Updated on 2022/08/01

写真a

 
BANNO, Hiroshi
 
Organization
Graduate School of Medicine Program in Integrated Medicine Musculoskeletal and Cutaneous Medicine Professor
Graduate School
Graduate School of Medicine
Title
Professor
Contact information
メールアドレス
External link

Degree 1

  1. 博士(医学) ( 2007.3   名古屋大学 ) 

Research Interests 1

  1. Endovascular aortic repair

Research Areas 2

  1. Others / Others  / General Surgery

  2. Others / Others  / Vascular and Endovascular Surgery

Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences   Vascular Surgery

    2002.4 - 2006.3

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    1990.4 - 1996.3

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    Country: Japan

Professional Memberships 5

  1. Japanese Society of Surgery

  2. Japanese Society of Phlebology

  3. Japanese College of Angiology

  4. Japanese Society of Cardiovascular Surgery

  5. Japanese Society of Vascular Surgery

 

Papers 51

  1. Impella5.0 "ILIPELLA" Approach for a Fulminant Myocarditis Patient With a Small Peripheral Artery.

    Mutsuga M, Banno H, Okumura T, Morimoto R, Kondo T, Kimura Y, Hiraiwa H, Murohara T, Usui A

    Heart, lung & circulation   Vol. 31 ( 5 ) page: e72 - e74   2022.5

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    Language:English  

    DOI: 10.1016/j.hlc.2021.12.007

    PubMed

  2. New Morphological Factor for Predicting Late Proximal Type I Endoleak after Endovascular Aneurysm Repair.

    Banno H, Sugimoto M, Sato T, Ikeda S, Kawai Y, Tsuruoka T, Kodama A, Komori K

    Annals of vascular surgery   Vol. 81   page: 154 - 162   2022.4

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    Language:English  

    DOI: 10.1016/j.avsg.2021.09.049

    PubMed

  3. Impact of Serum Zinc Level and Oral Zinc Supplementation on Clinical Outcomes in Patients Undergoing Infrainguinal Bypass for Chronic Limb-Threatening Ischemia.

    Kodama A, Komori K, Koyama A, Sato T, Ikeda S, Tsuruoka T, Kawai Y, Niimi K, Sugimoto M, Banno H, Nishida K

    Circulation journal : official journal of the Japanese Circulation Society     2022.3

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    Language:English  

    DOI: 10.1253/circj.CJ-21-0832

    PubMed

  4. Factors Associated With Spontaneous Sac Shrinkage in Patients With Persistent Type 2 Endoleaks After EVAR

    Sugimoto Masayuki, Banno Hiroshi, Sato Tomohiro, Ikeda Shuta, Tsuruoka Takuya, Kawai Yohei, Niimi Kiyoaki, Kodama Akio, Komori Kimihiro

    JOURNAL OF ENDOVASCULAR THERAPY     page: 15266028221083457   2022.3

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  5. Preoperative sarcopenia and malnutrition are correlated with poor long-term survival after endovascular abdominal aortic aneurysm repair

    Ikeda Shuta, Kodama Akio, Kawai Yohei, Tsuruoka Takuya, Sugimoto Masayuki, Niimi Kiyoaki, Banno Hiroshi, Komori Kimihiro

    SURGERY TODAY   Vol. 52 ( 1 ) page: 98 - 105   2022.1

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  6. Acute esophageal necrosis after endovascular abdominal aneurysm repair

    Sato Tomohiro, Banno Hiroshi, Komori Kimihiro

    JOURNAL OF VASCULAR SURGERY CASES INNOVATIONS AND TECHNIQUES   Vol. 7 ( 4 ) page: 597 - 598   2021.12

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  7. Endovascular Aneurysm Repair Compared With Open Repair Does Not Improve Survival in Octogenarians

    Banno Hiroshi, Sugimoto Masayuki, Sato Tomohiro, Ikeda Shuta, Kawai Yohei, Tsuruoka Takuya, Kodama Akio, Komori Kimihiro

    CIRCULATION JOURNAL   Vol. 85 ( 12 ) page: 2166 - +   2021.12

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  8. Time-to-Event Analysis of the Impact of Endovascular Aortic Aneurysm Repair on Chronic Renal Decline

    Sugimoto Masayuki, Banno Hiroshi, Sato Tomohiro, Ikeda Shuuta, Tsuruoka Takuya, Kawai Yohei, Niimi Kiyoaki, Kodama Akio, Komori Kimihiro

    ANNALS OF VASCULAR SURGERY   Vol. 74   page: 165 - 175   2021.7

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  9. Midterm Outcomes of Zone 0 Antegrade Endograft Implantation During Type I Hybrid Aortic Arch Repair

    Banno Hiroshi, Mutsuga Masato, Sugimoto Masayuki, Tokuda Yoshiyuki, Kodama Akio, Usui Akihiko, Komori Kimihiro

    EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY   Vol. 61 ( 6 ) page: 938 - 944   2021.6

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  10. Low-density vulnerable thrombus/plaque volume on preoperative computed tomography predicts for spinal cord ischemia after endovascular repair for thoracic aortic aneurysm.

    Banno H, Kawai Y, Sato T, Tsuruoka T, Sugimoto M, Kodama A, Komori K

    Journal of vascular surgery   Vol. 73 ( 5 ) page: 1557 - 1565.e1   2021.5

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    Language:English  

    DOI: 10.1016/j.jvs.2020.09.026

    PubMed

  11. Clinical comparison between early and late spontaneous sac shrinkage after endovascular aortic aneurysm repair.

    Sugimoto M, Banno H, Sato T, Ikeda S, Tsuruoka T, Kawai Y, Niimi K, Kodama A, Komori K

    Annals of vascular surgery     2021.4

  12. Beating-heart total arch replacement for an octogenarian patient with severe heart failure

    Mutsuga Masato, Banno Hiroshi, Tokuda Yoshiyuki, Usui Akihiko

    JOURNAL OF CARDIAC SURGERY   Vol. 36 ( 3 ) page: 1126 - 1129   2021.3

  13. The association between perioperative embolization of hypogastric arteries and type II endoleaks after endovascular aortic aneurysm repair

    Meshii Katsuaki, Sugimoto Masayuki, Niimi Kiyoaki, Kodama Akio, Banno Hiroshi, Komori Kimihiro

    JOURNAL OF VASCULAR SURGERY   Vol. 73 ( 1 ) page: 99 - 107   2021.1

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  14. Which is superior, the frozen elephant trunk technique alone or the classical elephant trunk technique followed by second-stage thoracic endovascular aortic repair for extensive aortic arch repair?

    Mutsuga Masato, Banno Hiroshi, Narita Yuji, Komori Kimihiro, Usui Akihiko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 4 ) page: 657 - 666   2020.11

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  15. Early and midterm outcomes of celiac artery coverage during thoracic endovascular aortic repair

    Banno Hiroshi, Ikeda Shuta, Kawai Yohei, Meshii Katsuaki, Takahashi Noriko, Sugimoto Masayuki, Kodama Akio, Komori Kimihiro

    JOURNAL OF VASCULAR SURGERY   Vol. 72 ( 5 ) page: 1552 - 1557   2020.11

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  16. Influence of Preoperative Sarcopenia and Nutritional Status on Midterm and Long-term Mortality of Abdominal Aortic Aneurysm After Endovascular Aneurysm Repair

    Ikeda Shuta, Kodama Akio, Komori Kimihiro, Banno Hiroshi, Sugimoto Masayuki, Niimi Kiyoaki, Kawai Yohei, Tsuruoka Takuya

    JOURNAL OF VASCULAR SURGERY   Vol. 72 ( 1 ) page: E88 - E88   2020.7

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    Language:Japanese  

    Web of Science

  17. Clinical Comparison Between Early and Late Spontaneous Sac Shrinkage After Endovascular Aortic Aneurysm Repair

    Sugimoto Masayuki, Ikeda Shuta, Kawai Yohei, Tsuruoka Takuya, Niimi Kiyoaki, Kodama Akio, Banno Hiroshi, Komori Kimihiro

    JOURNAL OF VASCULAR SURGERY   Vol. 72 ( 1 ) page: E188 - E189   2020.7

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    Language:Japanese  

    Web of Science

  18. Aneurysm Sac Thrombus Volume Predicts Aneurysm Expansion with Type II Endoleak After Endovascular Aneurysm Repair

    Fujii Takayuki, Banno Hiroshi, Kodama Akio, Sugimoto Masayuki, Akita Naohiro, Tsuruoka Takuya, Sakakibara Masashi, Komori Kimihiro

    ANNALS OF VASCULAR SURGERY   Vol. 66   page: 85 - +   2020.7

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  19. Zinc Deficiency and Clinical Outcome After Infrainguinal Bypass Grafting for Critical Limb Ischemia.

    Koyama A, Kodama A, Tsuruoka T, Fujii T, Sugimoto M, Banno H, Komori K

    Circulation reports   Vol. 2 ( 3 ) page: 167 - 173   2020.2

  20. Suprarenal fixation is associated with worse midterm renal function after endovascular abdominal aortic aneurysm repair compared with infrarenal fixation

    Banno Hiroshi, Ikeda Shuta, Kawai Yohei, Fujii Takayuki, Akita Naohiro, Takahashi Noriko, Sugimoto Masayuki, Kodama Akio, Komori Kimihiro

    JOURNAL OF VASCULAR SURGERY   Vol. 71 ( 2 ) page: 450 - 456   2020.2

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  21. Associations of nutritional status and muscle size with mortality after open aortic aneurysm repair

    Kodama Akio, Takahashi Noriko, Sugimoto Masayuki, Niimi Kiyoaki, Banno Hiroshi, Komori Kimihiro

    JOURNAL OF VASCULAR SURGERY   Vol. 70 ( 5 ) page: 1585 - 1593   2019.11

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  22. Effect of Intraoperative Division of the Left Renal Vein on the Fate of Renal Function and Left Renal Volume After Open Repair of Para- and Juxtarenal Aortic Aneurysm

    Sugimoto Masayuki, Takahashi Noriko, Niimi Kiyoaki, Kodama Akio, Banno Hiroshi, Komori Kimihiro

    CIRCULATION JOURNAL   Vol. 83 ( 9 ) page: 1844 - 1850   2019.9

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  23. Proximal Bare Stent May Reduce Bird-Beak Configuration, Which is Associated with Distal Migration of Stent Graft in the Aortic Arch.

    Banno H, Akita N, Fujii T, Tsuruoka T, Takahashi N, Sugimoto M, Niimi K, Komori K

    Annals of vascular surgery   Vol. 56   page: 108 - 113   2019.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.avsg.2018.08.081

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  24. Three cases of dorsal metatarsal artery bypass in patients with Buerger disease

    Kodama Akio, Takahashi Noriko, Sugimoto Masayuki, Niimi Kiyoaki, Banno Hiroshi, Komori Kimihiro

    JOURNAL OF VASCULAR SURGERY CASES AND INNOVATIVE TECHNIQUES   Vol. 4 ( 3 ) page: 185 - 188   2018.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jvscit.2018.03.011

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  25. Anatomical Suitability of the GORE EXCLUDER Iliac Branch Endoprosthesis in Japanese Patients with Common Iliac Aneurysms Treated by Standard EXCLUDER Endografts

    Sugimoto Masayuki, Takahashi Noriko, Niimi Kiyoaki, Kodama Akio, Banno Hiroshi, Komori Kimihiro

    ANNALS OF VASCULAR SURGERY   Vol. 50   page: 179 - 185   2018.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.avsg.2017.11.071

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  26. Aneurysm Sac Thrombus Volume Predicts Endoleak With Aneurysm Expansion After Endovascular Aneurysm Repair

    Fujii Takayuki, Banno Hiroshi, Takahashi Noriko, Sugimoto Masayuki, Niimi Kiyoaki, Komori Kimihiro

    JOURNAL OF VASCULAR SURGERY   Vol. 67 ( 6 ) page: E80 - E80   2018.6

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  27. Long-term fate of renal function after open surgery for juxtarenal and pararenal aortic aneurysm

    Sugimoto Masayuki, Takahashi Noriko, Niimi Kiyoaki, Kodama Akio, Banno Hiroshi, Komori Kimihiro

    JOURNAL OF VASCULAR SURGERY   Vol. 67 ( 4 ) page: 1042 - 1050   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jvs.2017.07.121

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  28. Association Between Preoperative Frailty and Mortality in Patients With Critical Limb Ischemia Following Infrainguinal Bypass Surgery - Usefulness of the Barthel Index -

    Kodama Akio, Koyama Akio, Sugimoto Masayuki, Niimi Kiyoaki, Banno Hiroshi, Komori Kimihiro

    CIRCULATION JOURNAL   Vol. 82 ( 1 ) page: 267 - 274   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-17-0369

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  29. Long-term Comparison of Endovascular and Open Repair of Abdominal Aortic Aneurysms: Retrospective Analysis of Matched Cohorts with Propensity Score

    Sugimoto Masayuki, Koyama Akio, Niimi Kiyoaki, Kodama Akio, Banno Hiroshi, Komori Kimihiro

    ANNALS OF VASCULAR SURGERY   Vol. 43   page: 96 - 103   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.avsg.2017.01.011

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  30. The impact of inflow treatment for claudicants with both aortoiliac and femoropopliteal occlusive disease

    Maekawa Takashi, Komori Kimihiro, Kodama Akio, Banno Hiroshi, Narita Hiroshi, Sugimoto Masayuki

    SURGERY TODAY   Vol. 47 ( 3 ) page: 293 - 300   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00595-016-1399-0

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  31. The Relationship between Temporal Changes in Proximal Neck Angulation and Stent-Graft Migration after Endovascular Abdominal Aortic Aneurysm Repair

    Tokunaga Seisaku, Ihara Tsutomu, Banno Hiroshi, Kodama Akio, Sugimoto Masayuki, Komori Kimihiro

    ANNALS OF VASCULAR SURGERY   Vol. 39   page: 119-127   2017.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.avsg.2016.05.128

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  32. Relationship between the distal migration and length of the distal landing zone after endovascular aneurysm repair (EVAR). Reviewed

    Ihara T, Komori K, Banno H, Kodama A, Yamamoto K, Sugimoto M

    Surgery Today   Vol. 46 ( 1 ) page: 56-61   2016.1

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  33. Who should do endovascular repair of complex aortic aneurysms and how should they do them? Invited Reviewed

    Banno H, Marzelle J, Becquemin JP.

    Surgeon   Vol. 13 ( 5 ) page: 286-291   2015.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  34. Pre- and Intraoperative Predictors of Delirium after Open Abdominal Aortic Aneurysm Repair.

    Sugimoto M, Kodama A, Narita H, Banno H, Yamamoto K, Komori K

    Annals of Vascular Disease   Vol. 8 ( 3 ) page: 215-9   2015.7

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  35. The fate of ischemic limbs in patients with Buerger's disease based on our 30-year experience: does smoking have a definitive impact on the late loss of limbs? Reviewed

    Sugimoto M, Miyachi H, Morimae H, Kodama A, Narita H, Banno H, Yamamoto K, Komori K.

    Surgery Today   Vol. 45 ( 4 ) page: 466-470   2015.4

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  36. Real chimney technique for total debranching of supra-aortic trunks. Reviewed

    Kato M, Kagaya H, Kubo Y, Banno H, Ohkubo N.

    Journal of Vascular Surgery   Vol. 61 ( 2 ) page: 542-5   2015.2

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  37. Possible involvement of Notch signaling in the pathogenesis of Buerger's disease. Reviewed

    Tamai H, Kobayashi M, Takeshita K, Kodama A, Banno H, Narita H, Yamamoto K, Komori K.

    Surgery Today   Vol. 44 ( 1 ) page: 307-13   2014

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  38. Inter-observer variability in sizing fenestrated and/or branched aortic stent-grafts. Reviewed

    Banno H, Kobeiter H, Brossier J, Marzelle J, Presles E, Becquemin JP

    European journal of Vascular and Endovascular Surgery   Vol. 47 ( 1 ) page: 45-52   2014

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  39. Comparison of fenestrated endovascular aneurysm repair and chimney graft techniques for pararenal aortic aneurysm. Reviewed

    Banno H, Cochennec F, Marzelle J, Becquemin JP.

    Journal of Vascular Surgery   Vol. 60 ( 1 ) page: 31-9   2014

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  40. Post-stress perfusion abnormalities detected on myocardial perfusion single-photon emission computed tomography predict long-term mortality after elective abdominal aortic aneurysm repair. Reviewed

    Inoue Y, Yoshikawa D, Ishii H, Isobe S, Kumagai S, Suzuki S, Okumura S, Hayashi M, Matsubara T, Ohshima S, Banno H, Komori K, Kato K, Murohara T.

    Circulation Journal   Vol. 77 ( 5 ) page: 1229-34   2013

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  41. Three-dimensional workstation is useful for measuring the correct size of abdominal aortic aneurysm diameters. Reviewed

    Ihara T, Komori K, Yamamoto K, Kobayashi M, Banno H, Kodama A.

    Annals of Vascular Surgery   Vol. 27 ( 2 ) page: 154-61   2013

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  42. Acute Lower Extremity Ischemia due to the Popliteal Pseudoaneurysm in a 16-year-old Boy with Multiple Exostoses. Reviewed

    Banno H, Houbballah R, Becquemin JP.

    Annals of Vascular Disease   Vol. 6 ( 2 ) page: 215-217   2013

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  43. Cost disparity between open repair and endovascular aneurysm repair for abdominal aortic aneurysm: a single-institute experience in Japan. Reviewed

    Morimae H, Maekawa T, Tamai H, Takahashi N, Ihara T, Hori A, Narita H, Banno H, Kobayashi M, Yamamoto K, Komori K.

    Surgery Today   Vol. 42 ( 2 ) page: 121-6   2012

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  44. Surgical experience of 13 infected infrarenal aortoiliac aneurysms: preoperative control of septic condition determines early outcome. Reviewed

    Sugimoto M, Banno H, Idetsu A, Matsushita M, Ikezawa T, Komori K.

    Surgery   Vol. 149 ( 5 ) page: 699-704   2011.5

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  45. Relationship between the diameter of the vein graft and postoperative ankle brachial pressure index following femoro-popliteal bypass. Reviewed

    Matsushita M, Ikezawa T, Banno H.

    Int Angiol   Vol. 27 ( 4 ) page: 329-332   2008.8

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  46. Pitavastatin inhibits intimal hyperplasia in rabbit vein graft. Reviewed

    Fujita H, Banno H, Yamanouchi D, Kobayashi M, Yamamoto K, Komori K.

    J Surg Res   Vol. 148 ( 2 ) page: 238-43   2007.10

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  47. Controlled release of small interfering RNA targeting midkine attenuates intimal hyperplasia in vein grafts.

    Banno H, Takei Y, Muramatsu T, Komori K, Kadomatsu K.

    Journal of Vascular Surgery   Vol. 46 ( 1 ) page: 116-23   2007.7

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  48. Celiprolol reduces the intimal thickening of autogenous vein grafts via an enhancement of nitric oxide function through an inhibition of superoxide production. Reviewed

    Hattori K, Yamanouchi D, Banno H, Kobayashi M, Yamamoto K, Kajikuri J, Itoh T,Komori K.

    Journal of Vascular Surgery   Vol. 46 ( 1 ) page: 113-23   2007.7

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  49. Hydrophilic statin suppresses vein graft intimal hyperplasia via endothelial cell-tropic Rho-kinase inhibition. Reviewed

    Yamanouchi D, Banno H, Nakayama M, Sugimoto M, Fujita H, Kobayashi M, KuwanoH, Komori K.

    Journal of Vascular Surgery   Vol. 42 ( 4 ) page: 757-64   2005.10

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  50. Antisense oligodeoxyribonucleotide as to the growth factor midkine suppresses neointima formation induced by balloon injury. Reviewed

    Hayashi K, Banno H, Kadomatsu K, Takei Y, Komori K, Muramatsu T.

    Am J Physiol Heart Circ Physiol   Vol. 288 ( 5 ) page: 2203-9   2005.1

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  51. External iliac venous aneurysm in a pregnant woman: a casereport. Reviewed

    Banno H, Yamanouchi D, Fujita H, Nagata J, Kobayashi M, Matsushita M, Nishikimi N, Komori K.

    Journal of Vascular Surgery   Vol. 40 ( 1 ) page: 174-8   2004.7

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Books 3

  1. 血行再建術のガイドラインを識る

    坂野比呂志, 古森公浩( Role: Sole author)

    Heart View  2011.4 

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    Language:Japanese

  2. 【大動脈瘤診療のめざましい進歩】 手術かステントグラフトか

    坂野比呂志, 古森公浩( Role: Sole author)

    臨牀と研究  2010.11 

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    Language:Japanese

  3. 大動脈瘤疾患と血液凝固線溶との関連

    坂野比呂志, 古森公浩( Role: Sole author)

    日本血栓止血学会誌  2006.2 

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    Language:Japanese

KAKENHI (Grants-in-Aid for Scientific Research) 13

  1. 胸部大動脈ステントグラフト内挿術後脊髄障害発症機序の解明と新規予防戦略の展開

    Grant number:21K08840  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    坂野 比呂志, 古森 公浩, 児玉 章朗, 新美 清章, 杉本 昌之, 川井 陽平

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    胸部下行大動脈瘤に対する外科的人工血管置換術(以下,OSR)では血流低下により脊髄虚血(以下,SCI)が発症することが知られているが,ステントグラフト内挿術(以下,TEVAR)では脆弱な大動脈壁在血栓の微小塞栓によりSCIが起こるという仮説を立て,自験例で証明した(J Vasc Surg 2020 in press).しかし残念ながら自験例のみでは十分な検討を行うには症例数が不足している.本研究の目的は,多施設共同研究による大規模データを用いて胸部下行大動脈壁在血栓の性状とTEVAR後SCIの発症の関連を調べ,今後の予防戦略に関するエビデンスを構築することにある.

  2. ロイコトリエン-リポキシゲナーゼ代謝系をターゲットとした新規血管病治療の探索研究

    Grant number:21K08839  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    川井 陽平, 古森 公浩, 坂野 比呂志, 児玉 章朗, 杉本 昌之, 新美 清章

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    動脈硬化性疾患は、慢性炎症が関与していることが知られている。近年、気管支喘息の治療で用いられるロイコトリエン拮抗薬が心血管疾患に対する新たな創薬として標的となっている。動脈硬化において、ロイコトリエン-リポキシゲナーゼ系代謝物がマクロファージに作用することで炎症性作用を惹起し、動脈硬化の進展に寄与していることが報告されている。これを阻害するロイコトリエン拮抗薬が動脈硬化性疾患に対する新規治療戦略になりうる。
    本研究の意義は、ロイコトリエン-リポキシゲナーゼ代謝系を抑制する薬物の血管病に関連する抗炎症作用に関して検討し、動脈瘤、閉塞性動脈硬化症に対する新たな治療戦略を提唱することにある。

  3. 大動脈瘤抑制のための血流改変モデルの解析

    Grant number:21K08841  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    新美 清章, 古森 公浩, 坂野 比呂志, 児玉 章朗

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    Authorship:Coinvestigator(s) 

    腹部大動脈瘤は下肢の動脈瘤も含め、動脈の分岐点で乱流の生じやすい部位に好発し、腹部大動脈瘤は多くは大動脈分岐上、総腸骨動脈瘤や総大腿動脈瘤も同様に分岐直上にできる。一方、直線状になっている外腸骨動脈や浅大腿動脈の瘤化はほとんどない。本研究の目的は、大動脈瘤抑制のための血流改変モデルを作製解析することで腹部大動脈瘤形成および進展のメカニズムを明らかにし、その上で新たな血管病の治療戦略を呈示することにある。

  4. 亜鉛をターゲットとした閉塞性動脈硬化症に対する新しい治療戦略

    Grant number:20K09123  2020.4 - 2023.3

    科学研究費助成事業  基盤研究(C)

    古森 公浩, 坂野 比呂志, 児玉 章朗, 新美 清章, 杉本 昌之

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    亜鉛は生命体における必須ミネラルで、近年亜鉛欠乏と動脈硬化との関連が報告されている。また我々は重症下肢虚血における下肢バイパス術の臨床的検討において亜鉛欠乏群では、正常群に比べバイパス開存率・救肢率・Amputation free survaival・創傷治癒率は不良であることを世界で初めて報告した。亜鉛欠乏と血管内膜肥厚および下肢虚血作成後の血管新生反応に及ぼす影響についての検討は、これまでになされていない。本研究の目的は、亜鉛欠乏モデルに関して検討し閉塞性動脈硬化症(ASO)に対する新規治療戦略を提唱することにある。
    【目的】
    亜鉛欠乏は、創傷治癒遅延、心血管障害など、様々な障害を引き起こすことが知られている。我々は重症虚血肢患者の亜鉛欠乏群は亜鉛正常群に比べ救肢率、創傷治癒率、いずれも有意差をもって低値であることを既に報告している。今回、我々はその機序解明のため、マウスモデルを用いて亜鉛欠乏が血管新生能に与える影響を検討した。
    【方法】
    野生型マウスに亜鉛欠乏食を週令3週より投与し、亜鉛欠乏モデルを作成。亜鉛欠乏(ZD)群と対照(C)群について、週令10週で左大腿動脈を結紮し、虚血肢を作成。虚血後の血管新生能を、1.レーザードップラー法(LDBF)による虚血肢/健肢の血流を比較した。
    【結果】
    ZD群では、筋線維中のDHEの発色が増強し、血中D-ROM濃度も有意に増加した。LDBFにて測定した虚血肢/健肢血流比が、C群と比較し、術後14日目以降有意に低下していた。毛細血管密度もZD群が有意に低かった。
    順調に進んでいる。
    今後は、1. 筋線維中の毛細血管密度をCD31免疫染色にて定量評価。2. 活性酸素種の検出を目的としてジヒドロエチジウム(DHE)染色と血中D-ROM濃度の測定を行い、NADPH oxidase(Nox)のサブユニットをRT-PCRで解析。3. 抗酸化剤投与の影響を検討するため、ZD群へアポシニンを経口投与してLDBFを比較する予定である。

  5. Exploratory research of novel management targeting Xa inhibitor for vascular diseases

    Grant number:18K08728  2018.4 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    BANNO Hiroshi

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    Aneurysm model: Xa inhibitor was administered to mouse ascites-derived macrophages and gene expression analysis was performed. Apixaban administration suppressed MCP-1 expression, and edoxaban administration significantly increased TNF-α, IL-1b, IL-6, cathepsin K, and S gene expression. Therefore, apixaban and edoxaban were administered to the mouse aneurysm model, but the aneurysm-suppressing effect was not confirmed. On the contrary, anal bleeding was observed at all concentrations as a possible side effect.
    Intimal hyperplasia model: A bypass model using the external jugular vein as a graft was created using rabbits. The intimal hyperplasia was evaluated by classifying into the edoxaban-administered group and the non-administered group, but no significant difference was observed between the two groups.

  6. Potent Inhibiting Effect of Activated vitamine D3 on Aortic Aneurysm Dilatation

    Grant number:17K10753  2017.4 - 2020.3

    NIIMI Kiyoaki

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    The activity of endogenous MCP-1 was significantly lower in the calsitriol group than in the Saline group. However, there was no significant difference in expression level of IL-1βand MMP-9 causing degeneration of the extracellular matrix between the Saline and calsitriol groups. In that series, we decided to evaluate another anti-inflammatory subject that can suppress atherosclerotic disease. Montelukast is a selective CVS-LT-1receptor antagonist that could surpress atherosclerotic diseases. We evaluated the in vitro properties of montelukast and its in vivo activities in an angiotensinⅡ-infused apolipoprotein E-deficient AAA mouse model. Relative to control,montelukast significantly suppressed gene expression of MMP-2, MMP-9, and IL-1β.In vivo,montelukast significantly decreased aortic expansion and induced infiltration of M2 macrophages.

  7. Functions of Nitric Oxide and Endothelium-derived Hyperpolarizing Factor are impaired in Poor Run-off Autogenous Rabbit Arterial Grafts

    Grant number:17H04290  2017.4 - 2020.3

    KOMORI Kimihiro

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    Background: Vascular endothelium induces smooth muscle cell (SMC) relaxation mainly mediated by endothelium-derived nitric oxide (EDNO) and endothelium-derived hyperpolarizing factor (EDHF). The present study was undertaken to determine whether the functions of EDNO and EDHF might be altered in poor run-off artery graft compared to “non-occluded graft”. Methods: The carotid artery was excised and implanted in its original position as an autogenous graft(“non-occluded graft”), and the most inferior branch of the external carotid artery served as the only outflow for the present conditions (“poor run-off graft”).
    Conclusions: The functions of both EDNO and EDHF are impaired in poor run-off artery grafts.

  8. 3D Imaging Analysis to Elucidate Predictors for Long-term results after Endovascular Aortic Aneurysm Repair

    Grant number:16K10657  2016.4 - 2019.3

    SUGIMOTO Masayuki

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    In this observational clinical study, longitudinal anatomical measurement of abdominal aortic aneurysms after endovascular repair was performed using a dedicated 3D workstation (Aquarius; TeraRecon). Statistical analysis of those anatomical factors, in combination with clinical data, has revealed: 1) specific clinical backgrounds of our series in comparison with other large clinical studies, 2) several predictors for long-term outcomes such as aneurysmal shrinkage. Notably, our study has elucidated new insights about predictors for type II endoleak and resulting aneurysm enlargement.

  9. Impact of Clopidogrel and Prasugrel on suppression of autogenous vein graft.

    Grant number:15K10240  2015.4 - 2018.3

    KODAMA Akio

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    We performed reversed vein graft under normal and poor run-off model. At first some of grafted veins were occluded because of technical problems, thereby, it was difficult to evaluate the effects of Clopidogrel and Prasugrel. Finally the technical problems were resolved. At the same time we tried to search the optimal administration methods and dosage of these drugs. However, we could not to find them. Therefore, we made some grafted veins of Edoxaban-treated rabbits. The assessment of intimal hyperplasia did not show significant differences in their lumen area, intimal thickness, medial thickness, and intima/media index between control grafted veins and Edoxaban-treated grafted veins.

  10. 血管内膜肥厚の成因とその制御-EDHFをターゲットとした新しい探索研究-

    2013.4 - 2015.3

    科学研究費補助金  基盤研究(B)

  11. 糖尿病治療薬をターゲットとした新しい血管病治療の探索研究

    2012.4 - 2013.3

    科学研究費補助金 

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  12. CT画像解析によるステントグラフト形態の変化の分析

    2010.4 - 2012.3

    科学研究費補助金  基盤研究(C)

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  13. ステント内膜肥厚抑制の新しいアプローチ −Ezetimibeの効果検証

    2010.4 - 2012.3

    科学研究費補助金  基盤研究(C)

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