Updated on 2023/11/28

写真a

 
ZINCHENKO, Anatoly
 
Organization
Graduate School of Environmental Studies Department of Environmental Engineering and Architecture Functional Materials and Environment Associate professor
Graduate School
Graduate School of Environmental Studies
Undergraduate School
School of Engineering Architecture
School of Informatics and Sciences
Title
Associate professor
Contact information
メールアドレス
Homepage
http://www.urban.env.nagoya-u.ac.jp/suschem/index.html

Degree 2

  1. Doctor (Engineering) （ 2004.3   Nagoya University ） 

  2. Master (Chemistry) （ 2000.6   Moscow State University, Chemistry Department ） 

To the head of Degree.▲

Research Interests 4

  1. Recycling technologies

  2. Environmental cleaning

  3. Materials from waste biomass and plastics

  4. Nanotechnology

To the head of Research Interests.▲

Research Areas 5

  1. Nanotechnology/Materials / Polymer chemistry

  2. Nanotechnology/Materials / Nanometer-scale chemistry

  3. Environmental Science/Agriculture Science / Environmental load reduction and remediation

  4. Natural Science / Biophysics, chemical physics and soft matter physics

  5. Natural Science / Biophysics, chemical physics and soft matter physics

To the head of Research Areas.▲

Current Research Project and SDGs 2

  1. Materials from waste biomass and plastic

  2. Soil improvement

To the head of Current Research Project and SDGs.▲

Research History 4

  1. Nanyang Technological University   School of Biological Science   Visiting Associate Professor

    2016.9 - 2017.3

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    Country：Singapore

  2. Nagoya University   Graduate School of Environmental Studies   Associate professor

    2010.12

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    Country：Japan

  3. Nagoya University   Graduate School of Environmental Studies   Lecturer

    2007.1 - 2010.11

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    Country：Japan

  4. Kyoto University   School of Science   Research Fellow

    2004.4 - 2006.12

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    Country：Japan

To the head of Research History.▲

Education 2

  1. Nagoya University   Graduate School of Environmental Studies   Department of Environmental Engineering and Architecture

    2001.4 - 2004.3

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    Country： Japan

  2. Moscow State University   Graduate School, Division of Chemistry   Polymers

    1995.9 - 2000.6

To the head of Education.▲

Professional Memberships 4

  1. Japan Society of Civil Engineers

    2023.4

  2. The Japan Society of Polymer Science

    2011.4

  3. Chemical Society of Japan

    2007.4

  4. American Chemical Society

    2004.4

To the head of Professional Memberships.▲

Awards 1

  1. Chemical Society of Japan Annual Meeting Best Presentation Award

    2009.4   Chemical Society of Japan  

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    Country：Japan

To the head of Awards.▲
 

Papers 96

  1. Removal of Copper Ions Using a Waste Plastic-Derived Hydrogel Prepared via Microwave-assisted PET Aminolysis Reviewed

    Chan Kayee, Kawai Masami, Yamake Mina, Zinchenko Anatoly

    Gels   ( 874 )   2023.11

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Nanomaterials  

    Ubiquitous on Earth DNA and other nucleic acids are being increasingly considered as promising biomass resources. Due to their unique chemical structure, which is different from that of a more common carbohydrate biomass polymers, materials based on nucleic acids may exhibit new attractive characteristics. In this study, fluorescent nanoparticles (biodots) were prepared by a hydrothermal (HT) method from various nucleic acids (DNA, RNA, nucleotides, and nucleosides) to establish the relationship between the structure of precursors and fluorescent properties of biodots and to optimize conditions for preparation of the most fluorescent product. HT treatment of nucleic acids results in decomposition of sugar moieties and depurination/depyrimidation of nucleobases, while their consequent condensation and polymerization gives fluorescent nanoparticles. Fluorescent properties of DNA and RNA biodots are drastically different from biodots synthesized from individual nucleotides. In particular, biodots synthesized from purine-containing nucleotides or nucleosides show up to 50-fold higher fluorescence compared to analogous pyrimidine-derived biodots. The polymeric nature of a precursor disfavors formation of a bright fluorescent product. The reported effect of the structure of the nucleic acid precursor on the fluorescence properties of biodots should help designing and synthesizing brighter fluorescent nanomaterials with broader specification for bioimaging, sensing, and other applications.

    DOI： doi.org/10.3390/gels9110874

  2. Design and Synthesis of Functional Materials by Chemical Recycling of Waste Polyethylene Terephthalate (PET): Opportunities and Challenges Reviewed

    Kayee Chan, Anatoly Zinchenko

    Journal of Cleaner Production     2023.11

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Waste Management  

    The progressive accumulation of discarded plastic in the environment demands further development of waste management of plastic waste and conversion technologies of such waste to value-added materials. Recently, the conversion of plastic waste to functional materials via chemical recycling has attracted considerable attention. In this report, plastic waste (PET) was utilized for the preparation of a hydrogel-based catalyst via a cross-linking reaction of PET-derived oligo(terephthalamide)s followed by the electroless metallization. The polymeric matrix of PET-derived hydrogel plays multiple roles of (i) an adsorption media for noble metal ions such as Au3+ and Ag+, (ii) a reducing agent of Au3+ and Ag+ ions to Au0 and Ag0, and (iii) a matrix for the controlled growth of Au and Ag nanoparticles (AuNPs and AgNPs). The obtained hybrid hydrogels after metallization contained well-dispersed AuNPs and AgNPs of 6.1 ± 3.7 nm or 6.1 ± 1.4 nm size, respectively. The catalytic activities of the hybrid hydrogels with metal nanoparticles were studied in a model system of p-nitrophenol reduction in an aqueous solution. The hybrid materials of both Au@hydrogel and Ag@hydrogel were catalytically active for the reduction of p-nitrophenol, obeying the first-order kinetics. Importantly, the AuNPs or AgNPs in the hydrogel matrix preserved the original catalytic activity after multiple p-nitrophenol reduction reactions, showing a promising reusability of the catalysts. The proposed here approach aims to broaden the scope of conversion routes of plastic waste to value-added materials as well as to develop new types of polymeric matrices for templating and growth of metal nanoparticles for catalytic applications.

    DOI： 10.1016/j.jclepro.2023.139828

  3. Electrochemical extraction of methanol from lignin under mild conditions Reviewed International coauthorship

    Hibino Takashi, Kobayashi Kazuo, Zhou Dongwen, Chen Siyuan, Zinchenko Anatoly, Teranishi Shinya, Miyawaki Aki, Sawada Yoshiharu

    Applied Catalysis B: Environmental   Vol. 341   2023.10

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Applied Catalysis B: Environmental  

    We report an electrochemical approach to extract methanol from lignin with a maximum efficiency of 95% under mild conditions of ambient pressure and a temperature of 75 °C. Hydroxyl radicals were generated from water over a platinum-sputtered anode and attacked the syringyl and guaiacyl units of the lignin. Methoxy groups in the units were demethylated to methanol with a yield greater than 40% through the formation of hemiketal intermediates. The electro-oxidation was coupled to cathode reactions that generated hydrogen in a helium flow and electric power in an air flow. Another important aspect of this approach is that no extra energy or effort was required to separate methanol from the reaction system. This technology can accelerate the replacement of fossil organic resources with renewable biomass resources.

    DOI： 10.1016/j.apcatb.2023.123328

    Scopus

  4. Templating of catalytic gold and silver nanoparticles by waste plastic PET-derived hydrogel playing a dual role of a reductant and a matrix Reviewed

    Kayee Chan, Anatoly Zinchenko

    Waste Management   Vol. 164   page： 20 - 28   2023.6

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Waste Management  

    The progressive accumulation of discarded plastic in the environment demands further development of waste management of plastic waste and conversion technologies of such waste to value-added materials. Recently, the conversion of plastic waste to functional materials via chemical recycling has attracted considerable attention. In this report, plastic waste (PET) was utilized for the preparation of a hydrogel-based catalyst via a cross-linking reaction of PET-derived oligo(terephthalamide)s followed by the electroless metallization. The polymeric matrix of PET-derived hydrogel plays multiple roles of (i) an adsorption media for noble metal ions such as Au3+ and Ag+, (ii) a reducing agent of Au3+ and Ag+ ions to Au0 and Ag0, and (iii) a matrix for the controlled growth of Au and Ag nanoparticles (AuNPs and AgNPs). The obtained hybrid hydrogels after metallization contained well-dispersed AuNPs and AgNPs of 6.1 ± 3.7 nm or 6.1 ± 1.4 nm size, respectively. The catalytic activities of the hybrid hydrogels with metal nanoparticles were studied in a model system of p-nitrophenol reduction in an aqueous solution. The hybrid materials of both Au@hydrogel and Ag@hydrogel were catalytically active for the reduction of p-nitrophenol, obeying the first-order kinetics. Importantly, the AuNPs or AgNPs in the hydrogel matrix preserved the original catalytic activity after multiple p-nitrophenol reduction reactions, showing a promising reusability of the catalysts. The proposed here approach aims to broaden the scope of conversion routes of plastic waste to value-added materials as well as to develop new types of polymeric matrices for templating and growth of metal nanoparticles for catalytic applications.

    DOI： 10.1016/j.wasman.2023.03.037

    Scopus

  5. Reconstituted TAD-size chromatin fibers feature heterogeneous nucleosome clusters Reviewed International coauthorship

    Korolev Nikolay, Zinchenko Anatoly, Soman Aghil, Chen Qinming, Wong Sook Yi, Berezhnoy Nikolay V, Basak Rajib, van der Maarel Johan R. C., van Noort John, Nordenskiold Lars

    Scientific Reports   Vol. 12 ( 1 ) page： 15558   2022.9

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Scientific Reports  

    Large topologically associated domains (TADs) contain irregularly spaced nucleosome clutches, and interactions between such clutches are thought to aid the compaction of these domains. Here, we reconstituted TAD-sized chromatin fibers containing hundreds of nucleosomes on native source human and lambda-phage DNA and compared their mechanical properties at the single-molecule level with shorter ‘601’ arrays with various nucleosome repeat lengths. Fluorescent imaging showed increased compaction upon saturation of the DNA with histones and increasing magnesium concentration. Nucleosome clusters and their structural fluctuations were visualized in confined nanochannels. Force spectroscopy revealed not only similar mechanical properties of the TAD-sized fibers as shorter fibers but also large rupture events, consistent with breaking the interactions between distant clutches of nucleosomes. Though the arrays of native human DNA, lambda-phage and ‘601’ DNA featured minor differences in reconstitution yield and nucleosome stability, the fibers’ global structural and mechanical properties were similar, including the interactions between nucleosome clutches. These single-molecule experiments quantify the mechanical forces that stabilize large TAD-sized chromatin domains consisting of disordered, dynamically interacting nucleosome clutches and their effect on the condensation of large chromatin domains.

    DOI： 10.1038/s41598-022-19471-3

    Web of Science

    Scopus

    PubMed

  6. Aminolysis-assisted hydrothermal conversion of waste PET plastic to N-doped carbon dots with markedly enhanced fluorescence Reviewed

    Journal of Environmental Chemical Engineering   Vol. 10 ( 3 ) page： 107749   2022.6

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jece.2022.107749

    DOI： doi.org/10.1016/j.jece.2022.107749

    Web of Science

  7. Conversion of waste bottle PET to magnetic microparticles adsorbent for dye-simulated wastewater treatment Reviewed

    Chan Kayee, Zinchenko Anatoly

    Journal of Environmental Chemical Engineering   Vol. 10 ( 3 )   2022.6

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Environmental Chemical Engineering  

    Mass production and consequent accumulation of plastic wastes in the environment urges the development of technologies for the efficient plastic wastes utilization and valorization to materials and products to support circular economy. Here, we report a novel conversion of PET plastic to a magnetic microparticles adsorbent prepared by co-precipitation of Fe3O4 nanoparticles with oligomeric products of PET aminolysis. The obtained adsorbent represents highly water-dispersible oligo(terephthalamide) particles of several tens μm size embedding magnetic nanoparticles randomly distributed in the organic matrix. The PET-derived magnetic adsorbent was used for the rapid and facile magnetic separation of an anionic dye (Congo Red, CR) from dye simulated water samples. The adsorbent containing plenty of amine groups showed superb adsorption capacity for CR of ca. 780 mg/g which is pH dependent and optimal at pH 6.5. Furthermore, the microparticular, non-aggregative state of the adsorbent coupled with its magnetic functionality provided rapid saturation of the adsorbent with dye by ca. 70% of the equilibrium adsorption capacity within 5 min and possibility of instantaneous removal from solution by a magnet. The proposed here material design addresses simultaneously the problem of plastic wastes utilization and preparation of cost-effective and efficient adsorbents for environmental cleaning purposes.

    DOI： 10.1016/j.jece.2022.108055

    Web of Science

    Scopus

  8. Efficient Stabilization of Soil, Sand, and Clay by a Polymer Network of Biomass-Derived Chitosan and Carboxymethyl Cellulose Reviewed

    Anatoly Zinchenko, Takayuki Sakai, Kohki Morikawa, Masaki Nakano

    Journal of Environmental Chemical Engineering   Vol. 10 ( 1 )   2022.2

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Environmental Chemical Engineering  

    Biomass-derived polymers are being increasingly utilized as eco-friendly functional materials in fields ranging from medicine and food to agriculture and environmental engineering. In this report, we developed a novel efficient method for improvement of soil materials based on in situ gelation of a polyion complex formed by biomass-derived carboxymethyl cellulose (CMC) and chitosan (CS). Self-organized network of polymer films and microfibers assembled via electrostatic interactions between oppositely-charged polyions interconnects particles of soil material and imparts the resulted composite with a considerable mechanical strength. Treatment of soil even with a high water content (ca. 30%) by a mixture of CMC and CS at m(CMC + CS)/m(soil) ratio of ca. 1% is sufficient to gain up to 150 kPa compression strength that further increases up to ca. 1 MPa after drying. Similar reinforcement effect by CMC-CS complex was observed for sand, and much higher yield strengths were measured for clay. Mechanical properties of soil materials strengthened by CMC-CS complex depended on structure and stability of CMC-CS polyion network and controlled by the polymerization degrees of macromolecules and the charge ratio between them. Being composed entirely of biomass-derived polymers, the proposed soil treatment system is particularly attractive due to environmental friendliness and sustainability and it can be utilized not only for the soil improvement but also for the construction of functional platforms for soil pollution control and remediation.

    DOI： 10.1016/j.jece.2021.107084

    Scopus

  9. DNA-Chitosan Aerogels and Regenerated Hydrogels with Extraordinary Mechanical Properties Reviewed International coauthorship

    Postnova Irina, Sarin Sergey, Zinchenko Anatoly, Shchipunov Yury

    ACS Applied Polymer Materials   Vol. 4 ( 1 ) page： 663 - 671   2021.12

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：ACS Applied Polymer Materials  

    It has recently been shown that native ds-DNA and chitosan can coassemble without common phase separation and precipitation, forming a translucent homogeneous hydrogel. This simple approach consists of progressive charging of the polysaccharide through gradual acidification of a solution in the presence of DNA, which slowly strengthens the electrostatic interactions between them, ruling out fast and uncontrolled cooperative association, which is a well-known problem associated with coacervation. Homogeneous hydrogels thus fabricated demonstrated mechanical properties characteristic of quite strong physical hydrogels. Extraordinary mechanical strength and elasticity have been observed in aerogels prepared from an original hydrogel and also in hydrogels, which were restored by the rehydration of aerogels. Aerogels match highly cross-linked synthetic polyurethane foams despite DNA with chitosan being bound only via electrostatic interactions without using a toxic cross-linking agent. Owing to their biocompatibility, biodegradability, and available renewable resources, hydrogels and aerogels might replace typical synthetic polymers. The fabrication of bionanocomposites with luminescent, sensing, and photocatalytic functionalities by entrapping quantum dots, titania nanoparticles, and dyes demonstrates some possible applications.

    DOI： 10.1021/acsapm.1c01585

    Web of Science

    Scopus

  10. Conversion of waste bottles' PET to a hydrogel adsorbent via PET aminolysis Reviewed

    Kayee Chan, Anatoly Zinchenko

    Journal of Environmental Chemical Engineering   Vol. 9 ( 5 ) page： 106129   2021.10

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Environmental Chemical Engineering  

    To ensure sustainable use of natural resources and circulation of materials, efficient methods of waste plastic conversion into value chemicals and scenarios for utilization of the latter are increasingly demanded. Here, we propose a method of waste PET bottles conversion to cross-linked hydrogels through PET aminolysis using tri- and tetraamines as a method of plastic waste valorization. Water-soluble oligomeric products of PET aminolysis were cross-linked in water using diglycidyl ether to get mechanically stable hydrogels that show typical polyelectrolyte behavior of polycations. PET-derived hydrogels abundant with amino groups and aromatic moieties were tested as adsorbents for an anionic dye such as Congo Red, and their absorption capacity towards dye was found to be ca. 500 mg/g. Beside demonstrated here application of PET-derived hydrogels for water cleaning from an industrial dye, utilization of such hydrogel materials in fields of environment, agriculture, separation, etc. are also anticipated.

    DOI： 10.1016/j.jece.2021.106129

    Web of Science

    Scopus

  11. Fluorescent Nanoparticles Synthesized from DNA, RNA, and Nucleotides Reviewed International coauthorship

    Wang Maofei, Tsukamoto Masaki, Sergeyev Vladimir G., Zinchenko Anatoly

    Nanomaterials   Vol. 11 ( 9 ) page： 2265   2021.9

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Nanomaterials  

    Ubiquitous on Earth DNA and other nucleic acids are being increasingly considered as promising biomass resources. Due to their unique chemical structure, which is different from that of a more common carbohydrate biomass polymers, materials based on nucleic acids may exhibit new attractive characteristics. In this study, fluorescent nanoparticles (biodots) were prepared by a hydrothermal (HT) method from various nucleic acids (DNA, RNA, nucleotides, and nucleosides) to establish the relationship between the structure of precursors and fluorescent properties of biodots and to optimize conditions for preparation of the most fluorescent product. HT treatment of nucleic acids results in decomposition of sugar moieties and depurination/depyrimidation of nucleobases, while their consequent condensation and polymerization gives fluorescent nanoparticles. Fluorescent properties of DNA and RNA biodots are drastically different from biodots synthesized from individual nucleotides. In particular, biodots synthesized from purine-containing nucleotides or nucleosides show up to 50-fold higher fluorescence compared to analogous pyrimidine-derived biodots. The polymeric nature of a precursor disfavors formation of a bright fluorescent product. The reported effect of the structure of the nucleic acid precursor on the fluorescence properties of biodots should help designing and synthesizing brighter fluorescent nanomaterials with broader specification for bioimaging, sensing, and other applications.

    DOI： 10.3390/nano11092265

    Web of Science

    Scopus

    PubMed

  12. Metal Ions Sensing by Biodots Prepared from DNA, RNA, and Nucleotides. Reviewed International coauthorship International journal

    Maofei Wang, Masaki Tsukamoto, Vladimir G Sergeyev, Anatoly Zinchenko

    Biosensors   Vol. 11 ( 9 ) page： 333   2021.9

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Nucleic acids that exhibit a high affinity toward noble and transition metal ions have attracted growing attention in the fields of metal ion sensing, toxic metal ion removal, and the construction of functional metal nanostructures. In this study, fluorescent nanoparticles (biodots) were synthesized from DNA, RNA, and RNA nucleotides (AMP, GMP, UMP, and CMP) using a hydrothermal (HT) method, in order to study their metal ion sensing characteristics. The fluorescent properties of biodots differ markedly between those prepared from purine and pyrimidine nucleobases. All biodots demonstrate a high sensitivity to the presence of mercury cations (Hg2+), while biodots prepared from DNA, RNA, and guanosine monophosphate (GMP) are also sensitive to Ag+ and Cu2+ ions, but to a lesser extent. The obtained results show that biodots inherit the metal ion recognition properties of nucleobases, while the nucleobase composition of biodot precursors affects metal ion sensitivity and selectivity. A linear response of biodot fluorescence to Hg2+ concentration in solution was observed for AMP and GMP biodots in the range 0-250 μM, which can be used for the analytic detection of mercury ion concentration. A facile paper strip test was also developed that allows visual detection of mercury ions in solutions.

    DOI： 10.3390/bios11090333

    Web of Science

    Scopus

    PubMed

  13. Adsorptive Removal of Heavy Metal Ions, Organic Dyes, and Pharmaceuticals by DNA-Chitosan Hydrogel Invited Reviewed

    Chan K., Morikawa K., Shibata N., Zinchenko A.

    Gels   Vol. 7 ( 3 ) page： 112   2021.8

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/gels7030112

    DOI： 10.3390/gels7030112

    Scopus

    Other Link： https://www.mdpi.com/2310-2861/7/3/112/pdf

  14. DNA-Chitosan Hydrogels: Formation, Properties, and Functionalization with Catalytic Nanoparticles Reviewed International coauthorship

    Morikawa K., Masubuchi Y., Shchipunov Y., Zinchenko A.

    ACS Applied Bio Materials   Vol. 4   page： 1823 - 1832   2021.1

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    Authorship：Last author,　Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acsabm.0c01533

    Scopus

  15. Internal Motion of Chromatin Fibers Is Governed by Dynamics of Uncompressed Linker Strands. Reviewed International coauthorship

    Biophysical Journal   Vol. 119 ( 11 ) page： 2326 - 2334   2020.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bpj.2020.10.018

    Web of Science

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  16. Compaction and self-association of megabase-sized chromatin are induced by anionic protein crowding Reviewed International coauthorship

    Zinchenko Anatoly, Chen Qinming, Berezhnoy Nikolay V, Wang Sai, Nordenskiold Lars

    Sort Matter   Vol. 16 ( 18 ) page： 4366 - 4372   2020.5

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1039/d0sm00162g

    Web of Science

    Scopus

    PubMed

  17. Amino Acid Sequence of Oligopeptide Causes Marked Difference in DNA Compaction and Transcription Reviewed

    Zinchenko Anatoly, Hiramatsu Hiroyuki, Yamaguchi Hideaki, Kubo Koji, Murata Shizuaki, Kanbe Toshio, Hazemoto Norio, Yoshikawa Kenichi, Akitaya Tatsuo

    Biophysical Journal   Vol. 116 ( 10 ) page： 1836 - 1844   2019.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bpj.2019.04.010

    Web of Science

    Scopus

    PubMed

  18. Small DNA Additives to Polyelectrolyte Multilayers Promote Formation of Ultrafine Gold Nanoparticles with Enhanced Catalytic Activity Invited Reviewed

    Nagahama C., Zinchenko A.

    Colloid and Polymer Science   Vol. 297   page： 363–369   2019.3

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00396-018-4432-6

  19. Hybrid porous magnetic bentonite-chitosan beads for selective removal of radioactive cesium in water. Reviewed

    Wang K, Ma H, Pu S, Yan C, Wang M, Yu J, Wang X, Chu W, Zinchenko A

    Journal of Hazardous Materials   Vol. 362   page： 160 - 169   2019.1

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jhazmat.2018.08.067

    Scopus

    PubMed

  20. Encapsulation of Long Genomic DNA into a Confinement of a Polyelectrolyte Microcapsule: A Single-Molecule Insight Reviewed

    Zinchenko Anatoly, Inagaki Eisuke, Murata Shizuaki

    ACS OMEGA   Vol. 4 ( 1 ) page： 458 - 464   2019.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acsomega.8b02865

    Web of Science

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  21. A highly efficient magnetic chitosan “fluid” adsorbent with a high capacity and fast adsorption kinetics for dyeing wastewater purification Reviewed

    Ma Hui, Pu Shengyan, Hou Yaqi, Zhu Rongxin, Zinchenko Anatoly, Chu Wei

    Chemical Engineering Journal   Vol. 345   page： 556 - 565   2018.8

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier B.V.  

    A novel magnetic fluid adsorbent (magnetic chitosan “fluid” MCF) was prepared via a one-step in situ co-precipitation procedure using inexpensive and environmentally friendly chitosan (CS) and iron precursor. The resultant ultrafine colloid was characterized using transmission electron microscopy (TEM), X-ray powder diffraction (XRD), thermogravimetric analysis (TGA), and Fourier transform infrared spectroscopy (FTIR). The sorption and desorption characteristics of the composite were studied using a common Congo Red (CR) anionic dye to evaluate the suitability of the MCF for anionic dye wastewater purification. As an important advantage, the dye adsorption could be achieved in a wide alkaline pH range and reached the equilibrium within 5 min demonstrating the superior properties of our material compared the previously reported CS-based adsorbents. The adsorption obeyed the Langmuir isotherm model with the remarkable maximum adsorption capacity of approx. 1700 mg/g for CR under neutral pH. NaOH treatment was utilized to desorb and regenerate MCF, while the removal rate still remained above 90% after recycling five times, demonstrating that the MCF could be employed for repeated use without significant capacity loss. MCF could be readily separated from water within 30 s under a low magnetic field (&lt
    0.035 T). Overall, the ultrafine colloidal state of the synthesized MCF enabled a rapid pollutant uptake, high adsorption capacity, and reusability. The above characteristics of MCF and its environmentally friendly composition make it a very promising material for practical dyeing wastewater purification.

    DOI： 10.1016/j.cej.2018.03.115

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    Scopus

  22. Efficient prevention of nanomaterials transport in the porous media by treatment with polyelectrolytes Reviewed

    Soenaryo T., Murata S., Zinchenko A.

    Chemosphere   Vol. 210   page： 567-576   2018.8

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.chemosphere.2018.07.037

  23. Compaction of Single Molecule Megabase-Long Chromatin under the Influence of Macromolecular Crowding Reviewed

    Zinchenko A., Berezhnoy N., Chen Q., Nordenskiöld L.

    Biophysical Journal   Vol. 114   page： 2326–2335   2018.5

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bpj.2018.04.012

  24. Stretch and Dynamics of Single Chromatin Molecules Confined in Nano-fluidic Channels

    William M. Rosencrans, Fan Liu, Nikolay V. Berezhnoy, Anatoly Zinchenko, Lars Nordenskiold, Johan R. C. van der Maarel

    BIOPHYSICAL JOURNAL   Vol. 114 ( 3 ) page： 599A - 599A   2018.2

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：CELL PRESS  

    DOI： 10.1016/j.bpj.2017.11.3273

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  25. Removal of Carbon Nanomaterials by Co-Precipitation with Chitosan: A Facile Method for Water Pre-Treatment Reviewed

    Soenaryo T., Zinchenko A., Murata S.

    Environmental Science: Water Research Technolology   Vol. 4   page： 265-271   2018.1

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1039/C7EW00283A

  26. Single-Molecule Compaction of Megabase-Long Chromatin Molecules by Multivalent Cations Reviewed

    Zinchenko A., Berezhnoy N., Wang S, Rosencrans W., Korolev N., van der Maarel J., Nordenskiöld L.

    Nucleic Acids Research   Vol. 2   page： 635-649   2018.1

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/nar/gkx1135

  27. Formation of Multi-Layered Chitosan Honeycomb Spheres via Breath-Figure-Like Approach in Combination with Co-Precipitation Processing Reviewed

    Ma H., Pu S.Y., Ma J., Yan C., Zinchenko A., Pei X., Chu W.

    Materials Letters   Vol. 211   page： 91-95   2018.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.matlet.2017.09.091

  28. DNA-based materials as chemical reactors for synthesis of metal nanoparticles

    Zinchenko A., Sergeyev V. G.

    Polymer Science Series C   Vol. 59 ( 1 ) page： 18-28   2017.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1134/S1811238217010155

    Web of Science

  29. Novel highly porous magnetic hydrogel beads composed of chitosan and sodium citrate: an effective adsorbent for the removal of heavy metals from aqueous solutions Reviewed

    Pu S.Y., Ma H., Zinchenko A., Chu W.

    Environmental Science and Pollution Research   Vol. 24 ( 19 ) page： 16520-16530   2017.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s11356-017-9213-0

  30. Photoinduced Fusion of Lipid Bilayer Membranes Reviewed

    Suzuki Y., Nagai K., Zinchenko A., Hamada T.

    Languir   Vol. 33 ( 10 ) page： 2671-2676   2017.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acs.langmuir.7b00448

  31. An efficient heterogeneous fenton catalyst based on modified diatomite for degradation of cationic dye simulated wastewater Reviewed

    Pu S.Y., Xiang C., Zhu R., Ma H., Zinchenko A., Chu W.

    Desalination Water Treat.   Vol. 79   page： 378-385   2017

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.5004/dwt.2017.20824

  32. 大学の廃棄物のキャンパスマインとしての活用への提言（１） ─ 名古屋大学における廃試薬の調査に基づく考察 Reviewed

    ジンチェンコ アナトーリ, 竹田 裕哉, 三品 太志, 村田 静昭, 陳 寧

    環境と安全   Vol. 7   page： 17   2016.4

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  33. Gold Nanoparticles in DNA-Based Multilayer Films: Synthesis, Size Control, and Influence of the Multilayer Structure on Au NP Catalytic Properties Reviewed

    Zinchenko A, Nagahama C, Murata. S

    ChemNanoMat   Vol. 2016 ( 2 ) page： 125-132 - 132   2016.1

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY-V C H VERLAG GMBH  

    A method to prepare DNA-based multilayered microcapsules as a host matrix for synthesizing ultrasmall gold nanoparticles of 2-4 nm in size is presented. Utilizing the intrinsic affinity of DNA for transition metal ions, ionic gold was first efficiently concentrated inside the DNA-based multilayers assembled on a CaCO3 sacrificial template. Further reduction of ionic gold inside the multilayers resulted in the formation of high-density, well-dispersed 2-4 nm gold nano-particles distributed evenly and exclusively inside the polyelectrolyte multilayers. Metallized multilayers containing ultrafine gold nanoparticles showed a good performance in catalytic reduction of nitroaromatic compounds and the catalytic activity of gold nanoparticles was enhanced with a decrease of host multilayer thickness. The influence of the multilayer structure and composition on size and catalytic activity of gold nanoparticles is discussed.

    DOI： 10.1002/cnma.201600012

    Web of Science

  34. DNA Conformational Behavior and Compaction in Biomimetic Systems: Toward Better Understanding of DNA Packaging in Cel Reviewed

    Zinchenko A.

    Adv. Colloid. Interface Sci.   Vol. 2016 ( 232 ) page： 70-79   2016.1

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    Authorship：Lead author   Language：English  

    DOI： 10.1016/j.cis.2016.02.005

  35. Decoration of DNA scaffold by gold nanoparticles formed in aqueous solutions Reviewed

    Lopatina L.I., Karpushkin E.A., Zinchenko A., Sergeyev V.G.

    Mendeleyev Comm.   Vol. 26   page： 291‐292   2016

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.mencom.2016.07.007

  36. Fabrication of Bimetallic Core-Shell and Alloy Ag-Au Nanoparticles on a DNA Template Reviewed

    Taniguchi S., Zinchenko A., Murata. S.

    Chem.Lett.   Vol. 45   page： 610‐611   2016

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1246/cl.160180

  37. Divalent cation shrinks DNA but inhibits its compaction with trivalent cation Reviewed

    Tongu C., Kenmotsu T., Yoshikawa Y., Zinchenko A., Chen N., Yoshikawa K.*

    J. Chem. Phys.   Vol. 144   page： 205101   2016

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1063/1.4950749

  38. Metallization of DNA Hydrogel - Application of Soft Matter Host for Preparation and Nesting of Catalytic Nanoparticles Reviewed

    Zinchenko A., Che Y., Taniguchi S., Lopatina L.I., Sergeyev V.G.,Murata S.

    J.Nanopart. Res.   Vol. 18   page： 179   2016

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s11051-016-3480-4

  39. Suggestion on application of campus wastes as valuable resources, a campus mine (1) — Study and discussion on chemical wastes of Nagoya University Reviewed

    Zinchenko Anatoly, Takeda Yuuya, Mishina Taiji, Murata Shizuaki, Chen Ning

    Journal of Environment and Safety   Vol. 7 ( 1 ) page： 17 - 23   2016

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    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Academic Consociation of Environmental Safety and Waste Management, Japan  

    In order to reduce the amount of wastes and to promote their reuse and recycle, valuable materials, such as minor and noble metals and their compounds, which were included in disposed reagents generated by academic activities in Nagoya University during the period of 2009 to 2012, have been investigated. Closed up herein were many problems, such as dumping hazardous materials without special care, the absence of a recycling system of valuable chemical wastes and wasting research budgets due to disposing reagents without opening bottles. In addition, establishment of a chemical library of minor elements as well as an exchanging system of information about chemical stocks in each laboratory for the purpose of their sharing.

    DOI： 10.11162/daikankyo.15g1101

    CiNii Research

  40. Size Dependent Catalytic Activity of Gold Nanoparticles in DNA Hydrogels Reviewed

    Zinchenko A. Taniguchi S., Murata. S.

    Macromolecular Symposia   Vol. 2015 ( 129 ) page： 106-111   2015.12

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/masy.201500062

  41. DNAの資源化

    ジンチェンコ アナトーリ

    化学と工業   Vol. 68 ( 9 ) page： 804-805   2015.9

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  42. Solubilization of MWCNT by DNA and Construction of DNA-MWCNT Hybrid Hydrogels Reviewed

    Zinchenko A, Taki Y, Sergeyev V.G, Murata S

    Nanomaterials   Vol. 2015 ( 5 ) page： 270-283   2015.2

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  43. Uptake of Aromatic Compounds by DNA: Toward the Environmental Application of DNA for Cleaning Water Reviewed

    Fernández-Solis C, Kuroda Y, Zinchenko A, Murata S

    Colloids Surf., B.   Vol. 2015 ( 129 ) page： 146–153   2015.2

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  44. Compaction of Double-Stranded DNA by Negatively Charged Proteins and Colloids Reviewed

    Zinchenko A, Yoshikawa K

    Curr. Opin. Colloid Interface Sci.   Vol. 2015 ( 20 ) page： 60-65   2015.1

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  45. Control of a Catalytic Activity of Gold Nanoparticles Embedded in DNA Hydrogel by Swelling/Shrinking the Hydrogel's Matrix Reviewed

    Che Y, Zinchenko A, Murata S

    J. Colloid Interface Sci.   Vol. 2015 ( 445 ) page： 364-370   2015.1

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  46. Entrapment and Removal of Carbon Nanotubes and Fullerenes by Co-Precipitation with Calcium Carbonate Beads Reviewed

    Pu S.Y, Zinchenko A.A, Chen N, Murata S

    ACS Sustainable Chem. Eng.   Vol. 2014 ( 2 ) page： 2275-2282   2014.9

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    Language：English   Publishing type：Research paper (scientific journal)  

  47. Crowding by anionic nanoparticles causes DNA double-strand instability and compaction Reviewed

    Zinchenko, A.; Tsumoto, K.; Murata, S.; Yoshikawa, K.

    J. Phys. Chem.   Vol. 118 ( 5 ) page： 1256-1262   2014

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  48. Photochemical metallization to fabricate DNA-templated gold nanorings Reviewed

    Pu S.Y, Zinchenko A.A., Qina L., Xua M., M. Xu., Murata S.

    Mater. Lett.   Vol. 130   page： 168-171   2014

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  49. DNA Hydrogel as a Template for Synthesis of Ultrasmall Gold Nanoparticles for Catalytic Applications Reviewed

    Zinchenko A. A., Miwa, Y., Lopatina L.I., Sergeyev V.G., Murata S.

    ACS Appl. Mater. Interfaces   Vol. 6 ( 5 ) page： 3226–3232.   2014

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  50. Size Control of Gold Nanoparticles Synthesized in a DNA Hydrogel Reviewed

    Miwa, Y, Zinchenko A. A, Lopatina L.I, Sergeyev V.G, Murata S

    Polym. Int.   Vol. 63 ( 9 ) page： 1566-1571   2014

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  51. Extraction of Noble and Rare-Earth Metals from Aqueous Solutions by DNA Cross-Linked Hydrogel Reviewed

    Maeda Y., Zinchenko A. A., Murata S.

    ChemPlusChem   Vol. 78 ( 7 ) page： 619-622   2013

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  52. Entrapping of Fullerenes, Nanotubes, and Inorganic Nanoparticles by a DNA-Chitosan Complex: A Method for Nanomaterials Removal Reviewed

    Zinchenko A. A, Maeda N, Pu S.Y, Murata S

    Environ. Sci. Technol.   Vol. 47 ( 9 ) page： 4489-4496   2013

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  53. Templating of inorganic nanomaterials by biomacromolecules and their assemblies Invited Reviewed

      Vol. 54 ( 7 ) page： 1048-1055   2012

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    Authorship：Lead author   Language：English  

  54. Facile Control of DNA-Templated Inorganic Nanoshell Size Reviewed

      Vol. 12   page： 635-641   2012

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  55. Photochemical Modulation of DNA Conformation by Organic Dications Reviewed

    Zinchenko A. A, Tanahashi M, Murata S

    ChemBioChem   Vol. 13   page： 105-111   2012

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  56. Thiol-Mediated Anchoring of Silver Cations to DNA for Construction of Nanofibers on DNA Scaffold Reviewed

    Zinchenko A. A, Chen N, Baigl D, Lopatina L, Sergeyev V. G

    Biomacromolecules   Vol. 13 ( 6 ) page： 1787-1793   2012

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    Language：English   Publishing type：Research paper (scientific journal)  

  57. A Facile Method for the Assessment of DNA Damage Induced by UV-Activated Nanomaterials Reviewed

    Yamazaki Y, Zinchenko A. A, Murata S

    Nanoscale   Vol. 3 ( 7 ) page： 2909-2915   2011

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    Language：English   Publishing type：Research paper (scientific journal)  

  58. Effects of Cationic and Anionic Nanoparticles on the Stability of the Secondary Structure of DNA Reviewed

    Kamata H., Zinchenko A. A., Murata S.

    Colloid Polym. Sci.   Vol. 289   page： 1329-1335   2011

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    Language：English   Publishing type：Research paper (scientific journal)  

  59. Conformational behavior of DNA-templated CdS inorganic nanowiren of Hollow Meshed Inorganic Nanoshells Reviewed

    Pu S. Y., Zinchenko A. A., Murata S.

    Nanotechnology   Vol. 22   page： 375604   2011

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    Language：English   Publishing type：Research paper (scientific journal)  

  60. Facile Control of DNA-Templated Inorganic Nanoshell Size Reviewed

    Pu S. Y., Zinchenko A. A., Murata S.

    J. Nanosci. Nanotechnol.     page： in press   2011

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    Language：English   Publishing type：Research paper (scientific journal)  

  61. DNA-Assisted "Double-Templating" Approach for the Construction of Hollow Meshed Inorganic Nanoshells Reviewed

    Pu S. Y., Zinchenko A. A., Murata S.

    Langmuir   Vol. 27 ( 8 ) page： 5009-5013   2011

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    Language：English   Publishing type：Research paper (scientific journal)  

  62. DNA Compaction on Histone Mimics Prepared from Silica Nanoparticles

    TAKENAKA Toshio, ZINCHENKO Anatoly A., YOSHIKAWA Kenichi, MURATA Shizuaki

      Vol. 39 ( 1 ) page： 72 - 73   2010.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    CiNii Research

  63. DNA Compaction on Histone Mimics Prepared from Silica Nanoparticles Reviewed

    Takenaka T., Zinchenko A. A., Yoshikawa K., Murata S.

    Chemistry Letters   Vol. 39   page： 72-73   2010

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  64. Quantum dot probes for observation of single molecule DNA and a synthetic polyelectrolyte higher-order structure Reviewed

    Chen N., Zinchenko A. A., Yamazaki Y., Yoshikawa Y., Murata S., Yoshikawa K.

    Soft Matter   Vol. 6   page： 2834 - 2841   2010

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  65. Roles of Mono- and Divalent Cations in DNA Compaction Induced by Histone-Mimic Nanoparticles Reviewed

    Takenaka T., Zinchenko A. A., Yoshikawa K., Murata S.

    Bulletin of the Chemical Society of Japan   Vol. 83   page： 643-650   2010

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  66. Thermo-Switching of the Conformation of Genomic DNA in Solutions of Poly(N-isopropylacrylamide) Reviewed

    Chen N, Zinchenko A. A, Kidoaki S, Murata S, Yoshikawa K

    Langmuir   Vol. 26 ( 5 ) page： 2995-2998   2010

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  67. *Application of DNA condensation for removal of mercury ions from aqueous solutions Reviewed

    Zinchenko A. A, Sakai H, Matsuoka S, Murata S

    Journal of Hazardous Materials   Vol. 168 ( 1 ) page： 38-43   2009

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    Language：English   Publishing type：Research paper (scientific journal)  

  68. Removal of heavy metal ions from aqueous solutions by complexation with DNA and precipitation with cationic surfactant Reviewed

    Sakai H., Matsuoka S., Zinchenko A. A., Murata S.

    Colloids Surf., A.   Vol. 347   page： 210–214   2009

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  69. Assessment of the DNA damage using the fluorescence microscope Reviewed

    Yamazaki Y., Zinchenko A. A., Murata S.

    Nucleic Acids Symp. Ser.   Vol. 53   page： 47-48   2009

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  70. ATP-induced shrinkage of DNA with MukB protein and MukBEF complex of Escherichia coli Reviewed

    Chen N, Zinchenko A.A, Yoshikawa Y, Araki S, Adachi S, Yamazoe M, Hiraga S, Yoshikawa K

    Journal of Bacteriology   Vol. 190 ( 10 ) page： 3731-3737   2008

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    Language：English   Publishing type：Research paper (scientific journal)  

    Fluorescence microscopic observation on individual T4 DNA molecules revealed that MukBEF complex (bacterial condensin) and its subunit MukB (a member of SMC superfamily) homodimer of Escherichia coli shrunk markedly large DNA molecules in the presence of hydrolysable ATP. Contrary, in the presence of ADP or ATP-γS, the conformation of DNA was almost not changed. This suggests that the ATPase activity of subunit MukB is essential to shrink large DNA molecules. Stretching experiment on the shrunken DNA in the presence of ATP and MukBEF indicated cross bridging interaction between DNA molecules.

  71. Photochemical Metallization of DNA Reviewed

    Zinchenko A. A, Chen N, Murata S

    Chemistry Letters   Vol. 37   page： 1096-1097   2008

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    Language：English   Publishing type：Research paper (scientific journal)  

    We have shown that upon UV irradiation of silver(I) ion solutions containing alcohol as reduction agents, metal nanoparticles are grown on a DNA polymer chain. This metallization is independent of the DNA double-helicity and is controlled by the chemical structure of alcohol as well as by the wavelength of the light source.

  72. Conformational Behavior of Giant DNA through Binding with Ag+ and Metallization Reviewed

    Zinchenko A. A., Baigl D, Chen N., Pyshkina O. A., Endo K., Sergeyev V. G., Yoshikawa K.

    Biomacromolecules   Vol. 9   page： 1981-1987   2008

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  73. Single-Molecule Observations of Giant DNA and Synthetic Polyelectrolyte by Labeling with Semiconductor "Quantum Dots" Reviewed

    Chen N., Yamazaki Y., Zinchenko A., Yoshikawa Y., Murata S., Yoshikawa K.

    Proceedings of International Symposium on Micro-Nano Mechatronics and Human Science     page： 140-144   2008

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    Authorship：Lead author   Language：English  

  74. A Novel Type Cationic Silica Nanoparticles and its Potential Application in Biomedicine Reviewed

    Li L., Takenaka T., Zinchenko A., Chen N., Ma Y., Yoshikawa K.

    Proceedings of International Conference on Bioinformatics and Biomedical Engineering (ICBBE) 2008     page： 1539-1542   2008

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    Language：English  

  75. Transcription of Giant DNA Complexed with Cationic Nanoparticles as a Simple Model of Chromatin Reviewed

    Zinchenko A. A., Luckel F., Yoshikawa K.

    Biophysical Journal   Vol. 92   page： 1318-1325   2007

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  76. Dynamic Conformational Behavior and Molecular Interaction Discrimination of DNA/Binder Complexes by Single-Chain Stretching in a MicroDevice Reviewed

    Huang W.-H., Zinchenko A. A., Pawlak C., Chen Y., Baigl D.

    ChemBioChem   Vol. 8 ( 15 ) page： 1771-1774   2007

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    Language：English   Publishing type：Research paper (scientific journal)  

  77. Visualization of Different Pathways of DNA Release from Interpolyelectrolyte Complex Reviewed

    Ayoubi M. A., Zinchenko A. A., Philippova O. E, Khokhlov A. R., Yoshikawa K.

    Journal of Physical Chemistry B   Vol. 111   page： 8378-8378   2007

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    Language：English   Publishing type：Research paper (scientific journal)  

    Fluorescence microscopy is used for visualizing the release of double-stranded DNA from its interpolyelectrolyte complex with positively charged poly(allylamine hydrochloride) though exchange reaction with added polyanion, poly(sodium styrenesulfonate). The switching of pathway of DNA release is due to the screening of electrostatic repulsion in charged sequences of naked DNA and the decrease of the osmotic pressure of counterions.

  78. Single-Chain Compaction of Long Duplex DNA by Cationic Nanoparticles: Modes of Interaction and Comparison with Chromatin Reviewed

    Zinchenko A. A, Sakaue T, Araki S, Yoshikawa K, Baigl D

    Journal of Physical Chemistry B   Vol. 111   page： 3019 -3031   2007

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    Language：English   Publishing type：Research paper (scientific journal)  

    The compaction of long duplex DNA by cationic nanoparticles (NP) used as a primary model of histone core particles has been investigated. We have systematically studied the effect of salt concentration, particle size, and particle charge by means of single-molecule observations-fluorescence microscopy (FM) and transmission electron microscopy (TEM)-and molecular dynamics (MD) simulations. We have found that the large-scale DNA compaction is progressive and proceeds through the formation of beads-on-a-string structures of various morphologies. The DNA adsorbed amount per particle depends weakly on NP concentration but increases significantly with an increase in particle size and is optimal at an intermediate salt concentration. Three different complexation mechanisms have been identified depending on the correlation between DNA and NPs in terms of geometry, chain rigidity, and electrostatic interactions: free DNA adsorption onto NP surface, DNA wrapping around NP, and NP collection on DNA chain.

  79. Compaction of DNA on nanoscale three-dimensional templates Invited

    Zinchenko A. A., Chen N.

    Journal of Physics: Condensed Matter   Vol. 18   page： R453-R480   2006

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    Authorship：Lead author   Language：English  

  80. Na+ more strongly inhibits DNA compaction by spermidine (3+) than K+ Reviewed

    Hibino K, Yoshikawa Y, Murata S, Saito T, Zinchenko A. A, Yoshikawa K

    Chemical Physics Letters   Vol. 426   page： 405-409   2006

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  81. Probing Biopolymer Conformation by Metallization with Noble Metals Reviewed

    Chen N, Zinchenko A. A, Yoshikawa K

    Nanotechnology   Vol. 17   page： 5224-5232   2006

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    Language：English   Publishing type：Research paper (scientific journal)  

  82. *Compaction of single-chain DNA by histone-inspired nanoparticles Reviewed

    Zinchenko A. A., Yoshikawa K., Baigl D

    Physical Review Letters   Vol. 95 ( 22 ) page： 228101   2005

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  83. Na+ Shows a Markedly Higher Potential than K+ in DNA Compaction in a Crowded Environment Reviewed

    Zinchenko A. A., Yoshikawa K.

    Biophys. J.   Vol. 88(6)   page： 4118-4123   2005

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  84. DNA-templated silver nanorings Reviewed

    Zinchenko A. A., Yoshikawa K., Baigl D.

    Adv. Mater.   Vol. 17 ( 23 ) page： 2820-2823   2005

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  85. How Does DNA Compaction Favor Chiral Selectivity with Cationic Species? Higher Selectivity with Lower Cationic Charge Reviewed

    Zinchenko A. A., Chen N., Murata S., Yoshikawa K.

    ChemBioChem   Vol. 6(8)   page： 1419-1422   2005

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  86. Specific Formation of Beads-on-a-Chain Structures on Giant DNA Using a Designed Polyamine Derivative Reviewed

    Chen N., Zinchenko A. A., Murata S., Yoshikawa K.

    J. Am. Chem. Soc.   Vol. 127   page： 10910-10916   2005

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    Language：English   Publishing type：Research paper (scientific journal)  

  87. DNA Compaction by the Divalent Cations: Structural Specificity Revealed by the Potentiality of the Designed Quaternary Diammonium Salts, Reviewed

    Zinchenko A. A., Sergeyev V. G., Yamabe K., Murata S., Yoshikawa K.

    ChemBioChem   Vol. 5 ( 3 ) page： 360-368   2004

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  88. Stereoisomeric Discrimination in DNA Compaction Reviewed

    Zinchenko A. A, Sergeyev V. G, Kabanov V. A, Murata S, Yoshikawa K

    Angewandte Chemie International Edition   Vol. 43 ( 18 ) page： 2378-2371   2004

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    Language：English   Publishing type：Research paper (scientific journal)  

  89. Controlling the Intrachain Segregation on a Single DNA Molecule Reviewed

    Zinchenko A. A., Sergeyev V. G., Murata S., Yoshikawa K.

    J. Am. Chem. Soc.   Vol. 125 ( 15 ) page： 4414 - 4415   2003

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  90. Mechanism of Interaction of DNA with Surfactants in Water-Alcohol Media and Structure of the Related Complexes Reviewed

    Sergeyev V. G., Pyshkina O. A., Zinchenko A. A., Zezin S. B., Zezin A. B., Kabanov V. A.

    Polymer Science, Seriya A   Vol. 45 ( 5 ) page： 814 - 822   2003

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    Language：English   Publishing type：Research paper (scientific journal)  

  91. Ascorbic acid induces a marked conformational change in long duplex DNA Reviewed

    Yoshikawa Y., Suzuki M., Chen N., Zinchenko A. A., Murata S., Kanbe T., Nakai T., Oana H., Yoshikawa K.

    European Journal of Biochemistry   Vol. 270 ( 14 ) page： 3101-3106   2003

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    Language：English   Publishing type：Research paper (scientific journal)  

  92. Secondary Structure of DNA is Recognized by Slightly Cross-Linked Cationic Hydrogel Reviewed

    Sergeyev V. G, Novoskoltseva O. A, Zinchenko O. A, Pyshkina O. A, Rogacheva V. B, Zezin A. B, Yoshikawa K, Kabanov V. A

    J. Am. Chem. Soc.   Vol. 124   page： 11324-11333   2002

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    Language：English   Publishing type：Research paper (scientific journal)  

  93. The secondary structure determines the character of DNA interaction with a slightly cross-linked cationic hydrogel Reviewed

    Sergeyev V. G, Novoskoltseva O. A, Zinchenko A. A, Pyshkina O. A, Rogacheva V. B, Zezin A. B, Kabanov V. A

    Doklady Physical Chemistry   Vol. 116   page： 218-222   2001

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  94. Interplay between Folding/Unfolding and Helix/Coil Transitions in Giant DNA Reviewed

    Mikhailenko S. V., Sergeyev V. G., Zinchenko A. A., Gallyamov M. O., Yaminsky I. V., Yoshikawa K.

    Biomacromolecules   Vol. 1 ( 4 ) page： 597-603   2000

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  95. DNA-surfactant complexes in a water/alcohol mixture Reviewed

    Zinchenko A. A, Sergeyev V. G, Pyshkina O. A

    Progress in Polymer and Colloid Science   Vol. 116   page： 21-25   2000

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  96. Interpolyelectrolyte Complexes Formed by DNA and Astramol TM Poly(propyleneimine) Dendrimers Reviewed

    Kabanov V. A, Sergeyev V. G, Pyshkina, O. A. Zinchenko A. A, Zezin A. B, Joosten J. G. H, Brackman J, Yoshikawa K

    Macromolecules   Vol. 33 ( 26 ) page： 9587-9593   2000

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▼display all

To the head of Papers.▲

Books 4

  1. 相分離生物学の全貌

    湊元 幹太, ジンチェンコ アナトーリ（ Role： Joint author ,  42. 細胞様構造と相分離：モデル実験によるアプローチ）

    東京化学同人  2020.11  （ ISBN:9784807913466 ）

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    Language：Japanese Book type：Dictionary, encyclopedia

  2. リアルタイム計測による生命現象の解析 (R&D SERIES)・バイオ世界における自己組織化を利用したナノ構造・鋳型技術の進展

    ジンチェンコ アナトーリ, 鎌田宏幸（ Role： Joint author）

    シーエムシー出版  2011.3 

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    Responsible for pages：127-134   Language：Japanese Book type：Dictionary, encyclopedia

  3. "Single DNA molecules: Compaction and decompaction" in DNA Interactions with Polymers and Surfactants, ed. Dias R.

    Zinchenko A. A., Pyshkina O. A., Lezov A. V., Sergeyev V. G., Yoshikawa K.（ Role： Joint author）

    Willey-VCH  2008 

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    Language：English

    In this chapter we overview studies dedicated to the compaction of DNA by surfactants, multivalent cations and polymers, as well as decompaction, at single DNA molecule level.

  4. "Nanostructures and organizations of compacted single chains of polyelectrolytes" in Polymeric nanostructures and their applications

    Zinchenko A. A., Baigl D., Yoshikawa K.（ Role： Joint author）

    American Scientific Publishers  2007 

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    Language：English

    In this chapter we describe how DNA molecule compaction approach can be used for preparation of well defined nanostructures. This review includes over 250 references on the procedures of DNA compaction and the nanostructures formation.

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Presentations 34

  1. 廃棄ポリオレフィンを用いた2段階水熱合成による多色カーボンドットの作製

    高橋 侑誠、陳 嘉儀、ジンチェンコ アナトーリ

    日本化学会秋季事業 第13回 CSJ化学フェスタ2023  2023.10.17  日本化学会

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    Event date： 2023.10

    Language：Japanese   Presentation type：Poster presentation  

    Venue：東京   Country：Japan  

    Other Link： https://festa.csj.jp/2023/

  2. Application of Self-Organized Interpolyelectrolyte Networks as Functional Materials: Reinforcement, Adsorption, and Templating International coauthorship International conference

    Zinchenko A., Wang Y., Chan K., Sakai T., Nakano M.

    13th International Symposium on Polyelectrolytes  2023.8.29  Czech Technical University

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    Event date： 2023.8 - 2023.9

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Prague   Country：Czech Republic  

    Other Link： http://isp2023.com/home/#invitation

  3. Design of functional materials from waste PET bottles via chemical recycling International conference

    K. Chan, A. Zinchenko

    7th Green and Sustainable Chemistry Conference  2023.5.24  Elsevier

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    Event date： 2023.5

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Dresden   Country：Germany  

  4. Design of adsorbent materials based on oligomeric products of waste PET bottles decomposition by aminolysis International conference

    K. Chan, A. Zinchenko

    2022 Fall American Chemical Society Meeting  2022.8.24  American Chemical Society

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    Event date： 2022.8

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Online   Country：United States  

  5. Assembly, fluorescent properties, and metal ion sensing characteristics of biodots synthesized from DNA, RNA, and nucleotides International conference

    A. Zinchenko, M. Wang

    Pacifichem 2021  2021.12.18  Pacific Basin Societies

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    Event date： 2021.12

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Online   Country：United States  

  6. Conversion of PET Bottles to Hydrogel Adsorbents via PET Aminolysis International conference

    K. Chan, A. Zinchenko

    6th Green and Sustainable Chemistry Conference  2021.11.18  Elsevier

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    Event date： 2021.11

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Online   Country：Japan  

  7. DNA-Chitosan Hydrogels: formation, properties, and environmental applications International coauthorship International conference

    Zinchenko A., Chan K., Morikawa K., Shchipunov Y.

    7th Congress of Federation of Asian Polymer Societies  2021.6.15  Federation of Asian Polymer Societies

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    Event date： 2021.6

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Vladivostok, Russia (Online)   Country：Japan  

  8. バイオマス由来の高分子材料の混合が地盤材料の変形・強度特性に及ぼす影響

    酒井崇之, 中野正樹, ジンチェンコアナトーリ

    令和2年度土木学会中部支部研究発表会  2021.3 

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    Event date： 2021.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  9. DNA-Chitosan Hydrogels for Environmental and Materials Science Applications International conference

    K. Morikawa, A. Zinchenko

    5th Green and Sustainable Chemistry Conference  2020.11.11  Elsevier

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    Event date： 2020.11

    Language：English   Presentation type：Poster presentation  

    Country：Japan  

  10. Preparation of complex gel from DNA and chitosan and its application as metal ion adsorption material

    Morikawa K., Zinchenko A.

    The 100th CSJ Annual Meeting 

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    Event date： 2020.3

    Language：English   Presentation type：Poster presentation  

    Country：Japan  

  11. Compaction of DNA and Chromatin under Influence of Neutral and Anionic Crowding Invited International coauthorship International conference

    Zinchenko A.

    Okinawa Colloids 2019 

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    Event date： 2019.11

    Language：English   Presentation type：Oral presentation (invited, special)  

    Venue：Okinawa, Japan   Country：Japan  

  12. Encapsulation of Long DNA into Polyelectrolyte Capsules International conference

    Zinchenko A., Inagaki E., Murata S.

    The 45th International Symposium on Nucleic Acids Chemistry 

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    Event date： 2018.11

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  13. Unimolecular compaction of megabase-long chromatin International conference

    Zinchenko A.

    Workshop on Polyelectrolytes in Chemistry, Biology and Technology 2018 

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    Event date： 2018.3

    Language：English   Presentation type：Oral presentation (general)  

    Country：Singapore  

  14. Application of DNA-Based Hydrogels and Multilayered Films for Templating of Inorganic Nanomaterials Invited International conference

    Zinchenko A.

    International Symposium on Polyelectrolytes 

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    Event date： 2016.6 - 2016.7

    Language：English   Presentation type：Oral presentation (invited, special)  

    Country：Russian Federation  

  15. Novel Applications of DNA in Fields of Environment and Nanomaterials

    Zinchenko A. A.

    International Symposium on EcoTopia Science 2011  

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    Event date： 2011.12

    Language：English   Presentation type：Oral presentation (invited, special)  

    Country：Japan  

  16. DNAを用いた二重鋳型法による中空ナノシェル構造創製 International conference

    ジンチェンコ　アナトーリ，蒲生彦，村田静昭

    ナノ学会第9回大会 

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    Event date： 2011.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  17. DNA スポンジを用いた水溶液中からの重金属イオン除去

    松岡紗緒里・酒井博臣・Zinchenko Anatoly・村田静昭

    第40中部化学関係学協会支部連合秋季大会 

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    Event date： 2009.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  18. Study on Interaction of DNA with Chiral Nanoparticles to Verify a Role of Molecular Chirality of Nanoscale Template in DNA Compaction International conference

    International Conference on Nanoscience and Technology "China Nano" 2009 

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    Event date： 2009.9

    Language：English   Presentation type：Poster presentation  

  19. 単一分子DNA金属化によりDNAー金属ナノ構造体の形成

    Zinchenko, Anatoly・陳　寧・Baigl, Damien・吉川　研一

    第89日本化学会第89春季年会 

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    Event date： 2009.3

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  20. Detection of Polymer Conformational Transition by Metallization with Noble Metals

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    Event date： 2008.11

    Language：English   Presentation type：Oral presentation (general)  

  21. Purification of Heavy Metal Ions from Aqueous Solutions by Incorporation into DNA-Surfactant Complexes International conference

    5th International Conference "Interfaces Against Pollution" (IAP 2008) 

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    Event date： 2008.6

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  22. A novel type cationic silica nanoparticles and its potential application in biomedicine

    Liu L.

    2nd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2008 

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    Event date： 2008.1

    Language：English   Presentation type：Oral presentation (general)  

    DOI： 10.1109/ICBBE.2008.714

    Scopus

  23. DNA-nanoparticles complexes as a simplest chromatin model

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    Event date： 2007.11

    Language：English   Presentation type：Oral presentation (invited, special)  

    ジンチェンコ アナトーリ

  24. Biomimetic DNA compaction by cationic nanoparticles International conference

    American Chemical Society 231st National Meeting and Exposition 

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    Event date： 2006.3

    Language：English   Presentation type：Oral presentation (general)  

  25. Compaction of Single-Chain DNA by Histone-Inspired Nanoparticles International conference

    European Polymer Congress 

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    Event date： 2005.6

    Language：English   Presentation type：Oral presentation (invited, special)  

  26. Compaction of DNA and Chromatin under Influence of Neutral and Anionic Crowding Invited

    Zinchenko A

    Okinawa Colloids 2019  2019.11.3 

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    Language：English   Presentation type：Oral presentation (invited, special)  

    Venue：Okinawa, Japan  

  27. A novel type cationic silica nanoparticles and its potential application in biomedicine International conference

    Liu L

    2nd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2008  2008.1.1 

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    Language：English   Presentation type：Oral presentation (general)  

  28. Application of DNA-Based Hydrogels and Multilayered Films for Templating of Inorganic Nanomaterials Invited

    Zinchenko A

    International Symposium on Polyelectrolytes  2016.6.30 

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    Language：English   Presentation type：Oral presentation (invited, special)  

  29. DNA-Chitosan Hydrogels for Environmental and Materials Science Applications

    K. Morikawa, A. Zinchenko

    5th Green and Sustainable Chemistry Conference  2020.11.10 

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    Language：English   Presentation type：Poster presentation  

  30. DNAを用いた二重鋳型法による中空ナノシェル構造創製

    ジンチェンコ アナトーリ, 蒲生彦, 村田静昭

    ナノ学会第9回大会  2011.6.2 

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    Language：Japanese   Presentation type：Oral presentation (general)  

  31. Encapsulation of Long DNA into Polyelectrolyte Capsules

    Zinchenko A, Inagaki E, Murata S

    The 45th International Symposium on Nucleic Acids Chemistry  2018.11.7 

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    Language：English   Presentation type：Oral presentation (general)  

  32. Novel Applications of DNA in Fields of Environment and Nanomaterials International conference

    Zinchenko A. A

    International Symposium on EcoTopia Science 2011  2011.12.9 

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    Language：English   Presentation type：Oral presentation (invited, special)  

  33. Preparation of complex gel from DNA and chitosan and its application as metal ion adsorption material International conference

    Morikawa K, Zinchenko A

    The 100th CSJ Annual Meeting  2020.3.22 

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    Language：English   Presentation type：Poster presentation  

  34. Unimolecular compaction of megabase-long chromatin

    Zinchenko A

    Workshop on Polyelectrolytes in Chemistry, Biology and Technology 2018  2018.3.12 

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    Language：English   Presentation type：Oral presentation (general)  

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KAKENHI (Grants-in-Aid for Scientific Research) 7

  1. Preparation and characterization of carbon nanomaterials prepared by thermal treatment of biomass DNA

    Grant number：21K12306  2021.4 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

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    Authorship：Principal investigator 

    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

  2. DNA conformational behavior and functions in microcapsules

    Grant number：17K05611  2017.4 - 2020.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Zinchenko Anatoly

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    Authorship：Principal investigator  Grant type：Competitive

    In eukaryotic cells, DNA macromolecules with a length exceeding 1 meter are densely folded and exist in cells with a size of several μm. Artificial experimental models are needed to explain the higher order structure and behavior of DNA in cellular-like environment. In this study, we constructed an "artificial cell model" method for encapsulating very ling genomic DNA in polymer capsules of several μm size. Using this experimental model, we made clear the behavior of DNA confined in the cell-sized space. The experimental methodology proposed in this study is promising for gene delivery and related biomedical applications.

  3. Construction of 2- and 3-dimensional nanostructures using DNA metallization

    Grant number：24710106  2012.4 - 2015.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    ZINCHENKO Anatoly

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

    DNA extracted from salmon milt, the waste product of marine industry, was utilized as a functional material for construction of 2- and 3-dimensional nanomaterials for catalytic applications. DNA-based thin polymeric films and DNA hydrogels were first prepared and then used for efficient adsorption of noble metals (Au, Ag, Pt, Pg, etc.). After adsorption of metal ions inside DNA-based material, reduction of metal ions inside thin film/hydrogel resulted in a formation of well dispersed metal nanoparticles of several nanometer sizes with a narrow size distributions. Thus prepared hybrid materials showed high catalytic activity that can be controlled by swelling/shrinking of hydrogel matrix. In contrast to colloidal solutions of catalytic nanoparticles which separation and recovery problems limit their applications, DNA-based catalysts developed in this project are advantageous due to high stability, facile operation during catalysis, easy separation form reaction mixtures and reuse.

  4. ゲノムDNAのナノテンプレートによる構造と機能の制御

    Grant number：20034025  2008 - 2010

    ZINCHENKO A.A.

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\2900000 （ Direct Cost: \2900000 ）

    本研究では、様々なナノテンプレート(ナノメーターサイズ物質)を用いて、DNAとの相互作用および形成されるコンプレックスの形態をプログラミングすることに、DNA高次構造と機能の制御を目的としたものである。本年度、球状テンプレート(シリカナノ粒子)および棒状テンプレート(金ナノロッド)はDNA二次構造と高次構造に与える影響について研究した。(1) DNAの溶液中安定性およびDNA二次構造(二重らせん)の安定性に対するナノ粒子の影響を調べた。アニオン性ナノ粒子の影響はなかったが、カチオン性ナノ粒子はDNAの溶液中安定性を乱し、DNAの沈殿を起こし、更に、DNAを沈殿させないナノ粒子の濃度においても、DNAの二重らせんが高くなると連れて、DNA二重らせんの溶解は大きく抑制された。この結果から、自然界で起こるDNAの二重らせん溶解が必要な過程(転写、複製)では、カチオン性ナノ粒子がこのような過程を妨げると考えられる。(2) 次は、DNAとナノ粒子の間の相互作用における生物学的に重要な一価と二価カチオンの影響について研究した。その結果は、全てのカチオンがナノ粒子によってDNA凝縮を促進し、Na^+とK^+またはMg^<2+>とCa^<2+>の間は大直径のカチオンの効果が高かった。(3) 最後に、DNAとカチオン性ナノロッドの間相互作用を徹底的に調べ、ナノロッド濃度によって様々なDNA-ナノロッド複合体のナノ構造を観察行った。カチオン性ナノロッドはDNA凝縮を誘起することにより、DNA鎖上のナノロッドが自己組織化する。DNA対ナノロッドの割合によって、DNA鋳型に沿うって並んでおり、ナノロードの高濃度においてはDNAが凝縮しながら、DNAとコンプレックスしたナノロッドが高秩序構造(結晶状の構造)に組織化することを明らかにした。

  5. 時空間秩序の自己組織と生命現象化

    2007.1 - 2011.3

    科学研究費補助金  国際共同研究事業（ICORP），科学技術振興機構

    吉川　研一

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    Authorship：Other 

  6. Long chain DNA folding by nanoparticles: Construction of Artificial Chromatin Model

    Grant number：18719001  2006 - 2008

    ZINCHENKO A.a.

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\3740000 （ Direct Cost: \3500000 、 Indirect Cost：\240000 ）

  7. キラル低分子による長鎖DNAの折り畳み

    Grant number：04F04154  2004 - 2005

    日本学術振興会  科学研究費助成事業 特別研究員奨励費  特別研究員奨励費

    吉川 研一; ジンチェンコ アナトーリ

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    生物はキラルなアミノ酸を骨格にもつようなたんぱく質を活用することにより、キラリティを持つDNA分子と相互作用し、DNA分子の活性を制御していると考えられている。従来、DNAのキラリティの認識は、特異的な三次元構造を持つ高分子でなければ不可能であるとされてきたが、申請者らの研究により、3個程度の塩基性アミノ酸のオリゴマーを用いるだけでも、DNAの折り畳み構造についてほぼ100%のキラリティの認識を示すことを明らかにしてきた。このような成果をさらに発展させ、キラリティを認識するためには、何が必要となってくるのかについて、オリゴマーにかわる新たなキラリティをもつ物質を合成し、実験を積み重ねた。また、それの実験結果が、遺伝子発現についてどのように影響しているのかについて、化学的な立場からの考察を進めた。
    また、真核細胞の中では、DNAはヒストンと結合しクロマチンと呼ばれる複合体を形成して存在している。DNAは二重らせん構造をとることが良く知られているが、ヒストンと複合体を形成する際に、DNAのねじれが重要な役割を果たしていることが示唆されている。そこで、正電荷を帯びたナノ粒子をヒストンに見立てて、DNAとナノ粒子との複合体の形成に関して実験を行った。その結果、ナノ粒子を加えることによって、DNAはより凝縮しやすくなることを明らかにした。また、ヒストンと同じオーダーのナノ粒子を用いた時にもっともDNAが凝縮しやすくなることも明らかにした。この結果はクロマチン形成のメカニズムを議論する際に重要な役割を果たすことが期待される。

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To the head of KAKENHI (Grants-in-Aid for Scientific Research).▲

Industrial property rights 1

  1. 粒子材料及びその製造方法

    村田静昭, ジンチェンコ　アナトーリ, 蒲生彦

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    Application no：特願 2010-234833  Date applied：2010.10

    Country of applicant：Domestic  

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Teaching Experience (On-campus) 16

  1. Sustainability and Environmental Studies

    2020

  2. Fundamentals of Chemistry I

    2022

  3. Sustainable Materials Science (Formerly: Nanotechnology and Environment)

    2022

  4. Sustainability and Environmental Studies

    2022

  5. 環境物質学実験 2

    2018

  6. 環境物質学5

    2018

  7. 化学基礎Ｉ

    2018

  8. ナノテクノロジーと環境

    2018

  9. 環境物質学実験 2

    2017

  10. 環境物質学5

    2017

  11. ナノテクノロジーと環境

    2017

  12. 化学基礎Ｉ

    2017

  13. Laboratory in Chemistry

    2011

  14. 環境ナノテクノロジー

    2009

  15. 化学実験

    2009

  16. 環境物質5

    2009

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To the head of Teaching Experience (On-campus).▲
 

Media Coverage 1

  1. 化学グランプリ（作題・実行）

    日本化学会  2014.9

To the head of Media Coverage.▲