Updated on 2024/03/21

写真a

 
TAINAKA, Takahisa
 
Organization
Nagoya University Hospital Children's Cancer Center Lecturer of hospital
Title
Lecturer of hospital
Homepage
https://www.med.nagoya-u.ac.jp/medical_J/laboratory/clinical-med/surgery/pediatric-surg/
External link

Degree 2

  1. 博士（医学） （ 2007.3   名古屋大学 ） 

  2. 学士（医学） （ 1999.3   福島県立医科大学 ） 

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Research Interests 4

  1. Pediatric Surgery

  2. 低侵襲手術　内視鏡外科

  3. 胆道閉鎖症

  4. 横隔膜ヘルニア 再生医療

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Research Areas 2

  1. Life Science / General surgery and pediatric surgery  / Pediatric Surgery

  2. Life Science / General surgery and pediatric surgery

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Current Research Project and SDGs 3

  1. 低侵襲手術

  2. 医工連携

  3. 再生医療

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Research History 7

  1. Nagoya University   Lecturer of hospital

    2022.10

  2. Nagoya University   Lecturer of hospital

    2018.7 - 2021.3

  3. 埼玉県立小児医療センター   小児外科   医長

    2017.10 - 2018.6

  4. Nagoya University   Lecturer of hospital

    2014.7 - 2017.9

  5. Aichi Medical University   Designated associate professor

    2012.2 - 2014.6

  6. Nagoya University   Assistant professor of hospital

    2007.7 - 2012.1

  7. Nagoya University

    2004.4 - 2007.6

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Professional Memberships 7

  1. 日本外科学会

  2. 日本小児外科学会   保険診療委員会

  3. 日本内視鏡外科学会

  4. 日本小児血液・がん学会

  5. 日本周産期新生児医学会

  6. The Pacific Association of Pediatric Surgeons

  7. International Pediatric Endosurgery Group

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Committee Memberships 3

  1. 日本小児外科学会   保険診療委員会  

    2021.6   

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    Committee type：Academic society

  2. 日本小児外科学会   トランジション委員会  

    2017.6 - 2021.5   

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    Committee type：Academic society

  3. 日本小児外科学会   小児救急検討委員会  

    2015.6 - 2019.5   

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    Committee type：Academic society

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Awards 2

  1. 日本小児外科学会優秀論文賞

    2004   日本小児外科学会  

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    Country：Japan

  2. 日本小児外科学会優秀論文賞

    2002   日本小児外科学会  

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    Country：Japan

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Papers 104

  1. Surgical Strategies for Neonates with Prenatally Diagnosed Congenital Biliary Dilatation

    Shirota, C; Hinoki, A; Tainaka, T; Sumida, W; Makita, S; Amano, H; Takimoto, A; Yasui, A; Nakagawa, Y; Liu, JH; Guo, YH; Kato, D; Goda, Y; Maeda, T; Uchida, H

    JOURNAL OF PEDIATRIC SURGERY   Vol. 59 ( 3 ) page： 385 - 388   2024.3

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    Language：English   Publisher：Journal of Pediatric Surgery  

    Background: This study aimed to develop a postnatal treatment strategy for infants with prenatally diagnosed congenital biliary dilatation. Methods: We performed a retrospective study of patients with prenatal diagnosed congenital biliary dilatation (CBD), aged <1 year who underwent surgery at our hospital between 2013 and 2023. We classified the patients into two groups, the “early group,” consisting of patients who could not wait for growth, and required early surgery, and the “scheduled group,” consisting of patients who were asymptomatic and could undergo scheduled surgery, and compared them. The parameters for early surgical prediction were AST, ALT, TB, DB, and CRP levels at birth, 1 week, 2 weeks, 1 month, 2 months, and 3 months after birth, and immediately before surgery, as well as the cyst diameter, presence of intrahepatic bile duct dilation, and presence of debris in the common bile duct. Results: During the study period, 15 patients were diagnosed prenatally. The cyst diameter was significantly larger at all points in the early group. Patients with a cyst diameter of >30 mm at birth, intrahepatic bile duct dilatation at birth, and postnatal enlargement of the common bile duct to >30 mm are more likely to develop symptoms early. Blood biochemistry tests showed no significant differences between the two groups. Conclusions: Patients with a cyst diameter >30 mm in the early postnatal period require careful postnatal management and parents should be counseled regarding the high likelihood of their child needing surgery within the first 3 months of life. Level of evidence: Level IV.

    DOI： 10.1016/j.jpedsurg.2023.10.045

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  2. Scoring system for diagnosis and pretreatment risk assessment of neuroblastoma using urinary biomarker combinations.

    Amano H, Uchida H, Harada K, Narita A, Fumino S, Yamada Y, Kumano S, Abe M, Ishigaki T, Sakairi M, Shirota C, Tainaka T, Sumida W, Yokota K, Makita S, Karakawa S, Mitani Y, Matsumoto S, Tomioka Y, Muramatsu H, Nishio N, Osawa T, Taguri M, Koh K, Tajiri T, Kato M, Matsumoto K, Takahashi Y, Hinoki A

    Cancer science     2024.2

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    Language：English   Publisher：Cancer Science  

    The urinary catecholamine metabolites, homovanillic acid (HVA) and vanillylmandelic acid (VMA), are used for the adjunctive diagnosis of neuroblastomas. We aimed to develop a scoring system for the diagnosis and pretreatment risk assessment of neuroblastoma, incorporating age and other urinary catecholamine metabolite combinations. Urine samples from 227 controls (227 samples) and 68 patients with neuroblastoma (228 samples) were evaluated. First, the catecholamine metabolites vanillactic acid (VLA) and 3-methoxytyramine sulfate (MTS) were identified as urinary marker candidates through comprehensive analysis using liquid chromatography–mass spectrometry. The concentrations of these marker candidates and conventional markers were then compared among controls, patients, and numerous risk groups to develop a scoring system. Participants were classified into four groups: control, low risk, intermediate risk, and high risk, and the proportional odds model was fitted using the L2-penalized maximum likelihood method, incorporating age on a monthly scale for adjustment. This scoring model using the novel urine catecholamine metabolite combinations, VLA and MTS, had greater area under the curve values than the model using HVA and VMA for diagnosis (0.978 vs. 0.964), pretreatment risk assessment (low and intermediate risk vs. high risk: 0.866 vs. 0.724; low risk vs. intermediate and high risk: 0.871 vs. 0.680), and prognostic factors (MYCN status: 0.741 vs. 0.369, histology: 0.932 vs. 0.747). The new system also had greater accuracy in detecting missing high-risk neuroblastomas, and in predicting the pretreatment risk at the time of screening. The new scoring system employing VLA and MTS has the potential to replace the conventional adjunctive diagnostic method using HVA and VMA.

    DOI： 10.1111/cas.16116

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  3. Laparoscopic Fundoplication in Patients with Ventriculoperitoneal Shunts: A Systematic Review and Our Experience

    Kato, D; Uchida, H; Tainaka, T; Amano, H; Ono, Y; Yasui, A; Shirota, C; Sumida, W; Yokota, K; Makita, S; Takimoto, A; Takada, S; Nakagawa, Y; Gohda, Y; Maeda, T; Hinoki, A

    JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES   Vol. 34 ( 3 ) page： 268 - 273   2024.1

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    Language：English   Publisher：Journal of Laparoendoscopic and Advanced Surgical Techniques  

    Background: Data on the outcomes of laparoscopic fundoplication (LF) in patients with ventriculoperitoneal (VP) shunts are limited. Materials and Methods: We retrospectively evaluated the demographic characteristics and outcomes of patients who underwent LF at our institutions between 2014 and 2022. Then, we systematically reviewed articles in MEDILINE/PubMed, Cochrane Library, and Web of Science. Results: There was no significant difference in terms of the outcomes between patients with VP shunt (n = 10) and those without (n = 96) at our institutions. None of the patients presented with shunt trouble after LF. The meta-analysis included four retrospective studies and our institutional data. In total, 605 patients (55 with VP shunt) underwent LF. Furthermore, 2 (3.6%) of 55 patients (1 with infection and 1 with occlusion) had shunt troubles. The conversion and complication rates, operative time, and length of hospital stay did not significantly differ between patients with VP shunt and those without. Conclusions: LF can be safely performed on children with VP shunts and is associated with a low risk of shunt troubles.

    DOI： 10.1089/lap.2023.0220

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  4. Anastomotic time was associated with postoperative complications: a cumulative sum analysis of thoracoscopic repair of tracheoesophageal fistula in a single surgeon's experience.

    Yaohui Guo, Akinari Hinoki, Kyoichi Deie, Takahisa Tainaka, Wataru Sumida, Satoshi Makita, Masamune Okamoto, Aitarou Takimoto, Akihiro Yasui, Shunya Takada, Yoichi Nakagawa, Daiki Kato, Takuya Maeda, Hizuru Amano, Hiroshi Kawashima, Hiroo Uchida, Chiyoe Shirota

    Surgery today   Vol. 53 ( 12 ) page： 1363 - 1371   2023.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    PURPOSE: This study aimed to evaluate the learning curve of thoracoscopic repair of tracheoesophageal fistula (TEF) by a single surgeon using a cumulative sum (CUSUM) analysis. METHODS: Prospective clinical data of consecutive Gross type-C TEF repairs performed by a pediatric surgeon from 2010 to 2020 were recorded. CUSUM charts for anastomosis and operating times were generated. The learning curves were compared with the effect of accumulation based on case experience. RESULTS: For 33 consecutive cases, the mean operative and anastomosis times were 139 ± 39 min and 3137 ± 1110 s, respectively. Significant transitions beyond the learning phase for total operating and anastomosis times were observed at cases 13 and 17. Both the total operating time and anastomosis time were significantly faster in the proficiency improvement phase than in the initial learning phase. Postoperative complications significantly decreased after the initial anastomosis learning phase but not after the initial total operating learning phase. CONCLUSIONS: Thoracoscopic repair of TEF is considered safe and feasible after 13 cases, where the surgeon can improve their proficiency with the total operation procedure, and 17 cases, which will enable the surgeon to achieve proficiency in anastomosis. Postoperative complications significantly decreased after gaining familiarity with the anastomosis procedure through the learning phase.

    DOI： 10.1007/s00595-023-02687-9

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  5. Preoperative management comprising tube irrigation using a trans-anal indwelling tube for infants with hirschsprung disease can allow single-stage radical surgery

    Nakagawa, Y; Uchida, H; Hinoki, A; Tainaka, T; Shirota, C; Sumida, W; Makita, S; Yokota, K; Amano, H; Yasui, A; Maeda, T; Kato, D; Gohda, Y

    BMC SURGERY   Vol. 23 ( 1 ) page： 333   2023.11

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    Background: Preoperative management of Hirschsprung’s disease (HD) is currently being conducted with the goal of performing single-stage radical surgery without ileostomy. Methods: We retrospectively reviewed HD cases between 2013 and 2022, as well as their outcomes related to preoperative management. Results: Thirty-nine patients with HD were included in this study, including short-segment HD (30 cases), long-segment HD (4 cases), and total colonic aganglionosis (5 cases). Among these 39 patients, 95% (37 of 39 patients) underwent single-stage radical surgery after management with glycerin enema use (n = 13), irrigation with tube insertion each time irrigation was performed (n = 13), and irrigation using a tube placed in the bowel (n = 11). Conclusions: Preoperative management of patients with HD allowed for single-stage surgery of long-segment HD and total colonic aganglionosis. Cases that could be managed without performing an emergency enterostomy during the neonatal period were managed with irrigation until radical surgery was performed.

    DOI： 10.1186/s12893-023-02232-y

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  6. Variations of the hepatic artery and bile duct in patients with pancreaticobiliary maljunction: Impact on postoperative outcomes

    Takada, S; Uchida, H; Hinoki, A; Shirota, C; Sumida, W; Tainaka, T; Makita, S; Takimoto, A; Nakagawa, Y; Maeda, T

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 30 ( 11 ) page： 1241 - 1248   2023.11

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    Language：English   Publisher：Journal of Hepato-Biliary-Pancreatic Sciences  

    Purpose: Preoperative comprehension of the anatomical variations of the hepatic artery and bile duct is essential for safe laparoscopic surgery for pancreaticobiliary maljunction (PBM). This study aimed to investigate the impact of anatomical variations of the hepatic artery and bile duct on surgical technique and postoperative complications. Methods: We conducted a retrospective review of patients with PBM who underwent laparoscopic surgery at our institution between January 2014 and December 2022 to investigate anatomical variations in the hepatic artery and bile duct, surgical technique, and postoperative complications. Results: We included 112 patients with PBM, with a median age of 4 years (interquartile range, 0–55). Overall, 29 of 112 patients had an aberrant right hepatic artery (ARHA) running ventral to the common hepatic duct (CHD), and they underwent hepaticojejunostomy on the ventral side of the ARHA. Additionally, eight of 112 patients had an aberrant posterior hepatic duct (APHD), which was joined to the CHD in all but one case. The presence of APHD was associated with postoperative bile leak occurrence. Conclusion: Performing hepaticojejunostomy ventral to the ARHA is important to prevent complications. Furthermore, APHD may be a risk factor for postoperative bile leak and requires careful bile duct plasty.

    DOI： 10.1002/jhbp.1381

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  7. A new criterion including the aspartate aminotransferase-to-platelet ratio index and liver and spleen stiffness to rule out varices needing treatment in children with biliary atresia: Modification of the Baveno VII criteria

    Yokoyama, S; Ishizu, Y; Honda, T; Imai, N; Ito, T; Yamamoto, K; Muto, H; Shirota, C; Tainaka, T; Sumida, W; Makita, S; Takada, S; Nakagawa, Y; Maeda, T; Nakamura, M; Ishigami, M; Uchida, H; Kawashima, H

    HEPATOLOGY RESEARCH     2023.10

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    Language：English   Publisher：Hepatology Research  

    Aims: Biliary atresia (BA) is a congestive biliary disease that develops in the neonatal period or early infancy. It may present with portal hypertension and varices needing treatment (VNT) even after successful Kasai portoenterostomy. This study aimed to stratify the risk of VNT in children and adolescents with BA. Methods: In this prospective cross-sectional study, we measured liver stiffness (LS) and spleen stiffness (SS) by two-dimensional shear wave elastography and checked for VNT endoscopically in 53 patients with BA who attended for follow-up between July 2018 and September 2022. Varices needing treatment were defined as large esophageal varices, esophageal varices of any size with red color signs, and/or gastric varices along the cardia. Results: Twenty-five patients (aged 0–18 years) had VNT. Eighteen patients met the Baveno VI criteria (LS <20 kPa; platelet count >150 000/L) and were deemed to be at low risk of VNT (spared endoscopies) while three had missed VNT (16.7%). Applying the Baveno VII criteria, which combines the SS cut-off value of 40 kPa with the Baveno VI criteria, resulted in five missed VNTs among 22 spared endoscopies (22.7%). A modification of the Baveno VII criteria using the aspartate aminotransferase-to-platelet ratio index (APRI) instead of the platelet count with cut-off values of 25 kPa, 30 kPa, and 1.04 for LS, SS, and APRI, respectively, missed only one VNT (5.0%) among 20 spared endoscopies. Conclusions: A novel diagnostic criterion that combines LS, SS, and APRI reduced the risk of missing VNT to 5% in children and adolescents with BA.

    DOI： 10.1111/hepr.13976

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  8. Safe thoracoscopic repair of recurrent congenital diaphragmatic hernia after initial open abdominal repair

    Gohda, Y; Yokota, K; Uchida, H; Shirota, C; Tainaka, T; Sumida, W; Makita, S; Takimoto, A; Takada, S; Nakagawa, Y; Maeda, T; Guo, YH; Hinoki, A

    SURGERY TODAY     2023.10

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    Language：English   Publisher：Surgery Today  

    Purpose: The optimal surgical approach for recurrent congenital diaphragmatic hernia (CDH) remains controversial. We compared the surgical outcomes of a thoracoscopic approach versus an open abdominal approach for recurrent CDH after initial abdominal open repair. Method: The subjects of this comparative study were patients who underwent open abdominal or thoracoscopic surgery for recurrent CDH following an initial open abdominal repair. Results: Among 166 patients with Bochdalek-type CDH, 15 underwent reoperation for recurrent CDH following an open abdominal repair. Seven patients underwent open abdominal surgery (group O) and eight underwent thoracoscopic surgery (group T). The operative duration was similar for the two groups, with less blood loss (17.2 ml/kg vs. 1 ml/kg, P = 0.001) and fewer intraoperative complications in the T group (n = 6 vs. n = 0 cases, P = 0.001). There was no significant difference in the number of postoperative complications (n = 1 vs. n = 1, P = 1.0) or in the number of patients with a second CDH recurrence (n = 2 vs. n = 1, P = 0.569) between the two groups. Conclusion: Thoracoscopic surgery is preferable to the open surgical approach for recurrent CDH following an initial abdominal open repair.

    DOI： 10.1007/s00595-023-02757-y

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  9. Robotic versus laparoscopic radical surgery for pediatric congenital biliary dilatation: a comparison of surgical outcomes of a single surgeon's initial experience

    Maeda, T; Liu, JH; Uchida, H; Amano, H; Shirota, C; Tainaka, T; Sumida, W; Makita, S; Takimoto, A; Takada, S; Nakagawa, Y; Gouda, A; Guo, YH; Hinoki, A

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 39 ( 1 ) page： 261   2023.9

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    Language：English   Publisher：Pediatric Surgery International  

    Purpose: This study aimed to clarify the validity of robot-assisted surgery (RAS) for pediatric patients with congenital biliary dilatation (CBD). Methods: We retrospectively compared RAS and laparoscopic surgery (LS) for pediatric CBD performed by the same certified surgeon between 2016 and 2022. Results: We included 6 RAS and 12 LS cases in this study. One case of RAS with laparotomy was excluded from the analysis. The patients in the two groups had comparable ages and body weights. The median surgery duration, the suture time per stitch, and the time to drain removal were 385 min, 145 s, and 5 days in the RAS group and 370 min (p = 0.28), 177 s (p = 0.03), and 6 days (p = 0.03) in the LS group, respectively. The time to create the Roux-en-Y limb was significantly longer in the RAS group. Postoperative complications occurred in one RAS case and in four LS cases. Conclusions: Less anastomotic time per stitch and less time to drain removal suggest that RAS may contribute to accurate suturing and fine intra-pancreatic bile duct dissection. In addition, RAS requiring large movements of forceps in a large surgical field, such as Roux-en-Y creation, is inferior to LS.

    DOI： 10.1007/s00383-023-05548-1

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  10. Management of congenital and postoperative chylothorax: Use of thoracoscopic lymphatic leak ligations with intraoperative ICG lymphangiography. International journal

    Shunya Takada, Chiyoe Shirota, Hiroo Uchida, Hizuru Amano, Akinari Hinoki, Wataru Sumida, Satoshi Makita, Masamune Okamoto, Aitaro Takimoto, Akihiro Yasui, Youichi Nakagawa, Daiki Kato, Yaohui Guo, Takahisa Tainaka

    Journal of pediatric surgery   Vol. 58 ( 9 ) page： 1754 - 1761   2023.9

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    BACKGROUND: Congenital chylothorax (CCT) and postoperative chylothorax (POCT) are rare and difficult to treat. We report our treatment strategy and outcomes for chylothorax, including thoracoscopic surgery with indocyanine-green (ICG) near-infrared fluorescence lymphangiography. METHODS: A retrospective review of patients with CCT and POCT from 2014 to 2021 was performed. After definitive diagnosis, conservative treatments with octreotide, followed by intravenous steroids as needed, were performed. Patients who were refractory to conservative treatment were transferred to surgical treatment, consisting of thoracoscopic lymphatic leak ligations using ICG intraoperative lymphangiography. The effectiveness of conservative and surgical treatment was then examined. RESULTS: We included 19 cases of CCT and 31 cases of POCT. The 31 POCT patients included 23 of 84 postoperative patients with congenital diaphragmatic hernia (CDH), 7 of 54 postoperative patients with esophageal atresia (EA), and 1 of 3 postoperative patients with lymphatic malformation. The efficacy of conservative treatment was 12/19 for CCT, 22/23 for CDH, and 4/7 for EA. Surgical intervention was performed in 10 patients, and the rate of resolution of chylothorax within 3 weeks after surgery was 90%. CONCLUSION: Thoracoscopic lymphatic leak ligations with intraoperative ICG lymphangiography are feasible and useful in patients with chylothorax refractory to conservative treatment. LEVEL OF EVIDENCE: Level IV.

    DOI： 10.1016/j.jpedsurg.2022.11.018

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  11. 特集 急性虫垂炎:診断,治療,研究 複雑性虫垂炎の緊急手術

    田井中 貴久, 城田 千代栄, 住田 亙, 横田 一樹, 牧田 智, 岡本 眞宗, 小梛 地洋, 長島 俊介, 檜 顕成, 内田 広夫

    小児外科   Vol. 55 ( 7 ) page： 751 - 754   2023.7

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    Publisher：東京医学社  

    DOI： 10.24479/ps.0000000514

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  12. Case report: Laparoscopic gastrojejunostomy for duodenal atresia with situs inversus and preduodenal portal vein: a report of two cases

    Nakagawa, Y; Sumida, W; Makita, S; Uchida, H; Hinoki, A; Shirota, C; Tainaka, T; Yokota, K; Amano, H; Yasui, A; Takimoto, A; Kato, D; Maeda, T; Gohda, Y

    FRONTIERS IN PEDIATRICS   Vol. 11   page： 1220393   2023.6

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    Language：English   Publisher：Frontiers in Pediatrics  

    Congenital duodenal atresia with situs inversus is occasionally accompanied by a preduodenal portal vein (PDPV), which is incidentally diagnosed during surgery. Duodenoduodenostomy is the most common and effective treatment. However, some patients require other anastomoses. Here, we present two cases of laparoscopic gastrojejunostomy for congenital duodenal atresia with situs inversus and PDPV and describe the reason for selecting gastrojejunostomy. The optimal surgical strategy is patient specific and should be determined based on the patient's general and physical condition.

    DOI： 10.3389/fped.2023.1220393

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  13. Case Report: Retropancreatic fascia hernia protruding into the thoracic cavity through a Bochdalek hernia

    Nakagawa, Y; Maeda, T; Uchida, H; Takada, S; Hinoki, A; Shirota, C; Tainaka, T; Sumida, W; Makita, S; Amano, H; Takimoto, A; Gohda, Y

    FRONTIERS IN PEDIATRICS   Vol. 11   page： 1149515   2023.6

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    Retropancreatic fascia hernia is a novel internal hernia originating from the retropancreatic fascial defect, which subsequently expands toward the dorsal aspect of the pancreatic body and migrates into the retroperitoneal space. We encountered a rare case of concomitant retropancreatic fascia and Bochdalek hernias. Here, we describe the imaging characteristics of this hernia type and its surgical strategies.

    DOI： 10.3389/fped.2023.1149515

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  14. Preoperative Contrast Examinations Help Determine the Appropriate Cervical Approach for Congenital Gross Type C Esophageal Atresia: A Report of Two Cases

    Nakagawa, Y; Uchida, H; Shirota, C; Tainaka, T; Sumida, W; Amano, H; Takimoto, A; Ogata, S; Takada, S; Maeda, T; Gohda, Y; Guo, YH; Hinoki, A

    AMERICAN JOURNAL OF CASE REPORTS   Vol. 24   page： e938723   2023.6

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    Language：English   Publisher：American Journal of Case Reports  

    Objective: Congenital defects/diseases Background: Kluth demonstrated that esophageal atresia/tracheoesophageal fistula (EA/TEF) has several anatomical variations and thus requires a preoperative imaging study to determine the surgical strategy. We routinely perform a contrast examination with iodixanol to assess the location of the TEF and the upper end of the esophageal pouch to determine the most appropriate approach. We herein present two cases of type C EA/TEF who successfully underwent radical surgery by a cervical approach based on the information from the contrast examination. Case Reports: Case 1 was a Japanese boy suspected of type C EA/TEF after birth. A contrast examination with iodixanol showed that a TEF was at the second thoracic vertebra (Th2), as was the upper end of the esophageal pouch. Thus, the patient underwent esophago-esophageal anastomosis and TEF ligation using a cervical approach; the postoperative course was uneventful. Case 2 was also a Japanese boy suspected of type C EA/TEF. A contrast examination showed that the TEF was at Th1-2, as was the upper end of the esophageal pouch. Thus, the patient underwent esophago-esophageal anastomosis and TEF ligation using a cervical approach. The patient suffered from congenital tracheal stenosis and required tracheoplasty. However, there were no apparent complications after the surgery. Conclusions: Here, we used the imaging information to adopt the cervical approach in type C EA/TEF cases and concluded that routine preoperative contrast examinations helped assess the TEF location and upper end of the esophageal pouch without significant complications.

    DOI： 10.12659/AJCR.938723

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  15. CLINICAL VALIDATION OF NOVEL URINARY MARKERS FOR NEUROBLASTOMA DIAGNOSIS

    Amano, H; Uchida, H; Harada, K; Narita, A; Kumano, S; Abe, M; Sakairi, M; Shirota, C; Tainaka, T; Sumida, W; Yokota, K; Makita, S; Osawa, T; Taguri, M; Takahashi, Y; Hinoki, A

    PEDIATRIC BLOOD & CANCER   Vol. 70   page： S95 - S95   2023.6

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  16. CLINICAL VALIDATION OF NOVEL URINARY MARKERS FOR NEUROBLASTOMA DIAGNOSIS

    Amano Hizuru, Uchida Hiroo, Harada Kazuharu, Narita Atsushi, Kumano Shun, Abe Mayumi, Sakairi Minoru, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Osawa Tsuyoshi, Taguri Masataka, Takahashi Yoshiyuki, Hinoki Akinari

    PEDIATRIC BLOOD & CANCER   Vol. 70   page： S95 - S95   2023.6

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  17. 特集 ロボット支援手術 ロボット支援下胆管切除術

    牧田 智, 内田 広夫, 住田 亙, 檜 顕成, 城田 千代栄, 田井中 貴久, 天野 日出, 滝本 愛太朗, 高田 瞬也, 中川 洋一, 合田 陽祐, 前田 拓也, 郭 垚輝, 劉 佳慧

    小児外科   Vol. 55 ( 5 ) page： 544 - 551   2023.5

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    Publisher：東京医学社  

    DOI： 10.24479/ps.0000000451

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  18. Single-cell RNA sequencing of intestinal immune cells in neonatal necrotizing enterocolitis

    Oshima, K; Hinoki, A; Uchida, H; Tanaka, Y; Okuno, Y; Go, Y; Shirota, C; Tainaka, T; Sumida, W; Yokota, K; Makita, S; Takimoto, A; Kano, Y; Sawa, S

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 39 ( 1 ) page： 179   2023.4

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    Purpose: Necrotizing enterocolitis (NEC) causes fatal intestinal necrosis in neonates, but its etiology is unknown. We analyzed the intestinal immune response to NEC. Methods: Using single-cell RNA sequencing (scRNA-seq), we analyzed the gene expression profiles of intestinal immune cells from four neonates with intestinal perforation (two with NEC and two without NEC). Target mononuclear cells were extracted from the lamina propria of the resected intestines. Results: In all four cases, major immune cells, such as T cells (15.1–47.7%), B cells (3.1–19.0%), monocytes (16.5–31.2%), macrophages (1.6–17.4%), dendritic cells (2.4–12.2%), and natural killer cells (7.5–12.8%), were present in similar proportions to those in the neonatal cord blood. Gene set enrichment analysis showed that the MTOR, TNF-α, and MYC signaling pathways were enriched in T cells of the NEC patients, suggesting upregulated immune responses related to inflammation and cell proliferation. In addition, all four cases exhibited a bias toward cell-mediated inflammation, based on the predominance of T helper 1 cells. Conclusion: Intestinal immunity in NEC subjects exhibited stronger inflammatory responses compared to non-NEC subjects. Further scRNA-seq and cellular analysis may improve our understanding of the pathogenesis of NEC.

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  19. Laparoscopic bile duct plasty for hilar bile duct stenosis (HBDS) in patients with congenital biliary dilatation: Diagnosis of HBDS by preoperative MRCP and laparoscopic strategy to relieve HBDS

    Nakagawa, Y; Uchida, H; Hinoki, A; Shirota, C; Tainaka, T; Sumida, W; Makita, S; Yasui, A; Takimoto, A; Guo, YH

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 30 ( 4 ) page： 473 - 481   2023.4

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    Background/Purpose: Congenital biliary dilatation (CBD) is a disease associated with pancreaticobiliary maljunction. The most frequent postoperative complication is intrahepatic stones, which are caused by hilar bile duct stenosis (HBDS). Methods: We retrospectively reviewed the records of patients who underwent primary surgery for CBD between 2013 and 2021. We evaluated images and videos of HBDS, the laparoscopic technique of releasing the stenosis, and its occurrence rate and compared intraoperative bile duct findings with those of preoperative magnetic resonance cholangiopancreatography (MRCP). Results: There were 87 CBD cases in this study. HBDS occurred in 52% and preoperative MRCP for HBDS showed a 96% sensitivity and 74% specificity in this study. Bile duct plasty was performed in 45% of the cases and videos demonstrated typical methods of laparoscopic bile duct plasty. The mid- to long-term complications were hepatolithiasis in three patients, anastomotic site stricture in three, and postoperative obstruction in two. Conclusions: Our study revealed that preoperative imaging studies are useful for the prediction of HBDS. Our laparoscopic meticulous probing method for finding BDS reveals more intrahepatic BDS through magnification. Therefore, this may reduce the incidence of intrahepatic stones. Preoperative imaging and intraoperative findings can be complemented to plan management that reduces long-term complications.

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  20. Endoscopic injection sclerotherapy with polidocanol for cardiac varices in children and adolescents. International journal

    Shinya Yokoyama, Yoji Ishizu, Takashi Honda, Norihiro Imai, Takanori Ito, Kenta Yamamoto, Akinari Hinoki, Wataru Sumida, Chiyoe Shirota, Takahisa Tainaka, Satoshi Makita, Kazuki Yokota, Hiroo Uchida, Masatoshi Ishigami

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie   Vol. 30 ( 2 ) page： 109 - 112   2023.2

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    BACKGROUND: Like esophageal varices, cardiac varices are often treated with endoscopic variceal ligation (EVL). However, we previously reported that EVL for cardiac varices may be associated with a high risk of rebleeding from the ulcer if the O-ring spontaneously drops off early. The efficacy and safety of para-variceal endoscopic injection sclerotherapy (EIS) with polidocanol for the treatment of cardiac varices in children and adolescents were evaluated. METHODS: Eleven patients under 18 years of age with portal hypertension who underwent para-variceal EIS with polidocanol for cardiac varices with red signs, which were considered to be at high risk of bleeding, were retrospectively reviewed. RESULTS: One session of para-variceal polidocanol-EIS was performed for each of the 11 patients. One patient experienced temporary hypoxia due to aspiration of saliva when the tracheal intubation tube was removed after the procedure but recovered by endotracheal suctioning; there were no other adverse events. In six of the eight cases in which efficacy could be evaluated, eradication of cardiac varices was achieved. CONCLUSION: Para-variceal polidocanol-EIS may be considered instead of EVL for small cardiac varices with red signs in pediatric patients with cardiac varices.

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  21. A new type of retropancreatic fascia hernia in the supramesocolic space preoperatively misdiagnosed as a diaphragmatic hernia: report of two cases. International journal

    Yoichi Nakagawa, Hiroo Uchida, Satoshi Makita, Kazuki Yokota, Akinari Hinoki, Chiyoe Shirota, Takahisa Tainaka, Wataru Sumida, Hizuru Amano, Seiya Ogata, Aitaro Takimoto, Shunya Takada, Takuya Maeda, Yousuke Gohda

    Surgical case reports   Vol. 9 ( 1 ) page： 5 - 5   2023.1

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    BACKGROUND: We encountered two cases of a new type of retroperitoneal hernia. We herein report the unique features of these cases. CASE PRESENTATION: Case 1: A Japanese girl was born at a gestational age of 37 weeks, weighing 2550 g. She underwent laparotomic left diaphragmatic hernia repair for a left Bochdalek hernia at the age of one day. The postoperative course was uneventful; however, chest radiography at the age of 35 days revealed bowel gas in the mediastinum, while computed tomography exhibited intestinal prolapses from the medial side of the mesh into the thoracic cavity. Reoperation was performed at the age of 77 days, showing that the defect hole was not at the diaphragm but in the absence of retropancreatic fascia, which was connected to the posterior mediastinum from the supramesocolic space. The mediastinum space was closed with a suturing spine and artificial mesh, and the defect hole in the pancreatic body was sutured. Case 2: A Japanese boy was born at a gestational age of 40 weeks, weighing 3502 g. He was diagnosed with a left diaphragmatic hernia at birth and underwent laparotomy at the age of two days. Operative findings showed no defect hole in the diaphragm, and no intestine was observed in the abdominal cavity. After close observation of the abdominal cavity, the intestine was found around the pancreatic body, and manual reduction of the intestine was performed. The defect hole existed in the absence of the retropancreatic fascia, which was connected to the extra-pleural space. The defect hole in the pancreatic body was sutured and closed with a non-absorbable thread. CONCLUSIONS: We assumed that our cases were a new type of retroperitoneal hernia, which we named "retropancreatic fascia hernia".

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  22. Laparoscopic restorative proctocolectomy with ileal-J-pouch anal canal anastomosis without diverting ileostomy for total colonic and extensive aganglionosis is safe and feasible with combined Lugol's iodine staining technique and indocyanine green fluorescence angiography

    Nakagawa, Y; Yokota, K; Uchida, H; Hinoki, A; Shirota, C; Tainaka, T; Sumida, W; Makita, S; Amano, H; Takimoto, A; Ogata, S; Takada, S; Maeda, T; Gohda, Y

    FRONTIERS IN PEDIATRICS   Vol. 10   page： 1090336   2023.1

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    Background: We present the surgical technique and outcomes of reduced-port laparoscopic restorative proctocolectomy with ileal-J-pouch anal canal anastomosis (IPACA) without diverting ileostomy for total colonic and extensive aganglionosis (TCA+). Methods: We retrospectively reviewed TCA+ cases between 2014 and 2022. Preoperative ileostomy was performed when transanal bowel irrigation was ineffective. Radical surgery for TCA+ was performed at approximately 6 kg. The surgery was performed using laparoscopy through a multi-channel trocar with or without an additional 3-mm trocar and IPACA reconstruction with indocyanine green fluorescence angiography (ICG) to assess anastomotic perfusion and Lugol's iodine staining to visualize the surgical anal canal. Results: Ten patients with TCA+ were included. Ileostomy was performed in seven cases. The median operation time and blood loss were 274.5 min and 20 ml, respectively. No significant postoperative complications were found. All patients experienced frequent liquid stools and perianal excoriation in the early postoperative period, requiring anti-flatulence or codeine. The median follow-up period was 3.5 years. Three patients required irrigation management 1 year postoperatively, and the others defecated a median of 3.5 times per day. The median Kelly's clinical score was 5 in 5 patients aged >4 years. Conclusion: Reduced-port surgery, combined with Lugol's iodine staining and ICG, was safe, feasible, and had cosmetically and clinically acceptable mid-term outcomes.

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  23. The presence of high-risk varices after sclerotherapy in biliary atresia. International journal

    Shinya Yokoyama, Yoji Ishizu, Takashi Honda, Norihiro Imai, Takanori Ito, Kenta Yamamoto, Chiyoe Shirota, Takahisa Tainaka, Wataru Sumida, Satoshi Makita, Aitaro Takimoto, Yoichi Nakagawa, Shunya Takada, Masatoshi Ishigami, Hiroo Uchida, Hiroki Kawashima

    Pediatrics international : official journal of the Japan Pediatric Society   Vol. 65 ( 1 ) page： e15454   2023.1

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    BACKGROUND: Esophagogastric varices (EGVs) may develop as a result of portal hypertension in children with biliary atresia (BA). Although endoscopic injection sclerotherapy (EIS) with ethanolamine oleate (EO) is reported useful for children, risk factors associated with the presence of high-risk EGVs after treatment remain unknown. METHODS: The subjects were BA patients under 15 years of age who underwent EO-EIS. We retrospectively reviewed a total of 28 treatment sessions of EGVs with red signs and those larger than F2, which were considered to be at high risk of bleeding. Survival analysis was performed for the presence of high-risk EGVs at the time of follow-up endoscopy as the occurrence of an event. RESULTS: Univariate analysis showed a significantly increased risk of the presence of high-risk EGVs post-EO-EIS in patients with increased liver stiffness (LS) and Mac-2 binding protein glycan isomer (M2BPGi), with hazard ratios of 1.48 and 1.15, respectively. The median presence-free period was significantly shorter in the LS ≥ 2.8 m/sec patients than in those with LS < 2.8 m/sec (189 vs. 266 days). Similarly, the median presence-free period was significantly shorter in patients with M2BPGi ≥ 4.0 than in those with M2BPGi < 4.0 (182 vs. 203 days). The results of multivariate analysis revealed that the risk of the presence of high-risk EGVs was significantly higher only in the high-LS group, with a hazard ratio of 2.76. CONCLUSIONS: Increased LS is associated with risk of the presence of high-risk EGVs following EO-EIS in children with BA. (246 words).

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  24. 先天性十二指腸閉鎖症・狭窄症に合併した膵・胆管合流異常の4例

    牧田 智, 内田 広夫, 檜顕 成, 寺脇 幹, 城田 千代栄, 田井中 貴久, 住田 亙, 横田 一樹, 天野 日出, 滝本 愛太朗, 安井 昭洋, 中川 洋一, 加藤 大幾, 合田 陽祐, 前田 拓也, 郭 垚輝, 劉 佳慧

    日本膵・胆管合流異常研究会プロシーディングス   Vol. 46 ( 0 ) page： 52 - 53   2023

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    DOI： 10.34410/jspbm.46.0_52

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  25. Biochemical markers to predict the development of gastrointestinal bleeding and esophageal varices after portoenterostomy in biliary atresia

    Sumida Wataru, Tainaka Takahisa, Shirota Chiyoe, Yokota Kazuki, Makita Satoshi, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Takada Shunya, Nakagawa Yoichi, Kato Daiki, Yokoyama Shinya, Ishizu Yoji, Amano Hizuru, Guo Yaohui, Hinoki Akinari, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 38 ( 12 ) page： 1799 - 1805   2022.12

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  26. Adding a spur valve to laparoscopic portoenterostomy for patients with biliary atresia can achieve a high jaundice clearance rate and lower the number of episodes of cholangitis

    Yasui Akihiro, Hinoki Akinari, Amano Hizuru, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Okamoto Masamune, Takimoto Aitaro, Nakagawa Yoichi, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 38 ( 12 ) page： 1881 - 1885   2022.12

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  27. Circumumbilical incision for neonatal abdominal surgery: additional skin incision when there is difficulty in manipulating the intestine.

    Yoichi Nakagawa, Akinari Hinoki, Hizuru Amano, Hiroo Uchida, Chiyoe Shirota, Takahisa Tainaka, Wataru Sumida, Kazuki Yokota, Satoshi Makita, Masamune Okamoto, Aitaro Takimoto, Akihiro Yasui, Shunya Takada, Daiki Kato

    Nagoya journal of medical science   Vol. 84 ( 4 ) page： 716 - 722   2022.11

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    This study aimed to evaluate the safety and effectiveness of circumumbilical incision (CUI) for neonates requiring intestinal anastomosis. Seventy neonates requiring intestinal anastomosis at our institution between 2003 and 2020 were included in this retrospective case-control study. Patients were classified into the CUI (25 patients: 36%) and transverse incision (TI) groups (45 patients: 64%). Postoperative complications and surgical outcomes were compared between the two groups. Intestinal perforation at the non-anastomotic site occurred significantly more often in the CUI group than in the TI group (3 patients: 12%, and 0 patients: 0%, respectively (p = 0.042)). There were no between-group differences regarding anastomotic leakages, anastomotic strictures, time to enteral feeding, operative time, and blood loss. Neonatal intestinal surgery employing CUI might be associated with increased intestinal perforation at the non-anastomotic site. Hesitating to enlarge the skin incision to maintain favorable cosmetic outcomes might cause severe injury to the delicate neonatal intestine during the surgical procedure owing to the restricted surgical field. When performing CUI, we suggest that the skin incision should be extended without hesitation whenever there is difficulty in manipulating the intestine.

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  28. Laparoscopic definitive surgery for congenital biliary dilatation with aggressive hilar bile ductoplasty and complete resection of the intrapancreatic bile duct in pediatric patients is safe and effective, comparable to open surgery

    Tainaka Takahisa, Shirota Chiyoe, Hinoki Akinari, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Amano Hizuru, Tanaka Yujiro, Uchida Hiroo

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   Vol. 36 ( 10 ) page： 7352 - 7359   2022.10

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  29. Evaluation of minimally invasive surgical skills training: comparing a neonatal esophageal atresia/tracheoesophageal fistula model with a dry box.

    Deie K, Nakagawa Y, Uchida H, Hinoki A, Shirota C, Tainaka T, Sumida W, Yokota K, Makita S, Fujiogi M, Okamoto M, Takimoto A, Yasui A, Takada S, Maeda T

    Surgical endoscopy   Vol. 36 ( 8 ) page： 6035 - 6048   2022.8

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  30. Evaluation of minimally invasive surgical skills training: comparing a neonatal esophageal atresia/tracheoesophageal fistula model with a dry box

    Deie Kyoichi, Nakagawa Yoichi, Uchida Hiroo, Hinoki Akinari, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Fujiogi Michimasa, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Takada Shunya, Maeda Takuya

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   Vol. 36 ( 8 ) page： 6035 - 6048   2022.8

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  31. Evaluation of minimally invasive surgical skills training: comparing a neonatal esophageal atresia/tracheoesophageal fistula model with a dry box

    Deie Kyoichi, Nakagawa Yoichi, Uchida Hiroo, Hinoki Akinari, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Fujiogi Michimasa, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Takada Shunya, Maeda Takuya

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   Vol. 36 ( 8 ) page： 6035 - 6048   2022.8

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  32. Risk factors for unplanned removal of central venous catheters in hospitalized children with hematological and oncological disorders

    Miyagishima Moe, Hamada Motoharu, Hirayama Yuji, Muramatsu Hideki, Tainaka Takahisa, Shirota Chiyoe, Hinoki Akinari, Imaizumi Takahiro, Nakatochi Masahiro, Kamei Michi, Nishikawa Eri, Kawashima Nozomu, Narita Atsushi, Nishio Nobuhiro, Kojima Seiji, Takahashi Yoshiyuki

    INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 116 ( 2 ) page： 288 - 294   2022.8

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  33. Thoracoscopic posterior tracheopexy during primary esophageal atresia repair ameliorate tracheomalacia in neonates: a single-center retrospective comparative cohort study

    Yasui Akihiro, Hinoki Akinari, Amano Hizuru, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Okamoto Masamune, Takimoto Aitaro, Nakagawa Yoichi, Uchida Hiroo

    BMC SURGERY   Vol. 22 ( 1 ) page： 285   2022.7

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  34. A patient with very early onset FH-deficient renal cell carcinoma diagnosed at age seven

    Taniguchi Rieko, Muramatsu Hideki, Okuno Yusuke, Yoshida Taro, Wakamatsu Manabu, Hamada Motoharu, Shirota Chiyoe, Sumida Wataru, Hinoki Akinari, Tainaka Takahisa, Gotoh Yoshimitsu, Tsuzuki Toyonori, Tanaka Yukichi, Kojima Seiji, Uchida Hiroo, Takahashi Yoshiyuki

    FAMILIAL CANCER   Vol. 21 ( 3 ) page： 337 - 341   2022.7

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  35. Patients with gastric volvulus recurrence have high incidence of wandering spleen requiring laparoscopic gastropexy and splenopexy

    Nakagawa Yoichi, Uchida Hiroo, Amano Hizuru, Hinoki Akinari, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Takada Shunya, Kato Daiki

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 38 ( 6 ) page： 875 - 881   2022.6

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  36. Single-incision laparoscopic percutaneous extraperitoneal closure (SILPEC) for inguinal hernia with prolapsed ovary

    Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Amano Hizuru, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Nakagawa Yoichi, Hinoki Akinari, Uchida Hiroo

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   Vol. 36 ( 6 ) page： 4328 - 4332   2022.6

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  37. Serum matrix metalloproteinase-7 in biliary atresia: A Japanese multicenter study

    Sakaguchi Hirotaka, Konishi Ken-ichiro, Yasuda Ryosuke, Sasaki Hideyuki, Yoshimaru Koichiro, Tainaka Takahisa, Fukahori Suguru, Sanada Yukihiro, Iwama Itaru, Shoji Hiromichi, Kinoshita Masahiro, Matsuura Toshiharu, Fujishiro Jun, Uchida Hiroo, Nio Masaki, Yamashita Yushiro, Mizuochi Tatsuki

    HEPATOLOGY RESEARCH   Vol. 52 ( 5 ) page： 479 - 487   2022.5

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  38. Utility of endoscopic retrograde cholangiopancreatography in management of pediatric pancreaticobiliary disease

    Makita Satoshi, Amano Hizuru, Kawashima Hiroki, Hinoki Akinari, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Nakagawa Yoichi, Uchida Hiroo

    BMC PEDIATRICS   Vol. 22 ( 1 ) page： 134   2022.3

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  39. Laparoscopic Kasai portoenterostomy can be a standard surgical procedure for treatment of biliary atresia

    Shirota Chiyoe, Hinoki Akinari, Tainaka Takahisa, Sumida Wataru, Kinoshita Fumie, Yokota Kazuki, Makita Satoshi, Amano Hizuru, Nakagawa Yoichi, Uchida Hiroo

    WORLD JOURNAL OF GASTROINTESTINAL SURGERY   Vol. 14 ( 1 ) page： 56 - 63   2022.1

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  40. Laparoscopic definitive surgery for choledochal cyst is performed safely and effectively in infants

    Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Amano Hizuru, Okamoto Masamune, Takimoto Aitaro, Kano Yoko, Yasui Akihiro, Nakagawa Yoichi, Hinoki Akinari, Uchida Hiroo

    JOURNAL OF MINIMAL ACCESS SURGERY   Vol. 18 ( 3 ) page： 372 - 377   2022

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  41. An imaging study on tracheomalacia in infants with esophageal atresia: the degree of tracheal compression by the brachiocephalic artery is a good indicator for therapeutic intervention

    Sumida Wataru, Tainaka Takahisa, Shirota Chiyoe, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Yasui Akihiro, Okamoto Masamune, Nakagawa Yoichi, Hinoki Akinari, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 12 ) page： 1719 - 1724   2021.12

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  42. Clinical characteristics and outcomes of the right congenital diaphragmatic hernia compared to the left: a 10-year single-center experience

    Okamoto Masamune, Amano Hizuru, Uchida Hiroo, Hinoki Akinari, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Yasui Akihiro, Nakagawa Yoichi

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 12 ) page： 1675 - 1681   2021.12

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  43. Urinary N-1,N-12-diacetylspermine as a biomarker for pediatric cancer: a case-control study

    Yokota Kazuki, Hinoki Akinari, Hiramatsu Kyoko, Amano Hizuru, Kawamura Machiko, Kuwatsuka Yachiyo, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Okamoto Masamune, Takimoto Aitaro, Yasui Akihiro, Nakagawa Yoichi, Uchida Hiroo, Kawakita Masao

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 12 ) page： 1659 - 1665   2021.12

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  44. Long-term outcomes of the partial splenectomy for hypersplenism after portoenterostomy of patients with biliary atresia

    Tainaka Takahisa, Hinoki Akinari, Tanaka Yujiro, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Oshima Kazuo, Amano Hizuru, Takimoto Aitaro, Kano Yoko, Uchida Hiroo

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 4 ) page： 765 - 771   2021.11

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  45. Factors associated with bleeding after endoscopic variceal ligation in children

    Yokoyama Shinya, Ishizu Yoji, Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ito Takanori, Hinoki Akinari, Sumida Wataru, Shirota Chiyoe, Tainaka Takahisa, Makita Satoshi, Yokota Kazuki, Uchida Hiroo, Fujishiro Mitsuhiro

    PEDIATRICS INTERNATIONAL   Vol. 63 ( 10 ) page： 1223 - 1229   2021.10

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  46. SERUM MATRIX METALLOPROTEINASE-7 IN JAPANESE INFANTS WITH BILIARY ATRESIA

    Mizuochi Tatsuki, Sakaguchi Hirotaka, Konishi Ken-Ichiro, Yasuda Ryosuke, Kinoshita Masahiro, Fukahori Suguru, Shoji Hiromichi, Yoshimaru Koichiro, Matsuura Toshiharu, Sanada Yukihiro, Tainaka Takahisa, Uchida Hiroo, Sasaki Hideyuki, Iwama Itaru, Fujishiro Jun, Nio Masaki

    HEPATOLOGY   Vol. 74   page： 1178A - 1178A   2021.10

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  47. SERUM MATRIX METALLOPROTEINASE-7 IN JAPANESE INFANTS WITH BILIARY ATRESIA

    Mizuochi Tatsuki, Sakaguchi Hirotaka, Konishi Ken-Ichiro, Yasuda Ryosuke, Kinoshita Masahiro, Fukahori Suguru, Shoji Hiromichi, Yoshimaru Koichiro, Matsuura Toshiharu, Sanada Yukihiro, Tainaka Takahisa, Uchida Hiroo, Sasaki Hideyuki, Iwama Itaru, Fujishiro Jun, Nio Masaki

    HEPATOLOGY   Vol. 74   page： 1178A - 1178A   2021.10

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  48. Late postoperative complications of congenital biliary dilatation in pediatric patients: a single-center experience of managing complications for over 20 years

    Amano Hizuru, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Tanaka Yujiro, Hinoki Akinari, Kawashima Hiroki, Uchida Hiroo

    SURGERY TODAY   Vol. 51 ( 9 ) page： 1488 - 1495   2021.9

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  49. Development of a novel diagnostic system for bile duct cancer using urinary metabolites.

    Amano Hizuru, Hinoki Akinari, Uchida Hiroo, Yokota Kazuki, Ishigaki Takashi, Sakairi Minoru, Abe Mayumi, Terui Yasushi, Oda Hirohisa, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Okamoto Masamune, Yasui Akihiro, Nakagawa Yoichi

    CANCER RESEARCH   Vol. 81 ( 13 )   2021.7

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  50. Development of a novel diagnostic system for bile duct cancer using urinary metabolites.

    Amano Hizuru, Hinoki Akinari, Uchida Hiroo, Yokota Kazuki, Ishigaki Takashi, Sakairi Minoru, Abe Mayumi, Terui Yasushi, Oda Hirohisa, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Okamoto Masamune, Yasui Akihiro, Nakagawa Yoichi

    CANCER RESEARCH   Vol. 81 ( 13 )   2021.7

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  51. NOVEL BIOMARKER DISCOVERY FOR CHILDHOOD RHABDOMYOSARCOMA USING URINARY METABOLITES

    Amano Hizuru, Hinoki Akinari, Uchida Hiroo, Yokota Kazuki, Ishigaki Takashi, Sakairi Minoru, Abe Mayumi, Terui Yasushi, Oda Hirohisa, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Kano Yoko, Okamoto Masamune, Yasui Akihiro, Nakagawa Yoichi

    PEDIATRIC BLOOD & CANCER   Vol. 68   page： S46 - S46   2021.6

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  52. Postoperative intestinal obstruction in patients with biliary atresia impedes biliary excretion and results in subsequent liver transplantation (vol 37, pg 229, 2021)

    Takimoto Aitaro, Sumida Wataru, Amano Hizuru, Shirota Chiyoe, Tainaka Takahisa, Yokota Kazuki, Makita Satoshi, Yasui Akihiro, Kanou Yoko, Hinoki Akinari, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 6 ) page： 835 - 835   2021.6

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  53. NOVEL BIOMARKER DISCOVERY FOR CHILDHOOD RHABDOMYOSARCOMA USING URINARY METABOLITES

    Amano Hizuru, Hinoki Akinari, Uchida Hiroo, Yokota Kazuki, Ishigaki Takashi, Sakairi Minoru, Abe Mayumi, Terui Yasushi, Oda Hirohisa, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Kano Yoko, Okamoto Masamune, Yasui Akihiro, Nakagawa Yoichi

    PEDIATRIC BLOOD & CANCER   Vol. 68   page： S46 - S46   2021.6

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  54. Double-balloon endoscopic retrograde cholangiography can make a reliable diagnosis and good prognosis for postoperative complications of congenital biliary dilatation

    Shirota Chiyoe, Kawashima Hiroki, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Amano Hizuru, Takimoto Aitaro, Hinoki Akinari, Uchida Hiroo

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page： 11052   2021.5

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  55. Urinary biomarkers for monitoring treatment response in neuroblastoma patients.

    Amano Hizuru, Hinoki Akinari, Uchida Hiroo, Yokota Kazuki, Ishigaki Takashi, Sakairi Minoru, Abe Mayumi, Takahashi Yoshiyuki, Narita Atsushi, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Kano Yoko, Yasui Akihiro, Okamoto Masamune, Nakagawa Yoichi

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 39 ( 15 )   2021.5

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  56. A Japanese prospective multicenter study of urinary oxysterols in biliary atresia

    Konishi Ken-ichiro, Mizuochi Tatsuki, Takei Hajime, Yasuda Ryosuke, Sakaguchi Hirotaka, Ishihara Jun, Takaki Yugo, Kinoshita Masahiro, Hashizume Naoki, Fukahori Suguru, Shoji Hiromichi, Miyano Go, Yoshimaru Koichiro, Matsuura Toshiharu, Sanada Yukihiro, Tainaka Takahisa, Uchida Hiroo, Kubo Yumiko, Tanaka Hiromu, Sasaki Hideyuki, Murai Tsuyoshi, Fujishiro Jun, Yamashita Yushiro, Nio Masaki, Nittono Hiroshi, Kimura Akihiko

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page： 4986   2021.3

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  57. Identification of novel neuroblastoma biomarkers in urine samples

    Yokota Kazuki, Uchida Hiroo, Sakairi Minoru, Abe Mayumi, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Oshima Kazuo, Makita Satoshi, Amano Hizuru, Hinoki Akinari

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page： 4055   2021.2

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  58. Postoperative intestinal obstruction in patients with biliary atresia impedes biliary excretion and results in subsequent liver transplantation

    Takimoto Aitaro, Sumida Wataru, Amano Hizuru, Shirota Chiyoe, Tainaka Takahisa, Yokota Kazuki, Makita Satoshi, Yasui Akihiro, Kanou Yoko, Hinoki Akinari, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 2 ) page： 229 - 234   2021.2

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  59. Thoracoscopic surgery for congenital lung cysts: an attempt to limit pulmonary resection in cases of lesions involving multiple lobes

    Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Takimoto Aitaro, Amano Hizuru, Hinoki Akinari, Ono Yasuyuki, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 2 ) page： 213 - 221   2021.2

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  60. Risk factors and outcomes of bile leak after laparoscopic surgery for congenital biliary dilatation

    Tanaka Yujiro, Tainaka Takahisa, Hinoki Akinari, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Oshima Kazuo, Makita Satoshi, Amano Hizuru, Takimoto Aitaro, Kano Yoko, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 37 ( 2 ) page： 235 - 240   2021.2

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  61. A novel Lugol's iodine staining technique to visualize the upper margin of the surgical anal canal intraoperatively for Hirschsprung disease: a case series

    Yokota Kazuki, Amano Hizuru, Kudo Toyoki, Yamamura Takeshi, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Makita Satoshi, Takimoto Aitaro, Nakamura Masanao, Fujishiro Mitsuhiro, Hinoki Akinari, Uchida Hiroo

    BMC SURGERY   Vol. 20 ( 1 ) page： 317   2020.12

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  62. URINARY OXYSTEROLS IN BILIARY ATRESIA: A PROSPECTIVE MULTICENTER STUDY IN JAPAN

    Konishi Ken-ichiro, Mizuochi Tatsuki, Takei Hajime, Yesuda Ryosuke, Sakaguchi Hirotaka, Ishihara Jun, Takaki Yugo, Kinoshita Masahiro, Hashizume Naoki, Fukahori Suguru, Shoji Hiromichi, Miyano Go, Yoshimaru Koichiro, Matsuura Toshiharu, Sanada Yukihiro, Tainaka Takahisa, Uchida Hiroo, Kubo Yumiko, Tanaka Hiromu, Sasaki Hideyuki, Murai Tsuyoshi, Fujishiro Jun, Yamashita Yushiro, Nio Masaki, Nittono Hiroshi, Kimura Akihiko

    HEPATOLOGY   Vol. 72   page： 224A - 225A   2020.11

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  63. URINARY OXYSTEROLS IN BILIARY ATRESIA: A PROSPECTIVE MULTICENTER STUDY IN JAPAN

    Konishi Ken-ichiro, Mizuochi Tatsuki, Takei Hajime, Yesuda Ryosuke, Sakaguchi Hirotaka, Ishihara Jun, Takaki Yugo, Kinoshita Masahiro, Hashizume Naoki, Fukahori Suguru, Shoji Hiromichi, Miyano Go, Yoshimaru Koichiro, Matsuura Toshiharu, Sanada Yukihiro, Tainaka Takahisa, Uchida Hiroo, Kubo Yumiko, Tanaka Hiromu, Sasaki Hideyuki, Murai Tsuyoshi, Fujishiro Jun, Yamashita Yushiro, Nio Masaki, Nittono Hiroshi, Kimura Akihiko

    HEPATOLOGY   Vol. 72   page： 224A - 225A   2020.11

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  64. Laparoscopic Kasai portoenterostomy is advantageous over open Kasai portoenterostomy in subsequent liver transplantation

    Shirota Chiyoe, Murase Naruhiko, Tanaka Yujiro, Ogura Yasuhiro, Nakatochi Masahiro, Kamei Hideya, Kurata Nobuhiko, Hinoki Akinari, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Oshima Kazuo, Uchida Hiroo

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   Vol. 34 ( 8 ) page： 3375 - 3381   2020.8

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  65. Safe diagnostic management of malignant mediastinal tumors in the presence of respiratory distress: a 10-year experience

    Tomoko Tanaka, Hizuru Amano, Yujiro Tanaka, Yoshiyuki Takahashi, Tatsuro Tajiri, Takahisa Tainaka, Chiyoe Shirota, Wataru Sumida, Kazuki Yokota, Satoshi Makita, Yukiko Tani, Akinari Hinoki, Hiroo Uchida

    BMC Pediatrics   Vol. 20 ( 1 ) page： 292   2020.6

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    Abstract

    Background

    The fundamental treatment for patients with pediatric malignant mediastinal tumors is chemotherapy. Therefore, accurate diagnosis is essential for selecting the appropriate chemotherapeutic regimen. However, malignant mediastinal tumors occasionally cause respiratory distress, and biopsies under general anesthesia are dangerous for such patients as invasive mechanical ventilation can aggravate airway obstruction caused by mass effect. In this study, we reviewed our 10-year diagnostic experience to evaluate the efficacy of our practices and confirm a safe diagnostic protocol for future patients.

    Methods

    We retrospectively reviewed medical records of children with malignant mediastinal tumors diagnosed at Nagoya University Hospital from 2007 to 2018 who demonstrated respiratory distress. Respiratory distress included dyspnea, massive pleural effusion, wheezing, and hypoxemia owing to tumors. Data on sex, age at onset, primary symptoms, location of tumor, management strategy (especially the method of diagnosis and definitive diagnosis), clinical course, prognosis during the acute phase (within 3 months from the onset of respiratory symptoms), and long-term outcome were collected.

    Results

    Twelve pediatric patients met the review criteria. There were seven anterior mediastinal tumors and five posterior mediastinal tumors. All anterior mediastinal tumors were diagnosed via bone marrow smear, thoracentesis, or core needle biopsy while maintaining spontaneous breathing. Regarding posterior tumors, two patients were diagnosed via a core needle biopsy and lymph node excisional biopsy under spontaneous breathing. Two cases were initially diagnosed solely using tumor markers. One patient with severe tracheal compression underwent tumor resection with extracorporeal membrane oxygenation stand-by. No patient died of diagnostic procedure-related complications.

    Conclusions

    In 11 of the 12 cases reviewed, safe and accurate tumor diagnosis was accomplished without general anesthesia. A diagnostic strategy without general anesthesia considering the tumor location proved to be useful.

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    Other Link： https://link.springer.com/article/10.1186/s12887-020-02183-w/fulltext.html

  66. Laparoscopically Assisted Anorectoplasty for Intermediate-Type Imperforate Anus: Comparison of Surgical Outcomes with the Sacroperineal Approach

    Ishimaru Tetsuya, Kawashima Hiroshi, Tainaka Takahisa, Suzuki Keisuke, Takami Shohei, Kakihara Tomo, Katoh Reiko, Aoyama Tomohiro, Uchida Hiroo, Iwanaka Tadashi

    JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES   Vol. 30 ( 3 ) page： 350 - 354   2020.3

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  67. Intestinal flow after anastomotic operations in neonates

    Ito Yasumasa, Asato Koichiro, Cho Inhyeok, Sakai Yasuhiko, Iwano Koji, Tainaka Takahisa, Uchida Hiroo

    COMPUTERS IN BIOLOGY AND MEDICINE   Vol. 118   page： 103471   2020.3

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  68. Identification and Validation of Novel Non-invasive Biomarkers in Patient Urine Samples for Diagnosis of New and Recurrent Neuroblastoma

    Yokota Kazuki, Uchida Hiroo, Hinoki Akinari, Sakairi Minoru, Abe Mayumi, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Oshima Kazuo, Makita Satoshi, Takimoto Aitaro, Kano Yoko, Inada Kosuke

    PEDIATRIC BLOOD & CANCER   Vol. 66   page： S106 - S106   2019.12

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  69. Identification and Validation of Novel Non-invasive Biomarkers in Patient Urine Samples for Diagnosis of New and Recurrent Neuroblastoma

    Yokota Kazuki, Uchida Hiroo, Hinoki Akinari, Sakairi Minoru, Abe Mayumi, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Oshima Kazuo, Makita Satoshi, Takimoto Aitaro, Kano Yoko, Inada Kosuke

    PEDIATRIC BLOOD & CANCER   Vol. 66   page： S106 - S106   2019.12

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  70. Biodegradable Surgical Staple Composed of Magnesium Alloy

    Amano Hizuru, Hanada Kotaro, Hinoki Akinari, Tainaka Takahisa, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Murase Naruhiko, Oshima Kazuo, Chiba Kosuke, Tanaka Yujiro, Uchida Hiroo

    SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page： 14671   2019.10

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  71. Efficacy of and prognosis after steroid pulse therapy in patients with poor reduction of jaundice after laparoscopic Kasai portoenterostomy

    Tanaka Yujiro, Shirota Chiyoe, Tainaka Takahisa, Sumida Wataru, Oshima Kazuo, Makita Satoshi, Tanaka Tomoko, Tani Yukiko, Chiba Kosuke, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 35 ( 10 ) page： 1059 - 1063   2019.10

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  72. Spleen stiffness by 2-D shear wave elastography is the most accurate predictor of high-risk esophagogastric varices in children with biliary atresia

    Yokoyama Shinya, Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ito Takanori, Hirooka Yoshiki, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Chiba Kosuke, Uchida Hiroo, Fujishiro Mitsuhiro

    HEPATOLOGY RESEARCH   Vol. 49 ( 10 ) page： 1162 - 1168   2019.10

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  73. Therapeutic strategy for thoracoscopic repair of esophageal atresia and its outcome

    Shirota Chiyoe, Tanaka Yujiro, Tainaka Takahisa, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Oshima Kazuo, Tanaka Tomoko, Tani Yukiko, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 35 ( 10 ) page： 1071 - 1076   2019.10

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  74. Nuss procedure for patients with pectus excavatum with a history of intrathoracic surgery

    Takanari Keisuke, Toriyama Kazuhiro, Kambe Miki, Nakamura Yutaka, Uchibori Takafumi, Ebisawa Katsumi, Shirota Chiyoe, Tainaka Takahisa, Uchida Hiroo, Kamei Yuzuru

    JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY   Vol. 72 ( 6 ) page： 1025 - 1029   2019.6

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  75. A Novel Laparoscopic Surgery Model with a Device to Expand the Abdominal Working Space in Rats: The Influence of Pneumoperitoneum and Skin Incision Length on Postoperative Inflammatory Cytokines

    Murase Naruhiko, Tainaka Takahisa, Uchida Hiroo, Hinoki Akinari, Shirota Chiyoe, Yokota Kazuki, Oshima Kazuo, Shirotsuki Ryo, Chiba Kosuke, Tanaka Yujiro

    JOURNAL OF INVESTIGATIVE SURGERY   Vol. 32 ( 1 ) page： 55 - 60   2019.1

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  76. Air test as a simple method of screening for Hirschsprung's disease

    Sumida W., Uchida H., Ono Y., Tanaka Y., Tainaka T., Shirota C., Yokota K., Oshima K., Chiba K.

    CLINICAL RADIOLOGY   Vol. 73 ( 12 ) page： 1041 - 1045   2018.12

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  77. Indications for total esophagogastric dissociation in children with gastroesophageal reflux disease

    Tanaka Yujiro, Tainaka Takahisa, Uchida Hiroo

    SURGERY TODAY   Vol. 48 ( 11 ) page： 971 - 977   2018.11

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  78. Long-term outcomes and complications after laparoscopic-assisted anorectoplasty vs. posterior sagittal anorectoplasty for high- and intermediate-type anorectal malformation

    Tainaka Takahisa, Uchida Hiroo, Tanaka Yujiro, Hinoki Akinari, Shirota Chiyoe, Sumida Wataru, Yokota Kazuki, Makita Satoshi, Oshima Kazuo, Chiba Kosuke, Ishimaru Tetsuya, Kawashima Hiroshi

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 34 ( 10 ) page： 1111 - 1115   2018.10

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    DOI： 10.1007/s00383-018-4323-4

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  79. Introduction of resection of intrahepatic bile duct stenosis-causing membrane or septum into laparoscopic choledochal cyst excision

    Tanaka Yujiro, Tainaka Takahisa, Sumida Wataru, Hinoki Akinari, Shirota Chiyoe, Murase Naruhiko, Oshima Kazuo, Shirotsuki Ryo, Chiba Kosuke, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 34 ( 10 ) page： 1087 - 1092   2018.10

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  80. Investigation of the feasibility and safety of single-stage anorectoplasty in neonates with anovestibular fistula

    Shirota Chiyoe, Suzuki Keisuke, Uchida Hiroo, Kawashima Hiroshi, Hinoki Akinari, Tainaka Takahisa, Sumida Wataru, Murase Naruhiko, Oshima Kazuo, Chiba Kosuke, Makita Satoshi, Tanaka Yujiro

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 34 ( 10 ) page： 1117 - 1120   2018.10

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  81. Oral administration of eicosapentaenoic acid suppresses liver fibrosis in postoperative patients with biliary atresia

    Sumida Wataru, Uchida Hiroo, Tainaka Takahisa, Shirota Chiyoe, Hinoki Akinari, Kato Takazumi, Yokota Kazuki, Oshima Kazuo, Shirotuki Ryo, Chiba Kosuke, Tanaka Yujiro

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 34 ( 10 ) page： 1059 - 1063   2018.10

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  82. The impact of body weight on stapled anastomosis in pediatric patients

    Amano Hizuru, Tanaka Yujiro, Tainaka Takahisa, Hinoki Akinari, Kawashima Hiroshi, Kakihara Tomo, Morita Kaori, Uchida Hiroo

    JOURNAL OF PEDIATRIC SURGERY   Vol. 53 ( 10 ) page： 2036 - 2040   2018.10

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  83. Single-stage laparoscopic transanal pull-through modified Swenson procedure without leaving a muscular cuff for short- and long-type Hirschsprung disease: a comparative study

    Yokota Kazuki, Uchida Hiroo, Tainaka Takahisa, Tanaka Yujiro, Shirota Chiyoe, Hinoki Akinari, Kato Takazumi, Sumida Wataru, Oshima Kazuo, Chiba Kosuke, Ishimaru Tetsuya, Kawashima Hiroshi

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 34 ( 10 ) page： 1105 - 1110   2018.10

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  84. Excellent prognosis of patients with intermediate-risk neuroblastoma and residual tumor postchemotherapy

    Amano Hizuru, Uchida Hiroo, Tanaka Yujiro, Tainaka Takahisa, Mori Makiko, Oguma Eiji, Kishimoto Hiroshi, Kawashima Hiroshi, Arakawa Yuki, Hanada Ryoji, Koh Katsuyoshi

    JOURNAL OF PEDIATRIC SURGERY   Vol. 53 ( 9 ) page： 1761 - 1765   2018.9

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  85. Novel thoracoscopic navigation surgery for neonatal chylothorax using indocyanine-green fluorescent lymphography

    Shirotsuki Ryo, Uchida Hiroo, Tanaka Yujiro, Shirota Chiyoe, Yokota Kazuki, Murase Naruhiko, Hinoki Akinari, Oshima Kazuo, Chiba Kosuke, Sumida Wataru, Hayakawa Masahiro, Tainaka Takahisa

    JOURNAL OF PEDIATRIC SURGERY   Vol. 53 ( 6 ) page： 1246 - 1249   2018.6

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  86. Clinical, Pathologic, and Genetic Features of Neonatal Dubin-Johnson Syndrome: A Multicenter Study in Japan

    Togawa Takao, Mizuochi Tatsuki, Sugiura Tokio, Kusano Hironori, Tanikawa Ken, Sasaki Takato, Ichinose Fumio, Kagimoto Seiichi, Tainaka Takahisa, Uchida Hiroo, Saitoh Shinji

    JOURNAL OF PEDIATRICS   Vol. 196   page： 161 - +   2018.5

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  87. Usefulness of fetal magnetic resonance imaging for postnatal management of congenital lung cysts: prediction of probability for emergency surgery

    Shirota Chiyoe, Tainaka Takahisa, Nakane Toshiki, Tanaka Yujiro, Hinoki Akinari, Sumida Wataru, Murase Naruhiko, Oshima Kazuo, Chiba Kosuke, Shirotsuki Ryo, Uchida Hiroo

    BMC PEDIATRICS   Vol. 18 ( 1 ) page： 105   2018.3

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  88. The efficacy of resection of intrahepatic bile duct stenosis-causing membrane or septum for preventing hepatolithiasis after choledochal cyst excision

    Tanaka Yujiro, Tainaka Takahisa, Sumida Wataru, Shirota Chiyoe, Hinoki Akinari, Murase Naruhiko, Oshima Kazuo, Shirotsuki Ryo, Chiba Kosuke, Uchida Hiroo

    JOURNAL OF PEDIATRIC SURGERY   Vol. 52 ( 12 ) page： 1930 - 1933   2017.12

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  89. Comparison of outcomes of thoracoscopic primary repair of gross type C esophageal atresia performed by qualified and non-qualified surgeons

    Tanaka Yujiro, Tainaka Takahisa, Sumida Wataru, Shirota Chiyoe, Murase Naruhiko, Oshima Kazuo, Shirotsuki Ryo, Chiba Kosuke, Uchida Hiroo

    PEDIATRIC SURGERY INTERNATIONAL   Vol. 33 ( 10 ) page： 1081 - 1086   2017.10

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  90. Review of redo-Kasai portoenterostomy for biliary atresia in the transition to the liver transplantation era

    Sumida Wataru, Uchida Hiroo, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Murase Naruhiko, Oshima Kazuo, Shirotsuki Ryo, Chiba Kousuke

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 79 ( 3 ) page： 415 - 420   2017.8

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  91. New Navigation Surgery for Resection of Lymphatic Malformations Using Indocyanine Green Fluorescence Imaging.

    Shirota C, Hinoki A, Takahashi M, Tanaka Y, Tainaka T, Sumida W, Murase N, Oshima K, Shirotsuki R, Chiba K, Morimoto Y, Uchida H

    The American journal of case reports   Vol. 18   page： 529 - 531   2017.5

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  92. Fournier's gangrene during ACTH therapy

    Numoto Shingo, Kurahashi Hirokazu, Azuma Yoshiteru, Numaguchi Atsushi, Nakahara Kozaburo, Tainaka Takahisa, Takasu Michihiko, Yamakawa Kiyoshi, Nago Nozomi, Muto Taichiro, Kitagawa Yoshiro, Okumura Akihisa

    BRAIN & DEVELOPMENT   Vol. 39 ( 5 ) page： 435 - 438   2017.5

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  93. Case report of Pierre Robin sequence with severe upper airway obstruction who was rescued by fiberoptic nasotracheal intubation

    Takeshita Satoru, Ueda Hiroko, Goto Tatenobu, Muto Daisuke, Kakita Hiroki, Oshima Kazuo, Tainaka Takahisa, Ono Takayuki, Kazaoka Yoshiaki, Yamada Yasumasa

    BMC ANESTHESIOLOGY   Vol. 17 ( 1 ) page： 43   2017.3

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  94. Laparoscopic resection of neuroblastomas in low-to high-risk patients without image-defined risk factors is safe and feasible

    Shirota Chiyoe, Tainaka Takahisa, Uchida Hiroo, Hinoki Akinari, Chiba Kosuke, Tanaka Yujiro

    BMC PEDIATRICS   Vol. 17 ( 1 ) page： 71   2017.3

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  95. Two-Stage Thoracoscopic Repair of Long-Gap Esophageal Atresia Using Internal Traction Is Safe and Feasible Reviewed

    Tainaka T, Uchida H, Tanano A, Shirota C, Hinoki A, Murase N, Yokota K, Oshima K, Shirotsuki R, Chiba K, Amano H, Kawashima H, Tanaka Y

    J Laparoendosc Adv Surg Tech A   Vol. 27 ( 1 ) page： 71 - 75   2017.1

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    DOI： 10.1089/lap.2016.0207

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  96. Left thoracoscopic two-stage repair of tracheoesophageal fistula with a right aortic arch and a vascular ring. International journal

    Kazuo Oshima, Hiroo Uchida, Takahisa Tainaka, Akihide Tanano, Chiyoe Shirota, Kazuki Yokota, Naruhiko Murase, Ryo Shirotsuki, Kosuke Chiba, Akinari Hinoki

    Journal of minimal access surgery   Vol. 13 ( 1 ) page： 73 - 75   2017

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    A right aortic arch (RAA) is found in 5% of neonates with tracheoesophageal fistulae (TEF) and may be associated with vascular rings. Oesophageal repairs for TEF with an RAA via the right chest often pose surgical difficulties. We report for the first time in the world a successful two-stage repair by left-sided thoracoscope for TEF with an RAA and a vascular ring. We switched from right to left thoracoscopy after finding an RAA. A proximal oesophageal pouch was hemmed into the vascular ring; therefore, we selected a two-stage repair. The TEF was resected and simple internal traction was placed into the oesophagus at the first stage. Detailed examination showed the patent ductus arteriosus (PDA) completing a vascular ring. The subsequent primary oesophago-oesophagostomy and dissection of PDA was performed by left-sided thoracoscope. Therefore, left thoracoscopic repair is safe and feasible for treating TEF with an RAA and a vascular ring.

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  97. Comparing surgical outcomes of complete thoracoscopic lobectomy for congenital cystic lung disease between neonatal and infantile patients Reviewed

    Tainaka T, Uchida H, Tanaka Y, Shirota C, Yokota K, Murase N, Oshima K, Shirotsuki R, Chiba K, Hinoki A

    Nagoya J Med Sci   Vol. 78   page： 447-454   2016.11

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    DOI： 10.18999/nagjms.78.4.447

  98. Large retroperitoneal immature teratoma leading to renovascular hypertension Reviewed

    Tainaka T, Ono Y, Yamada Y, Mutoh D, Uchida H

    Pediatr Int   Vol. 58   page： 1363-1364   2016

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    DOI： 10.1111/ped.13040

  99. A new modification of laparoscopic percutaneous extraperitoneal closure procedure for repairing pediatric femoral hernias involving a special needle and a wire loop. Reviewed

    Tainaka T, Uchida H, Ono Y, Tanano A, Shirota C, Yokota K, Murase N, Makita S, Shirotsuki R.

    Nagoya J Med Sci.   Vol. 77 ( 3 ) page： 531-5   2015.8

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  100. 術中造影、術中検査

    田井中貴久　金子健一朗　小野靖之　土屋博紀　安藤久實

    小児外科   Vol. 42 ( 10 ) page： 1059-1062   2010.10

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  101. Histological assessment of bile lake formation after hepatic portoenterostomy for biliary atresia Reviewed

    Tainaka T, Kaneko K, Nakamura S, Ono Y, Sumida W, Ando H

    Pediatric Sugery International   Vol. 24   page： 265-69   2008

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  102. Intrahapatic cystic lesions after hepatic portoenterostomy for biliary atresia include two entities: Bile lake and dilated bile ducts Reviewed

    Tainaka T, Kaneko K, Seo T, Ono Y, Sumida W, Ando H

    Jounal of Pedeatric Gastroenterology and Nutrition   Vol. 44 ( 1 ) page： 104-107   2007

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  103. Hepatolithiasis after portoenterostomy for biliary atresia Reviewed

    Tainaka T, Kaneko K, Seo T, Ogura Y, Wada H, Shirota C, Ando H

    Journal of Pediatric Surgery   Vol. 41   page： 808-811   2006

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  104. Left paraduodenal hernia leading to protein-losing enteropathy in childhood Reviewed

    Tainaka T, Ikegami R, Watanabe Y

    Journal of Pediatric Surgery   Vol. 40 ( 2 ) page： E21-23   2005

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Books 7

  1. 第117回医師国家試験問題解説書

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    エムスリーエデュケーション  2023.4 

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  2. 第117回医師国家試験問題解説書

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    エムスリーエデュケーション  2023.4 

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    Language：Japanese

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  3. 第116回医師国家試験問題解説書

    田井中貴久（ Role： Contributor）

    エムスリーエデュケーション  2022.4 

  4. 発達段階からみた 小児看護過程

    田井中貴久（ Role： Contributor ,  鎖肛）

    医学書院  2021.10 

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    Responsible for pages：26-29  

  5. スタンダード小児内視鏡外科手術

    田井中貴久（ Role： Contributor ,  鼠径ヘルニア（ヘルニア根治術/SILPEC））

    メジカルビュー社  2020.5 

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    Responsible for pages：128-130   Language：Japanese Book type：Textbook, survey, introduction

  6. スタンダード小児内視鏡外科手術

    田井中貴久（ Role： Contributor ,  ナビゲーション　Indocyanine green）

    メジカルビュー社  2020.5 

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    Responsible for pages：62-63   Language：Japanese Book type：Textbook, survey, introduction

  7. 指定難病ペディア2019

    田井中貴久（ Role： Contributor ,  アラジール症候群）

    日本医師会  2019.6 

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    Responsible for pages：303-304   Language：Japanese Book type：Textbook, survey, introduction

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To the head of Books.▲

MISC 4

  1. 胆道閉鎖症における食道胃静脈瘤の診断に対するshear wave elastographyの有用性

    横山 晋也, 石上 雅敏, 本多 隆, 葛谷 貞二, 石津 洋二, 伊藤 隆徳, 藤城 光弘, 田中 裕次郎, 檜 顕成, 城田 千代栄, 田井中 貴久, 牧田 智, 谷 有希子, 田中 智子, 内田 広夫

    日本小児外科学会雑誌   Vol. 55 ( 3 ) page： 539 - 539   2019.5

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    Language：Japanese   Publisher：(一社)日本小児外科学会  

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  2. 医工連携による生分解性外科手術用デバイスの研究開発

    天野 日出, 檜 顕成, 花田 幸太郎, 三宅 行一, 田井中 貴久, 城田 千代栄, 住田 亙, 横田 一樹, 村瀬 成彦, 大島 一夫, 千馬 耕亮, 藤代 準, 田中 裕次郎, 内田 広夫

    日本外科学会定期学術集会抄録集   Vol. 119回   page： SP - 5   2019.4

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    Language：Japanese   Publisher：(一社)日本外科学会  

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  3. 小児内視鏡外科手術の教育についての工夫と提言 小児高難度内視鏡手術の技術習得には疾患特異的模擬臓器モデルによるOff the Job Trainingは必須である

    出家 亨一, 内田 広夫, 増山 秀徳, 檜 顕成, 石丸 哲也, 藤雄木 亨真, 田中 智子, 大島 一夫, 横田 一樹, 村瀬 成彦, 住田 亙, 田井中 貴久, 城田 千代栄, 藤代 準, 田中 裕次郎

    日本内視鏡外科学会雑誌   Vol. 23 ( 7 ) page： PD6 - 4   2018.12

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    Language：Japanese   Publisher：(一社)日本内視鏡外科学会  

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  4. 体内残存異物とならない亜鉛合金を用いた内視鏡外科手術用デバイスの開発

    天野 日出, 檜 顕成, 三宅 行一, 田井中 貴久, 城田 千代栄, 住田 亙, 横田 一樹, 村瀬 成彦, 大島 一夫, 白月 遼, 千馬 耕亮, 藤代 準, 田中 裕次郎, 内田 広夫

    日本内視鏡外科学会雑誌   Vol. 22 ( 7 ) page： SF023 - 02   2017.12

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    Language：Japanese   Publisher：(一社)日本内視鏡外科学会  

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To the head of MISC.▲

KAKENHI (Grants-in-Aid for Scientific Research) 18

  1. DDS型超分子デバイスを用いた光線力学療法による難治性小児がん根治への試み

    Grant number：16K15741  2016.4 - 2017.3

    科学研究費助成事業   挑戦的萌芽研究

    田井中　貴久

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    Authorship：Principal investigator 

  2. DNAマイクロアレイによる遺伝子分析を用いた胆道閉鎖症予後予測の研究

    Grant number：25861674  2013.4 - 2016.3

    科学研究費助成事業   若手研究(B)

    田井中貴久

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    Authorship：Principal investigator 

  3. Improvement and Validation of a Discriminant Model for Amplification of the Neuroblastoma MYC Gene by Tyrosine Metabolite Markers

    Grant number：23K07308  2023.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship：Coinvestigator(s) 

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  4. 腎芽腫メタボローム解析（尿/組織）による診断マーカーとオンコメタボライト探索

    Grant number：22K07276  2022.4 - 2025.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    岡本 眞宗, 城田 千代栄, 成田 敦, 牧田 智, 田井中 貴久, 内田 広夫, 高橋 義行, 大澤 毅, 住田 亙, 田中 裕次郎, 檜 顕成

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    Authorship：Coinvestigator(s) 

    増殖・浸潤・転移などがんの進展における中心代謝と代謝リプログラミングの役割については未だ不明な点が多い。本研究で腎芽腫細胞に特異的な中心代謝に関与する代謝物（オンコメタボライト）を見出す。がん細胞に特異的な代謝系を見出すことにより、正常細胞の代謝系との違いを標的とする新たながんの治療戦略の開発を目指す。腎芽腫患児の尿、腫瘍組織のキャピラリー電気泳動質量分析法を中心とした代謝物解析により、中心代謝に関与するオンコメタボライトを探索し、従来の集学的治療と遺伝子解析だけでは解明できなかった病態解明及び新たな診断治療法の開発に繋げる。
    Wilms腫瘍は小児の腎腫瘍の中で最も頻度が高い腫瘍であり、小児腎腫瘍の90％を占める。現在ではStageⅠであれば90％以上の5年生存率が得られ治癒可能な病気へと変化してきたが、現行の治療法では未だ十分な治療効果とは言えない。腎動脈や大動脈周囲のリンパ節や肺に転移をきたしやすく、腎静脈から下大静脈内に 腫瘍塞栓を形成することもあり、全体の約10％に予後不良群を認める。最近ではメタボロミクス技術の発展により生体内の代謝情報を鋭敏且つ包括的に捉えることが可能となり、様々な癌種において新たなバイオマーカーや病態の解明が進んでいる。本研究はWilms腫瘍における患児尿と健常コントロール尿の代謝プロファイルの違いや関連を明らかにすることを目的とし、CE/MS:キャピラリー電気泳動質量分析法を中心に代謝物を測定した。（新規サンプル）
    尚、臨床情報付き尿サンプルは採取24時間以内に-80℃で凍結保存し研究に使用する。
    尿10サンプル（Wilms腫瘍・健常コントロール）をキャピラリー電気泳動質量分析法で測定した。現在、Wilms腫瘍で疾患貢献度の高い代謝物の候補を検討中である。
    引き続き、Wilms腫瘍尿において疾患貢献度の高い代謝物をターゲットに、疾病機序の解明、尿中バイオマーカー探索を続けていく。

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  5. 横紋筋肉腫メタボローム解析（尿/組織）による診断マーカーとオンコメタボライト探索

    Grant number：22K07911  2022.4 - 2025.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    住田 亙, 城田 千代栄, 成田 敦, 牧田 智, 田井中 貴久, 内田 広夫, 高橋 義行, 大澤 毅, 田中 裕次郎, 檜 顕成

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    Authorship：Coinvestigator(s) 

    小児の肉腫のなかで最も頻度が高い横紋筋肉腫を標的とし、その中心代謝に関与する代謝産物（オンコメタボライト）及びその特異的な代謝系を見出すことを目標に、生体内の情報を鋭敏且つ包括的に捉えやすいメタボロミクス（キャピラリー電気泳動質量分析法を中心に）に着目する。第一段階として、尿検体を研究サンプルとして用い、尿中代謝物解析（CE/MS:キャピラリー電気泳動質量分析法を中心にLC/MS: 液体クロマトグラフィー質量分析法）から、代謝物を網羅的に測定し、横紋筋肉腫の中心代謝に特異的な代謝物（オンコメタボライト）の解明を目指す。
    横紋筋肉腫は小児肉腫の中で最も頻度が高い希少性・難治性の肉腫であり、小児がんの5～8%を占める。治癒可能な病気へと変化しつつあるが、現行の治療法では未だ十分な治療効果が期待できない。小児横紋筋肉腫の5年無増悪生存率は高リスク群で30~50%と予後不良で現在の診断治療法だけでは未だ十分な治療効果とは言えず、新たな診断治療法の開発が急務である。最近では質量分析計を用いたメタボロミクスの発展により生体内の代謝情報を鋭敏且つ包括的に捉えることが可能となり、様々な癌種において新たなバイオマーカーや病態の解明が進んでいる。メタボロミクスは生命現象そのものを観察することができ、先入観にとらわれず包括的に生命現象を捉えることができる。横紋筋肉腫においても代謝変動の解明が病因解明や新規治療法の開発に寄与すると考えられるが、その代謝変動に着目した診断マーカーや創薬は前例がない。本研究課題の核心をなす学術的「問い」は横紋筋肉腫に特徴的にみられる代謝産物（オンコメタボライト）や代謝系を見出すことである。本研究では横紋筋肉種患児尿サンプルでメタボローム解析を行い、疾患貢献度の高い尿中代謝物（バイオマーカー）を抽出、更に病態解明を目指して代謝物パスウエイ解析を行い検証する。
    ①詳細な臨床情報を有する尿検体の回収(神経芽腫患児および健常者)、②診療情報を生かした横紋筋肉腫検査モデル構築と妥当性の検証、③代謝経路などの代謝リプログラミング解析の計3項目を検討予定である。
    健常者10サンプルと病理組織が胎児型の横紋筋肉腫15サンプルを収集し、尿中代謝物を測定した。LC/MS: 液体クロマトグラフィー質量分析法とCE/MS: キャピラリー電気泳動質量分析法で健常者と胎児型横紋筋肉腫の尿中代謝物を測定・比較し、胎児型横紋筋肉腫で21代謝物の有意な上昇を確認した。
    現在、胎児型横紋筋肉腫にて有意に上昇している代謝経路などの代謝リプログラミング解析も検証中である。
    ①詳細な臨床情報を有する尿検体の回収(横紋筋肉腫患児および健常者)、②診療情報を生かした横紋筋肉腫検査モデル構築と妥当性の検証、③代謝経路などの代謝リプログラミング解析の計3項目を中心に研究を行う。引き続き横紋筋肉腫の悪性度を尿中代謝物で評価するために、横紋筋肉腫の判別に使用できるか検証する必要があると考えている。
    より悪性度が高いとされている病理組織が胞巣型の横紋筋肉腫についても検討を行う。
    本研究では今後もLC/MS:液体クロマトグラフィー質量分析法とCE/MS:キャピラリー電気泳動質量分析法で関連する代謝物を検討する。

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  6. Development of surgical navigation system for esophageal atresia / tracheoesophageal fistula using AI Image analysis and forceps location information

    Grant number：22H03703  2022.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship：Coinvestigator(s) 

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  7. Development of fluorescent probes for diagnosis and treatment of pediatric surgical diseases

    Grant number：21K08640  2021.4 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship：Coinvestigator(s) 

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  8. 腎芽腫患児の代謝物網羅解析によるバイオマーカーの探索と創薬への挑戦

    Grant number：21K07805  2021.4 - 2024.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    田中 裕次郎, 大澤 毅, 内田 広夫, 檜 顕成, 大島 一夫, 城田 千代栄, 田井中 貴久, 住田 亙, 横田 一樹

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    Authorship：Coinvestigator(s) 

    腎芽腫は小児腎腫瘍の90％を占めるが、全体の約10％に予後不良群を認め、診断バイオマーカーが存在しない。最近メタボロミクス技術の発展により生体内の代謝情報を鋭敏且つ包括的に捉えることが可能となり、様々な癌種において新たなバイオマーカーや病態の解明が進んでいる。腎芽腫においても代謝変動の解明が病因解明や新規治療法の開発に寄与すると考えられるが、その代謝変動に着目した診断マーカーや創薬は前例がない。本研究では腎芽腫をターゲットに尿だけでなく、血液、がん組織を加えた腎芽腫50サンプルの代謝物変動を捉えるメタボローム解析を行い、疾患特異的なバイオマーカー探索とその病態解明に挑む。
    腎芽腫（ウイルムス腫瘍）は小児の腎臓に発生する代表的な悪性腫瘍であり、遺伝子異常，合併奇形，関連症候群を呈することが知られている。がん化に伴う遺伝子変異が代謝変動に寄与することは知られているが、増殖・浸潤・転移などがんの進展における代謝リプログラミングの役割については未だ不明な点が多い。がん細胞に特異的な代謝系を見出すことができれば正常細胞の代謝系との違いを標的とする新たながんの治療戦略となる可能性がある。腎芽腫に特異的な代謝系を見出すことを目標に、生体内の情報を鋭敏且つ包括的に捉えやすいメタボロミクスに着目し、第一段階として、収集かつ代謝物の安定性の高い尿検体を研究サンプルとする。本研究は、がん細胞に特異的な代謝系を見出すことにより、正常細胞の代謝系との違いを標的とする新たながんの治療戦略の開発を目指す。昨年に続き今年度も腎芽腫患児と健常コントロール患児の尿サンプルを臨床情報と共に収集、液体クロマトグラフィー質量分析法（LC/MS）で測定し、疾患貢献度の高い尿中代謝物（オスモラリティー補正）を比較検討中である。
    順調に腎芽腫尿サンプル（18サンプル）とコントロールサンプル（110サンプル）を臨床情報付きで収集し、液体クロマトグラフィー質量分析法（LC/MS）で測定した。現在データ解析中。
    引き続き腎芽腫尿サンプル及びコントロールサンプルを収集し、腎芽腫に貢献度の高い代謝物の特定を目指す。

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  9. Development of tracheal stents made from new biodegradable Magnesium alloy

    Grant number：19K22654  2019.6 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

    Uchida Hiroo

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    Authorship：Coinvestigator(s) 

    This study investigated in vitro and in vivo biocompatibility and degradation behavior of biodegradable tracheal stent composed of magnesium (Mg) alloy. Cytotoxicity test revealed in vitro biocompatibility. In the rat experiment, histopathological analysis revealed mild inflammatory reactions around the stent. In the rabbit experiment, there was no significant inflammatory response elevation, liver/renal function failure, or serum Mg concentration elevation in the blood test. However, its degradation rate was too fast; thus, the stent was coated with polylactic acid to reduce the degradation rate. In the rat experiment, Mg alloy stent coated by polylactic acid could keep the shape until six months postoperatively. Therefore, the proposed biodegradable Mg alloy tracheal stent coated with polylactic acid was considered to be a promising treatment device for pediatric tracheomalacia.

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  10. The establish of off the job training for pediatric minimally invasive surgery and automated analysis system of operative technique

    Grant number：19H04225  2019.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Uchida Hiroo

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    Authorship：Coinvestigator(s) 

    Endoscopic surgery on neonates and infants requires the completion of complex procedures while carefully handling fragile tissues, but the small number of patients makes it imperative to enhance off the job training. We held three off-the-job training seminars for pediatric surgeons using our simulators for esophageal atresia, duodenal atresia, and congenital biliary dilatation , with more than 90 pediatric surgeons participating. All participating pediatric surgeons stated that practicing with the simulator was meaningful and should be continued in the future. 3D analysis of forceps movement was completed, and AI image analysis can now be used to determine how well a technique is performed on the simulator for esophageal atresia.

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  11. Challenge to Optimize allocation of Pediatric Surgical Resources by using Remote Medical Platform

    Grant number：17H06280  2017.6 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Pioneering)

    Shirota Chiyoe

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    Authorship：Coinvestigator(s) 

    By developing an application and using one-to-many mobile telemedicine to securely link medical sites, we aimed to solve pediatric surgery medical infrastructure and at the same time spread and develop highly specialized telemedicine support. Many doctors can use the application to create a situation where dispersed cases in each region are aggregated in one place (one-to-many remote video conference, image sharing is possible on a smartphone). Can be shared in real time, participate in the consideration of treatment policy, and exchange opinions. We have started to provide highly specialized telemedicine support, which is available 24 hours a day, by securely linking medical fields with desired doctors and hospitals in Japan. The effective use of the system has made it possible to virtually consolidate a specialist with valuable cases.

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  12. Combined genetic analyses can achieve efficient diagnostic yields for subjects with Alagille syndrome

    Grant number：17K11516  2017.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Sugiura Tokio

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    Authorship：Coinvestigator(s) 

    We evaluated combined genetic analyses with targeted next-generation sequencing
    (NGS), multiplex ligation probe amplification (MLPA) of Jagged1 (JAG1) genes and
    microarray comparative genomic hybridisation (CGH) in subjects with Alagille syndrome,incomplete clinical features of Alagille syndrome and biliary atresia. We analysed 30 subjects with Alagille syndrome, nine with incomplete Alagille syndrome and 17 with biliary atresia and detected pathogenic mutations in JAG1 or NOTCH2 in 24/30 subjects with Alagille syndrome and in 4/9 subjects with incomplete Alagille syndrome. No pathogenic mutations were detected in subjects with biliary atresia. The frequency of JAG1 mutations was as follows: single nucleotide variants (51.9%), small insertion or deletion (29.6%) and gross deletion (18.5%). Combined genetic analyses achieved efficient diagnostic yields for subjects with Alagille syndrome and incomplete Alagille syndrome.

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  13. Establishment of an analytical workflow to elucidate the molecular biology of the pathogenesis of gastrointestinal diseases in neonates

    Grant number：17H04235  2017.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Tanaka Yujiro

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    Authorship：Coinvestigator(s) 

    Lymphocytes of 71 resected human bowels were examined using flow cytometry. Type 3 innate lymphoid cells (ILC3), which is known to regulate bowel immunity, was detected in all specimens. However, the percentage of ILC3 was not constant according to the condition of patients, e.g. gestational week and disease. Studying the bowel specimens of emergency laparotomy in human neonates, we also investigated the differences in gene expression between necrotizing enteritis and non-necrotic intestinal perforation. We studied the gene expression on a cell-by-cell basis of about 10,000 cells per each case, so we can assess what cells were specifically showing abnormal responses. To date, there have been no reports of gene expression analysis on a cell-by-cell basis. In necrotizing enteritis, T cells were dominant and pathways concerning inflammation, e.g. MYC targets, mTORC1 signaling, TNFA signaling were activated. In non-necrotic intestinal perforation, innate monocytic cells were the major.

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  14. Development of a new biodegradable magnesium alloy for medical equipment

    Grant number：16H03197  2016.4 - 2019.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    UCHIDA HIROO

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    Authorship：Coinvestigator(s) 

    We focus on Mg alloy because it is biodegradable, and has excellent biocompatibility. Mg-based medical devices have already been clinically used as vascular stents and orthopaedic screws. However, Mg staples can easily fracture or degrade at the corners of the B-shape after stapling because of their vulnerability to stress corrosion. Another concern is the production of hydrogen gas caused by the rapid corrosion of Mg in physiological environments.
    To address the above challenges, we first redesigned the optimal staple shape to a more rounded form without acute bending points to reduce stress concentrations introduced by stapling and anastomosing. We also developed a novel Mg alloy with sufficiently high ductility to be finely processed to form the shape of a staple and stapled without fracturing. These two patents made us successful in developing Mg alloy staples, and we have confirmed them to be suitable for surgical stapling by rabbit intestinal anastomosis.

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  15. a new wearable multi-lead electrocardiogram measuring system for super-ageing society

    Grant number：16K12957  2016.4 - 2019.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    UCHIDA HIROO

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    Authorship：Coinvestigator(s) 

    To develop a wearable multi-lead electrocardiogram (ECG) measuring system, we fabricated the electrode and wiring by using electrostatic flocking technology on a textile. By using this technology, it was possible to fabricate many electrodes and wiring, simultaneously. The fabricated wiring and electrodes had stretchability and wash resistance properties. To use dry electrodes, it is important to reduce the influence of motion artifacts (MAs). we conducted experiments with a human body to determine the relationship between the contact pressure and the MAs. under the pressures of 1000 Pa , 2000Pa and 4000Pa, the ECG signals under rest and deep breathing conditions were able to be measured without MAs. Finally, we fabricated the wearable ECG measuring system and succeeded in measuring 18-lead ECG signals. The measured ECG waveform is in good agreement with the ECG waveform measured by a commercial system.

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  16. Development of a next generation photothermal therapy using a light-absorbing drug that selectively accumulates in lesions for pediatric cancer

    Grant number：16K15741  2016.4 - 2018.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    TAINAKA Takahisa

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    Authorship：Principal investigator 

    Grant amount：\3380000 （ Direct Cost: \2600000 、 Indirect Cost：\780000 ）

    Even accompanied with infiltration / metastasis, pediatric solid cancer can be curable if the tumor can be completely removed by multidisciplinary treatment, but it is not easy in actual clinical practice. However, applicants have developed a new DDS (Drug Delivery System) type drug "ICG lactosome", which made it possible to carry out diagnosis and therapy simultaneously (Theranostics).ICG lactosome was proved to selectively accumulate in tumor. By fluorescence diagnosis and photothermal treatment using ICG lactosome, we succeeded in shrinking tumors of infiltrated neuroblastoma model mice.Photothermally treated tumor-bearing mice of which the tumor temperature was maintained at 43°C or more during the treatment showed almost completely tumor-extinction.

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  17. DDS型超分子デバイスを用いた光線力学療法による難治性小児がん根治への試み

    2016.4 - 2017.3

    科学研究費補助金  挑戦的萌芽研究、課題番号：16K15741

    田井中 貴久

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    Authorship：Principal investigator 

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  18. Development of Retained Surgical Gauze Detection System before Closing Surgical Incisions.

    Grant number：15K15258  2015.4 - 2018.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    Hinoki Akinari

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    Authorship：Coinvestigator(s) 

    We found retained surgical gauze while creating several types of surgical gauze detection devices and surgical gauze for detection and detecting eddy current of metallic fiber included in the surgical gauze for detection. Actually, metallic fiber were included in surgical gauze and the change of eddy current was detected from the outside of the body before closing incisions, and the presence or absence of remnant gauze was verified. With respect to silver, the search for degradation kinetics in Both quantitative results of metallic element (silver) and pH change of the extract were very small, and it was judged that the influence of silver itself on the human body was extremely small. Considering biocompatibility, metallic resistance, actual detection distance, and decomposition dynamics in simulated environment of silver in the body, at present, it is necessary to set 4 or 16 circular sections (closed loop windings 3 to 7 times) of silver fibers.

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To the head of KAKENHI (Grants-in-Aid for Scientific Research).▲
 

Teaching Experience (On-campus) 4

  1. PBLチュートリアル

    2023

  2. 小児外科学

    2020

  3. 小児外科学

    2018

  4. 小児外科学 新生児外科疾患

    2016

To the head of Teaching Experience (On-campus).▲

Teaching Experience (Off-campus) 5

  1. PBLチュートリアル

    2023 （Nagoya University）

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    Level：Undergraduate (specialized) 

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  2. 小児外科学

    2022.4 - 2023.3 （Toho University）

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    Level：Undergraduate (specialized) 

  3. 小児外科学

    2021.4 - 2022.3 （Toho University）

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    Level：Undergraduate (specialized) 

  4. 小児外科学

    2020 （Nagoya University）

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    Level：Undergraduate (specialized) 

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  5. 小児外科学

    2018 （Nagoya University）

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    Level：Undergraduate (specialized) 

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To the head of Teaching Experience (Off-campus).▲