研究者詳細 - 有馬　寛

論文 - 有馬　寛

分割表示 294 件中 81 - 100 件目／全件表示 >>

Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis 査読有り

Ryuge, A; Kosugi, T; Maeda, K; Banno, R; Gou, Y; Zaitsu, K; Ito, T; Sato, Y; Hirayama, A; Tsubota, S; Honda, T; Nakajima, K; Ozaki, T; Kondoh, K; Takahashi, K; Kato, N; Ishimoto, T; Soga, T; Nakagawa, T; Koike, T; Arima, H; Yuzawa, Y; Minokoshi, Y; Maruyama, S; Kadomatsu, K

JCI INSIGHT 6 巻 ( 20 ) 2021年10月

Adult-onset autoimmune diabetes identified by glutamic acid decarboxylase autoantibodies: a retrospective cohort study 査読有り国際誌

Wada, E; Onoue, T; Kinoshita, T; Hayase, A; Handa, T; Ito, M; Furukawa, M; Okuji, T; Kobayashi, T; Iwama, S; Sugiyama, M; Takagi, H; Hagiwara, D; Suga, H; Banno, R; Goto, M; Arima, H

DIABETOLOGIA 64 巻 ( 10 ) 頁： 2183 - 2192 2021年10月

GABAB receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice 査読有り国際共著国際誌

Sun, RN; Tsunekawa, T; Hirose, T; Yaginuma, H; Taki, K; Mizoguchi, A; Miyata, T; Kobayashi, T; Sugiyama, M; Onoue, T; Takagi, H; Hagiwara, D; Ito, Y; Iwama, S; Suga, H; Banno, R; Bettler, B; Arima, H

SCIENTIFIC REPORTS 11 巻 ( 1 ) 頁： 19296 - 19296 2021年9月

Prevention of Worsening Diabetes through Behavioral Changes by an IoT-based Self-Monitoring System in Japan (PRISM-J): Study design and rationale for a multicenter, open-label, randomized parallel-group trial.

Bouchi R, Izumi K, Ohtsu H, Miyo K, Tanaka S, Satoh-Asahara N, Hara K, Odawara M, Kusunoki Y, Koyama H, Onoue T, Arima H, Tsushita K, Watada H, Kadowaki T, Ueki K

GHM open 1 巻 ( 1 ) 頁： 3 - 11 2021年8月

Deficiency of WFS1 leads to the impairment of AVP secretion under dehydration in male mice 査読有り国際誌

Kurimoto, J; Takagi, H; Miyata, T; Hodai, Y; Kawaguchi, Y; Hagiwara, D; Suga, H; Kobayashi, T; Sugiyama, M; Onoue, T; Ito, Y; Iwama, S; Banno, R; Tanabe, K; Tanizawa, Y; Arima, H

PITUITARY 24 巻 ( 4 ) 頁： 582 - 588 2021年8月

Prediabetes is associated with proteinuria development but not with glomerular filtration rate decline: A longitudinal observational study 査読有り

Furukawa, M; Onoue, T; Kato, K; Wada, T; Shinohara, Y; Kinoshita, F; Goto, M; Arima, H; Tsushita, K

DIABETIC MEDICINE 38 巻 ( 8 ) 頁： e14607 2021年8月

Preoperative and long-term efficacy and safety of lanreotide autogel in patients with thyrotropin-secreting pituitary adenoma: a multicenter, single-arm, phase 3 study in Japan. 招待有り国際共著

Shimatsu A, Nakamura A, Takahashi Y, Fujio S, Satoh F, Tahara S, Nishioka H, Takano K, Yamashita M, Arima H, Tominaga A, Tateishi S, Matsushita Y

Endocrine journal 68 巻 ( 7 ) 頁： 791 - 805 2021年7月

Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice 査読有り国際誌

Mizoguchi, A; Banno, R; Sun, R; Yaginuma, H; Taki, K; Kobayashi, T; Sugiyama, M; Tsunekawa, T; Onoue, T; Takagi, H; Hagiwara, D; Ito, Y; Iwama, S; Suga, H; Nagai, T; Yamada, K; Arima, H

SCIENTIFIC REPORTS 11 巻 ( 1 ) 頁： 12873 - 12873 2021年6月

Comparison of High-Resolution Manometry in Patients Complaining of Dysphagia among Patients with or without Diabetes Mellitus 査読有り国際誌

Muroi, K; Miyahara, R; Funasaka, K; Furukawa, K; Sawada, T; Maeda, K; Yamamura, T; Ishikawa, T; Ohno, E; Nakamura, M; Kawashima, H; Onoue, T; Arima, H; Hirooka, Y; Fujishiro, M

DIGESTION 102 巻 ( 4 ) 頁： 554 - 562 2021年6月

【内分泌疾患2】(Part 2)どこまでを専門家がみて,どこから総合内科医がみるのか? 下垂体中枢性尿崩症,SIADH

須賀英隆, 高木博史, 有馬寛

Hospitalist 9 巻 ( 2 ) 頁： 417 - 423 2021年6月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：(株)メディカル・サイエンス・インターナショナル

＜文献概要＞key point 中枢性尿崩症 ▼尿崩症を疑うきっかけの多くは多尿であるが,頻尿との判別に注意する。▼多尿の症例では尿浸透圧を評価し,低浸透圧尿であれば,内分泌専門医へ紹介する。▼デスモプレシン(経鼻製剤または経口製剤)による治療が開始され,その管理を内分泌専門医から引き継いだ場合,薬効が切れて尿量が増加する時間帯を適宜設けさせ,過量投与による水中毒の発生を回避する。特に渇感障害を合併する症例は管理が難しく,毎日の体重測定が投与量調整に有効である。抗利尿ホルモン分泌過剰症(SIADH) ▼SIADHを疑うきっかけは,主に低ナトリウム血症であり,無症状のことが多いが,重症例や急速進行例では倦怠感などの症状を呈することがある。▼水分制限を実施しても低ナトリウム血症が改善しない症例は,内分泌専門医に紹介する。▼内分泌専門医からトルバプタンによる治療を引き継いだ場合,状況に合わせた飲水方針を決定したうえで,血清ナトリウム値の定期フォローを行う。

Efficacies of programmed cell death 1 ligand 1 blockade in non-small cell lung cancer patients with acquired resistance to prior programmed cell death 1 inhibitor and development of diabetic ketoacidosis caused by two different etiologies: a retrospective case series. 査読有り

Ishi A, Tanaka I, Iwama S, Sakakibara T, Mastui T, Kobayashi T, Hase T, Morise M, Sato M, Arima H, Hashimoto N

Endocrine journal 68 巻 ( 5 ) 頁： 613 - 620 2021年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本内分泌学会

The programmed cell death 1 (PD-1)/programmed cell death 1 ligand 1 (PD-L1) axis is vital for immune resistance during tumor development, while PD-L1 inhibitors can also inhibit the PD-L1/B7-1 (CD80) interaction, indicating one of the molecular differences between PD-1 and PD-L1 inhibitors. However, the clinical benefits of PD-L1 inhibitors in patients previously treated with PD-1 inhibitors remain unknown. In this study, we retrospectively analyzed the clinical data of eight patients with non-small cell lung cancer who received the PD-L1 inhibitor atezolizumab and previously treated with the PD-1 inhibitor nivolumab. The median progression-free survival was 2.1 months (1.8–18.7 months), and 4 of 8 patients achieved at least stable disease. In two of these patients, atezolizumab treatment resulted in longer progression-free survival (PFS) compared with that of nivolumab. Conversely, one patient exhibited grade 4 diabetic ketoacidosis (DKA) within 2 weeks after the initial administration of atezolizumab. Another patient had developed type 1 diabetes mellitus (T1DM) during the prior nivolumab treatment and then developed DKA due to an infection after the initiation of atezolizumab. Both of them had high-risk human leukocyte antigen-DR/DQ types relevant to T1DM. These results demonstrate the potential efficacy of PD-L1 inhibitors to some tumors that have acquired resistance to PD-1 inhibitors and suggest that appropriate managements are required for not only a newly onset of T1DM but also blood glucose control after the development of T1DM during a reiteration of the PD-1/PD-L1 blockade.

DOI： 10.1507/endocrj.EJ20-0769

PubMed

Macrophages rely on extracellular serine to suppress aberrant cytokine production 査読有り

Kurita, K; Ohta, H; Shirakawa, I; Tanaka, M; Kitaura, Y; Iwasaki, Y; Matsuzaka, T; Shimano, H; Aoe, S; Arima, H; Ogawa, Y; Ito, A; Suganami, T

SCIENTIFIC REPORTS 11 巻 ( 1 ) 頁： 11137 2021年5月

A new primate model of hypophyseal dysfunction

Kawabata, T; Suga, H; Takeuchi, K; Nagata, Y; Sakakibara, M; Ushida, K; Ozone, C; Enomoto, A; Kawamoto, I; Itagaki, I; Tsuchiya, H; Arima, H; Wakabayashi, T

SCIENTIFIC REPORTS 11 巻 ( 1 ) 頁： 10729 2021年5月

CD4+ T cells are essential for the development of destructive thyroiditis induced by anti-PD-1 antibody in thyroglobulin-immunized mice 査読有り国際誌

Yasuda, Y; Iwama, S; Sugiyama, D; Okuji, T; Kobayashi, T; Ito, M; Okada, N; Enomoto, A; Ito, S; Yan, Y; Sugiyama, M; Onoue, T; Tsunekawa, T; Ito, Y; Takagi, H; Hagiwara, D; Goto, M; Suga, H; Banno, R; Takahashi, M; Nishikawa, H; Arima, H

SCIENCE TRANSLATIONAL MEDICINE 13 巻 ( 593 ) 2021年5月

High-fat Feeding Causes Inflammation and Insulin Resistance in the Ventral Tegmental Area in Mice 国際誌

Mizoguchi, A; Banno, R; Sun, RN; Yaginuma, H; Taki, K; Kobayashi, T; Sugiyama, M; Tsunekawa, T; Onoue, T; Takagi, H; Hagiwara, D; Ito, Y; Iwama, S; Suga, H; Arima, H

NEUROSCIENCE 461 巻頁： 72 - 79 2021年5月

Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors 査読有り

Kobayashi, T; Iwama, S; Sugiyama, D; Yasuda, Y; Okuji, T; Ito, M; Ito, S; Sugiyama, M; Onoue, T; Takagi, H; Hagiwara, D; Ito, Y; Suga, H; Banno, R; Nishikawa, H; Arima, H

JOURNAL FOR IMMUNOTHERAPY OF CANCER 9 巻 ( 5 ) 頁： e002493 - e002493 2021年5月

Arginine vasopressin-Venus reporter mice as a tool for studying magnocellular arginine vasopressin neurons 国際誌

Hagiwara, D; Tochiya, M; Azuma, Y; Tsumura, T; Hodai, Y; Kawaguchi, Y; Miyata, T; Kobayashi, T; Sugiyama, M; Onoue, T; Takagi, H; Ito, Y; Iwama, S; Suga, H; Banno, R; Arima, H

PEPTIDES 139 巻頁： 170517 - 170517 2021年5月

Clinical Characteristics, Management, and Potential Biomarkers of Endocrine Dysfunction Induced by Immune Checkpoint Inhibitors 招待有り査読有り

Iwama, S; Kobayashi, T; Arima, H

ENDOCRINOLOGY AND METABOLISM 36 巻 ( 2 ) 頁： 312 - 321 2021年4月

イピリムマブ誘発下垂体炎発症者で高抗体価を示す自己抗体の同定査読有り

奥地剛之, 岩間信太郎, 周キン, 伊藤雅晃, 小林朋子, 安田康紀, 有馬寛

日本内分泌学会雑誌 97 巻 ( 1 ) 頁： 262 - 262 2021年4月

抗PD-1抗体誘発甲状腺炎マウスモデルにおける抗サイログロブリン抗体の役割査読有り

安田康紀, 岩間信太郎, 伊藤雅晃, 奥地剛之, 小林朋子, 有馬寛

日本内分泌学会雑誌 97 巻 ( 1 ) 頁： 267 - 267 2021年4月

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