Updated on 2023/09/26

写真a

 
YAMAMOTO Eiko
 
Organization
Graduate School of Medicine Program in Integrated Medicine Social Life Science Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Professor
Contact information
メールアドレス

Degree 1

  1. 医学博士 （ 2006.3   名古屋大学 ） 

To the head of Degree.▲

Research Interests 9

  1. Maternal and Child Health

  2. Gestational trophoblastic diseases

  3. Gestational trophoblastic diseases

  4. Postpartum depression

  5. Asia

  6. Postpartum depression

  7. Maternal and child health

  8. Global health

  9. Asia

To the head of Research Interests.▲

Research Areas 8

  1. Life Science / Obstetrics and gynecology  / Gestational trophoblastic disease

  2. Life Science / Obstetrics and gynecology  / Obstetrics and Gynecology

  3. Life Science / Hygiene and public health (non-laboratory)

  4. Life Science / Hygiene and public health (non-laboratory)

  5. Life Science / Hygiene and public health (non-laboratory)  / Global health

  6. Life Science / Obstetrics and gynecology

  7. Life Science / Hygiene and public health (non-laboratory)  / Healthcare administration

  8. Life Science / Medical management and medical sociology

▼display all

To the head of Research Areas.▲

Current Research Project and SDGs 4

  1. Prevention of choriocarcinoma in developing countries in Asia

  2. A Comparative Study on the Promotion of Gender Equality in STEM Fields of Higher Education: An International Perspective

  3. Factors associated with postpartum depression in Asian countries

  4. Menstrual hygiene management among girl students in Lao PDR

To the head of Current Research Project and SDGs.▲

Research History 7

  1. Nagoya University   Professor

    2022.8

  2. Nagoya University   Department of Healthcare Administration   Professor

    2021.10

    　 More details

    Country：Japan

  3. Nagoya University   Graduate School of Medicine Program in Integrated Medicine Social Life Science   Associate professor

    2016.4 - 2022.8

  4. Nagoya University   Department of Healthcare Administration   Associate professor

    2016.4 - 2021.9

    　 More details

    Country：Japan

  5. Nagoya University   Asia Satellite Campus Institution   Designated associate professor

    2014.10 - 2016.3

    　 More details

    Country：Japan

  6. Nagoya University   Department of Obstetrics and Gynecology   Lecturer

    2011.10 - 2014.9

    　 More details

    Country：Japan

  7. Nagoya University   Department of Obstetrics and Gynecology   Assistant Professor

    2006.4 - 2011.10

    　 More details

    Country：Japan

▼display all

To the head of Research History.▲

Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    2002.4 - 2006.3

    　 More details

    Country： Japan

  2. Tokyo Medical and Dental University   Faculty of Medicine

    1990.4 - 1996.3

    　 More details

    Country： Japan

To the head of Education.▲

Professional Memberships 12

  1. 日本産科婦人科学会   評議員

    2015.1

  2. 日本婦人科腫瘍学会

  3. Japan Association of Gestational Trophoblastic Diseases

    2008.1

  4. 日本胎盤学会   理事

    2010.1

  5. Japan Association of International Health

  6. Japan Cancer Association

  7. 日本疫学会

  8. 日本胎盤学会

  9. Japan Association of Gestational Trophoblastic Diseases

  10. 日本産科婦人科学会

  11. 日本婦人科腫瘍学会

  12. Japan Association of International Health

▼display all

To the head of Professional Memberships.▲

Committee Memberships 11

  1. Nagoya University   Gender Diversity Center  

    2022.4   

    　 More details

    Committee type：Other

  2. 名古屋大学   アジア未来創造運営グループ  

    2021.10   

  3. 名古屋大学アジアサテライトキャンパス学院   運営委員会委員  

    2021.4   

    　 More details

    Committee type：Other

  4. 日本産科婦人科学会   婦人科悪性腫瘍登録システムの運用と精度管理に関する小委員会  

    2021.4   

    　 More details

    Committee type：Academic society

  5. Nagoya University   The Nagoya University Ethics Committee (clinical research)  

    2018.4 - 2021.3   

  6. Nagoya University   The Nagoya University Ethics Committee (intervention study)  

    2018.4 - 2021.3   

  7. 日本婦人科腫瘍学会   代議員  

    2017.1   

    　 More details

    Committee type：Academic society

  8. Nagoya University   The Nagoya University Ethics Committee (clinical intervention study)  

    2016.4 - 2018.3   

  9. 日本胎盤学会   評議員  

    2016.1   

    　 More details

    Committee type：Academic society

  10. 名古屋大学   ヤングリーダーズプログラム運営委員会委員  

    2014.10   

  11. 日本絨毛性疾患研究会   代表幹事  

    2010.4   

    　 More details

    Committee type：Academic society

▼display all

To the head of Committee Memberships.▲

Awards 3

  1. The Y.W. Loke Young Investigator Travel Award

    2005.9   International Federation of Placenta Association 2005  

  2. 相馬賞

    2007.11   日本胎盤学会  

    　More details

    Country：Japan

    最優秀演題賞

  3. The Y.W. Loke Young Investigator Travel Award

    2008.9   International Federation of Placenta Association 2008  

To the head of Awards.▲
 

Papers 243

  1. *N-acetylglucosaminyltransferase V Regulates Extravillous Trophoblast Invasion through Glycosylation of alfa5beta1 integrin Reviewed

    Yamamoto E, Ino K, Miyoshi E, Inamori KI, Abe A, Sumigama S, Iwase A, Kajiyama H, Shibata K, Nawa A, Kikkawa F.

    Endocrinology   Vol. 150 ( 2 ) page： 990-999   2009

    　More details

    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    For successful human placentation, invasion of trophoblast cells into the uterus and its associated vasculature is essential, and the regulation of this process is controlled by many factors at the fetal-maternal interface. N-acetylglucosaminyltransferase V (GnT-V) is a key enzyme that catalyzes beta1, 6-N-acetylglucosamine (beta1-6GlcNAc) branching on asparagine-linked oligosaccharides of cell proteins. GnT-V and its product, beta1-6GlcNAc, are known to regulate cellular transformation and correlate with the metastatic potential of various cancer cells. The aim of the present study was to determine whether extravillous trophoblast (EVT) expressed this molecule and examine the role of GnT-V in the regulation of human trophoblast invasion. Immunohistochemistry showed that GnT-V was strongly expressed within the cytoplasm of EVT in the anchoring villi; this expression was down-regulated in EVTs invading the decidua. Suppression of beta1-6GlcNAc glycosylation by swainsonine enhanced the migratory potential and invasive capability of both primary EVTs and the EVT cell line, HTR-8/SVneo. Down-regulation of GnT-V expression by small interfering RNA in the choriocarcinoma cell line Jar consistently enhanced the migration and invasive capacity of these cells and elevated cellular adhesion to extracellular matrix proteins, such as fibronectin and collagen type I/IV. The extent of beta1-6 branching of alpha5beta1 integrin was significantly reduced in small interfering GnT-V-transfected Jar cells compared with mock transfectants, although the expression of alpha1, alpha5, alpha6, and beta1 integrin on the cell surface was not changed. These results suggest that GnT-V is expressed in human EVT and is involved in regulating trophoblast invasion through modifications of the oligosaccharide chains of alpha5beta1 integrin.

  2. *Ikaros is expressed in human extravillous trophoblasts and involved in their migration and invasion.

    Yamamoto E, Ito T, Abe A, Sido F, Ino K, Itakura A, Mizutani S, Dovat S, Nomura S, Kikkawa F.

    Molecular Human Reproduction   Vol. 11 ( 11 ) page： 825   2005.11

    　More details

    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    The transcriptional factor Ikaros was originally found to function as a key regulator of lymphocyte differentiation. In addition, we have reported that Ikaros regulates the human placental leucine aminopeptidase (P-LAP)/insulin-regulated aminopeptidase (IRAP) gene in choriocarcinoma trophoblastic cells, suggesting that Ikaros might be involved in placental development, while even its presence in human placenta remains undetermined. We therefore sought to clarify the location and roles of Ikaros in human placenta. Immunohistochemical analysis showed modest Ikaris expression in syncytium, and intense expression in extravillous trophoblasts (EVTs) in first trimester placenta. Western blot analysis showed that villous trophoblasts principally expressed Ikaros-2/3, while Ikaros-x (Ikx) was predominantly expressed in cultured EVTs. Furthermore, to investigate the functional role of Ikx in EVTs, the EVT cell line HTR-8/SVneo was infected with a retrovirus vector expressing the hemagglutinin (HA)-tagged dominant negative isoform Ikaros-6 (Ik6), which prevents the DNA-binding activity of Ikx. Antibody against HA showed successful transduction of Ik6 in HTR-8/SVneo cells on immunocytochemistry and Western blotting. Transduction of Ik6 significantly reduced the migratory and invasive abilities of HTR-8/SVneo cells. These results suggest that Ikx is involved in migration and invasion of EVTs in early placentation.

  3. *Expression of N-acetylglucosaminyltransferase V in Endometrial Cancer Correlates with Poor Prognosis Reviewed

    Yamamoto E, Ino K, Miyoshi E, Shibata K, Takahashi N, Kajiyama H, Nawa A, Nomura S, Nagasaka T, Kikkawa F

    British Journal of Cancer   Vol. 97 ( 11 ) page： 1538-1544   2007.12

    　More details

    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    N-acetylglucosaminyltransferase V (GnT-V) is an enzyme that catalyses beta1-6 branching of N-acetylglucosamine on asparagine-linked oligosaccharides of cell proteins. The present study aimed to investigate GnT-V expression and its prognostic significance in endometrial cancer. N-acetylglucosaminyltransferase V expression was studied by immunohistochemistry in 74 surgically resected endometrial cancers, and the staining intensity was evaluated. High GnT-V expression in tumour cells was found in 43 (58.1%) of the 74 cases, and was positively correlated with advanced patient age, histological grade, and lymph vascular space involvement. Patients with high GnT-V expression had significantly impaired overall survival and progression-free survival (PFS) (P=0.0041 and P=0.0023, respectively) compared to patients with low expression of GnT-V. On multivariate analysis, GnT-V expression was an independent prognostic factor for PFS (P=0.0364). beta1-6 branching of asparagine-linked oligosaccharides was also detected in GnT-V-positive endometrial cancer cells by leukoagglutinating phytohaemagglutinin (L(4)-PHA) staining, and the molecular size of the major glycoproteins recognised by L(4)-PHA was approximately 60-200 kDa by lectin blot analysis. These results suggested that high GnT-V expression was correlated with an unfavourable clinical outcome, and that GnT-V is involved in the malignant potential of endometrial cancer by increasing the synthesis of beta1-6 branching of asparagine-linked oligosaccharides.

  4. *A pure nongestational choriocarcinoma of the ovary diagnosed with short tandem repeat analysis: case report and review of the literature. Reviewed

    Yamamoto E, Ino K, Yamamoto T, Sumigama S, Nawa A, Nomura S, Kikkawa F.

    International Journal of Gynecologic Cancer   Vol. 17 ( 1 ) page： 254-8   2007.1

    　More details

    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    Nongestational pure choriocarcinoma of the ovary is a very rare germ cell tumor. Except in women before menarche, determination of the origin is very difficult without genetic analysis. We present a pure nongestational choriocarcinoma arising in the left ovary of a 19-year-old woman. Following surgery, pathologic findings of the tumor demonstrated pure choriocarcinoma without combination of other germ cell tumor elements. We confirmed its nongestational origin by DNA polymorphism analysis at 15 short tandem repeat loci. Multiple courses of chemotherapy with methotrexate, etoposide, and actinomycin-D were effective for this case. DNA polymorphism analysis is useful to determine genetic origin in pure choriocarcinoma of the ovary.

  5. Activator protein-2 impairs the invasion of a human extravillous trophoblast cell line. Reviewed

    Kotani Tomomi, Iwase Akira, Ino Kazuhiko, Sumigama Seiji, Yamamoto Eiko, Hayakawa Hiromi, Nagasaka Toshiro, Itakura Atsuo, Nomura Seiji, Kikkawa Fumitaka.

    Endocrinology   Vol. 150 ( 9 ) page： 4376-4385   2009.11

    　More details

    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    The reduced migration/invasion of extravillous trophoblasts (EVTs) is a key feature of the genesis of preeclampsia. We and others previously reported that transcriptional factors activator protein-2 (AP-2) alpha and AP-2gamma act as suppressors of tumor invasion. The present study examined the expressions of AP-2alpha and AP-2gamma in preeclamptic placenta vs. control placenta and investigated their effect on the function of EVTs. The expressions of AP-2alpha and AP-2gamma were elevated in the preeclamptic placentas in comparison with the gestational age-matched control placentas. Their expressions also increased in EVTs of the preeclamptic placentas. Thereafter, we transfected AP-2alpha or AP-2gamma into human EVT cell line, HTR-8/SVneo. The overexpression of AP-2alpha or AP-2gamma decreased the migratory and invasive abilities in HTR-8/SVneo cells. This was followed by the reduction of protease activated receptor-1 and matrix metalloproteinases and a significant induction of plasminogen activator inhibitor-1 and the tissue inhibitor of metalloproteinase-1. AP-2alpha and AP-2gamma were weakly expressed in the cultured EVTs and HTR-8/SVneo cells, whereas they were induced by TNF-alpha, which increases in preeclamptic placenta and impairs trophoblast invasion. In the presence of TNF-alpha, the invasion of the HTR-8/SVneo cells was partially restored by a blocking of AP-2 induction using small interfering RNA of AP-2. The present data suggest that AP-2 may suppress trophoblast migration and invasion, thus leading to a shallow placentation in preeclampsia.

  6. *High expression of N-acetylglucosaminyltransferase V in mucinous tumors of the ovary. Reviewed

    Takahashi Noriko, Yamamoto Eiko, Ino Kazuhiko, Miyoshi Eiji, Nagasaka Toshiro, Kajiyama Hiroaki, Shibata Kiyosumi, Nawa Akihiro, Kikkawa Fumitaka

    Oncology Report   Vol. 22 ( 5 ) page： 1027-1032   2009.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    N-acetylglucosaminyltransferase V (GnT-V) is an enzyme that catalyzes beta1-6 branching of N-acetylglucosamine (GlcNAc) on asparagine-linked oligosaccharides of cell proteins. The present study aimed to investigate GnT-V expression and its prognostic significance in epithelial ovarian cancer. GnT-V expression was studied by immunohistochemistry in 83 surgically resected ovarian cancers, and the staining intensity was evaluated. High GnT-V expression in cancer cells was found in 17 (20.5%) of the 83 cases, and was positively correlated with early FIGO staging. In the histological type, mucinous adenocarcinoma showed significantly strong immunostaining compared to the non-mucinous type (P<0.001). In 36 mucinous tumors, the GnT-V immunostaining score was significantly higher in cancer than in benign and borderline tumors (P<0.001). NOM-1, a human ovarian mucinous adenocarcinoma cell line, expressed strong GnT-V protein and swainsonine treatment suppressed beta1-6GlcNAc branching and reduced migration ability significantly (P<0.001). These results suggested that GnT-V might be involved in the malignant potential of mucinous ovarian cancer.

  7. Tocilizumab inhibits interleukin-6-mediated matrix metalloproteinase-2 and -9 secretions from human amnion cells in preterm premature rupture of membranes. Reviewed

    Mano Y, Shibata K, Sumigama S, Hayakawa H, Ino K, Yamamoto E, Kajiyama H, Nawa A, Kikkawa F.

    Gynecol Obstet Invest.   Vol. 68 ( 3 ) page： 145-153.   2009.7

    　More details

    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND/AIMS: In the present study, we investigated the participation of inflammatory cytokine-induced mediated matrix metalloproteinase (MMP) expressions and inhibition of interleukin (IL)-6-induced MMP secretion in amniotic epithelial cells by tocilizumab. METHODS: To investigate the role of MMP expressions, immunohistochemical staining was performed using membranes obtained from 10 patients with preterm premature rupture of membranes (PPROM) and from 10 patients who underwent a nonlabor cesarean section. We also investigated the regulation of MMP expression by inflammatory cytokines in human amnion cells. RESULTS: Immunohistochemical staining showed a significantly higher expression of MMP-2 and -9 in PPROM. Treatment of cultured WISH and primary amniotic epithelial cells with 10(-8) or 10(-7)M IL-6 or tumor necrosis factor (TNF)-alpha clearly increased the secretion of MMP-2 and -9. Treatment with 10(-8)M TNF-alpha or IL-6 significantly increased the invasion of WISH or primary amniotic epithelial cells, respectively, compared with the control. At a low concentration of 1 microg/ml, tocilizumab (anti-human IL-6 receptor monoclonal antibody) inhibited the IL-6-induced MMP secretion. CONCLUSIONS: This paper is the 1st report of tocilizumab inhibiting IL-6-induced MMP-2 and MMP-9 secretions from human amnion cells in PPROM.

  8. Fertility-sparing operation for recurrence of uterine cervical perivascular epithelioid cell tumor Reviewed

    Yamamoto E, Ino K, Sakurai M, Takigawa S, Iwase A, Kikkawa F.

    Rare Tumors     page： 72-73   2010.2

    　More details

    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  9. 肝転移巣の破裂による腹腔内出血を契機に診断された絨毛癌の１例 Reviewed

    林加奈子,　山本英子,　新美薫,　近藤紳司,　稲葉智子,　井箟一彦, 吉川史隆

    東海産科婦人科学会雑誌   Vol. 46   page： 209-212   2010.3

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

  10. 7歳女児に発症した子宮原発横紋筋肉腫の1例 Reviewed

    新美薫、山本英子、東真規子、林加奈子、近藤紳司、河合智子、井箟一彦、吉川史隆

    日本婦人科腫瘍学会雑誌   Vol. 28 ( 4 )   2010.10

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

  11. A case of complete remission of intractable gestational choriocarcinoma with subsequent chemotherapy after pembrolizumab.

    Niimi K, Yamamoto E, Oda Y, Nishiko Y, Shibata M, Nishino K, Kajiyama H

    Taiwanese journal of obstetrics & gynecology   Vol. 62 ( 5 ) page： 745 - 748   2023.9

    　More details

    Language：English  

    DOI： 10.1016/j.tjog.2023.07.019

    PubMed

  12. Increased number of live births by migrant mothers shows areal inequality in Japan: A descriptive study.

    Nishino K, Inthaphatha S, Yamamoto E

    SSM - population health   Vol. 23   page： 101447   2023.9

    　More details

    Language：English  

    DOI： 10.1016/j.ssmph.2023.101447

    PubMed

  13. Factors associated with pentavalent vaccine coverage among 12-23-month-old children in Afghanistan: A cross-sectional study

    Frozanfar Muhammad Kamel, Hamajima Nobuyuki, Fayaz Said Hafizullah, Rahimzad Abdullah Darman, Stanekzai Hedayatullah, Inthaphatha Souphalak, Nishino Kimihiro, Yamamoto Eiko

    PLOS ONE   Vol. 18 ( 8 ) page： e0289744   2023.8

    　More details

  14. 特集 絨毛性疾患の最新トピックス 胞状奇胎のトピックス 3.hCG測定の留意点と低単位hCG持続症例の取り扱い

    新美 薫, 山本 英子

    産婦人科の実際   Vol. 72 ( 2 ) page： 121 - 124   2023.2

    　More details

    Publisher：金原出版  

    DOI： 10.18888/sp.0000002455

    CiNii Research

  15. 特集 絨毛性疾患の最新トピックス 疫学のトピックス 1.絨毛性疾患の発生動向の最新知見

    山本 英子, 新美 薫, 西野 公博, 井箟 一彦

    産婦人科の実際   Vol. 72 ( 2 ) page： 109 - 114   2023.2

    　More details

    Publisher：金原出版  

    DOI： 10.18888/sp.0000002453

    CiNii Research

  16. Drug library screening identifies histone deacetylase inhibition as a novel therapeutic strategy for choriocarcinoma

    Watanabe Eri, Yokoi Akira, Yoshida Kosuke, Sugiyama Mai, Kitagawa Masami, Nishino Kimihiro, Yamamoto Eiko, Niimi Kaoru, Yamamoto Yusuke, Kajiyama Hiroaki

    CANCER MEDICINE   Vol. 12 ( 4 ) page： 4543 - 4556   2023.2

    　More details

  17. Validation of the abbreviated version of the World Health Organization Quality of Life in Mongolia: a population-based cross-sectional study among adults in Ulaanbaatar

    Bat-Erdene Enkhjin, Tumurbaatar Enkhnaran, Tumur-Ochir Gantsetseg, Jamiyandorj Otgonbold, Jadamba Tsolmon, Yamamoto Eiko, Hamajima Nobuyuki, Oka Takakazu, Lkhagvasuren Battuvshin

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 85 ( 1 ) page： 79 - 92   2023.2

    　More details

  18. Sickness absence among employees of healthcare organizations in the public sector in Mongolia: A cross-sectional study

    Sukhee Erdenetuya, Sovd Tugsdelger, Khaltar Ulzii-Orshikh, Hamajima Nobuyuki, Sereenen Enkhbold, Davaakhuu Narantuya, Yamamoto Eiko

    Journal of Occupational Health   Vol. 65 ( 1 ) page： e12390   2023.1

    　More details

    Language：English   Publisher：Japan Society for Occupational Health  

    <p><b>Objectives</b>: This study aimed to understand the rate of sickness absence (SA) among employees of public healthcare organizations in Mongolia, to identify factors associated with long-term SA, and to estimate costs due to SA.</p><p><b>Methods</b>: This cross-sectional study included employees of public healthcare organizations who had certified SA from 2016 to 2018. Sociodemographic and occupational characteristics of absentees and the data on absences were collected. A logistic regression analysis was performed to identify factors associated with long-term SA (≥15 days) among employees who had SA. Absence parameters and the average costs due to SA were calculated and the total cost due to SA at all public healthcare organizations was estimated.</p><p><b>Results</b>: From 2016 to 2018, there were 13 653 absentees and 21 043 SA, and the absence rate was 0.9%. The average absence length per absence and absentee were 9.63 days and 14.85 days, respectively. Factors associated with long-term SA were age ≥40 years, 10-19 years in employment, working at the second and tertiary levels, and night shift. The average cost per absentee was 295.5 USD, and the estimated total cost for all health organizations was 1 796 993 USD per year.</p><p><b>Conclusions</b>: The absence rate was 0.9% and older age, longer work experience, higher organizational level, and night shift were associated with taking a long-term SA. To reduce the costs of absenteeism and promote the health of employees in healthcare organizations, policymakers should review the policies related to SA and develop national guidelines on SA for employers, healthcare managers, and employees.</p>

    DOI： 10.1002/1348-9585.12390

    Web of Science

    PubMed

    CiNii Research

  19. Satisfaction With Health Care Services at the Pediatric Specialist Clinic of the National Referral Center in Malaysia: Cross-sectional Study of Caregivers' Perspectives.

    M Selvarajah T, Yamamoto E, Saw YM, Kariya T, Hamajima N

    JMIRx med   Vol. 3 ( 2 ) page： e33025   2022.5

    　More details

    Language：English  

    DOI： 10.2196/33025

    PubMed

  20. Rates and Factors Associated With Serious Outcomes of Patient Safety Incidents in Malaysia: An Observational Study.

    Khalid KH, Yamamoto E, Hamajima N, Kariya T

    Global journal on quality and safety in healthcare   Vol. 5 ( 2 ) page： 31 - 38   2022.5

    　More details

    Language：English  

    DOI： 10.36401/JQSH-21-19

    PubMed

  21. Menstrual health and factors associated with school absence among secondary school girls in Luang Prabang Province, Lao People's Democratic Republic: A cross-sectional study

    Inthaphatha Souphalak, Louangpradith Viengsakhone, Xiong Leyla Isin, Xiong Valee, Ly Ly, Xaitengcha Vue, Phengsavanh Alongkone, Hamajima Nobuyuki, Yamamoto Eiko

    PLOS ONE   Vol. 16 ( 12 ) page： e0261268   2021.12

    　More details

  22. 特集 図解　分子メカニズムから理解する婦人科がんの薬物療法 【各論】 Ⅲ　子宮体部悪性腫瘍 4.絨毛性疾患

    西野 公博, 新美 薫, 山本 英子

    産婦人科の実際   Vol. 70 ( 12 ) page： 1522 - 1528   2021.11

    　More details

    Publisher：金原出版  

    DOI： 10.18888/sp.0000001973

    CiNii Research

  23. 特集 　ヒト胎盤機能と病態 絨毛性疾患のup-date

    新美 薫, 山本 英子

    HORMONE FRONTIER IN GYNECOLOGY   Vol. 28 ( 3 ) page： 59 - 65   2021.9

    　More details

    Publisher：メディカルレビュー社  

    DOI： 10.34449/j0015.28.03_0059-0065

    CiNii Research

  24. 特集 婦人科がん機能温存治療のすべて 絨毛性疾患　妊孕性温存

    山本 英子, 新美 薫, 西野 公博

    産科と婦人科   Vol. 88 ( 7 ) page： 849 - 853   2021.7

    　More details

    Publisher：(株)診断と治療社  

    DOI： 10.34433/j00525.2021247666

    CiNii Research

  25. Rate of achievement of therapeutic outcomes and factors associated with control of non-communicable diseases in rural east Malaysia: implications for policy and practice

    Keng Zhi Yi, Saw Yu Mon, Thung Senk Chung, Chong Woon Wee, Albert Amanda, Kariya Tetsuyoshi, Yamamoto Eko, Hamajima Nobuyuki

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page： 3812   2021.2

    　More details

  26. Trends and risk factors for infant mortality in the Lao People's Democratic Republic. Reviewed International coauthorship International journal

    Viengsakhone Louangpradith, Eiko Yamamoto, Souphalak Inthaphatha, Bounfeng Phoummalaysith, Tetsuyoshi Kariya, Yu Mon Saw, Nobuyuki Hamajima

    Scientific reports   Vol. 10 ( 1 ) page： 21723 - 21723   2020.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    A high infant mortality rate (IMR) indicates a failure to meet people's healthcare needs. The IMR in Lao People's Democratic Republic has been decreasing but still remains high. This study aimed to identify the factors involved in the high IMR by analyzing data from 53,727 live births and 2189 women from the 2017 Lao Social Indicator Survey. The estimated IMR decreased from 191 per 1000 live births in 1978-1987 to 39 in 2017. The difference between the IMR and the neonatal mortality rate had declined since 1978 but did not change after 2009. Factors associated with the high IMR in all three models (forced-entry, forward-selection, and backward-selection) of multivariate logistic regression analyses were auxiliary nurses as birth attendants compared to doctors, male infants, and small birth size compared to average in all 2189 women; and 1-3 antenatal care visits compared to four visits, auxiliary nurses as birth attendants compared to doctors, male infants, postnatal baby checks, and being pregnant at the interview in 1950 women whose infants' birth size was average or large. Maternal and child healthcare and family planning should be strengthened including upgrading auxiliary nurses to mid-level nurses and improving antenatal care quality.

    DOI： 10.1038/s41598-020-78819-9

    Web of Science

    PubMed

  27. Factors associated with postpartum depression among women in Vientiane Capital, Lao People's Democratic Republic: A cross-sectional study. Reviewed International coauthorship International journal

    Souphalak Inthaphatha, Eiko Yamamoto, Viengsakhone Louangpradith, Yuki Takahashi, Alongkone Phengsavanh, Tetsuyoshi Kariya, Yu Mon Saw, Nobuyuki Hamajima

    PloS one   Vol. 15 ( 12 ) page： e0243463   2020.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Postpartum depression is a worldwide public health concern. The prevalence of postpartum depression is reported to be greater in developing countries than in developed countries. However, to the best of our knowledge, no papers on postpartum depression in the Lao People's Democratic Republic have been published. In order to strengthen maternal and child health, the current situation of postpartum depression should be understood. This study aims to determine the prevalence of postpartum depression and identify factors associated with postpartum depression in Vientiane Capital, Lao People's Democratic Republic. Study participants were 428 women 6-8 weeks postpartum who visited four central hospitals in Vientiane Capital for postnatal care from July to August 2019. Structured questionnaires were used to collect socio-demographic, obstetrical and infant, and psychiatric data about the women and their partners. The Edinburgh Postnatal Depression Scale (EPDS) was used to identify suspected cases of postpartum depression with the cut-off score of 9/10. Multivariable logistic regression was used to examine independent factors that were associated with suspected postpartum depression (EPDS ≥10). The mean age of the 428 women was 28.1 years, and the prevalence of suspected postpartum depression was 31.8%. Multivariable logistic regression using variables that were statistically significant on bivariate analyses indicated that three variables were associated with suspected postpartum depression: unintended pregnancy (AOR = 1.66, 95% CI 1.00-2.73, P = 0.049), low birth satisfaction (AOR = 1.85, 95% CI 1.00-3.43, P = 0.049), and depression during pregnancy (AOR = 3.99, 95% CI 2.35-6.77, P <0.001). In this study, unintended pregnancy, low birth satisfaction, and depression during pregnancy were independent risk factors for postpartum depression. These results suggest that the mental health of pregnant women should be monitored, and that health care services, especially family planning and supportive birth care, should be strengthened to prevent postpartum depression.

    DOI： 10.1371/journal.pone.0243463

    Web of Science

    PubMed

  28. 特集 異所性妊娠の最新診療 異所性絨毛性疾患

    新美 薫, 山本 英子, 吉川 史隆

    産科と婦人科   Vol. 87 ( 7 ) page： 829 - 834   2020.7

    　More details

    Publisher：(株)診断と治療社  

    DOI： 10.34433/j00525.2020296777

    CiNii Research

  29. The management of hydatidiform mole using prophylactic chemotherapy and hysterectomy for high-risk patients decreased the incidence of gestational trophoblastic neoplasia in Vietnam: a retrospective observational study Reviewed

    Yamamoto Eiko, Tien Dat Minh, Sekiya Yoko, Tamakoshi Koji, Xuan Phuoc Nguyen, Nishino Kimihiro, Kotani Kaoru Tomomi, Kajiyama Hiroaki, Shibata Kiyosumi, Quang Thanh Le, Kikkawa Fumitaka

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 2 ) page： 183 - 191   2020.5

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.18999/nagjms.82.2.183

    Web of Science

    PubMed

  30. 増刊号 産婦人科処方のすべて2020-症例に応じた実践マニュアル 婦人科編 Ⅳ.腫瘍 絨毛性疾患

    新美 薫, 山本 英子, 梶山 広明

    臨床婦人科産科   Vol. 74 ( 4 ) page： 215 - 218   2020.4

    　More details

    Publisher：株式会社医学書院  

    DOI： 10.11477/mf.1409210010

    CiNii Research

  31. 特集 やさしくわかる　産科婦人科検査マスターブック (第2章)婦人科腫瘍分野　絨毛性疾患のhCG

    山本 英子, 新美 薫, 西野 公博

    産科と婦人科   Vol. 87 ( 13 ) page： 168 - 171   2020.3

    　More details

    Publisher：(株)診断と治療社  

    DOI： 10.34433/j00525.2020202544

    CiNii Research

  32. Outcome of cesarean scar pregnancy treated with local methotrexate injection Reviewed International coauthorship

    Le Minh Tam, Kotani Tomomi, Tran Manh Linh, Phan Thi Minh Thu, Tran Viet Khanh, Nguyen Thi Kim Anh, Nguyen Tran Thao Nguyen, Moriyama Yoshinori, Yamamoto Eiko, Nguyen Vu Quoc Huy, Truong Quang Vinh, Cao Ngoc Thanh, Kikkawa Fumitaka

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 1 ) page： 15 - 23   2020.2

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.18999/nagjms.82.1.15

    Web of Science

    PubMed

  33. The efficacy and toxicity of 4-day chemotherapy with methotrexate, etoposide and actinomycin D in patients with choriocarcinoma and high-risk gestational trophoblastic neoplasia Reviewed

    Sato Shizuka, Yamamoto Eiko, Niimi Kaoru, Ino Kazuhiko, Nishino Kimihiro, Suzuki Shiro, Kotani Tomomi, Kajiyama Hiroaki, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 1 ) page： 203 - 209   2020.1

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10147-019-01540-9

    Web of Science

    PubMed

  34. IFPA meeting 2018 workshop report II: Abnormally invasive placenta; inflammation and infection; preeclampsia; gestational trophoblastic disease and drug delivery Invited Reviewed International coauthorship

    Albrecht Christiane, Chamley Larry, Charnock-Jones D. Stephen, Collins Sally, Fujiwara Hiroshi, Golos Thaddeus, Grayo Solene, Hannan Natalie, Harris Lynda, Ichizuka Kiyotake, Illsley Nicholas P., Iwashita Mitsutoshi, Kallol Sampada, Al-Khan Abdulla, Lash Gendie, Nagamatsu Takeshi, Nakashima Akitoshi, Niimi Kaoru, Nomoto Masataka, Redman Christopher, Saito Shigeru, Tanimura Kenji, Tomi Masatoshi, Usui Hirokazu, Vatish Manu, Wolfe Bryce, Yamamoto Eiko, O'Tierney-Ginn Perrie

    PLACENTA   Vol. 84   page： 9 - 13   2019.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.placenta.2019.02.006

    Web of Science

    PubMed

  35. Comparison of long-term oncologic outcomes between metastatic ovarian carcinoma originating from gastrointestinal organs and advanced mucinous ovarian carcinoma Reviewed

    Kajiyama Hiroaki, Suzuki Shiro, Utsumi Fumi, Yoshikawa Nobuhisa, Nishino Kimihiro, Ikeda Yoshiki, Niimi Kaoru, Yamamoto Eiko, Kawai Michiyasu, Shibata Kiyosumi, Nagasaka Tetsuro, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 24 ( 8 ) page： 950 - 956   2019.8

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10147-019-01438-6

    Web of Science

    PubMed

  36. Multiple ruptured cerebral aneurysms at the National Hospital of the Kyrgyz Republic between 2008 and 2014: a departmental summary Reviewed International coauthorship

    Yrysov Keneshbek, Tursunov Doniyorjon, Reyer Joshua A., Yamamoto Eiko, Yrysova Mirgul, Hamajima Nobuyuiki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 3 ) page： 511 - 518   2019.8

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.18999/nagjms.81.3.511

    Web of Science

    PubMed

  37. Factors associated with HIV testing among the general male population in Cambodia: A secondary data analysis of the Demographic Health Survey in 2005, 2010, and 2014 Reviewed International coauthorship

    Narin Piseth, Yamamoto Eiko, Saw Yu Mon, Net Ny, Inthaphatha Souphalak, Kariya Tetsuyoshi, Hamajima Nobuyuki

    PLOS ONE   Vol. 14 ( 7 ) page： e0219820   2019.7

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0219820

    Web of Science

    PubMed

  38. Increased LIGHT leading to sFlt-1 elevation underlies the pathogenic link between hydatidiform mole and preeclampsia Reviewed

    Iriyama Takayuki, Wang Guan, MidoriYoshikawa, Mimura Nobuko, Matsui Haruka, Sayama Seisuke, Kumasawa Keiichi, Nagamatsu Takeshi, Koga Kaori, Kotani Tomomi, Niimi Kaoru, Yamamoto Eiko, Kellems Rodney E., Xia Yang, Osuga Yutaka, Fujii Tomoyuki

    SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page： 10107   2019.7

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-019-46660-4

    Web of Science

    PubMed

  39. Cognitive function measured with the Revised Hasegawa's Dementia Scale among elderly individuals in Lao PDR Reviewed International coauthorship

    Kounnavong Sengchanh, Ratsavong Kethmany, Soundavong Khouanchay, Xayavong Syda, Kariya Tetsuyoshi, Saw Yu Mon, Yamamoto Eiko, Horibe Kentaro, Toba Kenji, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 2 ) page： 281 - 290   2019.5

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.18999/nagjms.81.2.281

    Web of Science

    PubMed

  40. Outbreak detection of influenza-like illness in Prey Veng Province, Cambodia: a community-based surveillance Reviewed International coauthorship

    Long-Hay Puthik, Yamamoto Eiko, Bun Sreng, Savuth Thai, Buntha So, Sokdaro Soy, Kariya Tetsuyoshi, Saw Yu Mon, Sengdoeurn Yi, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 2 ) page： 269 - 280   2019.5

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.18999/nagjms.81.2.269

    Web of Science

    PubMed

  41. Consumption of foods containing prohibited artificial colors among middle-school children in Nay Pyi Taw union territory, Myanmar Reviewed International coauthorship

    Oo Nwe, Saw Yu Mon, Aye Hnin Nwe Ni, Aung Zaw Zaw, Kyaw Hnin Nandar, Tun Ae Mon, Kariya Tetsuyoshi, Yamamoto Eiko, Hamajima Nobuyuki

    BMC PUBLIC HEALTH   Vol. 19 ( 1 ) page： 344   2019.3

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s12889-019-6669-5

    Web of Science

    PubMed

  42. Survival rate and mortality risk factors among TB-HIV co-infected patients at an HIV-specialist hospital in Myanmar: A 12-year retrospective follow-up study Reviewed International coauthorship

    Aung Zaw Zaw, Saw Yu Mon, Saw Thu Nandar, Oo Nwe, Aye Hnin Nwe Ni, Aung Sithu, Oo Htun Nyunt, Cho Su Myat, Khaing Moe, Kariya Tetsuyoshi, Yamamoto Eiko, Hamajima Nobuyuki

    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES   Vol. 80   page： 10 - 15   2019.3

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ijid.2018.12.008

    Web of Science

    PubMed

  43. Antibiotic prescription for under-fives with common cold or upper respiratory tract infection in Savannakhet Province, Lao PDR Reviewed International coauthorship

    Keohavong Bounxou, Vonglokham Manithong, Phoummalaysith Bounfeng, Louangpradith Viengsakhone, Inthaphatha Souphalak, Kariya Tetsuyoshi, Saw Yu Mon, Yamamoto Eiko, Hamajima Nobuyuki

    TROPICAL MEDICINE AND HEALTH   Vol. 47   page： 16   2019.2

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s41182-019-0143-z

    Web of Science

    PubMed

  44. Free and universal access to primary healthcare in Mongolia: the service availability and readiness assessment Reviewed International coauthorship

    Jigjidsuren Altantuya, Byambaa Tumurbat, Altangerel Enkhjargal, Batbaatar Suvd, Saw Yu Mon, Kariya Tetsuyoshi, Yamamoto Eiko, Hamajima Nobuyuki

    BMC HEALTH SERVICES RESEARCH   Vol. 19 ( 1 ) page： 129   2019.2

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s12913-019-3932-5

    Web of Science

    PubMed

  45. Epidemiological characteristics and trends of a Nationwide measles outbreak in Mongolia, 2015-2016 Reviewed International coauthorship

    Orsoo Oyunchimeg, Saw Yu Mon, Sereenen Enkhbold, Yadamsuren Buyanjargal, Byambaa Ariunsanaa, Kariya Tetsuyoshi, Yamamoto Eiko, Hamajima Nobuyuki

    BMC PUBLIC HEALTH   Vol. 19 ( 1 ) page： 201   2019.2

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s12889-019-6511-0

    Web of Science

    PubMed

  46. Factors associated with antenatal care visits in Afghanistan: secondary analysis of Afghanistan Demographic and Health Survey 2015 Reviewed International coauthorship

    Azimi Mohammad Walid, Yamamoto Eiko, Saw Yu Mon, Kariya Tetsuyoshi, Arab Ahmad Shekib, Sadaat Said Iftekhar, Farzad Fraidoon, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 1 ) page： 121 - 131   2019.2

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.18999/nagjms.81.1.121

    Web of Science

    PubMed

  47. Patient satisfaction on the utilization of traditional and complementary medicine services at public hospitals in Malaysia Reviewed International coauthorship

    Kaur Jaspal, Hamajima Nobuyuki, Yamamoto Eiko, Saw Yu Mon, Kariya Tetsuyoshi, Soon Goh Cheng, Amin Ariyani, Halim Adilla Nur, Aziz Farhana Abdul, Sharon Suraya Hani

    COMPLEMENTARY THERAPIES IN MEDICINE   Vol. 42   page： 422 - 428   2019.2

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ctim.2018.12.013

    Web of Science

    PubMed

  48. Knowledge, attitude, and usage pattern of tobacco among high school students in Nay Pyi Taw, Myanmar Reviewed International coauthorship

    Myint Myat Noe Htin Aung, Yamamoto Eiko, Ko Min Htet, Khaing Moe, Reyer Joshua A., Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 1 ) page： 65 - 79   2019.2

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.18999/nagjms.81.1.65

    Web of Science

    PubMed

  49. Healthcare waste management at primary health centres in Mon State, Myanmar: the comparisons between hospital and non-hospital type primary health centres Reviewed International coauthorship

    Win Ei Mon, Saw Yu Mon, Oo Kyi Lwin, Than Thet Mon, Cho Su Myat, Kariya Tetsuyoshi, Yamamoto Eiko, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 1 ) page： 81 - 91   2019.2

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.18999/nagjms.81.1.81

    Web of Science

    PubMed

  50. The role of E2F8 in the human placenta Reviewed International coauthorship

    Mizuno Masako, Miki Rika, Moriyama Yoshinori, Ushida Takafumi, Imai Kenji, Niimi Kaoru, Nakano Tomoko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Senga Takeshi, Iwase Akira, Kikkawa Fumitaka, Kotani Tomomi

    MOLECULAR MEDICINE REPORTS   Vol. 19 ( 1 ) page： 293 - 301   2019.1

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.3892/mmr.2018.9617

    Web of Science

    PubMed

  51. Assessing the operational costs of routine immunization activities at the sub-center level in Myanmar: What matters for increasing national immunization coverage ?

    Aye Hnin Nwe Ni, Saw Yu Mon, Thar Aye Mya Chan, Oo Nwe, Aung Zaw Zaw, Tin Htun, Than Thet Mon, Kariya Tetsuyoshi, Yamamoto Eiko, Hamajima Nobuyuki

    VACCINE   Vol. 36 ( 49 ) page： 7542 - 7548   2018.11

    　More details

  52. Myanmar language version of the Revised Hasegawa's Dementia Scale

    Saw Yu Mon, Than Thet Mon, Win Ei Mon, Cho Su Myat, Khaing Moe, Latt Nyi Nyi, Aung Zaw Zaw, Oo Nwe, Aye Hnin Nwe Ni, Kariya Tetsuyoshi, Yamamoto Eiko, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 4 ) page： 435 - 450   2018.11

    　More details

  53. Associations of treatment completion against drug addiction with motivational interviewing and related factors in Afghanistan

    Rasekh Bakhtar, Saw Yu Mon, Azimi Sayed, Kariya Tetsuyoshi, Yamamoto Eiko, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 3 ) page： 329 - 340   2018.8

    　More details

  54. Tobacco Control Law awareness, enforcement, and compliance among high school students in Myanmar

    Latt Nyi Nyi, Saw Yu Mon, Cho Su Myat, Kariya Tetsuyoshi, Yamamoto Eiko, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 3 ) page： 379 - 389   2018.8

    　More details

  55. Factors associated with routine immunization coverage of children under one year old in Lao People's Democratic Republic

    Phoummalaysith Bounfeng, Yamamoto Eiko, Xeuatvongsa Anonh, Louangpradith Viengsakhone, Keohavong Bounxou, Saw Yu Mon, Hamajima Nobuyuki

    VACCINE   Vol. 36 ( 19 ) page： 2666 - 2672   2018.5

    　More details

  56. Waiting time in the outpatient clinic at a national hospital in Vietnam

    Suong Thi Thao Nguyen, Yamamoto Eiko, Mai Thi Ngoc Nguyen, Huy Bao Le, Kariya Tetsuyoshi, Yu Mon Saw, Cong Duc Nguyen, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 2 ) page： 227 - 239   2018.5

    　More details

  57. Dengue fever during pregnancy.

    Tien Dat T, Kotani T, Yamamoto E, Shibata K, Moriyama Y, Tsuda H, Yamashita M, Kajiyama H, Duc Thien Minh D, Quang Thanh L, Kikkawa F

    Nagoya journal of medical science   Vol. 80 ( 2 ) page： 241 - 247   2018.5

    　More details

    Language：English  

    DOI： 10.18999/nagjms.80.2.241

    PubMed

  58. Secondary cytoreductive surgery potentially improves the oncological outcomes of patients with recurrent uterine sarcomas

    Nakamura Kenichi, Kajiyama Hiroaki, Utsumi Fumi, Suzuki Shiro, Niimi Kaoru, Sekiya Ryuichiro, Sakata Jun, Yamamoto Eiko, Shibata Kiyosumi, Kikkawa Fumitaka

    MOLECULAR AND CLINICAL ONCOLOGY   Vol. 8 ( 3 ) page： 499 - 503   2018.3

    　More details

  59. Establishment of an antibody specific for cancer-associated haptoglobin: a possible implication of clinical investigation.

    Nishino K, Koda S, Kataoka N, Takamatsu S, Nakano M, Ikeda S, Kamamatsu Y, Morishita K, Moriwaki K, Eguchi H, Yamamoto E, Kikkawa F, Tomita Y, Kamada Y, Miyoshi E

    Oncotarget   Vol. 9 ( 16 ) page： 12732 - 12744   2018.2

    　More details

    Language：English  

    DOI： 10.18632/oncotarget.24332

    PubMed

  60. Estimated costs for treatment and prophylaxis of newborn vitamin K deficiency bleeding in Tashkent, Uzbekistan

    Tursunov Doniyorjon, Yoshida Yoshitoku, Yrysov Keneshbek, Sabirov Dilmurad, Alimova Khilola, Yamamoto Eiko, Reyer Joshua A., Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 1 ) page： 11 - 20   2018.2

    　More details

  61. The expression of Toll-like receptor 5 in preterm histologic chorioamnionitis

    Moroi Hiroaki, Kotani Tomomi, Miki Rika, Tsuda Hiroyuki, Mizuno Masako, Ito Yumiko, Ushida Takafumi, Mai Kenji, Nakano Tomoko, Li Hua, Sumigama Seiji, Yamamoto Eiko, Was Akira, Kikkawa Fumitaka

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   Vol. 62 ( 1 ) page： 63 - 67   2018.1

    　More details

  62. Inhibition of ZEB1 leads to inversion of metastatic characteristics and restoration of paclitaxel sensitivity of chronic chemoresistant ovarian carcinoma cells

    Sakata Jun, Utsumi Fumi, Suzuki Shiro, Niimi Kaoru, Yamamoto Eiko, Shibata Kiyosumi, Senga Takeshi, Kikkawa Fumitaka, Kajiyama Hiroaki

    ONCOTARGET   Vol. 8 ( 59 ) page： 99482 - 99494   2017.11

    　More details

  63. Medical facility statistics in Japan

    Hamajima Nobuyuki, Sugimoto Takuya, Hasebe Ryo, Cho Su Myat, Khaing Moe, Kariya Tetsuyoshi, Saw Yu Mon, Yamamoto Eiko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 79 ( 4 ) page： 515 - 525   2017.11

    　More details

  64. Unit cost of healthcare services at 200-bed public hospitals in Myanmar: what plays an important role of hospital budgeting?

    Than Thet Mon, Saw Yu Mon, Khaing Moe, Win Ei Mon, Cho Su Myat, Kariya Tetsuyoshi, Yamamoto Eiko, Hamajima Nobuyuki

    BMC HEALTH SERVICES RESEARCH   Vol. 17 ( 1 ) page： 669   2017.9

    　More details

  65. Establishment and characterization of cell lines derived from complete hydatidiform mole

    Yamamoto Eiko, Niimi Kaoru, Kiyono Tohru, Yamamoto Toshimichi, Nishino Kimihiro, Nakamura Kenichi, Kotani Tomomi, Kajiyama Hiroaki, Shibata Kiyosumi, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE   Vol. 40 ( 3 ) page： 614 - 622   2017.9

    　More details

  66. Erratum: High-dose chemotherapy with autologous peripheral blood stem cell transplantation for choriocarcinoma: A case report and literature review.

    Yamamoto E, Niimi K, Fujikake K, Nishida T, Murata M, Mitsuma A, Ando Y, Kikkawa F

    Molecular and clinical oncology   Vol. 7 ( 3 ) page： 510   2017.9

    　More details

    Language：English  

    DOI： 10.3892/mco.2017.1315

    PubMed

  67. Assessment of knowledge about snakebite management amongst healthcare providers in the provincial and two district hospitals in Savannakhet Province, Lao PDR

    Inthanomchanh Vongphoumy, Reyer Joshua A., Blessmen Joerg, Phrasisombath Ketkesone, Yamamoto Eiko, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 79 ( 3 ) page： 299 - 311   2017.8

    　More details

  68. Spontaneous regression of gestational trophoblastic neoplasia.

    Niimi K, Yamamoto E, Nishino K, Fujiwara S, Ino K, Kikkawa F

    Gynecologic oncology reports   Vol. 21   page： 98 - 100   2017.8

    　More details

  69. N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma

    Nishino Kimihiro, Yamamoto Eiko, Niimi Kaoru, Sekiya Yoko, Yamashit Yoriko, Kikkawa Fumitaka

    ONCOLOGY REPORTS   Vol. 38 ( 1 ) page： 440 - 448   2017.7

    　More details

  70. Knowledge of free delivery policy among women who delivered at health facilities in Oudomxay Province, Lao PDR

    Chankham Tengbriacheu, Yamamoto Eiko, Reyer Joshua A., Arafat Rahman, Khonemany Innoukham, Panome Sayamoungkhoun, Hongkham Dalavong, Bounfeng Phommalaysith, Anonh Xeuthvongsa, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 79 ( 2 ) page： 135 - 145   2017.5

    　More details

  71. Lao language version of the Revised Hasegawa's Dementia Scale

    Kounnavong Sengchanh, Soundavong Khouanchay, Xayavong Syda, Vongpraserth Nialoun, Bounsavath Phongsavang, Houatthongkham Souphatsone, Phoummalaysith Bounfeng, Saw Yu Mon, Yamamoto Eiko, Toba Kenji, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 79 ( 2 ) page： 241 - 249   2017.5

    　More details

  72. Socio-economic and demographic determinants of full immunization among children of 12-23 months in Afghanistan

    Farzad Fraidoon, Reyer Joshua A., Yamamoto Eiko, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 79 ( 2 ) page： 179 - 188   2017.5

    　More details

  73. Underlying Cause of Death Recorded during 2013 to 2015 at a Tertiary General Hospital in Vientiane Capital, Lao PDR

    Phoummalaysith Bounfeng, Louangpradith Viengsakhone, Manivon Tavanh, Keohavong Bounxou, Yamamoto Eiko, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 79 ( 2 ) page： 199 - 209   2017.5

    　More details

  74. c-Rel Promotes Invasion of Choriocarcinoma Cells via PI3K/AKT Signaling

    Sekiya Yoko, Yamamoto Eiko, Niimi Kaoru, Nishino Kimihiro, Nakamura Kenichi, Kotani Tomomi, Kajiyama Hiroaki, Shibata Kiyosumi, Kikkawa Fumitaka

    ONCOLOGY   Vol. 92 ( 5 ) page： 299 - 310   2017

    　More details

  75. Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model

    Ushida Takafumi, Kotani Tomomi, Tsuda Hiroyuki, Imai Kenji, Nakano Tomoko, Hirako Shima, Ito Yumiko, Li Hua, Mano Yukio, Wang Jingwen, Miki Rika, Yamamoto Eiko, Iwase Akira, Bando Yasuko K., Hirayama Masaaki, Ohno Kinji, Toyokuni Shinya, Kikkawa Fumitaka

    FREE RADICAL BIOLOGY AND MEDICINE   Vol. 101   page： 524 - 533   2016.12

    　More details

  76. High-dose chemotherapy with autologous peripheral blood stem cell transplantation for choriocarcinoma: A case report and literature review.

    Yamamoto E, Niimi K, Fujikake K, Nishida T, Murata M, Mitsuma A, Ando Y, Kikkawa F

    Molecular and clinical oncology   Vol. 5 ( 5 ) page： 660 - 664   2016.11

    　More details

    Language：English  

    DOI： 10.3892/mco.2016.1011

    PubMed

  77. A PROSPECTIVE STUDY FOR THE EXPECTANT MANAGEMENT OF PLACENTAL POLYP

    Takikawa Sachiko, Iwase Akira, Sato Shizuka, Nakamura Kenichi, Nagai Takashi, Kasahara Yukiyo, Osuka Satoko, Niimi Kaoru, Imai Kenji, Nakano Tomoko, Tsuda Hiroyuki, Yamamoto Eiko, Kotani Tomomi, Goto Maki, Kikkawa Fumitaka

    PLACENTA   Vol. 46   page： 106 - 106   2016.10

    　More details

    Language：Japanese  

    Web of Science

  78. Gestational Trophoblastic Neoplasia and Pregnancy Outcome After Routine Second Curettage for Hydatidiform Mole A Retrospective Observational Study.

    Kan M, Yamamoto E, Niimi K, Tamakoshi K, Sekiya Y, Nishino K, Ino K, Kikkawa F

    The Journal of reproductive medicine   Vol. 61 ( 7-8 ) page： 373 - 379   2016.8

    　More details

    Language：English  

    PubMed

  79. Assessment of hand hygiene compliance after hand hygiene education among health care workers in Cambodia

    Sansam Sim, Yamamoto Eiko, Srun Sok, Sinath Yin, Moniborin Mey, Sim Kheang Bun, Reyer Joshua A., Yoshida Yoshitoku, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 78 ( 2 ) page： 151 - 162   2016.5

    　More details

    Language：Japanese  

    Web of Science

  80. Assessment of hand hygiene compliance after hand hygiene education among health care workers in Cambodia.

    Sansam S, Yamamoto E, Srun S, Sinath Y, Moniborin M, Bun Sim K, Reyer JA, Yoshida Y, Hamajima N

    Nagoya journal of medical science   Vol. 78 ( 2 ) page： 151 - 62   2016.5

    　More details

    Language：English  

    PubMed

  81. Healthcare in Myanmar

    Latt Nyi Nyi, Cho Su Myat, Htun Nang Mie Mie, Saw Yu Mon, Myint Myat Noe Htin Aung, Aoki Fumiko, Reyer Joshua A., Yamamoto Eiko, Yoshida Yoshitoku, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 78 ( 2 ) page： 123 - 134   2016.5

    　More details

    Language：Japanese  

    Web of Science

  82. Healthcare in Myanmar.

    Latt NN, Myat Cho S, Htun NM, Yu Mon Saw, Myint MN, Aoki F, Reyer JA, Yamamoto E, Yoshida Y, Hamajima N

    Nagoya journal of medical science   Vol. 78 ( 2 ) page： 123 - 34   2016.5

    　More details

    Language：English  

    PubMed

  83. Acute malnutrition among under-five children in Faryab, Afghanistan: prevalence and causes

    Frozanfar Muhammad Kamel, Yoshida Yoshitoku, Yamamoto Eiko, Reyer Joshua A., Dalil Suraya, Rahimzad Abdullah Darman, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 78 ( 1 ) page： 41 - 53   2016.2

    　More details

    Language：Japanese  

    Web of Science

  84. Acute malnutrition among under-five children in Faryab, Afghanistan: prevalence and causes.

    Frozanfar MK, Yoshida Y, Yamamoto E, Reyer JA, Dalil S, Rahimzad AD, Hamajima N

    Nagoya journal of medical science   Vol. 78 ( 1 ) page： 41 - 53   2016.2

    　More details

    Language：English  

    PubMed

  85. Pediatric cardiothoracic program in Malaysia: a study based on the outcome of the program.

    Piros Kulandasamy Pillai C, Yoshida Y, Justin Lawrence P, Yamamoto E, Reyer JA, Hamajima1 N

    Nagoya journal of medical science   Vol. 78 ( 1 ) page： 9 - 17   2016.2

    　More details

    Language：English  

    PubMed

  86. Trends in attrition among medical teaching staff at universities in Myanmar 2009-2013.

    Nang Mie Mie Htun, Reyer JA, Yamamoto E, Yoshida Y, Hamajima N

    Nagoya journal of medical science   Vol. 78 ( 1 ) page： 27 - 40   2016.2

    　More details

    Language：English  

    PubMed

  87. Trends in amenable mortality rate in the Mongolian population, 2007-2014.

    Surenjav E, Sovd T, Yoshida Y, Yamamoto E, Reyer JA, Hamajima N

    Nagoya journal of medical science   Vol. 78 ( 1 ) page： 55 - 68   2016.2

    　More details

    Language：English  

    PubMed

  88. Pediatric cardiothoracic program in Malaysia: a study based on the outcome of the program

    Pillai Cornelius Piros Kulandasamy, Yoshida Yoshitoku, Lawrence Patrick Justin, Yamamoto Eiko, Reyer Joshua A., Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 78 ( 1 ) page： 9 - 17   2016.2

    　More details

    Language：Japanese  

    Web of Science

  89. Trends in amenable mortality rate in the Mongolian population, 2007-2014

    Surenjav Enkhjin, Sovd Tugsdelger, Yoshida Yoshitoku, Yamamoto Eiko, Reyer Joshua A., Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 78 ( 1 ) page： 55 - 68   2016.2

    　More details

    Language：Japanese  

    Web of Science

  90. Trends in attrition among medical teaching staff at universities in Myanmar 2009-2013

    Htun Nang Mie Mie, Reyer Joshua A., Yamamoto Eiko, Yoshida Yoshitoku, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 78 ( 1 ) page： 27 - 40   2016.2

    　More details

    Language：Japanese  

    Web of Science

  91. Gestational Trophoblastic Neoplasia and Pregnancy Outcome After Routine Second Curettage for Hydatidiform Mole: A Retrospective Observational Study

    Kan Momo, Yamamoto Eiko, Niimi Kaoru, Tamakoshi Koji, Sekiya Yoko, Nishino Kimihiro, Ino Kazuhiko, Kikkawa Fumitaka

    JOURNAL OF REPRODUCTIVE MEDICINE   Vol. 61 ( 7-8 ) page： 373 - 379   2016

    　More details

    Language：Japanese  

    Web of Science

  92. THE MANAGEMENT OF PLACENTAL ABRUPTION

    Kotani Tomomi, Moroi Hiroaki, Nakano Tomoko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Kikkawa Fumitaka

    PLACENTA   Vol. 36 ( 9 ) page： A49 - A49   2015.9

    　More details

    Language：Japanese  

    Web of Science

  93. Opioid needs of terminally ill patients with gynecologic malignancies

    Utsumi Fumi, Kajiyama Hiroaki, Sakata Jun, Higashi Makiko, Niimi Kaoru, Sekiya Ryuichiro, Mitsui Hiroko, Suzuki Shiro, Umezu Tomokazu, Mizuno Mika, Yamamoto Eiko, Shibata Kiyosumi, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 20 ( 2 ) page： 405 - 410   2015.4

    　More details

  94. A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age. Reviewed

    Kajiyama H, Mizuno M, Shibata K, Umezu T, Suzuki S, Yamamoto E, Mitsui H, Sekiya R, Niimi K, Kawai M, Nagasaka T, Kikkawa F.

    Int J Clin Oncol.   Vol. 19 ( 5 ) page： 921 - 927   2014.10

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10147-013-0645-3

    Web of Science

    PubMed

  95. Oncologic outcome after recurrence in patients with stage I epithelial ovarian cancer: are clear-cell and mucinous histological types a different entities?

    Kajiyama Hiroaki, Mizuno Mika, Shibata Kiyosumi, Umezu Tomokazu, Suzuki Shiro, Yamamoto Eiko, Mitsui Hiroko, Sekiya Ryuichiro, Niimi Kaoru, Kawai Michiyasu, Nagasaka Tetsuro, Kikkawa Fumitaka

    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY   Vol. 181   page： 305 - 310   2014.10

    　More details

  96. WHAT A ROLE ATYPICAL E2F PLAYS IN HUMAN PLACENTAL DEVELOPMENT?

    Sawada Masako, Kotani Tomomi, Miki Rika, Li Hua, Moroi Hiroaki, Imai Kenji, Nakano Tomoko, Niimi Kaoru, Yamamoto Eiko, Mano Yukio, Tsuda Hiroyuki, Sumigama Seiji, Kikkawa Fumitaka

    PLACENTA   Vol. 35 ( 10 ) page： A12 - A12   2014.10

    　More details

    Language：Japanese  

    Web of Science

  97. CORE 2 beta 1, 6-N ACETYLGLCOSAMINYL TRANSFERASE MAY REGULATE CELL INVASION IN CHORIOCARCINOMA

    Niimi Kaoru, Yamamoto Eiko, Miwa Yoko, Nishino Kimihiro, Mano Yukio, Sumigama Seiji, Kotani Tomomi, Kikkawa Fumitaka

    PLACENTA   Vol. 35 ( 9 ) page： A49 - A50   2014.9

    　More details

    Language：Japanese  

    Web of Science

  98. TRANSCRIPTIONAL REGULATION OF HUMAN N-ACETYLGLUCOSAMINYLTRANSFERASE IVA GENE IN TROPHOBLASIS

    Miwa Yoko, Yamamoto Eiko, Shinjo Kanako, Niimi Kaoru, Nishino Kimihiro, Mano Yukio, Sumigama Seiji, Kotani Tomomi, Kikkawa Fumitaka

    PLACENTA   Vol. 35 ( 9 ) page： A50 - A50   2014.9

    　More details

    Language：Japanese  

    Web of Science

  99. POSSIBLE INVOLVEMENT OF ENDOGLIN IN THE PATHOGENESIS OF PREECLAMPSIA

    Mano Yukio, Ushida Takafumi, Nakano Tomoko, Niimi Kaoru, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Kotani Tomomi, Kikkawa Fumitaka

    PLACENTA   Vol. 35 ( 9 ) page： A82 - A83   2014.9

    　More details

    Language：Japanese  

    Web of Science

  100. Identification of causative pregnancy of gestational trophoblastic neoplasia diagnosed during pregnancy by short tandem repeat analysis. Reviewed

    Yamamoto E, Niimi K, Shinjo K, Yamamoto T, Fukunaga M, Kikkawa F

    Gynecologic oncology case reports   Vol. 9 ( 18 ) page： 3 - 6   2014.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.gynor.2014.04.001

    PubMed

  101. Expression of chromobox homolog 7 ( CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation

    Shinjo Kanako, Yamashita Yoriko, Yamamoto Eiko, Akatsuka Shinya, Uno Nozomi, Kamiya Akihiro, Niimi Kaoru, Sakaguchi Yuka, Nagasaka Tetsuro, Takahashi Takashi, Shibata Kiyosumi, Kajiyama Hiroaki, Kikkawa Fumitaka, Toyokuni Shinya

    INTERNATIONAL JOURNAL OF CANCER   Vol. 135 ( 2 ) page： 308 - 318   2014.7

    　More details

  102. Possible association between stem-like hallmark and radioresistance in human cervical carcinoma cells

    Kumazawa Shoko, Kajiyama Hiroaki, Umezu Tomokazu, Mizuno Mika, Suzuki Shiro, Yamamoto Eiko, Mitsui Hiroko, Sekiya Ryuichiro, Shibata Kiyosumi, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 40 ( 5 ) page： 1389 - 1398   2014.5

    　More details

  103. Suppression of REV7 enhances cisplatin sensitivity in ovarian clear cell carcinoma cells

    Niimi Kaoru, Murakumo Yoshiki, Watanabe Naoki, Kato Takuya, Mii Shinji, Enomoto Atsushi, Asai Masato, Asai Naoya, Yamamoto Eiko, Kajiyama Hiroaki, Shibata Kiyosumi, Kikkawa Fumitaka, Takahashi Masahide

    CANCER SCIENCE   Vol. 105 ( 5 ) page： 545 - 552   2014.5

    　More details

  104. Recurrence-predicting prognostic factors for patients with early-stage epithelial ovarian cancer undergoing fertility-sparing surgery: a multi-institutional study

    Kajiyama Hiroaki, Mizuno Mika, Shibata Kiyosumi, Yamamoto Eiko, Kawai Michiyasu, Nagasaka Tetsuro, Kikkawa Fumitaka

    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY   Vol. 175   page： 97 - 102   2014.4

    　More details

  105. Is There Any Association between Where Patients Spend the End of Life and Survival after Anticancer Treatment for Gynecologic Malignancy?

    Kajiyama Hiroaki, Utsumi Fumi, Higashi Makiko, Sakata Jun, Sekiya Ryuichiro, Mizuno Mika, Umezu Tomokazu, Suzuki Shiro, Yamamoto Eiko, Mitsui Hiroko, Niimi Kaoru, Shibata Kiyosumi, Kikkawa Fumitaka

    JOURNAL OF PALLIATIVE MEDICINE   Vol. 17 ( 3 ) page： 325 - 330   2014.3

    　More details

  106. Survival benefit of taxane plus platinum in recurrent ovarian cancer with non-clear cell, non-mucinous histology

    Kajiyama Hiroaki, Shibata Kiyosumi, Mizuno Mika, Umezu Tomokazu, Suzuki Shiro, Sekiya Ryuichiro, Niimi Kaoru, Mitsui Hiroko, Yamamoto Eiko, Kawai Michiyasu, Nagasaka Tetsuro, Kikkawa Fumitaka

    JOURNAL OF GYNECOLOGIC ONCOLOGY   Vol. 25 ( 1 ) page： 43 - 50   2014.1

    　More details

  107. POSSIBLE INVOLVEMENT OF ENDOGLIN IN THE PATHOGENESIS OF PREGNANCY INDUCED HYPERTENSION

    Mano Yukio, Ushida Takafumi, Hirako Shima, Moroi Hiroaki, Imai Kenji, Sawada Masako, Nakano Tomoko, Hattori Yuka, Watanabe Yuriko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Kotani Tomomi, Kikkawa Fumitaka

    PLACENTA   Vol. 34 ( 10 ) page： A14 - A14   2013.10

    　More details

  108. Altered Expression of Enzymes Regulating the Activity of Endothelin-1 in the Lower Segment of the Human Amnion During Labor

    Kotani Tomomi, Iwase Akira, Tsuda Hiroyuki, Mano Yukio, Yamamoto Eiko, Nakano Tomoko, Hasegawa Yumi, Li Hua, Sumigama Seiji, Itakura Atsuo, Kikkawa Fumitaka

    BIOLOGY OF REPRODUCTION   Vol. 89 ( 3 ) page： 52   2013.9

    　More details

  109. An HLA-modified ovarian cancer cell line induced CTL responses specific to an epitope derived from claudin-1 presented by HLA-A*24:02 molecules

    Kondo Shinji, Demachi-Okamura Ayako, Hirosawa Tomoya, Maki Hiroyuki, Fujita Mitsugu, Uemura Yasushi, Akatsuka Yoshiki, Yamamoto Eiko, Shibata Kiyosumi, Ino Kazuhiko, Kikkawa Fumitaka, Kuzushima Kiyotaka

    HUMAN IMMUNOLOGY   Vol. 74 ( 9 ) page： 1103 - 1110   2013.9

    　More details

  110. THE EXPRESSIONS OF ECE-1 AND NEP ARE REGULATED BY TLR-4 SIGNALLING IN GESTATIONAL TISSUES

    Kotani Tomomi, Mano Yukio, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Li Hua, Watanabe Yuriko, Nakano Tomoko, Kikkawa Fumitaka

    PLACENTA   Vol. 34 ( 9 ) page： A43 - A43   2013.9

    　More details

  111. The expression and characterization of endoglin in uterine leiomyosarcoma

    Mitsui Hiroko, Shibata Kiyosumi, Mano Yukio, Suzuki Shiro, Umezu Tomokazu, Mizuno Mika, Yamamoto Eiko, Kajiyama Hiroaki, Kotani Tomomi, Senga Takeshi, Kikkawa Fumitaka

    CLINICAL & EXPERIMENTAL METASTASIS   Vol. 30 ( 6 ) page： 731 - 740   2013.8

    　More details

  112. Anti-Mullerian hormone as a marker of ovarian reserve following chemotherapy in patients with gestational trophoblastic neoplasia

    Iwase Akira, Sugita Atsuko, Hirokawa Wakana, Goto Maki, Yamamoto Eiko, Takikawa Sachiko, Nakahara Tatsuo, Nakamura Tomoko, Kondo Mika, Kikkawa Fumitaka

    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY   Vol. 167 ( 2 ) page： 194 - 198   2013.4

    　More details

  113. Expression of Twist enhances risk of poor oncologic outcome in patients with stage Ib to II cervical carcinoma with lymphovascular space involvement

    Kajiyama Hiroaki, Shibata Kiyosumi, Umezu Tomokazu, Mizuno Mika, Suzuki Shiro, Yamamoto Eiko, Fujiwara Sawako, Kikkawa Fumitaka

    HUMAN PATHOLOGY   Vol. 44 ( 2 ) page： 181 - 188   2013.2

    　More details

  114. High expression of N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma

    Niimi K., Yamamoto E., Fujiwara S., Shinjo K., Kotani T., Umezu T., Kajiyama H., Shibata K., Ino K., Kikkawa F.

    BRITISH JOURNAL OF CANCER   Vol. 107 ( 12 ) page： 1969 - 1977   2012.12

    　More details

  115. A case report of placental mesenchymal dysplasia with an increased VEGF-D expression

    Kotani T., Sumigama S., Tsuda H., Mano Y., Yamamoto E., Iwase A., Shimoyama Y., Nagasaka T., Hayakawa H., Yamamoto T., Ino K., Kikkawa F.

    PLACENTA   Vol. 33 ( 10 ) page： 888 - 891   2012.10

    　More details

  116. MOLECULAR GENETIC DIAGNOSIS OF TWO RARE CASES OF GESTATIONAL TROPHOBLASTIC NEOPLASIA

    Fujiwara Sawako, Yamamoto Eiko, Kan Momo, Niimi Kaoru, Shinjyo Kanako, Mano Yukio, Tsuda Hiroyuki, Sumigama Seiji, Kotani Tomomi, Kikkawa Fumitaka

    PLACENTA   Vol. 33 ( 9 ) page： A107 - A107   2012.9

    　More details

    Language：Japanese  

    Web of Science

  117. ROLE OF N-ACETYLGLUCOSAMINYLTRANSFERASE IVA IN CHORIOCARCINOMA

    Niimi Kaoru, Yamamoto Eiko, Mano Yukio, Tsuda Hiroyuki, Sumigama Seiji, Shinjo Kanako, Fujiwara Sawako, Kotani Tomomi, Kikkawa Fumitaka

    PLACENTA   Vol. 33 ( 9 ) page： A50 - A50   2012.9

    　More details

    Language：Japanese  

    Web of Science

  118. [The diagnosis and treatment for choriocarcinoma].

    Yamamoto E, Fujiwara S, Kikkawa F

    Nihon rinsho. Japanese journal of clinical medicine   Vol. 70 Suppl 4   page： 727 - 32   2012.6

    　More details

    Language：Japanese  

    PubMed

  119. Expression of CXCR4 indicates poor prognosis in patients with clear cell carcinoma of the ovary

    Sekiya Ryuichiro, Kajiyama Hiroaki, Sakai Kotaro, Umezu Tomokazu, Mizuno Mika, Shibata Kiyosumi, Yamamoto Eiko, Fujiwara Sawako, Nagasaka Tetsuro, Kikkawa Fumitaka

    HUMAN PATHOLOGY   Vol. 43 ( 6 ) page： 904 - 910   2012.6

    　More details

  120. Postrecurrent Oncologic Outcome of Patients With Ovarian Clear Cell Carcinoma

    Kajiyama Hiroaki, Shibata Kiyosumi, Mizuno Mika, Yamamoto Eiko, Fujiwara Sawako, Umezu Tomokazu, Suzuki Shiro, Nakanishi Toru, Nagasaka Tetsuro, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 22 ( 5 ) page： 801 - 806   2012.6

    　More details

  121. Normal human chorionic gonadotropin regression curves in uneventful postmolar patients.

    Kizaki S, Matsui H, Usui H, Shozu M, Hanawa S, Yamamoto E, Kikkawa F

    The Journal of reproductive medicine   Vol. 57 ( 5-6 ) page： 243 - 8   2012.5

    　More details

    Language：English  

    PubMed

  122. Long-Term Clinical Outcome of Patients With Recurrent Epithelial Ovarian Carcinoma Is it the Same for Each Histological Type?

    Kajiyama Hiroaki, Shibata Kiyosumi, Mizuno Mika, Umezu Tomokazu, Suzuki Shiro, Yamamoto Eiko, Fujiwara Sawako, Kawai Michiyasu, Nagasaka Tetsuro, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 22 ( 3 ) page： 394 - 399   2012.3

    　More details

  123. Prognostic factors in stage IA-IIA cervical cancer patients treated surgically: does the waiting time to the operation affect survival?

    Umezu Tomokazu, Shibata Kiyosumi, Kajiyama Hiroaki, Yamamoto Eiko, Mizuno Mika, Kikkawa Fumitaka

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS   Vol. 285 ( 2 ) page： 493 - 497   2012.2

    　More details

  124. Normal Human Chorionic Gonadotropin Regression Curves in Uneventful Postmolar Patients

    Kizaki Shoko, Matsui Hideo, Usui Hirokazu, Shozu Makio, Hanawa Shinsuke, Yamamoto Eiko, Kikkawa Fumitaka

    JOURNAL OF REPRODUCTIVE MEDICINE   Vol. 57 ( 5-6 ) page： 243 - 248   2012

    　More details

    Language：Japanese  

    Web of Science

  125. The Loss of Endoglin Promotes the Invasion of Extravillous Trophoblasts

    Mano Yukio, Kotani Tomomi, Shibata Kiyozumi, Matsumura Hiroko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Iwase Akira, Senga Takeshi, Kikkawa Fumitaka

    ENDOCRINOLOGY   Vol. 152 ( 11 ) page： 4386 - 4394   2011.11

    　More details

  126. ENDOGLIN KNOCKDOWN ATTENUATED THE SUPPRESSIVE ROLE OF ANGIOTENSIN LL ON EXTAVILLOUS TROPHOBRAST INVASION

    Hattori Yuka, Kotani Tomomi, Sumigama Seigi, Mano Yukio, Yamamoto Eiko, Fujiwara Sawako, Niimi Kaoru, Kikkawa Fumitaka

    PLACENTA   Vol. 32 ( 9 ) page： A63 - A63   2011.9

    　More details

    Language：Japanese  

    Web of Science

  127. THE LOSS OF ENDOGLIN PROMOTES THE INVASION OF EXTRAVILLOUS TROPHOBLASTS BY THE INDUCTION OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR

    Mano Yukio, Kotani Tomomi, Shibata Kiyosumi, Matsumura Hiroko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Iwase Akira, Senga Takeshi, Kikkawa Fumitaka

    PLACENTA   Vol. 32 ( 9 ) page： A57 - A57   2011.9

    　More details

    Language：Japanese  

    Web of Science

  128. PLACENTA ACCRETA MIMICKING PLACENTAL SITE TROPHOBLASTIC TUMOR: A CASE REPORT

    Fujiwara Sawako, Niimi Kaoru, Shinjyo Kanako, Yamamoto Eiko, Mano Yukio, Sumigama Seiji, Kotani Tomomi, Kikkawa Fumitaka

    PLACENTA   Vol. 32 ( 9 ) page： A15 - A15   2011.9

    　More details

    Language：Japanese  

    Web of Science

  129. N-ACETYLGLUCOSAMINYLTRANSFERASE IVA MAY REGULATE CELL INVASION IN CHORIOCARCINOMA

    Niimi Kaoru, Yamamoto Eiko, Shinjo Kanako, Fujiwara Sawako, Mano Yukio, Sumigama Seiji, Kotani Tomomi, Kikkawa Fumitaka

    PLACENTA   Vol. 32 ( 9 ) page： A57 - A57   2011.9

    　More details

    Language：Japanese  

    Web of Science

  130. ESTABLISHMENT OF IMMORTALIZED HUMAN COMPLETE HYDATIDIFORM MOLE CELL LINES

    Yamamoto Eiko, Niimi Kaoru, Shinjo Kanako, Fujiwara Sawako, Mano Yukio, Sumigama Seiji, Kotani Tomomi, Kikkawa Fumitaka

    PLACENTA   Vol. 32 ( 9 ) page： A25 - A25   2011.9

    　More details

    Language：Japanese  

    Web of Science

  131. PATHOLOGICAL INVESTIGATION OF PLACENTA PREVIA ACCRETA: THE SITE OF UTERINE WALL AND THE WIDTH/DEPTH OF VILLOUS INVASION

    Sumigama Seiji, Kotani Tomomi, Mano Yukio, Hattori Yuka, Fujiwara Sawako, Yamamoto Eiko, Nagasaka Tetsurou, Kikkawa Fumitaka

    PLACENTA   Vol. 32 ( 9 ) page： A60 - A60   2011.9

    　More details

  132. The invasiveness of extravillous trophoblasts controlled by two bioactive lysophospholipids, S1P and LPA

    Kotani Tomomi, Sumigama Seiji, Tsuda Hiroyuki, Mano Yukio, Sugiyama Chisato, Hironaka Masae, Kawachi Fumitaka, Watanabe Yuriko, Hattori Yuka, Yamamoto Eiko, Kikkawa Fumitaka

    PLACENTA   Vol. 32 ( 9 ) page： A166 - A166   2011.9

    　More details

  133. Role of the Renin-Angiotensin System in Gynecologic Cancers

    Ino K., Shibata K., Yamamoto E., Kajiyama H., Nawa A., Mabuchi Y., Yagi S., Minami S., Tanizaki Y., Kobayashi A., Kikkawa F.

    CURRENT CANCER DRUG TARGETS   Vol. 11 ( 4 ) page： 405 - 411   2011.5

    　More details

    Language：Japanese  

    Web of Science

  134. Role of the renin-angiotensin system in gynecologic cancers.

    Ino K, Shibata K, Yamamoto E, Kajiyama H, Nawa A, Mabuchi Y, Yagi S, Minami S, Tanizaki Y, Kobayashi A, Kikkawa F

    Current cancer drug targets   Vol. 11 ( 4 ) page： 405 - 11   2011.5

    　More details

    Language：English  

    DOI： 10.2174/156800911795538057

    PubMed

  135. Establishment of Cisplatin-Resistant Ovarian Yolk Sac Tumor Cells and Investigation of the Mechanism of Cisplatin Resistance Using This Cell Line

    Shibata Kiyosumi, Umezu Tomokazu, Sakurai Maiko, Kajiyama Hiroaki, Yamamoto Eiko, Ino Kazuhiko, Nawa Akihiro, Kikkawa Fumitaka

    GYNECOLOGIC AND OBSTETRIC INVESTIGATION   Vol. 71 ( 2 ) page： 104 - 111   2011

    　More details

  136. Glypican-3 expression predicts poor clinical outcome of patients with early-stage clear cell carcinoma of the ovary

    Umezu Tomokazu, Shibata Kiyosumi, Kajiyama Hiroaki, Yamamoto Eiko, Nawa Akihiro, Kikkawa Fumitaka

    JOURNAL OF CLINICAL PATHOLOGY   Vol. 63 ( 11 ) page： 962 - 966   2010.11

    　More details

  137. Growth-suppressing function of glypican-3 (GPC3) via insulin like growth factor II (IGF-II) signaling pathway in ovarian clear cell carcinoma cells

    Sakurai Maiko, Shibata Kiyosumi, Umezu Tomokazu, Kajiyama Hiroaki, Yamamoto Eiko, Ino Kazuhiko, Nawa Akihiro, Kikkawa Fumitaka

    GYNECOLOGIC ONCOLOGY   Vol. 119 ( 2 ) page： 332 - 336   2010.11

    　More details

  138. ESTABLISHMENT OF AN IMMORTALIZED HUMAN COMPLETE HYDATIDIFORM MOLE CELL LINE BY RETROVIRAL INFECTION OF HTERT

    Yamamoto Eiko, Hayashi Kanako, Niimi Kaoru, Sumigama Seiji, Kotani Tomomi, Kikkawa Fumitaka

    PLACENTA   Vol. 31 ( 9 ) page： A154 - A154   2010.9

    　More details

    Language：Japanese  

    Web of Science

  139. N-ACETYLGLUCOSAMINYLTRANSFERASE V REGULATES EXTRAVILLOUS TROPHOBLAST INVASION THROUGH GLYCOSYLATION OF alpha 5 beta 1 INTEGRIN

    Yamamoto Eiko, Ino Kazuhiko, Inaba Tomoko, Sumigama Seiji, Kikkawa Tomomi Kotani Furnitaka

    PLACENTA   Vol. 31 ( 9 ) page： A154 - A154   2010.9

    　More details

    Language：Japanese  

    Web of Science

  140. N-ACETYLGLUCOSAMINYLTRANSFERASE IVA REGULATES INVASIVENESS OF CHORIOCARCINOMA CELLS

    Niimi K., Yamamoto E., Hayashi K., Sumigama S., Kotani T., Kikkawa F.

    PLACENTA   Vol. 31 ( 9 ) page： A153 - A153   2010.9

    　More details

    Language：Japanese  

    Web of Science

  141. Fertility-sparing operation for recurrence of uterine cervical perivascular epithelioid cell tumor.

    Yamamoto E, Ino K, Sakurai M, Takigawa S, Iwase A, Kikkawa F

    Rare tumors   Vol. 2 ( 2 ) page： e26   2010.6

    　More details

    Language：English  

    DOI： 10.4081/rt.2010.e26

    PubMed

  142. Indoleamine 2,3-dioxygenase expression predicts impaired survival of invasive cervical cancer patients treated with radical hysterectomy

    Inaba Tomoko, Ino Kazuhiko, Kajiyamaa Hiroaki, Shibata Kiyosumi, Yamamoto Eiko, Kondo Shinji, Umezu Tomokazu, Nawa Akihiro, Takikawa Osamu, Kikkawa Fumitaka

    GYNECOLOGIC ONCOLOGY   Vol. 117 ( 3 ) page： 423 - 428   2010.6

    　More details

  143. Enhanced cytotoxicity with a novel system combining the paclitaxel-2 '-ethylcarbonate prodrug and an HSV amplicon with an attenuated replication-competent virus, HF10 as a helper virus

    Ishida Daisuke, Nawa Akihiro, Tanino Tadatoshi, Goshima Fumi, Luo Chen Hong, Iwaki Masahiro, Kajiyama Hiroaki, Shibata Kiyosumi, Yamamoto Eiko, Ino Kazuhiko, Tsurumi Tatsuya, Nishiyama Yukihiro, Kikkawa Fumitaka

    CANCER LETTERS   Vol. 288 ( 1 ) page： 17 - 27   2010.2

    　More details

  144. Gene silencing of glypican-3 in clear cell carcinoma of the ovary renders it more sensitive to the apoptotic agent paclitaxel in vitro and in vivo

    Umezu Tomokazu, Shibata Kiyosumi, Shimaoka Maiko, Kajiyama Hiroaki, Yamamoto Eiko, Ino Kazuhiko, Nawa Akihiro, Senga Takeshi, Kikkawa Fumitaka

    CANCER SCIENCE   Vol. 101 ( 1 ) page： 143 - 148   2010.1

    　More details

  145. Endometrial Cancer: Indoleamine 2,3-Dioxygenase as a Prognostic Indicator

    Ino Kazuhiko, Yamamoto Eiko, Shibata Kiyosumi, Kajiyama Hiroaki, Nawa Akihiro, Kikwa Fumitaka

    METHODS OF CANCER DIAGNOSIS, THERAPY, AND PROGNOSIS, VOL 6   Vol. 6   page： 285 - 295   2010

    　More details

    Language：Japanese  

    Web of Science

  146. Histamine Stimulates Interleukin-6 Production through Histamine H1 Receptors in Human Amnion Cells

    Morimitsu Akiko, Sumigama Seiji, Kotani Tomomi, Mano Yukio, Suzuki Kanako, Araki-Taguchi Masako, Yamamoto Eiko, Hayakawa Hiromi, Okada Mayumi, Itakura Atsuo, Kikkawa Fumitaka

    GYNECOLOGIC AND OBSTETRIC INVESTIGATION   Vol. 69 ( 1 ) page： 67 - 72   2010

    　More details

  147. High expression of N-acetylglucosaminyltransferase V in mucinous tumors of the ovary

    Takahashi Noriko, Yamamoto Eiko, Ino Kazuhiko, Miyoshi Eiji, Nagasaka Tetsuro, Kajiyama Hiroaki, Shibata Kiyosumi, Nawa Akihiro, Kikkawa Fumitaka

    ONCOLOGY REPORTS   Vol. 22 ( 5 ) page： 1027 - 1032   2009.11

    　More details

  148. Role of the immunosuppressive enzyme indoleamine 2,3-dioxygenase in the progression of ovarian carcinoma

    Inaba Tomoko, Ino Kazuhiko, Kajiyama Hiroaki, Yamamoto Eiko, Shibata Kiyosumi, Nawa Akihiro, Nagasaka Tetsuro, Akimoto Hidetoshi, Takikawa Osamu, Kikkawa Fumitaka

    GYNECOLOGIC ONCOLOGY   Vol. 115 ( 2 ) page： 185 - 192   2009.11

    　More details

  149. Activator Protein-2 Impairs the Invasion of a Human Extravillous Trophoblast Cell Line

    Kotani Tomomi, Iwase Akira, Ino Kazuhiko, Sumigama Seiji, Yamamoto Eiko, Hayakawa Hiromi, Nagasaka Tetsuo, Itakura Atsuo, Nomura Seiji, Kikkawa Fumitaka

    ENDOCRINOLOGY   Vol. 150 ( 9 ) page： 4376 - 4385   2009.9

    　More details

  150. Effectiveness of preoperative concurrent chemoradiation therapy (CCRT) for locally advanced adenocarcinoma of cervix

    Shibata K., Kajiyama H., Yamamoto E., Terauchi M., Ino K., Nomura S., Nawa A., Kawai M., Kikkawa F.

    EJSO   Vol. 35 ( 7 ) page： 768 - 772   2009.7

    　More details

  151. N-Acetylglucosaminyltransferase V Regulates Extravillous Trophoblast Invasion through Glycosylation of alpha 5 beta 1 Integrin

    Yamamoto Eiko, Ino Kazuhiko, Miyoshi Eiji, Inamori Kei-ichiro, Abe Akihiro, Sumigama Seiji, Iwase Akira, Kajiyama Hiroaki, Shibata Kiyosumi, Nawa Akihiro, Kikkawa Fumitaka

    ENDOCRINOLOGY   Vol. 150 ( 2 ) page： 990 - 999   2009.2

    　More details

  152. Tocilizumab Inhibits Interleukin-6-Mediated Matrix Metalloproteinase-2 and-9 Secretions from Human Amnion Cells in Preterm Premature Rupture of Membranes

    Mano Yukio, Shibata Kiyosumi, Sumigama Seiji, Hayakawa Hiromi, Ino Kazuhiko, Yamamoto Eiko, Kajiyama Hiroaki, Nawa Akihiro, Kikkawa Fumitaka

    GYNECOLOGIC AND OBSTETRIC INVESTIGATION   Vol. 68 ( 3 ) page： 145 - 153   2009

    　More details

  153. Is there any possibility of fertility-sparing surgery in patients with clear-cell carcinoma of the ovary?

    Kajiyama Hiroaki, Shibata Kiyosumi, Suzuki Shiro, Ino Kazuhiko, Yamamoto Eiko, Mizuno Kimio, Sakakibara Katsumi, Matsuzawa Katsuji, Takeda Akihiro, Kinoshita Yoshito, Kawai Michiyasu, Nagasaka Tetsuro, Nawa Akihiro, Kikkawa Fumitaka

    GYNECOLOGIC ONCOLOGY   Vol. 111 ( 3 ) page： 523 - 526   2008.12

    　More details

  154. Overexpression of Indoleamine 2,3-Dioxygenase in Human Endometrial Carcinoma Cells Induces Rapid Tumor Growth in a Mouse Xenograft Model

    Yoshida Norio, Ino Kazuhiko, Ishida Yoshiyuki, Kajiyama Hiroaki, Yamamoto Eiko, Shibata Kiyosumi, Terauchi Mikio, Nawa Akihiro, Akimoto Hidetoshi, Takikawa Osamu, Isobe Ken-ichi, Kikkawa Fumitaka

    CLINICAL CANCER RESEARCH   Vol. 14 ( 22 ) page： 7251 - 7259   2008.11

    　More details

  155. N-ACETYLGLUCOSAMINVLTRANSFERASE V REGULATES EXTRAVILLOUS TROPHOBLAST INVASION THROUGH GLUCOSYLATION OF alpha 5 beta 1 INTEGTIN

    Yamamoto Eiko, Ino Kazuhiko, Inaba Tomoko, Sumigama Seiji, Kotani Tomomi, Kikkawa Fumitaka

    PLACENTA   Vol. 29 ( 10 ) page： 916 - 916   2008.10

    　More details

    Language：Japanese  

    Web of Science

  156. Expression of the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) in human normal and malignant invasive trophoblastic cells

    Ino K., Yamamoto E., Kidokoro K., Kikkiawa F.

    PLACENTA   Vol. 29 ( 8 ) page： A94 - A94   2008.8

    　More details

    Language：Japanese  

    Web of Science

  157. N-acetylglucosminyltransferase V regulates extravillous trophoblast invasion through glycosylation of alfa5-beta1 integrin

    Yamamoto Eiko, Ino Kazuhiko, Kidokoro Kumiko, Takahashi Noriko, Inaba Tomoko, Kikkawa Fumitaka

    PLACENTA   Vol. 29 ( 8 ) page： A85 - A85   2008.8

    　More details

    Language：Japanese  

    Web of Science

  158. Feasibility and effectiveness of postoperative adjuvant concurrent chemoradiation therapy in Japanese patients with high-risk early-stage cancer of the uterine cervix

    Shibata Kiyosumi, Kajiyama Hiroaki, Terauchi Mikio, Yamamoto Eiko, Ino Kazuhiko, Nawa Akihiro, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 13 ( 3 ) page： 233 - 238   2008.6

    　More details

  159. Inverse correlation between tumoral indoleamine 2,3-dioxygenase expression and tumor-infiltrating lymphocytes in endometrial cancer: Its association with disease progression and survival

    Ino Kazuhiko, Yamamoto Eiko, Shibata Kiyosumi, Kajiyama Hiroaki, Yoshida Norio, Terauchi Mikio, Nawa Akihiro, Nagasaka Tetsuro, Takikawa Osamu, Kikkawa Fumitaka

    CLINICAL CANCER RESEARCH   Vol. 14 ( 8 ) page： 2310 - 2317   2008.4

    　More details

  160. Gene directed enzyme prodrug therapy for ovarian cancer: Could GDEPT become a promising treatment against ovarian cancer?

    Nawa Akihiro, Tanino Tadatoshi, Luo ChenHong, Iwaki Masahiro, Kajiyama Hiroaki, Shibata Kiyosumi, Yamamoto Eiko, Ino Kazuhiko, Nishiyama Yukihiro, Kikkawa Fumitaka

    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY   Vol. 8 ( 2 ) page： 232 - 239   2008.2

    　More details

    Language：Japanese  

    Web of Science

  161. Gene directed enzyme prodrug therapy for ovarian cancer: could GDEPT become a promising treatment against ovarian cancer?

    Nawa A, Tanino T, Luo C, Iwaki M, Kajiyama H, Shibata K, Yamamoto E, Ino K, Nishiyama Y, Kikkawa F

    Anti-cancer agents in medicinal chemistry   Vol. 8 ( 2 ) page： 232 - 9   2008.2

    　More details

    Language：English  

    DOI： 10.2174/187152008783497000

    PubMed

  162. Angiotensin II mimics the hypoxic effect on regulating trophoblast proliferation and differentiation in human placental explant cultures

    Araki-Taguchi Masako, Nomura Seiji, Ino Kazuhiko, Sumigama Seiji, Yamamoto Eiko, Kotani-Ito Tomomi, Hayakawa Hiromi, Kajiyama Hiroaki, Shibata Kiyosumi, Itakura Atsuo, Kikkawa Fumitaka

    LIFE SCIENCES   Vol. 82 ( 1-2 ) page： 59 - 67   2008.1

    　More details

  163. Neuroendocrine tumor in the breast

    Ogawa Hiroshi, Nishio Akiko, Satake Hiroko, Naganawa Shinji, Imai Tsuneo, Sawaki Masataka, Yamamoto Eiko, Miyata Tomoko

    RADIATION MEDICINE   Vol. 26 ( 1 ) page： 28 - 32   2008.1

    　More details

  164. Twist expression in patients with cervical cancer is associated with poor disease outcome

    Shibata K., Kajiyama H., Ino K., Terauchi M., Yamamoto E., Nawa A., Nomura S., Kikkawa F.

    ANNALS OF ONCOLOGY   Vol. 19 ( 1 ) page： 81 - 85   2008.1

    　More details

  165. Establishment and characterization of an ovarian yolk sac tumor cell line reveals possible involvement of nkx2.5 in tumor development

    Shibata Kiyosumi, Kajiyama Hiroaki, Yamamoto Eiko, Terauchi Mikio, Ino Kazuhiko, Nawa Akihiro, Kikkawa Fumitaka

    ONCOLOGY   Vol. 74 ( 1-2 ) page： 104 - 111   2008

    　More details

  166. Expression of N-acetylglucosaminyltransferase V in endometrial cancer correlates with poor prognosis

    Yamamoto E., Ino K., Miyoshi E., Shibata K., Takahashi N., Kajiyama H., Nawa A., Nomura S., Nagasaka T., Kikkawa F.

    BRITISH JOURNAL OF CANCER   Vol. 97 ( 11 ) page： 1538 - 1544   2007.11

    　More details

  167. Involvement of oligosaccharide changes in alpha 5 beta 1 integrin in invasion of extravillous trophoblasts

    Yamamoto Eiko, Ino Kazuhiko, Kidokoro Kumiko, Takahashi Noriko, Yoshida Norio, Nakagawa Akiko, Sumigama Seiji, Kikkawa Fumitaka

    PLACENTA   Vol. 28 ( 10 ) page： A5 - A5   2007.10

    　More details

    Language：Japanese  

    Web of Science

  168. Possible involvement of TWIST in enhanced peritoneal metastasis of epithelial ovarian carcinoma

    Terauchi Mikio, Kajiyama Hiroaki, Yamashita Mamoru, Kato Mikihiko, Tsukamoto Hirohisa, Umezu Tomokazu, Hosono Satoyo, Yamamoto Eiko, Shibata Kiyosumi, Ino Kazuhiko, Nawa Akihiro, Nagasaka Tetsuro, Kikkawa Fumitaka

    CLINICAL & EXPERIMENTAL METASTASIS   Vol. 24 ( 5 ) page： 329 - 339   2007.9

    　More details

  169. A pure nongestational choriocarcinoma of the ovary diagnosed with short tandem repeat analysis: case report and review of the literature

    Yamamoto E., Ino K., Yamamoto T., Sumigama S., Nawa A., Nomura S., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 17 ( 1 ) page： 254 - U1   2007

    　More details

  170. Genetically identified complete hydatidiform mole coexisting with a live twin fetus: Comparison with conventional diagnosis

    Sumigama Seiji, Itakura Atsuo, Yamamoto Toshimichi, Nagasaka Tetsuro, Yamamoto Eiko, Ino Kazuhiko, Kikkawa Fumitaka

    GYNECOLOGIC AND OBSTETRIC INVESTIGATION   Vol. 64 ( 4 ) page： 228 - 231   2007

    　More details

  171. Involvement of oligosaccharide changes in 51 integrin in migration of extravillous trophoblasts

    Yamamoto E., Ino K., Sumigama S., Nomura S., Kikkawa F.

    PLACENTA   Vol. 28 ( 8-9 ) page： A61 - A61   2007

    　More details

    Language：Japanese  

    Web of Science

  172. Indoleamine 2,3-dioxygenase is a novel prognostic indicator for endometrial cancer

    Ino K., Yoshida N., Kajiyama H., Shibata K., Yamamoto E., Kidokoro K., Takahashi N., Terauchi M., Nawa A., Nomura S., Nagasaka T., Takikawa O., Kikkawa F.

    BRITISH JOURNAL OF CANCER   Vol. 95 ( 11 ) page： 1555 - 1561   2006.12

    　More details

  173. Endoplasmic reticulum aminopeptidase-1 mediates leukemia inhibitory factor-induced cell surface human leukocyte antigen-G expression in JEG-3 choriocarcinoma cells

    Shido F, Ito T, Nomura S, Yamamoto E, Sumigama S, Ino K, Itakura A, Hattori A, Tsujimoto M, Mizutani S, Kikkawa F

    ENDOCRINOLOGY   Vol. 147 ( 4 ) page： 1780 - 1788   2006.4

    　More details

  174. Angiotensin II type 1 receptor expression in ovarian cancer and its correlation with tumour angiogenesis and patient survival

    Ino K, Shibata K, Kajiyama H, Yamamoto E, Nagasaka T, Nawa A, Nomura S, Kikkawa F

    BRITISH JOURNAL OF CANCER   Vol. 94 ( 4 ) page： 552 - 560   2006.2

    　More details

  175. Twist expression predicts poor clinical outcome of patients with clear cell carcinoma of the ovary

    Kajiyama Hiroaki, Hosono Satoyo, Terauchi Mikio, Shibata Kiyosumi, Ino Kazuhiko, Yamamoto Eiko, Nomura Seiji, Nawa Akihiro, Kikkawa Fumitaka

    ONCOLOGY   Vol. 71 ( 5-6 ) page： 394 - 401   2006

    　More details

  176. Dual induction of indoleamine 2,3-dioxygenase and HLA-G by interferon-gamma in human extravillous trophoblasts: Its implication in tolerance at the fetal-maternal interface

    Ino K., Kidokoro K., Yamamoto E., Takahashi N., Yoshida N., Nomura S., Kikkawa F.

    PLACENTA   Vol. 27 ( 9-10 ) page： A29 - A29   2006

    　More details

    Language：Japanese  

    Web of Science

  177. The expression of N-acetylglucosaminyltransferase v in human placenta

    Yamamoto E., Mo K., Kidokoro K., Takahashi N., Nomura S., Kikkawa F.

    PLACENTA   Vol. 27 ( 9-10 ) page： A28 - A28   2006

    　More details

    Language：Japanese  

    Web of Science

  178. Sphingosine 1-phosphate and its receptors influence on trophoblast migration

    Sumigama Seiji, Kotani Tomomi, Yamamoto Eiko, Hayakawa Hiromi, Okada Mayumi, Kikkawa Fumitaka

    PLACENTA   Vol. 27 ( 9-10 ) page： A22 - A22   2006

    　More details

    Language：Japanese  

    Web of Science

  179. Expression of indoleamine 2,3-dioxygenase in human extravillous trophoblasts using first-trimester villous explant cultuers and the extravillous trophobalst cell line

    Kidokoro K., Ino K., Yamamoto E., Takahashi N., Yoshida N., Nomura S., Kikkawa F.

    PLACENTA   Vol. 27 ( 9-10 ) page： A28 - A28   2006

    　More details

    Language：Japanese  

    Web of Science

  180. Ikaros is expressed in human extravillous trophoblasts and involved in their migration and invasion

    Yamamoto E, Ito T, Abe A, Sido F, Ino K, Itakura A, Mizutani S, Dovat S, Nomura S, Kikkawa F

    MOLECULAR HUMAN REPRODUCTION   Vol. 11 ( 11 ) page： 825 - 831   2005.11

    　More details

  181. ADAM (a disintegrin and metalloproteinase)-12 mediate shedding of oxytocinase

    Nomura S, Ito N, Iwase A, Kidokoro K, Takahashi N, Yoshida N, Yamamoto E, Ito-Kotani T, Ino K, Kikkawa F

    PLACENTA   Vol. 26 ( 10 ) page： A8 - A8   2005.11

    　More details

    Language：Japanese  

    Web of Science

  182. Immunohistochemical expression of indoleamine 2,3-dioxygenase in gestational trophoblastic neoplasia

    Ino K, Yoshida N, Kidokoro K, Takahashi N, Yamamoto E, Nomura S, Kikkawa F

    PLACENTA   Vol. 26 ( 10 ) page： A5 - A5   2005.11

    　More details

    Language：Japanese  

    Web of Science

  183. Gene regulation and physiological function of placental leucine arninopeptidase/oxytocinase during pregnancy

    Nomura S, Ito T, Yamamoto E, Sumigama S, Iwase A, Okada M, Shibata K, Ando H, Ino K, Kikkawa F, Mizutani S

    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS   Vol. 1751 ( 1 ) page： 19 - 25   2005.8

    　More details

  184. Expression of indoleamine 2,3-dioxygenase (IDO) in neoplastic trophoblasts of gestational trophoblastic neoplasia.

    Ino K, Yamamoto E, Ito T, Kajiyama H, Shibata K, Nomura S, Kikkawa F

    PLACENTA   Vol. 26 ( 8-9 ) page： A37 - A37   2005

    　More details

    Language：Japanese  

    Web of Science

  185. Trnascriptional factor Ikaros-x might be involved in migratory and invasne ability in extravillous trophoblasts

    Yamamoto E, Ito T, Graham CH, Ino K, Nomura S, Kikkawa F

    PLACENTA   Vol. 26 ( 8-9 ) page： A61 - A61   2005

    　More details

    Language：Japanese  

    Web of Science

  186. Ikaros regulates invasiveness of human extravillous trophoblast

    Yamamoto E, Ito T, Shido F, Sumigama S, Nomura S, Kikkawa F

    PLACENTA   Vol. 25 ( 10 ) page： A2 - A2   2004.11

    　More details

    Language：Japanese  

    Web of Science

  187. The endoplasmic reticulum aminopeptidase, ERAP1 is involved in expression of membrane HLA-G and soluble HLA-G on trophoblast cells by leukemia inhibitory factor

    Shido F, Ito T, Nomura S, Yamamoto E, Sumigama S, Ino K, Itakura A, Mizutani S, Kikkawa F

    PLACENTA   Vol. 25 ( 10 ) page： A3 - A3   2004.11

    　More details

    Language：Japanese  

    Web of Science

  188. Oxytocinase gene regulation by AP-2alpha with trophoblast differentiation

    Nomura S, Ito T, Shido F, Yamamoto E, Ino K, Kikkawa F

    PLACENTA   Vol. 25 ( 10 ) page： A2 - A2   2004.11

    　More details

    Language：Japanese  

    Web of Science

  189. Placental leucine aminopeptidase/oxytocinase gene regulation by activator protein-2 in BeWo cell model of human trophoblast differentiation

    Iwanaga K, Nomura S, Ito T, Ikoma Y, Yamamoto E, Okada M, Itakura A, Kikkawa F, Tsujimoto M, Mizutani S

    FEBS LETTERS   Vol. 552 ( 2-3 ) page： 120 - 124   2003.9

    　More details

  190. Effects of postmenopausal hormone replacement therapy on HbA(1c) levels.

    Okada M, Nomura S, Ikoma Y, Yamamoto E, Ito T, Mitsui T, Tamakoshi K, Mizutani S

    Diabetes care   Vol. 26 ( 4 ) page： 1088 - 92   2003.4

    　More details

    Language：English  

    DOI： 10.2337/diacare.26.4.1088

    PubMed

  191. Effects of postmenopausal hormone replacement therapy on HbA(1c) levels

    Okada M, Nomura S, Ikoma Y, Yamamoto E, Ito T, Mitsui T, Tamakoshi K, Mizutani S

    DIABETES CARE   Vol. 26 ( 4 ) page： 1088 - 1092   2003.4

    　More details

    Language：Japanese  

    Web of Science

  192. Period shaming behavior among male students in Luang Prabang Province, Lao People's Democratic Republic: A cross-sectional study. International journal

    Souphalak Inthaphatha, Leyla Isin-Xiong, Viengsakhone Louangpradith, Valee Xiong, Vue Xaitengcha, Alongkone Phengsavanh, Kimihiro Nishino, Nobuyuki Hamajima, Eiko Yamamoto

    PloS one   Vol. 18 ( 7 ) page： e0288145   2023.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Period shaming is defined as any negative and/or disrespectful behavior in relation to the menstrual cycle and menstruating girls. It is suggested that period shaming may limit girls' potential and ability to fully participate in school and community activities. This study aims to examine the prevalence and factors associated with period shaming among male students in Luang Prabang Province, Lao People's Democratic Republic (Lao PDR). This was a cross-sectional study which was conducted during November 19-27, 2020. This study included 1,232 male students from secondary school grade 9 to 12 in Luang Prabang Province, Lao PDR. Informed consent was obtained from the participants, parents/guardians, and teachers prior to data collection. The data was collected by a self-administered questionnaire. Logistic regression was employed to examine factors associated with period shaming behavior among male students. The mean age of the participants was 16.4 years old. Of all the male students, 18.8% admitted that they had shamed girls during their menstruation at least once. Of those who committed period shaming, they shamed girls some of the times (63.2%). Male students who had consumed alcohol during the last month before the data collection day (AOR = 1.83, 95% CI 1.32-2.55, P<0.001), had heard of menstruation (AOR = 1.76, 95% CI 1.27-2.44, P<0.001), and those who had attended activities/classes about sexual reproductive health (AOR = 1.90, 95% CI 1.29-2.78, P<0.01), were significantly associated with period shaming behavior. In conclusion, a single focus on providing biological health education may not be enough to address menstrual stigmatization and taboos. The school curriculum should integrate other life skill education with reproductive health, such as respect and gender equality, to encourage behavioral changes among male students, to address menstrual stigma and to support and empower girls' menstrual health at school and in the community.

    DOI： 10.1371/journal.pone.0288145

    Web of Science

    PubMed

  193. Causes of death, three delays, and factors associated with Delay 1 among maternal deaths in Myanmar: The maternal death surveillance in 2019. International journal

    Khine Khine Tun, Souphalak Inthaphatha, Myint Moh Soe, Kimihiro Nishino, Nobuyuki Hamajima, Eiko Yamamoto

    Midwifery   Vol. 121   page： 103657 - 103657   2023.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVE: The maternal mortality ratio (MMR) in Myanmar was the highest in Southeast Asia in 2017. The Three Delay Model is used to evaluate delays that contribute to maternal deaths. This study aims to identify MMR, causes of death, the three delays related to maternal deaths, and the factors associated with Delay 1, which is the time of delay in deciding to seek health care (from the start of the woman's illness to the time when the problem is recognized to be requiring care), in Myanmar. STUDY DESIGN: A cross-sectional study. PARTICIPANT: This study included 934 cases of maternal deaths reported from all states and regions throughout Myanmar in 2019 that were not caused by accidents and injuries. MATERIALS AND METHODS: Socio-demographic factors, obstetrical factors, information about deaths, and assessment of delays were obtained from the Maternal Death Surveillance and Response System, the database of maternal deaths. Distribution of maternal deaths by states and regions, causes of maternal death, and types of delay that contributed to maternal deaths were descriptively summarized. Logistic regression analysis was performed to identify factors associated with Delay 1 among 567 maternal deaths without any missing data and unknown information on delays. FINDINGS: In 2019, the MMR was 106 (95% confidence interval, 99-112) per 100,000 live births. Of the 934 maternal deaths, 80.5% of deaths had at least one delay, and Delay 1 was the major delay (72.9%). Eclampsia/pre-eclampsia (21.6%), postpartum hemorrhage (18.2%), and abortion-related complications (13.2%) were the major causes of maternal death. The husband's low education, low household income, unplanned pregnancy, and no antenatal care were associated with Delay 1. KEY CONCLUSIONS AND IMPLICATION FOR PRACTICE: The MMR was lower in 2019 than that in 2017 but remained high. Moreover, we demonstrate that most maternal deaths had at least one delay, mostly Delay 1. To prevent maternal deaths caused by Delay 1, the family planning should be promoted to prevent unplanned pregnancies. Educational training for healthcare providers who deliver antenatal care should be strengthened. Furthermore, education on the danger signs of pregnancy and during childbirth should be provided not only to pregnant women and their husbands in communities at health facilities.

    DOI： 10.1016/j.midw.2023.103657

    Web of Science

    PubMed

  194. Assessment of the underlying causes of adult deaths using a short version of verbal autopsy in Xaiyabouli Province, Lao People's Democratic Republic. International journal

    Bounbouly Thanavanh, Nobuyuki Hamajima, Kaiyason Sida, Kene Duangdy, Lasavong Latsamy, Khounsavath Senaphane, Viengsakhone Louangpradith, Souphaphone Sadettan, Souphalak Inthaphatha, Kimihiro Nishino, Eiko Yamamoto

    BMC public health   Vol. 23 ( 1 ) page： 560 - 560   2023.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: In developing countries, it is difficult to collect the data of the underlying cause of death (UCOD), especially when a death does not occur in a health facility. This study aimed to develop a short version of verbal autopsy (VA) and identify the UCOD of adults in Lao People's Democratic Republic (Lao PDR). METHODS: A short version of VA for deaths outside health facilities was developed. This study included all deaths of people aged 15 years old or older in Xaiyabouli Province in 2020. Socio-demographic factors, place of death, and UCOD of the deceased were collected from health facilities or from family members using a questionnaire including the short VA form. UCOD was compared between home deaths and hospital deaths, between the age group of 15-59 years old and the age group ≥ 60 years old, and between males and females. RESULTS: Of all the 1,235 deaths included in this study, 1,012 deaths (81.9%) occured at home and 223 deaths (18.1%) at hospitals. The most common UCOD was senility (13.3%), followed by heart/renal failure (10.5%), pneumonia (9.6%) and traffic accident (7.1%). Compared to hospital deaths, home deaths had more people who were females, 75 years old or older, and Lao-Tai. Home deaths had more deaths than hospital deaths due to accident/injury (16.0% vs. 8.1%), tumor (4.7% vs. 1.8%), and senility (16.2% vs. 0%); fewer deaths due to heart/renal disease (15.1% vs. 32.3%), respiratory disease (12.2% vs. 18.8%), liver/gastro-intestine disease (5.3% vs. 9.0%), and infection (3.1% vs. 14.3%). The age group of 15-59 years had more deaths in the categories of accident/injury (28.1% vs. 4.4%), liver/gastro-intestine disease (8.1% vs. 4.4%), infection (7.2% vs. 3.5%), and tumor (6.0% vs. 2.8%). Males had more deaths due to tumor (5.2% vs. 3.0%) and fewer natural deaths (11.2% vs. 15.9%) than females. CONCLUSIONS: The major UCOD category was heart/renal disease in the adult generation in Xaiyabouli Province. Cost-effective interventions based on the multisectoral noncommunicable disease prevention plan should be appropriately implemented. Mortality surveillance using the short VA tool should be conducted for all home deaths in Lao PDR.

    DOI： 10.1186/s12889-023-15469-2

    Web of Science

    PubMed

  195. Reporting system on mortality statistics in Lao People's Democratic Republic.

    Souphalak Inthaphatha, Viengsakhone Louangpradith, Bounfeng Phoummalaysith, Bounbouly Thanavanh, Tetsuyoshi Kariya, Eiko Yamamoto, Nobuyuki Hamajima

    Nagoya journal of medical science   Vol. 85 ( 1 ) page： 113 - 122   2023.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    The system to collect information on mortality statistics in Lao PDR is not well established, accurate and timely death information is therefore not available. This article reports the system and process to make the mortality statistical data of Lao PDR. The country has a paper-based resident registration system, using a death notification document, a death certificate, and a family census book. The death notification document is important as it provides the cause of death, which is issued from a health facility and the village office. In the event of a death occurring at home, the family representative needs to report to the village office verbally to obtain a death notification document. On the other hand, if the death occurred in a medical facility, a death notification document from a health facility is provided. The family representative should bring the death notification document to the district Home Affairs office to register the death and obtain a death certificate. After that, the family representative needs to bring the death certificate to the district Public Security office for an amendment in the family census book. ICD-10 is under development regarding death notification from health facilities under the Ministry of Health. However, it is unclear how death notification from village offices can adopt ICD-10 as the majority of deaths occur outside health facilities. A comprehensive and integrated mortality reporting system is necessary in order to create a holistic health policy and welfare for the country.

    DOI： 10.18999/nagjms.85.1.113

    Web of Science

    PubMed

  196. Factors associated with positive cancer screening for the uterine cervix and breast in Jakarta Province, Indonesia: a cross-sectional study. International journal

    Lady Margaretha Febriany Sirait, Nobuyuki Hamajima, Yunosuke Suzuki, Endang Sri Wahyuningsih, Dwi Oktavia, Widyastuti, Souphalak Inthaphatha, Kimihiro Nishino, Eiko Yamamoto

    BMC cancer   Vol. 22 ( 1 ) page： 1309 - 1309   2022.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: In many middle-income countries, cancer incidence and mortality are rapidly increasing, but data for developing a strategy of cancer control are rarely collected or analyzed. This study aimed to identify factors associated with positive cancer screening for the uterine cervix and breast in Jakarta Province, Indonesia. METHODS: The data of 79,660 women who had visual inspection with acetic acid (VIA) and 83,043 women who had clinical breast examination (CBE) in the Jakarta Women Cancer Screening program in 2019 were included in this study. Socio-demographic factors, reproductive factors, lifestyle factors, family history, and the results of VIA and CBE were used for analyses. Binary and multivariate logistic regression analyses were performed to identify factors associated with VIA positive or CBE positive. RESULTS: The positive rate was 0.9% for both VIA and CBE among the screening participants. Factors associated with VIA positive were age < 30 years old, age at menarche ≤ 11 years old, remarriage, lower educational level, having an occupation, partner's occupation other than being an employee, alcohol consumption, smoker, inadequate physical activity, cancer family history, and no Pap smear history. Factors associated with CBE positive were age at menarche ≤ 11 years old, widowed, high education, having an occupation, no breastfeeding history, birth control history, alcohol consumption, smoker, inadequate physical activity, cancer family history, and breast tumor history. CONCLUSION: Factors associated with VIA positive and CBE positive among Indonesian women were revealed. To promote female cancer prevention in Indonesia, the prevalence of screenings should be increased and education about the risk factors should be provided to medical professionals.

    DOI： 10.1186/s12885-022-10381-1

    Web of Science

    PubMed

  197. Epidemiologic study on gestational trophoblastic diseases in Japan. International journal

    Eiko Yamamoto, Kimihiro Nishino, Kaoru Niimi, Kazuhiko Ino

    Journal of gynecologic oncology   Vol. 33 ( 6 ) page： e72   2022.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVE: This study aims to estimate the population-based incidence of gestational trophoblastic diseases (GTDs) and to identify the characteristics of gestational trophoblastic neoplasia (GTN) in Japan. METHODS: The annual number of GTD and live births from 1974 to 2018 were used to estimate the incidence of GTD. The data of 1,574 GTN cases from 1999 to 2018 were analyzed to identify the characteristics of low-risk GTN, high-risk GTN, placental site trophoblastic tumor (PSTT), and epithelioid trophoblastic tumor (ETT). RESULTS: The incidence of hydatidiform mole was 2.02 per 1,000 live births on average which decreased from 1974 to 2008 and increased from 2009 to 2018. The incidence of low-risk GTN, high-risk GTN, PSTT, and ETT was 15.3, 3.5, 0.3, and 0.07 per 100,000 live births, respectively. The estimated incidence of post-molar GTN was 9.8% of molar patients. High-risk GTN was diagnosed more pathologically, had more various kinds of antecedent pregnancies, and had longer intervals after the antecedent pregnancy compared to low-risk GTN. Furthermore, 8.2% of high-risk GTN occurred after the subsequent non-molar pregnancy of hydatidiform mole. The cumulative percentage of developing high-risk GTN after hydatidiform mole reached 89.3% at the 60th month. CONCLUSION: The incidence of hydatidiform mole, low-risk GTN, high-risk GTN was 2.02 per 1,000 live births, 15.3 per 100,000 live births, and 3.5 per 100,000 live births, respectively. High-risk GTN was diagnosed more pathologically and later after the antecedent pregnancy than low-risk GTN. Following molar patients for five years is needed to improve the mortality of malignant GTN.

    DOI： 10.3802/jgo.2022.33.e72

    PubMed

  198. Children with neuro-developmental disorders at Center for Child and Adolescent Mental Health in Cambodia.

    Sreyleap Moeun, Jegannathan Bhoomikumar, Puthy Pat, Tetsuyoshi Kariya, Yunosuke Suzuki, Nobuyuki Hamajima, Dearozet Sok, Eiko Yamamoto

    Nagoya journal of medical science   Vol. 84 ( 3 ) page： 593 - 606   2022.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    The Center for Child and Adolescent Mental Health (CCAMH) is one of the centers that have psychiatric specialists for children in Cambodia. This study aims to understand the characteristics of children with neuro-developmental disorders, especially autism spectrum disorder (ASD), at CCAMH. This study included 440 cases that were randomly chosen from 2,147 new patients at CCAMH in 2018-2019 and were aged 0-12 years. Socio-demographic factors, parent's information, obstetrical factors, and clinical data were collected from patients' records. A logistic regression analysis and Pearson's chi-square test were used to compare the characteristics between children who were finally diagnosed with ASD and the others (non-ASD). Of the 440 patients, most were male (75.2%), 0-4 years old (57.7%), and diagnosed with ASD (50.0%). Common symptoms were delay of speech, playing alone, and hyperactivity. ASD was significantly more prevalent in male patients compared to females and in the 0-4 years age group compared to the 5-12 years age group. Parents who lived in Phnom Penh and had high education were more likely to visit the CCAMH with their children who were diagnosed with ASD. Regarding treatment, approximately half of all 440 patients had family counselling and psychosocial education. ASD patients had more speech therapy, special education and structured teaching, and networking and coordination therapy compared to non-ASD patients. To provide education and therapy to children with ASD and their parents from the early stage, information about the center and ASD should be widely distributed to all parents in Cambodia.

    DOI： 10.18999/nagjms.84.3.593

    Web of Science

    PubMed

  199. Development of a Vietnamese version of the Revised Hasegawa's Dementia scale.

    Thi Phuong Tran, Duy Cuong Nguyen, Thi Van Quy Dang, Thi Khuyen Tran, Phong Tuc Vu, Minh Hoang Vu, Thu Hang Le, Thu Nandar Saw, Su Myat Cho, Tetsuyoshi Kariya, Eiko Yamamoto, Nobuyuki Hamajima, Yu Mon Saw

    Nagoya journal of medical science   Vol. 84 ( 2 ) page： 402 - 417   2022.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    As the aging population grows worldwide, the problem of age-related health is becoming an important public health concern. Dementia is a devastating disease that places a significant physical, emotional, and financial burden on patients, their caregivers, and society. It is predicted to increase in developing countries. The Revised Hasegawa's Dementia Scale (HDS-R) has been used in many Asian countries to measure cognitive function. However, there is still no Vietnamese version of the HDS-R. Therefore, this paper describes the development of the HDS-R scale and manual in Vietnamese language. Two Vietnamese researchers translated the HDS-R from English to Vietnamese. To confirm the accuracy of the translation, two other Vietnamese researchers conducted a back-translation. Another pair of Vietnamese researchers compared the back-translated English version to the original one. All six researchers discussed the inconsistencies between English HDS-R scale and manual and derived the most suitable version for the Vietnamese context. In Questions 4 and Question 7, we changed the words from "cherry blossom" and "train" to "daisy flower" and "bicycle" for the first option, and from "plum blossom" to "rose" for the second option. We also changed the expressions in some places in the manual to fit the Vietnamese language. Future studies are needed to validate this version to be able to access cognitive function in both clinical and public healthcare settings.

    DOI： 10.18999/nagjms.84.2.402

    Web of Science

    PubMed

  200. Underlying cause of death at medical facilities in Xaiyabouli Province, Lao People's Democratic Republic.

    Bounbouly Thanavanh, Singkham Hackpaserd, Souphalak Inthaphatha, Tetsuyoshi Kariya, Yunosuke Suzuki, Eiko Yamamoto, Nobuyuki Hamajima

    Nagoya journal of medical science   Vol. 84 ( 2 ) page： 448 - 461   2022.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    In Lao PDR, Ministry of Health introduced District Health Information Software 2 (DHIS2) in 2013. Although DHIS2 includes cause of death, Lao government did not request to report cause of death through DHIS2, resulting in no information on frequency of underlying cause of death even for the deaths at medical facility. This study aimed to collect the information on the underlying cause of death at all medical facilities in Xaiyabouli province, a rural area in Lao PDR. As well as the point estimate of the proportion, a 95% confidence interval (CI) based on a binomial distribution was calculated for each cause of death. According to the local government request, 226 deaths (128 males and 98 females) in 2019 were reported from all medical facilities in the province. Among them, infectious diseases were the most frequent (33.6%, 95% CI 27.5-40.2%); sepsis (16.8%, 95% CI 12.2-22.3%), pneumonia (8.8%, 95% CI 5.5-13.3%), and meningitis (4.9%, 95% CI 2.5-8.5%). Heart diseases were 15.9% (95% CI 11.4-21.4%) including heart failure and myocardial infarction. Injury was 10.2% (95% CI 6.2-14.4%) including brain injury. Neonatal death was 10.6% (95% CI 6.9-15.4%). Among those, preterm death was common (8.8%, 95% CI 5.3-13.3%). Renal failure was 8.0% (95% CI 4.8-12.3%). According to civil registration covering all deaths both at facilities and outside facilities, deaths at facilities were 16.8% of the whole deaths (1,372 deaths) in Xaiyabouli province. Although deaths outside facilities were not included, this is the first report demonstrating cause of death in one province in Lao PDR.

    DOI： 10.18999/nagjms.84.2.448

    Web of Science

    PubMed

  201. Patient delay and health system delay of patients with newly diagnosed pulmonary tuberculosis in Mongolia, 2016-2017.

    Batmunkh Batbayar, Tetsuyoshi Kariya, Tsolmon Boldoo, Enkhtamir Purevdorj, Naranzul Dambaa, Yu Mon Saw, Eiko Yamamoto, Nobuyuki Hamajima

    Nagoya journal of medical science   Vol. 84 ( 2 ) page： 339 - 351   2022.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Although diagnosis and treatment of tuberculosis (TB) have been improved in many countries, delays in the diagnosis and treatment remain problematic in resource-limited countries. This study aimed to identify factors affecting delays in TB care in Mongolia. Data on TB cases registered from January 2016 to December 2017 were obtained from the national registry of TB at the Department of TB Surveillance and Research in National Center for Communicable Disease. The total number of TB cases registered in these two years was 8,166, including 3,267 cases of newly diagnosed pulmonary TB. Pulmonary TB cases (1,836 males and 1,431 females) were analyzed to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs). Patient delays longer than the median (28 days) were significantly associated with patient age >32 years (aOR=1.31, 95%CI: 1.14-1.51), residence in areas other than Ulaanbaatar (aimags) (aOR=1.38, 95%CI: 1.20-1.59), and smear-negative (aOR=0.57, 95%CI: 0.47-0.69). Health system delays longer than the median (7 days) were significantly associated with patient age >32 years (aOR=1.16, 95%CI: 1.00-1.33), residence in aimags (aOR=0.82, 95%CI: 0.71-0.95), special facilities including a prison hospital (aOR=4.40, 95%CI: 2.42-7.83), registration in 2017 relative to 2016 (aOR=0.83, 95%CI: 0.71-0.95), and smear-negative (aOR=1.72, 95%CI: 1.42-2.07). Total delays longer than the median (45 days) were significantly associated with patient age >32 years (aOR=1.39, 95%CI: 1.21-1.60), residence in aimags (aOR=1.27, 95%CI: 1.11-1.47), and smear-negative (aOR=0.74, 95%CI: 0.62-0.90). To shorten the total delay, improvement of the access to medical facilities in aimags is necessary.

    DOI： 10.18999/nagjms.84.2.339

    Web of Science

    PubMed

  202. Pregnancy Outcomes in Women with Thyroid Diseases

    Kotani Tomomi, Imai Kenji, Ushida Takafumi, Moriyama Yoshinori, Nakano-Kobayashi Tomoko, Osuka Satoko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Kinoshita Fumie, Hirakawa Akihiro, Iwase Akira, Kikkawa Fumitaka, Kajiyama Hiroaki

    JMA Journal   Vol. 5 ( 2 ) page： 216 - 223   2022.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japan Medical Association / The Japanese Associaiton of Medical Sciences  

    <p><b>Introduction:</b> Overt hyperthyroidism and hypothyroidism are associated with pregnancy complications; however, most women with these conditions are diagnosed before conception and are under treatment during pregnancy, especially in high-income countries. The purpose of this study was to investigate pregnancy complications among these women.</p><p><b>Methods:</b> A retrospective cohort study was conducted, and data on pregnant women who gave birth to a singleton at Nagoya University Hospital in Japan in 2005-2014 was collected. The pregnancy outcomes were divided and compared among three groups: the control group (n = 3531), the hyperthyroidism group (n = 48), and the hypothyroidism group (n = 61). Additionally, risk factors for placental abruption were evaluated by multivariable logistic regression analysis. Moreover, in hyperthyroidism, thyroid function at the placentation period was compared between placental-related diseases and nonplacental-related disease groups, and the latter group included placental abruption and preeclampsia.</p><p><b>Results:</b> The incidence of placental abruption was higher in hyperthyroidism than in control and hypothyroidism groups. Hyperthyroidism was independently associated with an increased risk of placental abruption (adjusted odds ratio, aOR = 8.21, 95% confidence interval, CI: 1.76-38.34), as well as preeclampsia (aOR = 4.10, 95% CI: 1.13-14.76) and preterm labor (aOR = 3.38, 95% CI: 1.19-9.64). Additionally, thyroid-stimulating hormone (TSH) at the placentation period was significantly lower in the placental-related disease group than in the nonplacental-related disease group (<i>p</i> < 0.05).</p><p><b>Conclusions:</b> Pregnancy outcomes in women with hyperthyroidism and hypothyroidism would be comparable with those without thyroid disease. Hyperthyroidism was an independent risk factor for placental abruption as well as preterm labor and preeclampsia. However, its frequency was extremely low, and further research is required to validate our findings.</p>

    DOI： 10.31662/jmaj.2021-0191

    PubMed

    CiNii Research

  203. 絨毛癌の免疫微小環境の解明 NK細胞抑制型受容体に着目して

    柴田 真由, 新美 薫, 服部 諭美, 西子 裕規, 小田 結加里, 渡邉 絵里, 横井 暁, 西野 公博, 山本 英子, 梶山 広明

    日本産科婦人科学会雑誌   Vol. 74 ( 臨増 ) page： S - 338   2022.2

    　More details

    Language：Japanese   Publisher：(公社)日本産科婦人科学会  

  204. 絨毛癌MTX耐性株の作成と解析

    西子 裕規, 新美 薫, 横井 暁, 吉田 康将, 柴田 真由, 小田 結加里, 渡邉 絵里, 西野 公博, 山本 英子, 梶山 広明

    日本産科婦人科学会雑誌   Vol. 74 ( 臨増 ) page： S - 512   2022.2

    　More details

    Language：Japanese   Publisher：(公社)日本産科婦人科学会  

  205. Cell surface membrane lysosome-associated membrane glycoprotein 2 promotes cell adhesion via abundant N-glycans in choriocarcinoma. International journal

    Kimihiro Nishino, Yuki Nishiko, Mayu Shibata, Yukari Oda, Eri Watanabe, Kaoru Niimi, Eiko Yamamoto, Hiroaki Kajiyama

    Placenta   Vol. 117   page： 109 - 117   2022.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    INTRODUCTION: Lysosome-associated membrane glycoprotein 2 (LAMP-2) is a target protein for glycosylation by N-acetylglucosaminyltransferase IV (GnT-IV), which catalyzes the formation of β1,4GlcNAc branches on the mannose core of N-glycans in choriocarcinoma cells. However, the role of LAMP-2, especially when it is expressed in the cell surface membrane of choriocarcinoma cells, has not been well investigated in the progression of choriocarcinoma. This study aimed to elucidate the function of the cell surface membrane LAMP-2 in the malignancy of choriocarcinoma. METHODS: We evaluated the localization of LAMP-2 in some choriocarcinoma cell lines and clinical samples of choriocarcinoma, normal placenta, hydatidiform mole, and invasive mole by flow cytometry, immunocytochemistry, and immunohistochemistry. We performed functional experiments using the knockout or overexpression model of LAMP-2 in the presence or absence of galectins. RESULTS: LAMP-2 was observed in the cell surface membrane of some choriocarcinoma cell lines and tumor cells of choriocarcinoma tissue and trophoblasts of the placenta, hydatidiform mole, and invasive mole. Cell surface membrane LAMP-2 knockout decreased cell adhesion and invasion in choriocarcinoma cells. Conversely, cell surface membrane LAMP-2A overexpression increased cell adhesion and invasion. Experiments in the presence of galectins revealed that abundant N-glycans bound to the peptide core of the luminal side of the cell surface membrane LAMP-2 mediated cell adhesion of choriocarcinoma cells by interacting with galectins in the extracellular matrix (ECM). DISCUSSION: Cell surface membrane LAMP-2, which is glycosylated by GnT-IV, contributes to the malignancy of choriocarcinoma by promoting cell adhesion with the ECM via abundant N-glycans.

    DOI： 10.1016/j.placenta.2021.11.005

    Web of Science

    PubMed

  206. Factors associated with severe dengue in Savannakhet Province, Lao People's Democratic Republic.

    Phetvilay Senavong, Eiko Yamamoto, Phouvilay Keomoungkhoune, Nouda Prasith, Virasack Somoulay, Tetsuyoshi Kariya, Yu Mon Saw, Tiengkham Pongvongsa, Nobuyuki Hamajima

    Nagoya journal of medical science   Vol. 83 ( 4 ) page： 749 - 763   2021.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    This study aimed to describe the socio-demographic and clinical characteristics of dengue inpatients at a provincial hospital, and to identify factors associated with severe dengue. This is a retrospective study involving 402 dengue patients admitted to the Savannakhet Provincial Hospital, Lao People's Democratic Republic (Lao PDR), between January 2018 and April 2019. Socio-demographic factors, clinical signs and laboratory data on admission, final diagnosis, use of health care services before admission, admission date, and hospitalization period were collected from patient records. The number of dengue inpatients was higher in the rainy season than in the dry season. Of the 402 patients, 205 patients (51.0%) were finally diagnosed with severe dengue. Children aged <15 years had more symptoms, higher proportion of severe dengue (69.8% vs. 35.9%), and longer hospitalization (3.5 days vs. 3.0 days) than adults aged ≥15 years. In multivariable analyses, factors associated with severe dengue were nausea on admission (adjusted odds ratio=3.57, 95% CI=1.05-12.09, P=0.04) in children and persistent vomiting on admission (adjusted odds ratio=3.82, 95% CI=1.23-11.92, P=0.02) in adults. In adults, the creatinine level on admission was significantly higher in patients with a final diagnosis of severe dengue compared to the others. The proportion of severe dengue in our study was higher than that in other countries. Nausea and persistent vomiting on admission were suggested to be predictive factors for severe dengue. To reduce the incidence of severe dengue in Lao PDR, improvements in access to health care, referral system, and training of health care workers are needed.

    DOI： 10.18999/nagjms.83.4.749

    Web of Science

    PubMed

  207. The current situation of health services for hydatidiform mole in Cambodia. International journal

    Eiko Yamamoto, Koum Kanal, Sann Chan Soeung, Noriko Fujita, Sidonn Krang, Puthik Long-Hay, Kimihiro Nishino, Kaoru Niimi, Nobuyuki Hamajima

    The journal of obstetrics and gynaecology research   Vol. 47 ( 10 ) page： 3652 - 3660   2021.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    AIM: Management of hydatidiform mole is important to reduce the mortality and morbidity of choriocarcinoma. This study aims to understand the existing health services for hydatidiform mole and to estimate the incidence of gestational trophoblastic disease (GTD) in Cambodia. METHODS: A questionnaire was used to collect information on the existing health services for pregnancy and hydatidiform mole at health facilities from attendants of the 16th Annual Conference of the Cambodian Society of Gynecology and Obstetrics in 2017. The incidence of GTD in 2014-2017 was estimated using Health Information System data. RESULTS: A total of 126 attendants, who were from all provinces except three provinces, answered the questionnaire. The work places were national hospitals (n = 29), provincial hospitals (n = 42), district hospitals (n = 20), health centers (n = 6), and others (n = 29). The answers of participants from the public sector suggested the following: Ultrasonography is available at all hospitals but not health centers; Human chorionic gonadotropin (hCG) measurement is only available at national hospitals; Treatment of hydatidiform mole is performed at national hospitals and provincial hospitals; and Treatment of gestational trophoblastic neoplasia (GTN) is provided at national hospitals. The incidence of hydatidiform mole and GTN at health facilities in the public sector in 2014-2017 was 0.95 per 1000 deliveries and 6.58 per 100 000 deliveries, respectively. CONCLUSIONS: The results suggest that provincial hospitals are important to detect suspected invasive mole and refer to national hospitals for diagnosis and treatment. Further studies on the management of GTD and development of the guidelines of GTD are needed.

    DOI： 10.1111/jog.14955

    Web of Science

    PubMed

  208. Short tandem repeat analysis to identify the causative pregnancy of high-risk gestational trophoblastic neoplasia: Molar versus nonmolar pregnancy and its relation to the outcome. International journal

    Kimihiro Nishino, Eiko Yamamoto, Yukari Oda, Eri Watanabe, Kaoru Niimi, Toshimichi Yamamoto, Hiroaki Kajiyama

    Placenta   Vol. 112   page： 28 - 35   2021.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    INTRODUCTION: Gestational trophoblastic neoplasia (GTN) include a group of malignant neoplasms that originate from the trophoblasts of placental tissue in molar or nonmolar pregnancy. Currently, it is unclear whether the prognosis of high-risk GTN or gestational choriocarcinoma succeeding molar pregnancy or that following a nonmolar one is better. Comparison of the genetic short tandem repeat (STR) patterns of the DNA extracted from the tumor, patient, and her partner allows the genetic origins of the choriocarcinoma to be distinguished - whether it is gestational or non-gestational and whether it is derived from a molar or nonmolar pregnancy in the event it is gestational. This study aimed to investigate the causative pregnancy of patients with high-risk GTN, especially those with poor outcomes, and assess the impact of the causative pregnancy on patient outcome. METHODS: We evaluated 24 patients who were diagnosed with high-risk GTN between January 2000 and October 2019, including 15 cases of pathologically proven gestational choriocarcinomas and the causative pregnancy was investigated by STR analysis in which tumor DNA could be extracted. RESULTS: In high-risk GTN without history of anteceding molar pregnancies, nonmolar pregnancy was the causative pregnancy, which was confirmed in three cases. Molar pregnancy appeared be the causative pregnancy of high-risk GTN in patients with a history of antecedent molar pregnancies either with or without interruption by subsequent nonmolar pregnancies prior to developing high-risk GTN. High-risk GTN in most of the evaluated deceased cases (three of four) was due to nonmolar pregnancy, while all but one case with molar pregnancy as the causative pregnancy survived. DISCUSSION: STR analysis can distinguish the causative pregnancy of high-risk GTN, and nonmolar pregnancy as the causative pregnancy might have negative effects on the outcome of the disease.

    DOI： 10.1016/j.placenta.2021.06.015

    Web of Science

    PubMed

  209. Core 2 β1,6-N-acetylglucosaminyltransferases accelerate the escape of choriocarcinoma from natural killer cell immunity. International journal

    Kenichi Nakamura, Kaoru Niimi, Eiko Yamamoto, Yoshiki Ikeda, Kimihiro Nishino, Shiro Suzuki, Hiroaki Kajiyama, Fumitaka Kikkawa

    Biochemistry and biophysics reports   Vol. 26   page： 100951 - 100951   2021.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Hyperglycosylated human chorionic gonadotropin (H-hCG) is secreted from choriocarcinoma and contains a core2 O-glycan formed by core2 β1,6-N-acetylglucosaminyl transferase (C2GnT). Choriocarcinoma is considered immunogenic as it is gestational and contains paternal chromosomal components. Here we examined the function of C2GnT in the evasion of choriocarcinoma cells from natural killer (NK) cell-mediating killing. We determined that C2GnT is highly expressed in malignant gestational trophoblastic neoplasms. C2GnT KO downregulates core2 O-glycan expression in choriocarcinoma cells, which are more efficiently killed by NK cells than control cells. C2GnT KO cell containing tumor necrosis factor-related apoptosis inducing ligand have lower viability than control cells. Additionally, poly-N-acetyllactosamine in core2 branched oligosaccharides on MHC class I-related chain A (MICA) and mucin1 (MUC1) is significantly reduced in C2GnT KO cells. Meanwhile, the cumulative survival rate of nude mice inoculated with C2GnT KO tumors was higher than that of the control group. These findings suggest that choriocarcinoma cells may escape NK cell-mediated killing via glycosylation of MICA and MUC1.

    DOI： 10.1016/j.bbrep.2021.100951

    Web of Science

    PubMed

  210. Next-generation genome sequencing of a matched normal-tumor pair from a patient with intractable gestational choriocarcinoma: A case report. International journal

    Kaoru Niimi, Eiko Yamamoto, Sachi Morita, Maki Morikawa, Hikaru Hattori, Miki Hatakeyama, Mami Morita, Kimihiro Nishino, Yukari Oda, Eri Watanabe, Toshimichi Yamamoto, Hiroaki Kajiyama, Fumitaka Kikkawa

    Molecular and clinical oncology   Vol. 15 ( 1 ) page： 143 - 143   2021.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Gestational choriocarcinoma is a gestational trophoblastic neoplasia (GTN) originating from trophoblastic cells with abnormal proliferation. Although chemotherapy is effective for treating this cancer, when patients develop chemoresistance, personalized treatment, such as the use of drugs matching their genomes, is required. The present report describes a case of intractable gestational choriocarcinoma identified using a next-generation sequencing (NGS)-based tumor panel. A 51-year-old woman was diagnosed with gestational choriocarcinoma via pathological and short tandem repeat analyses. The patient did not achieve remission despite many regimens of chemotherapy, including high-dose therapy with autologous peripheral blood stem cell transplantation. To identify drugs tailored to this particular choriocarcinoma, NGS was performed on the tumor of the patient, and the tumor genome was compared with that of the patient's blood sample using the NCC Oncopanel System. Consequently, 245 single nucleotide variants (SNVs) with a mean SNV allele frequency of 63.1% were identified. This high frequency was because the genome of the gestational choriocarcinoma contained part of the genome of the partner. Therefore, our experience of the present intractable case of choriocarcinoma suggested that matched normal-tumor pair analysis is not appropriate for treatment decisions in GTN cases. When using an NGS-based tumor panel to assess choriocarcinoma, researchers must consider whether the genomic DNA of the patient and their partner are involved in the GTN.

    DOI： 10.3892/mco.2021.2305

    Web of Science

    PubMed

  211. Assessment of myocardial performance index in late-onset fetal growth restriction.

    Tran Thao Nguyen Nguyen, Tomomi Kotani, Kenji Imai, Takafumi Ushida, Yoshinori Moriyama, Tomoko Kobayashi, Kaoru Niimi, Seiji Sumigama, Eiko Yamamoto, Van Duc Vo, Minh Tam Le, Lam Huong Le, Dac Nguyen Nguyen, Vu Quoc Huy Nguyen, Quang Vinh Truong, Ngoc Thanh Cao, Fumitaka Kikkawa

    Nagoya journal of medical science   Vol. 83 ( 2 ) page： 259 - 268   2021.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    The aim of this study is to determine whether the myocardial performance index (MPI) is increased in fetal growth restriction (FGR) fetuses and if increased MPI is related to adverse outcomes of FGR. This is a prospective cross-sectional study. Seventy-three late-onset FGR fetuses and 97 gestational-age matched control fetuses were enrolled in this study. Fetal blood flow parameters including MPI values were measured and compared between the two groups. For the effect of severity of growth restriction on MPI value, they were also compared with < 3rd and 3rd - 10th centile groups. FGR fetuses were divided into two groups by favorable and adverse outcome and ultrasound parameters were compared between these two groups. Moreover, significant factors related to adverse outcomes by univariate analysis were analyzed by multivariate logistic regression analysis. Pulsatility index of umbilical arterial flow (UA-PI), MPI and amniotic fluid index in the FGR were significantly different from the control fetuses. However, no significant difference between < 3rd and 3rd - 10th centile groups was detected in MPI and UA-PI. The increased levels of MPI and UA-PI were independently related with adverse outcome of late-onset FGR pregnancy. In conclusion, MPI values were increased in late-onset FGR pregnancy, and the higher level of MPI could predict adverse outcome as well as the measurement of UA-PI. Clinicians should consider cardiac dysfunction in FGR through increased MPI.

    DOI： 10.18999/nagjms.83.2.259

    Web of Science

    PubMed

  212. A poor prognostic metastatic nongestational choriocarcinoma of the ovary: a case report and the literature review. International journal

    Kimihiro Nishino, Eiko Yamamoto, Yoshiki Ikeda, Kaoru Niimi, Toshimichi Yamamoto, Hiroaki Kajiyama

    Journal of ovarian research   Vol. 14 ( 1 ) page： 56 - 56   2021.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Pure ovarian choriocarcinoma can be gestational or nongestational in origin. Nongestational pure ovarian choriocarcinoma is extremely rare and the prognosis is thought to be worse than that of the gestational type in patients with metastatic disease. We present a case of metastatic pure ovarian choriocarcinoma with poor prognosis in which the origin was identified as nongestational by DNA short tandem repeat (STR) analysis. CASE PRESENTATION: A nulliparous woman in her thirties with metastatic choriocarcinoma was referred to our hospital after initial treatment proved unsuccessful. Two months earlier, she had undergone brain tumor resection and histological examination confirmed choriocarcinoma. Serum human chorionic gonadotropin (hCG) concentration at initial diagnosis was 5030 IU/L. Two cycles of a combination chemotherapy regimen of methotrexate, etoposide, and actinomycin-D (MEA therapy), which is commonly used for gestational choriocarcinoma, was administered. However, the disease could not be controlled. Imaging modalities at presentation revealed tumor present in the left ovary and left lung, but not in the uterus, which led us think that the choriocarcinoma was nongestational. Bleomycin, etoposide, and cisplatin (BEP therapy) which is commonly used for nongestational choriocarcinoma (malignant germ cell tumor) and surgical resection of the uterus, bilateral ovaries, and an affected part of the left lung led to the nadir level of hCG, but the tumor relapsed and levels of hCG again increased. To investigate the origin of choriocarcinoma, we performed DNA STR analysis of tumor cells and oral mucosal cells. Analysis revealed the origin of the choriocarcinoma as nongestational, as the genotype of tumor cells entirely corresponded with that of oral mucosal cells. BEP therapy and chemotherapy regimens administered for nongestational choriocarcinoma and gestational choriocarcinoma proved ineffective, and the patient died 21 months after diagnosis of metastatic choriocarcinoma. CONCLUSION: Metastaic nongestational pure choriocarcinoma of ovary is an extremely rare and an aggressive disease, frequently resulting in poor outcome.

    DOI： 10.1186/s13048-021-00810-3

    Web of Science

    PubMed

  213. Factors associated with neonatal mortality in a tertiary hospital in Phnom Penh, Cambodia Reviewed International coauthorship

    Leak P, Yamamoto E, Noy P, Keo D, Krang S, Kariya T, Saw YM, Siek M, Hamajima N.

    Nagoya Jouranl of Medical Science   Vol. 83 ( 1 ) page： 113 - 124   2021.2

    　More details

    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.18999/nagjms.83.1.113.

  214. Rate of achievement of therapeutic outcomes and factors associated with control of non-communicable diseases in rural east Malaysia: implications for policy and practice Reviewed International coauthorship

    Keng ZY, Saw YM, Thung SC, Chong WW, Albert A, Kariya T, Yamamoto E, Hamajima N.

    Scientific Reports   Vol. 11 ( 1 ) page： 3812 - 3812   2021.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-021-83168-2.

  215. Core 2 β1,6-N-acetylglucosaminyltransferases accelerate the escape of choriocarcinoma from natural killer cell immunity Reviewed

    Nakamura K, Niimi K, Yamamoto E, Ikeda Y, Nishino K, Suzuki S, Kajiyama H, Kikkawa F.

    Biochem Biophys Rep .   Vol. 26   page： 100951 - 100951   2021.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrep.2021.100951.

  216. Factors associated with neonatal mortality in a tertiary hospital in Phnom Penh, Cambodia.

    Ponloeu Leak, Eiko Yamamoto, Pisey Noy, Dane Keo, Sidonn Krang, Tetsuyoshi Kariya, Yu Mon Saw, Meng Siek, Nobuyuki Hamajima

    Nagoya journal of medical science   Vol. 83 ( 1 ) page： 113 - 124   2021.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    This study aimed to identify hospital neonatal mortality rate (NMR) and the causes of neonatal deaths, and to understand risk factors associated with neonatal mortality in a national tertiary hospital in Cambodia. The study included all newborn infants, aged 0-28 days old, hospitalized in the Pediatrics department of Khmer-Soviet Friendship Hospital between January 2016 and December 2017. In total, 925 infants were included in the study. The mean gestational age was 35.9 weeks (range, 24-42 weeks). Preterm infants and low birth weight accounted for 47.5% and 56.7%, respectively. With respect to payment methods, the government (53.5%) and non-governmental organizations (NGO) (13.7%) paid the fees as the families were not in a financial position to do so. The hospital NMR at the Pediatrics department was 9.3%. Respiratory distress syndrome (37.2%) was the main cause of deaths followed by hypoxic-ischemic encephalopathy (31.4%) and neonatal infection (21.0%). Factors associated with neonatal mortality were Apgar score at 5th minute <7 (adjusted odds ratio (AOR) = 3.57), payment by the government or NGO (AOR = 11.32), admission due to respiratory distress (AOR = 11.94), and hypothermia on admission (AOR = 9.41). The hospital NMR in the Pediatrics department was 9.3% (95% confidence interval 7.50-11.35) at Khmer-Soviet Friendship Hospital; prematurity and respiratory distress syndrome were the major causes of neonatal mortality. Introducing continuous positive airway pressure machine for respiratory distress syndrome and creating neonatal resuscitation guidelines and preventing hypothermia in delivery rooms are required to reduce the high NMR.

    DOI： 10.18999/nagjms.83.1.113

    Web of Science

    PubMed

  217. Assessment of quality of life among elderly in urban and peri-urban areas, Yangon Region, Myanmar. Reviewed International coauthorship International journal

    Poe Ei Zin, Yu Mon Saw, Thu Nandar Saw, Su Myat Cho, Su Su Hlaing, May Thet Nu Noe, Tetsuyoshi Kariya, Eiko Yamamoto, Kay Thi Lwin, Hla Hla Win, Nobuyuki Hamajima

    PloS one   Vol. 15 ( 10 ) page： e0241211   2020.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: In the context of an aging population, quality of life (QOL) is an important consideration for the well-being of the elderly. However, there is limited information on the QOL of the elderly in Myanmar. This study aimed to explore the risk factors for low QOL among the elderly in urban and peri-urban areas of the Yangon Region, Myanmar. METHODS: A community-based, cross-sectional study was conducted among the elderly aged 60 years or older in two urban and two peri-urban townships in the Yangon Region from July to September 2019. A multi-stage sampling method was used to recruit study participants using a pre-tested questionnaire. A total of 616 (305 males and 311 females) elderly people were interviewed using a face-to-face interview technique. Multiple linear regression analysis was performed on the four domains (physical health, psychological health, social relationship, and environment) of QOL measured with the WHOQOL-BREF. RESULTS: Income level and having intimate friends influenced the QOL scores of the elderly in all domains, while education level and marital status influenced psychological health, social relationship, and environment domains. Social interaction with neighbors increased the QOL scores for physical health, social relationship, and environment domains. Living in peri-urban areas was associated with lower QOL scores for physical health, psychological health, and environment, while participation in group activities increased QOL scores in these domains. Having comorbidities affected the QOL for psychological health and environment domains, while the frequency of going out affected physical health, and the frequency of religious performance affected social relationship. CONCLUSION: Residential location, education level, marital status, income, comorbidities, social interactions with neighbors and friends, participation in group activities, and frequencies of going out and religious activities should be considered in planning and implementing programs for the elderly in Myanmar. Peri-urban development, strengthening healthcare and social security systems, and encouraging social interaction and participation in group activities play critical roles in improving the QOL for elderly residing in Myanmar.

    DOI： 10.1371/journal.pone.0241211

    Web of Science

    PubMed

  218. Geographic distribution and utilisation of CT and MRI services at public hospitals in Myanmar. Reviewed International coauthorship International journal

    Moe Khaing, Yu Mon Saw, Thet Mon Than, Aye Myat Mon, Su Myat Cho, Thu Nandar Saw, Tetsuyoshi Kariya, Eiko Yamamoto, Nobuyuki Hamajima

    BMC health services research   Vol. 20 ( 1 ) page： 742 - 742   2020.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Diagnosis by computed tomography (CT) and magnetic resonance imaging (MRI) is important for patient care. However, the geographic distribution and utilisation of these machines in countries with limited resources, such as Myanmar, have not been sufficiently studied. Therefore, this study aims to identify the geographic distribution and utilisation of CT and MRI services at public hospitals in Myanmar. METHODS: This nationwide, cross-sectional study was conducted at 43 public hospitals in Myanmar. Data were collected retrospectively using a prepared form from 1st January 2015 to 31st December 2017 at public hospitals in Myanmar. A descriptive analysis was performed to calculate the number of CT and MRI units per million population in each state and region of Myanmar. The distribution of CT and MRI units was assessed using the Lorenz curve and Gini coefficient, which are indicators of inequality in distribution. RESULTS: In total, 45 CT and 14 MRI units had been installed in public hospitals in Myanmar by 2017. In total, 205,570 CT examinations and 18,981 MRI examinations have been performed within the study period. CT units per million population in 2017 varied from 0.30 in Rakhine State to 3.22 in Kayah State. However, MRI units were available only in public hospitals in five states/regions. The Gini coefficient for CT and MRI was 0.35 and 0.69, respectively. An upward trend in the utilisation rate of CT and MRI was also observed during the study period, especially among patients aged between 36 and 65 years. CONCLUSIONS: Throughout Myanmar, CT units were more equally distributed than MRI units. CT and MRI units were mostly concentrated in the Yangon and Mandalay Regions, where the population density is higher. The geographic distribution and utilisation rate of CT and MRI units varied among states, regions, and patients' age group. However, the utilisation rates of CT and MRI increased annually in all states and regions during the review period. The Ministry of Health and Sports in Myanmar should consider the utilisation and population coverage of CT and MRI as an important factor when there will be procurement of those medical equipment in the future.

    DOI： 10.1186/s12913-020-05610-x

    Web of Science

    PubMed

  219. Determinants of diarrhea in children under the age of five in Afghanistan: a secondary analysis of the Afghanistan Demographic and Health Survey 2015. Reviewed International coauthorship

    Ahmad Nasir Wasiq, Yu Mon Saw, Sultani Jawid, Tetsuyoshi Kariya, Eiko Yamamoto, Nobuyuki Hamajima

    Nagoya journal of medical science   Vol. 82 ( 3 ) page： 545 - 556   2020.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Diarrhea is the second leading cause of under-five mortality and globally accounts for 526,000 child deaths every year. Afghanistan, with 33,000 child deaths in 2012, was ranked 8th among nations, with the highest under-five deaths being from pneumonia and diarrhea. This study aimed to identify the determinants of diarrhea in children under the age of five in Afghanistan. A secondary data analysis of the Afghanistan Demographic and Health Survey (AfDHS) 2015 was focused on diarrhea in children under the age of five. The dataset of the AfDHS 2015 was used for the analysis. The subjects for this study were 30,238 under-five children. A logistic regression model was applied to examine the determinants of childhood diarrhea. This study found that 7,921 (26.2%) out of 30,238 under-five children had diarrhea within the two weeks preceding the survey. Higher maternal education accompanied a lower risk of childhood diarrhea with an adjusted odds ratio (AOR) of 0.70 (P<0.01) than did no education. Flush toilets (AOR=0.84, P<0.01) and traditional dry vaults (AOR=0.83, P<0.001) were less likely associated with diarrhea compared with pit latrines. Tube wells, public taps, and unprotected wells and springs were sources of drinking water with a higher risk of diarrhea than piped water. This study identified that the type of toilet facility, source of drinking water, age of the child, and maternal education were important determinants of under-five diarrhea. Intervention programs concerning improved sanitation facilities, sources of drinking water, and raising women's level of education and health awareness are important.

    DOI： 10.18999/nagjms.82.3.545

    Web of Science

    PubMed

  220. Estimation of the unvaccinated among those aged less than 25 years according to aimag and its association with incidence of measles outbreak 2015-2016 in Mongolia. Reviewed International coauthorship

    Enkhbold Sereenen, Yu Mon Saw, Ryenchindorj Erkhembayar, Baigal Volodya, Otgonbayar Dashpagma, Oyunchimeg Orsoo, Tetsuyoshi Kariya, Chimedsuren Ochir, Eiko Yamamoto, Nobuyuki Hamajima

    Nagoya journal of medical science   Vol. 82 ( 3 ) page： 437 - 447   2020.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Mongolia had an epidemic of measles in 2015-2016, even though more than 90% of the population have been vaccinated since 1997. This study aimed to examine the associations between unvaccinated proportion and measles incidence according to aimag. Mongolia has 21 provinces (aimag) with Ulaanbaatar as the capital city. Vaccination coverage between 1991 and 2014 and measles incidence according to aimag were obtained from the National Center for Communicable Diseases of Mongolia database. Accumulated unvaccinated proportion (AUP) among those aged 1 to 24 years in 2015 was estimated from the unvaccinated at the 1st dose of 1991 to 2014. From 1991 to 2014, unvaccinated proportion among those aged 1 to 24 years in the whole country has been reducing from 28.0% in 1991 to 1.8% in 2014. The AUP in 2015 varied from 2.7% (Selenge) to 21.8% (Govisumber). The incidence was remarkably higher in only two aimags with a large density of the unvaccinated aged 1 to 24 years (Ulaanbaatar and Darkhan-Uul) than in the other aimags. The incidence had no significant correlation with the AUP, although the correlation between the incidence and the density of unvaccinated aged 1 to 24 years was significant when the two aimags were included. In conclusion, the AUP between 2.7% and 21.8% had no correlation with the incidence according to aimags in Mongolia measles epidemic 2015-2016.

    DOI： 10.18999/nagjms.82.3.437

    Web of Science

    PubMed

  221. Etiologic agents of acute diarrhea in sentinel surveillance sites in Vientiane Capital, Lao People's Democratic Republic, 2012-2015. Reviewed International coauthorship International journal

    Souphatsone Houattongkham, Eiko Yamamoto, Noikaseumsy Sithivong, Souphalak Inthaphatha, Tetsuyoshi Kariya, Yu Mon Saw, Arounnapha Vongduangchanh, Onechanh Keosavanh, Nobuyuki Hamajima

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology   Vol. 39 ( 6 ) page： 1115 - 1122   2020.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    This study aims to identify the pathogens of diarrhea in Vientiane Capital, Lao People's Democratic Republic (Lao PDR). The data of 2482 patients who visited eight health facilities due to diarrhea in 2012-2015 were retrospectively reviewed. Stool or rectal swabs collected from all patients were tested for bacteria. Children who were under 5 years old were additionally tested for rotavirus. Of 2482 cases, 1566 cases were under 5 years old, and at least one enteropathogen was detected in 475 cases (19.1%). Salmonella species was the most commonly detected bacterial pathogen. Enteropathogenic Escherichia coli (EPEC) and Salmonella species was the major pathogen in the dry season and the wet season, respectively. Eighty-seven patients tested positive for multiple bacteria. Rotavirus was detected in 291 children under 5 years old (32.4%), mostly from October to April. The major bacteria of coinfection with rotavirus were EPEC followed by Salmonella species. Salmonella species was the predominant bacterial pathogen of diarrhea of all ages, and rotavirus was the predominant pathogen among children under 5 years old. Further studies examining other types of pathogens for diarrhea and the introduction of a rotavirus vaccine for children are needed in Lao PDR.

    DOI： 10.1007/s10096-020-03827-6

    Web of Science

    PubMed

  222. Evaluation of a routine second curettage for hydatidiform mole: a cohort study. Reviewed

    Eiko Yamamoto, Kimihiro Nishino, Kaoru Niimi, Eri Watanabe, Yukari Oda, Kazuhiko Ino, Fumitaka Kikkawa

    International journal of clinical oncology   Vol. 25 ( 6 ) page： 1178 - 1186   2020.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVE: The aim of this study was to evaluate routine second curettage for hydatidiform mole (HM) by comparing the characteristics and outcomes of developing gestational trophoblastic neoplasia (GTN). STUDY DESIGN: This was a cohort study including 173 patients diagnosed with HM between January 2002 and August 2019 who were followed up at Nagoya University Hospital, Japan. After an evacuation, 105 and 68 patients were managed with the routine method (routine group) and elective method (elective group) for a second curettage, respectively. The routine second curettage was performed around 7 days after the first evacuation. Patients in the elective group underwent a second curettage if there was ultrasonographic evidence of molar remnants in the uterine cavity. Socio-clinical factors were retrospectively compared between the routine and elective groups, and between patients showing regression and those who developed GTN. RESULTS: The incidence of GTN was 15.2% in the routine group and 20.6% in the elective group, and the difference was not significant (P = 0.364). The median GTN risk score was significantly higher in the routine group than in the elective group (P = 0.033). Presence of a complete HM, gestational age, and a pre-treatment human chorionic gonadotropin level of ≥ 200,000 mIU/mL were independent risk factors for GTN in molar patients. CONCLUSION: The incidence of GTN was unchanged but the risk score of GTN was higher in the routine group than in the elective group. Routine second curettage may not be necessary, but further study will be needed to confirm this.

    DOI： 10.1007/s10147-020-01640-x

    Web of Science

    PubMed

  223. Prevalence of alcohol consumption and its risk factors among university students: A cross-sectional study across six universities in Myanmar. Reviewed International coauthorship International journal

    Hein Htet, Yu Mon Saw, Thu Nandar Saw, Nang Mie Mie Htun, Khaing Lay Mon, Su Myat Cho, Thinzar Thike, Aye Thazin Khine, Tetsuyoshi Kariya, Eiko Yamamoto, Nobuyuki Hamajima

    PloS one   Vol. 15 ( 2 ) page： e0229329   2020.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Globally, alcohol consumption is a significant public health concern and it is one of the most important risk behaviours among university students. Alcohol consumption can lead to poor academic performance, injuries, fights, use of other substances, and risky sexual behaviours among students. However, the study explored the prevalence of alcohol consumption and the associated risk factors among university students since these have not been fully examined in previous research. Therefore, the aim of this study was to explore the prevalence of alcohol consumption and the associated risk factors among university students in Myanmar. METHODS: The present cross-sectional study was conducted using a sample of 15-24-year-old university students who were selected from six universities in Mandalay, Myanmar, in August 2018. In total, 3,456 students (males: 1,301 and females: 2,155) were recruited and asked to respond to a self-administered questionnaire. Multiple logistic regression analysis was used to estimate the adjusted odds ratio (AOR) and 95% confidence interval (CI) for alcohol consumption among university students. RESULTS: The prevalence of alcohol consumption in the previous 30 days was 20.3% (males: 36.0%, females: 10.8%). The alcohol consumption was significantly higher among males (AOR = 2.3, 95% CI; 1.9-2.9), truant students (AOR = 2.1, 95% CI; 1.3-3.3), smokers (AOR = 7.0, 95% CI; 5.1-9.7), students who reported feeling of hopelessness or sadness (AOR = 1.4, 95% CI; 1.2-1.8), peers' alcohol consumption (AOR = 7.5, 95% CI; 4.8-11.7). CONCLUSION: The present study revealed that males, smokers, peer alcohol consumption, and truant students had higher odds of alcohol consumption among the students. Therefore, effective campus-based counselling, peer education, and national surveillance systems that can monitor risky drinking behaviours among university students should be implemented. Further, government regulations that control the production, sale, promotion, advertising, and restriction of alcohol should be well developed and strengthened, as in the case of other Southeast Asian countries.

    DOI： 10.1371/journal.pone.0229329

    Web of Science

    PubMed

  224. Association between body mass index and ready-to-eat food consumption among sedentary staff in Nay Pyi Taw union territory, Myanmar. Reviewed International coauthorship International journal

    Thin Zar Thike, Yu Mon Saw, Htin Lin, Khin Chit, Aung Ba Tun, Hein Htet, Su Myat Cho, Aye Thazin Khine, Thu Nandar Saw, Tetsuyoshi Kariya, Eiko Yamamoto, Nobuyuki Hamajima

    BMC public health   Vol. 20 ( 1 ) page： 206 - 206   2020.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Ready-to-eat (RTE) food consumption has become popular in the working community with the increase in full-time jobs and the limited time to prepare food. Although RTE food is essential for this community, its consumption causes obesity. In Myanmar, obesity is a modifiable risk factor for non-communicable diseases, causing increases in morbidity and mortality. This study aimed to identify the association between body mass index (BMI) and RTE food consumption among sedentary staff in Nay Pyi Taw Union Territory, Myanmar. METHODS: A cross-sectional study was conducted in 2018, in which 400 respondents participated in face-to-face interviews. The study area was selected using simple random sampling and drawing method. Measuring tape and digital weighing scale were used to measure the height and weight of the respondents. BMI was calculated by dividing the weight by height squared (kg/m2). Overweight and obesity were categorized by World Health Organization cut-off points. The collected data were analyzed using multiple logistic regression to estimate the adjusted odds ratio (AOR), and the 95% confidence interval (CI). RESULTS: This study revealed that sedentary staff who consumed RTE food once or more per month were nearly five times more likely to be overweight and obese (AOR = 4.78, 95% CI 1.44-15.85) than those who consumed RTE food less frequently. In addition, five factors namely being older than 32 years (AOR = 3.97, 95% CI 1.82-8.69), preference for RTE food (AOR = 8.93, 95% CI 2.54-31.37), light-intensity of physical exercise (AOR = 3.55, 95% CI 1.63-7.73), sedentary leisure activities (AOR = 3.32, 95% CI 1.22-9.03), and smoking (AOR = 5.62, 95% CI 1.06-29.90) were positively associated with overweight and obesity. CONCLUSION: Frequent consumers of RTE food and less physically active sedentary staff were more likely to be overweight and obese. This study highlights the urgent need to raise awareness regarding healthy lifestyle behaviors among the working community to reduce the burden of obesity-related chronic diseases. Moreover, sedentary workers should be aware of the food-based dietary guidelines of the country. Policy makers should strictly enforce nutritional labeling of RTE food, and strictly prohibit over-branding of RTE food.

    DOI： 10.1186/s12889-020-8308-6

    Web of Science

    PubMed

  225. Cross-sectional study on tobacco advertising, promotion and sponsorship (TAPS) and violations of tobacco sale regulations in Myanmar: do these factors affect current tobacco use among Myanmar high school students? Reviewed International coauthorship International journal

    Su Myat Cho, Yu Mon Saw, Nyi Nyi Latt, Thu Nandar Saw, Hein Htet, Moe Khaing, Thet Mon Than, Ei Mon Win, Zaw Zaw Aung, Tetsuyoshi Kariya, Eiko Yamamoto, Nobuyuki Hamajima

    BMJ open   Vol. 10 ( 2 ) page： e031933   2020.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVES: To examine the associations of current tobacco use with tobacco advertising, promotion and sponsorship (TAPS), and illicit tobacco sales exposures among Myanmar high school students. DESIGN: A quantitative, cross-sectional study. SETTING: Seven high schools from both urban and rural areas of four states and regions in Myanmar. PARTICIPANTS: In total, 1174 high school students (482 males and 692 females) were interviewed using a self-administered questionnaire. MAIN OUTCOME MEASURE: Current tobacco use of participants, defined as using any kind of smoked or smokeless tobacco product at least one occasion within the past 30 days. RESULTS: The prevalence of TAPS exposure was 90.9% among high school students in Myanmar. Current tobacco use was positively associated with being over 14 years old (adjusted OR (AOR) 9.81; 95% CI 4.54 to 21.19), being male (AOR 28.06; 95% CI 13.29 to 59.25), exposure to any kind of TAPS (AOR 6.59; 95% CI 2.33 to 18.64), having seen any smoked tobacco product for sale inside or within 100 feet of the school premises (AOR 4.17; 95% CI 1.65 to 10.58), having seen the sale or gifting of any smoked tobacco product to minors (AOR 6.46; 95% CI 2.18 to 19.12) and having seen the sale or distribution of any smoked tobacco product by minors (AOR 2.42; 95% CI 1.42 to 4.10). Having ever received health education about tobacco use (AOR 0.45; 95% CI 0.27 to 0.78), or having a higher perception score of tobacco use (AOR 0.17; 95% CI 0.10 to 0.30) were negatively associated with current tobacco use. CONCLUSIONS: There was an alarming prevalence of TAPS exposure among Myanmar high school students. TAPS exposure and violations of tobacco sale regulations were strong risk factors for current tobacco use among Myanmar high school students, while health education about tobacco products was reported as an effective protective factor. Specific smokeless tobacco sale regulations for minors are needed immediately in Myanmar.

    DOI： 10.1136/bmjopen-2019-031933

    Web of Science

    PubMed

  226. Estimating cost of hospitalization for childbirth at a tertiary hospital in Mongolia. Reviewed International coauthorship

    Bolorchimeg Taazan, Eiko Yamamoto, Bayart Baatar, Avirmed Amgalanbaatar, Tetsuyoshi Kariya, Yu Mon Saw, Nobuyuki Hamajima

    Nagoya journal of medical science   Vol. 82 ( 1 ) page： 47 - 57   2020.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Health services for pregnancy and delivery at public health facilities are fully subsidized by the government in Mongolia. However, it has been reported that health financing, budget planning, and implementation processes are weak. Therefore, this study aims to estimate the costs per inpatient of vaginal delivery and cesarean section (C-section) by using data gathered from a tertiary hospital in Ulaanbaatar. Inpatient and financial data were collected from the Statistics and Finance, Economics Department of National Center for Maternal and Child Health. A top-down method was used for the calculation of unit costs. The total number of deliveries in 2016 were 11,033, including 7,777 vaginal deliveries and 3,256 C-sections. The cost per inpatient stay for vaginal delivery and C-section were USD 255 and USD 592, respectively. The average cost per bed-day of the six departments of the obstetrics and gynecology hospital was USD 80. The percentage that represents employees' salary in the cost per inpatient was as low as 12.4% for vaginal delivery and 18.5% for C-section, although the cost for salaries accounted for 51.2% of the total expenditure of the hospital. Results show that the cost per inpatient of C-section was two times higher than that of vaginal delivery. The cost of childbirths may account for approximately 9% of total health expenditure of the country. These results may be advantageous to the government in instituting a policy and controlling the health care budget to improve cost-effectiveness and equal access to all in health care services in Mongolia.

    DOI： 10.18999/nagjms.82.1.47

    Web of Science

    PubMed

  227. Disease frequency among inpatients at a tertiary general hospital in Lao PDR. Reviewed International coauthorship

    Viengsakhone Louangpradith, Bounfeng Phoummalaysith, Tetsuyoshi Kariya, Yu Mon Saw, Eiko Yamamoto, Nobuyuki Hamajima

    Nagoya journal of medical science   Vol. 82 ( 1 ) page： 113 - 121   2020.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    In Lao People's Democratic Republic (Lao PDR), reports on disease frequency are very limited. This study aimed to report frequencies of the main cause of admission among inpatients of a tertiary general hospital (Mittaphab Hospital) in Vientiane. Subjects were inpatients who were admitted from January 3 to February 2 in 2017. The dataset were made as a pilot run to establish hospital statistics. The data on sex, age, address (province), dates of admission and discharge, and main diagnosis were collected from paper-based medical charts. International Classification of Diseases 10 was applied for classifying the main diagnosis. During the 1-month period, 1,201 inpatients (637 males and 564 females) were admitted, including 171 (14.2%) aged <20 years and 254 (21.1%) aged ≥60 years. About 20% patients were from outside of Vientiane. Among them, 67.5% (62.5% in males and 73.8% in females) were admitted within 7 days. The main causes with more than 10% in males were injury and poisoning S00-T98 (49.8%), while those in females were injury and poisoning S00-T98 (25.2%), pregnancy and childbirth O00-O99 (19.0%), and diseases of genitourinary system N00-N99 (13.7%). Injury and poisoning S00-T98 among inpatients aged <20 years was 81.8% in males and 59.0% in females. Among those aged 20-59 years, it was 49.9% and 22.4%, and among those aged ≥60 years it was 22.3% and 16.9%, respectively. This is the first report on the frequencies of main diseases among inpatients in Lao PDR. Injury was the first main cause of admission at the tertiary hospital.

    DOI： 10.18999/nagjms.82.1.113

    Web of Science

    PubMed

  228. Assessing risk factors and impact of cyberbullying victimization among university students in Myanmar: A cross-sectional study. Reviewed International coauthorship International journal

    Aye Thazin Khine, Yu Mon Saw, Zaw Ye Htut, Cho Thet Khaing, Htin Zaw Soe, Kyu Kyu Swe, Thinzar Thike, Hein Htet, Thu Nandar Saw, Su Myat Cho, Tetsuyoshi Kariya, Eiko Yamamoto, Nobuyuki Hamajima

    PloS one   Vol. 15 ( 1 ) page： e0227051   2020.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND: Cyberbullying is a global public health concern with tremendous negative impacts, not only on the physical and mental health of students but also on their well-being and academic performance. However, there are very few studies on cyberbullying among university students, especially in Myanmar. This study aims to determine the percentage of university students who suffered cyberbullying victimization in the last 12 months, and the association between students' socio-demographic characteristics, adverse events following cyberbullying and cyberbullying victimization. METHODS: A cross-sectional study was conducted among university students aged 18 years and older at one medical university in Magway, Myanmar. A total of 412 students (277 males and 135 females) participated in the study. Data were collected from August to September, 2018 using a self-administered questionnaire. Multiple logistic regression analyses (models I and II) were performed to estimate the unadjusted (UOR) and adjusted odds ratios (AOR), and 95% confidence intervals (CI). RESULTS: In total, 40.8% of males and 51.1% of females in the study had suffered cyberbullying victimization in the past 12 months. In model I, students who had been studying at the university for 3 years or less (AOR = 1.81; 95% CI 1.14-2.85), and who had witnessed psychological, physical or sexual violence, or cyberbullying in their neighborhoods, (AOR = 2.95; 95% CI 1.48-5.91) were more likely to have suffered cyberbullying victimization in the past 12 months. In model II, being a victim of cyberbullying was associated with difficulties in concentrating and understanding lectures (AOR = 3.96; 95% CI 1.72-9.11), and substance abuse (AOR = 2.37; 95% CI 1.02-5.49). Non-resident students were at a higher risk of being cyberbullying victims than their resident peers (AOR = 1.86; 95% CI 1.04-3.34). CONCLUSION: Two out of five students had suffered cyberbullying victimization in the past 12 months, and only half of the victims discussed their experience(s) with someone else. Students who suffered cyberbullying victimization faced academic difficulties and started or increased smoking, betel chewing or alcohol drinking. Counter measures to prevent and mitigate the adverse events related to cyberbullying victimization are urgently needed among university students in Myanmar. Periodic screening for cyberbullying, counseling services, cyber-safety educational programs, and awareness raising campaigns should be implemented.

    DOI： 10.1371/journal.pone.0227051

    Web of Science

    PubMed

  229. Assessment of nutritional status and risk factors for malnutrition among the elderly in Loikaw, Myanmar Reviewed International coauthorship

    May Thet Nu Noe, Yu Mon Saw, Thu Nandar Saw, Yoon Pwint Kyaw, Poe Ei Zin, Su Myat Cho, Tetsuyoshi Kariya, Eiko Yamamoto, Hla Hla Win, Tin Wann, Nobuyuki Hamajima

    Nutrition   Vol. 79-80   page： 110933 - 110933   2020

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.nut.2020.110933

    Web of Science

    PubMed

  230. Dengue fever during pregnancy

    Trinh Tien Dat, Kotani Tomomi, Yamamoto Eiko, Shibata Kiyosumi, Moriyama Yoshinori, Tsuda Hiroyuki, Yamashita Mamoru, Kajiyama Hiroaki, Dien Duc Thien Minh, Le Quang Thanh, Kikkawa Fumitaka

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 2 ) page： 241 - 247   2018.5

    　More details

  231. Establishment and characterization of cell lines derived from complete hydatidiform mole. Reviewed

    Yamamoto E, Niimi K, Kiyono T, Yamamoto T, Nishino K, Nakamura K, Kotani T, Kajiyama H, Shibata K, Kikkawa F

    International Journal of Molecular Medicine   Vol. 40 ( 3 ) page： 614-622   2017.9

    　More details

    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    Gestational trophoblastic diseases (GTDs) are a group of diseases characterized by abnormal cellular proliferation of atypical trophoblasts. A hydatidiform mole is an abnormal pregnancy caused by genetic fertilization disorders, and it can be classified as a complete hydatidiform mole (CHM) or a partial hydatidiform mole. The aim of this study was to establish cell lines from CHMs and to characterize the cells for future studies concerning GTD. HMol1-2C, HMol1-3B, HMol1-8 and HMol3-1B were established from primary cultures of CHM explants following the introduction of different combinations of genes including human telomerase reverse transcriptase (hTERT), a mutant form of CDK (CDK4R24C), cyclin D1, p53C234, MYC and HRAS. HMol1-2C, HMol1-3B, and HMol3-1B were confirmed to originate from trophoblasts of androgenic, homozygous CHMs. These three cell lines exhibited low human chorionic gonadotropin secretion, low migration and invasion abilities, and the potential to differentiate into syncytiotrophoblastic cells via forskolin treatment. These results suggest that these cells exhibit characteristics of trophoblastic cells, especially cytotrophoblastic cells. HMol1-8 was found to consist of diploid cells and originated from maternal cells, suggesting that they were derived from decidual cells. In conclusion, we successfully established three cell lines from CHMs by introduction of hTERT and other genes. Analysis revealed that the genetic origin of each cell line was identical with that of the original molar tissue, and the cell lines exhibited characteristics of trophoblastic cells, which are similar to undifferentiated cytotrophoblasts.

    DOI： 10.3892/ijmm.2017.3067.

  232. Inhibition of ZEB1 leads to inversion of metastatic characteristics and restoration of paclitaxel sensitivity of chronic chemoresistant ovarian carcinoma cells. Reviewed

    Sakata J, Utsumi F, Suzuki S, Niimi K, Yamamoto E, Shibata K, Senga T, Kikkawa F, Kajiyama H.

    Oncotarget   Vol. 8 ( 59 ) page： 99482-99494   2017.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.18632/oncotarget.20107.

  233. N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma. Reviewed

    Nishino K, Yamamoto E, Niimi K, Sekiya Y, Yamashita Y, Kikkawa F.

    Oncology reports   Vol. 38 ( 1 ) page： 440-448   2017.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3892/or.2017.5661.

  234. Spontaneous regression of gestational trophoblastic neoplasia. Reviewed

    Niimi K, Yamamoto E, Nishino K, Fujiwara S, Ino K, Kikkawa F.

    Gynecolgic Oncology Reports   Vol. 25 ( 21 ) page： 98-100   2017.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.gore.2017.07.011.

  235. c-Rel Promotes Invasion of Choriocarcinoma Cells via PI3K/AKT Signaling. Reviewed

    Sekiya Y, Yamamoto E, Niimi K, Nishino K, Nakamura K, Kotani T, Kajiyama H, Shibata K, Kikkawa F.

    Oncology   Vol. 92 ( 5 ) page： 299-310   2017.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVE:
    Choriocarcinoma is the most common epithelial cancer among gestational trophoblastic diseases (GTDs); the mechanism of trophoblastic carcinogenesis is unknown. This study aimed to examine the expression of NF-κB family proteins in GTDs and placental tissues as well as the roles of c-Rel in choriocarcinoma.
    METHODS:
    We examined the expression of NF-κB family proteins in normal placenta and hydatidiform mole tissues as well as extravillous trophoblast (EVT) and choriocarcinoma cell lines by Western blot and immunohistochemistry. Immunoprecipitation was performed to determine which proteins can bind with c-Rel in choriocarcinoma cells. To investigate the roles of c-Rel in choriocarcinoma, we examined the effects of c-Rel knockdown and overexpression on cell proliferation, migration, and invasion using small interfering RNAs and gene activation plasmid.
    RESULTS:
    The expression of c-Rel was strong in choriocarcinoma and EVTs, but very weak in villi of normal placenta and hydatidiform mole. Immunoprecipitation suggested that c-Rel heterodimerizes with p65 in choriocarcinoma. c-Rel knockdown reduced invasion, migration, and AKT phosphorylation in choriocarcinoma cells. c-Rel overexpression in choriocarcinoma increased migratory and invasive abilities, and the effect on invasion was inhibited by a PI3K inhibitor.
    CONCLUSION:
    These findings suggest that c-Rel might play a role in promoting the invasion of choriocarcinoma cells through PI3K/AKT signaling.

    DOI： 10.1159/000458529.

  236. High-dose chemotherapy with autologous peripheral blood stem cell transplantation for choriocarcinoma: A case report and literature review. Reviewed

    Yamamoto E, Niimi K, Fujikake K, Nishida T, Murata M, Mitsuma A, Ando Y, Kikkawa F.

    Molecular and Clinical Oncology   Vol. 5 ( 5 ) page： 660-664   2016.11

    　More details

    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    Choriocarcinoma is a malignant gestational trophoblastic neoplasia (GTN) and one of the curable types of gynecological cancer. However, 10% of choriocarcinoma patients have a poor prognosis, particularly when they have metastasis, apart from pulmonary metastasis, or do not go into remission by the second chemotherapeutic regimen. We herein present the case of a 36-year-old patient who had choriocarcinoma with metastases to the lungs, liver and kidneys. The 5th and 6th regimens with cisplatin for choriocarcinoma failed and the patient developed brain metastases. She was then treated with four cycles of high-dose ifosfamide, carboplatin and etoposide (ICE) with blood progenitor cell support after confirming the effectiveness of ICE at normal doses. The serum human chorionic gonadotropin (hCG) level was 140,009 mIU/ml at the start of high-dose ICE and the patient tolerated this regimen well. However, the beneficial effect was decreasing with each successive course of treatment, with the lowest level of hCG at 103 mIU/ml after the fourth course. The patient did not achieve complete remission and succumbed to the disease 4 months after the last chemotherapy. The findings of the present case and a review of the related literature suggest that high-dose ICE with stem cell rescue may be considered as a viable treatment option for a multi-drug resistant choriocarcinoma or GTN.

  237. Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model. Reviewed

    Ushida T, Kotani T, Tsuda H, Imai K, Nakano T, Hirako S, Ito Y, Li H, Mano Y, Wang J, Miki R, Yamamoto E, Iwase A, Bando YK, Hirayama M, Ohno K, Toyokuni S, Kikkawa F.

    Free Radic Biol Med.   Vol. 101   page： 524-533   2016.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.freeradbiomed.2016.10.491.

  238. Gestational Trophoblastic Neoplasia and Pregnancy Outcome After Routine Second Curettage for Hydatidiform Mole: A Retrospective Observational Study Reviewed

    Momo Kan, M.D., Eiko Yamamoto, M.D., Ph.D., Kaoru Niimi, M.D., Ph.D., Koji Tamakoshi, M.D., Ph.D., Yoko Sekiya, M.D., Kimihiro Nishino, M.D., Kazuhiko Ino, M.D., Ph.D., and Fumitaka Kikkawa, M.D., Ph.D.

    Journal of Reproductive Medicine   Vol. 61 ( 4 ) page： 373-379   2016.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    OBJECTIVE: To investigate gestational trophoblastic neoplasia (GTN), fertility, and pregnancy outcome in molar patients who underwent routine second curettage.
    STUDY DESIGN: Eighty-two patients who visited our hospital for hydatidiform mole between 2002 and 2011 were registered in this study. All patients had second curettage around the 7th day after first evacuation. We performed retrospective analysis on several factors between a remission group and a GTN group.

    RESULTS: Fourteen patients (17.1%) had chemotherapy after being diagnosed with GTN. Multivariate analysis revealed that the hCG value before first evacuation was only one independent prognostic factor for GTN. The median follow-up period was 45.5 months, and 41 patients had 62 pregnancies after remission of hydatidiform mole and GTN. The fertility rate was 80% in 45 patients with desire for a baby, and 39 pregnancies (62.9%) ended in live births without congenital malformation.

    CONCLUSION: The incidence of GTN was not lower in hydatidiform mole with routine second curettage. An independent prognostic factor for GTN was the hCG value before the first evacuation in molar patients. Our results suggest that routine second curettage does not affect the fertility rate or increase a risk of adverse outcomes in subsequent pregnancies.

  239. Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation Reviewed

    Shinjo K, Yamashita Y, Yamamoto E, Akatsuka S, Uno N, Kamiya A, Niimi K, Sakaguchi Y, Nagasaka T, Takahashi T, Shibata K, Kajiyama H, Kikkawa F, Toyokuni S.

    Int J Cancer   Vol. 135 ( 2 ) page： 305   2014.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

  240. Suppression of REV7 enhances cisplatin sensitivity in ovarian clear cell carcinoma cells. Reviewed

    Niimi K, Murakumo Y, Watanabe N, Kato T, Mii S, Enomoto A, Asai M, Asai N, Yamamoto E, Kajiyama H, Shibata K, Kikkawa F, Takahashi M.

    Cancer Sci.   Vol. 105 ( 5 ) page： 545-52   2014.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

  241. Identification of causative pregnancy of gestational trophoblastic neoplasia diagnosed during pregnancy by short tandem repeat analysis. Reviewed

    Yamamoto E, Niimi K, Shinjo K, Yamamoto T, Fukunaga M, Kikkawa F.

    Gynecol Oncol Case Rep.   Vol. 9   page： 3-6   2014.4

    　More details

    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  242. High expression of N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma Reviewed

    Niimi K, Yamamoto E, Fujiwara S, Shinjo K, Kotani T, Umezu T, Kajiyama H, Shibata K, Ino K, Kikkawa F

    Br J Cancer   Vol. 107 ( 12 ) page： 1969-1977   2012.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

  243. 無心体の一例 Reviewed

    山本 英子, 石川 智則, 渡辺 真夕, 蛭川 純子, 湯原 均, 阿部 史朗, 猪俣 吉廣, 宇野 雅哉, 稲坂 織恵, 宮坂 尚幸

    日本産科婦人科学会関東連合地方部会会報   ( 3 ) page： 347   2000.8

    　More details

    Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)  

▼display all

To the head of Papers.▲

Books 28

  1. やさしくわかる産科婦人科検査マスターブック（大須賀譲、高松潔、田中守、渡部洋編集）．

    山本英子、新美薫、西野公博．（ Role： Contributor ,  絨毛性疾患のhCG．）

    診断と治療社  2020 

    　More details

    Language：Japanese

  2. 今日の治療指針（福井次矢、高木誠、小室一成総編集）．

    山本英子（ Role： Contributor ,  絨毛性疾患．）

    医学書院  2020 

    　More details

    Language：Japanese

  3. 産婦人科処方のすべて2020（大道正英、亀井良政、久慈直昭編集）．

    新美薫、山本英子、梶山広明．（ Role： Contributor ,  絨毛性疾患．）

    医学書院  2020 

    　More details

    Language：Japanese

  4. 産科婦人科疾患最新の治療2019-2021（吉川史隆、平松裕司、大須賀譲編集）．

    新美薫、山本英子．（ Role： Contributor ,  絨毛性疾患．）

    南江堂  2019 

    　More details

    Language：Japanese

  5. 現代の母性看護（入山茂美、春名めぐみ、大林陽子編）．

    （ Role： Contributor）

    名古屋大学出版会  2019 

    　More details

    Language：Japanese

  6. 基礎と臨床の両側面からみた胎盤学（日本胎盤学会編集）．

    山本英子．（ Role： Contributor ,  絨毛性疾患の臨床的分類、診断、治療、最近のトピックス．）

    メディカルレビュー社  2019 

    　More details

    Language：English

  7. 婦人科がん（第2版）‐最新の研究動向‐.

    山本英子、新美薫、西野公博．（ Role： Contributor ,  絨毛性疾患の疫学．）

    日本臨牀社  2018 

    　More details

    Language：Japanese

  8. 婦人科がん（第2版）‐最新の研究動向‐.

    新美薫、山本英子、梶山広明．（ Role： Contributor ,  中間型トロホブラスト腫瘍．）

    日本臨牀社  2018 

    　More details

    Language：Japanese

  9. 子宮体がん治療ガイドライン2018年版（日本婦人科腫瘍学会編）．

    （ Role： Contributor）

    金原出版  2018 

    　More details

    Language：Japanese

  10. 1336専門家による私の治療2017-2018年度版（監修　猿田享男、北村惣一郎）．

    新美薫、山本英子、吉川史隆．（ Role： Contributor ,  絨毛性腫瘍．）

    日本医事新報社  2017 

    　More details

    Language：Japanese

  11. 今日の治療指針（山口徹、北原光夫監修）．

    山本英子（ Role： Contributor ,  絨毛性疾患．）

    医学書院  2016 

    　More details

    Language：Japanese

  12. 産科婦人科疾患最新の治療2016-2018（吉川史隆、倉智博久、平松裕司編集）．

    新美薫、山本英子．（ Role： Contributor ,  絨毛性疾患．）

    南江堂  2016 

    　More details

    Language：Japanese

  13. 患者さんとご家族のための子宮頸がん子宮体がん卵巣がん治療ガイドライン（日本婦人科腫瘍学会編）．

    （ Role： Contributor）

    金原出版  2016 

    　More details

    Language：Japanese

  14. 絨毛性疾患に対する妊孕性温存治療

    井箟 一彦, 馬淵 泰士, 山本 英子（ Role： Joint author）

    医学書院  2015.9 

    　More details

    Language：Japanese

  15. 外来化学療法室 がん薬物療法カンファレンス（安藤雄一編)．

    山本英子（ Role： Contributor ,  化学療法による妊孕性への影響．）

    南山堂  2015 

    　More details

    Language：Japanese

  16. 婦人科癌診療Q&A（鈴木直、岡本愛光、井箟一彦編)．

    山本英子、三輪陽子、新美薫（ Role： Contributor ,  侵入奇胎、絨毛癌の化学療法後の生殖機能、妊娠、分娩に与える影響について教えてください．）

    中外医学者  2014 

    　More details

    Language：Japanese

  17. 絨毛性腫瘍の治療・予後に関する絨毛癌診断スコアとFIGO 2000 systemの比較検討

    山本 英子, 藤原 多子, 菅 もも, 新美 薫, 新城 加奈子, 吉川 史隆（ Role： Joint author）

    金原出版  2013.1 

    　More details

    Language：Japanese

  18. 子宮体がん治療ガイドライン2013年版（日本婦人科腫瘍学会編）．

    （ Role： Contributor）

    金原出版  2013 

    　More details

    Language：Japanese

  19. 山本 英子(名古屋大学 大学院医学系研究科発育・加齢医学(産婦人科学)), 藤原 多子, 菅 もも, 新美 薫, 新城 加奈子, 吉川 史隆

    山本英子，藤原多子，吉川史隆（ Role： Joint author）

    医学書院  2012.7 

    　More details

    Language：Japanese

  20. 絨毛癌の診断と治療

    山本英子，藤原多子，吉川史隆（ Role： Joint author）

    日本臨床  2012.6 

    　More details

    Language：Japanese

  21. 婦人科がん‐最新の研究動向‐.

    山本英子、藤原多子、吉川史隆．（ Role： Contributor ,  絨毛癌の診断と治療．）

    日本臨牀社  2012 

    　More details

    Language：Japanese

  22. 臨床婦人科産科　絨毛性疾患の病態・病因論 PSTT・存続絨毛症

    山本英子、吉川史隆（ Role： Joint author）

    医学書院  2011.3 

    　More details

    Language：Japanese

  23. 産婦人科の実際・絨毛性疾患化学療法後の妊娠転帰

    山本英子、藤原多子、吉川史隆（ Role： Joint author）

    金原出版  2011.2 

    　More details

    Language：Japanese

  24. 絨毛性疾患取り扱い規約第3版（日本産科婦人科学会・日本病理学会編）．

    （ Role： Contributor）

    金原出版  2011 

    　More details

    Language：Japanese

  25. がん診療のサポーティブケアガイド　「女性生殖器系の異常」

    山本英子（ Role： Sole author）

    文光堂  2010.3 

    　More details

    Language：Japanese

  26. 産科と婦人科 高齢妊娠の諸問題　「胞状奇胎」

    山本英子,　井箟一彦, 吉川史隆（ Role： Joint author）

    診断と治療社  2010.2 

    　More details

    Language：Japanese

  27. がん診療のサポーティブケアガイド（安藤雄一編)．

    （ Role： Contributor ,  女性生殖器系の異常．）

    文光堂  2010 

    　More details

    Language：Japanese

  28. 婦人科癌化学療法ポケットマニュアル

    山本英子、井箟一彦、吉川史隆．（ Role： Contributor ,  絨毛性腫瘍の化学療法．）

    メディカルレビュー社  2009 

    　More details

    Language：Japanese

▼display all

To the head of Books.▲

MISC 1

  1. 孤発性肺転移病巣の再燃を繰り返す妊娠性絨毛癌に対して,手術が有効であった1例

    西子 裕規, 新美 薫, 柴田 真由, 市川 義一, 小田 結加里, 渡邉 絵里, 西野 公博, 山本 英子, 梶山 広明

    日本婦人科腫瘍学会学術講演会プログラム・抄録集   Vol. 64回   page： 289 - 289   2022.7

    　More details

    Language：Japanese   Publisher：(公社)日本婦人科腫瘍学会  

To the head of MISC.▲

Presentations 40

  1. Proposal for guideline for management of gestational trophoblastic disease in Cambodia Invited International conference

    Eiko Yamamoto

    Society of Cambodian Gynecology Oncology 18th Annual Conference  2019.11.23  Society of Cambodian Gynecology Oncology

    　More details

    Event date： 2019.11

    Language：English   Presentation type：Oral presentation (invited, special)  

    Venue：Phnom Penh   Country：Cambodia  

  2. Clinical management of trophoblastic diseases Invited International conference

    Eiko Yamamoto

    Society of Cambodian Gynecology Oncology 16th Annual Conference  2017.11.27  Society of Cambodian Gynecology Oncology

    　More details

    Event date： 2017.11

    Language：English   Presentation type：Oral presentation (invited, special)  

    Venue：Phnom Penh   Country：Cambodia  

  3. Expression of N-acetylglucosaminyltransferase IVa in extravillous trophoblast and gestational trophoblastic disease International conference

    International Federation of Placenta Association 2009 

    　More details

    Event date： 2009.10

    Language：English   Presentation type：Poster presentation  

    Objectives: Hyperglycosylated hCG (hCG-H) is a glycoprotein variant of the hormone hCG and reported to be detected in serum and urine of early pregnant women, invasive mole and choriocarcinoma, but not of molar patients. N-acetylglucosaminyltransferase IVa (GnT-IVa) is one of glycosyltransferases to attach abnormal biantennary N-linked sugar chains to hCG. Our aim is to clarify the expression of GnT-IVa in gestational trophoblastic disease and extravillous trophoblasts (EVTs) in human placenta.

  4. English education and programs for studying abroad of Nagoya University Graduate School of Medicine International conference

    INTERNATIONAL CONFERENCE ON ‘ADVANCES IN EDUCATION, TEACHING AND LEARNING’  2021.12.3  Mongolian National University of Medical Sciences

    　More details

    Event date： 2021.12

    Language：English   Presentation type：Oral presentation (invited, special)  

    Venue：Ulaanbaatar (Hybrid)   Country：Mongolia  

  5. 日本の絨毛性疾患の特徴と発生率の推移：絨毛性疾患地域登録データ解析より

    山本英子

    第39回絨毛性疾患研究会  2021.11.26  東京薬科大学

    　More details

    Event date： 2021.11

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：東京   Country：Japan  

  6. 日本における絨毛性疾患の発生率推移と診断時臨床情報の解析 International coauthorship

    山本英子

    第73回日本産科婦人科学会学術講演会  2021.4.22  日本産科婦人科学会

    　More details

    Event date： 2021.4

    Language：Japanese   Presentation type：Poster presentation  

    Venue：新潟   Country：Japan  

  7. 絨毛性疾患地域登録データ解析にもとづいた絨毛性疾患患者の背景と発生率の推移 Invited

    山本英子、新美薫、西野公博、井箟一彦

    第38回日本絨毛性疾患研究会  2020.10.30 

    　More details

    Event date： 2020.10

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

    Venue：東京   Country：Japan  

  8. 胞状奇胎の掻爬回数と続発症頻度に関する全国調査 Invited

    兼城英輔、碓井宏和、山本英子、田代浩徳、矢幡秀昭、加藤聖子、宮本新吾、井箟一彦、八重樫伸生、榎本隆之

    第37回日本絨毛性疾患研究会  2019.11.29  日本絨毛性疾患研究会

    　More details

    Event date： 2019.11

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

    Venue：倉敷   Country：Japan  

  9. 絨毛性疾患の診断・治療

    山本英子

    第60回日本婦人科腫瘍学会学術講演会  2018.9.16  日本婦人科腫瘍学会（京都大学）

    　More details

    Event date： 2018.9

    Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    Venue：京都   Country：Japan  

  10. 絨毛性疾患の画像評価 Invited

    山本英子

    第35回日本絨毛性疾患研究会  2017.11.24  日本絨毛性疾患研究会

    　More details

    Event date： 2017.11

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

    Venue：長崎   Country：Japan  

  11. 複数レジメによる化学療法を行った難治性絨毛癌 Invited

    山本英子

    第34回日本絨毛性疾患研究会  2016.11.25  日本絨毛性疾患研究会

    　More details

    Event date： 2016.11

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

    Venue：和歌山   Country：Japan  

  12. ベトナムTuDu病院における胞状奇胎後続発症のリスク因子 Invited

    山本英子、Trinh DT, LE QT

    日本リスク研究学会第28回年次大会  2015.11.21 

    　More details

    Event date： 2015.11

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

    Venue：名古屋   Country：Japan  

  13. 自己末梢血幹細胞移植併用化学療法を試みた難治性多発絨毛癌

    第33回日本絨毛性疾患研究会

    山本英子、藤掛佳代、新美薫、三輪陽子、西野公博、吉川史隆 

    　More details

    Event date： 2015.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  14. 難治性絨毛癌に対する自己末梢血幹細胞移植併用化学療法の試み

    山本英子、藤掛佳代、新美薫、三輪陽子、西野公博、吉川史隆

    第67回日本産科婦人科学会学術講演会 

    　More details

    Event date： 2015.4

    Language：Japanese   Presentation type：Poster presentation  

    Venue：パシフィコ横浜   Country：Japan  

  15. PSTTの最新情報

    山本英子

    第32回日本絨毛性疾患研究会  2014.10.3  日本絨毛性疾患研究会

    　More details

    Event date： 2014.10

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

    Country：Japan  

  16. 糖鎖生物学を用いた絨毛細胞の悪性化機構と機能変化の解明

    山本英子

    第56回婦人科腫瘍学会学術集会  2014.7.7 

    　More details

    Event date： 2014.7

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  17. 絨毛性腫瘍に対する化学療法施行中の問題と対策

    山本英子

    第31回日本絨毛性疾患研究会  2013.10.25  日本絨毛性疾患研究会

    　More details

    Event date： 2013.10

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

    Country：Japan  

  18. 絨毛性疾患地域登録の書式改訂について

    山本英子

    第29回日本絨毛性疾患研究会 

    　More details

    Event date： 2011.9

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

    Venue：東京   Country：Japan  

  19. ESTABLISHMENT OF IMMORTALIZED HUMAN COMPLETE HYDATIDIFORM MOLE CELL LINES International conference

    Eiko Yamamoto, Kaoru Niimi, Kanako Shinjo, Sawako Fujiwara, Yukio Mano, Tomomi Kotani and Fumitaka Kikkawa.

    IFPA 2011 

    　More details

    Event date： 2011.9

    Language：English   Presentation type：Poster presentation  

    Country：Japan  

  20. 全胞状奇胎不死化細胞株の樹立

    山本英子　新城加奈子　新美薫　近藤紳司　東真規子　炭竈誠二　小谷友美　井箟　一彦　吉川史隆

    日本産科婦人科学会学術講演会 

    　More details

    Event date： 2011.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  21. 妊娠に合併した胎盤部トロホブラスト腫瘍

    山本　英子、藤原　多子、新城　加奈子、近藤　紳司、東　真規子、新美　薫、水野　昌彦、加藤　省一、福永　真治、吉川　史隆

    第50回婦人科腫瘍学会学術集会 

    　More details

    Event date： 2011.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：札幌   Country：Japan  

  22. 全胞状奇胎不死化細胞株の樹立

    山本英子、林加奈子、新美薫、炭竈誠二、小谷友美、吉川史隆

    第18回日本胎盤学会学術集会 

    　More details

    Event date： 2010.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  23. 胞状奇胎後経過非順調型症例の検討

    山本英子、林加奈子、近藤紳司、東真規子、稲葉智子、新美薫、井箟一彦、吉川史隆

    第48回日本婦人科腫瘍学会学術講演会 

    　More details

    Event date： 2010.7

    Language：Japanese   Presentation type：Poster presentation  

    Country：Japan  

  24. 胞状奇胎後hCG経過非順調型症例の検討

    山本　英子、井箟　一彦、近藤　紳司、新美　薫、林　加奈子、炭竈　誠二、小谷　友美、吉川　史隆

    第62回　日本産科婦人科学会学術講演会 

    　More details

    Event date： 2010.4

    Language：Japanese   Presentation type：Poster presentation  

    Country：Japan  

  25. 当院における胞状奇胎後hCG経過非順調型症例の検討：20週以降のhCG低単位持続症例の解析を含めて

    山本　英子、井箟 一彦、近藤　紳司、林　加奈子、新美　薫、吉川　史隆

    第27回　日本絨毛性疾患研究会学術集会 

    　More details

    Event date： 2009.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

    【目的】わが国の胞状奇胎管理では、娩出後hCG値推移が判別線を上回る場合を経過非順調型と分類し続発症の精査・治療対象となるが、病巣を認めない低単位hCG値の症例では治療開始の判断に迷う場合もある。そこで、経過非順調型の転機と治療有無について検討することを目的とした。【対象】当院にて2002年1月～2009年5月に、胞状奇胎術後管理あるいは侵入奇胎・絨毛癌・存続絨毛症として治療や経過観察を要した91症例を対象とした。娩出後hCG値の推移より順調型と非順調型に分け、非順調型では判別線を越える時期を8週までと8週以降に分け

  26. N-acetylglucosaminyltransferase V Regulates Extravillous Trophoblast Invasion through Glycosylation of α5β1 integrin International conference

    International Federation of Placenta Association 2008 

    　More details

    Event date： 2008.9

    Language：English   Presentation type：Oral presentation (general)  

  27. INVOLVEMENT OF OLIGOSACCHARIDE CHANGES IN α5β1 INTEGRIN IN INVASION OF EXTRAVILLOUS TROPHOBLASTS

    　More details

    Event date： 2007.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  28. TRNASCRIPTIONAL FACTOR IKAROS-X MIGHT BE INVOLVED IN MIGRATORY AND INVASIVE ABILITY IN EXTRAVILLOUS TROPHOBLASTS. International conference

    International Federation of Placenta Association 2005 

    　More details

    Event date： 2005.10

    Language：English   Presentation type：Oral presentation (general)  

    Objectives: Ikaros is a critical transcriptional factor in lymphopoiesis and there are more than 9 isoforms. We reported that Ikaros protein expressed in human placenta and isoform Ikaros-x (Ikx) was predominant in extravillous trophoblasts (EVTs). The aim of this work was to investigation the role of Ikx in EVTs. Methods: To suppress the normal ability of Ikx, we transfected a retrovirus vector expressing Ikaros-6 (dominant negative isoform) into the EVT cell line HTR-8/SVneo. Change of prolife

  29. CLINICAL CHARACTERISTICS OF PSTT AND ETT IN JAPAN International conference

    Niimi K., Yamamoto E., Nishino K., Nakamura K., Ikeda Y., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER  2018.9 

    　More details

    Language：English  

  30. Clinical features of gestational trophoblastic diseases in Japan Invited International coauthorship International conference

    Eiko Yamamoto

    IFPA 2018 Meeting  2018.9.23  IFPA

    　More details

    Language：English   Presentation type：Symposium, workshop panel (nominated)  

    Venue：Tokyo   Country：Japan  

  31. Quality of health services- Medical facilities and professions International conference

    Eiko Yamamoto

    International Symposium on Universal Health Coverage  2016.6.13  Nagoya University, Ministry of Health (Lao PDR)

    　More details

    Language：English   Presentation type：Symposium, workshop panel (nominated)  

    Venue：Vientiane Capital   Country：Lao People's Democratic Republic  

  32. A registration system and hCG check for hydatidiform mole patients for the eradication of choriocarcinoma Invited International conference

    Eiko Yamamoto

    Scientific meeting on Obstetrics-Gyne- cology Vietnam- Japan  2010.12.24 

    　More details

    Language：English   Presentation type：Oral presentation (invited, special)  

    Venue：Hanoi   Country：Viet Nam  

  33. Regulation system and the incidence of gestational trophoblastic disease in Japan Invited

    Ino Kazuhiko, Yamamoto Eiko, Kikkawa Fumitaka

    14th World Congress on Gestational Trophoblastic Diseases  2007.11.11 

    　More details

    Language：English   Presentation type：Oral presentation (invited, special)  

    Country：Japan  

  34. The role of N-acetylg lucosaminyltransferase IVa in choriocarcinoma progression

    Nishino Kimihiro, Yamamoto Eiko, Nakamura Kenichi, Niimi Kaoru, Kikkawa Fumitaka

    CANCER SCIENCE  2018.1 

  35. SHORT TANDEM REPEAT ANALYSIS DISTINGUISHING THE GENOTYPE OF CHORIOARCINOMA International conference

    Nishino K., Yamamoto E., Watanabe E., Nakamura K., Ikeda Y., Niimi K., Yamamoto T., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER  2018.9 

    　More details

    Language：English  

  36. ROLE OF GLYCOSYLTRANSFERASE C2GNT FOR THE EVASION MECHANISM OF NATURAL KILLER CELL IMMUNITY IN THE CHORIOCARCINOMA CELL International conference

    Nakamura K., Niimi K., NIshino K., Yamamoto E., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER  2017.11 

    　More details

    Language：English  

  37. ROLE OF CORE 2 beta 1, 6-N ACETYLGLCOSAMINYL TRANSFERASE IN EVASION MECHANISM THROUGH NK CELL IMMUNITY International conference

    NIimi Kaoru, Ikeda Yoshinori, Nishino Kimihiro, Yamamoto Eiko, Kikkawa Fumitaka

    PLACENTA  2018.9 

    　More details

    Language：English  

  38. ROLE OF CORE 2 beta 1, 6-N ACETYLGLCOSAMINYL TRANSFERASE IN EVASION MECHANISM THROUGH NK CELL IMMUNITY International conference

    Nakamura K., Kaoru N., Ikeda Y., Nishino K., Yamamoto E., KIkkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER  2018.9 

    　More details

    Language：English  

  39. LIGHT elevation underlies the sFlt-1 overproduction in patients with hydatidiform mole: An implication for the link between molar pregnancy and preeclampsia

    Matsui Haruka, Iriyama Takayuki, Wang Guan, Yoshikawa Midori, Niimi Kaoru, Yamamoto Eiko, Kotani Tomomi, Nagamatsu Takeshi, Koga Kawori, Osuga Yutaka, Fujii Tomoyuki

    JOURNAL OF REPRODUCTIVE IMMUNOLOGY  2018.11 

  40. GENETIC STUDY ON ORIGINS OF CHORIOCARCINOMAS BY SHORT TANDEM REPEAT ANALYSIS International conference

    Nishino Kimihiro, Nakamura Kenichi, Ikeda Yoshiki, Niimi Kaoru, Yamamoto Eiko, Yamamoto Toshimichi, Kikkawa Fumitaka

    PLACENTA  2018.9 

    　More details

    Language：English  

▼display all

To the head of Presentations.▲

Research Project for Joint Research, Competitive Funding, etc. 7

  1. ラオスにおける学齢期女性の月経時衛生管理改善を目指した学校保健教育の立案

    2021.4 - 2022.3

    アジア地域重点学術研究助成 

    山本英子、Alongkone Phengsavanh、Souphala Inthaphatha, Viengsakhone Louangpradith, Leyla Isin-Xiong

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\1481000 （ Direct Cost: \1481000 ）

  2. STR解析に基づいた絨毛癌の遺伝学的診断と新規治療薬の探索

    2018.4 - 2019.3

    第43回がんその他の悪性新生物研究助成金 

    山本英子、西野公博、新美薫、山本敏充

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\500000 （ Direct Cost: \500000 ）

    絨毛癌は妊娠性絨毛癌と非妊娠性絨毛癌に分類される。本研究では遺伝学的診断に基づいた非妊娠性絨毛癌、胞状奇胎由来妊娠性絨毛癌とそれ以外を由来とする妊娠性絨毛癌の化学療法有効性や予後を明らかにすることを目的とする。絨毛癌症例について、絨毛癌組織、患者およびパートナーから得たDNAを用いたSTR解析を行うことにより、絨毛癌が妊娠性かどうかの鑑別、妊娠性の場合には発生起源の妊娠が胞状奇胎（全胞状奇胎および部分胞状奇胎）、または、その他の妊娠かどうかの鑑別を行う。

  3. STR解析に基づいた絨毛癌の遺伝学的診断

    2017.4 - 2018.3

    第42回がんその他の悪性新生物研究助成金 

    山本英子

    　 More details

    Grant type：Competitive

    絨毛癌は妊娠性絨毛癌と非妊娠性絨毛癌に分類される。本研究では遺伝学的診断に基づいた非妊娠性絨毛癌、胞状奇胎由来妊娠性絨毛癌とそれ以外を由来とする妊娠性絨毛癌の化学療法有効性や予後を明らかにすることを目的とする。絨毛癌症例について、絨毛癌組織、患者およびパートナーから得たDNAを用いたSTR解析を行うことにより、絨毛癌が妊娠性かどうかの鑑別、妊娠性の場合には発生起源の妊娠が胞状奇胎（全胞状奇胎および部分胞状奇胎）、または、その他の妊娠かどうかの鑑別を行う。

  4. 絨毛癌根絶を目的とした胞状奇胎患者登録システムのベトナム北部への普及

    2010.9 - 2010.3

    八木基金　海外研究交流助成 

    　 More details

    Grant type：Competitive

    絨毛癌発症予防のために必要な胞状奇胎患者の管理法および登録システムは、日本では名古屋大学産婦人科学教室が確立し絨毛癌の発症および治療成績は飛躍的に改善した。ベトナム南部で行ってきた胞状奇胎患者の管理、登録を北部にも広げ、ベトナム全土における絨毛癌を日本と同様の治療成績および発症予防を目的として、ベトナム北部最大の都市であり南部とも合わせて中心的役割を果たす可能性のあるハノイ市の最大病院および大学において、教育と指導、管理センター設立の準備を行う。

  5. ベトナムにおける絨毛癌根絶のための胞状奇胎患者の管理と登録システムの普及

    2008.12 - 2010.3

    日東学術振興財団 

    　 More details

    Grant type：Competitive

    東南アジアでなど発展途上国では、絨毛癌の予後は不良だと言われている。ベトナムにおける絨毛癌の発生頻度および予後の詳細な調査は行われていない。日本では名古屋大学産婦人科が中心に、胞状奇胎患者を登録、管理することにより絨毛癌の発生および予後は劇的に改善した。ベトナムにおける絨毛癌根絶のため、胞状奇胎患者の診断、治療についての教育および管理登録システムの普及を目的とする。また、胞状奇胎および絨毛癌患者数、予後についての調査も同時に行う。

  6. ベトナムにおける産婦人科医療の教育と管理システム普及活動

    2008.4 - 2008.5

    国際共同研究 

    　 More details

    ベトナムにおける産婦人科医療の向上のため、疫学調査および治療技術の協力を行う。特に、絨毛性疾患については、絨毛癌の撲滅を目標として、当院が行っている胞状奇胎の診断および管理システムを教育、普及する。

  7. ヒト胎盤形成における糖転移酵素Ｇｎｔ－Ｖの機能と絨毛外栄養膜細胞浸潤機構の解明

    2006.7 - 2008.3

    学内共同研究 

▼display all

To the head of Research Project for Joint Research, Competitive Funding, etc..▲

KAKENHI (Grants-in-Aid for Scientific Research) 12

  1. アジア発展途上国における産後うつと危険因子に関する国際共同研究

    Grant number：23KK0169  2023.9 - 2029.3

    科学研究費助成事業  国際共同研究加速基金(海外連携研究)

    山本 英子

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\21060000 （ Direct Cost: \16200000 、 Indirect Cost：\4860000 ）

  2. Establishment of a Practical uninterrupted Skin-to-Skin Contact Education Program to Support Breastfeeding from Immediately After Birth

    Grant number：23K10130  2023.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    　 More details

    Authorship：Coinvestigator(s) 

  3. Developing an English for Medical Purposes (EMP) Massive Open Online Course (MOOC) for Japanese medical students

    Grant number：21K18371  2021.7 - 2024.3

    科学研究費助成事業  挑戦的研究(萌芽)

    CRIPPS Anthony, 山本 英子

    　 More details

    Authorship：Coinvestigator(s) 

    There are three distinct stages to the research project:
    <BR>
    Stage 1 - Conducting an in-depth analysis of the current state of EMP delivery at Japanese universities.
    Stage 2 - Designing and creating a pilot version of an EMP MOOC for Japanese medical students.
    Stage 3 - Monitoring the efficacy of the EMP MOOC and improving the EMP content based on feedback from students, educators, and in-service doctors.
    The researchers have started their in-depth investigation into the current state of English for Medical Purposes (EMP) delivery at Japanese universities. Research on existing online EMP support material which has been designed for medical students has begun. EMP educators and medical practitioners have been contacted with a view to setting up interviews on Japanese medical students’ EMP needs and possible content for the EMP MOOC.
    Due to the Corona virus epidemic interviews with EMP educators, medical practitioners, and members of the Japan Society for Medical English Education (JASMEE) had to be rescheduled for later this year.
    In stage 2, the researchers will design and create a pilot EMP MOOC. They will create unique and innovative material for the EMP MOOC. Such material will be related to separate units based on specific EMP themes. They will also conduct interviews with interviews with EMP educators, medical practitioners, and members of the Japan Society for Medical English Education (JASMEE)

  4. Establishment of a new tumor marker for trophoblastic neoplasia based on specific sugar chains of hCG

    Grant number：26462520  2014.4 - 2017.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Yamamoto Eiko

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）

    Choriocarcinoma cell line with GnT-IVa overexpression (Jar/GnT-IVa) was established and shRNA vectors were made for knockdown of GnT-III expression. GnT-III shRNA vectors were introduced into Jar/GnT-IVa. The levels of sugar chains were not changed by knockdown of GnT-III. Sandwich ELISA was performed using conditioned medium of Jar and GnT-IVa KD (Jar with knockdown of GnT-IVa expression), GSL-II lectin and a mouse antibody.
    Whole cell lysate and conditioned medium were collected from Jar/GnT-IVa and control cells. Nano-LC/MS/MS analysis using the proteins showed that LAMP-2 was a target molecule of GnT-IVa.

  5. The mechanism of carcinogenesis of choriocarcinoma with glycosyltransferases for hyperglycosylated hCG

    Grant number：23592445  2011 - 2013

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    YAMAMOTO Eiko, SHIBATA Kiyosumi

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\5200000 （ Direct Cost: \4000000 、 Indirect Cost：\1200000 ）

    The structures of sugar chains of hCG are quite different in trophoblastic neoplasia compared with normal pregnancy and hydatidiform mole, and it is because of N-acetylglucosaminyltransferase IVa (GnT-IVa)and core 2 beta-1, 6-N-acetylglucosaminyltransferase (C2GNT). The expression of GnT-IVa and C2GNT was strong in choriocarcinoma and invasive mole, but very weak in normal placenta and hydatidiform mole. The two glycosyltransferases involoved in promoting of invasion ability in choriocarcinoma. The result of immunoprecipitation suggested that Gnt-IVa promotes invasion ability via glycosylation of beta1 integrin. Luiferase assay suggested that cRel may regulate transcription of GnT-IVa via binding to the promoter of GnT-IVa.

  6. Research into the effects of defoliants used during the Vietnam War in the occurrence of congenital anomalies and tumors International coauthorship

    Grant number：22406028  2010 - 2012

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    NIIMI Teruyuki, KIKAWA Fumitaka, INOU Kazuhiko, NATSUME Nagato, YANAGISAWA Shigetaka, YAMAMOTO Eiko, FUJIWARA Kumiko, IMURA Hideto, KAJIYAMA Hiroki, KATSUKI Takeshi

    　 More details

    Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

    Grant amount：\9360000

    Incidence of congenital anomalies in Ben Tre province has declined in recent years. The causes, decrease of the effects of defoliants, improvement of maternal environment can be considered. On the other hand the possibility that abortion was also considered. Chorionic cancer was a downward trend. Be treated at the stage of the hydatidiform mole was considered as a cause.

  7. Regulation of trophoblast invasion by N-acetylglucosaminyltransferase in human placenta

    Grant number：21791548  2009 - 2010

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    YAMAMOTO Eiko

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）

    N-acetylglucosaminyltransferase V (GnT-V) is expressed in extravillous trophoblast (EVT) of human placenta in the first-trimester. We investigated factors which regulate expression of GnT-V in EVT cells using EVT cell line, HTR-8/SVneo. The supernatant of decidual tissue culture made GnT-V expression reduced and we confirmed TGF-b was the factor in cytokines. Hypoxia (1% Oxygen) promoted GnT-V expression in mRNA and protein levels after incubation for 48 hours compared to normoxia. Because GnT-V regulates trophoblast invasion by glycosylation of integrina5b1, we investigated the affection on phosphorylation of FAK after incubation with fibronectin. The result was that phosphorylation of FAK was reduced in GnT-V shRNA transfectants copared to control cells. We also investigated the difference of GnT-V expression between normal placentas and pregnancy-induced hypertension's ones, but there was no difference in immunohistochemistry and Western blot.

  8. Research into the effects of defoliants used during the Vietnam War in the occurrence of congenital anomalies and tumors

    Grant number：18406036  2006 - 2008

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    NIIMI Teruyuki, NATSUME Nagato, KATSUKI Takeshi, HIRAHARA Fumiki, GOTO Masaaki, KIKKAWA Fumitaka, INO Kazuhiko, KAJIYAMA Hiroaki, YAMAMOTO Eiko, YANAGISAWA Shigetaka, IMAI Yutaka, YAMADA Morimasa

    　 More details

    Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type：Competitive

    Grant amount：\7900000

  9. Functional role of IDO, a novel prognostic marker for endometrial cancer, and development of the tailor-made IDO-targeted therapy

    Grant number：18591831  2006 - 2008

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    INO Kazuhiko, YAMAMOTO Eiko, NOMURA Seiji

    　 More details

    Authorship：Coinvestigator(s)  Grant type：Competitive

    Grant amount：\3780000

  10. ヒト胎盤形成における糖転移酵素GnT-Vの機能と絨毛外栄養膜細胞浸潤機構の解明

    Grant number：18799005  2006 - 2007

    科学研究費助成事業  若手研究(B)

    山本 英子

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\3100000 （ Direct Cost: \3100000 ）

    GnT-V発現抑制絨毛外栄養膜細胞(EVT)モデルとして絨毛癌細胞株JarにsiRNAレトロウイルスベクターを遺伝子導入し、機能実験を行った。siGnT-V導入株ではmock株に比べて、MTS assayによる96時間までの増殖能に差は見られなかった。Migration assayおよびmatrigel invasion assayでは遊走細胞は2.1倍に、浸潤細胞は3.4倍に亢進した。
    GnT-V発現抑制による浸潤能促進機構を明らかにするために、zymographyによるmatrix metalloproteinase活性の変化を確認したが、MMP-2,MMP-9活性ともに変化は認めなかった。次に、細胞外基質への接着能を検討すると、ラミニン、フィブロネクチン、コラーゲンIおよびIVすべてにおいて接着能は亢進していた。絨毛細胞が浸潤能を持つEVTに分化するときには、膜表面に発現するインテグリンのサブタイプが基質の変化とともに変化し、浸潤に最も重要であるのはα5β1インテグンである。インテグリサブタイプの発現をフローサイトメトリーで確かめると、α1,α5,α6,β1インテグリンすべてに発現変化は認めなかった。しかし、α5β1インテグリンによる免疫沈降後にL_4-PHAを用いたレクチンブロットを行うと、α5β1インテグリンヘのβ1-6GlcNAc鎖付加レベルがGnT-V抑制株において明らかに抑制されていた。免疫沈降後に行ったα5、β1インテグリン抗体を用いたWesternblotでもそれぞれの蛋白発現レベルに変化は認めなかった。
    以上より、ヒトEVTにおいてはGnT-Vがα5β1インテグリンにβ1-6-G1cNAc鎖を付加することによって、浸潤を抑制している可能性が示唆された。細胞における分子の機能は、蛋白発現レベルのみでなく糖鎖修飾によってさらに制御されることは、今後の研究においても重要な視点である。

  11. A Comparative Study on the Promotion of Gender Equality in STEM Fields of Higher Education: An International Perspective

    Grant number：18KK0063  2018.10 - 2023.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

    　 More details

    Authorship：Coinvestigator(s) 

  12. Interdisciplinary study of obstetric management and gynecological rare tumor in Vietnam

    Grant number：15H02660  2015.4 - 2020.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)  Grant-in-Aid for Scientific Research (A)

    FUMITAKA KIKKAWA

    　 More details

    Authorship：Coinvestigator(s) 

    For the purpose of not only the development of obstetrics and gynecology in Vietnam, but also creation of evidence worldwide and building of medical research resources to Japan, we investigated obstetric management and gynecological rare tumor in Vietnam at several facilities in Vietnam. In the present study, several findings, which are related to improvement of mothers and children's prognosis,were gained. First, Pregnancy with dengue fever causes thrombocytopenia, which is at risk of postpartum hemorrhage. Second, cesarean section scar pregnancy with an increase in cesarean section rate in Vietnam, could be managed by medication for only selected patients. Third, evaluation of cardiac function by ultrasound examination for fetal growth restriction would be beneficial. Lastly, we found that there was a high secondary rate after molar pregnancy in Vietnam and preventive measures might improve it.

▼display all

To the head of KAKENHI (Grants-in-Aid for Scientific Research).▲
 

Teaching Experience (On-campus) 54

  1. Health Insurance and Economics

    2021

    　詳細を見る

    The aim is to understand the points needed for hospital administrators to manage a hospital in Japan.

  2. Administrative Regulations for Health

    2021

    　詳細を見る

    The overall aim of this unit is to understand the outline of Administrative Regulations for Health.

  3. Healthcare Service Facilities and Professionals

    2021

    　詳細を見る

    To understand 1) education, licensing, and services of each professional in Japan, 2) services of healthcare facilities in Japan, and 3) these in the YLP participants’ countries.

  4. 特徴あるプログラム/医学英語

    2021

  5. 特徴あるプログラム/医療行政学

    2021

  6. 基礎医学体験実習

    2021

  7. 基礎医学セミナー

    2021

  8. 社会医学実習

    2021

  9. セミナーIII

    2020

    　詳細を見る

    Reading Lancet Reviews

  10. 医療施設と医療従事者

    2020

  11. Healthcare Administration

    2020

  12. Social medical training

    2020

  13. Social medical training

    2020

  14. セミナーIII

    2019

    　詳細を見る

    Reading Lancet Reviews

  15. 医療施設と医療従事者

    2019

  16. Overseas Training Program

    2019

    　詳細を見る

    Overseas Training Program in Vietnam

  17. Basic training

    2019

    　詳細を見る

    Site visit on healthcare administration

  18. Healthcare Administration

    2019

  19. Medical English

    2019

  20. Social medical training

    2019

  21. Social medical training

    2019

  22. Social medical training

    2018

  23. セミナーIII

    2018

    　詳細を見る

    Reading Lancet Reviews

  24. 医療施設と医療従事者

    2018

  25. Overseas Training Program

    2018

    　詳細を見る

    Overseas Training Program in Cambodia

  26. Overseas Training Program

    2018

    　詳細を見る

    Overseas Training Program in Vietnam

  27. Basic training

    2018

    　詳細を見る

    Site visit on healthcare administration

  28. Healthcare Administration

    2018

  29. Medical English

    2018

  30. Social medical training

    2018

  31. Social medical training

    2017

  32. セミナーIII

    2017

    　詳細を見る

    Reading Lancet Reviews

  33. 医療施設と医療従事者

    2017

  34. Overseas Training Program

    2017

    　詳細を見る

    Overseas Training Program in Vietnam

  35. Basic training

    2017

    　詳細を見る

    Site visit on healthcare administration

  36. Healthcare Administration

    2017

  37. Medical English

    2017

  38. Social medical training

    2017

  39. Social medical training

    2016

  40. セミナーIII

    2016

    　詳細を見る

    Reading Lancet Reviews

  41. 医療施設と医療従事者

    2016

  42. Overseas Training Program

    2016

    　詳細を見る

    Overseas Training Program in Cambodia

  43. Overseas Training Program

    2016

    　詳細を見る

    Overseas Training Program in Vietnam

  44. Basic training

    2016

    　詳細を見る

    Site visit on healthcare administration

  45. Healthcare Administration

    2016

  46. Medical English

    2016

  47. Social medical training

    2016

  48. Social medical training

    2015

  49. セミナーIII

    2015

    　詳細を見る

    Reading Lancet Reviews

  50. Overseas Training Program

    2015

    　詳細を見る

    Overseas Training Program in Vietnam

  51. Basic training

    2015

    　詳細を見る

    Site visit on healthcare administration

  52. Healthcare Administration

    2015

  53. Medical English

    2015

  54. Overseas Training Program

    2014

    　詳細を見る

    Overseas Training Program in Vietnam

▼display all

To the head of Teaching Experience (On-campus).▲

Teaching Experience (Off-campus) 6

  1. 社会医学実習

    （名古屋大学医学部）

  2. 海外実地研修・Well-being in Asia

    （Nagoya University）

  3. 基礎医学セミナー

    （名古屋大学医学部）

  4. 医療行政学

    （名古屋大学大学院医学系研究科）

  5. 医学英語

    （名古屋大学大学院医学系研究科）

  6. ベーシックトレーニング・医療行政学

    （名古屋大学大学院医学系研究科）

▼display all

To the head of Teaching Experience (Off-campus).▲
 

Social Contribution 1

  1. アフガニスタン修了生への人道支援

    Role(s)：Advisor

    2021.8

To the head of Social Contribution.▲