( 2 ) page： 424-432 1999
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Mutation and sequence variability of the FANCA gene in japanese Fanconi amemia.
Tachibana A., Kato T., Ejima Y., Yamada T., Shimizu T., Yang L., Tsunematsu Y., Sasaki MS.
Human Mutation Vol. 37 page： 237-244 1999
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Overexpression of neurogenin induces extopic expression of HuC in zebrafish. Reviewed
Kim C.-H., Bae Y.-K., Yamanaka Y., Yamashita S., Shimizu T., Fuji R., Park H.-C., Yeo S.-Y., Huh T.-L., Hibi M., Hirano T.
Neurosci. Lett Vol. 239 page： 113-116 1997
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A high prevalence of functional inactivation by methylation modification of p16INK4A/CDKN2/MTS1 gene in primary urothelial cancers. Reviewed
Akao T, Kakehi Y, Itoh N, Ozdemir E, Shimizu T, Tachibana A, Sasaki MS, Yoshida O.
Jpn J Cancer Res. Vol. 88 ( 11 ) page： 1078-1086 1997
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Genomic imprinting of the human serotonin-receptor (HTR2) gene involved in development of retinoblastoma. Reviewed
Kato MV, Shimizu T, Nagayoshi M, Kaneko A, Sasaki MS, Ikawa Y.
American Journal of Human Genetics Vol. 59 ( 5 ) page： 1084-1090 1996
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Loss of heterozygosity on chromosome 17 and mutation of the p53 gene in retinoblastoma. Reviewed
Kato MV, Shimizu T, Ishizaki K, Kaneko A, Yandell DW, Toguchida J, Sasaki MS.
Cancer Lett. Vol. 106 ( 1 ) page： 75-82 1996
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Delayed development of retinoblastoma associated with loss of a maternal allele on chromosome 13. Reviewed
Kato MV, Ishizaki K, Shimizu T, Toguchida J, Kaneko A, Sasaki MS.
Int J Cancer Vol. 64 ( 1 ) page： 3-8 1995
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Parental origin of germ-line and somatic mutations in the retinoblastoma gene. Reviewed
Kato MV, Ishizaki K, Shimizu T, Ejima Y, Tanooka H, Takayama J, Kaneko A, Toguchida J, Sasaki MS.
Human Genetics Vol. 94 ( 1 ) page： 31-38 1994
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Mutations in the retinoblastoma gene and their expression in somatic and tumor cells of patients with hereditary retinoblastoma. Reviewed
Kato MV, Ishizaki K, Toguchida J, Kaneko A, Takayama J, Tanooka H, Kato T, Shimizu T, Sasaki MS
Human Mutation Vol. 3 ( 1 ) page： 44-51 1994
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Detection of mutations of the RB1 gene in retinoblastoma patients by using exon-by-exon PCR-SSCP analysis. Reviewed
Shimizu T, Toguchida J, Kato MV, Kaneko A, Ishizaki K, Sasaki MS.
American Journal of Human Genetics Vol. 54 ( 5 ) page： 793-800 1994
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Mutation spectrum of the retinoblastoma gene in osteosarcomas. Reviewed
Wadayama B, Toguchida J, Shimizu T, Ishizaki K, Sasaki MS, Kotoura Y, Yamamuro T.
Cancer Research Vol. 54 ( 11 ) page： 3042-3048 1994
Books 4
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New Principles in Developmental Processes
Hibi M. and Shimizu T.（ Role： Joint author）
Springer 2104.1
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Zebrafish experimental guide
（ Role： Joint author）
2020.11 （ ISBN:978-4-254-17173-0 ）
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魚類発生学の基礎
大久保範聡, 吉崎悟郎, 越田澄人（ Role： Joint author）
恒星社厚生閣 2018.9
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Reproductive and Developmental Strategies
Hibi M, Takeuchi M, Hashimoto H, Shimizu T.（ Role： Joint author , Axis Formation and Its Evolution in Ray-Finned Fish.）
Springer 2018.6
MISC 2
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ゼブラフィッシュを用いた小脳の発生と機能解析 Invited
日比正彦、清水貴史
生体の科学 Vol. 73 ( 4 ) page： 368 - 373 2022.8
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Development and function of the zebrafish cerebellar neuralcircuit Invited
Vol. 72 ( 1 ) page： 3 - 8 2021.2
Presentations 31
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Novel optogenetics tools work efficiently in neurons and myocardium in zebrafish International conference
Wataru Koyama, Hanako Hagio, Aysenur Deniz Song, Shiori Hosaka, Janchiv Narantsatsral, Koji Matsuda, Takashi Shimizu, Mitsumasa Koyanagi, Shoko Hososhima, Satoshi Tsunoda, Akihisa Terakita, Hideki Kandori, Masahiko Hibi
The 28th Japanese Medaka and Zebrafish Meeting 2022.9.1
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Function of the cerebellar neural circuitry in zebrafish social behavior International conference
Shiori Hosaka, Masahiko Hibi, Takashi Shimizu
The 28th Japanese Medaka and Zebrafish Meeting 2022.9.1
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Molecular mechanisms of Purkinje cell differentiation in zebrafish
Mari Uehara, Tsubasa Itoh, Shinnosuke Yura, Akiko Nakanishi, Takashi Shimizu, Masahiko Hibi
The 28th Japanese Medaka and Zebrafish Meeting 2022.9.1
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Involvement of cerebellar neural circuits in fear response conditioning in zebrafish International conference
Wataru koyama, Ryo Hosomi, Koji Mtsuda, Koichi Kawakami, Takashi Shimizu, Masahiko Hibi
2022.6
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Function of the cerebellar neural circuitry in zebrafish social behavior International conference
Shiori Hosaka, Masahiko Hibi, Takashi Shimizu
2022.6
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Optogenetic control of intracellular second messengers in neurons and heart muscle cells International conference
17th International Zebrafish Conference 2022.6 IZFS
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Role of the zebrafish cerebellar neural circutry in social behavior International conference
S. Hosaka, M. Hibi and T.Shimizu
The 27th Japanese Medaka and Zebrafish Meeting 2021.9.17
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Involvement of cerebellar neural circuits in active avoidance conditioning in zebrafish International conference
W. Koyama, R. Hosomi, K. Matsuda, K. Kawakami, M. Hibi and T. Shimizu
The 27the Japanese Medaka and Zebrafish Meeting 2021.9.17
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Investigations of effectivity of novel optogenetic tools controlling intracellular second messengers in neurons and the heart muscle International conference
Wataru Koyama, Hanako Hagio, Aysenur Deniz Cayirtepe, Shiori Hosaka, Janchiv Narantsatsral, Koji Matsuda, Takashi Shimizu, Mitsumasa Koyanagi, Shoko Hososhima, Satoshi P. Tsunoda, Akihisa Terakita, Hideki Kandori, and Masahiko Hibi
The 44th Annual Meeting of the Japan Neuroscience Society 2021.7
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Function of the cerebellar neural circuitry in zebrafish social behavior International conference
Shiori Hosaka, Masahiko Hibi, Takashi Shimizu
The 44th Annual Meeting of the Japan Neuroscience Society 2021.7
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Investigations of effectivity of novel optogenetic tools controlling intracellular second messengers in neurons and the heart muscle International conference
Hagio, H., Koyama, W., Hosaka, S., Narantsatsral, J., Matsuda, K., Shimizu, T., Koyanagi, M., Hosohima, S., Tsunoda, S.P., Terakita, A, Kandori, H, Hibi, M.
26th Japanese Medaka and Zebrafish Meeting 2020.11.21
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Molecular mechanisms that control differentiation of Purkinje cells in zebrafish International conference
Itoh, T., Yura, S., Nakanishi, A., Uehara, M., Shimizu, T., Hibi, M.
26th Japanese Medaka and Zebrafish Meeting 2020.11.21
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Development of novel optogenetic tools controlling intracellular second messengers in neurons International conference
2020.7.31
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Role of cerebellar neural circuitry in active avoidance in zebrafish
2020.7.31
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Transcriptional regulators controlling differentiation of Purkinje cells and inferior olivary nucleus neurons in zebrafish International conference
2020.5 日本発生生物学会
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Molecular mechanisms that control the development of Purkinje cells and inferior olivary nucleus neurons in zebrafish International conference
Itoh, T., Takeuchi, M., Yura, S., Nakanishi, A., Sakagami, M., Uehara, M., Shimizu, T., Hibi, M.
53rd Annual Meeting of the Japanese Society of Developmental Biologists 2020.5
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Cfdp1 regulates cell cycle and differentiation of granule cells in the zebrafish cerebellum.
Shimizu T, Inoue S, Xiaodoing Sun, Hibi M.
2019.5.15
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Optogenetic manipulation of zebrafish neural circuits toward understanding higher order function of the cerebellum. Invited
Shimizu T, Matsuda K, Hibi M.
2018.9.15
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Genetic control for development of cerebellar neurons and neural circuits in zebrafish
Takashi Shimizu, Shuichi Kani, Young-Ki Bae, Koji Tanabe, Ryo Kusuda and Masahiko Hibi
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Neurogenesis in Zebrafish Cerebellum
Takashi Shimizu, Shuichi Kani, Young-Ki Bae, Koji Tanabe, and Masahiko Hibi
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Neurogenesis in Zebrafish Cerebellum International conference
Takashi Shimizu, Shuichi Kani, Young-Ki Bae, Koji Tanabe, and Masahiko Hibi
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Screen for mutations affecting development of zebrafish cerebellum.
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Anterior-posterior patterning of neural tissue by Fgfs,retinoic acid and cdx-hox codes. International conference
5th European Zebrafish Genetics and Development Meeting
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Fgf- and retinoic acid-dependent ectopic formation of posterior hindbrain with altered cdx-hox codes International conference
7th International Conference on Zebrafish Development and Genetics
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cdx遺伝子機能阻害胚における異所的な後方菱脳節の形成
清水貴史、Bae Young-ki、日比正彦
日本発生生物学会第39回大会
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ゼブラフィッシュ初期発生におけるE－カドへリンの役割
日本発生生物学会第38回大会
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ゼブラフィッシュ後方組織形成におけるwntとcaudal遺伝子との相互作用
清水貴史、Bae Young-Ki、村岡修、日比正彦
第27回日本分子生物学会年会
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Interaction of wnt and caudal-related genes in the tail formation. International conference
6th International Conference on Zebrafish Development and Genetics
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ゼブラフィッシュ胚の後方組織形成におけるWntシグナルの役割
清水貴史、Bae Young-Ki、村岡修、日比正彦
日本発生生物学会第37回大会
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Characterization of a maternal-effect mutation that affects the dorsal organizer formation in zebrafish. International conference
3rd European Conference on Zebrafish and Medaka Genetics and Development
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A novel ventrally-expressed homeobox gene,ved, is involved in dharma/bozozok-mediated dorsal organizer formation International conference
5th International Conference on Zebrafish Development and Genetics
KAKENHI (Grants-in-Aid for Scientific Research) 8
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The analysis of the function of cerebellar neural circuitry in fear conditioning
Grant number：18K06333 2018.4 - 2021.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Shimizu Takashi
Authorship：Principal investigator
Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）
In the present study, we attempted to elucidate the role of cerebellar neural circuits in fear conditioning using zebrafish as a model animal. When adult zebrafish are repeatedly exposed to fearful stimuli such as electric shocks (unconditioned stimuli) and harmless stimuli such as lights (conditioned stimuli), they learn the relationship between the two stimuli and show escape behavior when only conditioned stimuli are given. In fish whose cerebellar neural circuits were inhibited, this learning was significantly reduced, indicating that the cerebellum plays an important role in fear conditioning. In addition, social behaviors of the fish with inhibited cerebellar neural circuits were observed to be impaired. These results suggest that the cerebellum is involved not only in motor learning but also in fear conditioning and social behavior.
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恐怖条件付けにおける小脳の役割の解明
2018.4 - 2020.3
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
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ゼブラフィッシュを用いた小脳神経回路の発生とその機能の解析
2013.4 - 2016.3
科学研究費補助金 基盤研究(C)
清水貴史
Authorship：Principal investigator
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ゼブラフィッシュ変異体を用いた小脳発生機構の解析
2010.4 - 2013.3
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
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Cdx-Hoxコードによる神経管前後軸形成機構の分子生物学的研究
2007.4 - 2008.3
科学研究費補助金 基盤研究(C)、19570215
Authorship：Principal investigator
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ゼブラフィッシュ尾形成におけるWntシグナルの役割についての研究
2005.4 - 2006.3
科学研究費補助金 基盤研究(C)、17570185
Authorship：Principal investigator
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ゼブラフィッシュ初期発生における背側オーガナイザー形成機構の解明
2003.4 - 2004.3
科学研究費補助金 基盤研究(C)(2)、15570184
Authorship：Principal investigator
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脊椎動物体軸形成におけるDharma遺伝子の作用機構の解明
2001.4 - 2002.3
科学研究費補助金 基盤研究(C)(2)、13670013
Authorship：Principal investigator
Teaching Experience (On-campus) 15
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生物学基礎II
2021
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基礎生物学演習1
2018
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基礎生化学II
2018
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基礎生物学演習II
2017
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基礎生化学II
2017
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基礎生化学II
2016
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基礎生物学演習II
2016
-
基礎生化学II
2015
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基礎生物学演習II
2015
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基礎生物学演習1
2014
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基礎生化学II
2014
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基礎生化学II
2013
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基礎生物学演習1
2013
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基礎生物学演習2
2012
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First Year Seminar A
2011