Updated on 2026/03/10
博士（医学） （ 2007.3 名古屋大学 ）
Endovascular aortic repair
Others / Other / General Surgery
Others / Other / Vascular and Endovascular Surgery
Nagoya University Graduate School, Division of Medical Sciences Vascular Surgery
2002.4 - 2006.3
Country： Japan
Nagoya University Faculty of Medicine
1990.4 - 1996.3
Country： Japan
Japanese Society of Surgery
Japanese Society of Phlebology
Japanese College of Angiology
Japanese Society of Cardiovascular Surgery
Japanese Society of Vascular Surgery
Tet2-driven clonal hematopoiesis drives aortic aneurysm via macrophage-to-osteoclast-like differentiation. Open Access
Yonekawa J, Yura Y, Luo J, Kato K, Ikeda S, Kawai Y, Hattori T, Okamoto R, Kizuki M, Miura-Yura E, Horitani K, Min KD, Emoto T, Banno H, Takefuji M, Walsh K, Murohara T
The Journal of clinical investigation 2026.2
Fujimura, N; Ichihashi, S; Shibata, T; Matsumura, H; Watanabe, M; Morikage, N; Kurimoto, Y; Banno, H; Uchiyama, H; Obara, H
JOURNAL OF ENDOVASCULAR THERAPY Vol. 33 ( 1 ) page： 227 - 235 2026.2
Ikeda, S; Sakurai, Y; Morimae, H; Kodama, A; Sawaki, S; Suda, H; Teramoto, C; Tanaka, K; Tokunaga, S; Tokuda, Y; Mutsuga, M; Banno, H
ANNALS OF VASCULAR SURGERY Vol. 122 page： 274 - 281 2026.1
Impact of Early Ambulation on Recovery Following Open Abdominal Aortic Aneurysm Repair
Nojiri, S; Akita, N; Kawai, Y; Takagi, D; Tanaka, S; Kobayashi, K; Sato, T; Ikeda, S; Sugimoto, M; Niimi, K; Banno, H
ANNALS OF VASCULAR SURGERY Vol. 121 page： 325 - 332 2025.12
Outcomes of Endovascular Repair for Infected Native Thoracic Aortic Aneurysms: A Japanese Multicentre Study. Open Access
Banno H, Kumamaru H, Akita N, Ikeda S, Lee C, Hoshina K, Nishimaki H, Shimizu H, Japanese Committee for Stentgraft Management (JACSM)
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2025.11
Sugimoto, M; Horiguchi, R; Ikeda, S; Kawai, Y; Niimi, K; Hyodo, R; Banno, H
VASCULAR Vol. 33 ( 5 ) page： 1049 - 1057 2025.10
Osawa, T; Akita, N; Lee, C; Ikeda, S; Sugimoto, M; Niimi, K; Banno, H
JOURNAL OF VASCULAR SURGERY Vol. 82 ( 2 ) page： 465 - 471.e1 2025.8
Ichihashi, S; Takahara, M; Fujimura, N; Banno, H; Onitsuka, S; Shingaki, M; Yamaoka, T; Sumi, M; Lida, O; Iwakoshi, S; Haulon, S; Kichikawa, K
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY Vol. 70 ( 2 ) page： 219 - 226 2025.8
Kawai, Y; Sugimoto, M; Osawa, T; Lee, CG; Ikeda, S; Niimi, K; Banno, H
VASCULAR page： 17085381251342332 2025.5
Sugimoto, M; Sato, T; Ikeda, S; Kawai, Y; Niimi, K; Banno, H
JOURNAL OF ENDOVASCULAR THERAPY Vol. 32 ( 2 ) page： 374 - 381 2025.4
Ichihashi, S; Takahara, M; Fujimura, N; Yamaoka, T; Banno, H; Shingaki, M; Shimamura, K; Kimura, F; Kurimoto, Y; Nakazawa, K; Yasuhara, K; Toya, N; Kobayashi, Y; Saito, Y; Shibata, T; Kaneko, K; Kotani, S; Tamura, Y; Onitsuka, S; Bolstad, F; Iwakoshi, S; Sakaguchi, S; Tanaka, T; Kichikawa, K
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY Vol. 48 ( 4 ) page： 438 - 446 2025.4
Sugimoto, M; Osawa, T; Lee, C; Ikeda, S; Kawai, Y; Niimi, K; Banno, H
ANNALS OF VASCULAR SURGERY Vol. 110 ( Pt B ) page： 10 - 16 2025.1
Kawai, Y; Sugimoto, M; Osawa, T; Lee, C; Ikeda, S; Niimi, K; Banno, H
ANNALS OF VASCULAR DISEASES Vol. 18 ( 1 ) 2025
Sugimoto, M; Lee, CG; Ikeda, S; Kawai, Y; Niimi, K; Banno, H
JOURNAL OF ENDOVASCULAR THERAPY page： 15266028241306277 2024.12
Sato, T; Banno, H; Ikeda, S; Kawai, Y; Tsuruoka, T; Sugimoto, M; Niimi, K; Kodama, A; Komori, K
JOURNAL OF ENDOVASCULAR THERAPY Vol. 31 ( 4 ) page： 706 - 712 2024.8
Kawai, Y; Fujimura, N; Obara, H; Ichihashi, S; Kudo, T; Hozawa, K; Yamaoka, T; Kato, T; Kawarada, O; Banno, H
ANNALS OF VASCULAR SURGERY Vol. 104 page： 174 - 184 2024.7
Kodama, A; Takahara, M; Koyama, A; Tokuda, T; Horiguchi, M; Sato, K; Kobayashi, T; Banno, H
JOURNAL OF VASCULAR SURGERY Vol. 79 ( 4 ) page： 42S - 43S 2024.4
Kawai, Y; Kodama, A; Sato, T; Ikeda, S; Tsuruoka, T; Sugimoto, M; Niimi, K; Banno, H; Komori, K
VASCULAR Vol. 32 ( 1 ) page： 65 - 75 2024.2
Ogawa, Y; Fujimura, N; Yamaguchi, M; Banno, H; Furuyama, T; Yamaoka, T; Sumi, M; Fukuda, T; Morikage, N; Sohgawa, E; Onitsuka, S; Nishimaki, H; Ichihashi, S
JOURNAL OF ENDOVASCULAR THERAPY Vol. 31 ( 1 ) page： 55 - 61 2024.2
Thoracic endovascular aortic repair and spinal cord injury
Banno, H; Lee, C; Ikeda, S; Kawai, Y; Sugimoto, M; Niimi, K
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 86 ( 1 ) page： 16 - 23 2024.2
Niimi, K; Nishida, K; Lee, C; Ikeda, S; Kawai, Y; Sugimoto, M; Banno, H
ANNALS OF VASCULAR SURGERY Vol. 98 page： 293 - 300 2024.1
Spinal Cord Infarction after Endovascular Aortic Repair for Infrarenal Abdominal Aortic Aneurysm Open Access
Konishi, Y; Yano, D; Banno, H; Kuwabara, F
ANNALS OF VASCULAR DISEASES Vol. 17 ( 3 ) page： 317 - 320 2024
Fujimura, N; Takahara, M; Obara, H; Ichihashi, S; George, RK; Igari, K; Banno, H; Hozawa, K; Yamaoka, T; Kian, CJ; Tan, JWH; Park, K; Skyi, PYC; Kato, T; Kawarada, O
JOURNAL OF ENDOVASCULAR THERAPY Vol. 30 ( 6 ) page： 828 - 837 2023.12
Sunagawa, M; Yokoyama, Y; Banno, H; Sugimoto, M; Mizuno, T; Yamaguchi, J; Onoe, S; Watanabe, N; Kawakatsu, S; Ebata, T
SURGERY TODAY Vol. 53 ( 11 ) page： 1320 - 1324 2023.11
Tokuda, Y; Terazawa, S; Yoshizumi, T; Ito, H; Banno, H; Mutsuga, M
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY Vol. 66 ( 2 ) page： 284 - 285 2023.8
Sugimoto, M; Banno, H; Sato, T; Ikeda, S; Tsuruoka, T; Kawai, Y; Niimi, K; Kodama, A; Komori, K
JOURNAL OF ENDOVASCULAR THERAPY Vol. 30 ( 4 ) page： 525 - 533 2023.8
Horiguchi, R; Takehara, Y; Sugiyama, M; Hyodo, R; Komada, T; Matsushima, M; Naganawa, S; Mizuno, T; Sakurai, Y; Sugimoto, M; Banno, H; Komori, K; Itatani, K
JOURNAL OF MAGNETIC RESONANCE IMAGING Vol. 57 ( 4 ) page： 1199 - 1211 2023.4
Ikeda, S; Sato, T; Kawai, Y; Tsuruoka, T; Sugimoto, M; Niimi, K; Banno, H
JOURNAL OF VASCULAR SURGERY Vol. 77 ( 1 ) page： 136 - + 2023.1
Epicardial adipose tissue volume is associated with abdominal aortic aneurysm expansion Open Access
Kawai, Y; Banno, H; Sato, T; Ikeda, S; Tsuruoka, T; Sugimoto, M; Niimi, K; Kodama, A; Matsui, K; Matsui, S; Komori, K
JOURNAL OF VASCULAR SURGERY Vol. 76 ( 5 ) page： 1253 - 1260 2022.11
Kodama, A; Komori, K; Koyama, A; Sato, T; Ikeda, S; Tsuruoka, T; Kawai, Y; Niimi, K; Sugimoto, M; Banno, H; Nishida, K
CIRCULATION JOURNAL Vol. 86 ( 6 ) page： 995 - + 2022.6
Impella5.0 "ILIPELLA" Approach for a Fulminant Myocarditis Patient With a Small Peripheral Artery
Mutsuga, M; Banno, H; Okumura, T; Morimoto, R; Kondo, T; Kimura, Y; Hiraiwa, H; Murohara, T; Usui, A
HEART LUNG AND CIRCULATION Vol. 31 ( 5 ) page： E72 - E74 2022.5
New Morphological Factor for Predicting Late Proximal Type I Endoleak after Endovascular Aneurysm Repair Open Access
Banno, H; Sugimoto, M; Sato, T; Ikeda, S; Kawai, Y; Tsuruoka, T; Kodama, A; Komori, K
ANNALS OF VASCULAR SURGERY Vol. 81 page： 154 - 162 2022.4
Ikeda, S; Kodama, A; Kawai, Y; Tsuruoka, T; Sugimoto, M; Niimi, K; Banno, H; Komori, K
SURGERY TODAY Vol. 52 ( 1 ) page： 98 - 105 2022.1
Endovascular Aneurysm Repair Compared With Open Repair Does Not Improve Survival in Octogenarians Open Access
Banno, H; Sugimoto, M; Sato, T; Ikeda, S; Kawai, Y; Tsuruoka, T; Kodama, A; Komori, K
CIRCULATION JOURNAL Vol. 85 ( 12 ) page： 2166 - + 2021.12
Acute esophageal necrosis after endovascular abdominal aneurysm repair Open Access
Sato, T; Banno, H; Komori, K
JOURNAL OF VASCULAR SURGERY CASES INNOVATIONS AND TECHNIQUES Vol. 7 ( 4 ) page： 597 - 598 2021.12
Sugimoto, M; Banno, H; Sato, T; Ikeda, S; Tsuruoka, T; Kawai, Y; Niimi, K; Kodama, A; Komori, K
ANNALS OF VASCULAR SURGERY Vol. 75 page： 420 - 429 2021.8
Time-to-Event Analysis of the Impact of Endovascular Aortic Aneurysm Repair on Chronic Renal Decline
Sugimoto, M; Banno, H; Sato, T; Ikeda, S; Tsuruoka, T; Kawai, Y; Niimi, K; Kodama, A; Komori, K
ANNALS OF VASCULAR SURGERY Vol. 74 page： 165 - 175 2021.7
Midterm Outcomes of Zone 0 Antegrade Endograft Implantation During Type I Hybrid Aortic Arch Repair Open Access
Banno, H; Mutsuga, M; Sugimoto, M; Tokuda, Y; Kodama, A; Usui, A; Komori, K
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY Vol. 61 ( 6 ) page： 938 - 944 2021.6
Low-density vulnerable thrombus/plaque volume on preoperative computed tomography predicts for spinal cord ischemia after endovascular repair for thoracic aortic aneurysm.
Banno H, Kawai Y, Sato T, Tsuruoka T, Sugimoto M, Kodama A, Komori K
Journal of vascular surgery Vol. 73 ( 5 ) page： 1557 - 1565.e1 2021.5
Beating-heart total arch replacement for an octogenarian patient with severe heart failure Open Access
Mutsuga, M; Banno, H; Tokuda, Y; Usui, A
JOURNAL OF CARDIAC SURGERY Vol. 36 ( 3 ) page： 1126 - 1129 2021.3
Meshii, K; Sugimoto, M; Niimi, K; Kodama, A; Banno, H; Komori, K
JOURNAL OF VASCULAR SURGERY Vol. 73 ( 1 ) page： 99 - 107 2021.1
Early and midterm outcomes of celiac artery coverage during thoracic endovascular aortic repair Open Access
Banno, H; Ikeda, S; Kawai, Y; Meshii, K; Takahashi, N; Sugimoto, M; Kodama, A; Komori, K
JOURNAL OF VASCULAR SURGERY Vol. 72 ( 5 ) page： 1552 - 1557 2020.11
Mutsuga, M; Banno, H; Narita, Y; Komori, K; Usui, A
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 82 ( 4 ) page： 657 - 666 2020.11
Sugimoto, M; Ikeda, S; Kawai, Y; Tsuruoka, T; Niimi, K; Kodama, A; Banno, H; Komori, K
JOURNAL OF VASCULAR SURGERY Vol. 72 ( 1 ) page： E188 - E189 2020.7
Fujii, T; Banno, H; Kodama, A; Sugimoto, M; Akita, N; Tsuruoka, T; Sakakibara, M; Komori, K
ANNALS OF VASCULAR SURGERY Vol. 66 page： 85 - + 2020.7
Ikeda, S; Kodama, A; Komori, K; Banno, H; Sugimoto, M; Niimi, K; Kawai, Y; Tsuruoka, T
JOURNAL OF VASCULAR SURGERY Vol. 72 ( 1 ) page： E88 - E88 2020.7
Zinc Deficiency and Clinical Outcome After Infrainguinal Bypass Grafting for Critical Limb Ischemia. Open Access
Koyama A, Kodama A, Tsuruoka T, Fujii T, Sugimoto M, Banno H, Komori K
Circulation reports Vol. 2 ( 3 ) page： 167 - 173 2020.2
Banno, H; Ikeda, S; Kawai, Y; Fujii, T; Akita, N; Takahashi, N; Sugimoto, M; Kodama, A; Komori, K
JOURNAL OF VASCULAR SURGERY Vol. 71 ( 2 ) page： 450 - 456 2020.2
Associations of nutritional status and muscle size with mortality after open aortic aneurysm repair Open Access
Kodama, A; Takahashi, N; Sugimoto, M; Niimi, K; Banno, H; Komori, K
JOURNAL OF VASCULAR SURGERY Vol. 70 ( 5 ) page： 1585 - 1593 2019.11
Sugimoto, M; Takahashi, N; Niimi, K; Kodama, A; Banno, H; Komori, K
CIRCULATION JOURNAL Vol. 83 ( 9 ) page： 1844 - 1850 2019.9
Banno H, Akita N, Fujii T, Tsuruoka T, Takahashi N, Sugimoto M, Niimi K, Komori K
Annals of vascular surgery Vol. 56 page： 108 - 113 2019.4
Three cases of dorsal metatarsal artery bypass in patients with Buerger disease
Kodama Akio, Takahashi Noriko, Sugimoto Masayuki, Niimi Kiyoaki, Banno Hiroshi, Komori Kimihiro
JOURNAL OF VASCULAR SURGERY CASES AND INNOVATIVE TECHNIQUES Vol. 4 ( 3 ) page： 185 - 188 2018.9
Sugimoto Masayuki, Takahashi Noriko, Niimi Kiyoaki, Kodama Akio, Banno Hiroshi, Komori Kimihiro
ANNALS OF VASCULAR SURGERY Vol. 50 page： 179 - 185 2018.7
Aneurysm Sac Thrombus Volume Predicts Endoleak With Aneurysm Expansion After Endovascular Aneurysm Repair Open Access
Fujii, T; Banno, H; Takahashi, N; Sugimoto, M; Niimi, K; Komori, K
JOURNAL OF VASCULAR SURGERY Vol. 67 ( 6 ) page： E80 - E80 2018.6
Long-term fate of renal function after open surgery for juxtarenal and pararenal aortic aneurysm Open Access
Sugimoto Masayuki, Takahashi Noriko, Niimi Kiyoaki, Kodama Akio, Banno Hiroshi, Komori Kimihiro
JOURNAL OF VASCULAR SURGERY Vol. 67 ( 4 ) page： 1042 - 1050 2018.4
Kodama Akio, Koyama Akio, Sugimoto Masayuki, Niimi Kiyoaki, Banno Hiroshi, Komori Kimihiro
CIRCULATION JOURNAL Vol. 82 ( 1 ) page： 267 - 274 2018.1
Sugimoto Masayuki, Koyama Akio, Niimi Kiyoaki, Kodama Akio, Banno Hiroshi, Komori Kimihiro
ANNALS OF VASCULAR SURGERY Vol. 43 page： 96 - 103 2017.8
Maekawa Takashi, Komori Kimihiro, Kodama Akio, Banno Hiroshi, Narita Hiroshi, Sugimoto Masayuki
SURGERY TODAY Vol. 47 ( 3 ) page： 293 - 300 2017.3
Tokunaga Seisaku, Ihara Tsutomu, Banno Hiroshi, Kodama Akio, Sugimoto Masayuki, Komori Kimihiro
ANNALS OF VASCULAR SURGERY Vol. 39 page： 119 - 127 2017.2
Relationship between the distal migration and length of the distal landing zone after endovascular aneurysm repair (EVAR). Reviewed
Ihara T, Komori K, Banno H, Kodama A, Yamamoto K, Sugimoto M
Surgery Today Vol. 46 ( 1 ) page： 56-61 2016.1
Who should do endovascular repair of complex aortic aneurysms and how should they do them? Invited Reviewed
Banno H, Marzelle J, Becquemin JP.
Surgeon Vol. 13 ( 5 ) page： 286-291 2015.10
Pre- and Intraoperative Predictors of Delirium after Open Abdominal Aortic Aneurysm Repair.
Sugimoto M, Kodama A, Narita H, Banno H, Yamamoto K, Komori K
Annals of Vascular Disease Vol. 8 ( 3 ) page： 215-9 2015.7
The fate of ischemic limbs in patients with Buerger's disease based on our 30-year experience: does smoking have a definitive impact on the late loss of limbs? Reviewed
Sugimoto M, Miyachi H, Morimae H, Kodama A, Narita H, Banno H, Yamamoto K, Komori K.
Surgery Today Vol. 45 ( 4 ) page： 466-470 2015.4
Real chimney technique for total debranching of supra-aortic trunks. Reviewed
Kato M, Kagaya H, Kubo Y, Banno H, Ohkubo N.
Journal of Vascular Surgery Vol. 61 ( 2 ) page： 542-5 2015.2
Possible involvement of Notch signaling in the pathogenesis of Buerger's disease. Reviewed
Tamai H, Kobayashi M, Takeshita K, Kodama A, Banno H, Narita H, Yamamoto K, Komori K.
Surgery Today Vol. 44 ( 1 ) page： 307-13 2014
Inter-observer variability in sizing fenestrated and/or branched aortic stent-grafts. Reviewed
Banno H, Kobeiter H, Brossier J, Marzelle J, Presles E, Becquemin JP
European journal of Vascular and Endovascular Surgery Vol. 47 ( 1 ) page： 45-52 2014
Comparison of fenestrated endovascular aneurysm repair and chimney graft techniques for pararenal aortic aneurysm. Reviewed
Banno H, Cochennec F, Marzelle J, Becquemin JP.
Journal of Vascular Surgery Vol. 60 ( 1 ) page： 31-9 2014
Post-stress perfusion abnormalities detected on myocardial perfusion single-photon emission computed tomography predict long-term mortality after elective abdominal aortic aneurysm repair. Reviewed Open Access
Inoue Y, Yoshikawa D, Ishii H, Isobe S, Kumagai S, Suzuki S, Okumura S, Hayashi M, Matsubara T, Ohshima S, Banno H, Komori K, Kato K, Murohara T.
Circulation Journal Vol. 77 ( 5 ) page： 1229-34 2013
Three-dimensional workstation is useful for measuring the correct size of abdominal aortic aneurysm diameters. Reviewed
Ihara T, Komori K, Yamamoto K, Kobayashi M, Banno H, Kodama A.
Annals of Vascular Surgery Vol. 27 ( 2 ) page： 154-61 2013
Acute Lower Extremity Ischemia due to the Popliteal Pseudoaneurysm in a 16-year-old Boy with Multiple Exostoses. Reviewed
Banno H, Houbballah R, Becquemin JP.
Annals of Vascular Disease Vol. 6 ( 2 ) page： 215-217 2013
Cost disparity between open repair and endovascular aneurysm repair for abdominal aortic aneurysm: a single-institute experience in Japan. Reviewed
Morimae H, Maekawa T, Tamai H, Takahashi N, Ihara T, Hori A, Narita H, Banno H, Kobayashi M, Yamamoto K, Komori K.
Surgery Today Vol. 42 ( 2 ) page： 121-6 2012
Surgical experience of 13 infected infrarenal aortoiliac aneurysms: preoperative control of septic condition determines early outcome. Reviewed
Sugimoto M, Banno H, Idetsu A, Matsushita M, Ikezawa T, Komori K.
Surgery Vol. 149 ( 5 ) page： 699-704 2011.5
Relationship between the diameter of the vein graft and postoperative ankle brachial pressure index following femoro-popliteal bypass. Reviewed
Matsushita M, Ikezawa T, Banno H.
Int Angiol Vol. 27 ( 4 ) page： 329-332 2008.8
Pitavastatin inhibits intimal hyperplasia in rabbit vein graft. Reviewed
Fujita H, Banno H, Yamanouchi D, Kobayashi M, Yamamoto K, Komori K.
J Surg Res Vol. 148 ( 2 ) page： 238-43 2007.10
Controlled release of small interfering RNA targeting midkine attenuates intimal hyperplasia in vein grafts.
Banno H, Takei Y, Muramatsu T, Komori K, Kadomatsu K.
Journal of Vascular Surgery Vol. 46 ( 1 ) page： 116-23 2007.7
Celiprolol reduces the intimal thickening of autogenous vein grafts via an enhancement of nitric oxide function through an inhibition of superoxide production. Reviewed
Hattori K, Yamanouchi D, Banno H, Kobayashi M, Yamamoto K, Kajikuri J, Itoh T,Komori K.
Journal of Vascular Surgery Vol. 46 ( 1 ) page： 113-23 2007.7
Hydrophilic statin suppresses vein graft intimal hyperplasia via endothelial cell-tropic Rho-kinase inhibition. Reviewed
Yamanouchi D, Banno H, Nakayama M, Sugimoto M, Fujita H, Kobayashi M, KuwanoH, Komori K.
Journal of Vascular Surgery Vol. 42 ( 4 ) page： 757-64 2005.10
Antisense oligodeoxyribonucleotide as to the growth factor midkine suppresses neointima formation induced by balloon injury. Reviewed
Hayashi K, Banno H, Kadomatsu K, Takei Y, Komori K, Muramatsu T.
Am J Physiol Heart Circ Physiol Vol. 288 ( 5 ) page： 2203-9 2005.1
External iliac venous aneurysm in a pregnant woman: a casereport. Reviewed
Banno H, Yamanouchi D, Fujita H, Nagata J, Kobayashi M, Matsushita M, Nishikimi N, Komori K.
Journal of Vascular Surgery Vol. 40 ( 1 ) page： 174-8 2004.7
血行再建術のガイドラインを識る
坂野比呂志, 古森公浩（ Role： Sole author）
Heart View 2011.4
【大動脈瘤診療のめざましい進歩】 手術かステントグラフトか
坂野比呂志, 古森公浩（ Role： Sole author）
臨牀と研究 2010.11
大動脈瘤疾患と血液凝固線溶との関連
坂野比呂志, 古森公浩（ Role： Sole author）
日本血栓止血学会誌 2006.2
Grant number：24K11970 2024.4 - 2027.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Authorship：Coinvestigator(s)
Grant number：22K08917 2022.4 - 2025.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Sugimoto Masayuki
Authorship：Coinvestigator(s)
This research focused on the diagnosis and management of type 2 endoleaks following endovascular aortic aneurysm repair (EVAR). Using 4D-flow MRI technology, we analyzed blood flow dynamics that conventional contrast CT imaging cannot capture.
Our findings revealed factors associated with early and late spontaneous sac shrinkage, the relationship between perioperative hypogastric artery embolization and type 2 endoleaks, correlation between D-dimer levels and sac diameter changes, effects of stent grafts on renal arterial flow dynamics, increased local energy loss after EVAR, and the impact of significant sac shrinkage on endograft tortuosity at 5 years post-EVAR. These insights enable better prediction and differentiation between cases requiring reintervention and those suitable for observation alone, allowing for treatment optimization and contributing to improved long-term outcomes of EVAR procedures.
Grant number：21K08840 2021.4 - 2025.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Banno Hiroshi
Authorship：Principal investigator
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
The study included 130 cases of thoracic endovascular aortic repair (TEVAR) for spinal cord injury (SCI) and 130 control cases at 55 facilities that had given consent to participate in the study between January 2016 and December 2019. We are currently modifying the NCD system and collecting image data for additional data entry. Meanwhile, in a study conducted on cases from neighboring facilities, preoperative dialysis, the volume of thrombus in the descending thoracic aorta, the low-density thrombus volume, and the median density of the thrombus were found to be significant risk factors, and in a multivariate analysis, the low-density thrombus volume was the only risk factor (odds ratio 7.22, 95% confidence interval [2.16-24.11]).
Grant number：21K08839 2021.4 - 2025.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Kawai Yohei
Authorship：Coinvestigator(s)
Background: Leukotriene-lipoxygenase pathway metabolites have been reported to induce inflammatory responses and promote the progression of atherosclerosis. The aim of this study was to investigate the anti-inflammatory effects of a drug that inhibits the leukotriene-lipoxygenase pathway in relation to vascular disease and to propose a novel therapeutic strategy for aneurysms.Methods: An aortic aneurysm model was established by continuous subcutaneous infusion of angiotensin II in apolipoprotein E-deficient (ApoE－/－) mice. The azelastine group received daily administration of azelastine, while the PBS group received phosphate-buffered saline (PBS), both for 28 consecutive days starting from the day of osmotic pump implantation. Aneurysm diameter was measured weekly using ultrasound, and direct measurements were taken after euthanasia on day 28. Results: In the murine aneurysm model, azelastine did not show a significant inhibitory effect on aneurysm enlargement.
Analysis of a Hemodynamic Modification Model for Rupture Suppression
Grant number：21K08841 2021.4 - 2025.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Niimi Kiyoaki
Authorship：Coinvestigator(s)
The ultimate tensile strength (UTS) of wet normal porcine aortas (PTA) was higher than that of human aneurysmal arteries (HA), while the porosity from dried samples was significantly greater in HA. However, no significant correlation was found between UTS and porosity. To assess their relationship using the same sample, we developed a method enabling tensile testing while visualizing aortic internal structures. Assuming rupture occurs at the boundaries of calcifications or voids, we tested contrast-enhance imaging and found Iomeron effective for structural visualization. The contrast agent caused no noticeable degradation, and allowed imaging of calcification, voids, soft tissue, and adventitial vasa vasorum in wet samples. A CT-compatible tensile testing device is under development, and we plan to examine whether rupture occurs at these structural boundaries.
亜鉛をターゲットとした閉塞性動脈硬化症に対する新しい治療戦略
Grant number：20K09123 2020.4 - 2022.3
科学研究費助成事業 基盤研究(C)
古森 公浩, 坂野 比呂志, 児玉 章朗, 新美 清章, 杉本 昌之
Authorship：Coinvestigator(s)
亜鉛は生命体における必須ミネラルで、近年亜鉛欠乏と動脈硬化との関連が報告されている。また我々は重症下肢虚血における下肢バイパス術の臨床的検討において亜鉛欠乏群では、正常群に比べバイパス開存率・救肢率・Amputation free survaival・創傷治癒率は不良であることを世界で初めて報告した。亜鉛欠乏と血管内膜肥厚および下肢虚血作成後の血管新生反応に及ぼす影響についての検討は、これまでになされていない。本研究の目的は、亜鉛欠乏モデルに関して検討し閉塞性動脈硬化症(ASO)に対する新規治療戦略を提唱することにある。
【目的】 亜鉛欠乏は、創傷治癒遅延、心血管障害など、様々な障害を引き起こすことが知られている。我々は重症虚血肢患者の亜鉛欠乏群は亜鉛正常群に比べ救肢率、創傷治癒率、いずれも有意差をもって低値であることを既に報告している。今回、我々はその機序解明のため、マウスモデルを用いて亜鉛欠乏が血管新生能に与える影響を検討した。
【方法】 野生型マウスに亜鉛欠乏食を週令3週より投与し、亜鉛欠乏モデルを作成。亜鉛欠乏(ZD)群と対照(C)群について、週令10週で左大腿動脈を結紮し、虚血肢を作成。虚血後の血管新生能を、レーザードップラー法(LDBF)による虚血肢/健肢の血流を比較した。また、活性酸素種（ROS）の検出を目的としてジヒドロエチジウム（DHE）染色と血中D-ROM濃度を測定し、血清ニトロチロシンをELISAで定量化した。筋組織中のNADPH oxidase（Nox）のサブユニット（Nox2、p22phox、p47phox、p67phox）および血管内皮増殖因子（VEGF）をRT-PCRで解析した。
【結果】 ZD群では、筋線維中のDHEの発色が増強し、血中D-ROM濃度も有意に増加した。LDBFにて測定した虚血肢/健肢血流比が、C群と比較し、術後14日目以降有意に低下 していた。毛細血管密度もZD群が有意に低かった。また、ZD群は虚血組織の筋線維におけるジヒドロエチジウム（DHE）の発現は増加し、血中D-ROM濃度、血清ニトロチロシン濃度のいずれも有意に上昇した。虚血肢内転筋のRT-PCRの解析の結果、NoxのサブユニットはいずれもZD群で有意に増加し、VEGFの発現は低下した。
Exploratory research of novel management targeting Xa inhibitor for vascular diseases
Grant number：18K08728 2018.4 - 2021.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
BANNO Hiroshi
Authorship：Principal investigator
Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）
Aneurysm model: Xa inhibitor was administered to mouse ascites-derived macrophages and gene expression analysis was performed. Apixaban administration suppressed MCP-1 expression, and edoxaban administration significantly increased TNF-α, IL-1b, IL-6, cathepsin K, and S gene expression. Therefore, apixaban and edoxaban were administered to the mouse aneurysm model, but the aneurysm-suppressing effect was not confirmed. On the contrary, anal bleeding was observed at all concentrations as a possible side effect.
Intimal hyperplasia model: A bypass model using the external jugular vein as a graft was created using rabbits. The intimal hyperplasia was evaluated by classifying into the edoxaban-administered group and the non-administered group, but no significant difference was observed between the two groups.
Potent Inhibiting Effect of Activated vitamine D3 on Aortic Aneurysm Dilatation
Grant number：17K10753 2017.4 - 2020.3
NIIMI Kiyoaki
Authorship：Coinvestigator(s)
The activity of endogenous MCP-1 was significantly lower in the calsitriol group than in the Saline group. However, there was no significant difference in expression level of IL-1βand MMP-9 causing degeneration of the extracellular matrix between the Saline and calsitriol groups. In that series, we decided to evaluate another anti-inflammatory subject that can suppress atherosclerotic disease. Montelukast is a selective CVS-LT-1receptor antagonist that could surpress atherosclerotic diseases. We evaluated the in vitro properties of montelukast and its in vivo activities in an angiotensinⅡ-infused apolipoprotein E-deficient AAA mouse model. Relative to control,montelukast significantly suppressed gene expression of MMP-2, MMP-9, and IL-1β.In vivo,montelukast significantly decreased aortic expansion and induced infiltration of M2 macrophages.
Functions of Nitric Oxide and Endothelium-derived Hyperpolarizing Factor are impaired in Poor Run-off Autogenous Rabbit Arterial Grafts
Grant number：17H04290 2017.4 - 2020.3
KOMORI Kimihiro
Authorship：Coinvestigator(s)
Background: Vascular endothelium induces smooth muscle cell (SMC) relaxation mainly mediated by endothelium-derived nitric oxide (EDNO) and endothelium-derived hyperpolarizing factor (EDHF). The present study was undertaken to determine whether the functions of EDNO and EDHF might be altered in poor run-off artery graft compared to “non-occluded graft”. Methods: The carotid artery was excised and implanted in its original position as an autogenous graft(“non-occluded graft”), and the most inferior branch of the external carotid artery served as the only outflow for the present conditions (“poor run-off graft”).
Conclusions: The functions of both EDNO and EDHF are impaired in poor run-off artery grafts.
3D Imaging Analysis to Elucidate Predictors for Long-term results after Endovascular Aortic Aneurysm Repair
Grant number：16K10657 2016.4 - 2019.3
SUGIMOTO Masayuki
Authorship：Coinvestigator(s)
In this observational clinical study, longitudinal anatomical measurement of abdominal aortic aneurysms after endovascular repair was performed using a dedicated 3D workstation (Aquarius; TeraRecon). Statistical analysis of those anatomical factors, in combination with clinical data, has revealed: 1) specific clinical backgrounds of our series in comparison with other large clinical studies, 2) several predictors for long-term outcomes such as aneurysmal shrinkage. Notably, our study has elucidated new insights about predictors for type II endoleak and resulting aneurysm enlargement.
Impact of Clopidogrel and Prasugrel on suppression of autogenous vein graft.
Grant number：15K10240 2015.4 - 2018.3
KODAMA Akio
Authorship：Coinvestigator(s)
We performed reversed vein graft under normal and poor run-off model. At first some of grafted veins were occluded because of technical problems, thereby, it was difficult to evaluate the effects of Clopidogrel and Prasugrel. Finally the technical problems were resolved. At the same time we tried to search the optimal administration methods and dosage of these drugs. However, we could not to find them. Therefore, we made some grafted veins of Edoxaban-treated rabbits. The assessment of intimal hyperplasia did not show significant differences in their lumen area, intimal thickness, medial thickness, and intima/media index between control grafted veins and Edoxaban-treated grafted veins.
血管内膜肥厚の成因とその制御-EDHFをターゲットとした新しい探索研究-
2013.4 - 2015.3
科学研究費補助金 基盤研究(B)
糖尿病治療薬をターゲットとした新しい血管病治療の探索研究
2012.4 - 2013.3
科学研究費補助金
Authorship：Coinvestigator(s)
ＣＴ画像解析によるステントグラフト形態の変化の分析
2010.4 - 2012.3
科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
ステント内膜肥厚抑制の新しいアプローチ −Ezetimibeの効果検証
2010.4 - 2012.3
科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
