2025/03/18 更新

写真a

マツシマ マサヤ
松島 正哉
MATSUSHIMA, Masaya
所属
医学部附属病院 放射線科 病院講師
職名
病院講師

学位 1

  1. 博士(医学) ( 2010年9月   名古屋大学 ) 

 

論文 17

  1. "Speckled Enhancement" on Gd-EOB-DTPA Enhanced MR Imaging of Primary Hepatic Mucosa-associated Lymphoid Tissue Lymphoma Open Access

    Hyodo, R; Takehara, Y; Nishida, A; Matsushima, M; Naganawa, S

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   22 巻 ( 3 ) 頁: 273 - 281   2023年

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    記述言語:英語   出版者・発行元:日本磁気共鳴医学会  

    Purpose: To elucidate MRI features of primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma, particularly, the “speckled enhancement” on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI. Methods: The institutional review board approved this retrospective observational study and waived informed consent. Using our picture archiving and communication systems and electronic medical records, five patients histopathologically diagnosed as hepatic MALT lymphoma and clinically confirmed as primary lesions who had undergone dynamic contrast-enhanced (DCE)-CT and DCE-MRI with Gd-EOB-DTPA were identified from September 2009 to December 2020. Two radiologists assessed their CT and MRI data in consensus with a pathologist’s advice. Results: Overall, five lesions in five patients were included in this study. Precontrast CT showed hypoatte-nuation in all lesions. In the arterial phase of DCE-CT, four lesions (80%) showed hyperattenuation, whereas all lesions showed iso-to hypoattenuation in the delayed phase. A vessel penetration sign was also observed in all lesions. On MRI, all lesions showed hypointensity on T1-weighted images, hyperintensity on T2-weighted images, and restricted diffusion on diffusion-weighted images. Both DCE-CT and DCE-MRI with Gd-EOB-DTPA showed similar enhancement patterns, except for the hepatocyte phase. Notably, how-ever, four out of five lesions showed characteristic “speckled enhancement” that refers to punctate positive enhancements within the low signal lesions on the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI pathologically confirmed to be hepatocyte clusters that remained in the tumor. Conclusion: Primary hepatic MALT lymphomas were characterized by arterial phase enhancement, restricted diffusion, vessel penetration sign, and more specifically “speckled enhancement” in the hepato-biliary phase of DCE-MRI with Gd-EOB-DTPA.

    DOI: 10.2463/mrms.mp.2021-0069

    Open Access

    Web of Science

    Scopus

    PubMed

    CiNii Research

  2. Embolization using patient-specific vascular models created by a 3D printer for difficult cases: a report of two cases

    Komada, T; Kamomae, T; Matsushima, M; Hyodo, R; Naganawa, S

    NAGOYA JOURNAL OF MEDICAL SCIENCE   84 巻 ( 2 ) 頁: 477 - 483   2022年5月

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    記述言語:英語   出版者・発行元:Nagoya Journal of Medical Science  

    With the widespread use of three-dimensional printers, organ models created by these printers are now being used in the medical field for preoperative planning of surgeries. In this article, we report two cases in which embolization was expected to be difficult, and the three-dimensional printer-based vascular modeling was helpful in planning the surgery. The first case involved an aneurysm of the splenic artery. We attempted to embolize the aneurysm but were unable to advance the catheter into the distal artery and discontinued the procedure. The second case was a perianal varicose vein, which was initially treated with percutaneous transhepatic obliteration but was recanalized and required embolization. However, we expected difficulty in selecting the inferior mesenteric vein. In both cases, the vascular models were created using a 3D printer from the patients’ computed tomography images. Preoperative planning, including treatment simulation, was based on these models. The time required to print a three-dimensional vascular model was approximately 12 hours at a cost of less than $10 each. Patient-specific vascular models using a three-dimensional printer can be a simple and inexpensive tool that can increase the success of embolization in difficult cases.

    DOI: 10.18999/nagjms.84.2.477

    Web of Science

    Scopus

    PubMed

  3. A case of stent-graft implantation for postpancreaticoduodenectomy hemorrhage in a patient with a reconstructed gastric tube. Open Access

    Komada T, Tachi Y, Nagasaka K, Yamada S, Matsushima M, Sakaki Y, Naganawa S

    Radiology case reports   15 巻 ( 12 ) 頁: 2710 - 2713   2020年12月

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    記述言語:英語   出版者・発行元:Radiology Case Reports  

    In patients with a reconstructed gastric tube, the right gastroepiploic artery is a very important feeding artery of the tube, which must be preserved when performing a pancreaticoduodenectomy. A 76-year-old man with a reconstructed gastric tube underwent pancreaticoduodenectomy for distal bile duct carcinoma. On postoperative day 8, he had an arterial hemorrhage from a drain, apparently from a ligation of the anterior superior duodenal artery. He, therefore, underwent stent-graft placement in the gastroduodenal artery. The stent-grafts were temporarily occluded, and the gastric tube was necrotizing. However, thrombolytic therapy allowed the stent-grafts to reopen and prevented gastric tube necrosis. We believe our case of stent-graft implantation in the gastroduodenal artery is the first of this kind to successfully prevent lethal necrosis of the gastric tube.

    DOI: 10.1016/j.radcr.2020.10.021

    Open Access

    Scopus

    PubMed

  4. Evaluation of segment 4 portal vein embolization added to right portal vein for right hepatic trisectionectomy: A retrospective propensity score-matched study

    Ito, J; Komada, T; Suzuki, K; Matsushima, M; Nakatochi, M; Kobayashi, Y; Ebata, T; Naganawa, S; Nagino, M

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   27 巻 ( 6 ) 頁: 299 - 306   2020年6月

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    記述言語:英語   出版者・発行元:Journal of Hepato-Biliary-Pancreatic Sciences  

    Background: Adding segment 4 (S4) portal vein embolization (PVE) to right PVE before right hepatic trisectionectomy is controversial. We retrospectively examined the effect of S4 PVE on segments 2 and 3 (S2 + 3) hypertrophy. Methods: We reviewed patients with biliary carcinoma who underwent right PVE with (R3PVE) or without (R2PVE) S4 PVE using gelatin sponge particles and coils (2010-2019). Propensity score matching balanced the cohort for baseline characteristics, including total liver volume and S2 + 3 volume before PVE. We compared the groups regarding the S2 + 3 volume changes after PVE. Results: Of 178 enrolled patients, 38 underwent R3PVE for right hepatic trisectionectomy and 140 underwent R2PVE for right hepatectomy. Twenty-eight patients from each group were respectively matched. The median absolute volume increase in (146 cm3 vs 70 cm3), hypertrophy rate of (52.4% vs 32.3%), and kinetic growth rate of (3.1%/wk vs 2.0%/wk) S2 + 3 were significantly higher in the R3PVE group than in the R2PVE group. In the pre-matched cohort, the rate of posthepatectomy liver failure and postoperative hospital stay did not significantly differ between the patients who underwent right hepatic trisectionectomy and right hepatectomy. Conclusion: R3PVE increased the S2 + 3 volume more effectively than R2PVE in patients with biliary carcinoma.

    DOI: 10.1002/jhbp.723

    Web of Science

    Scopus

    PubMed

  5. Balloon-Occluded Retrograde Transvenous Obliteration for Fundal Gastric Variceal Bleeding in a Small Child

    Komada, T; Suzuki, K; Oshima, K; Matsushima, M; Nagasaka, K; Naganawa, S

    JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY   30 巻 ( 10 ) 頁: 1624 - 1625   2019年10月

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    記述言語:英語   出版者・発行元:Journal of Vascular and Interventional Radiology  

    DOI: 10.1016/j.jvir.2019.06.022

    Web of Science

    Scopus

    PubMed

▼全件表示

MISC 1

  1. A case of stent-graft implantation for postpancreaticoduodenectomy hemorrhage in a patient with a reconstructed gastric tube.

    Komada T, Tachi Y, Nagasaka K, Yamada S, Matsushima M, Sakaki Y, Naganawa S  

    Radiology case reports15 巻 ( 12 ) 頁: 2710 - 2713   2020年12月

     詳細を見る

    記述言語:英語   出版者・発行元:Radiology Case Reports  

    In patients with a reconstructed gastric tube, the right gastroepiploic artery is a very important feeding artery of the tube, which must be preserved when performing a pancreaticoduodenectomy. A 76-year-old man with a reconstructed gastric tube underwent pancreaticoduodenectomy for distal bile duct carcinoma. On postoperative day 8, he had an arterial hemorrhage from a drain, apparently from a ligation of the anterior superior duodenal artery. He, therefore, underwent stent-graft placement in the gastroduodenal artery. The stent-grafts were temporarily occluded, and the gastric tube was necrotizing. However, thrombolytic therapy allowed the stent-grafts to reopen and prevented gastric tube necrosis. We believe our case of stent-graft implantation in the gastroduodenal artery is the first of this kind to successfully prevent lethal necrosis of the gastric tube.

    DOI: 10.1016/j.radcr.2020.10.021

    Scopus

    PubMed

科研費 1

  1. 肝内門脈側副路の評価と肝静脈塞栓を組み込んだ拡大肝切除のためのIVRの新戦略

    研究課題/研究課題番号:21K07562  2021年4月 - 2025年3月

    科学研究費助成事業  基盤研究(C)

    駒田 智大, 松島 正哉, 長坂 憲, 馬越 弘泰

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    担当区分:研究分担者 

    門脈塞栓術は、拡大肝切除術前に切除予定部分の肝内門脈を塞栓し、残存予定部分の肝臓を肥大させることで、術後の肝不全を予防するIVRである。
    本研究の目的は、門脈塞栓術の前後で、Dual energy CTを搭載したIVR-CTで、門脈造影による肝実質ヨードマップを作製し、肝実質内のヨード濃度を計測することで、肝内門脈側副路の影響を調べ、残存予定葉の肥大との相関を明らかにすることである。また十分な残肝肥大が得られないと予想される症例に対して、肝静脈塞栓術を追加することで、肝肥大を向上させることができるかを明らかにする。
    門脈塞栓術は、拡大肝切除術前に切除予定部分の肝内門脈を塞栓し、残存予定部分の肝臓を肥大させることで、術後の肝不全を予防するIVRである。我々が門脈塞栓術を行った136症例の残存予定葉の肥大率は、30.7%であったが、ほとんど肥大していない症例もあった。
    残存予定葉の肥大に影響する様々な因子が知られているが、門脈血流そのものを検討した研究はなされていない。近年、Dual energy CTを搭載したIVR-CTで、門脈造影による肝実質ヨードマップを作製することで、肝実質内の門脈血流を客観的に評価できるようになった。
    本研究の目的は、門脈塞栓術の前後で、門脈造影による肝実質ヨードマップを作製し、肝実質内のヨード濃度を計測することで、肝内門脈側副路の影響を調べ、残存予定葉の肥大との相関を明らかにすることである。また十分な残肝肥大が得られないと予想される症例に対して、肝静脈塞栓術を追加することで、肝肥大を向上させることができるかを明らかにする。
    これにより肝癌や胆管癌の手術適応が拡大し、予後の改善が期待できる見込みである。
    まず、研究を始めるにあたり、施設の生命倫理審査委員会に研究の申請を行い、承認を受けた。現在、対象患者さんに対して、インフォームドコンセントを行い、了解を得たのちに、研究に参加していただき、門脈塞栓術時に門脈造影を行いながらDual energy CTの撮影を行い、門脈血流による肝ヨードマップのデータの採取を行っている。
    中間解析を行った結果、対象となる症例を限定することになったため、想定より症例の集積のペースが落ちてしまった。
    現在、拡大肝切除術前に経皮的門脈塞栓術を行っている患者さんに対して、インフォームドコンセントを行い、署名による同意を得たのちに、門脈造影によるDual energy CTの撮影を行わせていただき、データの蓄積を行っている。
    中間解析を行った結果では、予想と矛盾しない結果であった。さらに症例数を増やして、再検討する予定である。