Updated on 2024/07/24

写真a

 
UEYAMA, Jun
 
Organization
Graduate School of Medicine Associate professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Health Sciences
Title
Associate professor
Contact information
メールアドレス
External link

Degree 1

  1. 博士(医学) ( 2009.3   金沢大学 ) 

Research Interests 1

  1. 環境検査学・病態検査学

Current Research Project and SDGs 3

  1. 農薬曝露評価に向けたヒトバイオモニタリング手法の開発

  2. 尿中化学物質の網羅的分析による農薬類曝露マーカーの探索と分析法の開発

  3. Biomonitoring method for neonicotinoid insecticides in urine of non-toilet-trained children using LC-MS/MS

Research History 4

  1. Nagoya University   Graduate School of Medicine   Associate professor

    2020.4

  2. Nagoya University   Assistant

    2006.4

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    Country:Japan

  3. 名古屋大学医学部附属病院検査部

    2005.4 - 2006.3

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    Country:Japan

  4. 名古屋大学大学院医学系研究科医療技術学専攻教務職員

    2004.4 - 2005.3

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    Country:Japan

Education 2

  1. Kanazawa University   Graduate School, Division of Medical Sciences

    2005.4 - 2009.3

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    Country: Japan

  2. 名古屋大学大学院医学系研究科医療技術学専攻   保健学研究科   医療技術学専攻

    2002.4 - 2004.3

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    Country: Japan

Professional Memberships 8

  1. The Japanese Society for Hygine   councilor

    2006.6

  2. 日本産業衛生学会   東海産業衛生技術部会委員(2012年から2019年まで)、許容濃度委員会起案委員

    2004.4

  3. Japanese Society for Biomedical Mass Spectrometry   councilor

    2013.4

  4. 日本臨床検査医学会

    2005.4

  5. 日本毒性学会

    2006.4

  6. International Society of Exposure Science

    2011.4

  7. 健康食品管理士会

    2005.4

  8. 日本臨床化学会

    2004.4

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Committee Memberships 8

  1. 名古屋大学   教育・FD委員会委員  

    2020.4   

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    Committee type:Other

  2.   広報・地域貢献委員会委員(2019年度委員長)  

    2016.4 - 2020.3   

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    Committee type:Other

    2018年度は委員長として、ホームカミングデーにおける市民公開講座を主催

  3.   ネットワーク委員会委員  

    2018.4   

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    Committee type:Other

  4.   国際交流委員会委員  

    2014.4 - 2019.3   

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    Committee type:Other

  5.   化学小部会  

    2011.4 - 2022.3   

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    Committee type:Other

  6.   動物実験委員会委員  

    2011.4 - 2016.3   

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    Committee type:Other

  7.   国際交流委員会委員  

    2010.4 - 2012.3   

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    Committee type:Other

  8.   就職委員  

    2006.4 - 2012.3   

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    Committee type:Other

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Awards 7

  1. 日本衛生学会奨励賞

    2017.3   日本衛生学会  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  2. TOBIRA賞

    2019.5   東京バイオマーカー・イノベーション技術研究組合   発色試薬を用いた簡易酸化型アルブミン測定法開発

    上山純

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  3. 若手優秀ポスター賞

    2017.9   日本医用マススペクトル学会  

    上田裕子、上山純

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  4. 優秀発表賞

    2013.8   日本臨床検査学教育学会学術大会  

    本山めぐみ、上山純

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  5. 甕哲司賞

    2010.12   予防医学研究海外研修奨学助成金:甕哲司賞  

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    Country:Japan

  6. 奥谷賞

    2009.6   奥谷賞選考委員会  

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    Country:Japan

    選考委員:奥谷賞記念事業実行委員会会長 深谷幸生(愛知文教女子短期大学教授)名古屋市立大学公衆衛生学教室同門会会長 徳留信寛産業衛生学会東海支部および東海公衆衛生学会の学識経験者

  7. 平成20年度日本衛生学会最優秀論文賞

    2009.3   日本衛生学会  

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    Country:Japan

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Papers 133

  1. Temporal trend and cross-sectional characterization of urinary concentrations of glyphosate in Japanese children from 2006 to 2015. Reviewed

    Nomura H, Hamada R, Wada K, Saito I, Nishihara N, Kitahara Y, Watanabe S, Nakane K, Nagata C, Kondo T, Kamijima M, Ueyama J

    International journal of hygiene and environmental health   Vol. 242   page: 113963   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijheh.2022.113963

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  2. Degranulation and expression of cytokines were modulated by diazinon in activated mast cells.

    Ohdachi T, Matsushima M, Ohara M, Kawashima H, Inoue G, Atsumi K, Tsubosaki Y, Takekoshi M, Ueyama J, Hashimoto N, Sato M, Hasegawa Y, Ishii M, Kawabe T

    Toxicology   Vol. 506   page: 153882   2024.7

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    DOI: 10.1016/j.tox.2024.153882

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  3. Meta-analysis of shotgun sequencing of gut microbiota in Parkinson's disease

    Nishiwaki, H; Ueyama, J; Ito, M; Hamaguchi, T; Takimoto, K; Maeda, T; Kashihara, K; Tsuboi, Y; Mori, H; Kurokawa, K; Katsuno, M; Hirayama, M; Ohno, K

    NPJ PARKINSONS DISEASE   Vol. 10 ( 1 ) page: 106   2024.5

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  4. Density predictive model for an outbreak in adult female Aedes albopictus (Diptera: Culicidae) in Japan

    Watanabe, S; Nakane, K; Kitahara, Y; Nishihara, N; Nomura, H; Fukase, F; Uno, K; Kondo, T; Ueyama, J

    JOURNAL OF MEDICAL ENTOMOLOGY   Vol. 61 ( 2 ) page: 418 - 426   2024.3

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  5. Urinary concentrations and elimination half-lives of parabens, benzophenones, bisphenol and triclosan in Japanese young adults.

    Nguyen HT, Isobe T, Iwai-Shimada M, Takagi M, Ueyama J, Oura K, Tanoue R, Kunisue T, Nakayama SF

    Chemosphere   Vol. 349   page: 140920   2024.2

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  6. Evaluating the risk of phthalate and non-phthalate plasticizers in dust samples from 100 Japanese houses

    Shinohara, N; Oguri, T; Takagi, M; Ueyama, J; Isobe, T

    ENVIRONMENT INTERNATIONAL   Vol. 183   page: 108399   2024.1

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  7. Redox state of human serum albumin predicts 1-year prognosis in patients with heart failure: a single center prospective cohort study

    Nishikawa, T; Ueyama, J; Miyata, S; Shimizu, S; Shibata, Y; Yamada, S

    EUROPEAN HEART JOURNAL   Vol. 44   2023.11

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  8. Association Between the Redox State of Human Serum Albumin and Exercise Capacity in Patients With Cardiac Disease Reviewed

    Ishimaru, Y; Adachi, T; Ashikawa, H; Hori, M; Shimozato, T; Ohtake, H; Shimizu, S; Ueyama, J; Yamada, S

    AMERICAN JOURNAL OF CARDIOLOGY   Vol. 189   page: 56 - 60   2023.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.amjcard.2022.11.034

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  9. Effects of Pesticide Intake on Gut Microbiota and Metabolites in Healthy Adults Reviewed

    Ueyama, J; Hayashi, M; Hirayama, M; Nishiwaki, H; Ito, M; Saito, I; Tsuboi, Y; Isobe, T; Ohno, K

    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH   Vol. 20 ( 1 )   2023.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijerph20010213

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  10. Interpreting biomonitoring data: Introducing the international human biomonitoring (i-HBM) working group's health-based guidance value (HB2GV) dashboard Reviewed International coauthorship

    Nakayama, SF; St-Amand, A; Pollock, T; Apel, P; Bamai, YA; Barr, DB; Bessems, J; Calafat, AM; Castaño, A; Covaci, A; Duca, RC; Faure, S; Galea, KS; Hays, S; Hopf, NB; Ito, Y; Jeddi, MZ; Kolossa-Gehring, M; Kumar, E; LaKind, JS; López, ME; Louro, H; Macey, K; Makris, KC; Melnyk, L; Murawski, A; Naiman, J; Nassif, J; Noisel, N; Poddalgoda, D; Quirós-Alcalá, L; Rafiee, A; Rambaud, L; Silva, MJ; Ueyama, J; Verner, MA; Waras, MN; Werry, K

    INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH   Vol. 247   page: 114046   2023.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijheh.2022.114046

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  11. Gut microbiota in dementia with Lewy bodies Reviewed

    Nishiwaki, H; Ueyama, J; Kashihara, K; Ito, M; Hamaguchi, T; Maeda, T; Tsuboi, Y; Katsuno, M; Hirayama, M; Ohno, K

    NPJ PARKINSONS DISEASE   Vol. 8 ( 1 ) page: 169   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41531-022-00428-2

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  12. Association of Redox State of Human Serum Albumin with Severity in Patients with Heart Failure A Cross-Sectional Study Reviewed

    Nishikawa, T; Shimizu, S; Kamiya, H; Ueyama, J; Yamada, S

    INTERNATIONAL HEART JOURNAL   Vol. 63 ( 6 ) page: 1107 - 1114   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1536/ihj.22-062

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  13. Survey of Arsenic/Heavy Metals and Pesticide Residues in Edible Insects for Human Consumption or Supplied in Japan Reviewed

    Kitahara Yugo, Nomura Hiroshi, Nishihara Nanami, Ueda Takuya, Watanabe Satoru, Saito Isao, Ueyama Jun

    FOOD HYGIENE AND SAFETY SCIENCE   Vol. 63 ( 4 ) page: 136 - 140   2022.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3358/shokueishi.63.136

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  14. Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson's disease Reviewed

    Nishiwaki Hiroshi, Ito Mikako, Hamaguchi Tomonari, Maeda Tetsuya, Kashihara Kenichi, Tsuboi Yoshio, Ueyama Jun, Yoshida Takumi, Hanada Hiroyuki, Takeuchi Ichiro, Katsuno Masahisa, Hirayama Masaaki, Ohno Kinji

    NPJ PARKINSONS DISEASE   Vol. 8 ( 1 ) page: 65   2022.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41531-022-00328-5

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  15. Periosteum-derived podoplanin-expressing stromal cells regulate nascent vascularization during epiphyseal marrow development Reviewed

    Tamura Shogo, Mukaide Masato, Katsuragi Yumi, Fujii Wataru, Odaira Koya, Suzuki Nobuaki, Tsukiji Nagaharu, Okamoto Shuichi, Suzuki Atsuo, Kanematsu Takeshi, Katsumi Akira, Takagi Akira, Ikeda Katsuhide, Ueyama Jun, Hirayama Masaaki, Suzuki-Inoue Katsue, Matsushita Tadashi, Kojima Tetsuhito, Hayakawa Fumihiko

    JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 298 ( 5 ) page: 101833   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jbc.2022.101833

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  16. Simultaneous quantification of pyrethroid metabolites in urine of non-toilet-trained children in Japan Reviewed

    Ueyama Jun, Ito Yuki, Hamada Risa, Oya Naoko, Kato Sayaka, Matsuki Taro, Tamada Hazuki, Kaneko Kayo, Saitoh Shinji, Sugiura-Ogasawara Mayumi, Ebara Takeshi, Kamijima Michihiro

    ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE   Vol. 27 ( 0 ) page: 25   2022

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    DOI: 10.1265/ehpm.21-00037

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  17. Intestinal <i>Collinsella</i> may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate Reviewed

    Hirayama, M; Nishiwaki, H; Hamaguchi, T; Ito, M; Ueyama, J; Maeda, T; Kashihara, K; Tsuboi, Y; Ohno, K

    PLOS ONE   Vol. 16 ( 11 ) page: e0260451   2021.11

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    DOI: 10.1371/journal.pone.0260451

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  18. Human Nonmercaptalbumin Is a New Biomarker of Motor Function Reviewed

    Ito, S; Nakashima, H; Ando, K; Kobayashi, K; Machino, M; Seki, T; Ishizuka, S; Kanbara, S; Inoue, T; Koshimizu, H; Fujii, R; Yamada, H; Ando, Y; Ueyama, J; Kondo, T; Suzuki, K; Hasegawa, Y; Imagama, S

    JOURNAL OF CLINICAL MEDICINE   Vol. 10 ( 11 )   2021.6

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    DOI: 10.3390/jcm10112464

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  19. Association of self-reported moderate vegetable juice intake with small decline in kidney function in a five-year prospective study. Reviewed

    Fujii R, Kondo T, Tsukamoto M, Kawai S, Sasakabe T, Naito M, Kubo Y, Okada R, Tamura T, Hishida A, Ueyama J, Hayashi Y, Ohnishi J, Hamajima N, Takeuchi K, Wakai K

    Nutrition (Burbank, Los Angeles County, Calif.)   Vol. 84   page: 111114   2021.4

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    DOI: 10.1016/j.nut.2020.111114

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  20. Non-linear model analysis of the relationship between cholinesterase activity in rats exposed to 2, 2-dichlorovinyl dimethylphosphate (dichlorvos) and its metabolite concentrations in urine Reviewed

    Sato, H; Ito, Y; Hanai, C; Nishimura, M; Ueyama, J; Kamijima, M

    TOXICOLOGY   Vol. 450   page: 152679   2021.2

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    DOI: 10.1016/j.tox.2021.152679

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  21. Cumulative exposure assessment of neonicotinoids and an investigation into their intake-related factors in young children in Japan. Reviewed

    Oya N, Ito Y, Ebara T, Kato S, Ueyama J, Aoi A, Nomasa K, Sato H, Matsuki T, Sugiura-Ogasawara M, Saitoh S, Kamijima M

    The Science of the total environment   Vol. 750   page: 141630   2021.1

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    DOI: 10.1016/j.scitotenv.2020.141630

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  22. Occupational exposure limits for acetaldehyde, 2-bromopropane, glyphosate, manganese and inorganic manganese compounds, and zinc oxide nanoparticle, and the biological exposure indices for cadmium and cadmium compounds and ethylbenzene, and carcinogenicity, occupational sensitizer, and reproductive toxicant classifications Invited Reviewed

    Araki, A; Azuma, K; Endo, G; Endo, Y; Fukushima, T; Hara, K; Harada, K; Hori, H; Horie, S; Horiguchi, H; Ichiba, M; Ichihara, G; Ishitake, T; Ito, A; Ito, Y; Iwasawa, S; Kakamu, T; Kamijima, M; Karita, K; Kawai, T; Kawamoto, T; Kishi, R; Kumagai, S; Matsumoto, A; Miyagawa, M; Miyauchi, H; Morimoto, Y; Nagano, K; Naito, H; Nakajima, T; Nakano, M; Nomiyama, T; Okuda, H; Okuda, M; Omae, K; Sato, K; Sobue, T; Suwazono, Y; Takebayashi, T; Takeshita, T; Takeuchi, A; Takeuchi, A; Tanaka, S; Tsuji, M; Tsukahara, T; Ueno, S; Ueyama, J; Umeda, Y; Yamamoto, K; Yamano, Y; Yamauchi, T; Yano, E

    JOURNAL OF OCCUPATIONAL HEALTH   Vol. 63 ( 1 )   2021.1

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    DOI: 10.1002/1348-9585.12294

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  23. Optimization and validation of a highly sensitive method for determining glyphosate in human urine by solid-phase extraction and liquid chromatography with tandem mass spectrometry: a methodological study Reviewed

    ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE   Vol. 25 ( 1 ) page: 83   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12199-020-00918-w

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  24. Short-Chain Fatty Acid-Producing Gut Microbiota Is Decreased in Parkinson's Disease but Not in Rapid-Eye-Movement Sleep Behavior Disorder. Reviewed

    Nishiwaki H, Hamaguchi T, Ito M, Ishida T, Maeda T, Kashihara K, Tsuboi Y, Ueyama J, Shimamura T, Mori H, Kurokawa K, Katsuno M, Hirayama M, Ohno K

    mSystems   Vol. 5 ( 6 )   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/mSystems.00797-20

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  25. Meta-Analysisof Gut Dysbiosis in Parkinson's Disease Reviewed

    Nishiwaki Hiroshi, Ito Mikako, Ishida Tomohiro, Hamaguchi Tomonari, Maeda Tetsuya, Kashihara Kenichi, Tsuboi Yoshio, Ueyama Jun, Shimamura Teppei, Mori Hiroshi, Kurokawa Ken, Katsuno Masahisa, Hirayama Masaaki, Ohno Kinji

    MOVEMENT DISORDERS   Vol. 35 ( 9 ) page: 1626 - 1635   2020.9

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    DOI: 10.1002/mds.28119

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  26. Within-individual and interlaboratory variability analyses of urinary metabolites measurements of organophosphorus insecticides Reviewed

    Ito Yuki, Ueyama Jun, Nakayama Shoji F., Isobe Tomohiko, Oya Naoko, Sato Hirotaka, Ebara Takeshi, Yoshimasu Kouichi, Tsuno Kanami, Tatsuta Nozomi, Nakai Kunihiko, Kamijima Michihiro

    JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY   Vol. 30 ( 4 ) page: 721 - 729   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41370-019-0124-7

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  27. Within-individual and interlaboratory variability analyses of urinary metabolites measurements of organophosphorus insecticides Reviewed

    Yuki Ito, Jun Ueyama, Shoji F Nakayama, Tomohiko Isobe, Naoko Oya, Hirotaka Sato, Takeshi Ebara, Kouichi Yoshimasu, Kanami Tsuno, Nozomi Tatsuta, Kunihiko Nakai, Michihiro Kamijima

    J Expo Sci Environ Epidemiol   Vol. 30 ( 4 ) page: 721 - 729   2020.7

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    DOI: DOI: 10.1038/s41370-019-0124-7

  28. Associations between Exposure to Tobacco Smoke and Behavioral Problems in Preschool Japanese Children Reviewed

    Wada Keiko, Ueyama Jun, Konishi Kie, Goto Yuko, Koda Sachi, Mizuta Fumi, Tamura Takashi, Watanabe Kaori, Ando Kyoko, Kondo Takaaki, Nagata Chisato

    JOURNAL OF ENVIRONMENTAL AND PUBLIC HEALTH   Vol. 2020   page: 7591263   2020.5

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    DOI: 10.1155/2020/7591263

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  29. Association between redox state of human serum albumin and exercise capacity in older women: A cross-sectional study Reviewed

    Ashikawa Hironobu, Adachi Takuji, Ueyama Jun, Yamada Sumio

    GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 20 ( 3 ) page: 256 - 260   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ggi.13849

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  30. Ten-year temporal trends (2006-2015) and seasonal-differences in urinary metabolite concentrations of novel, hygiene-used pyrethroids in Japanese children. Reviewed

    Hamada R, Ueda Y, Wada K, Saito I, Nomura H, Kamijima M, Nakane K, Nagata C, Kondo T, Ueyama J.

    Int J Hyg Environ Health   Vol. 225   page: 113448   2020.1

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijheh.2019.113448

  31. Occupational exposure limits for ethyl benzene, dimethyl terephthalate and hydrogen fluoride, and carcinogenicity and reproductive toxicant classifications The Committee for Recommendation of Occupational Exposure Limits, Japan Society for Occupational Health

    Araki Atsuko, Azuma Kenichi, Endo Ginji, Endo Yoko, Fukushima Tetsuhito, Hara Kunio, Hori Hajime, Ichiba Masayoshi, Ishitake Tatsuya, Ichihara Gaku, Ito Akiyoshi, Ito Yuki, Iwasawa Satoko, Kakamu Takeyasu, Kamijima Michihiro, Karita Kanae, Katoh Takahiko, Kawai Toshio, Kawamoto Toshihiro, Kishi Reiko, Kumagai Shinji, Kusaka Yukinori, Miyagawa Muneyuki, Miyauchi Hiroyuki, Morimoto Yasuo, Nagano Kasuke, Naito Hisao, Nakajima Tamie, Nakano Makiko, Nomiyama Tetsuo, Okuda Hirokazu, Okuda Masayuki, Omae Kazuyuki, Sato Kazuhiro, Sobue Tomotaka, Suwazono Yasushi, Takebayashi Toru, Takeshita Tatsuya, Tsukahara Teruomi, Tsunoda Masashi, Ueyama Jun, Umeda Yumi, Yamamoto Kenya, Yamano Yuko, Yamauchi Takenori, Yano Eiji

    JOURNAL OF OCCUPATIONAL HEALTH   Vol. 62 ( 1 )   2020.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/1348-9585.12151

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  32. Biomonitoring method for neonicotinoid insecticides in urine of non-toilet-trained children using LC-MS/MS.

    Ueyama J, Aoi A, Ueda Y, Oya N, Sugiura Y, Ito Y, Ebara T, Kamijima M

    Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment     page: 1-12   2019.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/19440049.2019.1696020

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  33. Prenatal exposure to organophosphate pesticides, maternal paraoxonase 1 genotype, and childhood neurodevelopment at 24 months of age in Shandong, China.

    Wang Y, Zhang Y, Ji L, Zhou Y, Shi R, Kamijima M, Ueyama J, Gao Y, Tian Y

    Environmental science and pollution research international     2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11356-019-06740-4

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  34. Freeze-drying enables homogeneous and stable sample preparation for determination of fecal short-chain fatty acids.

    Ueyama J, Oda M, Hirayama M, Sugitate K, Sakui N, Hamada R, Ito M, Saito I, Ohno K

    Analytical biochemistry     page: 113508   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ab.2019.113508

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  35. Exposure levels of organophosphate pesticides in Japanese diapered children: Contributions of exposure-related behaviors and mothers' considerations of food selection and preparation.

    Oya N, Ito Y, Ebara T, Kato S, Hioki K, Aoi A, Ueyama J, Oguri T, Shoji N, Sugiura-Ogasawara M, Saitoh S, Kamijima M

    Environment international   Vol. 134   page: 105294   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.envint.2019.105294

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  36. Cohort profile: Aichi regional sub-cohort of the Japan Environment and Children's Study (JECS-A) Reviewed

    Takeshi Ebara, Yasuyuki Yamada, Naoto Shoji, Yuki Ito, Atsuko Nakagawa, Taishi Miyachi, Yasuhiko Ozaki, Toyonori Omori, Sadao Suzuki, Masayo Kojima, Jun Ueyama, Motohiro Tomizawa, Sayaka Kato, Tomoko Oguri, Taro Matsuki, Hirotaka Sato, Naoko Oya, Mayumi Sugiura-Ogasawara, Shinji Saitoh, Michihiro Kamijima

    BMJ Open   Vol. 9 ( 11 ) page: e028105   2019.11

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    DOI: DOI: 10.1136/bmjopen-2018-028105

  37. Occupational exposure limits for cumene, 2,4-dichlorophenoxy acetic acid, silicon carbide whisker, benzyl alcohol, and methylamine, and carcinogenicity, occupational sensitizer, and reproductive toxicant classifications

    Araki Atsuko, Azuma Kenichi, Endo Ginji, Endo Yoko, Fukushima Tetsuhito, Hara Kunio, Harada Koji, Hori Hajime, Horie Seichi, Ichiba Masayoshi, Ichihara Gaku, Ikeda Masayuki, Ito Akiyoshi, Ito Yuki, Iwasawa Satoko, Kakumu Takeyasu, Kamijima Michihiro, Karita Kanae, Katoh Takahiko, Kawai Toshio, Kawamoto Toshihiro, Kumagai Shinji, Kusaka Yukinori, Matsumoto Akiko, Miyagawa Muneyuki, Miyauchi Hiroyuki, Morimoto Yasuo, Nagano Kasuke, Naito Hisao, Nakajima Tamie, Nakano Makiko, Nomiyama Tetsuo, Okuda Hirokazu, Okuda Masayuki, Omae Kazuyuki, Sakurai Haruhiko, Sato Kazuhiro, Sobue Tomotaka, Suwazono Yasushi, Takebayashi Toru, Takeshita Tatsuya, Takeuchi Akito, Takeuchi Ayano, Tanaka Masatoshi, Tanaka Shigeru, Tsukahara Teruomi, Tsunoda Masashi, Ueno Susumu, Ueyama Jun, Umeda Yumi, Yamamoto Kenya, Yamano Yuko, Yamauchi Takenori, Yano Eiji

    JOURNAL OF OCCUPATIONAL HEALTH   Vol. 61 ( 4 ) page: 328 - 330   2019.7

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    DOI: 10.1002/1348-9585.12073

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  38. Association between exposure to household smoking and dental caries in preschool children: a cross-sectional study.

    Goto Y, Wada K, Konishi K, Uji T, Koda S, Mizuta F, Yamakawa M, Watanabe K, Ando K, Ueyama J, Kondo T, Nagata C

    Environmental health and preventive medicine   Vol. 24 ( 1 ) page: 9   2019.1

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    DOI: 10.1186/s12199-019-0764-1

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  39. Intra-individual variations of organophosphate pesticide metabolite concentrations in repeatedly collected urine samples from pregnant women in Japan.

    Hioki K, Ito Y, Oya N, Nakayama SF, Isobe T, Ebara T, Shibata K, Nishikawa N, Nakai K, Kamida T, Ueyama J, Sugiura-Ogasawara M, Kamijima M

    Environmental health and preventive medicine   Vol. 24 ( 1 ) page: 7   2019.1

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    DOI: 10.1186/s12199-019-0761-4

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  40. Human Serum Albumin Redox State is Associated with Decreased Renal Function in a Community-Dwelling Population.

    Fujii R, Ueyama J, Kanno T, Suzuki K, Hamajima N, Wakai K, Hasegawa Y, Kondo T

    American journal of physiology. Renal physiology     2018.11

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    DOI: 10.1152/ajprenal.00138.2018

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  41. A sensitive and efficient procedure for the high-throughput determination of nine urinary metabolites of pyrethroids by GC-MS/MS and its application in a sample of Japanese children

    Ueda Yuko, Oda Masaya, Saito Isao, Hamada Risa, Kondo Takaaki, Kamijima Michihiro, Ueyama Jun

    ANALYTICAL AND BIOANALYTICAL CHEMISTRY   Vol. 410 ( 24 ) page: 6207 - 6217   2018.9

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    DOI: 10.1007/s00216-018-1229-x

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  42. A new method for simultaneous quantification of fosphenytoin, phenytoin and its primary metabolite 5-(4-hydroxyphenyl)-5-phenylhydantoin in whole blood by ultra-performance liquid chromatography-tandem mass spectrometry.

    Suzuki T, Ogawa T, Ueyama J, Iwai M, Kondo F, Seno H

    Legal medicine (Tokyo, Japan)   Vol. 34   page: 64-69   2018.9

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    DOI: 10.1016/j.legalmed.2018.08.006

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  43. Occupational Exposure Limits for ethylidene norbornene, ethyleneimine, benomyl, and 2,3-epoxypropyl methacrylate, and classifications on carcinogenicity

    Araki Atsuko, Azuma Kenichi, Endo Ginji, Endo Yoko, Fukushima Tetsuhito, Hara Kunio, Hori Hajime, Horie Seichi, Horiguchi Hyogo, Ichiba Masayoshi, Ichihara Gaku, Ikeda Masayuki, Ishitake Tatsuya, Ito Akiyoshi, Ito Yuki, Iwasawa Satoko, Kakumu Takeyasu, Kamijima Michihiro, Karita Kanae, Katoh Takahiko, Kawai Toshio, Kawamoto Toshihiro, Kumagai Shinji, Kusaka Yukinori, Matsumoto Akiko, Miyagawa Muneyuki, Miyauchi Hiroyuki, Morimoto Yasuo, Nagano Kasuke, Naito Hisao, Nakajima Tamie, Nakano Makiko, Nomiyama Tetsuo, Okuda Hirokazu, Okuda Masayuki, Omae Kazuyuki, Sakurai Haruhiko, Sato Kazuhiro, Sobue Tomotaka, Suwazono Yasushi, Takebayashi Toru, Takeshita Tatsuya, Takeuchi Akito, Takeuchi Ayano, Tanaka Masatoshi, Tanaka Shigeru, Tsukahara Teruomi, Tsunoda Masashi, Ueno Susumu, Ueyama Jun, Umeda Yumi, Yamamoto Kenya, Yamano Yuko, Yamauchi Takenori, Yano Eiji

    JOURNAL OF OCCUPATIONAL HEALTH   Vol. 60 ( 4 ) page: 333 - 335   2018.7

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    DOI: 10.1539/joh.2018-0137-OP

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  44. Common variant of BCAS3 is associated with gout risk in Japanese population: the first replication study after gout GWAS in Han Chinese

    Sakiyama Masayuki, Matsuo Hirotaka, Nakaoka Hirofumi, Kawamura Yusuke, Kawaguchi Makoto, Higashino Toshihide, Nakayama Akiyoshi, Akashi Airi, Ueyama Jun, Kondo Takaaki, Wakai Kenji, Sakurai Yutaka, Yamamoto Ken, Ooyama Hiroshi, Shinomiya Nariyoshi

    BMC MEDICAL GENETICS   Vol. 19 ( 1 ) page: 96   2018.6

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    DOI: 10.1186/s12881-018-0583-z

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  45. Effects of processing and cooking on the reduction of dinotefuran concentration in Japanese rice samples.

    Watanabe M, Ueyama J, Ueno E, Ueda Y, Oda M, Umemura Y, Tanahashi T, Ikai Y, Saito I

    Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment     2018.3

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    DOI: 10.1080/19440049.2018.1451659

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  46. Oxidized human serum albumin as a possible correlation factor for atherosclerosis in a rural Japanese population: the results of the Yakumo Study

    Fujii Ryosuke, Ueyama Jun, Aoi Arisa, Ichino Naohiro, Osakabe Keisuke, Sugimoto Keiko, Suzuki Koji, Hamajima Nobuyuki, Wakai Kenji, Kondo Takaaki

    ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE   Vol. 23 ( 1 ) page: 1   2018.1

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    DOI: 10.1186/s12199-017-0690-z

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  47. Human Biomonitoring as a Useful Approach to Health Risk Assessment Compared with Occupational Exposure Assessment of Insecticide Intake: Fundamental Study Focused on Local Populations and Occupational Fields Invited Reviewed

    Jun Ueyama

    Nihon Eiseigaku Zasshi   Vol. 73 ( 3 ) page: 247 - 256   2018

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    DOI: 10.1265/jjh.73.247

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  48. (-)-Epigallocatechin-3-gallate Down-regulates Doxorubicin-induced Overexpression of P-glycoprotein Through the Coordinate Inhibition of PI3K/Akt and MEK/ERK Signaling Pathways. Reviewed

    HANA SATONAKA, KUMIKI ISHIDA, MIHO TAKAI, RYOJI KOIDE, RYOTA SHIGEMASA, JUN UEYAMA, TETSUYA ISHIKAWA, KAZUHIKO HAYASHI, HIDEMI GOTO and SHINYA WAKUSAWA

    Anticancer Res   Vol. 37 ( 11 ) page: 6071-6077   2017.11

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    DOI: 10.21873/anticanres.12055

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  49. Nitric Oxide Plasma Level as a Barometer of Endothelial Dysfunction in Factory Workers

    Miyata Seiko, Noda Akiko, Hara Yuki, Ueyama Jun, Kitaichi Kiyoyuki, Kondo Takaaki, Koike Yasuo

    EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES   Vol. 125 ( 10 ) page: 684 - 689   2017.11

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    DOI: 10.1055/s-0043-110054

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  50. Association Between Organophosphate Pesticide Exposure and Thyroid Hormones in Pregnant Women. Reviewed

    Yiwen Wang; Limei Chen; Caifeng Wang; Yi Hum; Yu Gao; Yijun Zhou; Rong Shi; Yan Zhang; Michihiro Kamijima; Jun Ueyama; Ying Tian

    Epidemiology   Vol. 2017 ( 28 ) page: S35–S40   2017.10

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    DOI: 10.1097/EDE.0000000000000721

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  51. Prenatal and postnatal exposure to organophosphate pesticides and childhood neurodevelopment in Shandong, China Reviewed

    Yiwen Wang, Yan Zhang, Lin Ji, YiHu, Jingjing Zhang, Caifeng Wang, Guodong Ding, Limei Chen, Michihiro Kamijima, Jun Ueyama, Yu Gao c, Ying Tian

    Environment International   Vol. 108   page: 119-126   2017.8

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    DOI: 10.1016/j.envint.2017.08.010

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  52. Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate and propyleneimine, and classifications on carcinogenicity, occupational sensitizer and reproductive toxicant. Invited Reviewed

    Kenichi Azuma, Ginji Endo, Yoko Endo, Tetsuhito Fukushima, Kunio Hara, Hajime Hori, Seichi Horie, Hyogo Horiguchi, Masayoshi Ichiba, Gaku Ichihara, Masayuki Ikeda, Tatsuya Ishitake, Akiyoshi Ito, Yuki Ito, Satoko Iwasawa, Michihiro Kamijima, Kanae Karita, Takahiko Katoh, Toshio Kawai, Toshihiro Kawamoto, Reiko Kishi, Shinji Kumagai, Yukinori Kusaka, Akiko Matsumoto, Muneyuki Miyagawa, Hiroyuki Miyauchi, Yasuo Morimoto, Kasuke Nagano, Hisao Naito, Tamie Nakajima, Tetsuo Nomiyama, Hirokazu Okuda, Kazuyuki Omae, Haruhiko Sakurai, Kazuhiro Sato, Tomotaka Sobue, Yasushi Suwazono, Toru Takebayashi, Tatsuya Takeshita, Akito Takeuchi, Ayano Takeuchi, Masatoshi Tanaka, Shigeru Tanaka, Teruomi Tsukahara, Masashi Tsunoda, Susumu Ueno, Jun Ueyama, Yumi Umeda, Yuko Yamano, Takenori Yamauchi and Eiji Yano

    J Occup Health   Vol. 59 ( 4 ) page: 364-366   2017.6

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    DOI: 10.1539/joh.17-0148-OP

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  53. Quantitative analysis of organophosphate insecticide metabolites in urine extracted from disposable diapers of toddlers in Japan. Reviewed

    NaokoOya, Yuki Ito, Keisuke Hioki, Yuya Asai, Arisa Aoi, Yuka Sugiura, Jun Ueyama, Tomoko Oguri, Sayaka Kato, Takeshi Ebara, Michihiro Kamijima

    International Journal of Hygiene and Environmental Health   Vol. 220 ( 2 ) page: 209 - 216   2017.3

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    DOI: 10.1016/j.ijheh.2016.10.009

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  54. Modulation of immunological activity on macrophages induced by diazinon. Reviewed

    Nanako Ogasawara, Miyoko Matsushima, Nami Kawamura, Kazuko Atsumi, Takehiro Yamaguchi, Haruka Ochi, Yuto Kusatsugu, Sayaka Oyabu, Naozumi Hashimoto, Yoshinori Hasegawa, Jun Ueyama, Tsutomu Kawabe

    Toxicology   Vol. 379   page: 22-30   2017.1

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    DOI: 10.1016/j.tox.2017.01.014

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  55. Exposure characterization of three major insecticide lines in urine of young children in Japan-neonicotinoids, organophosphates, and pyrethroids. Reviewed

    Osaka A, Ueyama J, Kondo T, Nomura H, Sugiura Y, Saito I, Nakane K, Takaishi A, Ogi H, Wakusawa S, Ito Y, Kamijima M.

    Environmental Research   Vol. 147   page: 89-96   2016.5

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    DOI: 10.1016/j.envres.2016.01.028.

  56. Temporal Levels of Urinary Neonicotinoid and Diaklyphosphate Concentrations in Japanese Women Between 1994-2011 Reviewed

    Jun Ueyama, Kouji H Harada, Akio Koizumi, Yuka Sugiura, Takaaki Kondo, Isao Saito, and Michihiro Kamijima

    Environmental Science & Tachinology   Vol. 49 ( 24 ) page: 14522-14528   2015.12

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    DOI: 10.1021/acs.est.5b03062

  57. Effects of Paraoxonase 1 gene polymorphisms on organophosphate insecticide metabolism in Japanese pest control workers. Reviewed

    Sato H, Ito Y, Ueyama J, Kano Y, Arakawa T, Gotoh M, Kondo T, Sugiura Y, Saito I, Shibata E, Kamijima M.

    Journal of Occupational Health   Vol. 58 ( 1 ) page: 56-65   2015.12

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    DOI: 10.1539/joh.15-0175-OA.

  58. Lack of contribution of multidrug resistance-associated protein and organic anion-transporting polypeptide to pharmacokinetics of Regorafenib, a novel multi-kinase inhibitor, in rats. Reviewed

    HOTTA Kazuo, UEYAMA Jun, TATSUMI Yasuaki, YSUKIYAMA Ikuto, SUGIURA Yuka, SAITO Hiroko, MATSUURA Katsuhiko, HASEGAWA Takaaki

    Anticancer Res   Vol. 35 ( 9 ) page: 4681-4689   2015.9

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    PubMedID:26254357

  59. Comparison of different urine pretreatments for biological monitoring of pyrethroid insecticides. Reviewed

    TOSHIMA Hiroki, YOSHINAGA Jun, SHIRAISHI Hiroaki, ITO Yuki, KAMIJIMA Michihiro, UEYAMA Jun

    Journal of Analytical Toxicology   Vol. 39 ( 2 ) page: 133-136   2015.3

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    DOI: 10.1093/jat/bku142

  60. Biological Monitoring Method for Urinary Neonicotinoid Insecticides Using LC-MS/MS and Its Application to Japanese Adults. Reviewed

    UEYAMA Jun, NOMURA Hiroshi, KONDO Takaaki, SAITO Isao, ITO Yuki, OSAKA Aya, KAMIJIMA Michihiro

    Journal of Occupational Health   Vol. 56   page: 461-468   2015.1

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    DOI: 10.1539/joh.14-0077-OA

  61. A revised method for determination of dialkylphosphate levels in human urine by solid-phase extraction and liquid chromatography with tandem mass spectrometry: application to human urine samples from Japanese children. Reviewed

    UEYAMA Jun, SAITO Isao, TAKAISHI Akiko, NOMURA Hiroshi, NOUE Mai, OSAKA Aya, SUGIURA Yuka, HAYASHI Yumi, WAKUSAWA Shinya, OGI Hiroko, INUZUKA Kimio, KAMIJIMA Michihiro, KONDO Takaaki

    Environmental Health and Preventive Medicine   Vol. 19 ( 6 ) page: 405-413   2014.11

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    DOI: 10.1007/s12199-014-0407-5.

  62. Contribution of plasma proteins, albumin and alpha 1-acid glycoprotein, to pharmacokinetics of a multi-targeted receptor tyrosine kinase inhibitor, sunitinib, in analbuminemic rats. Reviewed

    TOYAMA Yukio, UEYAMA Jun, NOMURA Hiroshi, TSUKIYAMA Ikuto, SAITO Hiroko, HISADA Tatsuya, MATSUURA Katsuhiko, HASEGAWA Takaaki

    Anticancer Res   Vol. 34 ( 5 ) page: 2283-2289   2014.6

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    PubMedID: 24778032

  63. A non-invasive biomonitoring method for assessing levels of urinary pyrethroid metabolites in diapered children by gas chromatography-mass spectrometry. Reviewed

    SAITO Shun, UEYAMA Jun, KONDO Takaaki, SAITO Isao, SHIBATA Eiji, GOTOH Masahiro, NOMURA Hiroshi, WAKUSAWA Shinya, NAKAI Kunihiko, KAMIJIMA Michihiro.

    J Expo Sci Environ Epidemiol   Vol. 24 ( 2 ) page: 200-7   2014.3

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    DOI: 23756699

  64. A revised method for determination of serum mercaptalbumin and nonmercaptalbumin by high performance liquid chromatography coupled with post-column bromocresol green reaction. Reviewed

    UEYAMA Jun, ISHIKAWA Yusuke, KONDO Takaaki, MOTOYAMA Megumi, MATSUMOTO Hiroyuki, MATSUSHITA Tadashi

    Ann Clin Biochem.   Vol. in press   page: in press   2014.3

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    DOI: in press

  65. Biochemical staging of the chronic hepatic lesions of Wilson disease. Reviewed

    Katano Y, Hayashi K, Hattori A, Tatsumi Y, Ueyama J, Wakusawa S, Yano M, Toyoda H, Kumada T, Mizutani N, Hayashi H, Goto H.

    Nagoya J Med Sci.   Vol. 76 ( 1-2 ) page: 139-148   2014.2

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  66. Ursodeoxycholic acid inhibits overexpression of P-glycoprotein induced by doxorubicin in HepG2 cells. Reviewed

    Komori Y, Arisawa S, Takai M, Yokoyama K, Honda M, Hayashi K, Ishigami M, Katano Y, Goto H, Ueyama J, Ishikawa T, Wakusawa S.

    Eur J Pharmacol.   Vol. 724   page: 161-167   2014.2

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    DOI: 10.1016/j.ejphar.2013.12.023.

  67. Quantitation of neonicotinoid metabolites in human urine using GC-MS. Reviewed

    NOMURA Hiroshi, UEYAMA Jun, KONDO Takaaki, SAITO Isao, MURATA Katsuyuki, IWATA Toyoto, WAKUSAWA Shinya, KAMIJIMA Michihiro

    Journal of Chromatography B   Vol. 941   page: 109-115   2013.12

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    DOI: 10.1016/j.jchromb.2013.10.012.

  68. Drug interaction between sunitinib and cimetidine and contribution of the efflux transporter ATP-binding cassette C2 to biliary excretion of sunitinib in rats. Reviewed

    ARAKAWA-TODO Mika, UEYAMA Jun, NOMURA Hiroshi, ABE Fumie, TSUKIYAMA Ikuto, MATSUURA Katsuhiko, HASEGAWA Takaaki

    Anticancer Research   Vol. 33 ( 8 ) page: 3089-3097   2013.8

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    DOI: 308-3097

  69. Preparation of dealcholized onetaxotere®, docetaxel injection formulation and its pharmacokinetics in rats. Reviewed

    Onishi Katsuhiro, TSUKIYAMA Ikuto, UEYAMA Jun, ABE Fumie, SAITO Hiroko, MATSUURA Katsuhiko, NADAI Masayuki, HASEGAWA Takaaki

    Gan To Kagaku Ryoho.   Vol. 40 ( 7 ) page: 891-986   2013.7

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  70. Various copper and iron overload patterns in the livers of patients with Wilson disease and idiopathic copper toxicosis Reviewed

    HAYASHI Hisao, HATTORI Ai, TATSUMI Yasuaki, HAYASHI Kazuhiko, KATANO Yoshiaki, UEYAMA Jun, WAKUSAWA Shinya, YANO Motoyoshi, GOTO Hidemi

    Med Mol Morphol.   Vol. 22   page: 00-00   2013.1

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  71. Evidence for diazinon-mediated inhibition of cis-permethrin metabolism and its effects on reproductive toxicity in adult male mice Reviewed

    WANG Dong, KAMIJIMA Michihiro, OKAMURA Ai, ITO Yuki, YANAGIBA Yukie, JIA Xiao-fang, NAITO Hisao, UEYAMA Jun, NAKAJIMA Tamie

    Reprod Toxicol.   Vol. 34   page: 489-497   2012.12

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  72. Urinary concentrations of organophosphorus insecticide metabolites in Japanese workers Reviewed

    UEYAMA Jun, SAITO Isao, KONDO Takaaki, TAKI Tomoko, KIMATA Akiko, SAITO Shun, ITO Yuki, MURATA Katsuyuki, IWATA Toyoto, GOTOH Masahiro, SHIBATA Eiji, WAKUSAWA Shinya, KAMIJIMA Michihiro

    Chemosphere   Vol. 87   page: 1403-1409   2012.6

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  73. Prevalence of Helicobacter Pylori Infection Measured with Urinary Antibody in an Urban Area of Japan, 2008-2010 Reviewed

    TAMURA Takashi, MORITA Emi, KONDO Takaaki, UEYAMA Jun, TANAKA Tetsuya, KIDA Yuto, HORI Yoko, INOUE Shigeru, TOMITA Koutaro, OKADA Rieko, KAWAI Sayo, HISHIDA Asahi, NAITO Mariko, WAKAI Kenji and HAMAJIMA Nobuyuki

    Nagoya Journal of Medical Science   Vol. 74   page: 63-70   2012.2

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  74. New analytical method for sensitive quantification of urinary 3-methyl-4-nitrophenol to assess fenitrothion exposure in general population and occupational sprayers Reviewed

    OKAMURA Ai, SAITO Isao, UEYAMA Jun, ITO Yuki, NAKAJIMA Tamie, KAMIJIMA Michihiro

    Toxicol Lett.   Vol. 210 ( 2 ) page: 220-224   2011.11

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  75. Panipenem does not alter the pharmacokinetics of the active metabolite of irinotecan SN-38 and inactive metabolite SN-38 glucuronide (SN-38G) in rats Reviewed

    KATO Ayako, UEYAMA Jun, ABE Fumie, HOTTA Kazuo, TSUKIYAMA Ikuo, OSHIMA Taeyuki, KONDO F, SAITO Hiroko, HASEGAWA Takaaki.

    Anticancer Res.   Vol. 31 ( 9 ) page: 2915-2922   2011.9

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    PubMed ID21868538
    The present study has investigated the effect of panipenem, a widely used antibiotic, on the pharmacokinetics of an active metabolite of irinotecan (CPT-11), 7-ethyl-10-hydroxy-camptothecin (SN-38) and SN-38 glucuronide (SN-38G) produced by uridine-diphosphate glucuronosyltransferase (UGT) 1A isoform-mediated glucuronidation in rats. Rats received a 1 h infusion with panipenem at a loading dose of 10 mg/kg and a maintenance dose of 15 mg/min/kg once a day for 5 days. When the effect of pretreatment with panipenem on glucuronidation activities of substrates for hepatic UGT1A isoforms was investigated using substrates 4-methylumbelliferone (4MU), estradiol and SN-38, the rate of 4MU glucuronide formation was significantly increased, but that of estradiol glucuronide formation was unchanged. However, the rate of SN-38G formation showed a tendency to increase. One hour after the final infusion of panipenem or saline, SN-38 (2 mg/kg) was administered intravenously in rats with or without bile duct cannulation. Pretreatment with panipenem had no effect on the plasma concentration-time curves and biliary excretion of SN-38 and SN-38G in rats with and without bile duct cannulation. There were also no significant differences in the relative extent of glucuronidation of SN-38 to SN-38G (AUC(2 h, SN-38G)/AUC(2 h, SN-38)) between panipenem-treated and untreated rats. These findings suggest that pretreatment with panipenem does not alter the pharmacokinetics of SN-38 and SN-38G, suggesting the possibility that panipenem can be used safely for cancer patients undergoing irinotecan chemotherapy.

  76. Study Profile on Baseline Survey of Daiko Study in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study) Reviewed

    MORITA Emi, HAMAJIMA Nobuyuki, HISHIDA Asahi, AOYAMA Kyoko, OKADA Rieko, KAWAI Sayo, TOMITA Koutaro, KURIKI Sayaka, TAMURA Takashi, NAITO Mariko, KONDO Takaaki, UEYAMA Jun, KIMATA Akiko, YAMAMOTO Kanami, HORI Yoko, HOSHINO Junko, HAMAMOTO Ritsuko, TSUKAMOTO Sanae, ONISHI Johji, HAGIKURA Shoichi, NAITO Hisao, HIBI Satoshi, ITO Yoshinori and WAKAI Kenji

    Nagoya Journal of Medical Science   Vol. 73   page: 187-195   2011.8

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  77. Effect of DDVP on urinary excretion levels of pyrethroid metabolite 3-phenoxybenzoic acid in rats Reviewed

    HIROSAWA Naoko, UEYAMA Jun, KONDO Takaaki, KAMIJIMA Michihiro, TAKAGI Kenji, FUJINAKA Sanae, HIRATE Ayaka, HASEGAWA Takaaki, WAKUSAWA Shinya.

    Toxicol Lett.   Vol. 203 ( 1 ) page: 28-32   2011.4

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    PubMed ID:21471973
    Pyrethroid insecticide (PYR) is used worldwide in agriculture and for indoor extermination of harmful insects. Urinary PYR metabolites (e.g. 3-phenoxybenzoic acid, 3PBA) have been used as the most sensitive biomarker for environmental PYR exposure since the late 1990's. In this study, we examined the effect of organophosphorus insecticide (OP) dichlorvos (DDVP) on excretion levels of urinary cis-permethrin-derived 3PBA in rats. Concentration of urinary 3PBA and cis-permethrin in plasma were monitored using gas chromatography-mass spectrometry and high-performance liquid chromatography after cis-permethrin injection (20mg/kg) via the tail vein of rats pretreatmented intraperitoneally with DDVP (low dose, 0.3mg/kg; high dose, 1.5mg/kg). The amount of urinary 3PBA excretion over 48h after cis-permethrin administration in control was 21.5±5.1μg (mean±S.D.). In the low- and high-dose DDVP groups, the amounts of urinary 3PBA excretion were decreased to 81.1% (17.4±2.7μg) and 70.3% (15.1±2.6μg) of control, respectively. The plasma concentrations of cis-permethrin-derived 3-phenoxybenzyl alcohol (3PBAlc), which is a metabolite derived following hydrolysis of cis-permethrin, in high-dose DDVP group (0.18±0.01μg) were significantly lower than in control (0.23±0.03μg) 1h after cis-permethrin injection. Both in the control and high-dose DDVP group, no differences were observed in the excretion levels of urinary 3PBA after injection of 3PBAlc (25mg/kg, i.v). These results suggested that the effect of DDVP on the amount of urinary 3PBA excretion was caused by the DDVP-induced modification of the cis-permethrin metabolic pathway. In conclusion, the possible decrease in urinary excretion level of 3PBA due to co-exposure to OPs should be considered in the biological monitoring of PYR exposure.

  78. Mechanism underlying the efficacy of combination therapy with losartan and hydrochlorothiazide in rats with salt-sensitive hypertension. Reviewed

    YAMADA Yuichiro, TSUBOI Koji, HATTORI Takuya, MURATE Takashi, OHTAKE Masafumi, FRUKAWA Mayuko, UEYAMA Jun, NISHIYAMA Akira, MUROHARA Toyoaki, NAGATA Kohzo.

    Hypertens Res   Vol. 34 ( 7 ) page: 809-816   2011.4

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    PubMed ID21471973
    Although thiazide diuretics are commonly used to supplement angiotensin receptor blockers for treatment of hypertension, the mechanism underlying the therapeutic effects of this drug combination remains unclear. We investigated the antihypertensive and cardioprotective effects of combination therapy with losartan (LOS) and hydrochlorothiazide (HCTZ), in comparison with those of either drug alone, in Dahl salt-sensitive hypertensive rats. Rats fed a high-salt diet from 6 weeks of age were treated with LOS, HCTZ, both drugs (COMB) and vehicle from 6 to 11 weeks. The salt-induced increase in systolic blood pressure was attenuated moderately by LOS and to a greater extent by HCTZ and COMB. Left ventricular (LV) hypertrophy and fibrosis, diastolic dysfunction, as well as angiotensin-converting enzyme and angiotensin II type 1A (AT(1A)) receptor gene expression were attenuated similarly by LOS and HCTZ and more so by COMB. LOS downregulated expression of the AT(1A) receptor gene, without affecting that of the AT(2) receptor gene, in the aorta. In contrast, neither HCTZ nor COMB affected aortic expression of the AT(1A) receptor gene, but both markedly upregulated that of the AT(2) receptor gene. The salt-induced decrease in the plasma concentration of nitric oxide metabolites was attenuated substantially by LOS and abolished by both HCTZ and COMB. In conclusion, the combination of LOS and HCTZ attenuated hypertension, as well as LV remodeling and diastolic dysfunction, more effectively than did LOS or HCTZ alone in rats with salt-sensitive hypertension. Modulation of the cardiac and vascular renin-angiotensin system may have contributed to these beneficial effects of the drug combination.

  79. Association of UGT1A1 Gly71Arg with urine urobilinogen Reviewed

    KATAOKA Ryuji, KIMATA Akiko, YAMAMOTO Kanami, HIROSAWA Naoko, UEYAMA Jun, KONDO Takaaki, OKADA Rieko, KAWAI Sayo, HISHIDA Asahi, NAITO Mariko, MORITA Emi, WAKITA Kenji, HAMAJIMA Nobuyuki

    Nagoya Journal of Medical Science   Vol. 73 ( 1-2 ) page: 33-40   2011.4

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    PubMed ID:21614935

  80. Involvement of sulfate conjugation and multidrug resistance-associated protein 2 (MRP2) in sex-related differences in the pharmacokinetics of garenoxacin in rats Reviewed

    HAYASHI Tamon, ABE Fumie, KATO Miki, SAITO Hiroko, UEYAMA Jun, KONDO Yuya, IMAI Kuniyuki, KATOH Miki, NADAI Masayuki, HASEGAWA Takaaki

    J Infect Chemother   Vol. 17 ( 1 ) page: 24-29   2011.2

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    PubMed ID:20676911

  81. Beta-glucuronidase activity is a more sensitive biomarker than cholinesterase inhibition for organophosphorus insecticide exposure Reviewed

    UEYAMA Jun, SATOH Tetsuo, KONDO Takaaki, TAKAGI Kenji, SHIBATA Eiji, GOTO Masahiro, KIMATA Akiko, SAITO Isao, HASEGAWA Takaaki, WAKUSAWA Shinya, KAMIJIMA Michihiro.

    Toxicol Lett   Vol. 193 ( 1 ) page: 115-119   2010.12

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    PubMed ID:20026393

  82. Endotoxin does not alter the pharmacokinetics of micafungin,but it impairs biliary excretion of micafungin via multidrugresistance-associated protein 2 (ABCC2/Mrp2) in rats Reviewed

    NODA Takayuki, ABE Fumie, UEYAMA Jun, KATO Miki, KATOH Miki, NADAI Masayuki, SAITO Hiroko, HASEGAWA Takaaki

    J Infect Chemother     2010.9

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    PubMed ID:20835743
    Micafungin, a newly developed echinocandin-type antifungal agent, is widely used for the treatment of deep-seated fungal infections including those of Candida species and Aspergillus species. In the present study, the possible alterations in the pharmacokinetics and biliary excretion of micafungin were investigated in endotoxemic rats induced by Klebsiella pneumoniae endotoxin. Endotoxin (2 mg/kg) was injected intraperitoneally 24 h before an intravenous injection of micafungin (1 mg/kg). No significant differences in the plasma concentration-time curves and pharmacokinetic parameters of micafungin were observed between endotoxin-treated and endotoxin-untreated rats. When endotoxin-treated rats received a constant-rate infusion of micafungin, the biliary clearance of micafungin was significantly decreased, whereas the steady-state plasma concentration did not change. By protein immunoblot analysis, a significant decrease in the expression of hepatic multidrug resistance-associated protein 2 (ABCC2/Mrp2), which is an efflux protein for micafungin, was observed in endotoxin-treated rats. These results suggest that endotoxin-induced decrease in the hepatobiliary excretion of micafungin is caused, at least in part, by the reduction of Mrp2-mediated hepatobiliary transport ability. The present study may provide information suggesting that micafungin can be used for patients with endotoxemia without the need for dosage adjustment.

    DOI: 10.1007/s10156-010-0118-9

  83. Preliminary study on spontaneous hepatitis in long-evans cinnamon rats: a blood echange may improve the fetal hepatitis Reviewed

    UEYAMA Jun, WAKUSAWA Shinya, TATSUMI Yasuyuki, HATTOEI Ai, YANO Motoyoshi, HAYASHI Hisao

    Nagoya J Med Sci   Vol. 72 ( 3-4 ) page: 173-177   2010.8

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    PubMed ID:20942273

  84. Toxicokinetics of pyrethroid metabolites in male and female rats Reviewed

    UEYAMA Jun, HIROSAWA Naoko, MOCHIZUKI Aiko, KIMATA Akiko, KAMIJIMA Michihiro, KONDO Takaaki, TAKAGI Kenji, WAKUSAWA Shinya, HASEGAWA Takaaki

    Environmental Toxicology and Pharmacology   Vol. 30 ( 1 ) page: 88-91   2010.7

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    DOI: 10.1016/j.etap.2010.03.017

  85. Revised method for routine determination of urinary dialkyl phosphates using gas chromatography-mass spectrometry Invited Reviewed

    UEYAMA Jun, KAMIJIMA Michihiro, KONDO Takaaki, TAKAGI Kenji, SHIBATA Eiji, HASEGAWA Takaaki, WAKUSAWA Shinya, TAKI Tomoko, GOTO Masahiro, SAITO Isao

    J Chromatogra B   Vol. 878 ( 17-18 ) page: 1257-1263   2010.5

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    PubMed ID:20207202

  86. Analysis and evaluation of pyrethroid exposure in human population based on biological monitoring of urinary pyrethroid metabolites Reviewed

    UEYAMA Jun, SAITO Isao, KAMIJIMA Michihiro

    Journal of Pesticide Science   Vol. 35 ( 2 ) page: 87-98   2010.4

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  87. 健常成人における成熟にんにくの血管内皮機能へ及ぼす影響 Reviewed

    宮田聖子、野田明子、永井万由佳、大嶽正文、上山純、古池保雄

    日本臨床生理学会雑誌   Vol. 40 ( 2 ) page: 103-108   2010.4

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  88. Measurement of forearm blood flow of healthy young men and women using strain-gauge plethysmography Reviewed

    KONDO Takaaki, YAMADA Chie, FURUTA Takako, YOSHITAKE Junko, SHIROTORI AYA, OKADA Yoshiko, KIMATA Akiko, YAMAMOTO Kanami, UEYAMA Jun, SAKAKIBARA Hisataka, FUKAYA Yukio

    Bull Aichi Bunkyo Women's Coll   Vol. 31   page: 27-34   2010.3

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  89. Comparison of urinary concentrations of 3-phenoxybenzoic acid among general residents in rural and suburban areas and employees of pest control firms Reviewed

    KIMATA Akiko, KONDO Takaaki, UEYAMA Jun, YAMAMOTO K, YOSHITAKE Junko, TAKAGI Kenji, SUZUKI Koji, INOUE Takashi, ITO Yoshinori, HAMAJIMA Nobuyuki, KAMIJIMA Michihiro, GOTOH Masahiro, SHIBATA Eiji.

    Int Arch Occup Environ Health   Vol. 82 ( 10 ) page: 1173-1178   2009.11

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  90. Broken sperm, cytoplasmic droplets and reduced sperm motility are principal markers of decreased sperm quality due to organophosphorus pesticides in rats Reviewed

    OKAMURA Ai, KAMIJIMA Michihiro, OHTANI Katsumi, YAMANOSHITA Osamu, NAKAMURA Daichi, ITO Yuki, MIYATA Maiko, UEYAMA Jun, SUZUKI Takayoshi, IMAI Ryota, TAKAGI Kenji, NAKAJIMA Tamie.

    J Occup Health   Vol. 51 ( 6 ) page: 478-487   2009.9

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  91. Relationship between dietary habits and urinary concentrations of 3-phenoxybonzoic acid in a middle-aged and elderly general population in Japan Reviewed

    KIMATA Akiko, KONDO Takaaki, UEYAMA Jun, YAMAMOTO Kanami, KAMIJIMA Michihiro, SUZUKI Koji INOUE Takashi, ITO Yoshinori, HAMAJIMA Nobuyuki.

    Environ Health Prev Med   Vol. 14 ( 3 ) page: 173-179   2009.5

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  92. Possible involvement of interleukin-6 (IL-6) in down-regulation of hepatic breast cancer resistance protein (Bcrp/ABCG2) in endotoxemic mice Reviewed

    ZHAO Ying Lan, CEN X, ABE Fumie, UEYAMA Jun, HOTTA K, KATO S, ITO S, SAGA S, FUKAYA Yukio, WANG L, WEI Y, HASEGAWA Takaaki

    Bull Aichi Bunkyo Women's Coll   Vol. 30   page: 27-42   2009.3

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  93. Multilevel analyses of effects of variation in body mass index on serum lipid concentrations in middle-aged Japanese men Reviewed

    KONDO Takaaki, KIMATA Akiko, YAMAMOTO Kanami, UEYAMA Sayoko, UEYAMA Jun, Yatsuya H, TAMAKOSHI K, HORI Yoko

    Nagoya J Med Sci.   Vol. 71 ( 1-2 ) page: 19-28   2009.2

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  94. Urinary excretion of 3-phenoxybenzoic acid in middle-aged and elderly general population of Japan Reviewed

    UEYAMA Jun, KIMATA Akiko, KAMIJIMA Michihiro, HAMAJIMA Nobuyuki, ITO Yuki, SUZUKI Koji, INOUE Takashi, YAMAMOTO Kanami, TAKAGI Kenji, SAITO Isao, MIYAMOTO K, HASEGAWA Takaaki, KONDO Takaaki

    Environ Res   Vol. 109 ( 2 ) page: 175-180   2009.2

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    Limited data are available on the background levels of exposure to synthetic pyrethroid (PYR) in Japan, despite their frequent application for agriculture and indoor extermination and possible effects of chronic and/or low-dose PYR exposure on human health. This study was conducted to describe the level and distribution of one of the major PYR metabolites, 3-phenoxybenzoic acid (3-PBA), in urine samples collected from a general population in Japan. The subjects were 535 individuals (184 men and 351 women; 61.5+/-9.8 years of age, mean+/-S.D.) residing in a town in Hokkaido, a dairy and agricultural area. Urinary 3-PBA was found detectable in 98% of samples above the limit of detection of 0.02 microg/l. The geometric mean values of urinary 3-PBA in occupationally exposed farmers (n=87) and the remaining general group without occupational exposure (n=448) were 0.38 and 0.29 microg/l, respectively, ranging from <LOD to 17.09 microg/l. No significant differences in urinary 3-PBA concentrations were shown between these two groups. Moreover, 3-PBA concentrations were found comparable to those reported in some countries. The present study is, to our knowledge, the first report of a biological monitoring study of urinary 3-PBA, which elucidated the background environmental exposure level of PYR in the Japanese general population without occupational exposure. Further nationwide studies covering different seasons and age distribution are needed to monitor the urinary 3-PBA levels in Japan.

  95. Effects of short-term variation in body mass index on blood pressure in middle-aged Japanese male workers. Reviewed

    KONDO Takaaki, KIMATA Akiko, YAMAMOTO Kanami, UEYAMA Sayoko, UEYAMA Jun, HORI Yoko

    J Health Sci   Vol. 55 ( 1 ) page: 62-71   2009.2

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  96. Use of waist circumference and ultrasonographic assessment of abdominal fat distribution in predicting metabolic risk factors in healthy Japanese adults Reviewed

    KONDO Takaaki, ABE Maimi, UEYAMA Jun, KIMATA Akiko, YAMAMOTO Kanami, HORI Yoko.

    J Physiol Anthropo   Vol. 28 ( 1 ) page: 7-14   2009.1

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  97. Relationship between urinary pesticide metabolites and pest control operation among occupational pesticide sprayers Reviewed

    KIMATA Akiko, KONDO Takaaki, UEYAMA Jun, YAMAMOTO Kanami, KAMIJIMA Michihiro, SUZUKI Koji, INOUE Takashi, ITO Yuki, HAMAJIMA Nobuyuki.

    J Occup Health   Vol. 51 ( 1 ) page: 100-105   2009.1

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  98. Ursodeoxycholic acid induces glutathione synthesis through activation of PI3K/Akt pathway in HepG2 cells Reviewed

    ARISAWA Sakiko, ISHIDA Kumiki, KAMEYAMA Natsumi, UEYAMA Jun, HATTORI Ai, TATSUMI Yasuaki, HAYASHI Hisao, YANO Motoyoshi, HAYASHI Kazuhiko, KATANO Yoshiaki, GOTO Hidemi, TAKAGI Kenji, WAKUSAWA Shinya

    Biochem Pharmacol   Vol. 77 ( 5 ) page: 858-866   2009.1

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  99. Effect of the organophosphorus pesticide diazinon on glucose tolerance in type 2 diabetic rats Reviewed

    UEYAMA Jun, KAMIJIMA Michihiro, ASAI Kazumi, MOCHIZUKI Aiko, WANG Dong, KONDO Takaaki, SUZUKI Takayuki, TAKAGI Kenji, TAKAGI Kenji, KANAZAWA Hiroaki, MIYAMOTO Ken-ichi, WAKUSAWA Shinya, HASEGAWA Takaaki.

    Toxicol Lett   Vol. 182 ( 1-3 ) page: 42-47   2008.11

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    DZN deteriorates the glucose tolerance in GK rats. It is unlikely that this phenomenon is due to differences in ChE activity and/or DZN-oxon production levels between Wistar and GK rats.

  100. Role of plasma proteins in pharmacokinetics of micafungin, an antifungal antibiotic, in analbuminemic rats Reviewed

    ABE Fumie, UEYAMA Jun, KAWASUMI Noriyo, NADAI Masayuki, HAYASHI Tamon, KATO Miki, OHNISHI Masafumi, SAITO Hiroko, TAKEYAMA Naoshi, HASEGAWA Takaaki.

    Antimicrob Agents Chemother   Vol. 52 ( 9 ) page: 3454-3456   2008.9

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  101. Involvement of multidrug resistance-associated protein 2 (ABCC2/Mrp2) in biliary excretion of micafungin in rats Reviewed

    ABE Fumie, UEYAMA Jun, KIMATA Akiko, KATO Miki, Hayashi T, NADAI Masayuki, SAITO Hiroko, TAKEYAMA Naoshi, NOGUCHI Hiroshi, HASEGAWA Takaaki.

    Life Sci   Vol. 83 ( 7-8 ) page: 229-235   2008.8

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  102. Effect of thalidomide on endotoxin-induced decreases in activity and expression of hepatic cytochrome P450 3A2 Reviewed

    UEYAMA Jun, NADAI Masayuki, ZHAO Ying Lan, KANAZAWA Hiroaki, TAKAGI Kenji, KONDO Takaaki, TAKAGI Kenzo, WAKUSAWA Shinya, ABE Fumie, SAITO Hiroko, MIYAMOTO K, HASEGAWA Takaaki.

    Biol Pharm Bull   Vol. 31 ( 8 ) page: 1596-1600   2008.8

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  103. Involvement of -pro-inflammatory mediators in endotoxin-induced overproduction of inducible nitric oxide synthase and decrease in expression of hepatic cytochrome P450 Reviewed

    UEYAMA Jun, WAKUSAWA Shinya, FUKAYA Yukio, HASEGAWA Takaaki.

    Bull Aichi Bunkyo Women's Coll   Vol. 29   page: 39-49   2008.3

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  104. Permethrin may induce adult male mouse reproductive toxicity due to cis isomer not trans isomer Reviewed

    ZHANG Shu-Yun, UEYAMA Jun, ITO Yuki, YANAGIBA Yukie, OKAMURA Ai, KAMIJIMA Michihiro, NAKAJIMA Tamie.

    Toxicology   Vol. 248 ( 2-3 ) page: 136-141   2008.3

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  105. Acute effect of exercise on blood pressure among fitness facility users, with special reference to influence of body mass index Reviewed

    KONDO Takaaki, UEYAMA Jun, KIMATA Akiko, YAMAMOTO K, FUKAYA Yukio.

    Bull Aichi Bunkyo Women's Coll   Vol. 29   page: 27-37   2008.3

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  106. Increase in P-glycoprotein accompanied by activation of protein kinase C alpha and NF-kappa B p65 in the livers of rats with streptozotocin-induced diabetes Reviewed

    KAMEYAMA Natsumi, ARISAWA Sakiko, UEYAMA Jun, KAGOTA Satomi, SHINOZUKA Kazumasa, HATTORI Ai, TATSUMI Yasuaki, HAYASHI Hisao, TAKAGI Kenji, WAKUSAWA Shinya

    Biochim Biophys Acta   Vol. 1782 ( 5 ) page: 355-360   2008.3

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  107. Association of serum NOx level with clustering of metabolic syndrome components in middle-aged and elderly general populations in Japan Reviewed

    UEYAMA Jun, KONDO Takaaki, IMAI Ryota, KIMATA Akiko, YAMAMOTO Kanami, SUZUKI Koji, INOUE Takashi, ITO Yoshinori, MIYAMOTO Ken-ichi, HASEGAWA Takaaki, HAMAJIMA Nobuyuki.

    Environ Health Prev Med   Vol. 13 ( 1 ) page: 36-42   2008.1

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    The results of ANCOVA confirmed that the serum lnNO( x ) level was significantly correlated with the clustering of MetS components in both men and women (p < 0.0001 for trend). CONCLUSION: Our results suggest that an increase in the clustering of MetS components was associated with the increase in serum NO levels in our general population.

  108. Association of glycemic profiles with whole blood polyamine among middle-aged Japanese men: colorimetric assay using oat and barley seedling polyamine oxidase Reviewed

    KONDO Takaaki, YAMAMOTO Kanami, KIMATA Akiko, UEYAMA Jun, HORI Yoko, TAKAGI Kenji.

    Environ Health Prev Med   Vol. 13 ( 1 ) page: 43-51   2008.1

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  109. Direct analysis of permethrins in human blood by SPE-GC/MS Reviewed

    OGATA-KAWATA H, MATSUDA M, ONDA N, UEYAMA Jun, KAMIJIMA Michihiro, SHIBATA Eiji, OGAWA M, ENDO Y.

    Chromatography   Vol. 28 ( 3 ) page: 119-124   2007.12

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  110. 健常成人男性で体重が血圧に与える影響 -経年的測定データの多重レベル解析- Reviewed

    近藤高明, 上山純, 木全明子, 山本佳那実, 堀容子.

    厚生の指標   Vol. 54 ( 13 ) page: 7-13   2007.11

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    職域集団の男性4,588名の1997年から2000年の健診受診データを用いて,血圧変動と体重変動との関連を多重レベルモデルにより解析した。BMIの変動は収縮期血圧,拡張期血圧とも有意に正の関連を示した。またその切片と傾きには個人間変動が有意に大きいことを明らかにした。

  111. Biological monitoring of pyrethroid exposure for pest control workers in Japan Reviewed

    WANG Dong, KAMIJIMA Michihiro, IMAI Ryota, SUZUKI Takayuki, KAMEDA Yohei, ASAI Kazumi, OKAMURA Ai, NAITO Hisao, UEYAMA Jun, SAITO Isao, NAKAJIMA Tamie, GOTO Masahiro, SHIBATA Eiji, KONDO Takaaki, TAKAGI Kenji, TAKAGI Kenzo, WAKUSAWA Shinya.

    J Occup Health   Vol. 49 ( 6 ) page: 509-514   2007.11

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  112. Lack of effect of aerobic physical exercise on endothelium-derived nitric oxide concentrations in healthy young subjects. Reviewed

    YAMAMOTO Kanami, KONDO Takaaki, KIMATA Akiko, UEYAMA Jun, SHIROTORI Aya, OKADA Yoshiko, SAKUI Daisuke, NAKASHIMA Masahiro, YAMADA Sumio

    Nagoya J Med Sci.   Vol. 69 ( 3-4 ) page: 167-172   2007.9

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  113. Permethrin may disrupt testosterone biosynthesis via mitochondrial membrane damage of Leydig cells in adult male mouse Reviewed

    ZHANG Shu-Yun, ITO Yuki, YAMANOSHITA Osamu, YANAGIBA Yukie, KOBAYASHI Miya, Taya Kazuyoshi, LI ChunMei, OKAMURA Ai, Miyata Maiko, UEYAMA Jun, LEE Chul-Ho, KAMIJIMA Michihiro, NAKAJIMA Tamie.

    Endocrinology   Vol. 148 ( 8 ) page: 3941-3949   2007.8

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  114. Association of a polymorphism in the ornithine decarboxylase gene with whole blood polyamine concentrations in a non-smoking healthy population Reviewed

    KONDO Takaaki, HAMAJIMA Nobuyuki, NISHIO Kazuko, ISHIDA Yoshiko, IMAI Ryota, UEYAMA Jun, TORITA Shoko, KASAI Yurie, YAMAMOTO Ryoko, SUZUKI Koji, ITO Yoshinori.

    J Health Sci   Vol. 53 ( 4 ) page: 406-412   2007.8

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  115. Toxicity of diazinon and its metabolites increases in diabetic rats Reviewed

    UEYAMA Jun, WANG Dong, KONDO Takaaki, SAITO Isao, TAKAGI Kenji, TAKAGI Kenzo, KAMIJIMA Michihiro, NAKAJIMA Tamie, MIYAMOTO K, WAKUSAWA Shinya, HASEGAWA Takaaki.

    Toxicol Lett   Vol. 170 ( 3 ) page: 229-237   2007.4

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  116. Lack of Effect of Aciclovir on Metabolism of Theophylline andExpression of Hepatic Cytochrome P450 1A2 in Rats Reviewed

    NADAI Masayuki, KATO Miki, YASUI Kazumasa, KIMURA Masao, ZHAO Ying Lan, UEYAMA Jun, TSUNEKAWA Yoshimi, YOSHIZUMI Hideo, HASEGAWA Takaaki.

    Biol Pharm Bull   Vol. 30 ( 3 ) page: 562-568   2007.3

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  117. Serial Variations in Serum Hepatic Profiles among Occupational Pesticide Sprayers: Multilevel Analyses of 14-Year Health Check-up Data Reviewed

    KONDO Takaaki, UEYAMA Jun, FUKAYA Yukio, GOTO Masahiro.

    Bull Aichi Bunkyo Women's Coll   Vol. 28   page: 1-7   2007.3

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  118. Involvement of nitric oxide (NO) in endotoxin-induced decrease in expression of hepatic cytochrome P450 Reviewed

    UEYAMA Jun, KONDO Takaaki, FUKAYA Yukio, HASEGAWA Takaaki.

    Bull Aichi Bunkyo Women's Coll   Vol. 28   page: 9-16   2007.3

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  119. 8-Hydroxydeoxyguanosine levels in human leukocyte and urine according to exposure to organophosphorus pesticides and paraoxonase 1 genotype Reviewed

    LEE Chul-Ho, KAMIJIMA Michihiro, KIM Heon, SHIBATA Eiji, UEYAMA Jun, SUZUKI Takayoshi, TAKAGI Kenji, SAITO Isao, GOTO Masahiro, HIBI Hattsuki, NAITO Hisao, NAKAJIMA Tamie.

    Int Arch Occup Environ Health   Vol. 80 ( 3 ) page: 217-227   2007.1

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  120. Association of abdominal circumference with serum nitric oxide concentration in healthy population Reviewed

    KONDO Takaaki, UEYAMA Jun, IMAI Ryota, SUZUKI Koji, ITO Yoshinori

    Environ Health Prev Med   Vol. 11 ( 6 ) page: 321-325   2006.12

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  121. Protein kinase Cbeta isoform down-regulates the expression of MDR3 P-glycoprotein in human Chang liver cells Reviewed

    SUZUKI Satoshi, HAYASHI Hisao, TAKAGI Kenji, KONDO Takaaki, TAKAGI Kenji, UEYAMA Jun, WAKUSAWA Shinya.

    Biochim Biophys Acta   Vol. 1760 ( 10 ) page: 1552-1557   2006.10

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  122. 健常成人集団での加齢と経年的血圧変動との関連性 -一般線形混合モデルの適用- Reviewed

    近藤高明、渡邊ゆかり、上山 純、堀 容子、八谷 寛、玉腰浩司、豊嶋英明.

    日循予防誌   Vol. 41 ( 2 ) page: 55-61   2006.10

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    職域での健常男性集団の4年間の健診データを用いて,肥満度と血圧との関連を明らかにするため多重レベル解析を実施した。BMIは収縮期血圧,拡張期血圧と有意な正の関連を示した。変量効果の推定値から,この直線関係での切片と傾きでは,個人間の変動が有意に大きいことも示した。

  123. 人工重力とエルゴメータ運動の併用により、無為臥床により惹起される心萎縮は防止可能である Reviewed

    岩瀬三紀, 武市康志, 石木良治, 稲垣春夫, 岩瀬 敏, 井澤英夫, 永田浩三, 上山 純, 加藤洋介, 野田明子, 古池保雄, 横田充弘.

    心臓   Vol. 38   page: 20-23   2006.4

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    慢性無為臥床による擬似低重力により惹起される心萎縮は、人工重力および律動運動の両者併用により防止可能であり、心臓不適応も軽減可能である。

  124. Simultaneous determination of urinary dialkyl phosphate metabolites of organophosphorus pesticides using gas chromatography-mass spectrometry Reviewed

    UEYAMA Jun, SAITO Isao, KAMIJIMA Michihiro, NAKAJIMA Tamie, GOTOH Masahiro, SUZUKI Takayuki, SHIBATA Eiji, KONDO Takaaki, TAKAGI Kenji, MIYAMOTO Ken-ichi, TAKAMATSU Junki, HASEGAWA Takaaki, TAKAGI Kenzo

    J Chromatogr B   Vol. 832   page: 58-66   2006.2

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    The present method, which does not require special equipment except for GC-MS, is quick, safe, and sensitive enough to be adopted in routine biological monitoring of non-occupational as well as occupational exposure to organophosphorus pesticides.

  125. A comprehensive evaluation of the testicular toxicity of dichlorvos in Wistar rats Reviewed

    OKAMURA Ai, KAMIJIMA Michihiro, SHIBATA Eiji, OHTANI Katsumi, TAKAGI Kenji, UEYAMA Jun, WATANABE Yukari, OMURA Minoru, WANG Hailan, ICHIHARA Gaku, KONDO Takaaki, NAKAJIMA Tamie.

    Toxicology   Vol. 213   page: 129-137   2005.9

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  126. 生活習慣病患者における血漿NOの検討 Reviewed

    宮田聖子, 野田明子, 安藤晃禎, 吉村敦子, 上山 純, 北市清幸, 黒木祥子, 助川真代, 古池保雄, 横田充弘.

    日本臨床生理学会雑誌   Vol. 35 ( 1 ) page: 39-43   2005.4

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    生活習慣病患者における血漿NOxの検討において、HbA1Cは血管内皮機能を反映する血漿NOx値低下の有意な要因と考えられた。

  127. Endotoxin from various gram-negative bacteria has differential effects on function of hepatic cytochrome P450 and drug transporters Reviewed

    UEYAMA Jun, NADAI Masayuki, KANAZAWA Hiroaki, IWASE Mitsunori, NAKAYAMA Hironao, HASHIMOTO Katsunori, YOKOI T, BABA Kenji, TAKAGI Kenji, TAKAGI Kenzo, HASEGAWA Takaaki.

    Eur J Pharmacol   Vol. 510   page: 127-134   2005.3

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  128. Role of tumor necrosis factor-alpha in down-regulation of hepatic cytochrome P450 and P-glycoprotein by endotoxin Reviewed

    MIYOSHI Mika, NADAI Masayuki, NITTA Atsumi, UEYAMA Jun, SHIMIZU Akemi, TAKAGI Kenji, NABESHIMA Toshitaka, TAKAGI Kenji, SAITO Kuniaki, HASEGAWA Takaaki.

    Eur J Pharmacol   Vol. 507   page: 229-237   2005.1

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  129. Possible involvement of P-glycoprotein in renal excretion of pazufloxacin in rats Reviewed

    SHIMIZU Akemi, MIYOSHI Mika, SUGIE Masami, UEYAMA Jun, YAMAGUCHI Takuji, SASAKI Toshinobu, TAKAGI Kenji, JIN Mingji, MIYAMOTO Ken-ichi, TSUJI Akira, HASEGAWA Takaaki.

    Eur J Pharmacol   Vol. 501   page: 151-159   2004.10

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  130. Effect of pioglitazone on endotoxin-induced decreases in hepatic drug-metabolizing enzyme activity and expression of CYP3A2 and CYP2C11 Reviewed

    UEYAMA Jun, KITAICHI Kiyoyuki, NADAI Masayuki, IWASE Mitsunori, TOMYO Nao, KANAZAWA Hiroaki, SUZUKI Ryojiro, TAKAGI Kenji, TAKAGI Kenzo, HASEGAWA Takaaki.

    Eur J Pharmacol   Vol. 498   page: 257-265   2004.9

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  131. Down-regulation of cytochrome P450 proteins and its activities by Shiga-like toxin II from Escherichia coli O157:H7 Reviewed

    KITAICHI Kiyoyuki, NAKAYAMA Hironao, UEYAMA Jun, NADAI Masayuki, BABA Kenji, TAKAGI Kenji, TAKAGI Kenzo, OHTA Michio, HASEGAWA Takaaki

    Biochem Pharmacol   Vol. 67   page: 1427-1435   2004.4

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  132. Application of ultrafiltration method to measurement of catecholamines in plasma of human and rodents by high-performance liquid chromatography Reviewed

    UEYAMA Jun, KITAICHI Kiyoyuki, IWASE Mitsunori, TAKAGI Kenji, TAKAGI Kenzo, HASEGAWA Takaaki

    J Chromatogr B   Vol. 798   page: 35-41   2003.12

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  133. Increased plasma concentration and brain penetration of methamphetamine in behaviorally sensitized rats Reviewed

    KITAICHI Kiyoyukiiyoyuki, MORISHITA Yuki, DOI Yuko, UEYAMA Jun, MATSUSHIMA Miyoko, ZHAO Ying Lan, TAKAGI Kenji, HASEGAWA Takaaki

    Eur J Pharmacol   Vol. 464   page: 39-48   2003.3

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Books 8

  1. Medical Technology

    Jun Ueyama( Role: Contributor)

    Ishiyaku Publishers,Inc.  2019.10 

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    Language:Japanese Book type:Scholarly book

  2. PEST CONTROL NEWS

    Jun Ueyama( Role: Sole author)

    2018.8 

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    Language:Japanese

  3. 日本人幼児における3つの主要な殺虫剤への曝露実態ー尿中曝露マーカーの分析ー

    上山純、上島通浩( Role: Joint author)

    環境ホルモン学会  2016 

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    Total pages:1   Language:Japanese

  4. 知の未来へ 短半減期化学物質の生物学的曝露モニタリング

    名大トピック( Role: Joint author)

    名古屋大学  2012.10 

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    Total pages:1   Language:Japanese

  5. Anticholinesterase pesticides: metabolism, neurotoxicity, and epidemiology -Novel biomarkers of organophosphate exposure- International journal

    SATOH Tetsuo, INAYAT-HUSSAIN Salmaan, KAMIJIMA Michihiro, UEYAMA Jun( Role: Joint author)

    Wiley  2011.2  ( ISBN:978-0-470-41030-1

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    Responsible for pages:289-302   Language:English Book type:Scholarly book

  6. 分子予防環境医学・Ⅲ-14 農薬類

    上島通浩、伊藤由起、上山純( Role: Joint author)

    本の泉社  2010.12  ( ISBN:4780706017

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    Language:Japanese

  7. 広範囲 血液・尿化学検査,免疫学的検査(第7版)2-その数値をどう読むか2010年増刊号

    上島通浩、上山純、高木健次、柴田英治( Role: Joint author)

    日本臨床  2010.1 

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    Language:Japanese

  8. 覚醒剤の生体内運命.「覚せい剤依存と麻薬依存」 佐藤光源、櫻井映子 編

    北市清幸、森下友貴、土井悠子、上山純、松島充代子、巽康彰、高木健次、柴田英治、高木健三、長谷川高明( Role: Joint author)

    東北大学出版会  2004.4 

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    Language:Japanese

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MISC 2

  1. Cohort profile: Aichi regional sub-cohort of the Japan Environment and Children's Study (JECS-A). Reviewed

    Ebara T, Yamada Y, Shoji N, Ito Y, Nakagawa A, Miyachi T, Ozaki Y, Omori T, Suzuki S, Kojima M, Ueyama J, Tomizawa M, Kato S, Oguri T, Matsuki T, Sato H, Oya N, Sugiura-Ogasawara M, Saitoh S, Kamijima M

    BMJ open   Vol. 9 ( 11 ) page: e028105   2019.11

  2. Within-individual and interlaboratory variability analyses of urinary metabolites measurements of organophosphorus insecticides. Reviewed

    Ito Y, Ueyama J, Nakayama SF, Isobe T, Oya N, Sato H, Ebara T, Yoshimasu K, Tsuno K, Tatsuta N, Nakai K, Kamijima M.

    J Expo Sci Environ Epidemiol.     page: Epub ahead of print]   2019.2

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Presentations 117

  1. バイオモニタリング手法を用いたマイコトキシン曝露評価の試み

    田島稔基、斎藤勲、近藤高明、鈴木康司、藤井亮輔、坪井良樹、磯部友彦、小西良子、上山純

    第9回日本医用マススペクトル学会西部会  2024.7.20  日本医用マススペクトル学会

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    Event date: 2024.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛知   Country:Japan  

  2. 松くい虫防除で散布されたアセタミプリドの 作業者暴露と尿中代謝物の関係-第2報-

    本山直樹、上山 純、斎藤 勲

    日本農薬学会第49回大会  2024.3.16  日本農薬学会

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    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  3. 日本人小児ピレスロイド系殺虫剤曝露の評価

    高木麻衣、上山純、伊藤由起、磯部友彦、岩井美幸、小林弥生、上島通浩

    第94回日本衛生学会学術総会  2024.3.8 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鹿児島   Country:Japan  

  4. 尿中忌避剤曝露マーカーのハイスループット測定法とヒトサンプルへの応用

    上山純、西原奈波、髙木麻衣、磯部友彦、斎藤勲

    第94 回日本衛生学会学術総会  2024.3.8 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:鹿児島   Country:Japan  

  5. マイコトキシンの定量的曝露評価に向けた文献調査および尿中高感度測定法の開発

    田島 稔基,野呂 涼音,斎藤 勲,上山 純

    第48 回日本医用マススペクトル学会年会  2023.9.8 

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    Event date: 2023.9

    Language:Japanese  

    Venue:愛知   Country:Japan  

  6. 職業性化学物質曝露の生物学的指標スクリーニング法の開発-尿中揮発性物質および半揮発性物質-

    棚橋 祐斗,北原 悠吾,小田切 俊樹,竹内 靖人,佐久井 徳広,斎藤 勲,上山 純

    第48 回日本医用マススペクトル学会年会  2023.9.8 

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    Event date: 2023.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:愛知   Country:Japan  

  7. LC-MS/MS を用いた便中ビタミンB 群測定法の開発

    髙目 楓華,竹村 呼,野崎 七美,平山 正昭,上山 純

    第48 回日本医用マススペクトル学会年会  2023.9.8 

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    Event date: 2023.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:愛知   Country:Japan  

  8. 固相ミニカートリッジSmart-SPE を前処理法に用いたLC-MS/MS による血中薬物同時定量法

    石原 みゆ,本多 祥子,梶本 葵里,上出 真琴,寿台 直人,上山 純,鈴木 隆佳

    第48 回日本医用マススペクトル学会年会  2023.9.8 

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    Event date: 2023.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:愛知   Country:Japan  

  9. Redox state of human serum albumin predicts 1-year prognosis in patients with heart failure: a single-center prospective cohort study International conference

    Taiki Nishikawa, Jun Ueyama, Shinjiro Miyata ,Shinya Shimizu, Yoshihisa Shibata, Sumio Yamada

    European Society of Cardiology congress 2023  2023.8.26 

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    Event date: 2023.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Netherlands  

  10. Human biomonitoringによる曝露評価-バイオモニタリングにおける化学分析- Invited

    上山純

    第2回環境化学物質3学会合同大会  2023.6.2 

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    Event date: 2023.5 - 2023.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:徳島   Country:Japan  

  11. 生体試料分析の仕方と読み方と頼み方 -衛生学の領域から― Invited

    上山純

    大学院保健学研究科 第92回保健学セミナー  2023.5.24  藤田医科大学

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    Event date: 2023.5

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:愛知   Country:Japan  

  12. 職業的化学物質ばく露評価に向けた尿中半揮発性物質の網羅的測定法の開発

    上山純、北原悠吾、棚橋祐斗、竹内靖人、佐久井徳広、斎藤勲

    第93回日本衛生学会学術総会  2023.3.4 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京  

  13. Association of redox state of human serum albumin with severity in patients with heart failure: a cross-sectional study International conference

    Taiki Nishikawa; Shinya Shimizu; Haruo Kamiya; Jun Ueyama, Sumio Yamada

    9th Asian Preventive Cardiology & Cardiac Rehabilitation Conference  2022.11.26 

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    Event date: 2022.11

    Language:English   Presentation type:Oral presentation (general)  

  14. 化学物質曝露モニタリング研究を支えるバイオマーカーデータベース構築

    上山純、北原悠吾、竹内靖人、棚橋祐斗、佐久井徳広、斎藤勲

    第49回生物学的モニタリング・バイオマーカー研究会  2022.10.22  日本産業衛生学会

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    Event date: 2022.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:熊本  

  15. 職業的な化学物質ばく露評価に向けた尿中半揮発性物質の網羅的測定法の開発

    北原悠吾、棚橋祐斗、竹内靖人、佐久井徳広、斎藤勲、上山純

    第49回生物学的モニタリング・バイオマーカー研究会  2022.10.22  日本産業衛生学会

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    Event date: 2022.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:熊本  

  16. A preliminary study on the effect of pesticide intake on gut microbiota and metabolites in middle-aged and elderly Japanese International conference

    Mai Hayashi, Masaaki Hirayama, Nanami Nishihara, Yugo Kitahara, Takaaki Kondo, Mikako Ito , Kinji Ohno, Jun Ueyama

    International Society of Exposure Science 2022 Annual Meeting  2022.9.27 

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    Event date: 2022.9

    Language:English   Presentation type:Poster presentation  

    Venue:Lisbon   Country:Portugal  

  17. Simultaneous analysis of urinary insect repellents and its metabolites using high-performance liquid chromatography-tandem mass spectrometry International conference

    Nanami Nishihara, Tomohiko Isobe, Mai Takagi, Isao Saito, Shoji Nakayama, Miyuki Iwai-Shimada, Tatsuya Kunisue, Tomoko Oguri, Jun Ueyama

    International Society of Exposure Science 2022 Annual Meeting  2022.9.27 

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    Event date: 2022.9

    Language:English   Presentation type:Poster presentation  

    Venue:Lisbon   Country:Portugal  

  18. Temporal trend and cross-sectional characterization of urinary concentrations of glyphosate in Japanese children from 2006 to 2015 International conference

    International Society of Exposure Science 2022 Annual Meeting  2022.9.28 

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    Event date: 2022.9

    Language:English   Presentation type:Poster presentation  

    Venue:Lisbon   Country:Portugal  

  19. 人囮法によるヒトスジシマカ雌成虫の捕獲数についての予測モデルの開発

    渡邉 悟 、北原悠吾、西原奈波、中根邦彦、近藤高明、上山 純

    第68回東海公衆衛生学会学術大会  2022.7.2 

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    Event date: 2022.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鈴鹿、三重  

  20. 化学物質の体内動態を把握するためのパーソナルケア製品使用と食事をコントロールした介入試験の提案

    磯部友彦、中山祥嗣、岩井美幸、高木麻衣、上山 純、小栗朋子 、篠原直秀、国末達也、仲山 慶、田上瑠美

    環境化学物質3学会合同大会  2022.6.14 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:富山   Country:Japan  

  21. Suspected phenolic endocrine-disrupting compounds in human urine and exposure media: estimation of exposure levels and excretion rates

    2022.6.14 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  22. Validation and Application of Analytical Method of Urinary Repellents

    Jun Ueyama1, Nanami Nishihara, Mai Takagi, Miyuki Iwai, Yugo Kitahara, Tomohiko Isobe

    2022.6.14 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  23. 人囮法によるヒトスジシマカ雌成虫の捕獲数を予測する モデルの開発

    渡邉 悟、北原 悠吾、西原 奈波、中根 邦彦、 近藤 高明、上山 純

    第92回日本衛生学会学術総会  2022.3.22  日本衛生学会

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    Event date: 2022.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:オンライン  

  24. 尿中有機リン系殺虫剤代謝物濃度と便中短鎖脂肪酸濃 度の関係

    林 舞衣、平山 正昭、角田 菜緒、北原 悠吾、斎藤 勲、 伊藤 美佳子、大野 欽司、上山 純

    第92回日本衛生学会学術総会  2022.3.22  日本衛生学会

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    Event date: 2022.3

    Language:Japanese   Presentation type:Poster presentation  

  25. 尿中忌避剤および代謝物同時測定法の妥当性評価とそ の応用

    西原 奈波、藪本 奈那、白石 愛深、髙木 麻衣、 磯部 友彦、上山 純

    第92回日本衛生学会学術総会  2022.3.22  日本衛生学会

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    Event date: 2022.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:オンライン  

  26. 生体試料を用いた化学物質ばく露評価研究 Invited

    上山純

    LaMer公開シンポジウム  2022.1.27  愛媛大学

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    Event date: 2022.1

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  27. 見る聞く触る 現場からまなぶ自動化の実際 Invited

    Laboratory Automation Developers Conference 2021  2021.12.17  Laboratory Automation Supplier's Association

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    Event date: 2021.12

    Language:Japanese  

    Venue:オンライン  

  28. 昆虫食におけるヒ素・重金属のリスク評価

    北原悠吾, 野村洸司, 上田琢也, 西原奈波, 斎藤勲, 上山純

    日本食品衛生学会第117回学術講演会  2021.10.26 

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    Event date: 2021.10

    Presentation type:Poster presentation  

  29. Characteristics of glyphosate exposure level in Japanese children by biological monitoring method using LC-MS/MS

    2021.9.17 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  30. ヒト尿中およびパーソナルケア製品中の フェノール性内分泌かく乱化学物質:濃度変動と曝露評価

    大浦 奏、田上 瑠美、上山 純、小栗 朋子、磯部 友彦、国末 達也

    第23回環境ホルモン学会研究会  2021.9.12 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  31. 尿サンプルを対象とした自動サンプル 前処理システムの導入の理想と現実 Invited

    上山純

    Laboratory Automation月例勉強会  2021.8.20  Laboratory Automation Supplier's Association

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    Event date: 2021.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:オンライン  

  32. web調査を利用した蚊の穿刺被害把握の試み

    上山純、中根邦彦、渡邉悟、中根敏裕、青山政美、服部悟、西原奈波、北原悠吾、近藤高明、斎藤勲

    第67回東海公衆衛生学会学術大会  2021.7.3  東海公衆衛生学会

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    Event date: 2021.7

    Language:Japanese   Presentation type:Poster presentation  

  33. 日常的に使用する殺虫剤や忌避剤のばく露を把握する Invited

    上山純

    第91回日本衛生学会市民公開講座  2021.3.6  日本衛生学会

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    Event date: 2021.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:富山、web開催   Country:Japan  

  34. 尿中曝露マーカー測定におけるクレアチニン調整希釈法の有用性の検討

    北原 悠吾、野村洸司、浜田梨沙、藤原 有花、斎藤勲、上山純

    第91回 日本衛生学会学術総会   2021.3.7 

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    Event date: 2021.3

    Language:English   Presentation type:Poster presentation  

    Venue:富山    Country:Japan  

  35. 1.5歳児を対象としたピレスロイド系殺虫剤代謝物の一斉定量分析

    上山純、伊藤由起、大矢奈穂子、浜田梨沙、上田裕子、小田昌也、加藤沙耶香、佐藤博貴、榎原毅、上島通浩

    第91回 日本衛生学会学術総会   2021.3.7 

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    Event date: 2021.3

    Language:English   Presentation type:Poster presentation  

    Venue:富山    Country:Japan  

  36. 尿中新規忌避剤ピカリジンの高感度測定法の検討

    西原奈波、高須未波、野村洸司、斎藤勲、上山純

    第91回 日本衛生学会学術総会   2021.3.7 

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    Event date: 2021.3

    Language:English   Presentation type:Poster presentation  

    Venue:富山    Country:Japan  

  37. 国内衛生行政による蚊のサーベイランス実態調査および成虫発生予測の試み

    渡邉 悟、余合 結、中根邦彦、上山 純

    第91回 日本衛生学会学術総会   2021.3.7 

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    Event date: 2021.3

    Language:English   Presentation type:Poster presentation  

    Venue:富山    Country:Japan  

  38. LC-MS/MSを用いた尿中グリホサート分析法の開発 Invited

    上山純

    アジレント・テクノロジー サンプル前処理ウェビナー2020特別講演  2020.10.16  アジレントテクノロジー株式会社

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    Event date: 2020.10

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:web開催   Country:Japan  

  39. CHARACTERISTICS OF URINARY METABOLITES AS A BIOMARKER OF HOUSEHOLD PYRETHROID INSECTICIDES International conference

    R. Hamada, K. Wada, M. Oda, Y. Ueda, I. Saito, M. Kamijima, K. Nakane, T. Kondo, C. Nagata, J. Ueyama

    11th International Symposium on Biological Monitoring in Occupational and Environmental Health  2019.8.29 

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    Event date: 2019.8

    Language:English   Presentation type:Poster presentation  

  40. 害虫忌避剤ディートの尿中代謝物高感度測定法の開発

    上山純, 上瀬佳菜,浜田梨沙,中根邦彦,近藤高明,佐藤光夫,斎藤勲

    第89回 日本衛生学会学術総会 

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    Event date: 2019.2

    Language:Japanese   Presentation type:Poster presentation  

    Venue:名古屋   Country:Japan  

  41. 1才半児におけるジノテフラン曝露量と生活環境および食意識との関連

    大矢奈穂子,伊藤由起,上山純,加藤沙耶香,松木太郎,佐藤博貴,齋藤伸治,杉浦真弓,榎原毅,上島通浩

    第89回 日本衛生学会学術総会 

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    Event date: 2019.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  42. 便中短鎖脂肪酸分析における測定前変動要因の解明と便凍結乾燥処理の有用性の検証

    小田真也, 杉立久仁代, 佐久井徳広, 瀧本圭一, 伊藤美佳子, 平山正昭, 大野欽司, 上山純

    第88回 日本衛生学会学術総会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  43. 日本の幼児における有機リン系殺虫剤曝露と生活環境との関連

    伊藤由起、大矢奈穂子、日置啓介、上山 純、青井亜里沙、小栗朋子、加藤沙耶香、齋藤伸治、榎原 毅、上島通浩

    第88回 日本衛生学会学術総会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  44. 使用済み紙おむつを用いた1歳半児における尿中ネオニコチノイド系殺虫剤の測定

    大矢奈穂子、伊藤由起、上山 純、青井亜里沙、小栗朋子、加藤沙耶香、榎原 毅、齋藤伸治、上島通浩

    第88回 日本衛生学会学術総会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  45. 新規ピレスロイド系殺虫剤代謝物の3歳児尿中濃度に関する基礎的調査

    上田裕子、市川みずき、斎藤勲、大坂彩、野村洸司、近藤高明、中根邦彦, 上山純

    第88回 日本衛生学会学術総会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  46. バイオモニタリング手法を用いた日本人小児ピレスロイド系殺虫剤曝露レベルの国際比較

    上山 純、上田裕子、伊藤由起、榎原 毅、大矢奈穂子、加藤沙耶香、小栗朋子、庄司直人、齋藤伸治、上島通浩

    第88回 日本衛生学会学術総会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  47. 日本人妊婦の尿中ネオニコチノイド系農薬濃度

    飴田 玲伽、青井 亜里沙、上山 純、西浜 柚季子、 吉永 淳、久田 文、下平 和久、加藤 進昌

    環境ホルモン学会 第19回研究発表会  

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    Event date: 2016.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:茨城県つくば市   Country:Japan  

  48. ラットを用いた殺虫剤アセタミプリドおよび代謝物の血中および尿中動態

    生田勇太郎、上山純、青井亜里沙、近藤高明、涌澤伸哉、伊藤由起、上島通浩、斎藤勲

    第86回日本衛生学会学術総会 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:旭川   Country:Japan  

    【目的】アセタミプリド(acetamiprid, ACE)はネオニコチノイド系殺虫剤の一種で、安定的で効率的な農産物生産に使用されているだけでなく、ガーデニングや林業(松枯れ防除等)にも用いられており、身近な化学物質として生活環境中に存在している。近年、バイオモニタリング手法を用いたACE曝露評価の試みが進んでいる。すなわち、尿中に排泄されるACEおよびその代謝物を定量分析し、曝露量推定を実施するという試みである。ACE曝露量と尿中排泄量の関係は不明な点もあり、本研究ではラットを用いたACEおよびその代謝物の体内動態、特に尿中排泄動態の把握を目的とした。
    【方法】ラット(n=6)にACEを頸静脈内投与および経口投与し(7.1 mg/kg, 2年間慢性毒性/発がん性併合試験の無毒性量7.1 mg/kg 体重/日を参考)、経時的に採尿および採血を行った。採取検体からACEおよび代謝物であるdesmethyl-ACE(des-ACE)を液体クロマトグラフ―四重極質量分析計、6-Chloronicotinic Acid(6CN)をガスクロマトグラフ―質量分析計で測定し、動態解析を行った。
    【結果と考察】静脈内投与実験で得られたACEの血中半減期(t1/2)は3.0±0.4 hrであり、血中薬物濃度−時間曲線下面積より生物学的利用率は82%と算出された。経口投与されたACEは168時間以内に尿中(mol換算)に未変化体として約5%、des-ACEは約18%および6CNは約10%が排泄され、バラツキはそれぞれ23%、32%および37% (CV%)であった。投与後の最高尿中濃度時間はACE6 hr以内、des-ACEおよび6CNで6 hrから12 hrであった。未変化体は代謝物に比べて尿中に排泄される割合は小さいが、排泄量のバラツキが少ないこと、比較的早期に尿中に排泄されるという体内動態の特徴を明らかにした。

  49. 尿中有機リン系殺虫剤代謝物測定の個人間変動と施設間差についての検討

    伊藤由起、上山純、中山祥嗣、磯部友彦、佐藤博貴、大矢奈穂子、仲井邦彦、上島通浩

    第86回日本衛生学会学術総会 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:旭川   Country:Japan  

  50. 使用済みオムツを用いた1歳半児における尿中有機リン系殺虫剤曝露量の測定

    大矢奈穂子、伊藤由起、日置啓介、浅井祐哉、青井愛里沙、上山純、小栗朋子、加藤沙耶香、榎原毅、上島通浩

    第86回日本衛生学会学術総会 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:旭川   Country:Japan  

  51. Measurement of concentrations of organophosphate insecticide metabolites in urine extracted from used diapers in 1.5-year-old children International conference

    Naoko Oya, Yuki Ito, Keisuke Hioki, Yuya Asai, Arisa Aoi, Yuka Sugiura, Jun Ueyama, Tomoko Oguri, Sayaka Kato, Takeshi Ebara, Michihiro Kamijima

    2nd international conference on human biomonitoring 

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    Event date: 2016.4

    Language:English   Presentation type:Poster presentation  

    Country:Germany  

  52. Concentration s of urinary pyrethroid metabolites in Japanese women between 1994-2011 International conference

    Jun Ueyama, Koouji H Harada, Akio Koizumi, Yutaro Ikuta, Takaaki Kondo, Isao Saito, Michihiro Kamijima

    2nd international conference on human biomonitoring 

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    Event date: 2016.4

    Language:English   Presentation type:Poster presentation  

    Country:Germany  

  53. Interlaboratory and intraindividual variability analysis in measurements of urinary metabolites of organophosphorus insecticides International conference

    Yuki Ito, Jun Ueyama,Shoji Nakayama, Tomohiko Isobe, Hirotaka Sato, Naoko Oya, Koichi Yoshimasu, Kanami Tsuno, Nozomi Tatsuta, Kunihiko Nakai, Michihiro Kamijima

    2nd international conference on human biomonitoring 

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    Event date: 2016.4

    Language:English   Presentation type:Poster presentation  

    Country:Germany  

  54. バイオモニタリング手法を用いたネオニコチノイド系殺虫剤の曝露評価

    上山純,末永隆次郎,永美大志,夏川周介,柴田英治,近藤高明,上島通浩,斎藤勲

    平成27年度日本産業衛生学会 東海地方会 

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    Event date: 2015.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  55. 有機リン系殺虫剤分解酵素活性と尿中代謝物の関連

    佐藤博貴,伊藤由紀,上山純,加納裕也,荒川朋弥,五藤雅博,近藤高明,杉浦友香,斎藤勲,柴田英治,上島通浩

    平成27年度日本産業衛生学会 東海地方会 

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    Event date: 2015.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  56. 使用済みオムツを利用した尿中代謝物一斉分析法の開発 International conference

    杉浦友香、上山純、上田裕子、伊藤由起、涌澤伸哉、上島通浩

    第43回産業中毒・生物学的モニタリング研究会 

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    Event date: 2015.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛知県   Country:Japan  

  57. 尿中有機リン系殺虫剤代謝物測定の施設間、個人間変動についての検討

    伊藤由起、上山 純、中山祥嗣、磯部友彦、佐藤博貴、仲井邦彦、上島通浩

    第43回産業中毒・生物学的モニタリング研究会 

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    Event date: 2015.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  58. 殺虫剤類の個人曝露量測定と健康リスク評価

    上島通浩、伊藤由起、上山純

    第42回 日本毒性学会学術年会 シンポジウム 

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    Event date: 2015.6 - 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢   Country:Japan  

  59. 使い捨てオムツを用いた尿中低分子代謝物類の網羅的分析

    杉浦友香、上山純、上田裕子、涌澤伸哉、上島通浩

    第85回日本衛生学会学術総会 

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    Event date: 2015.3

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  60. 日本人における尿中殺虫剤曝露指標濃度の過去20年間の経年推移

    上山純、原田浩二、杉浦友香、大坂彩、小泉昭夫、上島通浩

    第85回日本衛生学会学術総会 

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    Event date: 2015.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  61. 3歳児における尿中殺虫剤曝露指標の相関関係

    上山純、大坂彩、野村洸司、斎藤勲、近藤高明、 黄木弘子、高石亜有子、伊藤由起、上島通浩

    第85回日本衛生学会学術総会 

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    Event date: 2015.3

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  62. 3歳児を対象とした有機リン系・ピレスロイド系・ネオニコチノイド系殺虫剤の 尿中曝露指標一斉分析

    大坂彩, 上山純, 野村洸司, 斎藤勲, 近藤高明, 黄木弘子, 高石亜有子, 伊藤由起, 上島通浩

    第42回産業中毒・生物学的モニタリング研究会 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:松本市   Country:Japan  

  63. 日本人における尿中ネオニコチノイド系 殺虫剤とその代謝物の濃度分布

    上山純, 野村洸司, 斎藤勲, 近藤高明, 岩田豊人, 村田勝敬, 涌澤伸哉, 上島通浩

    第41回日本毒性学会学術年会 

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    Event date: 2014.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  64. 日本人小児を対象とした尿中ピレスロイド系殺虫剤代謝物の高感度分析

    大坂彩, 上山純, 近藤高明, 野村洸司, 斎藤勲, 犬塚君雄, 黄木弘子, 高石亜有子, 上島通浩

    第84回日本衛生学会学術総会 

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    Event date: 2014.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  65. LC-MS/MSによる尿中のネオニコチノイド系殺虫剤同時定量分析法の開発

    上山純, 野村洸司, 斎藤勲, 近藤高明, 伊藤由起, 上島通浩

    第84回に本衛生学会学術総会 

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    Event date: 2014.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:岡山市   Country:Japan  

  66. Concentration distribution of urinary pyrethroid insecticide metabolites in Japanese workers International conference

    Jun Ueyama, Hiroshi Nomura, Isao Saito, Takaaki Kondo, Yuka Sugiura, Katsuyuki Murata, Toyoto Iwata, Masahiro Gotoh, Shinya Wakusawa, Michihiro Kamijima

    International Society of Exposure Science 2013 Annual Meeting  2013.8.20 

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    Event date: 2013.8

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Basel, Switzerland  

  67. Quantitation of neonicotinoid metabolites in human urine using gas chromatography-mass spectrometry International conference

    Hiroshi Nomura, Jun Ueyama, Takaaki Kondo, Isao Saito, Katsuyuki Murata, Toyoto Iwata, Shinya Wakusawa, Michihiro Kamijima

    International Society of Exposure Science 2013 Annual Meeting  2013.8.20 

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    Event date: 2013.8

    Language:English   Presentation type:Poster presentation  

    Venue:Basel, Switzerland  

  68. Simultaneous determination of urinary pyrethroid insecticide metabolites in disposable diaper samples

    Jun Ueyama, Shun Saito, Takaaki Kondo, Isao Saito, Masahiro Gotoh, Kunihiko Nakai, Michihiro Kamijima

    7th International Conference on the Science of Exposure Assessment  2012.7.3 

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    Event date: 2012.7

    Language:English   Presentation type:Poster presentation  

  69. パラオキソナーゼ1遺伝子多型と腎機能評価指標との関連-予備的解析-

    上山純、本郷あやの、近藤高明、森田えみ、川合紗世、岡田理恵子、伊藤宜則、内藤真理子、若井健志、浜島信之

    第82回日本衛生学会学術総会 

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    Event date: 2012.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都   Country:Japan  

  70. 血清脂肪酸(FA)とFA摂取量およびメタボリックシンドローム(MetS)リスク

    田中哲也、近藤高明、喜田優人、上山純、鈴木康司、井上孝、伊藤宜則、若井健志、浜島信之

    第82回日本衛生学会学術総会 

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    Event date: 2012.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  71. 殺虫剤撒布職域従事者における尿中クレアチニン分析値の検討

    大坂彩、上山純、近藤高明、五藤雅博、柴田英治、涌澤伸哉、斎藤勲、上島通浩

    第82回日本衛生学会学術総会 

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    Event date: 2012.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都   Country:Japan  

  72. Concentration of urinary organophosphorus insecticide metabolites in Japanese workers International conference

    Jun Ueyama, Isao Saito, Takaaki Kondo, Taki Tomoko, Akiko Kimata, Shun Saito, Katsuyuki Murata, Toyoto Iwata, Masahiro Goto, Eiji Shibata, Shinya Wakusawa, Michihiro Kamijima

    21st Annual Meeting of The International Society of Exposure Science 

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    Event date: 2011.10

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

    Determination of urinary dialkylphosphate (DAP) levels enables us to monitor the systemic organophosphorus insecticide (OP) exposure at individual levels. Limited data are available on the background levels and occupational OP exposures in Japan, despite frequent OP application for agriculture and indoor extermination. The purpose of this study was to reveal the distribution and seasonal difference of urinary dialkylphosphate (DAP) concentrations in Japanese workers. Urine samples were collected in both summer and winter seasons from 339 Japanese adults who engage in the food distribution (FD, n=164), apple farming (AF, n=147) and pest control operation (PCO, n=28). Statistical analysis for group and seasonal differences of urinary DAPs were performed by Wilcoxon signed-rank and Kruskal-Wallis test, respectively, each followed by multiple comparisons. This is one of the first studies to document fundamental characteristics of urinary DAP concentrations in Japanese adults. Further nationwide studies covering different areas and wider age spans are needed to investigate detailed characteristics of OP exposure level in Japan.

  73. 使い捨て紙オムツを利用した尿中殺虫剤代謝物測定法の検討

    齋藤峻、上山純、斎藤勲、近藤高明、涌澤伸哉、 五藤雅博、柴田英治、近並由佳、仲井邦彦、上島通浩

    第 39 回 産業中毒・生物学的モニタリング研究会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:昭和大学医学部 1 号館 7 階 講堂   Country:Japan  

    【目的】現在、未熟な解毒能力やその生活様態から化学物質による健康影響リスクが高いと予想されている新生児や乳児を対象として、殺虫剤の健康影響に関する研究が進んでいる。生活環境中での殺虫剤曝露レベルの評価には、尿中の代謝物を高感度にモニタリングする方法が主に用いられるが、排尿が自立していない新生児や乳児からの採尿は困難であり、疫学調査実施の障害となっている。今回我々は、使い捨て紙オムツからピレスロイド系殺虫剤代謝物である3-phenoxybenzoic acid (3-PBA) およびtrans-chrysanthemumdicarboxylic acid (CDCA) を抽出および分離分析し、検出感度および再現性が良好な測定法の開発を試みた。
    【方法】使い捨て紙オムツの皮膚接触部分である表面材には尿中3-PBAおよびCDCAの吸着が認められなかったため、尿の吸収材(綿状パルプ+高分子吸収ポリマー)を約150 mg採取し、これに既知の濃度の尿2 mlを添加および1時間の室温放置した後に各種検討を行った。固相抽出用カラムにサンプルを充填し、アセトン5 mlを流速1 ml/minで代謝物を溶出した。窒素ガスによる抽出液の濃縮後、精製水で2 mlまでメスアップしたものを既報に従って定量分析した。分離分析にはガスクロマトグラフ質量分析計(Agilent社製)を用いた。再現性の検討は日本および米国企業の計3社5製品の使い捨てオムツ(diaper A-E)について行った。また、27名の殺虫剤散布職域従事者から得た尿を用いて、尿を直接分析する従来法とオムツ抽出法による測定値の比較検討を行った。
    【結果】5種の使い捨てオムツにおける絶対回収率を求めた結果、国内企業のdiaper Aが最も高い回収率を示した。diaper Aにおける3-PBA濃度0.4から20.4 µg/Lでの絶対回収率は90.3–118.1 %、CDCA濃度0.5から20.0 µg/Lでは50.0–86.8 %であり、良好な直線性の検量線を作成することができた(3-PBA, r2 = 0.9998; CDCA, r2 = 0.9977)。同様の代謝物濃度域における日内変動および日差変動のCV%は、3-PBAで5.3-16.0%および3.7-11.7%、CDCAで4.0-8.7%および4.2-8.1%であった。2 mlの尿を含む吸収材から分析した場合の検出限界値は、それぞれ0.026 µg/L (3-PBA) および0.17 µg/L (CDCA) であった。diaper BからEを用いた場合、検出限界はdiaper Aに劣るものの、いずれも代謝物濃度範囲0.5-20 µg/Lにおいてr2 = 0.9967以上の直線性を得ることができた。殺虫剤散布職域従事者尿を用いた検討において、従来法およびオムツ抽出法から得られた濃度のスピアマンの相関係数は、3-PBAでは濃度範囲1.5-129.5 µg/Lにおいて0.994、1.5-16.8 µg/Lにおいて0.992、CDCAでは濃度範囲0.3-22.7 µg/Lにおいて0.993、0.3-10.9 µg/Lにおいて0.983であった。
    【考察・結論】本研究では、1)使い捨てオムツから殺虫剤代謝物を含む尿を比較的少量の溶媒で溶出可能であること、2)この抽出法は良好な再現性を示し、採取オムツの種類に合わせた検量線を作成することにより、一般健常人尿における低い代謝物濃度でも従来法とほぼ同等の感度で定量できることを明らかにした。
    発表ではさらにサンプル保存性に関する検討結果を追加する予定である。本測定法は、新生児や乳児に調査のための負担をかけることなく、使用後の紙オムツを用いてピレスロイド系殺虫剤代謝物量をモニタリングできる優れた測定法であることが示唆された。

  74. 一般生活集団における血清中脂肪酸とメタボリックシンドローム診断項目との関連

    田中哲也, 近藤高明, 喜田優人, 上山純, 浜島信之, 鈴木康司, 井上孝, 倉岡光穂, 王音晴, 蓮井恵子

    第81回日本衛生学会学術総会 

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    Event date: 2011.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  75. 問診票による身体活動量推定量と血圧や血清生化学検査値との関連

    近藤高明, 加藤千秋, 喜田優人, 田中哲也, 上山純

    第81回日本衛生学会学術総会 

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    Event date: 2011.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  76. 24時間尿中クレアチニン排泄量予測値を用いた24時間尿中殺虫剤代謝物排泄量の推定

    齋藤峻, 上山純, 近藤高明, 田中哲也, 廣澤菜緒子, 北洞久美子, 高木健次, 上島通浩, 涌澤伸哉

    第81回日本衛生学会学術総会 

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    Event date: 2011.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  77. 異なる前処理による尿中ピレスロイド代謝産物測定値の変動

    登島弘基, 吉永淳, 白石寛明, 伊藤由起, 上島通浩, 上山純

    第81回日本衛生学会学術総会 

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    Event date: 2011.3

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  78. 殺虫剤曝露指標の実践的応用を目指した基礎的研究

    上山純, 近藤高明, 斎藤勲, 五藤雅博, 長谷川高明, 上島通浩

    第81回日本衛生学会学術総会 

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    Event date: 2011.3

    Language:Japanese  

    Country:Japan  

  79. 日本人の一般健常集団における種々の疾患歴とH.pylori感染との関連

    喜田優人, 近藤高明, 上山純,田中哲也, 川合紗世, 森田えみ, 伊藤宜則, 内藤真理子, 若井建志, 浜島信之

    第81回日本衛生学会学術総会 

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    Event date: 2011.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  80. ペルメトリン由来3-フェノキシ安息香酸の尿中排泄量に対する有機リン系殺虫剤の影響

    藤中沙奈恵, 上山純, 廣澤奈緒子, 近藤高明, 上島通浩, 高木健次, 平手彩夏, 長谷川高明, 涌澤伸哉

    第 38 回有機溶剤中毒研究会・第 43 回生物学的モニタリング・バイオマーカー研究会合同研究会  

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  81. 非喫煙成人女性での尿中コチニン値と受動喫煙との関連

    喜田優人, 近藤高明, 田中哲也, 中川優子, 木下香織, 鈴木麻予, 服部由花, 一ノ谷英憲, 木全明子, 上山純, 森田えみ, 田村高志, 栗木砂家加, 冨田耕太郎, 岡田理恵子, 川合紗世, 菱田朝陽, 内藤真理子, 若井建志, 浜島信之

    第56回東海公衆衛生学会学術大会 

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    Event date: 2010.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  82. 健常成人集団での血清carotenoid値とmetabolic syndrome診断項目集積数との関連

    田中哲也, 近藤高明, 田優人, 一ノ谷英憲, 山本佳那実, 鈴木麻予, 服部由花, 木全明子, 上山純

    第56回東海公衆衛生学会学術大会 

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    Event date: 2010.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  83. 健常成人集団での血清carotenoid値と高密度との関連

    近藤高明, 一ノ谷秀憲, 山本佳那実, 木全明子, 鈴木麻予, 服部由花, 木下香織, 中川優子, 上山純

    第80回日本衛生学会学術総会 

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    Event date: 2010.4

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  84. ピレスロイド系殺虫剤代謝に関与するUDP-グルクロン酸転移酵素分子種の同定

    齋藤峻, 上山純, 廣澤奈緒子, 望月愛子, 木全明子, 高木健次, 涌澤伸哉

    第80回日本衛生学会学術総会 

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    Event date: 2010.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  85. 使い捨て紙おむつを利用した尿中殺虫剤代謝物測定の試み

    上山純, 伊藤牧, 齋藤勲, 高木健次, 近藤高明, 涌澤伸哉, 仲井邦彦, 佐藤洋, 上島通浩

    第80回日本衛生学会学術総会 

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    Event date: 2010.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  86. 一般生活者集団および殺虫剤散布職域集団の尿中有機リン系殺虫剤代謝物量

    廣澤奈緒子, 上山純, 上島通浩, 木全明子, 岡村愛, 那須民江, 柴田英治, 五藤雅博、深谷幸生, 近藤高明, 高木健次, 涌沢伸哉

    第36回日本トキシコロジー学会学術年会 

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    Event date: 2009.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  87. 日本人中高齢者における尿中ピレスロイド系殺虫剤代謝物および血中酸化ストレス指標との関連性

    上山純, 木全明子, 上島通浩, 濱島信之, 鈴木康司, 井上孝, 伊藤宜則, 宮本謙一, 長谷川高明 ,高木健次, 涌沢伸哉, 近藤高明

    第79回日本衛生学会学術総会 

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    Event date: 2009.3

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  88. 害虫防除作業者集団におけるフェニトロチオン散布とその尿中代謝物量との関連

    岡村愛, 上島道浩, 上山純、 高木健次, 柴田英治, 内藤久雄、五藤雅博, 斉藤勲、那須民江.

    第79回日本衛生学会学術総会 

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    Event date: 2009.3

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  89. 健常成人集団における血清8-iso-PGF2αと骨密度との関連

    近藤高明、上山純、木全明子、山本佳那美、鈴木康司、井上孝、伊藤宣則、浜島信之

    第79回日本衛生学会学術総会 

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    Event date: 2009.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  90. ピレスロイド系殺虫剤代謝産物の体内動態における性差

    "廣澤奈緒子1) , 上山純1,2) , 望月愛子1) , 木全明子1) , 高木健次1) , 近藤高明1) , 高木健三1) , 涌澤伸哉1) , 長谷川高明3)"

    第79回日本衛生学会学術総会 

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    Event date: 2009.3

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  91. Testicular toxicity in mice after combined exposure to pyrethroid and organophosphorus insecticides

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    Event date: 2008.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  92. Patterns of beta-glucuronidase in pesticide self- poisoning. International conference

    7th Asia Pacific Association of Medical Toxicolog 

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    Event date: 2008.12

    Language:English   Presentation type:Oral presentation (general)  

  93. ダイアジノンとcis-ペルメトリンの混合曝露によるマウス精巣への影響

    王棟、上島道浩、岡村愛、伊藤由起、柳場由絵、上山純、那須民江

    平成20年日本産業衛生学会東海地方学会 

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    Event date: 2008.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  94. 一般生活集団における合成ピレスロイド系化合物の尿中代謝物濃度

    上山純、木全明子、上島通浩、高木健次、涌く澤伸哉、高木健三、斎藤勲、宮本謙一、長谷川高明

    第35回日本トキシコロジー学会学術年会 

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    Event date: 2008.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  95. 男性健常成人集団における血中polyamine値の分布とmetabolic risk factorとの関連性

    山本佳那美、近藤高明、木全明子、上山純、高木健次

    第78回日本衛生学会総会 

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    Event date: 2008.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  96. 合成ピレスロイド系殺虫剤ペルメトリン(trans;cis体)のマウス生殖毒性に関する研究

    張淑芸、伊藤由起、柳場由絵、上山純、岡村愛、上島道浩、那須民江

    第78回日本衛生学会総会 

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    Event date: 2008.3

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  97. ガスクロマトグラフ質量分析計によるフェニトロチオンの特異的尿中代謝産物3-メチル-4-ニトロフェノールの高感度測定法の開発

    岡村愛、上島道浩、斉藤勲、市原学、伊藤由起、五藤雅博、柴田英治、髙木健次、近藤高明、上山純、那須民江

    第78回日本衛生学会総会 

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    Event date: 2008.3

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  98. 健常成人集団でのCETP TaqIB遺伝子多型と血管内皮由来NO濃度との関連性

    近藤高明、上山純、吉武順子、木全明子、山本佳那美、鈴木康司、井上孝、伊藤宣則、浜島信之

    第78回日本衛生学会総会 

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    Event date: 2008.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  99. 男性健常成人集団における血中polyamine値の分布とmetabolic risk factorとの関連性

    木全明子、上山純、近藤高明、山本佳那美、上島通浩、柴田英治、後藤雅博、深谷幸生、高木健次、那須民江、斉藤勲

    第78回日本衛生学会総会 

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    Event date: 2008.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  100. 有機リン系殺虫剤ダイアジノンが及ぼす2型糖尿病モデルラットの耐糖能への影響

    浅井佳寿美、上山純、望月愛子、三河由佳、王棟、上島道浩、近藤高明、長谷川高明、高木健次、高木健三、涌澤伸哉

    日本薬学会第128年会 

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    Event date: 2008.3

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    Country:Japan  

  101. ラットにおけるミカファンギンの胆汁排泄におけるMrp2およびP糖タンパク質の関与

    安部文江、上山純、加藤美樹、灘井雅行、川澄紀代、木村匡男、斉藤寛子、武山直志、野口宏、長谷川高明

    日本薬学会第128年会 

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    Event date: 2008.3

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  102. 生活習慣病モデルラットSHR/NDmcr-cpおよびSHRSP.ZFの肝臓における薬物トランスポーターの発現解析

    有沢早葵子、亀山なつみ、佐野雅幸、石田空美季、上山純、篠塚和正、涌澤伸哉

    日本薬学会第128年会 

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    Event date: 2008.3

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  103. HepG2細胞におけるdoxorubicinのP-glycoprotein発現誘導に与えるepigallocatechin gallateの影響

    石田空美季、佐野雅幸、亀山なつみ、有沢早葵子、上山純、高木健次、涌澤伸哉

    日本薬学会第128年会 

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    Event date: 2008.3

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  104. ウェスタンブロット法の内部標準物質に及ぼすエンドトキシンの影響

    望月愛子、上山純、浅井佳寿美、王棟、安部文江、長谷川高明、近藤高明、高木健三、高木健次、涌澤伸哉

    日本薬学会第128年会 

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    Event date: 2008.3

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    Country:Japan  

  105. 職業的有機リン系殺虫剤曝露が及ぼす血漿中βグルクロニダーゼ活性値への影響

    上山純、上島通浩、小笠原将人、木全明子、近藤高明、高木健三、宮本謙一、長谷川高明、佐藤哲男、斉藤勲、高木健次、涌沢伸哉

    日本薬学会第128年会 

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    Event date: 2008.3

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  106. streptozotocin誘発糖尿病ラットでのP糖タンパク誘導に伴うPKCαおよびNF-κBの発現変化

    亀山なつみ、有沢早葵子、佐野雅幸、石田空美季、上山純、高木健次、涌澤伸哉

    日本薬学会第128年会 

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    Event date: 2008.2

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    Country:Japan  

  107. Toxicity of diazinon and its metabolites increases in diabetic rats International conference

    The seventh international symposium on biological monitoring in occupational & environmental health 

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    Event date: 2007.9

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  108. Biological monitoring of exposure to organophosphorus and pyrethroid insecticides in Japan - from the viewpoint of testicular toxicity assessment- International conference

    The seventh international symposium on biological monitoring in occupational & environmental health 

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    Event date: 2007.9

    Language:English   Presentation type:Oral presentation (general)  

  109. Decrease in rat sperm motility is associated with cholinesterase activity inhibition by dichlorvos and diazinon treatment. International conference

    11th IUPAC International Congress of Pesticide Chemistry. 

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    Event date: 2006.8

    Language:English   Presentation type:Poster presentation  

  110. Permethrin may disrupt testosterone production in male mice. International conference

    11th IUPAC International Congress of Pesticide Chemistry. 

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    Event date: 2006.8

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  111. Biological monitoring of pyrethroid exposure for pest control workers. International conference

    11th IUPAC International Congress of Pesticide Chemistry. 

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    Event date: 2006.8

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  112. Effect of pioglitazone on endotoxin-induced decreases in hepatic drug-metabolizing enzyme activity and expression of CYP3A2 and CYP2C11. International conference

    The 8th Conference of the International Endotoxin Society 

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    Event date: 2004.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  113. The lack of involvement of TNF-a, IL-1 and PAF in endotoxin-induced decrease in hepatic drug-metabolizing enzyme activity. International conference

    The 18th International Congress of Clinical Chemistry and Laboratory Medicine 

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    Event date: 2002.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  114. Methamphetamine sensitization and pharmacokinetics. International conference

    XII World Congress of Psychiatry 

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    Event date: 2002.8

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  115. Pharmacokinetic changes of methamphetamine and their mechanisms in rats having behavioral sensitization to methamphetamine. International conference

    23rd Congress of Collegium Internationale Neuro-Psychopharmacologicum 

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    Event date: 2002.6

    Language:English   Presentation type:Poster presentation  

  116. Altered disposition of methamphetamine in rats repeatedly treated with methamphetamine: the possible involvement of organic cation transporters. International conference

    31th Annual Meeting Society for Neuroscience 

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    Event date: 2001.11

    Language:English   Presentation type:Poster presentation  

  117. Repeated administration of methamphetamine alters pharmacokinetic parameters of methamphetamine in rats: the possible involvement of organic cation transporters. International conference

    Congress of Collegium Internationale Neuro-Psychopharmacologicum, Regional meeting, 

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    Event date: 2001.10

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

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Research Project for Joint Research, Competitive Funding, etc. 5

  1. 化学物質体内動態モデル及び曝露逆推計モデル構築システムの開発

    Grant number:5-2003  2020.4 - 2023.3

    環境省環境研究総合推進費  安全確保領域

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\29900000 ( Direct Cost: \23000000 、 Indirect Cost:\6900000 )

  2. '脳の発達臨界期にあたる幼児期の殺虫剤ばく露量モニタリング

    Grant number:5-1551  2015.4 - 2018.3

    環境省環境研究総合推進費 

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    Grant type:Competitive

  3. 労働衛生学的なバイオモニタリング解析手法の統合に関する研究

    2015.4 - 2016.3

    那須基金 

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    Grant type:Competitive

    本研究では職業的な化学物質の曝露レベルを一つの分析機器を用いて網羅的に評価できるスクリーニング法を開発する。つまり1)既存の化学物質曝露マーカーをガスクロマトグラフ質量分析計を用いて迅速に検出できる系統的分析法の開発を行い、2)新規の化学物質曝露マーカーを探索・有用性についての評価を行う。

  4. 日本人における尿中殺虫剤代謝物レベル基本特性の包括的研究

    2012.7

    海外派遣助成 

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    Grant type:Competitive

    農薬等の予測的環境毒性試験や環境リスクアセスメント、環境中毒性物質のリスクとリスク管理、ヒトリスクを理解するための毒性学に関する最新の知見を入手し、当該研究の方向性および研究内容の発展性を明確化させることが目的で海外派遣助成を応募した。

  5. 炎症疾患における肝代謝能の低下に対するサリドマイドの効果及び分子機構論的作用機序解明

    2005.4 - 2006.3

    名古屋大学学術振興基金 

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    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 13

  1. Comprehensive Understanding of Mycotoxin Exposure Using Biomonitoring Techniques

    Grant number:23K09669  2023.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

  2. 複数の疾患リスクに関わる初経・閉経年齢を規定する生活環境因子の同定とその寄与評価

    Grant number:20H03939  2020.4 - 2024.3

    科学研究費助成事業  基盤研究(B)

    永田 知里, 上山 純, 和田 恵子, 近藤 高明

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\1300000 ( Direct Cost: \1000000 、 Indirect Cost:\300000 )

    初経・閉経年齢はがん、心血管障害等複数の疾患のリスク要因であり、疾患によりリスクを上げたり下げたりする。本研究では、学童、妊婦と出産児、地域住民を対象に、初経および閉経年齢を規定する生活環境因子を前向き研究の手法で同定する。特に、食習慣、運動、生活リズム、成長、精神発達、受動喫煙、照明環境、妊娠中の栄養・ホルモン状態、環境化学物質の観点で農薬やパーソナルケア製品使用に着目する。環境化学物質暴露、サーカディアンリズムに関しては、尿標本にて生体指標を測定する。見出された規定因子が、これらの疾患罹患に初経や閉経の時期を介しどれだけ寄与するかを算出し、リスクの背反する疾患群への予防策考案に繋げる。
    本研究は、複数の疾患のリスク要因である初経年齢、閉経年齢について、これを規定する生活習慣・環境因子を同定することを目的としている。中学2年生女子266名において血中性ホルモン、エストラジオール(E2)、テストステロン(T)、DHEAS と血中IGF-1を測定し、月経状態および第二次性徴との関連性を評価した。第二次性徴はChan (2010)らの身長スパート、体毛、にきび、乳房に関する質問票を用い、それぞれはっきり伸びている最中/ほぼ伸び終わった、はっきりと生えてきている最中/大体生え終わった、たくさんできている最中/できて大体で終わった、大きくなっている最中/ほぼ成長し終わった、に該当するか否かでグループ分けした。また、体毛、乳房の発達、月経の有無を基にターナーステージを同定した。補正医因子として年齢、肥満度、身長、両親の喫煙状態を用いた。月経が開始した女子は246名でこのうち154名は月経周期が順調であると回答した。ターナーステージではlate pubertalに相当する者が86.7%であった。DHEAS とIGF-1値はステージが高いほど有意に高く、順調な月経がある女子は月経のない女子に比べE2、IGF-1値が有意に高かった。DHEAS値 は体毛発育、DHEAS とT値はにきびの出現に有意な正の関連性を示した。尿中アクリルアミド代謝物量は、これらのホルモン値と有意な関連を示さなかった。
    本人の喫煙状態が閉経時期に影響を及ぼすことは多くの研究で知られているため、配偶者の喫煙状態の影響も、閉経前女性3090名を対象とした高山コホートにおいて評価した。対象をベースライン時の婚姻者に限り、年齢、BMI、喫煙歴、教育年数、運動習慣、出産数、初経年齢で補正した解析では、配偶者の喫煙状態、喫煙年数とも閉経とは関連が認められなかった。
    学童におけるコホートでの追跡調査は、学校・保健所関係者の協力が得られ、予定通りに順調に進行している。地域住民からなるコホートでの調査は、アウトカムを閉経に絞らず、協力を得やすいトピックも追加し依頼をしたが、開始できていない。
    学童におけるコホートでは、学校・保健所関係者との良好な連携関係を保ち、追跡調査を続ける。地域住民におけるコホートでは、大学での他の研究者と協調しながら進める。パラベンなどの環境物質の測定方法も確立されたので、対象者の年齢層を広げ、性ホルモン値や初経年齢との関連を評価する。

  3. Understanding of herbicide exposure level by biomonitoring and its application to the risk assessment

    Grant number:20K10450  2020.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Jun Ueyama

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    The purpose of this studyis to develop a world-leading urinary herbicide exposure marker assay that can be applied to a large volume of human urine samples, and to apply it to existing urine samples to elucidate the distribution of exposure levels in each population (interindividual variation), intraindividual variation, regional differences, and factors of variation over time, The research aims to elucidate the factors of variation in the distribution of exposure levels (inter-individual variation), intra-individual variation, regional differences, and changes over time, and to calculate risk assessment indices based on biomonitoring data. As a result of the research, 1) a urinary glyphosate assay method was developed that has a worldwide advantage in analytical throughput, and 2) the Japanese glyphosate exposure level was clarified for the first time.

  4. A cohort study of effects of combined exposure to obesogenic chemicals during early childhood

    Grant number:19H01078  2019.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    Kamijima Michihiro

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\390000 ( Direct Cost: \300000 、 Indirect Cost:\90000 )

    Obesity during childhood is an important public health issue because it can result in the development of type II diabetes, dyslipidemia, and hypertension later in the adulthood. In these years, a notion has been established that the environmental chemical exposure can contribute to the adipogenesis in the body and such chemicals are called as obesogen (OB). This study project aimed to clarify the exposure to OB candidates in small children in a birth cohort study, and to investigate the relationship between the exposure and the physique indices. The chemical exposure were assessed by measuring metabolites or their parent compounds excreted in the urine, and a method strategy was developed using model compounds to evaluate such exposure comprehensively. Gut microbiome in small children was also analyzed in this project from the viewpoint of its possible involvement in the toxicokinetics of OB.

  5. 家庭用ピレスロイド系殺虫剤曝露の理解に向けたバイオモニタリングの実践応用

    Grant number: 17H04132   2017.4 - 2020.3

    科学研究費補助金  基盤研究(B)

    上山純

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    Authorship:Principal investigator  Grant type:Competitive

  6. 低用量殺虫剤曝露の代謝物プロファイリング:エクスポソーム導入へのマイルストーン

    Grant number:16H05259  2016.4 - 2019.3

    科学研究費補助金  基盤研究(B)

    上島通浩

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    Authorship:Coinvestigator(s) 

  7. 尿中化学物質の網羅的分析による農薬類曝露マーカーの探索と分析法の開発

    Grant number:26460799   2014.4 - 2017.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Competitive

  8. 胎児期の非蓄積性殺虫剤曝露の解明と出生児の成長・発達への影響に関するコホート研究

    Grant number:25293151   2013.4 - 2016.3

    科学研究費補助金  基盤研究(B)

    上島通浩

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  9. 殺虫剤の生体影響リスク評価へのメタボノミクスの導入

    Grant number:20310035  2009.4 - 2011.3

    科学研究費補助金  基盤研究(B)

    上島通浩

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  10. 殺虫剤曝露指標の実践的応用を目指した基礎的研究

    Grant number:21790551   2009.4

    科学研究費補助金  若手研究(B),課題番号:21790551

    上山純

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    Authorship:Principal investigator 

  11. 健常成人集団で腹部脂肪蓄積が血管内皮機能に及ぼす影響の分析化学的・生理学的評価

    Grant number:19590626   2008.4 - 2010.3

    科学研究費補助金  基盤研究(C)

    近藤高明

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  12. 一般集団での殺虫剤曝露が健康へ及ぼす影響に関する実験的・疫学的評価

    Grant number:19790404   2007.4 - 2008.3

    科学研究費補助金  若手研究(B)

    上山 純

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    Authorship:Principal investigator  Grant type:Competitive

  13. 一般生活集団における殺虫剤曝露状況および疾患罹患時の体内動態の解明に関する研究

    Grant number:17790364   2005.4 - 2007.3

    科学研究費補助金  若手研究(B)

    上山 純

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    Authorship:Principal investigator  Grant type:Competitive

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Teaching Experience (On-campus) 1

  1. Introduction to Medical and Health Care Science

    2022

Teaching Experience (Off-campus) 1

  1. 薬物動態実習

    2010.4 - 2011.3 愛知医科大学)

 

Social Contribution 2

  1. 環境省 化学物質の人へのばく露量モニタリング調査に関するタスクフォース会合委員

    Role(s):Advisor

    環境省  2022.4

  2. 【エコチル調査】曝露評価専門委員会精度管理分科会

    環境省  2017.4

Media Coverage 3

  1. 日常的な農薬摂取が及ぼす腸内環境への影響をヒトで確認 Internet

    大学ジャーナル  2023.3

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    Author:Myself 

  2. 日本人小児における除草剤グリホサートの曝露実態を初めて観察 -バイオモニタリングを用いたリスク評価の発展に期待-

    名古屋大学医学部 研究トピック  2022.4

  3. NUトピックス 先生に一問一答

    名古屋大学  NUトピックス  表紙、先生に一問一答  2021.2

Academic Activities 3

  1. i-HBM Working Group International contribution

    Role(s):Planning, management, etc., Planning/Implementing academic research

    International Society of Exposure Science  2021.4

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    Type:Academic research 

  2. 東海公衆衛生雑誌編集委員会

    Role(s):Review, evaluation, Peer review

    東海公衆衛生学会  2022.4

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    Type:Scientific advice/Review 

  3. 農薬中毒部会

    Role(s):Planning, management, etc., Planning/Implementing academic research

    日本農村医学会  2019.4

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    Type:Academic research