Faculty Profiles - KATO, Ryuji

Papers - KATO, Ryuji

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Effects of theproperties of short peptides conjugated with cell-penetrating peptides on theirinternalization into cells. Reviewed

Matsumoto Ryo, Okochi Mina, Shimizu Kazunori, Kanie Kei, Kato Ryuji, Honda Hiroyuki

SCIENTIFIC REPORTS Vol. 5 page： 12884 2015.8

Non-invasive quality evaluation of confluent cells by orientation analysis

Sasaki Kei, Sasaki Hiroto, Takahashi Atsuki, Kanie Kei, Kang Siu, Kato Ryuji, Yuasa Tetsuya

IEICE TECHNICAL REPORT Vol. 114 ( 482 ) page： 167 - 172 2015.3

Publisher：The Institute of Electronics, Information and Communication Engineers

Although regenerative medicine is rapidly evolving toward clinical application in recent years, the fact that no effective technique to non-invasively and objectively monitor the state of cultured cells is existent hampers its realization. For this problem, an image processing/recognition technique using phase-contrast microscopy images acquired non-invasively, which first segments individual cells and then quantitatively evaluates the quality of each cell morphologically, will be a solution. However, for confluent cells it has been ineffective because the confluent cells have no decisive boundary, and then each cell cannot be segmented and characterized by the morphological features. In this research, we devise a method to quantify the state of confluent cells by scoring each pixel based on the collective feature in terms of orientation and then statistically characterizing the heterogeneity of the score distribution throughout an image. We demonstrate the efficacy of the proposed method by classifying actual microscopic images of confluent cells into proper classes using a support vector machine based on the feature derived from the orientation and heterogeneity.

Identification of an interactionbetween VWF rs7965413 and platelet count as a novel risk marker for metabolicsyndrome an extensive search of candidate polymorphisms in a case-controlstudy. Reviewed

Nakatochi Masahiro, Ushida Yasunori, Yasuda Yoshinari, Yoshida Yasuko, Kawai Shun, Kato Ryuji, Nakashima Toru, Iwata Masamitsu, Kuwatsuka Yachiyo, Ando Masahiko, Hamajima Nobuyuki, Kondo Takaaki, Oda Hiroaki, Hayashi Mutsuharu, Kato Sawako, Yamaguchi Makoto, Maruyama Shoichi, Matsuo Seiichi, Honda Hiroyuki

PLOS ONE Vol. 10 ( 2 ) page： e0117591 2015.2

In vivo heat-stimulus-triggered osteogenesis. Reviewed

Ikuta Kunihiro, Urakawa Hiroshi, Kozawa Eiji, Hamada Shunsuke, Ota Takehiro, Kato Ryuji, Honda Hiroyuki, Kobayashi Takeshi, Ishiguro Naoki, Nishida Yoshihiro

INTERNATIONAL JOURNAL OF HYPERTHERMIA Vol. 31 ( 1 ) page： 58 - 66 2015.2

Characterization of time-course morphological features for efficientprediction of osteogenic potential in human mesenchymal stem cells. Reviewed

Matsuoka Fumiko, Takeuchi Ichiro, Agata Hideki, Kagami Hideaki, Shiono Hirofumi, Kiyota Yasujiro, Honda Hiroyuki, Kato Ryuji

BIOTECHNOLOGY AND BIOENGINEERING Vol. 111 ( 7 ) page： 1430 - 1439 2014.7

Label-free morphology-based prediction of multiple differentiation potentials ofhuman mesenchymal stem cells for early evaluation of intact cells. Reviewed

Sasaki Hiroto, Takeuchi Ichiro, Okada Mai, Sawada Rumi, Kanie Kei, Kiyota Yasujiro, Honda Hiroyuki, Kato Ryuji

PLOS ONE Vol. 9 ( 4 ) page： e93952 2014.4

The screening strategy of functional peptides derived from scaffold protein by peptide array and its possibility

Kanie Kei, Kato Ryuji

KAGAKU TO SEIBUTSU Vol. 52 ( 6 ) page： 361 - 370 2014

培養中の幹細胞品質評価 : 画像を用いた評価技術とその貢献 (特集再生医療実現に向けた幹細胞培養工学の最前線)

加藤竜司, 清田泰次郎, 備瀬竜馬

生物工学会誌 Vol. 92 ( 9 ) page： 495 - 499 2014

Orientation based segmentation for phase-contrast microscopic image of confluent cell Reviewed

Sasaki Kei, Yuasa Tetsuya, Sasaki Hiroto, Kato Ryuji

PROCEEDINGS OF THE ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY page： 3323 - 3326 2013.10

Screening of peptide ligands that bind to the Fc region of IgG using peptide array and its application to affinity purification of antibody Reviewed

Sugita Tomoya, Katayama Makoto, Okochi Mina, Kato Ryuji, Ichihara Takamitsu, Honda Hiroyuki

BIOCHEMICAL ENGINEERING JOURNAL Vol. 79 page： 33 - 40 2013.10

Analysing the substrate multispecificity of a proton-coupled oligopeptide transporter using a dipeptide library. Reviewed

Ito Keisuke, Hikida Aya, Kawai Shun, Vu Thi Tuyet Lan, Motoyama Takayasu, Kitagawa Sayuri, Yoshikawa Yuko, Kato Ryuji, Kawarasaki Yasuaki

NATURE COMMUNICATIONS Vol. 4 page： 2502 2013.9

Morphology-based prediction of osteogenic differentiation potential of humanmesenchymal stem cells. Reviewed

Matsuoka Fumiko, Takeuchi Ichiro, Agata Hideki, Kagami Hideaki, Shiono Hirofumi, Kiyota Yasujiro, Honda Hiroyuki, Kato Ryuji

PLOS ONE Vol. 8 ( 2 ) page： e55082 2013.2

Systematic analysis of a dipeptide library for inhibitor development using human dipeptidyl peptidase IV produced by a Saccharomyces cerevisiae expression system Reviewed

Hikida Aya, Ito Keisuke, Motoyama Takayasu, Kato Ryuji, Kawarasaki Yasuaki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 430 ( 4 ) page： 1217 - 1222 2013.1

Comprehensive Combination Analysis for Screening of Significant Peptide Epitopes Using a Slide Glass Type-Exclusive Peptide Array from Milk Protein Reviewed

Nakatochi Masahiro, Katayama Makoto, Kato Ryuji, Okochi Mina, Takase Tomokazu, Yoshida Yasuko, Kawase Mitsuo, Honda Hiroyuki

KAGAKU KOGAKU RONBUNSHU Vol. 39 ( 1 ) page： 40 - 45 2013

Publisher：The Society of Chemical Engineers, Japan

Based on the hypothesis that development of cow's milk allergy (CMA) in children can diagnosed from species of IgE epitope in patients, significant peptide epitope for IgE was analyzed by comprehensive combination analysis using the graphic assessment method. The Adaboost algorithm was used for classification of decision stump as weak classifier, and 6044060 models were constructed. Classification accuracies by 10-fol CV (10-fold cross-validation) were determined. Total distribution of accuracies was depicted and it was analyzed by Gaussian mixture distribution using the EM algorithm. It was found that the distribution could be divided into 5 sub-distributions by the Bayesian information criterion. The Gaussian sub-distributions were grouped into “significant sub-distributions” and “non-significant sub-distributions” and classifiers that belong to “significant distribution” were identified. Analysis of the assignment frequency of individual inputs assigned to the “significant distribution” identified 16 peptide epitopes with high assignment frequency, including aS1C30 and aS1C47 peptides. Since SERYLGYL from aS1C30 has already been reported as significant peptide epitope for CMA diagnose, our proposed method, CC-GAM, was suggested to be a useful tool for selection of significant epitopes.

DOI： 10.1252/kakoronbunshu.39.40

Web of Science

Scopus

Screening and application of cell-selective adhesion peptide for regenerative medical materials

Vol. 51 ( 3 ) page： 202 - 206 2013

Orientation based segmentation for phase-contrast microscopic image of confluent cell Reviewed

Sasaki Kei, Yuasa Tetsuya, Sasaki Hiroto, Kato Ryuji

2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) page： 3323 - 3326 2013

実用化に資する医薬品生産培養技術の課題と展開～抗体医薬品から細胞医薬品まで～)

長森英二, 加藤竜司, 清水一憲, 柳原佳奈

生物工学会誌 Vol. 91 ( 9 ) 2013

Combinational risk factors ofmetabolic syndrome identified by fuzzy neural network analysis of health-checkdata. Reviewed

Ushida Yasunori, Kato Ryuji, Niwa Kosuke, Tanimura Daisuke, Izawa Hideo, Yasui Kenji, Takase Tomokazu, Yoshida Yasuko, Kawase Mitsuo, Yoshida Tsutomu, Murohara Toyoaki, Honda Hiroyuki

BMC MEDICAL INFORMATICS AND DECISION MAKING Vol. 12 ( 1 ) page： 80 2012.8

Screening for silver nanoparticle-binding peptides by using a peptide array Reviewed

Kuboyama Masashi, Kato Ryuji, Okochi Mina, Honda Hiroyuki

BIOCHEMICAL ENGINEERING JOURNAL Vol. 66 page： 73 - 77 2012.7

Collagen type IV-specific tripeptides forselective adhesion of endothelial and smooth muscle cells. Reviewed

Kanie Kei, Narita Yuji, Zhao Yingzi, Kuwabara Fumiaki, Satake Makoto, Honda Susumu, Kaneko Hiroaki, Yoshioka Tomohiko, Okochi Mina, Honda Hiroyuki, Kato Ryuji

BIOTECHNOLOGY AND BIOENGINEERING Vol. 109 ( 7 ) page： 1808 - 1816 2012.7

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Papers - KATO, Ryuji