Updated on 2022/04/12

写真a

 
SHIMIZU, Takashi
 
Organization
Graduate School of Science Associate professor
Graduate School
Graduate School of Science
Undergraduate School
School of Science Department of Biological Science
Title
Associate professor

Degree 1

  1. Ph.D ( 1996.3   Kyoto University ) 

Research Interests 2

  1. cerebellar

  2. 神経発生

Research Areas 3

  1. Others / Others  / General Neuroscience

  2. Others / Others  / Molecular Biology

  3. Others / Others  / Developmental Biology

Current Research Project and SDGs 3

  1. 小脳神経回路の機能解明

  2. Molecular mechanisms controlling neurogenesis in cerebellum

  3. Research for axis formation in the vertebrate embryogenesis

Research History 3

  1. Associate Professor, Bioscience and Biotechnology Center, Nagoya University

    2009.11

      More details

    Country:Japan

  2. Research scientist, RIKEN Center for Developmental Biology

    2002.3 - 2009.10

      More details

    Country:Japan

  3. Research Associate, Osaka University School of Medicine

    2000.4 - 2002.2

      More details

    Country:Japan

Education 3

  1. Kanazawa University   Faculty of Pharmaceutical Science   Pharmaceutical Sciences

    1986.4 - 1990.3

      More details

    Country: Japan

  2. Kanazawa University

    1990.4 - 1992.3

      More details

    Country: Japan

  3. Kyoto University   Graduate School, Division of Medicine   Radiation Biology and Medicine

    1992.4 - 1996.3

      More details

    Country: Japan

Professional Memberships 3

  1. Japanese Society of Developmental Biologists

  2. The Molecular Biology society of Japan

  3. The Japan Neuroscience Society

 

Papers 54

  1. Cfdp1 controls the cell cycle and neural differentiation in the zebrafish cerebellum and retina Reviewed

      Vol. 250 ( 11 ) page: 1618 - 1633   2021.11

     More details

    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/dvdy.371

    Web of Science

  2. Involvement of cerebellar neural circuits in active avoidance conditioning in zebrafish Reviewed

    Wataru Koyama, Ryo Hosomi, Koji Matsuda, Koichi Kawakami, Masahiko Hibi, Takashi Shimizu

    eNeuro   Vol. 8 ( 3 ) page: 507 - 520   2021

     More details

    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1523/ENEURO.0507-20.2021

    Web of Science

  3. Gsx2 is required for specification of neurons in the inferior olivary nuclei from Ptf1a-expressing neural progenitors in zebrafish Reviewed

    Itoh Tsubasa, Takeuchi Miki, Sakagami Marina, Asakawa Kazuhide, Sumiyama Kenta, Kawakami Koichi, Shimizu Takashi, Hibi Masahiko

    DEVELOPMENT   Vol. 147 ( 19 )   2020.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1242/dev.190603

    Web of Science

  4. Role of Reelin in cell positioning in the cerebellum and the cerebellum-like structure in zebrafish

    Nimura Takayuki, Itoh Tsubasa, Hagio Hanako, Hayashi Takuto, Di Donato Vincenzo, Takeuchi Miki, Itoh Takeaki, Inoguchi Fuduki, Sato Yoshikatsu, Yamamoto Naoyuki, Katsuyama Yu, Del Bene Filippo, Shimizu Takashi, Hibi Masahiko

    DEVELOPMENTAL BIOLOGY   Vol. 455 ( 2 ) page: 393 - 408   2019.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ydbio.2019.07.010

    Web of Science

  5. Tracing of Afferent Connections in the Zebrafish Cerebellum Using Recombinant Rabies Virus

    Dohaku Ryuji, Yamaguchi Masahiro, Yamamoto Naoyuki, Shimizu Takashi, Osakada Fumitaka, Hibi Masahiko

    FRONTIERS IN NEURAL CIRCUITS   Vol. 13   2019.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fncir.2019.00030

    Web of Science

  6. Roles of maternal wnt8a transcripts in axis formation in zebrafish. Reviewed

    Hino H, Nakanishi A, Seki R, Aoki T, Yamaha E, Kawahara A, Shimizu T, Hibi M

    Devlopmental Biology   Vol. 434 ( 1 ) page: 96-107   2018.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ydbio.2017.11.016. Epub 2017 Dec 5.

  7. Roles of maternal wnt8a transcripts in axis formation in zebrafish

    Hino Hiromu, Nakanishi Akiko, Seki Ryoko, Aoki Tsubasa, Yamaha Etsuro, Kawahara Atsuo, Shimizu Takashi, Hibi Masahiko

    DEVELOPMENTAL BIOLOGY   Vol. 434 ( 1 ) page: 96-107   2018.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ydbio.2017.11.016

    Web of Science

  8. Axis Formation and Its Evolution in Ray-Finned Fish

    Hibi Masahiko, Takeuchi Masaki, Hashimoto Hisashi, Shimizu Takashi

    REPRODUCTIVE AND DEVELOPMENTAL STRATEGIES: THE CONTINUITY OF LIFE     page: 709-+   2018

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/978-4-431-56609-0_32

    Web of Science

  9. Granule cells control recovery from classical conditioned fear responses in the zebrafish cerebellum

    Matsuda Koji, Yoshida Masayuki, Kawakami Koichi, Hibi Masahiko, Shimizu Takashi

    SCIENTIFIC REPORTS   Vol. 7   2017.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-10794-0

    Web of Science

  10. Granule cells control recovery from classical conditioned fear responses in the zebrafish cerebellum. Reviewed

    Matsuda K, Yoshida M, Kawakami K, Hibi M, Shimizu T.

    Scientific reports   Vol. 7 ( 1 )   2017.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-10794-0.

  11. Medaka and zebrafish contactin1 mutants as a model for understanding neural circuits for motor coordination. Reviewed

    Takeuchi M, Inoue C, Goshima A, Nagao Y, Shimizu K, Miyamoto H, Shimizu T, Hashimoto H, Yonemura S, Kawahara A, Hirata Y, Yoshida M, Hibi M1

    Genes to Cells   Vol. 22 ( 8 ) page: 723-741   2017.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/gtc.12509. Epub 2017 Jun 22.

  12. Medaka and zebrafish contactin1 mutants as a model for understanding neural circuits for motor coordination

    Takeuchi Miki, Inoue Chikako, Goshima Akiko, Nagao Yusuke, Shimizu Koichi, Miyamoto Hiroki, Shimizu Takashi, Hashimoto Hisashi, Yonemura Shigenobu, Kawahara Atsuo, Hirata Yutaka, Yoshida Masayuki, Hibi Masahiko

    GENES TO CELLS   Vol. 22 ( 8 ) page: 723-741   2017.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/gtc.12509

    Web of Science

  13. Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum

    Takeuchi Miki, Yamaguchi Shingo, Sakakibara Yoshimasa, Hayashi Takuto, Matsuda Koji, Hara Yuichiro, Tanegashima Chiharu, Shimizu Takashi, Kuraku Shigehiro, Hibi Masahiko

    JOURNAL OF COMPARATIVE NEUROLOGY   Vol. 525 ( 7 ) page: 1558-1585   2017.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cne.24114

    Web of Science

  14. Evolutionary mechanisms that generate morphology and neural-circuit diversity of the cerebellum

    Hibi Masahiko, Matsuda Koji, Takeuchi Miki, Shimizu Takashi, Murakami Yasunori

    DEVELOPMENT GROWTH & DIFFERENTIATION   Vol. 59 ( 4 ) page: 228-243   2017.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/dgd.12349

    Web of Science

  15. Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. Reviewed

    Takeuchi M., Yamaguchi S., Sakakibara M., Hayashi T., Matsuda K., Hara Y., Tanegashima C., Shimizu T., Kuraku S., Hibi M.

    J Comp Neurol.     2016.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1002/cne.24114

  16. Responses of cerebellar Purkinje cells during fictive optomotor behavior in larval zebrafish. Reviewed

    Scalise K., Shimizu T., Hibi M., Sawtell NB.

    J Neurophysiol.     2016.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/jn.00042.2016

  17. Establishment of Gal4 transgenic zebrafish lines for analysis of development of cerebellar neural circuitry Reviewed

    Takeuchi M, Matsuda K, Yamaguchi S, Asakawa K, Miyasaka N, Lal P, Yoshihara Y, Koga A, Kawakami K, Shimizu T, Hibi M.

    Developmental Biology   Vol. 1606 ( 16 ) page: doi:10.1016/j.ydbio.2014.09.030   2015.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi:10.1016/j.ydbio.2014.09.030

  18. Type IV Collagen Controls the Axogenesis of Cerebellar Granule Cells by Regulating Basement Membrane Integrity in Zebrafish. Reviewed

    Takeuchi M, Yamaguchi S, Yonemura S, Kakiguchi K, Sato Y, Higashiyama T, Shimizu T, Hibi M.

    PLOS genetics     page: in press   2015

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  19. Development of the Cerebellum and Cerebellar Neural Circuts

    Masahiko Hibi and Takashi Shimizu

    Developmental Neurobiology     2011.1

     More details

    Language:English  

    DOI: 10.1002/dneu.20875

  20. Atypical Protein Kinase C Regulates Primary DendriteSpecification of Cerebellar Purkinje Cells by Localizing Golgi Apparatus Reviewed

    Koji Tanabe, Shuichi Kani, Takashi Shimizu, Young-Ki Bae, Takaya Abe, Masahiko Hibi

    Journal of Neuroscience   Vol. 30   page: 16983-16992   2010.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  21. Proneural gene-linked neurogenesis in zebrafish Reviewed

    Shuichi Kani, Young-Ki Bae, Takashi Shimizu, Koji Tanabe, Chie Satou, Michael J. Parson, Ethan Scott, Masahiko Hibi

    Developmental Biology   Vol. 343 ( 1-2 ) page: 1-17   2010.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    In mammals, cerebellar neurons are categorized as glutamatergic or GABAergic, and are derived from progenitors that express the proneural genes atoh1 or ptf1a, respectively. Similarly, in the zebrafish, three atoh1 genes, atoh1a, atoh1b, and atoh1c, are expressed in overlapping, but distinct expression domains in the upper rhombic lip (URL): ptf1a is expressed exclusively in the ventricular zone (VZ). We traced the lineages of the cerebellar neurons using transgenic zebrafish lines expressing fluorescent proteins under the control of the proneural genes' regulatory elements. We found the atoh1+ progenitors gave rise not only to granule cells but also to neurons of the ventral mesencephalon. The ptf1a+progenitors generated Purkinje cells. The olig2+ eurydendroid cells, which are glutamatergic and equivalent to the neurons of the deep cerebellar nuclei of mammals, were derived mostly from ptf1a+ progenitors in the VZ, but some originated from the atoh1+ progenitors in the URL. Our data indicate that proneural gene-linked neurogenesis is evolutionarily conserved in the cerebellum among vertebrates.

  22. Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain. Reviewed

    Shimizu T, Nakazawa M, Kani S, Bae YK, Shimizu T, Kageyama R, Hibi M.

    Development   Vol. 137 ( 11 ) page: 1875-1885   2010.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Precise control of neuronal differentiation is necessary for generation of a variety of neurons in the forebrain. However, little is known about transcriptional cascades, which initiate forebrain neurogenesis. Here we show that zinc finger genes Fezf1 and Fezf2, which encode transcriptional repressors, are expressed in the early neural stem (progenitor) cells and control neurogenesis in mouse dorsal telencephalon. Fezf1- and Fezf2-deficient forebrains display upregulation of Hes5 and downregulation of neurogenin 2, which is known to be negatively regulated by Hes5. We show that FEZF1 and FEZF2 bind to and directly repress the promoter activity of Hes5. In Fezf1- and Fezf2-deficient telencephalon, the differentiation of neural stem cells into early-born cortical neurons and intermediate progenitors is impaired. Loss of Hes5 suppresses neurogenesis defects in Fezf1- and Fezf2-deficient telencephalon. Our findings reveal that Fezf1 and Fezf2 control differentiation of neural stem cells by repressing Hes5 and, in turn, by derepressing neurogenin 2 in the forebrain.

  23. Syntabulin, a motor protein linker, controls dorsal determination. Reviewed

    Nojima H, Rothhämel S, Shimizu T, Kim CH, Yonemura S, Marlow FL, Hibi M.

      Vol. 137 ( 6 ) page: 923-933   2010.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    In amphibian and teleost embryos, the dorsal determinants (DDs) are believed to be initially localized to the vegetal pole and then transported to the prospective dorsal side of the embryo along a microtubule array. The DDs are known to activate the canonical Wnt pathway and thereby promote the expression of genes that induce the dorsal organizer. Here, by identifying the locus of the maternal-effect ventralized mutant tokkaebi, we show that Syntabulin, a linker of the kinesin I motor protein, is essential for dorsal determination in zebrafish. We found that syntabulin mRNA is transported to the vegetal pole during oogenesis through the Bucky ball (Buc)-mediated Balbiani body-dependent pathway, which is necessary for establishment of animal-vegetal (AV) oocyte polarity. We demonstrate that Syntabulin is translocated from the vegetal pole in a microtubule-dependent manner. Our findings suggest that Syntabulin regulates the microtubule-dependent transport of the DDs, and provide evidence for the link between AV and dorsoventral axis formation.

  24. *Anatomy of zebrafish cerebellum and screen for mutations affecting its development. Reviewed

    Bae Y.-K, Kani S., Shimizu T., Tanabe K., Nojima H., Kimura Y., Higashijima S., Hibi M.

    Developmental Biology   Vol. 336   page: 406-426   2009

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  25. Initial specification of the epibranchial placode in zebrafish embryos depends on the fibroblast growth factor signal. Reviewed

    Nikaido, M., Doi, K., Shimizu, T., Hibi, M., Kikuchi, Y., Yamasu, Y.

      Vol. 236   page: 564-571   2007

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  26. Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein. Reviewed

    Muraoka, O., Shimizu, T., Yabe, T., Nojima, H., Bae, Y.-K., Hashimoto, H., Hibi, M.

    Nature Cell Biology   Vol. 8   page: 329-338   2006

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  27. *Cdx-Hox code controls competence for responding to Fgfs and retinoic acid in zebrafish neural tissue. Reviewed

    Shimizu, T., Bae, Y.-K., Hibi, M.

    Development   Vol. 133   page: 4709-4719   2006

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  28. *E-cadherin is required for gastrulation movements in zebrafish. Reviewed

    Shimizu , T., Yabe, T., Muraoka, O., Yonemura S., Aramaki, S., Hatta, K., Bae, Y.-K., Nojima, H., Hibi, M.

    Mechanisms of development   Vol. 122   page: 747-763   2005

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  29. *Interaction of Wnt and caudal-related genes in zebrafish posterior body formation. Reviewed

    Shimizu , T., Bae, Y.-K., Muraoka, O., Hibi, M.

    Developmental Biology   Vol. 279   page: 125-141   2005

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  30. Patterning of proneuronal and inter-proneuronal domains by hairy- and enhancer of split-related genes in zebrafish neuroectoderm. Reviewed

    Bae, Y.-K., Shimizu , T., Hibi, M.

    Development   Vol. 132   page: 1375-1385   2005

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  31. Genetic evidence for involvement of maternally derived Wnt cannonical signaling in dorsal determination in zebrafish. Reviewed

    Nojima, H., Shimizu, T., Kim, C.-H., Yabe, T., Bae, Y.-K., Muraoka, O., Hirata, T., Hirano, T., Hibi, M.

    Mechanisms of Development   Vol. 121   page: 371-386   2004

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  32. Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish. Reviewed

    Bae, Y.-K., Shimizu, T., Muraoka, O., Yabe, T., Hirata, T., Nojima, H., Hirano, T., Hibi, M.

    Gene Expression Patterns   Vol. 4   page: 481-486   2004

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  33. Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling. Reviewed

    Yabe T., Shimizu T., Muraoka O., Bae Y-K., Hirata T., Nojima H., Kawakami A., Hirano T., Hibi M.

    Development   Vol. 130   page: 2705-2716   2003

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  34. A homeobox gene, pnx is involved in the formation of posterior neurons in zebrafish. Reviewed

    Bae Y-K., Shimizu T., Yabe T., Kim C-H., Hirata T., Nojima H., Muraoka O., Hirano T., Hibi M.

    Development   Vol. 130   page: 1853-1865   2003

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  35. A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok- mediated dorsal organizer formation in zebrafish. Reviewed

    Shimizu T., Yamanaka Y., Nojima H., Yabe Y., Hibi M., HiranoT.

    Mechanisms of Development   Vol. 118   page: 125-138   2002

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  36. DNA damage response pathway in radioadaptive response. Reviewed

    Sasaki MS., Ejima Y., Tachibana A., Yamada T., Ishizaki K., Shimizu T.,Nomura T.

    Mutation Research   Vol. 504 ( 1-2 ) page: 101-118   2002

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  37. Stat3 controls cell movements during zebrafish gastrulation. Reviewed

    Yamashita S., Miyagi C., Carmany-Rampey A., Shimizu T., Fujii R, Schier A.F., Hirano T.

    Developmental Cell   Vol. 2 ( 3 ) page: 363-375   2002

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  38. Regulation of dharma/bozozok by the Wnt pathway. Reviewed

    Ryu, S-L., Fujii, R., Yamanaka, Y., Shimizu, T., Yabe, T., Hirata, T., Hibi, M., Hirano, T.

    Developmental Biology   Vol. 231   page: 397-409   2001

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  39. Expression of the zinc finger fez-like in zebrafish forebrain. Reviewed

    Hashimoto H., Yabe T., Hirata T., Shimizu T., Bae Y-K., Yamanaka Y., Hirano T., Hibi M.

    Mechanisms of Development   Vol. 97 ( 1-2 ) page: 191-195   2000

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  40. Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation Reviewed

    Hashimoto H, Itoh M, Yamanaka Y, Yamashita S, Shimizu T, Solnica-Krezel L, Hibi M, Hirano T.

    Developmental Biology   Vol. 217 ( 1 ) page: 138-152   2000

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  41. Novel mutations of the FANCG gene causing alternative splicing in Japanese Fanconi anemia. Reviewed

    Yamada T, Tachibana A, Shimizu T, Mugishima H, Okubo M, Sasaki MS.

    Journal of Human Genetics   Vol. 45 ( 3 ) page: 159-166   2000

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  42. *Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish Reviewed

    Shimizu T, Yamanaka Y, Ryu SL, Hashimoto H, Yabe T, Hirata T, Bae YK, Hibi M, Hirano T.

    Mechanisms of Development   Vol. 91 ( 1-2 ) page: 293-303   2000

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  43. Novel mix-family homeobox genes in zebrafish and their differential regulation. Reviewed

    Hirata T, Yamanaka Y, Ryu SL, Shimizu T, Yabe T, Hibi M, Hirano T.

    Biochem Biophys Res Commun.   Vol. 271 ( 3 ) page: 603-609   2000

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  44. Coordinated regulation of radioadaptive response by protein kinase C and p38 mitogen-activated protein kinase. Reviewed

    Shimizu T, Kato T Jr, Tachibana A, Sasaki MS.

    Exprimental Cell Research   Vol. 251 ( 2 ) page: 424-432   1999

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  45. Mutation and sequence variability of the FANCA gene in japanese Fanconi amemia.

    Tachibana A., Kato T., Ejima Y., Yamada T., Shimizu T., Yang L., Tsunematsu Y., Sasaki MS.

    Human Mutation   Vol. 37   page: 237-244   1999

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  46. Overexpression of neurogenin induces extopic expression of HuC in zebrafish. Reviewed

    Kim C.-H., Bae Y.-K., Yamanaka Y., Yamashita S., Shimizu T., Fuji R., Park H.-C., Yeo S.-Y., Huh T.-L., Hibi M., Hirano T.

    Neurosci. Lett   Vol. 239   page: 113-116   1997

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  47. A high prevalence of functional inactivation by methylation modification of p16INK4A/CDKN2/MTS1 gene in primary urothelial cancers. Reviewed

    Akao T, Kakehi Y, Itoh N, Ozdemir E, Shimizu T, Tachibana A, Sasaki MS, Yoshida O.

    Jpn J Cancer Res.   Vol. 88 ( 11 ) page: 1078-1086   1997

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  48. Genomic imprinting of the human serotonin-receptor (HTR2) gene involved in development of retinoblastoma. Reviewed

    Kato MV, Shimizu T, Nagayoshi M, Kaneko A, Sasaki MS, Ikawa Y.

    American Journal of Human Genetics   Vol. 59 ( 5 ) page: 1084-1090   1996

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  49. Loss of heterozygosity on chromosome 17 and mutation of the p53 gene in retinoblastoma. Reviewed

    Kato MV, Shimizu T, Ishizaki K, Kaneko A, Yandell DW, Toguchida J, Sasaki MS.

    Cancer Lett.   Vol. 106 ( 1 ) page: 75-82   1996

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  50. Delayed development of retinoblastoma associated with loss of a maternal allele on chromosome 13. Reviewed

    Kato MV, Ishizaki K, Shimizu T, Toguchida J, Kaneko A, Sasaki MS.

    Int J Cancer   Vol. 64 ( 1 ) page: 3-8   1995

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  51. Parental origin of germ-line and somatic mutations in the retinoblastoma gene. Reviewed

    Kato MV, Ishizaki K, Shimizu T, Ejima Y, Tanooka H, Takayama J, Kaneko A, Toguchida J, Sasaki MS.

    Human Genetics   Vol. 94 ( 1 ) page: 31-38   1994

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  52. Mutations in the retinoblastoma gene and their expression in somatic and tumor cells of patients with hereditary retinoblastoma. Reviewed

    Kato MV, Ishizaki K, Toguchida J, Kaneko A, Takayama J, Tanooka H, Kato T, Shimizu T, Sasaki MS

    Human Mutation   Vol. 3 ( 1 ) page: 44-51   1994

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  53. Detection of mutations of the RB1 gene in retinoblastoma patients by using exon-by-exon PCR-SSCP analysis. Reviewed

    Shimizu T, Toguchida J, Kato MV, Kaneko A, Ishizaki K, Sasaki MS.

    American Journal of Human Genetics   Vol. 54 ( 5 ) page: 793-800   1994

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  54. Mutation spectrum of the retinoblastoma gene in osteosarcomas. Reviewed

    Wadayama B, Toguchida J, Shimizu T, Ishizaki K, Sasaki MS, Kotoura Y, Yamamuro T.

    Cancer Research   Vol. 54 ( 11 ) page: 3042-3048   1994

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

▼display all

Books 4

  1. New Principles in Developmental Processes

    Hibi M. and Shimizu T.( Role: Joint author)

    Springer  2104.1 

     More details

    Language:English

    Deciphering Cerebellar Neural Circuitry Involved in Higher Order Functions Using the Zebrafish Model.

  2. Zebrafish experimental guide

    ( Role: Joint author)

    2020.11  ( ISBN:978-4-254-17173-0

     More details

    Total pages:135   Responsible for pages:8   Language:Japanese Book type:Textbook, survey, introduction

  3. 魚類発生学の基礎

    大久保範聡, 吉崎悟郎, 越田澄人( Role: Joint author)

    恒星社厚生閣  2018.9 

     More details

    Language:Japanese Book type:Textbook, survey, introduction

  4. Reproductive and Developmental Strategies

    Hibi M, Takeuchi M, Hashimoto H, Shimizu T.( Role: Joint author ,  Axis Formation and Its Evolution in Ray-Finned Fish.)

    Springer  2018.6 

     More details

    Responsible for pages:33   Language:English Book type:Scholarly book

MISC 1

  1. Development and function of the zebrafish cerebellar neuralcircuit Invited

      Vol. 72 ( 1 ) page: 3 - 8   2021.2

     More details

    Authorship:Lead author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (other)  

Presentations 25

  1. Role of the zebrafish cerebellar neural circutry in social behavior International conference

    S. Hosaka, M. Hibi and T.Shimizu

    The 27th Japanese Medaka and Zebrafish Meeting  2021.9.17 

     More details

    Event date: 2021.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Tsukuba  

  2. Involvement of cerebellar neural circuits in active avoidance conditioning in zebrafish International conference

    W. Koyama, R. Hosomi, K. Matsuda, K. Kawakami, M. Hibi and T. Shimizu

    The 27the Japanese Medaka and Zebrafish Meeting  2021.9.17 

     More details

    Event date: 2021.9

    Language:English   Presentation type:Poster presentation  

    Venue:Tsukuba  

  3. Investigations of effectivity of novel optogenetic tools controlling intracellular second messengers in neurons and the heart muscle International conference

    Wataru Koyama, Hanako Hagio, Aysenur Deniz Cayirtepe, Shiori Hosaka, Janchiv Narantsatsral, Koji Matsuda, Takashi Shimizu, Mitsumasa Koyanagi, Shoko Hososhima, Satoshi P. Tsunoda, Akihisa Terakita, Hideki Kandori, and Masahiko Hibi

    The 44th Annual Meeting of the Japan Neuroscience Society  2021.7 

     More details

    Event date: 2021.7

    Language:English   Presentation type:Poster presentation  

  4. Function of the cerebellar neural circuitry in zebrafish social behavior International conference

    Shiori Hosaka, Masahiko Hibi, Takashi Shimizu

    The 44th Annual Meeting of the Japan Neuroscience Society  2021.7 

     More details

    Event date: 2021.7

    Language:English   Presentation type:Poster presentation  

  5. Investigations of effectivity of novel optogenetic tools controlling intracellular second messengers in neurons and the heart muscle International conference

    Hagio, H., Koyama, W., Hosaka, S., Narantsatsral, J., Matsuda, K., Shimizu, T., Koyanagi, M., Hosohima, S., Tsunoda, S.P., Terakita, A, Kandori, H, Hibi, M.

    26th Japanese Medaka and Zebrafish Meeting  2020.11.21 

     More details

    Event date: 2020.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  6. Molecular mechanisms that control differentiation of Purkinje cells in zebrafish International conference

    Itoh, T., Yura, S., Nakanishi, A., Uehara, M., Shimizu, T., Hibi, M.

    26th Japanese Medaka and Zebrafish Meeting  2020.11.21 

     More details

    Event date: 2020.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  7. Development of novel optogenetic tools controlling intracellular second messengers in neurons International conference

    2020.7.31 

     More details

    Event date: 2020.7 - 2020.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  8. Role of cerebellar neural circuitry in active avoidance in zebrafish

    2020.7.31 

     More details

    Event date: 2020.7 - 2020.8

    Language:English   Presentation type:Poster presentation  

  9. Transcriptional regulators controlling differentiation of Purkinje cells and inferior olivary nucleus neurons in zebrafish International conference

    2020.5  日本発生生物学会

     More details

    Event date: 2020.5

    Language:English   Presentation type:Poster presentation  

    Venue:オンライン  

  10. Molecular mechanisms that control the development of Purkinje cells and inferior olivary nucleus neurons in zebrafish International conference

    Itoh, T., Takeuchi, M., Yura, S., Nakanishi, A., Sakagami, M., Uehara, M., Shimizu, T., Hibi, M.

    53rd Annual Meeting of the Japanese Society of Developmental Biologists  2020.5 

     More details

    Event date: 2020.5

    Language:English   Presentation type:Poster presentation  

  11. Cfdp1 regulates cell cycle and differentiation of granule cells in the zebrafish cerebellum.

    Shimizu T, Inoue S, Xiaodoing Sun, Hibi M.

    2019.5.15 

     More details

    Event date: 2019.5

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  12. Optogenetic manipulation of zebrafish neural circuits toward understanding higher order function of the cerebellum. Invited

    Shimizu T, Matsuda K, Hibi M.

    2018.9.15 

     More details

    Event date: 2018.9

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  13. Genetic control for development of cerebellar neurons and neural circuits in zebrafish

    Takashi Shimizu, Shuichi Kani, Young-Ki Bae, Koji Tanabe, Ryo Kusuda and Masahiko Hibi

     More details

    Event date: 2011.5

    Language:English   Presentation type:Poster presentation  

  14. Neurogenesis in Zebrafish Cerebellum

    Takashi Shimizu, Shuichi Kani, Young-Ki Bae, Koji Tanabe, and Masahiko Hibi

     More details

    Event date: 2010.9

    Language:English   Presentation type:Poster presentation  

  15. Neurogenesis in Zebrafish Cerebellum International conference

    Takashi Shimizu, Shuichi Kani, Young-Ki Bae, Koji Tanabe, and Masahiko Hibi

     More details

    Event date: 2010.6

    Language:English   Presentation type:Poster presentation  

  16. Screen for mutations affecting development of zebrafish cerebellum.

     More details

    Event date: 2009.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  17. Anterior-posterior patterning of neural tissue by Fgfs,retinoic acid and cdx-hox codes. International conference

    5th European Zebrafish Genetics and Development Meeting 

     More details

    Event date: 2007.6

    Language:English   Presentation type:Poster presentation  

  18. Fgf- and retinoic acid-dependent ectopic formation of posterior hindbrain with altered cdx-hox codes International conference

    7th International Conference on Zebrafish Development and Genetics 

     More details

    Event date: 2006.7

    Language:English   Presentation type:Oral presentation (general)  

  19. cdx遺伝子機能阻害胚における異所的な後方菱脳節の形成

    清水貴史、Bae Young-ki、日比正彦

    日本発生生物学会第39回大会 

     More details

    Event date: 2006.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  20. ゼブラフィッシュ初期発生におけるE-カドへリンの役割

    日本発生生物学会第38回大会 

     More details

    Event date: 2005.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  21. ゼブラフィッシュ後方組織形成におけるwntとcaudal遺伝子との相互作用

    清水貴史、Bae Young-Ki、村岡修、日比正彦

    第27回日本分子生物学会年会 

     More details

    Event date: 2004.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  22. Interaction of wnt and caudal-related genes in the tail formation. International conference

    6th International Conference on Zebrafish Development and Genetics 

     More details

    Event date: 2004.7

    Language:English   Presentation type:Poster presentation  

  23. ゼブラフィッシュ胚の後方組織形成におけるWntシグナルの役割

    清水貴史、Bae Young-Ki、村岡修、日比正彦

    日本発生生物学会第37回大会 

     More details

    Event date: 2004.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  24. Characterization of a maternal-effect mutation that affects the dorsal organizer formation in zebrafish. International conference

    3rd European Conference on Zebrafish and Medaka Genetics and Development 

     More details

    Event date: 2003.6

    Language:English   Presentation type:Poster presentation  

  25. A novel ventrally-expressed homeobox gene,ved, is involved in dharma/bozozok-mediated dorsal organizer formation International conference

    5th International Conference on Zebrafish Development and Genetics 

     More details

    Event date: 2002.6

    Language:English   Presentation type:Poster presentation  

▼display all

KAKENHI (Grants-in-Aid for Scientific Research) 8

  1. The analysis of the function of cerebellar neural circuitry in fear conditioning

    Grant number:18K06333  2018.4 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Shimizu Takashi

      More details

    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    In the present study, we attempted to elucidate the role of cerebellar neural circuits in fear conditioning using zebrafish as a model animal. When adult zebrafish are repeatedly exposed to fearful stimuli such as electric shocks (unconditioned stimuli) and harmless stimuli such as lights (conditioned stimuli), they learn the relationship between the two stimuli and show escape behavior when only conditioned stimuli are given. In fish whose cerebellar neural circuits were inhibited, this learning was significantly reduced, indicating that the cerebellum plays an important role in fear conditioning. In addition, social behaviors of the fish with inhibited cerebellar neural circuits were observed to be impaired. These results suggest that the cerebellum is involved not only in motor learning but also in fear conditioning and social behavior.

  2. 恐怖条件付けにおける小脳の役割の解明

    2018.4 - 2020.3

    科学研究費補助金  基盤研究(C)

      More details

    Authorship:Principal investigator 

  3. ゼブラフィッシュを用いた小脳神経回路の発生とその機能の解析

    2013.4 - 2016.3

    科学研究費補助金  基盤研究(C)

    清水貴史

      More details

    Authorship:Principal investigator 

  4. ゼブラフィッシュ変異体を用いた小脳発生機構の解析

    2010.4 - 2013.3

    科学研究費補助金  基盤研究(C)

      More details

    Authorship:Principal investigator 

  5. Cdx-Hoxコードによる神経管前後軸形成機構の分子生物学的研究

    2007.4 - 2008.3

    科学研究費補助金  基盤研究(C)、19570215

      More details

    Authorship:Principal investigator 

  6. ゼブラフィッシュ尾形成におけるWntシグナルの役割についての研究

    2005.4 - 2006.3

    科学研究費補助金  基盤研究(C)、17570185

      More details

    Authorship:Principal investigator 

  7. ゼブラフィッシュ初期発生における背側オーガナイザー形成機構の解明

    2003.4 - 2004.3

    科学研究費補助金  基盤研究(C)(2)、15570184

      More details

    Authorship:Principal investigator 

  8. 脊椎動物体軸形成におけるDharma遺伝子の作用機構の解明

    2001.4 - 2002.3

    科学研究費補助金  基盤研究(C)(2)、13670013

      More details

    Authorship:Principal investigator 

▼display all

 

Teaching Experience (On-campus) 15

  1. 生物学基礎II

    2021

  2. 基礎生物学演習1

    2018

  3. 基礎生化学II

    2018

  4. 基礎生物学演習II

    2017

  5. 基礎生化学II

    2017

  6. 基礎生化学II

    2016

  7. 基礎生物学演習II

    2016

  8. 基礎生化学II

    2015

  9. 基礎生物学演習II

    2015

  10. 基礎生物学演習1

    2014

  11. 基礎生化学II

    2014

  12. 基礎生化学II

    2013

  13. 基礎生物学演習1

    2013

  14. 基礎生物学演習2

    2012

  15. First Year Seminar A

    2011

▼display all