Updated on 2023/09/26

写真a

 
KATO, Taichi
 
Organization
Graduate School of Medicine Program in Integrated Medicine Medicine in Growth and Aging Associate professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Associate professor

Degree 1

  1. 博士(医学) ( 2003.3   名古屋大学 ) 

Research Interests 2

  1. 先天性心疾患 肺高血圧症 血管生物学 川崎病

  2. 先天性心疾患 肺高血圧症 血管生物学 川崎病

Research Areas 2

  1. Life Science / Embryonic medicine and pediatrics  / Pediatric Cardiology

  2. Life Science / Embryonic medicine and pediatrics

Current Research Project and SDGs 5

  1. 肺高血圧病変形成の機序解明

  2. 川崎病における急性期治療戦略

  3. 川崎病における冠動脈瘤の予後

  4. 先天性心疾患における遺伝学的解析

  5. 学校心臓検診の基準と適正化

Research History 11

  1. Nagoya University   Department of Pediatrics/Developmental Pediatrics   Associate professor

    2017.9

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    Country:Japan

  2. 名古屋大学医学部附属病院小児科 講師

    2011.11 - 2017.8

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    Country:Japan

  3. 名古屋大学医学部附属病院小児科 助教

    2007.4 - 2011.10

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    Country:Japan

  4. 名古屋大学医学部附属病院小児科 助手

    2006.4 - 2007.3

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    Country:Japan

  5. 名古屋大学医学部附属病院小児科 医員

    2005.10 - 2006.3

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    Country:Japan

  6. 社会保険中京病院小児循環器科 医長

    2005.4 - 2005.9

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    Country:Japan

  7. 社会保険中京病院小児循環器科 医員

    2002.4 - 2005.3

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    Country:Japan

  8. 中津川市民病院小児科 医員

    1997.10 - 1998.3

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    Country:Japan

  9. 名古屋大学医学部附属病院小児科 医員

    1997.4 - 1997.9

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    Country:Japan

  10. 名古屋第一赤十字病院小児科 医員

    1996.4 - 1997.3

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    Country:Japan

  11. 名古屋第一赤十字病院 臨床研修医

    1994.4 - 1996.3

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    Country:Japan

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Education 1

  1. Nagoya University   Faculty of Medicine

    1988.4 - 1994.3

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    Country: Japan

Professional Memberships 10

  1. 日本小児科学会   代議員

  2. 日本小児循環器学会   評議員、教育委員、社会制度委員会学校検診部会委員

    2000.4

  3. 日本循環器学会

  4. American Heart Association

  5. 日本川崎病学会   理事

  6. 日本人類遺伝学会

  7. 日本内科学会

  8. 日本超音波医学会

  9. 日本小児心筋疾患学会   幹事

  10. 日本肺高血圧肺循環学会

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Committee Memberships 4

  1. 愛知県医師会学校健診委員会   学校健診委員  

    2010.4   

  2. 名古屋市学校医会心臓専門医委員   委員  

    2010.4   

  3. 愛知県医師会学校健診委員会   学校健診委員  

    2010.4   

  4. 名古屋市学校医会心臓専門医委員   委員  

    2010.4   

Awards 1

  1. 第43回小児循環器学会会長賞(優秀賞)

    2007.7   日本小児循環器学会  

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    Country:Japan

 

Papers 53

  1. Analysis of Coronary Arterial Aneurysm Regression in Patients With Kawasaki Disease by Aneurysm Severity: Factors Associated With Regression. Reviewed International journal

    Taichi Kato, Masaru Miura, Tohru Kobayashi, Tetsuji Kaneko, Naoya Fukushima, Kenji Suda, Jun Maeda, Shinya Shimoyama, Junko Shiono, Keiichi Hirono, Kazuyuki Ikeda, Seiichi Sato, Fujito Numano, Yoshihide Mitani, Kenji Waki, Mamoru Ayusawa, Ryuji Fukazawa, Shigeto Fuse

    Journal of the American Heart Association   Vol. 12 ( 3 ) page: e022417   2023.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Background Coronary arterial aneurysms (CAAs) associated with Kawasaki disease (KD) significantly affect prognosis. However, the clinical course of CAAs and factors associated with CAA regression have not been well analyzed. Methods and Results The cohort of the Z-Score 2nd Project Stage study, a multicenter, retrospective, cohort study involving 44 institutions in Japan including 1006 patients with KD, was examined. CAAs were classified by the z score of their internal diameter in the acute phase: small (z<5), medium (5≤z<10), and large (z≥10). The lower limit of small CAA was based on the Japanese Ministry of Health, Labour and Welfare criteria. In the right coronary artery, the CAA regression rates 10 years after diagnosis were 95.5% for small, 83.2% for medium, and 36.3% for large. In the proximal left anterior descending artery, the regression rates 10 years after diagnosis were 95.3% for small, 80.1% for medium, and 28.8% for large. Cox regression analysis showed that diagnosis under the age of 1 year and onset of KD in 2010 to 2012 for the right coronary artery and the left anterior descending artery, and female for the right coronary artery were significantly associated with a high regression rate, whereas large CAAs for the right coronary artery and the left anterior descending artery were significantly associated with a low regression rate. Conclusions The current study, the largest Japanese study of its kind, found that small aneurysm, recent onset, and diagnosis under the age of 1 year predict regression, and that even giant aneurysms could regress. These data may contribute to long-term management of coronary aneurysms. Registration URL: https://www.umin.ac.jp/ctr/; Unique identifier: UMIN000010606.

    DOI: 10.1161/JAHA.121.022417

    Scopus

    PubMed

  2. An electrocardiographic score to predict pulmonary hypertension in children with atrial septal defect. Reviewed International coauthorship

    Indah K Murni, Taichi Kato, Muhammad Taufik Wirawan, Nadya Arafuri, Kristia Hermawan, Anggoro Budi Hartopo, Dyah Wulan Anggrahini, Sasmito Nugroho, Noormanto Noormanto, Noriaki Emoto and Lucia Kris Dinarti.

    BMC Pediatr.   Vol. 23 ( 1 ) page: 288   2023.1

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12887-023-04102-1.

  3. Conception by assisted reproductive technology in infants with critical congenital heart disease in Japan. Reviewed

    Morimoto Y, Go K, Yamamoto H, Fukasawa Y, Nakai M, Morihana E, Yasuda K, Nishikawa H, Ohashi N, Takahashi Y, Kato T

    Reproductive biomedicine online   Vol. 44 ( 1 ) page: 163 - 170   2022.1

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    Authorship:Last author, Corresponding author   Language:English  

    DOI: 10.1016/j.rbmo.2021.10.005

    PubMed

  4. Successful treatment of a novel type I interferonopathy due to a de novo PSMB9 gene mutation with a Janus kinase inhibitor. Reviewed International journal

    Shinsuke Kataoka, Nozomu Kawashima, Yusuke Okuno, Hideki Muramatsu, Shunsuke Miwata, Kotaro Narita, Motoharu Hamada, Norihiro Murakami, Rieko Taniguchi, Daisuke Ichikawa, Hironobu Kitazawa, Kyogo Suzuki, Eri Nishikawa, Atsushi Narita, Nobuhiro Nishio, Hidenori Yamamoto, Yoshie Fukasawa, Taichi Kato, Hiroyuki Yamamoto, Jun Natsume, Seiji Kojima, Ichizo Nishino, Takeshi Taketani, Hidenori Ohnishi, Yoshiyuki Takahashi

    The Journal of allergy and clinical immunology   Vol. 148 ( 2 ) page: 639 - 644   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Type I interferonopathies are a recently established subgroup of autoinflammatory diseases caused by mutations in genes associated with proteasome degradation or cytoplasmic RNA- and DNA-sensing pathways. OBJECTIVE: This study aimed to unveil the molecular pathogenesis of a patient with novel type I interferonopathy, for which no known genetic mutations have been identified. METHODS: We performed the whole-exome sequencing of a 1-month-old boy with novel type I interferonopathy. We also investigated proteasome activities using patient-derived B lymphoblastoid cell lines (LCLs) and normal LCLs transduced with the mutant gene. RESULTS: Whole-exome sequencing identified a de novo proteasome 20S subunit beta 9 (PSMB9) p.G156D mutation in the patient who developed fever, a chilblain-like skin rash, myositis, and severe pulmonary hypertension due to the hyperactivation of IFN-α. Patient-derived LCLs revealed reduced proteasome activities, and exogenous transduction of mutant PSMB9 p.G156D into normal LCLs significantly suppressed proteasome activities, and the endogenous PSMB9 protein was lost along with the reduction of other immunoproteasome subunits, PSMB8 and PSMB10 proteins. He responded to the administration of a Janus kinase inhibitor, tofacitinib, and he was successfully withdrawn from venoarterial extracorporeal membranous oxygenation. At age 7 months, he received an unrelated cord blood transplantation. At 2 years posttransplantation, he no longer required tofacitinib and experienced no disease recurrence. CONCLUSIONS: We present the case of a patient with a novel type I interferonopathy caused by a de novo PSMB9 p.G156D mutation that suppressed the wild-type PSMB9 protein expression. Janus kinase inhibitor and stem cell transplantation could be curative therapies in patients with severe interferonopathies.

    DOI: 10.1016/j.jaci.2021.03.010

    PubMed

  5. Phosphorylated proteome analysis of a novel germline ABL1 mutation causing an autosomal dominant syndrome with ventricular septal defect Reviewed International journal

    Yamamoto Hidenori, Hayano Satoshi, Okuno Yusuke, Onoda Atsuto, Kato Kohji, Nagai Noriko, Fukasawa Yoshie, Saitoh Shinji, Takahashi Yoshiyuki, Kato Taichi

    INTERNATIONAL JOURNAL OF CARDIOLOGY   Vol. 326   page: 81 - 87   2021.3

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijcard.2020.10.032

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  6. Revision of diagnostic guidelines for Kawasaki disease (6th revised edition). Reviewed International journal

    Kobayashi T, Ayusawa M, Suzuki H, Abe J, Ito S, Kato T, Kamada M, Shiono J, Suda K, Tsuchiya K, Nakamura T, Nakamura Y, Nomura Y, Hamada H, Fukazawa R, Furuno K, Matsuura H, Matsubara T, Miura M, Takahashi K

    Pediatrics international : official journal of the Japan Pediatric Society   Vol. 62 ( 10 ) page: 1135 - 1138   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ped.14326

    PubMed

  7. Mesenchymal stem/stromal cells stably transduced with an inhibitor of CC chemokine ligand 2 ameliorate bronchopulmonary dysplasia and pulmonary hypertension Reviewed International journal

    Suzuki Toshihiko, Sato Yoshiaki, Yamamoto Hidenori, Kato Taichi, Kitase Yuma, Ueda Kazuto, Mimatsu Haruka, Sugiyama Yuichiro, Onoda Atsuto, Saito Shigeki, Takahashi Yoshiyuki, Nakayama Takayuki, Hayakawa Masahiro

    CYTOTHERAPY   Vol. 22 ( 4 ) page: 180 - 192   2020.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jcyt.2020.01.009

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  8. A non-selective endothelin receptor antagonist bosentan modulates kinetics of bone marrow-derived cells in ameliorating pulmonary hypertension in mice Reviewed International journal

    Kato Taichi, Mitani Yoshihide, Masuya Masahiro, Maruyama Junko, Sawada Hirofumi, Ohashi Hiroyuki, Ikeyama Yukiko, Otsuki Shoichiro, Yodoya Noriko, Shinohara Tsutomu, Miyata Eri, Zhang Erquan, Katayama Naoyuki, Shimpo Hideto, Maruyama Kazuo, Komada Yoshihiro, Hirayama Masahiro

    PULMONARY CIRCULATION   Vol. 10 ( 2 ) page: 2045894020919355   2020.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/2045894020919355

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  9. The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension. Reviewed International coauthorship International journal

    Morikawa M, Mitani Y, Holmborn K, Kato T, Koinuma D, Maruyama J, Vasilaki E, Sawada H, Kobayashi M, Ozawa T, Morishita Y, Bessho Y, Maeda S, Ledin J, Aburatani H, Kageyama R, Maruyama K, Heldin CH, Miyazono K

    Science signaling   Vol. 12 ( 607 ) page: eaay4430 - eaay4430   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Association for the Advancement of Science (AAAS)  

    Dysregulated bone morphogenetic protein (BMP) signaling in endothelial cells (ECs) is implicated in vascular diseases such as pulmonary arterial hypertension (PAH). Here, we showed that the transcription factor ATOH8 was a direct target of SMAD1/5 and was induced in a manner dependent on BMP but independent of Notch, another critical signaling pathway in ECs. In zebrafish and mice, inactivation of <italic>Atoh8</italic> did not cause an arteriovenous malformation–like phenotype, which may arise because of dysregulated Notch signaling. In contrast, <italic>Atoh8-</italic>deficient mice exhibited a phenotype mimicking PAH, which included increased pulmonary arterial pressure and right ventricular hypertrophy. Moreover, <italic>ATOH8</italic> expression was decreased in PAH patient lungs. We showed that in cells, ATOH8 interacted with hypoxia-inducible factor 2α (HIF-2α) and decreased its abundance, leading to reduced induction of HIF-2α target genes in response to hypoxia. Together, these findings suggest that the BMP receptor type II/ALK-1/SMAD/ATOH8 axis may attenuate hypoxic responses in ECs in the pulmonary circulation and may help prevent the development of PAH.

    DOI: 10.1126/scisignal.aay4430

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  10. Frequent intragenic microdeletions of elastin in familial supravalvul araortic stenosis (vol 274, pg 290, 2019) Reviewed International journal

    Hayano Satoshi, Okuno Yusuke, Tsutsumi Makiko, Inagaki Hidehito, Fukasawa Yoshie, Kurahashi Hiroki, Kojima Seiji, Takahashi Yoshiyuki, Kato Taichi

    INTERNATIONAL JOURNAL OF CARDIOLOGY   Vol. 292   page: 283 - 283   2019.10

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    DOI: 10.1016/j.ijcard.2019.06.020

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  11. Investigation of novel variations of ORAI1 gene and their association with Kawasaki disease

    Thiha K., Mashimo Y., Suzuki H., Hamada H., Hata A., Hara T., Tanaka T., Ito K., Onouchi Y., Masuda H., Kobayashi T., Jibiki T., Yamazaki T., Ohkuma Y., Fujiwara M., Kobayashi T., Takeuchi H., Ouchi K., Mizuno Y., Fuse S., Fukazawa N., Saji T., Takatsuki S., Nishimura K., Hamada H., Fukazawa R., Nishumura H., Aso K., Matsubara T., Mizuno T., Iwashima S., Ayusawa M., Ikeda K., Kosuda T., Hashimoto K., Hirasawa K., Miura M., Somura J., Toba E., Hirono K., Nomura Y., Arakawa H., Ogata S., Kajino H., Kawamura S., Aoyagi H., Suzuki H., Ichinose K., Shimozono A., Kato Y., Higashikawa M., Kawamura Y., Misawa M., Nagai N., Kato T., Nagata D., Okamoto A., Suzuki H., Kishiro M., Shiono J., Higashi K., Yokoyama N., Ebata R., Onouchi Y.

    Journal of Human Genetics   Vol. 64 ( 6 ) page: 511 - 519   2019.6

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    ORAI1 encodes a calcium channel essential in the store-operated calcium entry mechanism. A previous genetic association study identified a rare in-frame insertion variant of ORAI1 conferring Kawasaki disease (KD). To deepen our understanding of the involvement of rare variants of ORAI1 in KD pathogenesis, we investigated 3812 patients with KD and 2644 healthy individuals for variations in the protein-coding region of ORAI1. By re-sequencing the study participants’ DNA, 27 variants with minor allele frequencies (MAFs) < 0.01 that had not been examined in the previous study were identified. Although no significant association with KD was observed either in single-variant analyses or in a collapsing method analysis of the 27 variants, stratification by MAFs, variant types, and predicted deleteriousness revealed that six rare, deleterious, missense variants (MAF < 0.001, CADD C-score ≥ 20) were exclusively present in KD patients, including three refractory cases (OR = ∞, P = 0.046). The six missense variants include p.Gly98Asp, which has been demonstrated to result in gain of function leading to constitutive Ca2+ entry. Conversely, five types of frameshift variants, all identified near the N terminus and assumed to disrupt ORAI1 function, showed an opposite trend of association (OR = 0.35, P = 0.24). These findings support our hypothesis that genetic variations causing the upregulation of the Ca2+/NFAT pathway confer susceptibility to KD. Our findings also provide insights into the usefulness of stratifying the variants based on their MAFs and on the direction of the effects on protein function when conducting association studies using the gene-based collapsing method.

    DOI: 10.1038/s10038-019-0588-2

    Scopus

  12. Frequent intragenic microdeletions of elastin in familial supravalvular aortic stenosis Reviewed

    Hayano Satoshi, Okuno Yusuke, Tsutsumi Makiko, Inagaki Hidehito, Fukasawa Yoshie, Kurahashi Hiroki, Kojima Seiji, Takahashi Yoshiyuki, Kato Taichi

    INTERNATIONAL JOURNAL OF CARDIOLOGY   Vol. 274   page: 290-295   2019.1

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    DOI: 10.1016/j.ijcard.2018.09.032

    Web of Science

    PubMed

  13. Guidelines for Heart Disease Screening in Schools (JCS 2016/JSPCCS 2016) - Digest Version Reviewed International journal

    Sumitomo N, Baba R, Doi S, Higaki T, Horigome H, Ichida F, Ishikawa H, Iwamoto M, Izumida N, Kasamaki Y, Kuga K, Mitani Y, Musha H, Nakanishi T, Yoshinaga M, Abe K, Ayusawa M, Hokosaki T, Kato T, Kato Y, Ohta K, Sawada H, Ushinohama H, Yoshiba S, Atarashi H, Hirayama A, Horie M, Nagashima M, Niwa K, Ogawa S, Okumura K, Tsutsui H

    CIRCULATION JOURNAL   Vol. 82 ( 9 ) page: 2385 - 2444   2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-66-0153

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  14. Association of Severity of Coronary Artery Aneurysms in Patients With Kawasaki Disease and Risk of Later Coronary Events. Reviewed International journal

    JAMA pediatrics   Vol. 172 ( 5 ) page: e180030   2018.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1001/jamapediatrics.2018.0030

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  15. A New Z-Score Curve of the Coronary Arterial Internal Diameter Using the Lambda-Mu-Sigma Method in a Pediatric Population. Reviewed

    Kobayashi T, Fuse S, Sakamoto N, Mikami M, Ogawa S, Hamaoka K, Arakaki Y, Nakamura T, Nagasawa H, Kato T, Jibiki T, Iwashima S, Yamakawa M, Ohkubo T, Shimoyama S, Aso K, Sato S, Saji T; Z Score Project Investigators.

    JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY   Vol. 2016 ( 29 ) page: 794-801   2016.10

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    DOI: doi:10.1016/j.echo.2016.03.017.

  16. Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and anti-oxidant effects. Reviewed

    Kishimoto Y, Kato T, Ito M, Azuma Y, Fukasawa Y, Ohno K, Kojima S.

    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY   Vol. 150 ( 3 ) page: 645-654.e3.   2015

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  17. Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease: a prospective, randomised, open, blinded-endpoint trial. Reviewed

    Kobayashi T, Saji T, Otani T, Takeuchi K, Nakamura T, Arakawa H, Kato T, Hara T, Hamaoka K, Ogawa S, Miura M, Nomura Y, Fuse S, Ichida F, Seki M, Fukazawa R, Ogawa C, Furuno K, Tokunaga H, Takatsuki S, Hara S, Morikawa A, RAISE Study Group Investigators.

      Vol. 379   page: 1613-1620   2012

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  18. Case report: High-dose epoprostenol therapy in pediatric patients with pulmonary hypertension and developmental lung disease. Reviewed

    Fukasawa Y, Yamamoto H, Ito M, Saito A, Go K, Morimoto Y, Yasuda K, Sato Y, Hayakawa M, Kato T

    Frontiers in pediatrics   Vol. 11   page: 1116434   2023.3

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    Authorship:Last author, Corresponding author   Language:English   Publisher:Frontiers in Pediatrics  

    Pulmonary hypertension (PH) with developmental lung disease is a life-threatening disease and accounts for 10%–12% of pediatric PH patients. Administration of specific pulmonary vasodilators to pediatric PH patients has brought about improvement of their long-term prognosis. Intravenous epoprostenol therapy is a gold standard therapy for severe idiopathic pulmonary arterial hypertension (IPAH), but there are few reports demonstrating the efficacy of epoprostenol for pediatric PH patients with developmental lung disease, especially when treating with high doses of epoprostenol. Two cases of pediatric PH patients with alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) and congenital diaphragmatic hernia (CDH) with bronchopulmonary dysplasia (BPD), respectively, treated with epoprostenol above 100 ng/kg/min are presented. In these two cases, severe PH was improved significantly by an aggressive increase of the epoprostenol infusion rate with administration of oral pulmonary vasodilators and appropriate respiratory management, without any significant adverse effects. High-dose epoprostenol therapy may be one of the therapeutic options in pediatric PH patients with developmental lung disease.

    DOI: 10.3389/fped.2023.1116434

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    PubMed

  19. Effects of general anesthesia on the results of cardiac catheterization in pediatric patients with ventricular septal defect Reviewed

    Go K, Kato T, Kito M, Morimoto Y, Kawai S, Yamamoto H, Fukasawa Y, Yasuda K.

    congenital heart disease   Vol. 18 ( 2 ) page: 235 - 243   2023.3

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  20. Using Biomarkers to Predict Unresponsiveness to Initial Immunoglobulin for Kawasaki Disease Patients. Invited

    Kato T

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 86 ( 6 ) page: 984 - 985   2022.5

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    Authorship:Lead author, Last author, Corresponding author   Language:English  

    DOI: 10.1253/circj.CJ-21-0821

    PubMed

  21. Familial cardiac septal defect due to a novel nine-base deletion in TBX20. Reviewed

    Yamamoto H, Inagaki H, Hayano S, Kurahashi H, Kato T

    Pediatrics international : official journal of the Japan Pediatric Society   Vol. 64 ( 1 ) page: e14995   2022.1

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    Authorship:Last author, Corresponding author   Language:English  

    DOI: 10.1111/ped.14995

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  22. Tension hemothorax 1 week after pericardiocentesis associated with thrombocytopenia. Reviewed

    Yamamoto H, Go K, Morimoto Y, Fukasawa Y, Kato T

    Pediatrics international : official journal of the Japan Pediatric Society   Vol. 64 ( 1 ) page: e15395   2022.1

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    Authorship:Corresponding author   Language:English  

    DOI: 10.1111/ped.15395

    PubMed

  23. Electrocardiographic Diagnosis of Hypertrophic Cardiomyopathy in the Pre- and Post-Diagnostic Phases in Children and Adolescents. Reviewed

    Yoshinaga M, Horigome H, Ayusawa M, Yasuda K, Kogaki S, Doi S, Tateno S, Ohta K, Hokosaki T, Nishihara E, Iwamoto M, Sumitomo N, Ushinohama H, Izumida N, Tauchi N, Kato Y, Kato T, Chisaka T, Higaki T, Yoneyama T, Abe K, Nozaki Y, Komori A, Kawai S, Ninomiya Y, Tanaka Y, Nuruki N, Sonoda M, Ueno K, Hazeki D, Nomura Y, Sato S, Hirono K, Hosokawa S, Takechi F, Ishikawa Y, Hata T, Ichida F, Ohno S, Makita N, Horie M, Matsushima S, Tsutsui H, Ogata H, Takahashi H, Nagashima M

    Circulation journal : official journal of the Japanese Circulation Society     2021.10

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    DOI: 10.1253/circj.CJ-21-0376

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  24. Echocardiography Monitoring of Pulmonary Hypertension after Pediatric Hematopoietic Stem Cell Transplantation: Pediatric Pulmonary Arterial Hypertension and Pulmonary Veno-Occlusive Disease after Hematopoietic Stem Cell Transplantation. Reviewed International journal

    Nozomu Kawashima, Yoshie Fukasawa, Eri Nishikawa, Keiko Ohta-Ogo, Hatsue Ishibashi-Ueda, Motoharu Hamada, Daisuke Ichikawa, Atsushi Narita, Yusuke Okuno, Hideki Muramatsu, Nobuhiro Nishio, Seiji Kojima, Taichi Kato, Yoshiyuki Takahashi

    Transplantation and cellular therapy   Vol. 27 ( 9 ) page: 786.e1 - 786.e8   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    Pulmonary hypertension (PH) is associated with high morbidity in children undergoing hematopoietic stem cell transplantation (HSCT). However, owing to the lack of sequential echocardiography, the nature of the condition is not fully understood. This study was conducted to investigate whether routine echocardiography performed after HSCT could detect patients with PH at an earlier stage and elucidate the role of intervention using tadalafil. The study population comprised 93 consecutive children age <18 years who underwent a total of 109 HSCTs. All patients underwent routine transthoracic echocardiography during HSCT. Four children (4%) with a median age of 4 years (range, 0.7 to 6 years) were found to have PH, and their median tricuspid regurgitation peak velocity (TRV) was 4.1 m/s (range, 3.5 to 4.2 m/s). PH was diagnosed at a median of 52 days (range, 21 to 118 days) after HSCT. Three of them were diagnosed with neuroblastoma, and 1 was diagnosed with infantile leukemia. One patient developed PH after autologous HSCT, and 3 received killer immunoglobulin-like receptor ligand-mismatched cord blood. Busulfan was used for conditioning in all patients, and the proportion of patients receiving this medication was significantly higher in the PH group compared with the non-PH group (100% versus 30%; P = .011). Three of the 4 patients had a durable response (TRV ≤2.8 m/s) at a median of 46 days (range, 14 to 79 days) after starting treatment with tadalafil. No patient experienced exacerbation of PH, and treatment was completed at median of 96 days (range, 46 to 212 days). Our data suggest that routine echocardiography monitoring after HSCT should be considered in children receiving busulfan, although the precise follow-up timing needs further study. In addition, safe and effective administration of tadalafil must be ensured by close monitoring.

    DOI: 10.1016/j.jtct.2021.05.017

    PubMed

  25. Serum tenascin-C predicts resistance to steroid combination therapy in high-risk Kawasaki disease: a multicenter prospective cohort study. Reviewed

    Yoshikane Y, Okuma Y, Miyamoto T, Hashimoto J, Fukazawa R, Kato T, Takeda A, Suda K, Matsushita T, Hiroe M, Imanaka-Yoshida K

    Pediatric rheumatology online journal   Vol. 19 ( 1 ) page: 82   2021.6

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    Language:English  

    DOI: 10.1186/s12969-021-00562-w

    PubMed

  26. Comprehensive pathogen detection in sera of Kawasaki disease patients by high-throughput sequencing: a retrospective exploratory study Reviewed International journal

    Torii Yuka, Horiba Kazuhiro, Hayano Satoshi, Kato Taichi, Suzuki Takako, Kawada Jun-ichi, Takahashi Yoshiyuki, Kojima Seiji, Okuno Yusuke, Ogi Tomoo, Ito Yoshinori

    BMC PEDIATRICS   Vol. 20 ( 1 ) page: 482   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12887-020-02380-7

    Web of Science

    PubMed

  27. Two-incision technique for the subcutaneous implantable cardioverter defibrillator Reviewed International journal

    Nomura Yoji, Kato Taichi, Nishihara Eiki, Morishima Itsuro, Kuraishi Kenji

    PEDIATRICS INTERNATIONAL   Vol. 62 ( 6 ) page: 736 - 738   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ped.14252

    Web of Science

    PubMed

  28. A Diversified Approach for the Prevention of Pediatric Sudden Cardiovascular Death in Japan Invited International journal

    Kato Taichi

    CIRCULATION JOURNAL   Vol. 84 ( 4 ) page: 544 - 545   2020.4

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    Authorship:Lead author, Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-20-0139

    Web of Science

    PubMed

  29. Influence of Percutaneous Occlusion of Atrial Septal Defect on Left Atrial Function Evaluated Using 2D Speckle Tracking Echocardiography Reviewed International journal

    Suzuki Kazutaka, Kato Taichi, Koyama Satoshi, Shinohara Tsutomu, Inukai Sachiko, Sato Jun, Yamamoto Hidenori, Omori Daisuke, Yoshida Shuichiro, Takeda Sho, Nishikawa Hiroshi, Ohashi Naoki, Sakurai Hajime, Saitoh Shinji

    INTERNATIONAL HEART JOURNAL   Vol. 61 ( 1 ) page: 83 - 88   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1536/ihj.19-173

    Web of Science

    PubMed

  30. Severe fetal cardiomegaly caused by multiple non-giant placental chorioangiomas Reviewed International journal

    Yamamoto Hidenori, Fukasawa Yoshie, Kato Taichi

    CARDIOLOGY IN THE YOUNG   Vol. 29 ( 12 ) page: 1559 - 1560   2019.12

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1017/S1047951119002567

    Web of Science

    PubMed

  31. Prediction of postnatal clinical course in primary congenital dilated cardiomyopathy Reviewed International journal

    Yamamoto Hidenori, Fukasawa Yoshie, Ohashi Naoki, Yokoyama Takehiko, Suzuki Kazutaka, Ota Takaya, Yasuda Kazushi, Omoya Kentaro, Takahashi Yoshiyuki, Kato Taichi

    PEDIATRICS INTERNATIONAL   Vol. 61 ( 12 ) page: 1196 - 1201   2019.12

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ped.14029

    Web of Science

    PubMed

  32. Ventricular tachycardia and chest pain due to foreign body in the pericardium caused by self-injurious behaviour Reviewed

    Yamamoto Hidenori, Fukasawa Yoshie, Kato Taichi

    CARDIOLOGY IN THE YOUNG   Vol. 29 ( 9 ) page: 1217 - 1218   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1017/S1047951119001744

    Web of Science

    PubMed

  33. Successful treatment of esophageal bleeding due to rupture of major aortopulmonary collateral arteries by transcatheter arterial embolization Reviewed

    Ito Takanori, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Matsushima Masaya, Kato Taichi, Hirooka Yoshiki

    CLINICAL JOURNAL OF GASTROENTEROLOGY   Vol. 12 ( 1 ) page: 20 - 24   2019.2

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    Major aortopulmonary collateral arteries (MAPCAs) are unique vessels associated with hypoxia induced by congenital heart disease (CHD). Although MAPCAs are essential to supply blood to the lungs, their development and proliferation can induce life-threatening complications, such as rupture into the lung. Here, we describe a rare case of esophageal bleeding from MAPCAs in a CHD patient, which was successfully treated by transcatheter arterial embolization (TAE). A 16-year-old male with CHD experienced a hematemesis and melena after the Bentall procedure to treat valvular heart disease. Emergent esophagogastroduodenoscopy revealed spurting bleeding from the middle esophageal vessels; accordingly, endoscopic variceal ligation (EVL) was performed. However, he had a hematemesis again after 2 weeks of EVL. The arterial phase of dynamic computed tomography indicated that a MAPCA associated with CHD was the origin of bleeding. Hence, TAE of this MAPCA with a mixture of n-butyl-2-cyanoacrylate and ethiodized oil was performed to prevent re-bleeding. Color Doppler mode in endoscopic ultrasonography via the esophagus revealed mosaic-like signals in MAPCAs located in the esophageal wall. This finding was consistent with tortuous MAPCAs accompanied by turbulent blood flow. When clinicians encounter CHD patients with unexpected massive esophageal bleeding, bleeding related to MAPCAs should be considered.

    DOI: 10.1007/s12328-018-0895-8

    Web of Science

    PubMed

  34. Identification of potential pathogenic viruses in patients with acute myocarditis using next-generation sequencing Reviewed

    Takeuchi Suguru, Kawada Jun-ichi, Okuno Yusuke, Horiba Kazuhiro, Suzuki Takako, Torii Yuka, Yasuda Kazushi, Numaguchi Atsushi, Kato Taichi, Takahashi Yoshiyuki, Ito Yoshinori

    JOURNAL OF MEDICAL VIROLOGY   Vol. 90 ( 12 ) page: 1814-1821   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jmv.25263

    Web of Science

    PubMed

  35. 小児循環器疾患の基礎研究から臨床への応用 家族性大動脈弁上狭窄において、遺伝子内微小欠失の頻度は高い 次世代シーケンサーによる7家系の解析と臨床応用への可能性 Reviewed

    早野 聡, 奥野 友介, 堤 真紀子, 稲垣 秀人, 深澤 佳絵, 倉橋 浩樹, 小島 勢二, 高橋 義行, 加藤 太一

    日本小児循環器学会雑誌   Vol. 34 ( Suppl.1 ) page: s1 - 122   2018.7

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    Language:Japanese   Publisher:(NPO)日本小児循環器学会  

  36. Infliximab versus intravenous immunoglobulin for refractory Kawasaki disease: a phase 3, randomized, open-label, active-controlled, parallel-group, multicenter trial Reviewed International journal

    Mori M, Hara T, Kikuchi M, Shimizu H, Miyamoto T, Iwashima S, Oonishi T, Hashimoto K, Kobayashi N, Waki K, Suzuki Y, Otsubo Y, Yamada H, Ishikawa C, Kato T, Fuse S.

    Sci Rep   Vol. 8 ( 1 ) page: 1994   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-18387-7

    PubMed

  37. Successful Infant Pneumonectomy with Unilateral Pulmonary Artery Occlusion Test. Reviewed

    Koji Kato, Taichi Kato, Satoshi Hayano, Yoshie Fukasawa, Atsushi Numaguchi, Tetsuo Hattori, Akiko Saito, Yoshiaki Sato, Masahiro Hayakawa

    International heart journal   Vol. 59 ( 1 ) page: 237 - 239   2018.1

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    The use of unilateral pulmonary artery occlusion (UPAO) test for the preoperative evaluation of pneumonectomy was reported in adult patients. On the contrary, in infants, no strategies have yet been recommended to predict hemodynamics after pneumonectomy, nor has use of the UPAO test been reported. We describe the first case of infant with abnormal pulmonary circulation in whom successful pneumonectomy was performed after preoperative evaluation using UPAO test. Right pneumonectomy was planned for an 8-month-old girl, because of decreased right pulmonary function, high risk of pneumothorax, and impaired left lung expansion due to overexpansion caused by severe left bronchial stenosis and bronchomalacia. However, she had also prolonged pulmonary hypertension and there was difficulty in accurate echocardiographic evaluation of its severity due to concomitant left pulmonary artery stenosis. Furthermore, contrast-enhanced computer tomography suggested a certain degree of right pulmonary venous flow, discordant with the result showing scarce right pulmonary flow in perfusion scintigraphy. Predicting postoperative hemodynamic changes was therefore considered difficult. To evaluate these concerns, we performed cardiac catheterization and UPAO test to simulate postoperative hemodynamics. Pulmonary arteriography showed decreased but significant right pulmonary arterial and venous flows. Measurements including pulmonary artery pressure and cardiac index showed no marked changes after occlusion. Based on UPAO test results, the operation was successfully performed and hemodynamics remained stable postoperatively. The UPAO test may be useful for infants with cardiopulmonary impairment to evaluate the tolerability of pneumonectomy.

    DOI: 10.1536/ihj.16-606

    PubMed

  38. 先天性心疾患の手術非介入で経過している 18 トリソミーの検討 Reviewed

    今井 祐喜 ,加藤 太一 ,加藤 有一 ,久保田 哲夫 ,服部 哲夫

    日小児循環器会誌   Vol. 33 ( 4 ) page: 312-317   2017

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  39. Screening of Pulmonary Arteriovenous Malformations and Genetic Test in Patients with Hereditary Hemorrhagic Telangiectasia

    Kato Taichi

    Pediatric Cardiology and Cardiac Surgery   Vol. 33 ( 3 ) page: 247 - 248   2017

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    Language:Japanese   Publisher:Japanese Society of Pediatric Cardiology and Cardiac Surgery  

    DOI: 10.9794/jspccs.33.247

    CiNii Research

  40. Primary psoas abscess caused by group A streptococcus in a child: Case report with microbiologic findings. Reviewed

    Kamiya Y, Hasegawa T, Takegami Y, Horiba K1, Ando S, Torii Y, Kidokoro H, Kato T, Natsume J, Kawada JI, Ito Y.

    J Infect Chemother   Vol. 22 ( 12 ) page: 811-814   2016.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jiac.2016.06.011.

  41. Abnormal urinalysis on day 7 in patients with IgA vasculitis (Henoch-Schonlein purpura) Reviewed

    Kawashima N, Kawada J, Nishikado Y, Kitase Y, Ito S, Muramatsu H, Sato Y, Kato T, Natsume J, Kojima S.

    Nagoya J Med Sci   Vol. 78 ( 4 ) page: 359-368   2016.11

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    Language:English   Publishing type:Research paper (scientific journal)  

  42. Feasibility and safety of transseptal puncture procedures for radiofrequency catheter ablation in small children weighing below 30 kg: single-center experience Reviewed

    Yoshida S, Suzuki T, Yoshida Y, Watanabe S, Nakamura K, Sasaki T, Kawasaki Y, Ehara E, Murakami Y, Kato T, Nakamura Y.

    Europace   Vol. 2016 ( 18 ) page: 1581-1586   2016.10

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  43. 病理組織診断でリウマチ熱による伝導路障害が死因であると疑われた1例 Reviewed

    池田麻衣子,小沢広明,永田佳敬,馬場礼三,加藤太一,長井典子.

    日小児循環器会誌   Vol. 2016 ( 32 ) page: 423-428   2016.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1016/j.echo.2016.03.017. Epub 2016 Jun 7.

  44. Abnormal urinalysis on day 7 in patients with IgA vasculitis (Henoch-Schonlein purpura) Reviewed

    Kawashima N, Kawada J, Nishikado Y, Kitase Y, Ito S, Muramatsu H, Sato Y, Kato T, Natsume J, Kojima S.

    Nagoya J Med Sci   Vol. 2016 ( 78 ) page: 359-367   2016

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    Language:English   Publishing type:Research paper (scientific journal)  

  45. 門脈体循環シャントによる肺高血圧症及び肺内シャントを合併したNoonan症候群の1例 Reviewed

    永田佳敬,加藤太一,牧田智,池田麻衣子,深澤佳絵,岸本泰明,沼口敦,長井典子

    日小児循環器会誌   Vol. 31 ( 4 ) page: 212-219   2015

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  46. Macitentan reverses early obstructive pulmonary vasculopathy in rats: Early intervention in overcoming the survivin-mediated resistance to apoptosis. Reviewed

    Shinohara T, Sawada H, Otsuki S, Yodoya N, Kato T, Ohashi H, Zhang E, Saitoh S, Shimpo H, Maruyama K, Komada Y, Mitani Y.

      Vol. 308 ( 6 ) page: L523-538   2015

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  47. Potential contribution of phenotypically modulated smooth muscle cells and related inflammation in the development of experimental obstructive pulmonary vasculopathy in rats. Reviewed

    Otsuki S, Sawada H, Yodoya N, Shinohara T, Kato T, Ohashi H, Zhang E, Imanaka-Yoshida K, Shimpo H, Maruyama K, Komada Y, Mitani Y.

    PLOS ONE     2015

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi:10.1371/journal.pone.0118655.

  48. 左室心筋緻密化障害および肥大型心筋症様の所見を示したのちhistiocytoid cardiomyopathyと病理診断されたミトコンドリア病の一例 Reviewed

    鬼頭 真知子、長井 典子、小沢 広明、加藤 太一 、馬場 礼三

    日小児循環器会誌   Vol. 30 ( 2 ) page: 205-214   2014

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  49. Lack of CD4(+)CD25 (+)FOXP3 (+) regulatory T cells is associated with resistance to intravenous immunoglobulin therapy in patients with Kawasaki disease. Reviewed

    Hirabayashi Y, Takahashi Y, Xu Y, Akane K, Villalobos IB, Okuno Y, Hasegawa S, Muramatsu H, Hama A, Kato T, Kojima S.

    EUROPEAN JOURNAL OF PEDIATRICS   Vol. 172 ( 6 ) page: 231-237   2013

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  50. Central venous pressure in mechanically ventilated neonates correlates with the diameter of the inferior vena cava. Reviewed

    Sato Y, Kawataki M, Hirakawa A, Toyoshima K, Kato T, Itani Y, Hayakawa M.

    ACTA PAEDIATRICA   Vol. 102 ( 6 ) page: e241-246   2013

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  51. Coronary arterial ectasia in a 2-year-old boy showing two symptoms of Kawasaki disease without manifesting fever. Reviewed

    Kato T, Numaguchi A, Ando H, Yasui M,Kishimoto Y, Yasuda K, Fukumi D, Yasuda T.

    RHEUMATOLOGY INTERNATIONAL   Vol. 32   page: 1101-3   2012

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  52. Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract. Reviewed

    Dong SJ, Furutani Y, Suto Y, Furutani M, Zhu Y, Yoneyama M, Kato T, Itabe H, Nishikawa T, Tomimatsu H, Tanaka T, Kasanuki H, Masaki T, Kiyama R, Matsuoka R.

    MICROBIOLOGICAL RESEARCH   Vol. 167   page: 231-237   2012

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  53. Elevated levels of aldosterone in the amniotic fluid was observed in two cases of congenital mesoblastic nephroma Reviewed

    Tomomi Kotani, Seiji Sumigama, Hiromi Hayakawa, Yukio Mano, Hiroyuki Tsuda,Chisato Sugiyama, Fumitaka Kawachi, Masae Hironaka, Taichi Kato, Kenitiro Kaneko, Masahiro Hayakawa, Fumitaka Kikkawa

    ULTRASOUND IN OBSTETRICS & GYNECOLOGY   Vol. 36 ( 2 ) page: 256-258   2010.8

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Books 11

  1. 川崎病学改訂第2版

    加藤太一( Role: Contributor ,  心疾患・冠動脈疾患の鑑別)

    診断と治療社  2021.12 

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    Total pages:4   Responsible for pages:115-118   Language:Japanese Book type:Textbook, survey, introduction

  2. 発達段階からみた小児看護過程第4版

    加藤太一( Role: Contributor ,  心室中隔欠損症)

    医学書院  2021.10 

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    Total pages:4   Responsible for pages:197-200   Language:Japanese Book type:Textbook, survey, introduction

  3. 今日の小児治療指針第17版

    ( Role: Contributor)

    医学書院  2020 

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    Language:Japanese Book type:Scholarly book

  4. 川崎病診断の手引きガイドブック

    ( Role: Contributor)

    診断と治療社  2020 

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    Language:Japanese Book type:Scholarly book

  5. 川崎病学

    日本川崎病学会編集( Role: Contributor)

    診断と治療社  2018.11 

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    Language:Japanese Book type:Scholarly book

  6. 小児・成育循環器学

    日本小児循環器学会編( Role: Contributor)

    診断と治療社  2018.7 

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    Language:Japanese Book type:Scholarly book

  7. 学校心臓検診実践マニュアルQ&A

    ( Role: Contributor)

    診断と治療社  2018 

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    Language:Japanese

  8. 発達段階からみた小児看護過程

    加藤太一( Role: Sole author)

    医学書院  2008 

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    Language:Japanese

  9. Cardiovascular Development and Congenital Malformations-Molecular and Genetic Mechanisms-

    Mitsuhiro Kamisago, Kayoko Hirayama-Yamada, Taichi Kato,Shinichiro Imamura, Kunitaka Joo, Masahiko Ando, Atsuyoshi Takao, Kazuo Momma, Makoto Nakazawa, Rumiko Matsuoka( Role: Joint author)

    Blackwell Futura  2005 

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    Language:English

    Missense mutations in the PTPN11 as a cause of cardiac defects associated with Noonan syndrome.

  10. Annual Review循環器2003

    加藤太一、松岡留美子( Role: Joint author ,  Noonan症候群の遺伝子解析)

    中外医学社  2003 

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    Total pages:5   Responsible for pages:99-103   Language:Japanese Book type:Scholarly book

  11. 小児科診療マニュアル

    加藤太一( Role: Sole author)

    名古屋大学出版会  2002 

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    Language:Japanese

▼display all

MISC 1

  1. 先天性心疾患の手術非介入で経過している 18 トリソミーの検討 Reviewed

    今井 祐喜, 加藤 太一, 加藤 有一, 久保田 哲夫, 服部 哲夫

    日小児循環器会誌   Vol. 33 ( 4 ) page: 312-317   2017

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Presentations 51

  1. Analysis of the Long-term Clinical Course and the Factors Associated with Coronary Arterial Aneurysm Regression in Kawasaki Disease Patients. International conference

    Kato T, Kobayashi T, Ayusawa M, Fukazawa R, Fuse S, Hirono K, Mitani Y, Suda K, Maeda J, Miura M.

    The 13th International Kawasaki Disease Symposium  2021.10.31  International Kawasaki Disease Symposium

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    Event date: 2021.10

    Language:English   Presentation type:Symposium, workshop panel (public)  

  2. Screening by Electrocardiogram (Japan Experience) Invited International conference

    Kato T

    The 1st Multidisciplinary and Collaborative Approach on Pulmonary Artery Hypertension: International Summer Course Program  2021.9.28  Department Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada

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    Event date: 2021.9 - 2021.10

    Language:English   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Indonesia  

  3. Understanding the Pathophysiology of Idiopathic Pulmonary Arterial Hypertension Invited International conference

    Kato T

    The 16th Japan-China-Korea Pediatric Heart Forum  2021.7.11 

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    Event date: 2021.7

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:奈良  

  4. Williams症候群の遺伝医学 Invited

    加藤太一

    日本小児循環器学会第12回教育セミナーアドバンスコース  2021.2.7  日本小児循環器学会

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    Event date: 2021.2

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:オンライン  

  5. ABL1変異は先天性心疾患を伴う症候群の原因となる~エクソーム解析と質量分析法を応用した遺伝性心室中隔欠損症の網羅的病態解明~

    山本 英範, 早野 聡, 奥野 友介, 小野田 淳人, 加藤 耕治, 長井 典子, 深澤 佳絵, 齋藤 伸治, 高橋 義行, 加藤 太一

    第56回日本小児循環器学会  2020.11.22  日本小児循環器学会

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    Event date: 2020.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都  

  6. 小児3群肺高血圧症に対する治療内容と効果の検討

    加藤太一、深澤佳絵、山本英範、沼口敦、伊藤美春、齊藤明子、佐藤義朗、内田広夫、 早川昌弘

    第56回日本小児循環器学会  2020.11.22 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

  7. Analysis of the factors associated with coronary arterial aneurysm regression in patients with Kawasaki disease. International conference

    Kato T, Kobayashi T, Ayusawa M, Fukazawa R, Fuse S, Hirono K, Mitani Y, Suda K, Maeda J, Miura M

    American Heart Association Scientific Sessions 2019.  2019.11.16 

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    Event date: 2019.11

    Language:English   Presentation type:Poster presentation  

  8. 新生児領域での肺高血圧症に対する肺血管拡張薬治療の実際

    加藤太一

    第63回日本新生児成育医学会学術集会  2018.11.22 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  9. 内径のZ scoreによる冠動脈瘤退縮の解析 ~ZSP2 study サブ解析~

    加藤太一、小林徹、鮎沢衛、深澤隆治、布施茂登、廣野恵一、三谷義英、須田憲治、前田潤,三浦大

    第38回日本川崎病学会・学術集会  2018.10.16 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

  10. 冠動脈病変合併リスクの高い川崎病患者に対する投与期間を短縮させた免疫グロブリン・ステロイド初期併用療法の検討

    加藤太一, 深澤佳絵, 山本英範, 沼口敦, 早野聡, 岸本泰明, 長井典子, 梶田光春, 足達武憲, 原紳也, 安藤昌彦, 高橋義行

    第38回日本川崎病学会・学術集会  2018.10.17 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

  11. The Efficacy of Immunoglobulin plus Decreased Duration of Prednisolone for Kawasaki Disease Patients with High Risk for Coronary Abnormalities International conference

    Kato T, Fukawasa Y, Hayano S, Yamamoto H, Numaguchi A, Kishimoto Y, Nagai N, Ando M, Takahashi Y

    The 12th International Kawasaki Disease Symposium  2018.6.12 

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    Event date: 2018.6

    Language:English   Presentation type:Oral presentation (general)  

  12. ZC4H2の機能喪失はEMD発現調節を介して徐脈性不整脈を呈する

    山本英範、宮井俊輔、郷清貴、森本美仁、深澤佳絵、倉橋浩樹、加藤太一

    第67回日本人類遺伝学会  2022.12.16  日本人類遺伝学会

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜  

  13. 川崎病の急性期治療を改めて考える

    加藤太一

    第10回広島川崎病フォーラム  2022.9.2  広島川崎病フォーラム

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:オンライン  

  14. 川崎病診療の今:救急医療にも役立つ最近の知識 Invited

    加藤太一

    第35回日本小児救急医学会  2022.7.31  日本小児救急医学会

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    Event date: 2022.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京  

  15. 肺高血圧診療における成人診療科への移行 Invited

    加藤太一、足立史郎

    第58回日本小児循環器学会  2022.7.21  日本小児循環器学会

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    Event date: 2022.7

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:札幌  

  16. 長期生存し肺移植を行った非典型ACD/MPVの一例長期生存し肺移植を行った非典型ACD/MPVの一例

    齊藤明子、脇田浩正、郷清貴、森本美仁、山本英範、伊藤美春、村松友佳子、深澤佳絵、佐藤義朗、加藤太一、高橋義行、早川昌弘、安田和志、伊藤諒一

    第125回日本小児科学会  2022.4.15  日本小児科学会

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    Event date: 2022.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:郡山  

  17. 愛知県における学校心臓検診二次検診対象者抽出精度管理の取り組み

    加藤太一、平光伸也、西脇毅、長嶋正實

    第25回日本小児心電学会学術集会  2021.11.27  日本小児心電学会

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    Event date: 2021.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:オンライン  

  18. Analysis of Causative Gene by Whole Exome Sequence in Familial Congenital Heart Disease Invited

    2021.7.9 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  19. 巨大気腫性嚢胞切除が有効であった慢性肺疾患、肺高血圧の1例

    郷清貴、森本美仁、山本英範、深澤佳絵、加藤太一、兵藤玲奈、鈴木俊彦、佐藤義朗、早川昌弘、横田一樹、内田広夫

    第6回日本肺高血圧・肺循環学会学術集会  2021.5.6  第6回日本肺高血圧・肺循環学会学術集会

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    Event date: 2021.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  20. ステロイドの投与期間を短縮した初期併用療法における追加治療を要した症例の検討

    加藤太一, 深澤佳絵, 山本英範, 森本美仁, 沼口敦, 早野聡, 平林優, 岸本泰明, 長井典子, 梶田光春, 足達武憲, 原紳也, 安藤昌彦, 高橋義行

    第40回日本川崎病学会  2020.10.30 

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    Event date: 2020.10

    Language:Japanese   Presentation type:Oral presentation (general)  

  21. 新生児慢性肺疾患に合併する肺高血圧症に対する治療の検討

    加藤太一、森本美仁、山本英範、深澤佳絵、沼口敦、伊藤美春、齊藤明子、佐藤義朗、 早川昌弘

    第5回日本肺高血圧・肺循環学会  2020.9 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  22. Analysis of the factors associated with coronary arterial aneurysm regression in patients with Kawasaki disease. International conference

    Kato T, Kobayashi T, Ayusawa M, Fukazawa R, Fuse S, Hirono K, Mitani Y, Suda K, Maeda J, Miura M.

    American Heart Association Scientific Sessions 2019.  2019.11.16 

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    Event date: 2019.11

    Language:English   Presentation type:Poster presentation  

  23. ステロイド投与期間を短縮した免疫グロブリン・プレドニゾロン初期併用療法の多施設共同ランダム化比較試験による検討

    加藤太一, 深澤佳絵, 山本英範, 沼口敦, 早野聡, 平林優, 徐銀燕, 岸本泰明, 長井典子, 梶田光春, 足達武憲, 原紳也, 安藤昌彦, 高橋義行

    第39回日本川崎病学会・学術集会  2019.10.25 

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    Event date: 2019.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  24. 川崎病における冠動脈瘤内径のZ scoreに基づいた退縮の解析 ~ZSP2 study サブ解析~

    加藤太一, 小林徹, 鮎澤衛, 深澤隆治, 布施茂登, 廣野恵一, 三谷義英, 須田憲治, 前田潤, 三浦大

    第55回日本小児循環器学会  2019.6.28 

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    Event date: 2019.6

    Language:Japanese   Presentation type:Oral presentation (general)  

  25. 乳児肺高血圧症に対する高用量エポプロステノールの経験

    加藤太一, 深澤佳絵, 山本英範, 沼口敦, 脇田浩正, 伊藤美春, 齊藤明子, 佐藤義朗, 早川昌弘

    第4回日本肺高血圧・肺循環学会  2019.6.21 

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    Event date: 2019.6

    Language:Japanese   Presentation type:Oral presentation (general)  

  26. 乳児肺高血圧症に対する高用量エポプロステノールの経験

    加藤太一、深澤佳絵、山本英範、沼口敦、脇田浩正、伊藤美春、齊藤明子、佐藤義朗、早川昌弘

    第4回日本肺高血圧・肺循環学会  2019.6.21 

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    Event date: 2019.6

    Language:Japanese   Presentation type:Oral presentation (general)  

  27. 冠動脈病変合併リスクの高い川崎病患者に対する投与期間を短縮した免疫グロブリン・プレドニゾロン初期併用療法:多施設共同ランダム化比較試験による検証

    加藤 太一, 深澤 佳絵, 山本 英範, 沼口 敦, 早野 聡, 岸本 泰明, 長井 典子, 安藤 昌彦, 高橋 義行

    第54回日本小児循環器学会総会・学術集会  2018.7.7 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Poster presentation  

  28. 冠動脈病変合併リスクの高い川崎病患者に対する投与期間を短縮した免疫グロブリン・プレドニゾロン初期併用療法:多施設共同ランダム化比較試験による検証

    加藤 太一, 深澤 佳絵, 山本 英範, 沼口 敦, 早野 聡, 岸本 泰明, 長井 典子, 安藤 昌彦, 高橋 義行

    第54回日本小児循環器学会総会・学術集会  2018.7.7 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Poster presentation  

  29. 新生児慢性肺疾患に合併する肺高血圧症に対する多剤併用療法

    加藤太一, 深澤佳絵, 山本英範, 沼口敦, 伊藤美春, 齊藤明子, 佐藤義朗, 早川昌弘

    第3回日本肺高血圧・肺循環学会学術集会  2018.6.23 

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    Event date: 2018.6

    Language:Japanese   Presentation type:Oral presentation (general)  

  30. 新生児慢性肺疾患に合併する肺高血圧症に対する多剤併用療法

    加藤太一,深澤佳絵,山本英範,沼口敦,伊藤美春,齊藤明子,佐藤義朗,早川昌弘

    第3回日本肺高血圧・肺循環学会学術集会  2018.6.23 

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    Event date: 2018.6

    Language:Japanese   Presentation type:Oral presentation (general)  

  31. 川崎病患者における冠動脈描出と内径計測時の注意点 Invited

    加藤 太一

    日本心エコー図学会第29回学術集会  2018.4.28 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  32. 愛知県における学校心臓検診の心電図精度管理

    加藤 太一

    第50回若年者心疾患・生活習慣病対策協議会総会  2018.2.4 

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    Event date: 2018.2

    Language:Japanese   Presentation type:Oral presentation (general)  

  33. 愛知県における学校心臓検診の心電図精度管理

    加藤 太一

    第50回若年者心疾患・生活習慣病対策協議会総会  2018.2.4 

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    Event date: 2018.2

    Language:Japanese   Presentation type:Oral presentation (general)  

  34. マウス肺高血圧モデルにおいて骨髄由来細胞は秒変形性に関与し、ボセンタンは骨髄由来細胞のhoming促進と炎症抑制によって病変のリモデリングを制御する。

    加藤太一,三谷義英,澤田博文,大橋啓之,池山夕起子,出口隆生,桝屋正浩,丸山淳子, 丸山一男,新保秀人,駒田美弘

    第48回日本小児循環器学会  

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    Event date: 2012.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  35. Risk stratification for unresponsiveness to retreatment with intravenous immunoglobulin in patients with Kawasaki disease. International conference

    Kato T, Kishimoto Y, Tokunaga H, Ushida H, Shinohara O, Sugiyama Y, Hasegawa M, Numaguchi A, Fukasawa Y, Baba R

    The 10th International Kawasaki Disease Symposium 

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    Event date: 2012.2

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  36. マウス肺高血圧血管病変における骨髄由来幹細胞の関与とボセンタンの作用

    加藤太一,三谷義英,澤田博文,大橋啓之,池山夕起子,出口隆生,桝屋正浩,丸山淳子, 丸山一男,新保秀人,駒田美弘

    第47回日本小児循環器学会 

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    Event date: 2011.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  37. Contribution of bone marrow stem cells to the pathogenesis of pulmonary hypertension and pharmacological modulation of bone marrow-derived cells as a therapeutic target. International conference

    The 3rd Congress of Asia-Pacific Pediatric Cardiac Society 

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    Event date: 2010.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  38. Bosentan promotes incorporation of bone marrow-derived endothelial cells but inhibits infiltration of macrophages into pulmonary vascular lesions in mice exposed to chronic hypoxia: A novel concept of bosentan therapy in pulmonary hypertension International conference

    American Heart Association Scientific Sessions 2009 

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    Event date: 2009.11

    Language:English   Presentation type:Poster presentation  

  39. Role of bone marrow stem cells in the pathogenesis of pulmonary hypertension and pharmacological modulation International conference

    10th International Symposium on Mechanisms of Vasodilatation 

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    Event date: 2009.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  40. Bosentan Promotes Incorporation of Bone Marrow-Derived Endothelial Progenitor Cells but Inhibits Infiltration of Macrophages in Mice Exposed to Chronic Hypoxia.

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    Event date: 2009.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  41. Chronic Hypoxia Increases Bone Marrow-Derived Endothelial Cells of Non-Hematopoietic Stem Cell Origin, as Well as Macrophages of Hematopoietic Stem Cell Origin, in Pulmonary Vascular Legions in Mice: Differential Roles of Bone Marrow-Derived Hematopoietc and Non-Hematopoietic Stem Cells in Pulmonary Hypertension International conference

    American Heart Association Scientific Sessions 2008 

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    Event date: 2008.11

    Language:English   Presentation type:Poster presentation  

  42. 骨髄由来細胞と造血幹細胞のマウス実験的肺高血圧への関与

    加藤太一,澤田博文,池山夕起子 ,出口隆生 ,桝屋正浩,丸山淳子,丸山一男,新保秀人,駒田美弘,三谷義英

    第43回日本小児循環器学会 

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    Event date: 2007.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  43. 心臓原発横紋筋肉主の1例 -再発のモニタリングにおける問題点-

    加藤太一、谷ヶ崎博、大橋直樹、秋田利明、上田裕一、小島勢二

    第42回日本小児循環器学会 

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    Event date: 2006.7

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  44. 原発性肺高血圧症に対しsildenafil投与を行い改善が得られた3例の検討

    加藤太一、久保田勤也、西川浩、松島正氣、中山智孝、佐地勉

    第41回日本小児循環器学会 

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    Event date: 2005.7

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  45. 動脈管依存性心疾患に対するPGE1-CD製剤の投与量の検討

    加藤太一、牛田肇、西川浩、松島正氣、櫻井寛久、河村朱美、長谷川広樹、加藤紀之、櫻井一、秋田利明

    第40回日本小児循環器学会 

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    Event date: 2004.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  46. ファロー四徴症根治術後のVT症例に対する心拍変動解析

    加藤太一、安田東始哲、長嶋正實、中澤誠

    第38回日本小児循環器学会 

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    Event date: 2002.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  47. Phenotype analysis of deletion 22q11.2 syndrome patients with GPIb-β hemizygosity. International conference

    The 23rd International Congress of Pediatrics 

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    Event date: 2001.9

    Language:English   Presentation type:Oral presentation (general)  

  48. Thrombocytopenia and platelet dysfunction in del22q11.2 syndrome.

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    Event date: 2001.3

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  49. 乳児型多嚢胞腎の同胞例

    加藤太一,鬼頭修,深見英子,佐々木順子,三村俊二,早川昌弘

    第42回日本未熟児新生児学会 

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    Event date: 1997.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  50. 同種骨髄移植を施行した高IgM症候群

    加藤太一、小島勢二、谷ケ崎博、稲葉淳、加藤剛二、松山孝治、柘植郁哉

    第39回日本小児血液学会 

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    Event date: 1997.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  51. 二次性腫瘍を発症した小児癌の5例

    加藤太一,松山孝治,小島勢二,加藤剛二,近藤勝

    第12回日本小児がん学会 

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    Event date: 1996.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

▼display all

Research Project for Joint Research, Competitive Funding, etc. 4

  1. 川崎病冠動脈瘤発症予防のための急性期治療難治例予測診断法開発に直結するエビデンス創出研究

    Grant number:20314888  2020.4 - 2024.3

    難治性疾患実用化研究事業  

    加藤太一

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  2. バイオマーカーを用いた川崎病急性期治療法選択に関する研究

    2017.4 - 2020.3

    国立研究開発法人日本医療研究開発機構難治性疾患実用化研究事業 

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    Grant type:Competitive

  3. 炎症性動脈瘤形成症候群の治療法選択に関する研究

    2017.4 - 2018.3

    科学技術振興調整費 

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    Grant type:Competitive

  4. 重症川崎病患者に対する免疫グロブリンと免疫グロブリン・プレドニゾロン初期併用投与のランダム化比較試験

    2010.4 - 2011.3

    科学技術振興調整費 

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    Grant type:Competitive

    重症川崎病患者に対する免疫グロブリン・プレドニゾロン初期併用療法の効果を多施設共同無作為化比較試験で検討するための臨床試験

KAKENHI (Grants-in-Aid for Scientific Research) 9

  1. 網羅的プロテオーム解析に基づいた肺高血圧症病変における新規治療ターゲットの検証

    Grant number:23K07329  2023.4 - 2026.3

    科学研究費助成事業  基盤研究(C)

    加藤 太一, 佐藤 義朗, 山本 英範

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    Authorship:Principal investigator 

    Grant amount:\3770000 ( Direct Cost: \2900000 、 Indirect Cost:\870000 )

    肺高血圧症は、肺動脈が進行性に狭窄、閉塞する難治性疾患であり、重篤な場合、生命予後が不良な疾患です。我々は実験的に作成した肺高血圧モデルにおいて、血管が閉塞している部分と閉塞していない部分のそれぞれから蛋白質を抽出し、プロテオーム解析という手法で、両者で異なる蛋白質すなわち閉塞に関連する蛋白質を同定しました。この研究では、その蛋白の機能を検証することで、病気のメカニズムを解明することを目的としています。

  2. メタゲノム解析とオミクス解析を用いたFontan術後蛋白漏出性胃腸症の病態解明

    Grant number:22K07912  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    郷 清貴, 加藤 太一, 山本 英範

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    Authorship:Coinvestigator(s) 

    蛋白漏出性胃腸症(Protein-Losing Enteropathy: 以下PLE)は単心室型の先天性心疾患に対する機能的修復術であるFontan手術後の患者に発症する予後不良な疾患である。しかし、その発症機序は解明されておらず、治療法も確立していない。近年、消化管疾患だけでなく、様々な疾患の発症や重症化と腸内細菌叢の関連が報告されているが、Fontan術後のPLEと腸内細菌叢の関連についての報告はない。本研究の目的は、次世代シークエンサーを用いたPLE患者に特異的な腸内細菌叢組成の探索と、便のメタボロームによる網羅的な解析により、PLEに関与する菌種、代謝物などの因子を同定することである。

  3. International Collaboration of Molecular Epidemiological Research on Pulmonary Hypertension Associated with Congenital Heart Disease International coauthorship

    Grant number:20KK0219  2020.10 - 2024.3

    Grants-in-Aid for Scientific Research  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Direct Cost: \200000 )

  4. 肺高血圧症の閉塞性病変における平滑筋細胞形質変換のプロテオームによる網羅的解析

    Grant number:20K08155  2020.4 - 2023.3

    科学研究費助成事業  基盤研究(C)

    加藤 太一, 佐藤 義朗, 山本 英範

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    肺高血圧症は、肺動脈が進行性に狭窄、閉塞する難治性疾患であり、重篤な場合、生命予後が不良な疾患です。この研究は実験的に作成した肺高血圧モデルにおいて、血管が閉塞している部分と閉塞していない部分のそれぞれから蛋白質を抽出し、プロテオーム解析という手法で、両者で異なる蛋白質すなわち閉塞に関連する蛋白質を同定し、その機能を検証することで、病気のメカニズムを解明することを目的としています。
    本研究では、ラット肺高血圧モデルにおいて、肺高血圧症の閉塞性病変における平滑筋細胞の形質変換に関与する蛋白を、レーザーマイクロダイセクション(LMD)法により閉塞性病変の組織を選択的に取得して、プロテオーム解析による網羅的探索を行うことで同定し、機能を検証することを目的としている。閉塞性病変を起こすラットSugen-低酸素モデルはVEGF受容体遮断薬のSugen5416をラットに皮下注後、0.5気圧下で3週間飼育したのちに通常気圧下で飼育することで徐々に閉塞性病変が進行する。研究代表者らの既報に従い、当初は低酸素3週間の後、通常気圧下5週時点での閉塞性病変と非閉塞病変の組織をLMD法にて得て比較する予定としていたが、閉塞性病変の比率が既報よりも少なく、時系列で病変の再検討を行った。7週齢の雄SDラットに対し、Sugen5416皮下注後3週間の低酸素と5週間(8週モデル)または10週間(13週モデル)の通常気圧下で飼育したラットを作成し、血行動態及び組織評価をした結果より、当初の8週モデルの同一個体内での閉塞病変と非閉塞病変の比較よりも、8週モデルと13週モデル間で病変を比較する方が解析に適切であると考えられた。昨年度各群6匹ずつのモデルラットを作成、血行動態評価、病理評価を行ったうえで、今年度はLMD法にて病変部位の組織の取得を行った。しかしながら、実際に得られた蛋白量は13週モデルでは十分量を取得できたが、8週モデルにおいては想定以上に少ない量しか取得できなかった。このため、組織処理の方法、蛋白抽出の方法について見直しを行った。いくつかの手法を検討し、最終的に実質臓器である肝臓を用いて、十分な蛋白量が得られたプロトコールを採用することとした。現在、改めて新しい手法で8週および13週モデルの肺各群6検体からLMD法での組織取得を行っている。
    本研究では、当初既報を元に8週モデルの同一個体内での閉塞病変と非閉塞病変の比較を行う予定であった。しかしながら、想定よりも8週モデルでの閉塞性病変が目立たなかった。そのため、モデル間の比較を最適化するための時系列を変えた病理評価が必要となり、検討の結果、8週モデルと13週モデル間で閉塞病変と非閉塞病変を比較する形がその後のレーザーマイクロダイセクションおよびプロテオーム解析に適していると判断した。また、当初予定していた組織処理および蛋白抽出のプロトコールでは8週モデルの組織からの取得蛋白量が十分ではなかったため、改めて多くの組織取得が望めるプロトコールを検討することに時間を要した。
    時系列評価によって適切な比較対象が確定し、また改変した組織処理、蛋白抽出法で十分な蛋白量が得られることが見込まれることから、現在はレーザーマイクロダイセクション法にて改めて新しいプロトコールで血管病変の取得を行っている。なお、肺血管の閉塞病変は50-200μm径のものが中心であり、プロテオーム解析に必要な蛋白量の検討のため、実質臓器(ラット肝臓)を用いて、同様のサイズのものについて何か所のダイセクションにより必要蛋白量を得られるかを検討し、その結果を踏まえて肺血管のレーザーマイクロダイセクションを行っている。8週モデルと13週モデルで各群6匹に対して組織の取得を行っており、間もなく全組織取得が終了し、プロテオーム解析に進む予定である。

  5. Exploratory research of causal genes by whole-exome sequencing in patients with familial WPW syndrome

    Grant number:19K08319  2019.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    FUKASAWA YOSHIE

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Direct Cost: \300000 )

    We conducted search for causal genes in 8 families with familial WPW syndrome by whole-exome sequencing. Only one family identified a pathogenic variant of PRKAG2 gene, already known as the causal gene of familial WPW syndrome. A missense mutation in a causal gene(gene X) of hypertrophic cardiomyopathy was confirmed in one family with WPW syndrome for more than 3 generations. There was no report of WPW syndrome caused by this gene variant, it was considered to be a novel phenotype. The causal gene couldn't detect in the other 6 families.
    We planned an experimental functional analysis to prove that the pathogenic variant of gene X presents with WPW syndrome. We planned to create a model mouse using CRISPER-Cas9 and detect supraventricullar tachycardia caused by WPW syndrome with an implantable electrocardiograph, but we couldn't realize due to equipment and financial problems.

  6. "再生”を用いた新生児/小児肺高血圧症に対する新規治療法の開発

    Grant number:19K08250  2019.4 - 2022.3

    齊藤 明子

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    Direct Cost: \300000 )

    新生児/小児の肺高血圧症(PAH)は、予後不良で難治の疾患である。
    PAHに伴う心拍出量低下や右心不全は患者のQOLを著しく低下させ、死亡率は依然として高い。
    現状では複数の薬剤を併用投与するが、その効果には限界があり、PAHの患者に見られる広範な微小血管床の喪失には無効である。
    PAHの新たな治療方策のひとつとして、再生/細胞療法が挙げられる。
    本研究では、A細胞がPAHにおいて有効であることを示し、新規治療につなげるための基礎研究を行う。

  7. Development of novel therapy for chronic lung disease associated pulmonary arterial hypertension via proliferation of pulmonary alveoli.

    Grant number:15K09687  2015.4 - 2018.3

    KATO TAICHI

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    In this study, we studied whether EGF promoted the proliferation of pulmonary alveoli and improved pulmonary hypertension using hyperoxia induced chronic lung disease rat neonate model. The time course study on the duration of hyperoxia revealed that compared to control rats, systolic right ventricular pressure (RVP) and the percentage of muscularized pulmonary vessels increased significantly in the rats after 14 days of hyperoxia challenge. Daily administration of EGF slightly decreased RVP and the percentage of muscularized pulmonary vessels and slightly improved the structure of pulmonary alveoli. Furthermore, hyperoxia decreased the expression of BMPR2, FGFR1 and MMP14 in the lung, which was not restored by EGF. These results showed chronic hyperoxia for 14 days caused chronic lung disease associated pulmonary hypertension in rat neonates. EGF administration showed only slight improvement of pulmonary hypertension and the structure of pulmonary alveoli in this model.

  8. 肺高血圧における血管周囲交感神経の血管リモデリングへの関与とエンドセリンの役割

    2012.4 - 2015.3

    科学研究費補助金  基盤研究(C)

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  9. 肺高血圧症に対する分子状水素による新規抗酸化療法の開発

    2009.4 - 2011.3

    科学研究費補助金  若手研究(B)

    加藤太一

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    ラット肺高血圧モデルにおいて分子状水素による抗酸化療法の有効性の検証と機序の解析

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Teaching Experience (On-campus) 51

  1. 臨床実習II

    2022

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    臨床実習

  2. 小児科学

    2022

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    小児循環器病学一般の総説

  3. 臨床実習I

    2022

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    先天性心疾患の血行動態シミュレーションを通じた病態考察

  4. 臨床実習II

    2021

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    臨床実習

  5. 小児科学

    2021

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    小児循環器病学一般の総説

  6. 臨床実習I

    2021

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    先天性心疾患の血行動態シミュレーションを通じた病態考察

  7. 臨床実習II

    2020

  8. 臨床実習I

    2020

  9. 小児科学

    2020

  10. 臨床実習II (医学部医学科6年生)

    2016

  11. 臨床実習I (医学部医学科5年生)

    2016

  12. 小児科学(医学部医学科4年生)

    2016

  13. 小児発達障害学 (保健学科理学療法学・作業療法学専攻3年用)

    2016

  14. 小児科学(医学部医学科4年生)

    2015

  15. 臨床実習I (医学部医学科5年生)

    2015

  16. 臨床実習II (医学部医学科6年生)

    2015

  17. 小児発達障害学 (保健学科理学療法学・作業療法学専攻3年用)

    2015

  18. 臨床実習I (医学部医学科5年生)

    2014

  19. 臨床実習II (医学部医学科6年生)

    2014

  20. 小児科学(医学部医学科4年生)

    2014

  21. 臨床実習I (医学部医学科5年生)

    2013

  22. 小児科学(医学部医学科4年生)

    2013

  23. 臨床実習II (医学部医学科6年生)

    2013

  24. 小児発達障害学 (保健学科理学療法学・作業療法学専攻3年用)

    2013

  25. 臨床実習II (医学部医学科6年生)

    2012

  26. 臨床実習I (医学部医学科5年生)

    2012

  27. 小児発達障害学 (保健学科理学療法学・作業療法学専攻3年用)

    2012

  28. 小児科学(医学部医学科4年生)

    2012

  29. 小児発達障害学 (保健学科理学療法学・作業療法学専攻3年用)

    2011

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    救急・治療および循環器疾患を担当

  30. 臨床実習II (医学部医学科6年生)

    2011

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    小児循環器疾患分野を担当

  31. 臨床実習I (医学部医学科5年生)

    2011

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    小児循環器疾患分野を担当

  32. 小児科学 (医学部医学科4年生)

    2011

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    小児循環器病学を担当

  33. 小児科学 (医学部医学科4年生)

    2010

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    小児循環器病学を担当

  34. 小児発達障害学 (保健学科理学療法学・作業療法学専攻3年用)

    2010

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    救急・治療および循環器疾患を担当

  35. 臨床実習II (医学部医学科6年生)

    2010

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    小児循環器疾患分野を担当

  36. 臨床実習I (医学部医学科5年生)

    2010

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    小児循環器疾患分野を担当

  37. 小児科学 (医学部医学科4年生)

    2009

     詳細を見る

    小児循環器病学を担当

  38. 小児発達障害学 (保健学科理学療法学・作業療法学専攻3年用)

    2009

     詳細を見る

    救急・治療および循環器疾患を担当

  39. 臨床実習II (医学部医学科6年生)

    2009

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    小児循環器疾患分野を担当

  40. 臨床実習I (医学部医学科5年生)

    2009

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    小児循環器疾患分野を担当

  41. 臨床実習I (医学部医学科5年生)

    2008

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    小児循環器疾患分野を担当

  42. 小児発達障害学 (保健学科理学療法学・作業療法学専攻3年用)

    2008

     詳細を見る

    救急・治療および循環器疾患を担当

  43. 臨床実習II (医学部医学科6年生)

    2008

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    小児循環器疾患分野を担当

  44. 小児科学 (医学部医学科4年生)

    2008

     詳細を見る

    小児循環器病学を担当

  45. 小児発達障害学 (保健学科理学療法学・作業療法学専攻3年用)

    2007

     詳細を見る

    救急・治療および循環器疾患を担当

  46. 臨床実習II (医学部医学科6年生)

    2007

     詳細を見る

    小児循環器疾患分野を担当

  47. 臨床実習I (医学部医学科5年生)

    2007

     詳細を見る

    小児循環器疾患分野を担当

  48. 小児科学 (医学部医学科4年生)

    2007

     詳細を見る

    小児循環器病学を担当

  49. 臨床実習I (医学部医学科5年生)

    2006

     詳細を見る

    小児循環器疾患分野を担当

  50. 小児発達障害学 (保健学科理学療法学・作業療法学専攻3年用)

    2006

     詳細を見る

    救急・治療および循環器疾患を担当

  51. 臨床実習II (医学部医学科6年生)

    2006

     詳細を見る

    小児循環器疾患分野を担当

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