Updated on 2025/04/02

写真a

 
YAMAMOTO Eiko
 
Organization
Graduate School of Medicine Program in Integrated Medicine Social Life Science Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Professor
Contact information
メールアドレス

Degree 2

  1. Bachelor(Medicine) ( 1996.3   Tokyo Medical and Dental University ) 

  2. 医学博士 ( 2006.3   名古屋大学 ) 

Research Interests 8

  1. Maternal and Child Health

  2. Gestational trophoblastic diseases

  3. Postpartum depression

  4. Gestational trophoblastic diseases

  5. Postpartum depression

  6. Maternal and child health

  7. Global health

  8. Asia

Research Areas 8

  1. Life Science / Obstetrics and gynecology  / Gestational trophoblastic disease

  2. Life Science / Obstetrics and gynecology  / Obstetrics and Gynecology

  3. Life Science / Hygiene and public health (non-laboratory)

  4. Life Science / Hygiene and public health (non-laboratory)

  5. Life Science / Hygiene and public health (non-laboratory)  / Global health

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Current Research Project and SDGs 4

  1. Prevention of choriocarcinoma in developing countries in Asia

  2. A Comparative Study on the Promotion of Gender Equality in STEM Fields of Higher Education: An International Perspective

  3. Factors associated with postpartum depression in Asian countries

  4. Menstrual hygiene management among girl students in Lao PDR

Research History 7

  1. Nagoya University   Professor

    2022.8

  2. Nagoya University   Department of Healthcare Administration   Professor

    2021.10

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    Country:Japan

  3. Nagoya University   Graduate School of Medicine Program in Integrated Medicine Social Life Science   Associate professor

    2016.4 - 2022.8

  4. Nagoya University   Department of Healthcare Administration   Associate professor

    2016.4 - 2021.9

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    Country:Japan

  5. Nagoya University   Asia Satellite Campus Institution   Designated associate professor

    2014.10 - 2016.3

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    Country:Japan

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Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    2002.4 - 2006.3

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    Country: Japan

  2. Tokyo Medical and Dental University   Faculty of Medicine

    1990.4 - 1996.3

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    Country: Japan

Professional Memberships 10

  1. 日本産科婦人科学会   評議員

    2015.1

  2. 日本婦人科腫瘍学会

  3. Japan Association of Gestational Trophoblastic Diseases

    2008.1

  4. 日本胎盤学会   理事

    2010.1

  5. Japan Association of International Health

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Committee Memberships 7

  1. Nagoya University   Gender Diversity Center  

    2022.4   

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    Committee type:Other

  2. 名古屋大学   アジア未来創造運営グループ  

    2021.10   

  3. 名古屋大学アジアサテライトキャンパス学院   運営委員会委員  

    2021.4   

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    Committee type:Other

  4. Nagoya University   The Nagoya University Ethics Committee (clinical intervention study)  

    2016.4 - 2018.3   

  5. 日本胎盤学会   理事  

    2016.1   

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    Committee type:Academic society

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Awards 4

  1. The Y.W. Loke Young Investigator Travel Award

    2005.9   International Federation of Placenta Association 2005  

  2. 相馬賞

    2007.11   日本胎盤学会  

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    Country:Japan

    最優秀演題賞

  3. The Y.W. Loke Young Investigator Travel Award

    2008.9   International Federation of Placenta Association 2008  

  4. 女性研究者トップリーダー顕彰

    2022.10   名古屋大学  

 

Papers 268

  1. *N-acetylglucosaminyltransferase V Regulates Extravillous Trophoblast Invasion through Glycosylation of alfa5beta1 integrin Reviewed

    Yamamoto E, Ino K, Miyoshi E, Inamori KI, Abe A, Sumigama S, Iwase A, Kajiyama H, Shibata K, Nawa A, Kikkawa F.

    Endocrinology   Vol. 150 ( 2 ) page: 990-999   2009

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    For successful human placentation, invasion of trophoblast cells into the uterus and its associated vasculature is essential, and the regulation of this process is controlled by many factors at the fetal-maternal interface. N-acetylglucosaminyltransferase V (GnT-V) is a key enzyme that catalyzes beta1, 6-N-acetylglucosamine (beta1-6GlcNAc) branching on asparagine-linked oligosaccharides of cell proteins. GnT-V and its product, beta1-6GlcNAc, are known to regulate cellular transformation and correlate with the metastatic potential of various cancer cells. The aim of the present study was to determine whether extravillous trophoblast (EVT) expressed this molecule and examine the role of GnT-V in the regulation of human trophoblast invasion. Immunohistochemistry showed that GnT-V was strongly expressed within the cytoplasm of EVT in the anchoring villi; this expression was down-regulated in EVTs invading the decidua. Suppression of beta1-6GlcNAc glycosylation by swainsonine enhanced the migratory potential and invasive capability of both primary EVTs and the EVT cell line, HTR-8/SVneo. Down-regulation of GnT-V expression by small interfering RNA in the choriocarcinoma cell line Jar consistently enhanced the migration and invasive capacity of these cells and elevated cellular adhesion to extracellular matrix proteins, such as fibronectin and collagen type I/IV. The extent of beta1-6 branching of alpha5beta1 integrin was significantly reduced in small interfering GnT-V-transfected Jar cells compared with mock transfectants, although the expression of alpha1, alpha5, alpha6, and beta1 integrin on the cell surface was not changed. These results suggest that GnT-V is expressed in human EVT and is involved in regulating trophoblast invasion through modifications of the oligosaccharide chains of alpha5beta1 integrin.

  2. *Ikaros is expressed in human extravillous trophoblasts and involved in their migration and invasion.

    Yamamoto E, Ito T, Abe A, Sido F, Ino K, Itakura A, Mizutani S, Dovat S, Nomura S, Kikkawa F.

    Molecular Human Reproduction   Vol. 11 ( 11 ) page: 825   2005.11

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    The transcriptional factor Ikaros was originally found to function as a key regulator of lymphocyte differentiation. In addition, we have reported that Ikaros regulates the human placental leucine aminopeptidase (P-LAP)/insulin-regulated aminopeptidase (IRAP) gene in choriocarcinoma trophoblastic cells, suggesting that Ikaros might be involved in placental development, while even its presence in human placenta remains undetermined. We therefore sought to clarify the location and roles of Ikaros in human placenta. Immunohistochemical analysis showed modest Ikaris expression in syncytium, and intense expression in extravillous trophoblasts (EVTs) in first trimester placenta. Western blot analysis showed that villous trophoblasts principally expressed Ikaros-2/3, while Ikaros-x (Ikx) was predominantly expressed in cultured EVTs. Furthermore, to investigate the functional role of Ikx in EVTs, the EVT cell line HTR-8/SVneo was infected with a retrovirus vector expressing the hemagglutinin (HA)-tagged dominant negative isoform Ikaros-6 (Ik6), which prevents the DNA-binding activity of Ikx. Antibody against HA showed successful transduction of Ik6 in HTR-8/SVneo cells on immunocytochemistry and Western blotting. Transduction of Ik6 significantly reduced the migratory and invasive abilities of HTR-8/SVneo cells. These results suggest that Ikx is involved in migration and invasion of EVTs in early placentation.

  3. *Expression of N-acetylglucosaminyltransferase V in Endometrial Cancer Correlates with Poor Prognosis Reviewed

    Yamamoto E, Ino K, Miyoshi E, Shibata K, Takahashi N, Kajiyama H, Nawa A, Nomura S, Nagasaka T, Kikkawa F

    British Journal of Cancer   Vol. 97 ( 11 ) page: 1538-1544   2007.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    N-acetylglucosaminyltransferase V (GnT-V) is an enzyme that catalyses beta1-6 branching of N-acetylglucosamine on asparagine-linked oligosaccharides of cell proteins. The present study aimed to investigate GnT-V expression and its prognostic significance in endometrial cancer. N-acetylglucosaminyltransferase V expression was studied by immunohistochemistry in 74 surgically resected endometrial cancers, and the staining intensity was evaluated. High GnT-V expression in tumour cells was found in 43 (58.1%) of the 74 cases, and was positively correlated with advanced patient age, histological grade, and lymph vascular space involvement. Patients with high GnT-V expression had significantly impaired overall survival and progression-free survival (PFS) (P=0.0041 and P=0.0023, respectively) compared to patients with low expression of GnT-V. On multivariate analysis, GnT-V expression was an independent prognostic factor for PFS (P=0.0364). beta1-6 branching of asparagine-linked oligosaccharides was also detected in GnT-V-positive endometrial cancer cells by leukoagglutinating phytohaemagglutinin (L(4)-PHA) staining, and the molecular size of the major glycoproteins recognised by L(4)-PHA was approximately 60-200 kDa by lectin blot analysis. These results suggested that high GnT-V expression was correlated with an unfavourable clinical outcome, and that GnT-V is involved in the malignant potential of endometrial cancer by increasing the synthesis of beta1-6 branching of asparagine-linked oligosaccharides.

  4. *A pure nongestational choriocarcinoma of the ovary diagnosed with short tandem repeat analysis: case report and review of the literature. Reviewed

    Yamamoto E, Ino K, Yamamoto T, Sumigama S, Nawa A, Nomura S, Kikkawa F.

    International Journal of Gynecologic Cancer   Vol. 17 ( 1 ) page: 254-8   2007.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Nongestational pure choriocarcinoma of the ovary is a very rare germ cell tumor. Except in women before menarche, determination of the origin is very difficult without genetic analysis. We present a pure nongestational choriocarcinoma arising in the left ovary of a 19-year-old woman. Following surgery, pathologic findings of the tumor demonstrated pure choriocarcinoma without combination of other germ cell tumor elements. We confirmed its nongestational origin by DNA polymorphism analysis at 15 short tandem repeat loci. Multiple courses of chemotherapy with methotrexate, etoposide, and actinomycin-D were effective for this case. DNA polymorphism analysis is useful to determine genetic origin in pure choriocarcinoma of the ovary.

  5. Activator protein-2 impairs the invasion of a human extravillous trophoblast cell line. Reviewed

    Kotani Tomomi, Iwase Akira, Ino Kazuhiko, Sumigama Seiji, Yamamoto Eiko, Hayakawa Hiromi, Nagasaka Toshiro, Itakura Atsuo, Nomura Seiji, Kikkawa Fumitaka.

    Endocrinology   Vol. 150 ( 9 ) page: 4376-4385   2009.11

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    The reduced migration/invasion of extravillous trophoblasts (EVTs) is a key feature of the genesis of preeclampsia. We and others previously reported that transcriptional factors activator protein-2 (AP-2) alpha and AP-2gamma act as suppressors of tumor invasion. The present study examined the expressions of AP-2alpha and AP-2gamma in preeclamptic placenta vs. control placenta and investigated their effect on the function of EVTs. The expressions of AP-2alpha and AP-2gamma were elevated in the preeclamptic placentas in comparison with the gestational age-matched control placentas. Their expressions also increased in EVTs of the preeclamptic placentas. Thereafter, we transfected AP-2alpha or AP-2gamma into human EVT cell line, HTR-8/SVneo. The overexpression of AP-2alpha or AP-2gamma decreased the migratory and invasive abilities in HTR-8/SVneo cells. This was followed by the reduction of protease activated receptor-1 and matrix metalloproteinases and a significant induction of plasminogen activator inhibitor-1 and the tissue inhibitor of metalloproteinase-1. AP-2alpha and AP-2gamma were weakly expressed in the cultured EVTs and HTR-8/SVneo cells, whereas they were induced by TNF-alpha, which increases in preeclamptic placenta and impairs trophoblast invasion. In the presence of TNF-alpha, the invasion of the HTR-8/SVneo cells was partially restored by a blocking of AP-2 induction using small interfering RNA of AP-2. The present data suggest that AP-2 may suppress trophoblast migration and invasion, thus leading to a shallow placentation in preeclampsia.

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Books 28

  1. 今日の治療指針(福井次矢、高木誠、小室一成総編集).

    山本英子( Role: Contributor ,  絨毛性疾患.)

    医学書院  2020 

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    Language:Japanese

  2. 産婦人科処方のすべて2020(大道正英、亀井良政、久慈直昭編集).

    新美薫、山本英子、梶山広明.( Role: Contributor ,  絨毛性疾患.)

    医学書院  2020 

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    Language:Japanese

  3. やさしくわかる産科婦人科検査マスターブック(大須賀譲、高松潔、田中守、渡部洋編集).

    山本英子、新美薫、西野公博.( Role: Contributor ,  絨毛性疾患のhCG.)

    診断と治療社  2020 

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    Language:Japanese

  4. 産科婦人科疾患最新の治療2019-2021(吉川史隆、平松裕司、大須賀譲編集).

    新美薫、山本英子.( Role: Contributor ,  絨毛性疾患.)

    南江堂  2019 

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    Language:Japanese

  5. 現代の母性看護(入山茂美、春名めぐみ、大林陽子編).

    ( Role: Contributor)

    名古屋大学出版会  2019 

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    Language:Japanese

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MISC 1

  1. 孤発性肺転移病巣の再燃を繰り返す妊娠性絨毛癌に対して,手術が有効であった1例

    西子 裕規, 新美 薫, 柴田 真由, 市川 義一, 小田 結加里, 渡邉 絵里, 西野 公博, 山本 英子, 梶山 広明

    日本婦人科腫瘍学会学術講演会プログラム・抄録集   Vol. 64回   page: 289 - 289   2022.7

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    Language:Japanese   Publisher:(公社)日本婦人科腫瘍学会  

Presentations 40

  1. Proposal for guideline for management of gestational trophoblastic disease in Cambodia Invited International conference

    Eiko Yamamoto

    Society of Cambodian Gynecology Oncology 18th Annual Conference  2019.11.23  Society of Cambodian Gynecology Oncology

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    Event date: 2019.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Phnom Penh   Country:Cambodia  

  2. Clinical management of trophoblastic diseases Invited International conference

    Eiko Yamamoto

    Society of Cambodian Gynecology Oncology 16th Annual Conference  2017.11.27  Society of Cambodian Gynecology Oncology

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    Event date: 2017.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Phnom Penh   Country:Cambodia  

  3. Expression of N-acetylglucosaminyltransferase IVa in extravillous trophoblast and gestational trophoblastic disease International conference

    International Federation of Placenta Association 2009 

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    Event date: 2009.10

    Language:English   Presentation type:Poster presentation  

    Objectives: Hyperglycosylated hCG (hCG-H) is a glycoprotein variant of the hormone hCG and reported to be detected in serum and urine of early pregnant women, invasive mole and choriocarcinoma, but not of molar patients. N-acetylglucosaminyltransferase IVa (GnT-IVa) is one of glycosyltransferases to attach abnormal biantennary N-linked sugar chains to hCG. Our aim is to clarify the expression of GnT-IVa in gestational trophoblastic disease and extravillous trophoblasts (EVTs) in human placenta.

  4. English education and programs for studying abroad of Nagoya University Graduate School of Medicine International conference

    INTERNATIONAL CONFERENCE ON ‘ADVANCES IN EDUCATION, TEACHING AND LEARNING’  2021.12.3  Mongolian National University of Medical Sciences

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    Event date: 2021.12

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Ulaanbaatar (Hybrid)   Country:Mongolia  

  5. 日本の絨毛性疾患の特徴と発生率の推移:絨毛性疾患地域登録データ解析より

    山本英子

    第39回絨毛性疾患研究会  2021.11.26  東京薬科大学

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    Event date: 2021.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京   Country:Japan  

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Research Project for Joint Research, Competitive Funding, etc. 7

  1. ラオスにおける学齢期女性の月経時衛生管理改善を目指した学校保健教育の立案

    2021.4 - 2022.3

    アジア地域重点学術研究助成 

    山本英子、Alongkone Phengsavanh、Souphala Inthaphatha, Viengsakhone Louangpradith, Leyla Isin-Xiong

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\1481000 ( Direct Cost: \1481000 )

  2. STR解析に基づいた絨毛癌の遺伝学的診断と新規治療薬の探索

    2018.4 - 2019.3

    第43回がんその他の悪性新生物研究助成金 

    山本英子、西野公博、新美薫、山本敏充

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\500000 ( Direct Cost: \500000 )

    絨毛癌は妊娠性絨毛癌と非妊娠性絨毛癌に分類される。本研究では遺伝学的診断に基づいた非妊娠性絨毛癌、胞状奇胎由来妊娠性絨毛癌とそれ以外を由来とする妊娠性絨毛癌の化学療法有効性や予後を明らかにすることを目的とする。絨毛癌症例について、絨毛癌組織、患者およびパートナーから得たDNAを用いたSTR解析を行うことにより、絨毛癌が妊娠性かどうかの鑑別、妊娠性の場合には発生起源の妊娠が胞状奇胎(全胞状奇胎および部分胞状奇胎)、または、その他の妊娠かどうかの鑑別を行う。

  3. STR解析に基づいた絨毛癌の遺伝学的診断

    2017.4 - 2018.3

    第42回がんその他の悪性新生物研究助成金 

    山本英子

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    Grant type:Competitive

    絨毛癌は妊娠性絨毛癌と非妊娠性絨毛癌に分類される。本研究では遺伝学的診断に基づいた非妊娠性絨毛癌、胞状奇胎由来妊娠性絨毛癌とそれ以外を由来とする妊娠性絨毛癌の化学療法有効性や予後を明らかにすることを目的とする。絨毛癌症例について、絨毛癌組織、患者およびパートナーから得たDNAを用いたSTR解析を行うことにより、絨毛癌が妊娠性かどうかの鑑別、妊娠性の場合には発生起源の妊娠が胞状奇胎(全胞状奇胎および部分胞状奇胎)、または、その他の妊娠かどうかの鑑別を行う。

  4. 絨毛癌根絶を目的とした胞状奇胎患者登録システムのベトナム北部への普及

    2010.9 - 2010.3

    八木基金 海外研究交流助成 

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    Grant type:Competitive

    絨毛癌発症予防のために必要な胞状奇胎患者の管理法および登録システムは、日本では名古屋大学産婦人科学教室が確立し絨毛癌の発症および治療成績は飛躍的に改善した。ベトナム南部で行ってきた胞状奇胎患者の管理、登録を北部にも広げ、ベトナム全土における絨毛癌を日本と同様の治療成績および発症予防を目的として、ベトナム北部最大の都市であり南部とも合わせて中心的役割を果たす可能性のあるハノイ市の最大病院および大学において、教育と指導、管理センター設立の準備を行う。

  5. ベトナムにおける絨毛癌根絶のための胞状奇胎患者の管理と登録システムの普及

    2008.12 - 2010.3

    日東学術振興財団 

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    Grant type:Competitive

    東南アジアでなど発展途上国では、絨毛癌の予後は不良だと言われている。ベトナムにおける絨毛癌の発生頻度および予後の詳細な調査は行われていない。日本では名古屋大学産婦人科が中心に、胞状奇胎患者を登録、管理することにより絨毛癌の発生および予後は劇的に改善した。ベトナムにおける絨毛癌根絶のため、胞状奇胎患者の診断、治療についての教育および管理登録システムの普及を目的とする。また、胞状奇胎および絨毛癌患者数、予後についての調査も同時に行う。

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KAKENHI (Grants-in-Aid for Scientific Research) 14

  1. International collaborative study on risk factors of postpartum depression in Asian developing countries

    Grant number:23KK0169  2023.9 - 2029.3

    Grants-in-Aid for Scientific Research  Fund for the Promotion of Joint International Research (International Collaborative Research)

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\21060000 ( Direct Cost: \16200000 、 Indirect Cost:\4860000 )

  2. Social implementation study of community comprehensive mental health care in maternal and child health policy International coauthorship

    Grant number:24K13288  2024.4 - 2028.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

  3. 在留外国人妊婦の不安・負荷・アンメットニーズを包括的に理解するための基盤研究

    Grant number:24K13287  2024.4 - 2027.3

    科学研究費助成事業  基盤研究(C)

    西野 公博, 山本 英子

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    少子化が進む日本において、在留外国人妊婦による出生件数が近年増加しているが、在留外国人妊婦は妊娠、分娩にあたり、どのような点を不安や不満に思い、困難に感じ、それらがどのような負荷となって表れているのか、増加する在留外国人妊婦による出生に対して、医療従事者、医療施設、国(政府)や地方自治体などの医療行政機関は、在留外国人妊婦の不安やニーズに十分に対応できているのか、こうした問いに対して、本研究では、厚生労働省人口動態調査の調査票情報の利用や、医療施設、及び、在留外国人妊婦へのアンケート調査を通じて、答えやヒントとなるものを見出すことを目的として、研究を行う。

  4. Establishment of a Practical uninterrupted Skin-to-Skin Contact Education Program to Support Breastfeeding from Immediately After Birth

    Grant number:23K10130  2023.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s) 

  5. Establishment of a new tumor marker for trophoblastic neoplasia based on specific sugar chains of hCG

    Grant number:26462520  2014.4 - 2017.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Yamamoto Eiko

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4940000 ( Direct Cost: \3800000 、 Indirect Cost:\1140000 )

    Choriocarcinoma cell line with GnT-IVa overexpression (Jar/GnT-IVa) was established and shRNA vectors were made for knockdown of GnT-III expression. GnT-III shRNA vectors were introduced into Jar/GnT-IVa. The levels of sugar chains were not changed by knockdown of GnT-III. Sandwich ELISA was performed using conditioned medium of Jar and GnT-IVa KD (Jar with knockdown of GnT-IVa expression), GSL-II lectin and a mouse antibody.
    Whole cell lysate and conditioned medium were collected from Jar/GnT-IVa and control cells. Nano-LC/MS/MS analysis using the proteins showed that LAMP-2 was a target molecule of GnT-IVa.

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Teaching Experience (On-campus) 54

  1. 基礎医学体験実習

    2021

  2. 基礎医学セミナー

    2021

  3. 社会医学実習

    2021

  4. 特徴あるプログラム/医療行政学

    2021

  5. Health Insurance and Economics

    2021

     詳細を見る

    The aim is to understand the points needed for hospital administrators to manage a hospital in Japan.

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Teaching Experience (Off-campus) 5

  1. 社会医学実習

    名古屋大学医学部)

  2. 基礎医学セミナー

    名古屋大学医学部)

  3. 医療行政学

    名古屋大学大学院医学系研究科)

  4. 医学英語

    名古屋大学大学院医学系研究科)

  5. ベーシックトレーニング・医療行政学

    名古屋大学大学院医学系研究科)

 

Social Contribution 1

  1. アフガニスタン修了生への人道支援

    Role(s):Advisor

    2021.8