Updated on 2021/03/24

写真a

 
YOKOYAMA, Yukihiro
 
Organization
Graduate School of Medicine Department of Surgery, Division of Perioperative Medicine Endowed Chair Designated professor
Title
Designated professor
Contact information
メールアドレス

Degree 4

  1. Bachelor of Mechanical Engineering ( 1983.3 ) 

  2. Doctor of Medicine ( 1992.5   Nagoya University ) 

  3. Ph.D. in Biology/Physiology ( 2001.4   University of North Carolina at Charlotte ) 

  4. Doctor (Medicine) ( 2010.12   Nagoya University ) 

Research Interests 1

  1. Surgical Oncology/Hepatobiliary Pancreatic Surgery and Liver Physiology

Research Areas 1

  1. Others / Others  / Digestive Organ Surgery

Current Research Project and SDGs 22

  1. The role of estrogen in the process of liver regeneration.

  2. The effect of renal dysfunction on the process of liver regeneration.

  3. The importance of intestine in the process of liver regeneration.

  4. A study of early signal in the process ofliver regeneration using non-stress portal branch ligation model.

  5. The role of PPAR gamma in the process of hepatic injury following bile duct ligation.

  6. The role of Hedgehog Signal in the growth of cholangiocarcinoma.

  7. 閉塞性黄疸に対するインチンコウトウ投与の意義

  8. Nek2遺伝子を用いた癌分子標的治療の開発

  9. 肝再生早期におけるカルシトニンの役割とその分子機構

  10. シンバイオティックスにより周術期合併症の予防効果に関する前向き研究

  11. 複数の癌特異的遺伝子を標的にした分子標的治療の開発

  12. The value of Braun anastomosis in preventing delayed gastric emptying following pancreatoduodenectomy; the study of intragastric bile regurgitation using pH bilitec.

  13. 胆管癌における術前胆汁細胞診の精度向上と定型化

  14. Effects of perioperative administration of branched-chain amino acid (BCAA) on intraoperative vital sign and postoperative recovery in major hepatectomy.

  15. Development of high sensitive diagnostic system for hepato-biliary-pancreatic malignancies.

  16. Detection of intraoperative bacterial translocation in patients who undergo hepatectomy with extrahepatic bile duct resection or pancreatoduodenectomy.

  17. Impact of the gastro-jejunal anatomical position on the incidence of delayed gastric emptying following pancreatoduodenectomy.

  18. The study for the effects of intestinal microenvironment on the choleretic effect of Inchinkoto, a herbal medicine.

  19. Phase II study of neoadjuvant FOLFIRINOX or nab-paclitaxel with gemcitabine for borderline resectable pancreatic cancer

  20. The investigation for the association between the choleretic effects of Inchinkoto and intestinal microenvironment in patients with obstructive jaundice

  21. The study for the hepatoprotective effect of steroid administration before hepatectomy in major hepatectomy with extrahepatic bile duct resection

  22. The investigation for the impact of preoperative physical and nutritional support on the muscle strength and muscle mass, and the incidence of postoperative complications following highly invasive surgeries.

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Research History 11

  1. 名古屋大学医学部附属病院消化器外科一 講師

    2011.4

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    Country:Japan

  2. 名古屋大学大学院医学系研究科 外科感染症学寄附講座 講師

    2009.10

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    Country:Japan

  3. Nagoya University Graduate School of Medicine, Department of Surgery, Division of Surgical Oncology: Assistant Professor

    2005.10

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    Country:Japan

  4. Kasugai Municipal Hospital

    2005.4 - 2005.9

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    Country:Japan

  5. Nagoya University Graduate School of Medicine, Department of Surgery, Division of Surgical Oncology

    2004.1 - 2005.3

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    Country:Japan

  6. Aichi Saiseikai Hospital (Nagoya, Japan)

    2002.9 - 2003.12

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    Country:Japan

  7. Postdoctoral research fellow (University of Alabama at Birmingham, Center of Surgical Research, Department of Surgery)

    2001.7 - 2002.8

  8. Adjunct Associate Researcher (University of North Carolina at Charlotte)

    1998.4 - 2000.6

  9. Nagoya University 1st Dept of Surg

    1998.1 - 1998.3

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    Country:Japan

  10. Kiryu Kosei General Hospital (Gunma, Japan)

    1996.7 - 1997.12

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    Country:Japan

  11. Ohgaki Municipa Hospital (Gifu, Japan)

    1993.4 - 1996.6

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    Country:Japan

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Education 3

  1. University of North Carolina at Charlotte   Biology Department   Biology/Physiology

    1999.1 - 2001.5

  2. Nagoya University   Faculty of Medicine

    1988.4 - 1992.3

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    Country: Japan

  3. Kanazawa University   Faculty of Engineering

    1979.4 - 1983.3

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    Country: Japan

Professional Memberships 24

  1. Japan Surgical Society

    2007.4

  2. The Japanese Society of Gastroenterological Surgery

    2007.4

  3. The Japanese Society of Gastroenterological Surgery

    2011.1

  4. Japanese Association for Acute Medicine

    2004.1

  5. Japan Surgical Association

    2010.4

  6. The Japanese Society of Gastroenterology

    2009.4

  7. Japanese Society of Hepato-biliary -Pancreatic Surgery

    2008.4

  8. Japanese Society for Endoscopic Surgery

    2005.1

  9. Japan Pancreas Society

    2006.1

  10. Japanese Biliary Association

    2006.1

  11. Japanese Cancer Association

    2007.1

  12. Japan Society for Surgical Infection

    2009.1

  13. Shock Society

    2001.1

  14. The American Physiological Society

    2004.1

  15. The American College of Surgeons (FACS)

    2008.4

  16. International Hepato-Pancreato-Biliary Association (IHPBA)

    2008.1

  17. The American Association for the Study of Liver Diseases

    2009.1

  18. Surgical Infection Society

    2009.4

  19. The Japan Society of Hepatology

    2011.1

  20. International Association of Pancreatology (IAP)

    2012.1

  21. Asian Pacific Hepato-Pancreto-Biliary Association (A-PHPBA)

    2012.1

  22. 日本外科代謝栄養学会

    2013.1

  23. 日本経腸静脈栄養学会

    2013.1

  24. International Association of Surgeons, Gastroenterologists and Oncologists

    2014.1

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Awards 4

  1. Best Oral Award

    2014.3   11th World Congress of International Hepato-Pancreato-Biliary Association  

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    Country:Korea, Republic of

  2. Travel Grant Award (Twenty-Fifth Annual Conference on Shock)

    2002   Twenty-Fifth Annual Conference on Shock  

  3. Stone Fellowship Award (University of North Carolina at Charlotte)

    2000   University of North Carolina at Charlotte  

  4. Scholarship for Young Researcher (Japan-North America Medical Exchange Foundation)

    1998.3   Japan-North America Medical Exchange Foundation  

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    Country:Japan

 

Papers 291

  1. A Study on Radial Margin Status in Resected Perihilar Cholangiocarcinoma Reviewed

    Shinohara Kentaro, Ebata Tomoki, Shimoyama Yoshie, Mizuno Takashi, Yokoyama Yukihiro, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Nagino Masato

    ANNALS OF SURGERY   Vol. 273 ( 3 ) page: 572 - 578   2021.3

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/SLA.0000000000003305

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  2. Impact of the preoperative body composition indexes on intraoperative blood loss in patients undergoing pancreatoduodenectomy Reviewed

    Ishii Kenta, Yokoyama Yukihiro, Ebata Tomoki, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Nagino Masato

    SURGERY TODAY   Vol. 51 ( 1 ) page: 52 - 60   2021.1

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00595-020-02054-y

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  3. Impact of Perioperative Steroid Administration in Patients Undergoing Major Hepatectomy with Extrahepatic Bile Duct Resection: A Randomized Controlled Trial Reviewed

    Onoe Shunsuke, Yokoyama Yukihiro, Ebata Tomoki, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Watanabe Nobuyuki, Suzuki Shogo, Nishiwaki Kimitoshi, Ando Masahiko, Nagino Masato

    ANNALS OF SURGICAL ONCOLOGY   Vol. 28 ( 1 ) page: 121 - 130   2021.1

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-020-08745-7

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  4. New method for the assessment of perineural invasion from perihilar cholangiocarcinoma Reviewed

    Tanaka Hiroshi, Igami Tsuyoshi, Shimoyama Yoshie, Ebata Tomoki, Yokoyama Yukihiro, Mori Kensaku, Nagino Masato

    SURGERY TODAY   Vol. 51 ( 1 ) page: 136 - 143   2021.1

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00595-020-02071-x

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  5. The survival benefit of neoadjuvant chemotherapy for resectable colorectal liver metastases with high tumor burden score Reviewed

    Yonekawa Yoshihiko, Uehara Kay, Mizuno Takashi, Aiba Toshisada, Ogura Atsushi, Mukai Toshiki, Yokoyama Yukihiro, Ebata Tomoki, Kodera Yasuhiro, Nagino Masato

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 26 ( 1 ) page: 126 - 134   2021.1

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10147-020-01793-9

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  6. ASO Author Reflections: Is Perioperative Steroids Administration Beneficial for Patients Undergoing Major Hepatectomy with Extrahepatic Bile Duct Resection? Reviewed

    Onoe Shunsuke, Yokoyama Yukihiro, Ebata Tomoki, Nagino Masato

    ANNALS OF SURGICAL ONCOLOGY   Vol. 27   page: 808 - 809   2020.12

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-020-08804-z

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  7. Characteristics of primary and repeated recurrent retroperitoneal liposarcoma: outcomes after aggressive surgeries at a single institution Reviewed

    Ishii Kenta, Yokoyama Yukihiro, Nishida Yoshihiro, Koike Hiroshi, Yamada Suguru, Kodera Yasuhiro, Sassa Naoto, Gotoh Momokazu, Nagino Masato

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 50 ( 12 ) page: 1412 - 1418   2020.12

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jjco/hyaa126

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  8. ASO Author Reflections: Real Prevalence of Microorganisms in Bile in Patients Undergoing Pancreatoduodenectomy Reviewed

    Suenaga Masaya, Yokoyama Yukihiro, Fujii Tsutomu

    ANNALS OF SURGICAL ONCOLOGY   Vol. 27   page: 761 - 762   2020.12

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-020-08662-9

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  9. Study of the Portal Branches Arising from the Cranial Part of the Umbilical Portion of the Left Portal Vein: Implications for Anatomic Right Hepatic Trisectionectomy Reviewed

    Minami Takayuki, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Nagino Masato

    WORLD JOURNAL OF SURGERY   Vol. 44 ( 12 ) page: 4231 - 4235   2020.12

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00268-020-05753-2

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  10. The influence of the preoperative thickness of the abdominal cavity on the gastrojejunal anatomic position and delayed gastric emptying after pancreatoduodenectomy Reviewed

    Watanabe Nobuyuki, Yokoyama Yukihiro, Ebata Tomoki, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Nagino Masato

    HPB   Vol. 22 ( 12 ) page: 1695 - 1702   2020.12

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.hpb.2020.03.016

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  11. How long should follow-up be continued after R0 resection of perihilar cholangiocarcinoma? Reviewed

    Nakahashi Koichi, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Nagino Masato

    SURGERY   Vol. 168 ( 4 ) page: 617 - 624   2020.10

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.surg.2020.04.068

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  12. Trefoil Factor Family 1 Inhibits the Development of Hepatocellular Carcinoma by Regulating beta-Catenin Activation Reviewed

    Ochiai Yosuke, Yamaguchi Junpei, Kokuryo Toshio, Yokoyama Yukihiro, Ebata Tomoki, Nagino Masato

    HEPATOLOGY   Vol. 72 ( 2 ) page: 503 - 517   2020.8

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/hep.31039

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  13. Tumor marker recovery rather than major pathological response is a preferable prognostic factor in patients with pancreatic ductal adenocarcinoma with preoperative therapy Reviewed

    Yamada Suguru, Yokoyama Yukihiro, Sonohara Fuminori, Yamaguchi Junpei, Takami Hideki, Hayashi Masamichi, Onoe Shunsuke, Fujii Tsutomu, Nagino Masato, Kodera Yasuhiro

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 27 ( 8 ) page: 487 - 495   2020.8

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jhbp.748

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  14. Application of fluorescent cholangiography during single-incision laparoscopic cholecystectomy in the cystohepatic duct without preoperative diagnosis Reviewed

    Asai Yuichi, Igami Tsuyoshi, Ebata Tomoki, Yokoyama Yukihiro, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Nagino Masato

    ANZ JOURNAL OF SURGERY     2020.7

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ans.16162

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  15. Postoperative infectious complications caused by multidrug-resistant pathogens in patients undergoing major hepatectomy with extrahepatic bile duct resection Reviewed

    Sugawara Gen, Yokoyama Yukihiro, Ebata Tomoki, Igami Tsuyoshi, Yamaguchi Junpei, Mizuno Takashi, Onoe Shunsuke, Watanabe Nobuyuki, Nagino Masato

    SURGERY   Vol. 167 ( 6 ) page: 950 - 956   2020.6

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.surg.2020.02.015

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  16. A case of retroperitoneal dedifferentiated liposarcoma successfully treated by neoadjuvant chemotherapy and subsequent surgery Reviewed

    Yokoyama Yukihiro, Nishida Yoshihiro, Ikuta Kunihiro, Nagino Masato

    SURGICAL CASE REPORTS   Vol. 6 ( 1 )   2020.5

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40792-020-00865-2

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  17. ASO Author Reflections: Please Walk at Least 5000 Steps per Day before Major Hepato-Pancreato-Biliary (HPB) Surgeries for Malignancy Reviewed

    Yokoyama Yukihiro, Nakajima Hiroki, Nagino Masato

    ANNALS OF SURGICAL ONCOLOGY   Vol. 27 ( 5 ) page: 1398 - 1399   2020.5

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-020-08294-z

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  18. How Many Steps Per Day are Necessary to Prevent Postoperative Complications Following Hepato-Pancreato-Biliary Surgeries for Malignancy? Reviewed

    Nakajima Hiroki, Yokoyama Yukihiro, Inoue Takayuki, Nagaya Motoki, Mizuno Yota, Kayamoto Azusa, Nishida Yoshihiro, Nagino Masato

    ANNALS OF SURGICAL ONCOLOGY   Vol. 27 ( 5 ) page: 1387 - 1397   2020.5

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-020-08218-x

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  19. Clinical characteristics and surgical outcomes of retroperitoneal tumors: a comprehensive data collection from multiple departments Reviewed

    Sassa Naoto, Yokoyama Yukihiro, Nishida Yoshihiro, Yamada Suguru, Uchida Hiroo, Kajiyama Hiroaki, Nagino Masato, Kodera Yasuhiro, Gotoh Momokazu

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 5 ) page: 929 - 936   2020.5

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10147-020-01620-1

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  20. Predictive performance of Blumgart T staging for perihilar cholangiocarcinoma in a Japanese center Reviewed

    Ebata Tomoki, Mizuno Takashi, Yokoyama Yukihiro, Igami Tsuyoshi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Nagino Masato

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 27 ( 3 ) page: 132 - 140   2020.3

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jhbp.694

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  21. Study on the Segmentation of the Right Posterior Sector of the Liver Reviewed

    Minami Takayuki, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Nagino Masato

    WORLD JOURNAL OF SURGERY   Vol. 44 ( 3 ) page: 896 - 901   2020.3

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00268-019-05238-x

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  22. In Situ Local pH Measurements with Hydrated Iridium Oxide Ring Electrodes in Neutral pH Aqueous Solutions Reviewed

    Yokoyama Yuko, Miyazaki Kohei, Kondo Yasuyuki, Miyahara Yuto, Fukutsuka Tomokazu, Abe Takeshi

    CHEMISTRY LETTERS   Vol. 49 ( 2 ) page: 195 - 198   2020.2

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1246/cl.190856

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  23. Negative Thermal Expansion of beta-Cu1.8Zn0.2V2O7 Ceramic Fine Particles Synthesized by a Spray-Drying Method Reviewed

    Takenaka Koshi, Sato Miku, Nishikawa Tomohiro, Omura Takuya, Yamada Nobuya, Yokoyama Yasunori, Katayama Naoyuki, Okamoto Yoshihiko

    JOURNAL OF THE JAPAN INSTITUTE OF METALS AND MATERIALS   Vol. 84 ( 5 ) page: 161 - 166   2020

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2320/jinstmet.J2019053

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  24. Tranexamic ACid during PancereaticoDuodenectomy (TAC-PD): study protocol for a multicentre randomised, blind, placebo-controlled trial Reviewed

    Ishii Kenta, Yokoyama Yukihiro, Yonekawa Yoshihiko, Ebata Tomoki

    BMJ OPEN   Vol. 10 ( 11 )   2020

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/bmjopen-2020-040914

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  25. A case of small in situ perihilar cholangiocarcinoma incidentally accompanied by benign bile duct stricture after open cholecystectomy Reviewed

    Maeda Takashi, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Nagino Masato

    SURGICAL CASE REPORTS   Vol. 5 ( 1 )   2019.12

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40792-019-0745-z

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  26. Postoperative Pancreatic Fistula in Surgery for Perihilar Cholangiocarcinoma Reviewed

    Watanabe Nobuyuki, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Nagino Masato

    WORLD JOURNAL OF SURGERY   Vol. 43 ( 12 ) page: 3094 - 3100   2019.12

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00268-019-05127-3

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  27. Benign hilar bile duct strictures resected as perihilar cholangiocarcinoma Reviewed

    Otsuka S., Ebata T., Yokoyama Y., Igami T., Mizuno T., Yamaguchi J., Onoe S., Watanabe N., Shimoyama Y., Nagino M.

    BRITISH JOURNAL OF SURGERY   Vol. 106 ( 11 ) page: 1504 - 1510   2019.10

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/bjs.11257

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  28. Discrepancy between volume and functional recovery in early phase liver regeneration following extended hepatectomy with extrahepatic bile duct resection Reviewed

    Maeda Takashi, Yokoyama Yukihiro, Ebata Tomoki, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Ando Masahiko, Nagino Masato

    HEPATOLOGY RESEARCH   Vol. 49 ( 10 ) page: 1227 - 1235   2019.10

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/hepr.13378

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  29. TREFOIL FACTOR FAMILY 1 INHIBITS THE DEVELOPMENT OF HEPATOCELLULAR CARCINOMA BY REGULATING B-CATENIN ACTIVATION Reviewed

    Ochiai Yosuke, Yamaguchi Junpei, Kokuryo Toshio, Yokoyama Yukihiro, Ebata Tomoki, Nagino Masato

    HEPATOLOGY   Vol. 70   page: 1196A - 1196A   2019.10

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    Publishing type:Research paper (scientific journal)  

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  30. Cholangiographic Tumor Classification for Simple Patient Selection Prior to Hepatopancreatoduodenectomy for Cholangiocarcinoma Reviewed

    Toyoda Yoshitaka, Ebata Tomoki, Mizuno Takashi, Yokoyama Yukihiro, Igami Tsuyoshi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Nagino Masato

    ANNALS OF SURGICAL ONCOLOGY   Vol. 26 ( 9 ) page: 2971 - 2979   2019.9

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-019-07457-x

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  31. Occult synchronous liver metastasis from perihilar cholangiocarcinoma Reviewed

    Ohiwa Takashi, Ebata Tomoki, Mizuno Takashi, Yokoyama Yukihiro, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Nagino Masato

    SURGERY   Vol. 166 ( 3 ) page: 290 - 296   2019.9

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.surg.2019.04.029

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  32. Preoperative course of patients undergoing endoscopic nasobiliary drainage during the management of resectable perihilar cholangiocarcinoma Reviewed

    Maeda Takashi, Ebata Tomoki, Yokoyama Yukihiro, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Kawashima Hiroki, Nagino Masato

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 26 ( 8 ) page: 341 - 347   2019.8

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jhbp.640

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  33. Left trisectionectomy combined with resection of the right hepatic vein and inferior vena cava after right hepatic vein embolization for advanced intrahepatic cholangiocarcinoma Reviewed

    Suzuki Toshihiro, Ebata Tomoki, Yokoyama Yukihiro, Mizuno Takashi, Igami Tsuyoshi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Nagino Masato

    SURGICAL CASE REPORTS   Vol. 5   2019.6

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40792-019-0655-0

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  34. Is constant negative pressure for external drainage of the main pancreatic duct useful in preventing pancreatic fistula following pancreatoduodenectomy? Reviewed

    Sunagawa Masaki, Yokoyama Yukihiro, Yamaguchi Junpei, Ebata Tomoki, Sugawara Gen, Igami Tsuyoshi, Mizuno Takashi, Nagino Masato

    PANCREATOLOGY   Vol. 19 ( 4 ) page: 602 - 607   2019.6

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.pan.2019.04.002

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  35. Clinical value of additional resection of a margin-positive distal bile duct in perihilar cholangiocarcinoma Reviewed

    Otsuka S., Ebata T., Yokoyama Y., Mizuno T., Tsukahara T., Shimoyama Y., Ando M., Nagino M.

    BRITISH JOURNAL OF SURGERY   Vol. 106 ( 6 ) page: 774 - 782   2019.5

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/bjs.11125

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  36. NEK2 Is an Effective Target for Cancer Therapy With Potential to Induce Regression of Multiple Human Malignancies Reviewed

    Kokuryo Toshio, Yokoyama Yukihiro, Yamaguchi Junpei, Tsunoda Nobuyuki, Ebata Tomoki, Nagino Masato

    ANTICANCER RESEARCH   Vol. 39 ( 5 ) page: 2251 - 2258   2019.5

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.13341

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  37. Pleural dissemination of cholangiocarcinoma caused by percutaneous transhepatic biliary drainage during the management of resectable cholangiocarcinoma Reviewed

    Yamashita Hiromasa, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Onoe Shunsuke, Watanabe Nobuyuki, Ando Masahiko, Nagino Masato

    SURGERY   Vol. 165 ( 5 ) page: 912 - 917   2019.5

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.surg.2018.10.015

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  38. Major hepatectomy with or without pancreatoduodenectomy for advanced gallbladder cancer Reviewed

    Mizuno T., Ebata T., Yokoyama Y., Igami T., Yamaguchi J., Onoe S., Watanabe N., Ando M., Nagino M.

    BRITISH JOURNAL OF SURGERY   Vol. 106 ( 5 ) page: 626 - 635   2019.4

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/bjs.11088

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  39. ASO Author Reflections: Is It Important to Do Exercise Before Surgery for HPB Malignancy? Reviewed

    Yokoyama Yukihiro

    ANNALS OF SURGICAL ONCOLOGY   Vol. 26 ( 1 ) page: 273 - 274   2019.1

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-018-7080-7

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  40. Clinical Benefit of Preoperative Exercise and Nutritional Therapy for Patients Undergoing Hepato-Pancreato-Biliary Surgeries for Malignancy Reviewed

    Nakajima Hiroki, Yokoyama Yukihiro, Inoue Takayuki, Nagaya Motoki, Mizuno Yota, Kadono Izumi, Nishiwaki Kimitoshi, Nishida Yoshihiro, Nagino Masato

    ANNALS OF SURGICAL ONCOLOGY   Vol. 26 ( 1 ) page: 264 - 272   2019.1

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    DOI: 10.1245/s10434-018-6943-2

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  41. Anti-tumor Effects of Deep Ultraviolet Irradiation for Pancreas Cancer Reviewed

    Yamazaki K., Kokuryo T., Yamaguchi J., Yokoyama Y., Nagino M.

    PANCREAS   Vol. 48 ( 10 ) page: 1553 - 1553   2019

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  42. Pharmacokinetics of Nek2 siRNA in Peritoneal Dissemination of Pancreatic Cancer Reviewed

    Kokuryo T., Yamaguchi J., Yokoyama Y., Nagino M.

    PANCREAS   Vol. 48 ( 10 ) page: 1465 - 1465   2019

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  43. Trefoil Factor Family 1 (TFF1) Inhibits Epithelial-mesenchymal Transition and Enhances the Chemosensitivity of Pancreatic Ductal Adenocarcinoma (PDAC) Reviewed

    Yamaguchi J., Kokuryo T., Yokoyama Y., Ebata T., Nagino M.

    PANCREAS   Vol. 48 ( 10 ) page: 1551 - 1552   2019

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  44. Comparison between autologous and homologous blood transfusions in liver resection for biliary tract cancer: a propensity score matching analysis Reviewed

    Onoe Shunsuke, Yokoyama Yukihiro, Ebata Tomoki, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Watanabe Nobuyuki, Nagino Masato

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 25 ( 12 ) page: 550 - 559   2018.12

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    DOI: 10.1002/jhbp.592

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  45. Loss of trefoil factor 1 inhibits biliary regeneration but accelerates the hepatic differentiation of progenitor cells in mice Reviewed

    Hayashi Yuki, Yamaguchi Junpei, Kokuryo Toshio, Ebata Tomoki, Yokoyama Yukihiro, Nagino Masato

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 506 ( 1 ) page: 12 - 19   2018.11

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    DOI: 10.1016/j.bbrc.2018.10.023

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  46. Surgery for perihilar cholangiocarcinoma from a viewpoint of age: Is it beneficial to octogenarians in an aging society? Reviewed

    Akashi Kumiko, Ebata Tomoki, Mizuno Takashi, Yokoyama Yukihiro, Igami Tsuyoshi, Yamaguchi Junpei, Onoe Shunsuke, Nagino Masato

    SURGERY   Vol. 164 ( 5 ) page: 1023 - 1029   2018.11

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    DOI: 10.1016/j.surg.2018.05.051

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  47. Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors Reviewed

    Ida Hideomi, Akiyama Tomohiko, Ishiguro Keiichiro, Goparaju Sravan K., Nakatake Yuhki, Chikazawa-Nohtomi Nana, Sato Saeko, Kimura Hiromi, Yokoyama Yukihiro, Nagino Masato, Ko Minoru S. H., Ko Shigeru B. H.

    STEM CELL RESEARCH & THERAPY   Vol. 9   2018.10

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    DOI: 10.1186/s13287-018-1038-3

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  48. Application of three-dimensional print in minor hepatectomy following liver partition between anterior and posterior sectors. Reviewed

    Igami T, Nakamura Y, Oda M, Tanaka H, Nojiri M, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Yamaguchi J, Mori K, Nagino M

    ANZ journal of surgery   Vol. 88 ( 9 ) page: 882 - 885   2018.9

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    DOI: 10.1111/ans.14331

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  49. Exploration of serum biomarkers for predicting the response to Inchinkoto (ICKT), a Japanese traditional herbal medicine (vol 13, 155, 2017) Reviewed

    Uji Masahito, Yokoyama Yukihiro, Ohbuchi Katsuya, Tsuchiya Kazuaki, Sadakane Chiharu, Shimobori Chika, Yamamoto Masahiro, Nagino Masato

    METABOLOMICS   Vol. 14 ( 9 )   2018.9

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    DOI: 10.1007/s11306-018-1407-z

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  50. Trefoil factor 1 inhibits epithelial-mesenchymal transition of pancreatic intraepithelial neoplasm Reviewed

    Yamaguchi Junpei, Yokoyama Yukihiro, Kokuryo Toshio, Ebata Tomoki, Enomoto Atsushi, Nagino Masato

    JOURNAL OF CLINICAL INVESTIGATION   Vol. 128 ( 8 ) page: 3619 - 3629   2018.8

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    DOI: 10.1172/JCI97755

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  51. Ethanol ablation for refractory bile leakage after complex hepatectomy Reviewed

    Ito A., Ebata T., Yokoyama Y., Igami T., Mizuno T., Yamaguchi J., Onoe S., Nagino M.

    BRITISH JOURNAL OF SURGERY   Vol. 105 ( 8 ) page: 1036 - 1043   2018.7

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/bjs.10801

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  52. Surgical resection for Bismuth type IV perihilar cholangiocarcinoma Reviewed

    Ebata T., Mizuno T., Yokoyama Y., Igami T., Sugawara G., Nagino M.

    BRITISH JOURNAL OF SURGERY   Vol. 105 ( 7 ) page: 829 - 838   2018.6

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/bjs.10556

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  53. Impact of the gastrojejunal anatomic position as the mechanism of delayed gastric emptying after pancreatoduodenectomy. Reviewed

    Nojiri M, Yokoyama Y, Maeda T, Ebata T, Igami T, Sugawara G, Yamaguchi J, Nagino M

    Surgery   Vol. 163 ( 5 ) page: 1063 - 1070   2018.5

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    DOI: 10.1016/j.surg.2017.11.016

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  54. Preoperative biliary colonization/infection caused by multidrug-resistant (MDR) pathogens in patients undergoing major hepatectomy with extrahepatic bile duct resection. Reviewed

    Sugawara G, Yokoyama Y, Ebata T, Igami T, Yamaguchi J, Mizuno T, Yagi T, Nagino M

    Surgery   Vol. 163 ( 5 ) page: 1106 - 1113   2018.5

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    DOI: 10.1016/j.surg.2017.12.031

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  55. Phase I study of chemoradiotherapy using gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic cancer Reviewed

    Yamada Suguru, Fujii Tsutomu, Yokoyama Yukihiro, Kawashima Hiroki, Maeda Osamu, Suzuki Kojiro, Okada Tohru, Ono Eizaburo, Yamaguchi Junpei, Takano Nao, Takami Hideki, Hayashi Masamichi, Niwa Yukiko, Hirooka Yoshiki, Ito Yoshiyuki, Naganawa Shinji, Ando Yuichi, Nagino Masato, Goto Hidemi, Kodera Yasuhiro

    CANCER CHEMOTHERAPY AND PHARMACOLOGY   Vol. 81 ( 5 ) page: 815 - 821   2018.5

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    DOI: 10.1007/s00280-018-3554-3

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  56. Recurrence after curative-intent resection of perihilar cholangiocarcinoma: analysis of a large cohort with a close postoperative follow-up approach. Reviewed

    Komaya K, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

    Surgery   Vol. 163 ( 4 ) page: 732 - 738   2018.4

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    DOI: 10.1016/j.surg.2017.08.011

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  57. Pre-exposure to Fluorouracil Increased Trifluridine Incorporation and Enhanced its Anti-tumor Effect for Colorectal Cancer Reviewed

    Baba Taisuke, Kokuryo Toshio, Yamaguchi Junpei, Yokoyama Yukihiro, Uehara Keisuke, Ebata Tomoki, Nagino Masato

    ANTICANCER RESEARCH   Vol. 38 ( 3 ) page: 1427 - 1434   2018.3

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    DOI: 10.21873/anticanres.12367

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  58. Inhibition of Toll-like receptor 4 ameliorates experimental postischemic injury in the cholestatic liver through inhibition of high-mobility group box protein b1 (HMGB1) signaling Reviewed

    Yokoi Tsuyoshi, Yokoyama Yukihiro, Kokuryo Toshio, Yamaguchi Junpei, Nagino Masato

    SURGERY   Vol. 163 ( 2 ) page: 270 - 276   2018.2

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    DOI: 10.1016/j.surg.2017.08.025

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  59. Does the intestinal microenvironment have an impact on the choleretic effect of inchinkoto, a hepatoprotective herbal medicine?

    Uji Masahito, Yokoyama Yukihiro, Asahara Takashi, Ebata Tomoki, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Nagino Masato

    HEPATOLOGY RESEARCH   Vol. 48 ( 3 ) page: E303-E310   2018.2

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    DOI: 10.1111/hepr.12985

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  60. Cells of origin of pancreatic neoplasms Reviewed

    Yamaguchi Junpei, Yokoyama Yukihiro, Kokuryo Toshio, Ebata Tomoki, Nagino Masato

    SURGERY TODAY   Vol. 48 ( 1 ) page: 9 - 17   2018.1

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    DOI: 10.1007/s00595-017-1501-2

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  61. Duration of Antimicrobial Prophylaxis in Patients Undergoing Major Hepatectomy With Extrahepatic Bile Duct Resection: A Randomized Controlled Trial Reviewed

    Sugawara Gen, Yokoyama Yukihiro, Ebata Tomoki, Mizuno Takashi, Yagi Tetsuya, Ando Masahiko, Nagino Masato

    ANNALS OF SURGERY   Vol. 267 ( 1 ) page: 142 - 148   2018.1

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    DOI: 10.1097/SLA.0000000000002049

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  62. Application of fluorescent cholangiography during single-incision laparoscopic cholecystectomy for cholecystitis with a right-sided round ligament: Preliminary experience Reviewed

    Nojiri Motoi, Igami Tsuyoshi, Toyoda Yoshitaka, Ebata Tomoki, Yokoyama Yukihiro, Sugawara Gen, Mizuno Takashi, Yamaguchi Junpei, Nagino Masato

    JOURNAL OF MINIMAL ACCESS SURGERY   Vol. 14 ( 3 ) page: 244 - 246   2018

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    DOI: 10.4103/jmas.JMAS_159_17

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  63. Single-Incision Laparoscopic Splenectomy for an Unruptured Aneurysm of the Splenic Artery Reviewed

    Toyoda Yoshitaka, Igami Tsuyoshi, Ochiai Yosuke, Ebata Tomoki, Yokoyama Yukihiro, Sugawara Gen, Mizuno Takashi, Yamaguchi Junpei, Nagino Masato

    MEDICAL PRINCIPLES AND PRACTICE   Vol. 27 ( 1 ) page: 95 - 98   2018

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    DOI: 10.1159/000485836

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  64. Prospective evaluation of the International Study Group for Liver Surgery definition of post hepatectomy liver failure after liver resection: an international multicentre study.

    HPB : the official journal of the International Hepato Pancreato Biliary Association     2017.12

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    DOI: 10.1016/j.hpb.2017.11.007

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  65. Application of fluorescent cholangiography during single-incision laparoscopic cholecystectomy for cholecystitis with a right-sided round ligament: Preliminary experience.

    Nojiri M, Igami T, Toyoda Y, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

    Journal of minimal access surgery     page: .   2017.12

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  66. Uneven acute non-alcoholic fatty change of the liver after percutaneous transhepatic portal vein embolization in a patient with hilar cholangiocarcinoma - a case report Reviewed

    Tsai Chun-Yi, Nojiri Motoi, Yokoyama Yukihiro, Ebata Tomoki, Mizuno Takashi, Nagino Masato

    BMC GASTROENTEROLOGY   Vol. 17 ( 1 ) page: 144   2017.12

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    DOI: 10.1186/s12876-017-0715-5

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  67. Successful local treatment for repeated hepatic recurrences of cholangiolocellular carcinoma: a report on a long-term survivor

    Shinohara Kentaro, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Sugawara Gen, Mizuno Takashi, Yamaguchi Junpei, Shimoyama Yoshie, Shiina Shuichiro, Tateishi Ryosuke, Arano Toru, Nagino Masato

    SURGICAL CASE REPORTS   Vol. 3 ( 1 ) page: 120   2017.12

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    DOI: 10.1186/s40792-017-0391-2

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  68. Exploration of serum biomarkers for predicting the response to Inchinkoto (ICKT), a Japanese traditional herbal medicine

    Uji Masahito, Yokoyama Yukihiro, Ohbuchi Katsuya, Tsuchiya Kazuaki, Sadakane Chiharu, Shimobori Chika, Yamamoto Masahiro, Nagino Masato

    METABOLOMICS   Vol. 13 ( 12 )   2017.12

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    DOI: 10.1007/s11306-017-1292-x

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  69. Usefulness of endoscopic ultrasonography-elastography as a predictive tool for the occurrence of pancreatic fistula after pancreatoduodenectomy Reviewed

    Kuwahara Takamichi, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Yokoyama Yukihiro, Fujii Tsutomu, Nakamura Shigeo, Kodera Yasuhiro, Nagino Masato, Goto Hidemi

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   Vol. 24 ( 12 ) page: 649 - 656   2017.12

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    DOI: 10.1002/jhbp.514

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  70. Successful Post-Transplant Psychiatric Interventions During Long-Term Follow-Up of Patients Receiving Liver Transplants for Alcoholic Liver Disease Reviewed

    Kimura Hiroyuki, Onishi Yasuharu, Kishi Shinichi, Kurata Nobuhiko, Ogiso Satoshi, Kamei Hideya, Tsuboi Chisato, Yamaguchi Naoko, Shiga Azusa, Kondo Mai, Yokoyama Yushun, Takasato Fumika

    AMERICAN JOURNAL OF CASE REPORTS   Vol. 18   page: 1215 - 1219   2017.11

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    DOI: 10.12659/AJCR.906446

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  71. Clinical influence of preoperative factor XIII activity in patients undergoing pancreatoduodenectomy Reviewed

    Watanabe Nobuyuki, Yokoyama Yukihiro, Ebata Tomoki, Sugawara Gen, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Nagino Masato

    HPB   Vol. 19 ( 11 ) page: 972 - 977   2017.11

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    DOI: 10.1016/j.hpb.2017.07.002

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  72. The Benefits of a Wound Protector in Preventing Incisional Surgical Site Infection in Elective Open Digestive Surgery: A Large-Scale Cohort Study

    Itatsu Keita, Yokoyama Yukihiro, Sugawara Gen, Kamiya Satoaki, Terasaki Masaki, Morioka Atsushi, Iyomasa Shinsuke, Shirai Kazuhisa, Ando Masahiko, Nagino Masato

    WORLD JOURNAL OF SURGERY   Vol. 41 ( 11 ) page: 2715-2722   2017.11

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    DOI: 10.1007/s00268-017-4082-8

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  73. Real-world experience with FOLFIRINOX and gemcitabine plus nab-paclitaxel in the treatment of pancreatic cancer in Japan Reviewed

    Maeda O., Yokoyama Y., Yamaguchi J., Ota A., Matsuoka A., Morita S., Inoue M., Mizutani T., Shimokata T., Urakawa H., Mitsuma A., Nagino M., Ando Y.

    ANNALS OF ONCOLOGY   Vol. 28   page: 69 - 69   2017.11

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  74. Loss of trefoil factor 1 inhibits biliary regeneration but accelerates the differentiation of hepatic progenitors into hepatocytes in mice

    Hayashi Yuki, Yamaguchi Junpei, Kokuryo Toshio, Ebata Tomoki, Yokoyama Yukihiro, Nagino Masato

    HEPATOLOGY   Vol. 66   page: 378A-379A   2017.10

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  75. The novel tumor suppressor Trefoil Factor Family 1 (TFF1) inhibits the development of hepatocellular carcinoma in mice

    Yamaguchi Junpei, Yokoyama Yukihiro, Kokuryo Toshio, Ebata Tomoki, Nagino Masato

    HEPATOLOGY   Vol. 66   page: 981A-982A   2017.10

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  76. Profile of preoperative fecal organic acids closely predicts the incidence of postoperative infectious complications after major hepatectomy with extrahepatic bile duct resection: Importance of fecal acetic acid plus butyric acid minus lactic acid gap

    Yokoyama Yukihiro, Mizuno Takashi, Sugawara Gen, Asahara Takashi, Nomoto Koji, Igami Tsuyoshi, Ebata Tomoki, Nagino Masato

    SURGERY   Vol. 162 ( 4 ) page: 926-934   2017.10

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    DOI: 10.1016/j.surg.2017.04.022

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  77. Inhibition of Toll-Like Receptor 4 Ameliorates Experimental Post-Ischemic Injury in the Cholestatic Liver through Inhibition of High-Mobility Group Box Protein B1 (HMGB1) Signaling Reviewed

    Yokoi Tsuyoshi, Yokoyama Yukihiro, Kokuryo Toshio, Yamaguchi Junpei, Nagino Masato

    HEPATOLOGY   Vol. 66   page: 153A - 153A   2017.10

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  78. Residual Carcinoma In Situ at the Ductal Stump has a Negative Survival Effect An Analysis of Early-stage Cholangiocarcinomas- - Reviewed

    Tsukahara Tetsuo, Ebata Tomoki, Shimoyama Yoshie, Yokoyama Yukihiro, Igami Tsuyoshi, Sugawara Gen, Mizuno Takashi, Nagino Masato

    ANNALS OF SURGERY   Vol. 266 ( 1 ) page: 126 - 132   2017.7

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    DOI: 10.1097/SLA.0000000000001944

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  79. Clinicopathologic study on metachronous double cholangiocarcinomas of perihilar and subsequent distal bile duct origin Reviewed

    Shinohara Kentaro, Shimoyama Yoshie, Ebata Tomoki, Yokoyama Yukihiro, Mizuno Takashi, Nakaguro Masato, Nagino Masato

    SURGERY   Vol. 162 ( 1 ) page: 84 - 93   2017.7

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    DOI: 10.1016/j.surg.2016.12.034

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  80. Long-term survival after multidisciplinary therapy for residual gallbladder cancer with peritoneal dissemination: a case report Reviewed

    Kuga Daisuke, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Sugawara Gen, Mizuno Takashi, Yamaguchi Junpei, Nagino Masato

    SURGICAL CASE REPORTS   Vol. 3 ( 1 ) page: 76   2017.6

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    DOI: 10.1186/s40792-017-0351-x

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  81. Novel therapy for pancreatic fistula using adipose-derived stem cell sheets treated with mannose Reviewed

    Kaneko Hirokazu, Kokuryo Toshio, Yokoyama Yukihiro, Yamaguchi Junpei, Yamamoto Tokunori, Shibata Rei, Gotoh Momokazu, Murohara Toyoaki, Ito Akira

    SURGERY   Vol. 161 ( 6 ) page: 1561 - 1569   2017.6

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    DOI: 10.1016/j.surg.2016.12.022

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  82. Feeding catheter gastrostomy with the round ligament of the liver prevents mechanical bowel obstruction after esophagectomy

    Kawai R., Abe T., Uemura N., Fukaya M., Saito T., Komori K., Yokoyama Y., Nagino M., Shinoda M., Shimizu Y.

    DISEASES OF THE ESOPHAGUS   Vol. 30 ( 6 )   2017.6

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    DOI: 10.1093/dote/dox009

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  83. Study on the segmentation of the right anterior sector of the liver Reviewed

    Kobayashi Tomoki, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Sugawara Gen, Mizuno Takashi, Yamaguchi Junpei, Nagino Masato

    SURGERY   Vol. 161 ( 6 ) page: 1536 - 1542   2017.6

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    DOI: 10.1016/j.surg.2016.12.020

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  84. Pulmonary Metastasis After Resection of Cholangiocarcinoma: Incidence, Resectability, and Survival Reviewed

    Yamada Mihoko, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Sugawara Gen, Mizuno Takashi, Yamaguchi Junpei, Nagino Masato

    WORLD JOURNAL OF SURGERY   Vol. 41 ( 6 ) page: 1550 - 1557   2017.6

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    DOI: 10.1007/s00268-017-3877-y

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  85. Gut microbiota and bacterial translocation in digestive surgery: the impact of probiotics

    Komatsu Shunichiro, Yokoyama Yukihiro, Nagino Masato

    LANGENBECKS ARCHIVES OF SURGERY   Vol. 402 ( 3 ) page: 401-416   2017.5

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    DOI: 10.1007/s00423-017-1577-6

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  86. Perineal alveolar soft part sarcoma treated by laparoscopy-assisted total pelvic exenteration combined with pubic resection Reviewed

    Aiba Toshisada, Uehara Keisuke, Tsukushi Satoshi, Yoshino Yasushi, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Sugawara Gen, Nagino Masato

    ASIAN JOURNAL OF ENDOSCOPIC SURGERY   Vol. 10 ( 2 ) page: 198 - 201   2017.5

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    DOI: 10.1111/ases.12342

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  87. The development of an automatically produced cholangiography procedure using the reconstructin of portal-phase multidetector-row computed tomography images: preliminary experience. Reviewed

    Hirose T, Igami T, Koga K, Hayashi Y, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Yamaguchi J, Mori K, Nagino M

    Surgery Today   Vol. 47 ( 3 ) page: 365-374   2017.3

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  88. The development of an automatically produced cholangiography procedure using the reconstruction of portal-phase multidetector-row computed tomography images: preliminary experience Reviewed

    Hirose Tomoaki, Igami Tsuyoshi, Koga Kusuto, Hayashi Yuichiro, Ebata Tomoki, Yokoyama Yukihiro, Sugawara Gen, Mizuno Takashi, Yamaguchi Junpei, Mori Kensaku, Nagino Masato

    SURGERY TODAY   Vol. 47 ( 3 ) page: 365 - 374   2017.3

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    DOI: 10.1007/s00595-016-1394-5

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  89. A clear difference between the outcomes after a major hepatectomy with and without an extrahepatic bile duct resection. Reviewed

    Takagi T, Yokoyama Y, Kokuryo T, Ebata T, Ando M, Nagino M.

    World Journal of Surgery   Vol. 41 ( 2 ) page: 508-515   2017.2

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  90. Adjuvant gemcitabine monotherapy for resectable perihilar cholangiocarcinoma with lymph node involvement: a propensity score matching analysis. Reviewed

    Mizuno T, Ebata T, Yokoyama Y, Igami T, Sugawara G, Yamaguchi J, Nagino M.

    Surgery Today   Vol. 47 ( 2 ) page: 182-192   2017.2

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  91. Preoperative six-minute walk distance accurately predicts postoperative complications following surgeries for hepato-pancreato-biliary cancer. Reviewed

    Hayashi K, Yokoyama Y, Nakajima H, Nagino M, Inoue T, Nagaya M, Hattori K, Kadono I, Ito S, Nishida Y.

    Surgery   Vol. 161 ( 2 ) page: 525-532   2017.2

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  92. Anatomical features of independent right posterior portal vein variants: implications for left hepatic trisectionectomy. Reviewed

    Watanabe N, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

    Surgery   Vol. 161 ( 2 ) page: 347-354   2017.2

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  93. Verification of the oncological inferiority of percutaneous biliary drainage to endoscopic drainage: A propensity score matching analysis of resectable perihilar cholangiocarcinoma. Reviewed

    Komaya K, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

    Surgery   Vol. 161 ( 2 ) page: 394-404   2017.2

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  94. The anti-cancer effect of novel alpha-bisabolol derivatives against pancreatic cancer. Reviewed

    185. Murata Y, Kokuryo T, Yokoyama Y, Yamaguchi J, Miwa T, Shibuya M, Yamamoto Y, Nagino M

    Anticancer Research   Vol. 37 ( 2 ) page: 589-598   2017.2

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  95. Surgery-related muscle loss and its association with postoperative complications after major hepatectomy with extrahepatic bile duct resection. Reviewed

    Otuji H, Yokoyama Y, Ebata T, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

    World Journal of Surgery   Vol. 41 ( 2 ) page: 498-507   2017.2

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  96. A Clear Difference Between the Outcomes After a Major Hepatectomy With and Without an Extrahepatic Bile Duct Resection Reviewed

    Takagi Takehiro, Yokoyama Yukihiro, Kokuryo Toshio, Ebata Tomoki, Ando Masahiko, Nagino Masato

    WORLD JOURNAL OF SURGERY   Vol. 41 ( 2 ) page: 508 - 515   2017.2

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    DOI: 10.1007/s00268-016-3744-2

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  97. Verification of the oncologic inferiority of percutaneous biliary drainage to endoscopic drainage: A propensity score matching analysis of resectable perihilar cholangiocarcinoma Reviewed

    Komaya Kenichi, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Sugawara Gen, Mizuno Takashi, Yamaguchi Junpei, Nagino Masato

    SURGERY   Vol. 161 ( 2 ) page: 394 - 404   2017.2

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    DOI: 10.1016/j.surg.2016.08.008

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  98. The Anticancer Effects of Novel alpha-Bisabolol Derivatives Against Pancreatic Cancer Reviewed

    Murata Yoshihiko, Kokuryo Toshio, Yokoyama Yukihiro, Yamaguchi Junpei, Miwa Tomohiro, Shibuya Masatoshi, Yamamoto Yoshihiko, Nagino Masato

    ANTICANCER RESEARCH   Vol. 37 ( 2 ) page: 589 - 598   2017.2

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    DOI: 10.21873/anticanres.11352

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  99. Surgery-Related Muscle Loss and Its Association with Postoperative Complications After Major Hepatectomy with Extrahepatic Bile Duct Resection Reviewed

    Otsuji Hidehiko, Yokoyama Yukihiro, Ebata Tomoki, Igami Tsuyoshi, Sugawara Gen, Mizuno Takashi, Yamaguchi Junpei, Nagino Masato

    WORLD JOURNAL OF SURGERY   Vol. 41 ( 2 ) page: 498 - 507   2017.2

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    DOI: 10.1007/s00268-016-3732-6

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  100. Preoperative 6-minute walk distance accurately predicts postoperative complications after operations for hepato-pancreato-biliary cancer Reviewed

    Hayashi Kazuhiro, Yokoyama Yukihiro, Nakajima Hiroki, Nagino Masato, Inoue Takayuki, Nagaya Motoki, Hattori Keiko, Kadono Izumi, Ito Satoru, Nishida Yoshihiro

    SURGERY   Vol. 161 ( 2 ) page: 525 - 532   2017.2

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    DOI: 10.1016/j.surg.2016.08.002

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  101. Anatomic features of independent right posterior portal vein variants: Implications for left hepatic trisectionectomy Reviewed

    Watanabe Nobuyuki, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Sugawara Gen, Mizuno Takashi, Yamaguchi Junpei, Nagino Masato

    SURGERY   Vol. 161 ( 2 ) page: 347 - 354   2017.2

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    DOI: 10.1016/j.surg.2016.08.024

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  102. Adjuvant gemcitabine monotherapy for resectable perihilar cholangiocarcinoma with lymph node involvement: a propensity score matching analysis Reviewed

    Mizuno Takashi, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Sugawara Gen, Yamaguchi Junpei, Nagino Masato

    SURGERY TODAY   Vol. 47 ( 2 ) page: 182 - 192   2017.2

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    DOI: 10.1007/s00595-016-1354-0

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  103. Occult mucin-producing cholangiocarcinoma in situ: a rare clinical case with difficult tumour staging Reviewed

    Kiriyama Muneyasu, Ebata Tomoki, Yokoyama Yukihiro, Igami Tsuyoshi, Sugawara Gen, Mizuno Takashi, Yamaguchi Junpei, Nagino Masato

    SURGICAL CASE REPORTS   Vol. 3 ( 1 ) page: 6   2017.1

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    DOI: 10.1186/s40792-016-0283-x

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  104. Benefit to perform indocyanine green clearance test; Reply to East or West, who grades liver failure after liver resection for perihilar cholangiocarcinoma best? Reviewed

    Yokoyama Y, Nagino M.

    World Journal of Surgery   Vol. 41 ( 1 ) page: 339-340   2017.1

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  105. Benefit to Perform Indocyanine Green Clearance Test: Reply Reviewed

    Yokoyama Yukihiro, Nagino Masato

    WORLD JOURNAL OF SURGERY   Vol. 41 ( 1 ) page: 339 - 340   2017.1

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    DOI: 10.1007/s00268-016-3696-6

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  106. Risk Factors for Postoperative Delirium in Abdominal Surgery: A Proposal of a Postoperative Delirium Risk Score in Abdominal Surgery

    Miyagawa Yasuhiro, Yokoyama Yukihiro, Fukuzawa Shota, Fukata Shinji, Ando Masahiko, Kawamura Takashi, Yamada Kiyofumi, Nagino Masato

    DIGESTIVE SURGERY   Vol. 34 ( 2 ) page: 95-102   2017

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    DOI: 10.1159/000449044

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  107. Trefoil factor family 1 expression in the invasion front is a poor prognostic factor associated with lymph node metastasis in pancreatic cancer Reviewed

    Sunagawa Masaki, Yamaguchi Junpei, Kokuryo Toshio, Ebata Tomoki, Yokoyama Yukihiro, Sugawara Gen, Nagino Masato

    PANCREATOLOGY   Vol. 17 ( 5 ) page: 782 - 787   2017

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    DOI: 10.1016/j.pan.2017.07.188

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  108. Effects of Synbiotics to Prevent Postoperative Infectious Complications in Highly Invasive Abdominal Surgery

    Yokoyama Yukihiro, Asahara Takashi, Nomoto Koji, Nagino Masato

    ANNALS OF NUTRITION AND METABOLISM   Vol. 71   page: 23-30   2017

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    DOI: 10.1159/000479920

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  109. Does Braun Anastomosis Have an Impact on the Incidence of Delayed Gastric Emptying and the Extent of Intragastric Bile Reflux Following Pancreatoduodenectomy? - A Randomized Controlled Study Reviewed

    Fujieda Hironori, Yokoyama Yukihiro, Hirata Akihiro, Usui Hiroaki, Sakatoku Yayoi, Fukaya Masahide, Nagino Masato

    DIGESTIVE SURGERY   Vol. 34 ( 6 ) page: 462 - 468   2017

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    DOI: 10.1159/000455334

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  110. Different Clinical Characteristics Between Distal Cholangiocarcinoma and Pancreatic Head Carcinoma With Biliary Obstruction Reviewed

    Yokoyama Yukihiro, Ebata Tomoki, Igami Tsuyoshi, Sugawara Gen, Mizuno Takashi, Yamaguchi Junpei, Nagino Masato

    PANCREAS   Vol. 46 ( 10 ) page: 1322 - 1326   2017

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    DOI: 10.1097/MPA.0000000000000942

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  111. The complete loss of tyrosine kinase receptors MET and RON is a poor prognostic factor in patients with extrahepatic cholangiocarcinoma. Reviewed

    Hayashi Y, Yamaguchi J, Kokuryo T, Ebata T, Yokoyama Y, Igami T, Sugawara G, Nagino M.

    Anticancer Research   Vol. 36 ( 12 ) page: 6585-6592   2016.12

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  112. The effects of bevacizumab on intestinal anastomoticc healing in rabbits. Reviewed

    Nakamura H, Yokoyama Y, Uehara K, Kokuryo T, Junpei Y, Tsuzuki T, Nagino M.

    Surgery Today   Vol. 46 ( 12 ) page: 1456-1463   2016.12

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  113. Clinical value and pitfalls of fluorescent choloangiography during single-incision laparoscopic cholecystectomy. Reviewed

    Igami T, Nojiri M, Shinohara K, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Yamaguchi J, Nagino M.

    Surgery Today   Vol. 46 ( 12 ) page: 1443-1450   2016.12

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  114. Application of fluorescent cholangiography for determination of the resection line during a single-incision laparoscopic cholecystectomy for a benign lesion of the cystic duct: preliminary experience. Reviewed

    Nojiri M, Igami T, Tanaka H, Toyoda Y, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Yamaguchi J, Nagino M

    Surg Laparosc Endosc Percutan Tech   Vol. 26 ( 6 ) page: e171-e173   2016.12

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  115. Occult mucin-producing cholangiocarcinoma in situ: a rare clinical case with difficult tumour staging. Reviewed

    Kiriyama M, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M.

    Surgical Case Reports   Vol. 3 ( 1 ) page: 6   2016.12

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  116. TRIP13 is expressed in colorectal cancer and promotes cancer cell invasion. Reviewed

    Kurita K, Maeda M, Mansour MA, Kokuryo T, Uehara K, Yokoyama Y, Nagino M, Hamaguchi M, Senga T

    Oncology Letters.   Vol. 12 ( 6 ) page: 5240-5246   2016.12

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  117. Appraisal of inflammation-based prognostic scores in patients with unresectable perihilar cholangiocarcinoma. Reviewed

    Okuno M, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M.

    J Hepatobiliary Pnacreatic Science   Vol. 23 ( 10 ) page: 636-642   2016.10

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  118. Nek2 siRNA therapy using aportal venous port-catheter system for liver metastasis in pancreatic cancer. Reviewed

    Kokuryo T, Hibino S, Suzuki K, Watanabe K, Yokoyama Y, Nagino M, Senga T, Hamaguchi M.

    Cancer Science   Vol. 107 ( 9 ) page: 1315-1320   2016.9

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  119. Risk factors for postoperative delirium in abdominal surgery: A proposal of a postoperative delirium risk score in abdominal surgery. Reviewed

    Miyagawa Y, Yokoyama Y, Fukuzawa S, Fukata S, Ando M, Kawamura T, Yamada K, Nagino M.

    Digestive Surgery   Vol. 34 ( 2 ) page: 95-102   2016.8

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  120. Laparoscopic repeat hepatectomy after right hepatopancreaticoduodenectomy. Reviewed

    Igami T, Komaya K, Hirose T, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Yamaguchi J, Nagino M.

    Asian Journal of Endoscopic Surgery   Vol. 9 ( 3 ) page: 211-214   2016.8

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  121. The predictive value of indocyanine green clearance in future liver remnant for posthepatectomy liver failure following hepatectomy with extrahepatic bile duct resection. Reviewed

    Yokoyama Y, Ebata T, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M.

    World Journal of Surgery   Vol. 40 ( 6 ) page: 1440-1447   2016.6

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  122. Prediction of early recurrence after the curative resection of colorectal liver metastasis and subsequent S-1 chemotherapy. Reviewed

    Yamauchi K, Kokuryo T, Yokoyama Y, Uehara K, Yamaguchi J, Nagino M.

    Anticancer Research   Vol. 36 ( 5 ) page: 2175-2179   2016.5

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  123. Retrocolic or antecolic Roux-en-Y reconstruction after distal gastrectomy: which is more effective in the prevention of postoperative gastroesophageal reflux disease? Reviewed

    Hirata A, Fukaya M, Yokoyama Y, Miyahara R, Funasaka K, Nagino M.

    Digestive Surgery   Vol. 33 ( 5 ) page: 371381   2016.4

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  124. Effect of perioperative synbiotic treatment on bacterial translocation and postoperative infectious complications after pancreatoduodenectomy. Reviewed

    Yokoyama Y, Miyake T, Kokuryo T, Asahara T, Nomoto K, Nagino M.

    Digestive Surgery   Vol. 33 ( 3 ) page: 220-229   2016.3

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  125. Cholangiocarcinoma with intraductal tubular growth pattern versus intraductal papillary growth pattern. Reviewed

    Tsukahara T, Shimoyama Y, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nakamura S, Nagino M

    Modern Pathology   Vol. 29 ( 3 ) page: 293-301   2016.3

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  126. Proposal for a pancreatic configuration index for determining patients at high risk of pancreatic fistula following pancreatoduodenectomy. Reviewed

    Yokoyama Y, Ebata T, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M.

    Digestive Surgery   Vol. 33 ( 3 ) page: 169-176   2016.2

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  127. α-Bisabolol inhibits invasiveness and motility in pancreatic cancer through KISS1R activation. Reviewed

    Uno M, Kokuryo T, Yokoyama Y, Senga T, Nagino M

    Anticancer Research   Vol. 36 ( 2 ) page: 583-589   2016.2

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  128. Verification of WFA-sialylated MUC1 as a sensitive biliary biomarker for human biliary tract cancer. Reviewed

    Yamaguchi T, Yokoyama Y, Ebata T, Matsuda A, Kuno A, Ikehara Y, Shoda J, Narimatsu H, Nagino M.

    Annals of Surgical Oncology   Vol. 23 ( 2 ) page: 671-677   2016.2

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  129. The value of preoperative screening colonoscopies in patients with biliary tract cancer. Reviewed

    Itatsu K, Yokoyama Y, Ebata T, Igami T, Sugawara G, Uehara K, Mizuno T, Ando M, Goto H, Nagino M.

    Journal of Gastroenterology   Vol. 51 ( 2 ) page: 138-143   2016.2

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  130. Evaluation of inflammation-based prognostic scores in patients undergoing hepatobiliary resection for perihilar cholangiocarcinoma. Reviewed

    Okuno M, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nagino M.

    Journal of Gastroenterology   Vol. 51 ( 2 ) page: 153-161   2016.2

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  131. Initial experience of laparoscopic pelvic exenteration and comparison with conventional open surgery. Reviewed

    Uehara K, Nakamura H, Yoshino Y, Arimoto A, Kato T, Yokoyama Y, Ebata T, Nagino M

    Surgical Endoscopy   Vol. 30 ( 1 ) page: 132-138   2016.1

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  132. Surgical and radiological studies on the length of the hepatic ducts. Reviewed

    Hirose T, Igami T, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Mori K, Ando M, Nagino M

    World Journal of Surgery   Vol. 39 ( 12 ) page: 2983-2985   2015.12

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  133. Liver regeneration following experimental major hepatectomy with choledocho-jejunostomy. Reviewed

    Takagi T, Yokoyama Y, Kokuryo T, Yamaguchi J, Nagino M.

    British Journal of Surgery   Vol. 102 ( 11 ) page: 1410-1417   2015.11

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  134. FOLFIRINOX-induced reversible dysarthria: A case report and review of previous cases. Reviewed

    Matsuoka A, Maeda O, Inada-Inoue M, Ohno E, Hirooka Y, Yokoyama Y, Fujii T, Nagino M, Goto H, Ando Y

    Oncology Letter   Vol. 10 ( 4 ) page: 2662-2664   2015.10

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  135. Percutaneous transhepatic portal vein stenting for malignant portal vein stenosis secondary to recurrent perihilar biliary cancer. Reviewed

    Mizuno T, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mori Y, Suzuki K, Nagino M

    J Hepatobiliary Pancreat Sci   Vol. 22 ( 10 ) page: 740-745   2015.10

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  136. . Long-term survival following extended hepatectomy with concomitant resectio of all major hepatic veins for intrahepatic cholangiocarcinoma: report of a case. Reviewed

    Kobayashi S, Igami T, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Nimura Y, Nagino M.

    Surgery Today   Vol. 45 ( 8 ) page: 1058-1063   2015.8

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  137. Combined extrahepatic bile duct resection for locally advanced gallbladder carcinoma: Does it work? Reviewed

    Igami T, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Yamaguchi J, Shimoyama Y, Nagino M.

    World Journal of Surgery   Vol. 39 ( 7 ) page: 1810-1817   2015.7

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  138. Therapeutic potential of targeting protein for Xklp2 (TPX2) silencing for pancreatic cancer. Reviewed

    Miwa T, Kokuryo T, Yokoyama Y, Yamaguchi J, Nagino M.

    Cancer Medicine   Vol. 4 ( 7 ) page: 1091-1100   2015.7

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  139. Prognostic value of hepatocyte growth factor receptor expression in patients with perihilar cholangiocarcinoma. Reviewed

    Watanabe H, Yokoyama Y, Kokuryo T, Ebata T, Igami T, Sugawara G, Mizuno T, Shimoyama Y, Nagino M.

    Annals of Surgical Oncology   Vol. 22 ( 7 ) page: 2235-2242   2015.7

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  140. Stent-graft treatment for extrahepatic portal vein hemorrhage after pancreaticoduodenectomy. Reviewed

    Suzuki K, Igami T, Komada T, Mori Y, Yokoyama Y, Ebata T, Naganawa S, Nagino M.

    Acta Radiologica Open   Vol. 4 ( 6 ) page: 1-4   2015.6

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  141. The intermittent Pringle maneuver is unlikely to induce bacterial translocation to the portal vein: a study using bacterium-specific ribosomal RNA-targeted RT-PCR. Reviewed

    Yamaguchi N, Yokoyama Y, Ebata T, Igami T, Sugawara G, Asahara T, Nomoto K, Nagino M.

    J Hepatobiliary Pancreat Sci.   Vol. 22 ( 6 ) page: 491-497   2015.6

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  142. Preoperative sarcopenia negatively impacts postoperative outcomes following major hepatectomy with extrahepatic bile duct resection. Reviewed

    Otsuji H, Yokoyama Y, Ebata T, Igami T, Sugawara G, Mizuno T, Nagino M.

    World Journal of Surgery   Vol. 39 ( 6 ) page: 1494-1500   2015.6

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  143. Application of a Z-shaped umbilical incision and asaline-cooled radiofrequency device to single-incision laparoscopic surgery for a huge liver cyst: report of a case. Reviewed

    Igami T, Tsuchiya T, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Nagino M.

    International Surgery   Vol. 100 ( 6 ) page: 1098-1103   2015.6

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  144. The impact of Girdin expression on recurence-free survival in patients with luminal-type breast cancer. Reviewed

    Nishimae K, Tsunoda N, Yokoyama Y, Kokuryo T, Iwakoshi A, Takahashi M, Nagino M.

    Breast Cancer   Vol. 22 ( 5 ) page: 445-451   2015.5

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  145. Single-incisin laparoscopic cholecystectomy after endoscopic nasogallbladder drainage: A case report. Reviewed

    Igami T, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Yamaguchi J, Nagino M.

    Med Princ Pract.   Vol. 24 ( 5 ) page: 496-499   2015.5

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  146. Does inchinkoto, a herbal medicine, have hepatoprotective effects in major hepatectomy? A prospective randomized study. Reviewed

    Mizutani T, Yokoyama Y, Kokuryo T, Ebata T, Igami T, Sugawara G, Nagino M.

    HPB (Oxford)   Vol. 17 ( 5 ) page: 461-469   2015.5

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  147. Clinicopathological significance of mucin production in patients with papillary cholangiocarcinoma. Reviewed

    Onoe S, Shimoyama Y, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Nakamura S, Nagino M.

      Vol. 39 ( 5 ) page: 1177-1184   2015.5

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  148. Assessment of percutaneous transhepatic portal vein embolization with portal vein stenting for perihilar cholangiocarcinoma with severe portal vein stenosis. Reviewed

    Hyodo R, Suzuki K, Ebata T, Komada T, Mori Y, Yokoyama Y, Igami T, Sugawara G, Naganawa S, Nagino M.

    J Hepatobiliary Pancreat Sci.   Vol. 22 ( 4 ) page: 310-315   2015.4

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  149. Single-incision laparoscopic cholecystectomy for cholecystitis requiring percutaneous transhepatic gallbladder drainage. Reviewed

    Igami T, Aoba T, Ebata T, Yokoyama Y, Sugawara G, Nagino M.

    Surgery Today   Vol. 45 ( 3 ) page: 305-309   2015.3

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  150. Prospective Evaluation of the International Study Group for Liver Surgery Definition of Bile Leak after Liver Resection and the Role of Routine Operative Drainage: An International Multicentre Study. Reviewed

    Brooke-Smith M, Figueras J, Ullah S, Rees M, Vauthey JN, Hugh TJ, Garden OJ, Fan ST, Crawford M, Makuuchi M, Yokoyama Y, Büchler M, Weitz J, Padbury R.

    HPB (Oxford)   Vol. 17 ( 1 ) page: 46-51   2015.1

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  151. Surgery for recurrent biliary tract cancer: A single-center experience with 74 consecutive resections. Reviewed

    Takahashi Y, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Nimura Y, Nagino M.

    Annals of Surgery   Vol. 262 ( 1 ) page: 121-129   2015.1

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  152. Application of a Z-shaped umbilical incision and asaline-cooled radiofrequency device to single-incision laparoscopic surgery for ha huge liver cyst: report of a case. Reviewed

    158. Igami T, Tsuchiya T, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Nagino M.

    International Surgery   Vol. 100 ( 6 ) page: 1098-1103   2015

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  153. The pathologic correlation between liver and portal vein invasion in perihilar cholangiocarcinoma: evaluating the oncologic rationale for the American Joint Committee on Cancer Definitions of T2 and T3 tumors. Reviewed

    Ito T, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Shimoyama Y, Nagino M.

    World Journal of Surgery   Vol. 38 ( 12 ) page: 3215-3221   2014.12

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  154. Hepatopancreatoduodenectomy with arterial reconstruction for extrahepatic cholangiocarcinoma with celiac axis obstruction: report of a case. Reviewed

    Nakagawa A, Sugawara G, Ebata T, Yokoyama Y, Igami T, Shingu Y, Nagino M.

    Surgery Today   Vol. 44 ( 12 ) page: 2374-2377   2014.12

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  155. Management strategy for biliary stricture following laparoscopic cholecystectomy. Reviewed

    Sugawara G, Ebata T, Yokoyama Y, Igami T, Mizuno T, Nagino M.

    J Hepatobiliary Pancreat Sci.   Vol. 21 ( 12 ) page: 889-895   2014.12

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  156. A study of the right intersectional plane (right portal scissura) of the liver based on virtual left hepatic trisectionectomy.

    Sato F, Igami T, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Nagino M.

    World Journal of Surgery   Vol. 38 ( 12 ) page: 3181-3185   2014.12

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  157. Application of a three-dimensional print of a liver in hepatectomy for small tumors invisible by intraoperative ultrasonography: preliminary experience. Reviewed

    Igami T, Nakamura Y, Hirose T, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Mori K, Nagino M.

    World Journal of Surgery   Vol. 38 ( 12 ) page: 3163-3166   2014.12

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  158. The adverse effects of preoperative cholangitis on the outcome of portal vein embolization and subsequent major hepatectomies. Reviewed

    Yokoyama Y, Ebata T, Igami T, Sugawara G, Mizuno T, Nagino M.

    Surgery   Vol. 156 ( 5 ) page: 1190-1196   2014.11

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  159. Incidence and risk factors for incisional hernia after abdominal surgery. Reviewed

    Itatsu K, Yokoyama Y, Sugawara G, Kubota H, Tojima Y, Kurumiya Y, Kono H, Yamamoto H, Ando M, Nagino M.

      Vol. 101 ( 11 ) page: 1439-1447   2014.11

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  160. Incidence of and risk factors for incisional hernia after abdominal surgery. Reviewed

    Itatsu K, Yokoyama Y, Sugawara G, Kuobota H, Tojima Y, Kurumiya Y, Kono H, Ymamoto H, Ando M, Nagino M

    British Journal of Surgery   Vol. 101 ( 11 ) page: 1439-1447   2014.10

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  161. Review of hepatopancreatoduodenectomy for biliary cancer: an extended radical approach of Japanese origin. Reviewed

    Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Nagino M.

    J Hepatobiliary Pancreat Sci.   Vol. 21 ( 8 ) page: 550-555   2014.8

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  162. Surgical technique of hepatectomy combined with simultaneous resection of hepatic artery and portal vein for perihilar cholangiocarcinoma (with video). Invited Reviewed

    Ebata T, Ito T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Nagino M.

    J Hepatobiliary Pancreat Sci.   Vol. 21 ( 8 ) page: E57-61   2014.8

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  163. Postoperative complications following neoadjuvant bevacizumab treatment for advanced colorectal cancer. Reviewed

    Yoshioka Y, Uehara K, Ebata T, Yokoyama Y, Mitsuma A, Ando Y, Nagion M.

    Surgery Today   Vol. 44 ( 7 ) page: 1300-1306   2014.7

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  164. Risk factors for incisional surgical site infections in elective surgery for colorectal cancer: focus on intraoperative meticulous wound management. Reviewed

    Itatsu K, Sugawara G, Kaneoka Y, Kato T, Takeuchi E, Kanai M, Hasegawa H, Arai T, Yokoyama Y, Nagino M.

    Surgery Today   Vol. 44 ( 7 ) page: 1242-1252   2014.7

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  165. Postoperative complications following neoadjuvant bevacizumab treatment for advanced colorectal cancer. Reviewed

    Yoshioka Y, Uehara K, Ebata T, Yokoyama Y, Mitsuma A, Ando Y, Nagion M.

      Vol. 44 ( 7 ) page: 1300-1306   2014.7

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  166. Risk factors for incisional surgical site infections in elective surgery for colorectal cancer: focus on intraoperative meticulous wound management. Reviewed

    Itatsu K, Sugawara G, Kaneoka Y, Kato T, Takeuchi E, Kanai M, Hasegawa H, Arai T, Yokoyama Y, Nagino M.

    Surgery Today   Vol. 44 ( 7 ) page: 1242-1252   2014.7

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  167. Randomized controlled trial on timing and number of sampling for bile aspiration cytology. Reviewed

    Tsuchiya T, Yokoyama Y, Ebata T, Igami T, Sugawara G, Kato K, Shimoyama Y, Nagino M.

    J Hepatobiliary Pancreat Sci.   Vol. 21 ( 6 ) page: 433-438   2014.6

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  168. Portal vein embolization using absolute ethanol: evaluation of its safety and efficacy. Reviewed

    Igami T, Ebata T, Yokoyama Y, Sugawara G, Takahashi Y, Nagino M.

    J Hepatobiliary Pancreat Sci.   Vol. 21 ( 9 ) page: 676-681   2014.5

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  169. Adenocarcinoma arising from sacrococcygeal mature teratoma in an adult female: report of a case. Reviewed

    Matsumoto N, Uehara K, Ando M, Arimoto J, Kato T, Nakamura H, Ebata T, Yokoyama Y, Nagino M

    Frontiers in Oncology   Vol. 4   page: 117   2014.5

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  170. Two-stage operation for synchronous triple primary cancer of the esophagus, stomach, and ampulla of Vater: report of a case. Reviewed

    Fukaya M, Abe T, Yokoyama Y, Itatsu K, Nagino M.

    Surgery Today   Vol. 44 ( 5 ) page: 967-971   2014.5

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  171. Hepatopancreatoduodenectomy for anastomotic recurrence from residual cholangiocarcinoma: report of a case. Reviewed

    Natsume S, Ebata T, Yokoyama Y, Igami T, Sugawara G, Takahashi Y, Nagino M.

    Surgery Today   Vol. 44 ( 5 ) page: 952-956   2014.5

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  172. Current scenario for the hepatoprotective effects of Inchinkoto (ICKT), a traditional herbal medicine, and its clinical application in liver surgery: A review. Reviewed

    Yokoyama Y, Nagino M.

      Vol. 44 ( 4 ) page: 384-394   2014.4

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  173. Predictive power of prothrombin time and serum total bilirubin for postoperative mortality after major hepatectomy with extrahepatic bile duct resection. Reviewed

    Yokoyama Y, Ebata T, Igami T, Sugawara G, Ando M, Nagino M.

    Surgery   Vol. 155 ( 2 ) page: 280-291   2014.3

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  174. The detection of intraoperative bacterial translocation in the mesenteric lymph nodes is useful in predicting patients at high risk for postoperative infectious complications after esophagectomy. Reviewed

    Nishigaki E, Abe T, Yokoyama Y, Fukaya M, Asahara T, Nomoto K, Nagino M.

    Annals of Surgery   Vol. 259 ( 3 ) page: 477-484   2014.3

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  175. Is the enteral replacement of externally drained pancreatic juice valuable after panreatoduodenectomy? Reviewed

    Yokoyama Y, Ebata T, Igami T, Sugawara G, Nagino M

    Yokoyama Y   Vol. 44 ( 2 ) page: 252-259   2014.2

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  176. Prognostic delineation of papillary cholangiocarcinoma based on the invasive proportion: a single-institution study with 184 patients. Reviewed

    Onoe S, Shimoyama Y, Ebata T, Yokoyama Y, Igami T, Sugawara G, Nakamura S, Nagion M.

    Surgery   Vol. 155 ( 2 ) page: 280-291   2014.2

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  177. Randomized clinical trial on the effect of perioperative synbiotics versus no synbiotics on bacterial translocation after oesophagectomy. Reviewed

    Yokoyama Y, Nishigaki E, Abe T, Fukaya M, Asahara T, Nomoto K, Nagino M.

    British Journal of Surgery   Vol. 101 ( 3 ) page: 189-199   2014.2

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  178. Role of anatomical right hepatic trisectionectomy for perihilar cholangiocarcinoma. Reviewed

    Matsumoto N, Ebata T, Yokoyama Y, Igami T, Sugawara G, Shimoyama Y, Nagino M.

    British Journal of Surgery   Vol. 101 ( 3 ) page: 261-268   2014.2

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  179. Inihibition of Tol-like receptor 4 suppresses liver injury induced by biliary obstruction and subsequent intraportal lipopolysaccharide injection. Reviewed

    Oya S, Yokoyama Y, Kokuryo T, Uno M, Yamauchi K, Nagino M.

    Am J Physiol Gastrointest Liver Physiol.   Vol. 306 ( 3 ) page: G244-252   2014.2

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  180. The determination of bile leakage in complex hepatectomy based on the guidelines of the International Study Group of Liver Surgery. Reviewed

    Taguchi Y, Ebata T, Yokoyama Y, Igami T, Sugawara G, Kokuryo T, Wakai K, Nagino M.

    World Journal of Surgery   Vol. 38 ( 1 ) page: 168-176   2014.1

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  181. Inflammation increases cells expressing ZSCAN4 and progenitor-cell markers in the adult pancreas.

    Ko S, Azuma S, Yokoyama Y, Yamamoto A, Kyokane K, Niida S, Ishiguro H, Ko M.

    Am J Physiol Gastrointest Liver Physiol   Vol. 304 ( 12 ) page: G1103-16   2013.12

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  182. Quantitiative proteomic profiling identifies DPYSL3 as pancreatic ductal adenocarcinoma-associated molecule that regulates cell adhesion and migration by stabilization of focal adhesion complex. Reviewed

    Kawahara T, Hotta N, Ozawa Y, Kato S, Kano K, Yokoyama Y, Nagino M, Takahashi T, Yanagisawa K.

    PLOS ONE   Vol. 8 ( 12 ) page: e79654   2013.12

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  183. Hepatobiliary resection with concomitant resection of the inferior vena cava for advanced intrahepatic cholangiocarcinoma: report of a case. Reviewed

    Nakagawa A, Igami T, Sugawara G, Ebata T, Yokoyama Y, Takahashi Y, Ando H, Nagino M.

    Surgery Today   Vol. 43 ( 11 ) page: 1321-1325   2013.11

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  184. Combination therapy with single incision laparoscopic surgery and double-balloon endoscopy for small intestinal bleeding: report of three cases. Reviewed

    Uehara K, Yoshioka Y, Ebata T, Yokoyama Y, Nakamura M, Ohmiya N, Goto H, Nagino M.

    Surgery Today   Vol. 43 ( 9 ) page: 1062-1065   2013.9

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  185. Evolution of surgical treatment for perihilar cholangiocarcinoma: A single-center 34-year review of 574 consecutive resections. Reviewed

    Nagino M, Ebata T, Yokoyama Y, Igami T, Sugawara G, Takahashi Y, Nimura Y.

    Annals of Surgery   Vol. 258 ( 4 ) page: 129-140   2013.7

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  186. Salvage hepatectomy for perihilar malignancy treated initially with biliary self-expanding metallicv stents.

    Fukami Y, Ebata T, Yokoyama Y, Igami T, Sugawara G, Nagino M.

    Surgery   Vol. 153 ( 5 ) page: 627-633   2013.5

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  187. Assessment of nodal status for perihilar cholangiocarcinoma: Location, number, or ratio of involved nodes.

    Aoba T, Ebata T, Yokoyama Y, Igami T, Sugawara G, Takahashi Y, Nimura Y, Nagino M.

    Annals of Surgery   Vol. 257 ( 4 ) page: 718-725   2013.4

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  188. Protective effects of banched-chain amino acids on hepatic ischemia-reperfusion-induced liver injury in rats: a direct attenuation of Kupffer cell activation.

    Kitagawa T, Yokoyama Y, Kokuryo T, Nagino M.

    Am J Physiol Gastrointest Liver Physiol   Vol. 304 ( 4 ) page: G346-355   2013.4

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  189. Surgical treatment of perihilar cholangiocarcinoma in octogenarians: a single center experience.

    Takahashi Y, Ebata T, Yokoyama Y, Igami T, Sugawara G, Nagino M.

    J Hepatobiliary Pancreat Sci   Vol. 20 ( 3 ) page: 324-331   2013.3

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  190. The effect of preoperative biliary drainage on infectious complications after hepatobiliary resection with choangiojejunostomy.

    Sugawara G, Ebata T, Yokoyama Y, Igami T, Takahashi Y, Takara D, Nagino M.

    Surgery   Vol. 153 ( 2 ) page: 200-210   2013.2

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  191. Endothelial nitric oxide synthase plays a main role in producing nitric oxide in the super-acute phase of hepatic ischemia prior to the upregulation of inducible nitric oxide synthase.

    Miyake T, Yokoyama Y, Kokuryo T, Mizutani T, Imamura A, Nagino M.

    Journal of Surgical Research   Vol. 183 ( 2 ) page: 742-51   2013.2

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  192. Single-incision laparoscopic cholecystectomy for porcelain gallbladder: A case report.

    Igami T, Usui H, Ebata T, Yokoyama Y, Sugawara G, Takahashi Y, Nagino M.

    Asian J Endosc Surg   Vol. 6 ( 1 ) page: 52-54   2013.2

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  193. Calcitonin gene-related peptide regulates the early phase of liver regeneration.

    Mizutani T, Yokoyama Y, Kokuryo T, Kawai K, Miyake T, Nagino M.

    Journal of Surgical Research   Vol. 183 ( 1 ) page: 138-45   2013.1

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  194. Seven-signal proteomic signature for detection of operable pancreatic ductal adenocarcinoma and their discrimination from autoimmune pancreatitis.

    Yanagisawa K, Tomida S, Matsuo K, Arima C, Kusumegi M, Yokoyama Y, Ko SB, Mizuno N, Kawahara T, Kuroyanagi Y, Takeuchi T, Goto H, Yamao K, Nagino M, Tajima K, Takahashi T.

    International Journal of Proteomics     page: in press   2013

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  195. An increased VWF/ADAMTS14 ratio may predict postoperative thrombotic complications following major hepatectomy.

    Kobayashi S, Yokoyama Y, Matsushita T, Kainuma M, Ebata T, Igami T, Sugawara G, Takahashi Y, Nagino M.

    Archives of Surgery   Vol. 147 ( 10 ) page: 909-917   2012.10

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  196. Hepatopancreatoduodenectomy for cholangiocarcinoma: A single-center review of 86 consecutive patients.

    Ebata T, Yokoyama Y, Igami T, Sugawara G, Takahashi Y, Nimura Y, Nagino M.

    British J Surgery   Vol. 256 ( 2 ) page: 297-305   2012.8

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  197. Toward a new concept of liver surgery: Real-time monitoring of liver damage during ischemia-reperfusion using a nitric oxide sensor in rat liver.

    Nakagawa A, Yokoyama Y, Suzuki H, Shoji K, Watanabe Y, Kokuryo T, Nagino M.

    British J Surgery   Vol. 99 ( 8 ) page: 1120-1128   2012.8

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  198. Clinical significance of left trisectionectomy for perihilar cholangiocarcinoma: an appraisal and comparison with left hepatectomy. Reviewed

    Natsume S, Ebata T, Yokoyama Y, Igami T, Sugawara G, Shimoyama Y, Nagino M.

    Annals of Surgery   Vol. 255 ( 4 ) page: 754-762   2012.4

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  199. Diagnostic ability of MDCT to assess right hepatic artery invasion by perihilar cholangiocarcinoma with left-sided predominance. Reviewed

    Fukami Y, Ebata T, Yokoyama Y, Igami T, Sugawara G, Takahashi Y, Suzuki K, Nagino M.

    J Hepatobiliary Pancreat Sci.   Vol. 19 ( 2 ) page: 179-186   2012.3

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  200. Locally recurrent rectal cancer successfully treated by total pelvic exenteration with combined ischiopubic rami resection : report of a case. Reviewed

    Uehara K, Yoshioka Y, Taguchi Y, Igami T, Ebata T, Yokoyama Y, Sugawara G, Tsukushi S, Nishida Y, Yoshino Y, Nagino M.

    Jpn J Clin Oncol.   Vol. 42 ( 1 ) page: 58-62   2012.1

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  201. Adipose tissue-derived mesenchymal stem cell transplantation promotes hepatic regeneration following hepatic ischemia-reperfusion and subsequent hepatectomy in rats.

    Seki T, Yokoyama Y, Nagsasaki H, Kokuryo T, Nagino M.

    Journal of Surgical Research   Vol. 178 ( 1 ) page: 63-70   2012.1

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  202. Portal vein embolization before extended hepatectomy for biliary cancer: Current technique and review of 494 consecutive embolizations. Reviewed

    Ebata T, Yokoyama Y, Igami T, Sugawara G, Takahashi Y, Nagino M.

    Digestive Surgery   Vol. 29   page: 23-29   2012

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  203. Antitumor effects of alpha-bisabolol against pancreatic cancer. Reviewed

    Seki T, Kokuryo T, Yokoyama Y, Suzuki H, Itatsu K, Nakagawa A, Mizutani T, Miyake T, Uno M, Yamauchi K, Nagino M.

    Cancer Science   Vol. 102 ( 12 ) page: 2199-2205   2011.12

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  204. Staging of peripheral-type intrahepatic cholangiocarcinoma: Appraisal of the new TNM classification and its modifications. Reviewed

    Igami T, Ebata T, Yokoyama Y, Sugawara G, Takahashi Y, Nagion M.

    World J Surg.   Vol. 35 ( 11 ) page: 2501-2509   2011.11

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  205. Hepatolithiasis in the hepatic hilum mimicking hilar cholangiocarcinoma: A case report-Intrahepatic stone of unusual appearance-. Reviewed

    Senda Y, Nishio H, Ebata T, Yokoyama Y, Igami T, Sugawara G, Nagino M.

    Surgery Today   Vol. 41 ( 9 ) page: 1243-1246   2011.9

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  206. Post-hepatectomy hemorrhage : a definition and grading by the international study group of liver surgery (ISGLS). Reviewed

    Rahbari NN, Garden OJ, Padbury R, Maddern G, Koch M, Hugh TJ, Fan ST, Nimura Y, Figueras J, Vauthey JN, Rees M, Adam R, DeMatteo RP, Greig P, Usatoff V, Banting S, Nagino M, Capussotti L, Yokoyama Y, Brooke-Smith M, Crawford M, Christophi C, Makuuchi M, Büchler MW, Weitz J.

    HPB (Oxford).   Vol. 13 ( 8 ) page: 528-535   2011.8

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  207. Supraportal right posterior hepatic artery: an anatomic trap in hepatobiliary and transpolant surgery. Reviewed

    Yoshioka Y, Ebata T, Yokoyama Y, Igami T, Sugawara G, Nagino M.

    World Journal of Surgery.   Vol. 35 ( 6 ) page: 1340-1344   2011.6

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  208. Posthepatectomy liver failure: A definition and grading by the International Study Group of Liver Surgery (ISGLS). Reviewed

    Rahbari NN, Garden OJ, Padbury R, Brooke-Smith M, Crawford M, Adam R, Koch M, Makuuchi M, Dematteo RP, Christophi C, Banting S, Usatoff V, Nagino M, Maddern G, Hugh TJ, Vauthey JN, Greig P, Rees M, Yokoyama Y, Fan ST, Nimura Y, Fiqueras J, Capussotti L, Buchler MW, Weitz J.

    Surgery   Vol. 149 ( 5 ) page: 713-724   2011.5

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  209. Bile leakage after hepatobiliary and pancreatic surgery: A definition and grading of severity by the International Study Group of Liver Surgery (ISGLS). Reviewed

    Koch M, Garden OJ, Padbury R, Rahbari NN, Adam R, Capussotti L, Fan ST, Yokoyama Y, Crawford M, Makuuchi M, Christophi C, Banting S, Brooke-Smith M, Usatoff V, Nagino M, Maddern G, Hugh TJ, Vauthey JN, Greig P, Rees M, Nimura Y, Fiqueras J, Dematteo RP, Buchler MW, Weitz J.

    Surgery   Vol. 149 ( 5 ) page: 680-688   2011.5

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  210. Gallbladder cancer involving the extrahepatic bile duct is worthy of resection. Reviewed

    Nishio H, Ebata T, Yokoyama Y, Igami T, Sugawara G, Nagino M.

    Annals of Surgery.   Vol. 253 ( 5 ) page: 953-960   2011.5

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  211. Preoperative biliary MRSA infection in patients undergoing hepatobiliary resection with cholangiojejunostomy: incidence, antibiotic treatment, and surgical outcome. Reviewed

    Takara D, Sugawara G, Ebata T, Yokoyama Y, Igami T, Nagino M.

    World Journal of Surgery.   Vol. 35 ( 4 ) page: 850-857   2011.4

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  212. Segmental cholangitis impairs hepatic regneration capacity following partial hepatectomy in rats. Reviewed

    Watanabe K, Yokoyama Y, Kokuryo T, Kawai K, Kitagawa T, Seki T, Nakagawa A, Nagino M.

    HPB (Oxford).   Vol. 12 ( 1 ) page: 664-673   2010.12

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  213. Intraoperative bacterial translocation detected by bacterium-specific ribosomal RNA-targeted RT-PCR for the mesenteric lymph node strongly predicts postoperative infectious complications following major hepatectomy for biliary malignancies. Reviewed

    Mizuno T, Yokoyama Y, Nishio H, Ebata T, Sugawara G, Asahara T, Nomoto K, Nagino M.

    Annals of Surgery   Vol. 252 ( 6 ) page: 1013-1019   2010.12

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  214. Suppression of TLK1 expression sensitizes cholangiocarcinoma cells to cisplatin-induced apoptosis. Reviewed

    Takayama Y, Kokuryo T, Yokoyama Y, Ito S, Nagino M, Hamaguchi M, Senga T.

    Cancer Letter   Vol. 296 ( 1 ) page: 27-34   2010.10

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  215. Cytoplasmic expression of the JM403 antigen GlcAGlcNH3 on heparan sulfate glycosaminoglycan in mammary carcinomas a novel proliferative biomarker for breast cancers with high malighnancy. Reviewed

    Fujii M, Yusa A, Yokoyama Y, Kokuryo T, Tsunoda N, Oda K, Nagino M, Ishimaru T, Shimoyama Y, Utsunomiya H, Iwata H, Itoh Y, Itoh J, Kannagi R, Kyogashima M.

    Glycoconj J.   Vol. 27 ( 7-9 ) page: 661-672   2010.10

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  216. Surgical treatment of hilar cholangiocarcinoma in the new era. The Nagoya University experience. Reviewed

    Igami T, Nishio H, Ebata T, Yokoyama Y, Sugawara G, Nimura Y, Nagino M.

    J Hepatobiliary Pancreat Surg   Vol. 17 ( 4 ) page: 449-454   2010.7

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  217. Surgical treatment of hilar cholangiocarcinoma in the new era. The Nagoya University experience. Reviewed

    Igami T, Nishio H, Ebata T, Yokoyama Y, Sugawara G, Nimura Y, Nagino M.

    J Hepatobiliary Pancreat Surg.   Vol. 17 ( 4 ) page: 449-454   2010.7

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  218. Suppression of TLK1 expression sensitizes cholangiocarcinoma cells to cisplatin-induced apoptosis. Reviewed

    Takayama Y, Kokuryo T, Yokoyama Y, Ito S, Nagino M, Hamaguchi M, Senga T.

    Cancer Letter   Vol. 296 ( 1 ) page: 27-34   2010.7

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  219. A novel combination treatment for colorectal cancer using Nek2 siRNA and cisplatin. Reviewed

    Suzuki K, Kokuryo T, Senga T, Yokoyama Y, Nagino M, Hamaguchi M.

    Cancer Science   Vol. 101 ( 5 ) page: 1163-1169   2010.5

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  220. Inchinkoto, an herbal medicine, exerts beneficial effects in the rat liver under stress with hepatic ischemia-reperfusion and subsequent hepatectomy. Reviewed

    Kawai K, Yokoyama Y, Kokuryo T, Watanabe K, Kitagawa T, Nagino M.

    Annals of Surgery   Vol. 251 ( 4 ) page: 692-700   2010.4

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  221. Future liver remnant ICG clearance in predicting outcome in biliary cancer surgery. Reviewed

    Yokoyama Y, Nishio H, Ebata T, Igami T, Sugawara G, Nagino M.

    Br J Surg   Vol. 97 ( 8 ) page: 1260-1268   2010.4

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  222. 15-Deoxy-delta12,14-prostaglandin J2 prevents inflammatory response and endothelial cell damage in rats with acute obstructive cholangitis. Reviewed

    Watanabe K, Yokoyama Y, Kokuryo T, Kawai K, Kitagawa T, Seki T, Nakagawa A, Nagino M.

    Am J Physiol Gastrointest Liver Physiol   Vol. 298 ( 3 ) page: G410-418   2010.3

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  223. Using the greater omental flap to cover the cut surgace of the liver for prevention of delayed gastric emtpying after left-sided hepatobiliary resection: a prospective randomized controlled trial. Reviewed

    Igami T, Nishio H, Ebata T, Yokoyama Y, Sugawara G, Nagino M.

    J Hepatobiliary Pancreat Sci.   Vol. 18 ( 2 ) page: 176-183   2010.3

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  224. Estrogen promotes hepatic regeneration via activating serotonergic signal following portal vein branch ligation in rats. Reviewed

    Kitagawa T, Yokoyama Y, Kawai T, Nagino M, Nimura Y.

    Shock   Vol. 31 ( 6 ) page: 648-651   2009.6

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  225. Advances in the treatment of pancreatic cancer. Limiations of surgery and evaluation of new therapeutic strategies. Reviewed

    Yokoyama Y, Nimura Y, Nagino M.

    Surgery Today   Vol. 39 ( 6 ) page: 466-475   2009.5

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  226. Clinicopathologic study of cholangiocarcinoma with superficial spread. Reviewed

    Igami T, Nagino M, Oda K, Nishio H, Ebata T, Yokoyama Y, Shimoyama Y.

    Annals of Surgery   Vol. 249 ( 2 ) page: 296-302   2009.2

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  227. Nek2 as a novel molecular target for the treatment of breast cancer. Reviewed

    Tsunoda N, Kokuryo T, Oda K, Senga T, Yokoyama Y, Nagino M, Nimura Y, Hamaguchi M.

    Cancer Science   Vol. 100 ( 1 ) page: 111-116   2009.1

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  228. A rare surgical case of multiple liver resections for recurrent liver metastases from pancreatic gastrinoma: liver and vena cava resection. Reviewed

    Pachera S, Yokoyama Y, Nishio H, Oda K, Ebata T, Igami T, Abe T, Singu Y, Nagino M.

    J Hepatobiliary Pancreat Surg   Vol. 16 ( 5 ) page: 692-698   2009

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    Language:English   Publishing type:Research paper (scientific journal)  

  229. Papillary hyperplasia of the gallbladder in pancreaticobiliary maljunction represents a senescence-related lesion induced by lysolecithin. Reviewed

    Yamaguchi J, Sasaki M, Harada K, Zen Y, Sato Y, Ikeda H, Itatsu K, Yokoyama Y, Ando H, Ohta T, Kukbota A, Shimizu K, Nimura Y, Nagino M, Nakanuma Y.

    Laobratory Investigation   Vol. 89 ( 9 ) page: 1018-1031   2009

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  230. Treatment of pancreatic fistula after pancreatoduodenectomy using a hand-made T-tube. Reviewed

    Igami T, Kamiya Y, Yokoyama Y, Nishio H, Ebata T, Sugawara G, Nimura Y, Nagino M.

    J Hepatobiliary Pancreat Surg   Vol. 16 ( 5 ) page: 661-667   2009

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  231. Small pancreatic carcinoma misdiagnosed as superficially spreading cholangiocarcinoma. Reviewed

    Igami T, Yokoyama Y, Nishio H, Ebata T, Shimoyama Y, Nakamura S, Nagino M.

    J Hepatobiliary Pancreat Surg   Vol. 16 ( 4 ) page: 579-584   2009

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  232. A left hepatectomy and caudate lobectomy combined resection of the ventral segment of the right anterior sector for hilar cholangiocarcinoma. The efficacy of portal vein embolization in identifying the hepatic subsegment. Report of a case. Reviewed

    Igami T, Yokoyama Y, Nishio H, Ebata T, Sugawara G, Senda Y, Oda K, Abe T, Uehara K, Nagino M.

    Surgery Today   Vol. 39 ( 7 ) page: 628-632   2009

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  233. Value of multidetector row CT in the assessment of longitudinal extension of cholangiocarcionoma. Correlation between MDCT and microscopic findings. Reviewed

    Senda Y, Nihio H, Oda K, Yokoyama Y, Ebata T, Igami T, Sugiura T, Shimoyama Y, Nimura Y, Nagino M.

    World Journal of Surgery   Vol. 33 ( 7 ) page: 1459-1467   2009

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  234. Superextended hepatectomy for resection of multiple giant hemangiomas: report of a case. Reviewed

    Pachera S, Nishio H, Yamada H, Yokoyama Y, Ebata T, Igami T, Abe T, Matsubara H, Koutarou H, Nagino M.

    Surgery Today   Vol. 39 ( 5 ) page: 452-455   2009

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  235. Choleretic effect of Inchin-ko-to (ICKT) for the patients with biliary obstruction due to bile duct carcinoma. Reviewed

    Watanabe S, Yokoyama Y, Oda K, Kokuryo T, Shoda J, Okada K, Utsunomiya H, Nagino M.

    Hepatology Research   Vol. 39   page: 247-255   2009

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  236. A patients with gallbladder cancer with para-aortic lympn node and hepatic metastasis who has survived more than twelve years after the primary extended radical operation. Reviewed

    Amemiya T, Yokoyama Y, Nagino M, Oda K, Nishio H, Ebata T, Igami T, Abe T, Nimura Y.

    J Hepatobiliary Pancreat Surg   Vol. 15 ( 6 ) page: 648-651   2008.11

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  237. Undifferentiated embryonal liver sarcoma: A case report and review of the literatures. Reviewed

    Pachera S, Nishio H, Takahashi Y, Yokoyama Y, Oda K, Ebata T, Igami T, Nagino M

    J Hepatobiliary Pancreat Surg   Vol. 15 ( 5 ) page: 536-544   2008.10

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  238. Value of multidetector-row computed tomography in diagnosis of portal vein invasion by perihilar cholangiocarcinoma. Reviewed

    Sugiura T, Nishio H, Nagino M, Senda Y, Ebata T, Yokoyama Y, Igami T, Oda K, Nimura Y.

    World J Surg   Vol. 32 ( 7 ) page: 1478-1484   2008.7

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  239. The role of estrogen receptor subtypes on hepatic neutrophil accumulation following trauma-hemorrhage: Direct modulation of CINC-1 production by Kupffer cells. Reviewed

    Shimizu T, Suzuki T, Yu HP, Yokoyama Y, Choudhry MA, Bland KI, Chaudry IH.

    Cytokine   Vol. 43 ( 1 ) page: 88-92   2008.7

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  240. Pancreatic metastasis from renal cell carcinoma: results of the surgical management and pathologic findings. Reviewed

    Koide N, Yokoyama Y, Nagino M, Nimura Y.

    Pancreas   Vol. 37 ( 1 ) page: 104-107   2008.7

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  241. Upregulated thromboxane production in the rat liver with biliary obstruction does not contribute to promote hepatic injury. Reviewed

    Yokoyama Y, Kawai T, Kawai S, Kitagawa T, Watanabe K, Kiyotaka K, Nagino M.

    Shock   Vol. 29 ( 6 ) page: 688-691   2008.6

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  242. MEK inhibitor, U0126, enhances the inhibitory effect of imatinib on pancreatic cancer cell growth. Reviewed

    Takayama Y, Kokuryo T, Yokoyama Y, Nagino M, Nimura Y, Senga T, Hamaguchi M.

    Cancer Letter   Vol. 264 ( 2 ) page: 241-249   2008.6

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  243. Sex dimorphism in the outcome of preoperative right portal vein embolization. Reviewed

    Yokoyama Y, Nagino M, Oda K, Nishio H, Ebata T, Abe T, Igami T, Nimura Y

    Arch Surg   Vol. 143 ( 3 ) page: 254-259   2008

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    This original article analyzed gender dimorphism for more than 80 cases of right portal vein embolization.

  244. New classification of cystic duct carcinoma. Reviewed

    Yokoyama Y, Nagino M, Oda K, Nishio H, Ebata T, Igami T, Abe T, Nimura Y

    World J Surg   Vol. 32 ( 4 ) page: 621-626   2008

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  245. Nek3 as an effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma. Reviewed

    Kokuryo T, Senga T, Yokoyama Y, Nagino M, Nimura Y, Hamaguchi M

    Cancer Research   Vol. 67 ( 20 ) page: 9637-9642   2007.10

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  246. Recent advances in treatment of hilar cholangiocarcinoma: Portal vein embolization. Invited Reviewed

    Yokoyama Y, Nagino M, Yuasa N, Oda K, Nishio H, Ebata T, Igami T, Nimura Y

    J HPB Surg   Vol. 14 ( 5 ) page: 447-454   2007.9

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  247. Which gender is better positioned in the process of liver surgery? Male or female? Invited Reviewed

    Yokoyama Y, Nagino M, Nimura Y

    Surg Today   Vol. 37   page: 823-830   2007.9

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  248. Clinicopathologic features of re-resected cases of intraductal papillary mucinous neoplasms (IPMNs). Reviewed

    Yokoyama Y, Nagino M, Nishio H, Ebata T, Abe T, Igami T, Nimura Y

    Surgery   Vol. 142 ( 2 ) page: 136-142   2007.8

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    This original article analyzed and elucidated the clinicopathologic features of one hundred consecutive cases of intraductal papillary mucinous neoplasms in our institution.

  249. Mechanism of impaired hepatic regeneration in cholestatic liver. Invited Reviewed

    Yokoyama Y, Nagino M, Nimura Y

    J HPB Surg   Vol. 14 ( 2 ) page: 159-166   2007.3

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  250. The mechanism of oxygen radical-mediated bile flow reduction: the role of intracellular cyclic AMP. Reviewed

    Kawai S, Arai T, Yokoyama Y, Nagino M, Nimura Y

    J Gastroenterol Hepatol   Vol. 22 ( 3 ) page: 429-435   2007.3

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  251. Mechanisms of hepatic regeneration comparing partial hepatectomy and portal vein embolization: A review. Reviewed

    Yokoyama Y, Nagino M, Nimura Y

    W J Surg   Vol. 31 ( 2 ) page: 367-374   2007.2

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  252. Does estrogen contribute to hepatic regeneration following portal vein ligation? Reviewed

    Kawai T, Yokoyama Y, Kawai S, Yokoyama S, Oda K, Nagasaka T, Nagino M, Chaudry IH, Nimura Y

    Am J Physiol Gastrointest Liver Physiol   Vol. 292 ( 2 ) page: G582-589   2007.2

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  253. Is there any effect of renal failure on the hepatic regeneration capacity following partial hepatectomy in rats? Reviewed

    Kawai T, Yokoyama Y, Kitagawa T, Nagino M, Nimura Y.

    Biochem Biophysic Res Commun   Vol. 352 ( 2 ) page: 311-316   2007.1

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  254. Intrahepatic cholangiojejunostomy following hepatobiliary resection: Results in 423 consecutive cases. Reviewed

    Nagino M, Nishio H, Ebata T, Yokoyama Y, Igami T, Nimura Y

    Br J Surg   Vol. 94 ( 1 ) page: 70-77   2007.1

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  255. Pancreatic and duodenal invasion in distal bile duct cancer: Paradox in the tumor classification of the American Joint Committee on Cancer. Reviewed

    Ebata T, Nagino M, Nishio H, Igami T, Yokoyama Y, Nimura Y.

    World J Surg   Vol. 31 ( 10 ) page: 2008-2015   2007

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  256. Infraportal bile duct of the caudate lobe. A troublesome anatomic variation in right sided hepatectomy for perihilar cholangiocarcinoma.

    Sugiura T, Nagino M, Kamiya J, Nishio H, Ebata T, Yokoyama Y, Igami T, Nimura Y

    Ann Surg   Vol. 246 ( 5 ) page: 794-798   2007

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  257. Aggressive surgery for stage IV gallbladder carcinoma; what are the contraindications? Reviewed

    Nishio H, Nagino M, Ebata T, Yokoyama Y, Igami T, Nimura Y

    J HPB Surg   Vol. 14 ( 4 ) page: 351-357   2007

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  258. Hepati arterial flow becomes the primary supply of sinusoids following partial portal vein ligation. Reviewed

    Yokoyama Y, Wawrzyniak A, Sarmadi AM, Baveja R, Gruber HE, Clemens MG, Zhang JX.

    J Gastroenterol Hepatol   Vol. 21 ( 10 ) page: 1567-1574   2006.10

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  259. Biphasic activation of liver regeneration-associated signals at an early stage after portal vein branch ligation. Reviewed

    Yokoyama S, Yokoyama Y, Kawai T, Kobayashi S, Nagino M, Oda K, Nimura Y, Sokabe M.

    Biochem Biophysic Res Commun   Vol. 349 ( 2 ) page: 732-739   2006.10

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  260. Evaluation of hepatic interleukin-6 secretion following portal branch ligation using a minimal surgical stress model. Reviewed

    Kobayashi S, Nagino M, Yokoyama Y, Nimura Y, Sokabe M.

    J Surg Res   Vol. 135 ( 1 ) page: 27-33   2006.9

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  261. Disruption of phospholipase C delta 4 gene modulates the liver regeneration in cooperation with nuclear protein kinase C. Reviewed

    Akutagawa A, Fukami K, Banno Y, Takenawa T, Kannagi R, Yokoyama Y, Oda K, Nagino M, Nimura Y, Yoshida S, Tamiya-Koizumi K.

    J Biochem   Vol. 140 ( 5 ) page: 619-625   2006

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  262. Role of thromboxane in producing hepatic injury during hepatic stress. Invited Reviewed

    Yokoyama Y, Nimura Y, Nagino M, Bland KI, Chaudry IH

    Arch Surg   Vol. 140 ( 8 ) page: 801-807   2005.8

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  263. Intense PET signal in the degenerative necrosis superimposed on chronic pancreatitis. A case report. Reviewed

    Yokoyama Y, Nagino M, Yuasa N, Oda k, Arai T, Nishio H, Ebata T, Nimura Y

    Pancreas   Vol. 31 ( 2 ) page: 192-194   2005.8

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  264. Current understanding of gender dimorphism in hepatic pathophysiology. Invited Reviewed

    Yokoyama Y, Nimura Y, Nagino M, Bland KI, Chaudry IH

    J Surg Res   Vol. 128   page: 147-156   2005

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    This review article summarized the current understanding of gender difference in the hepatic pathophysiology especially focused on the condition of hepatic vascular stress.

  265. Insights into the role of IL-6 in the induction of hepatic injury after trauma-hemorrhagic shock. Reviewed

    Toth B, Yokoyama Y, Schwacha MG, George RL, Rue III LW, Bland KI, Chaudry IH

    J Appl Physiol   Vol. 97 ( 6 ) page: 2184-2189   2004.12

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  266. Estradiol's effects on portal response to endothelin-1 after trauma-hemorrhage. Reviewed

    Yokoyama Y, Toth B, Kitchens WC, Schwacha MG, Rue LW 3rd, Bland KI, Chaudry IH

    J Surg Res   Vol. 121 ( 1 ) page: 25-30   2004.9

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    This article investigated the effect of estrogen treatment on the action of endothelin in the portal venous system following trauma-hemorrhage.

  267. Remote trauma sensitizes hepatic microcirculation to endothelin via caveolin inhibition of eNOS activity. Reviewed

    Ashburn JH, Baveja R, Kresge N, Korneszczuk K, Keller S, Karaa A, Yokoyama Y, Zhang JX, Huynh T, Clemens MG

    Shock   Vol. 22 ( 2 ) page: 120-130   2004.8

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  268. Alpha1-acid-glycoprotein protects against trauma-hemorrhagic shock. Reviewed

    Kuebler JF, Toth B, Yokoyama Y, Bland KI, Rue LW, Chaudry IH

    J Surg Res   Vol. 119 ( 1 ) page: 21-28   2004.6

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  269. The role of IL-10 in regulating proinflammatory cytokine release by Kupffer cells following trauma-hemorrhage. Reviewed

    Yokoyama Y, Toth B, Schwacha MG, Bland KI, Chaudry IH

    Am J Physiol   Vol. 286 ( 6 ) page: G942-946   2004.6

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  270. Gender differences in small intestinal endothelial function: The inhibitory role of androgens. Reviewed

    Ba ZF, Yokoyama Y, Toth B, Rue III LW, Bland KI, Chaudry IH

    Am J Physiol   Vol. 286 ( 3 ) page: G452-457   2004.3

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  271. Sex differences in hepatic heme oxygenase expression and activity following trauma and hemorrhagic shock. Reviewed

    Toth B, Yokoyama Y, Kuebler JF, Schwacha MG, Rue III LW, Bland KI, Chaudry IH

    Arch Surg   Vol. 138 ( 12 ) page: 1375-1382   2003.12

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  272. Upregulation of hepatic prolactin receptor gene expression by 17beta-estradiol following trauma- hemorrhage. Reviewed

    Yokoyama Y, Williams KC, Toth B, Schwacha MG, Bland KI, Chaudry IH

    J Appl Physiol   Vol. 95 ( 6 ) page: 2530-2536   2003.12

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  273. Effect of estradiol administration on splanchnic perfusion following trauma-hemorrhage and sepsis. Invited Reviewed

    Yokoyama Y, Schwacha MG, Bland KI, Chaudry IH

    Current Opinion in Critical Care   Vol. 9 ( 2 ) page: 137-142   2003.7

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  274. Administration of progesterone after trauma and hemorrhagic shock prevents hepatocellular injury. Reviewed

    Kuebler JF, Yokoyama Y, Jarrar D, Toth B, Bland KI, Rue III LW, Wang P, Chaudry IH

    Arch Surg   Vol. 138 ( 7 ) page: 727-734   2003.7

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  275. Role of thromboxane A2 (TXA2) in portal hypertension in bile duct ligated rat liver. Reviewed

    Yokoyama Y, Xu H, Kresge N, Sarmadi AH, Baveja R, Clemens MG, Zhang JX

    Am J Physiol   Vol. 284 ( 3 ) page: G453-460   2003.3

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  276. Role of thromboxane in producing portal hypertension following trauma-hemorrhage. Reviewed

    Yokoyama Y, Toth B, Kuebler JF, Schwacha MG, Bland KI, Chaudry IH

    Am J Physiol   Vol. 285 ( 6 ) page: G1293-1299   2003

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  277. The role of female sex hormones in preventing mortality in sepsis. Invited Reviewed

    Yokoyama Y, Schwacha MG, Bland KI, Chaudry IH

    Advances in Sepsis   Vol. 2   page: 127-132   2003

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  278. Mechanism of the salutary effects of 17beta-estradiolfollowing trauma-hemorrhage: Direct downregulation of Kupffer cell proinflammatory cytokine production. Reviewed

    Yokoyama Y, Kuebler JF, Matsutani T, Schwacha MG, Bland KI, Chaudry IH

    Cytokine   Vol. 21   page: 1-7   2003

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  279. Endothelin-1 and heme oxygenase-2 as modulators of sinusoidal tone in the stress-exposed rat liver. Reviewed

    Rensing H, Bauer I, Zhang JX Paxian M, Pannen BH, Yokoyama Y, Clemens MG, Bauer M

    Hepatology   Vol. 36 ( 6 ) page: 1453-1465   2002.12

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  280. Potentiated hepatic microcirculatory response to endothelin-1 during polymicrobial sepsis. Reviewed

    Baveja R, Kresge N, Ashburn JH, Keller S, Yokoyama Y, Sonin N, Zhang JX, Huynh T, and Clemens MG

    Shock   Vol. 18 ( 5 ) page: 415-422   2002.11

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  281. Endothelin impairs oxygen delivery in livers from LPS-primed animals. Reviewed

    Baveja R, Yokoyama Y, Zhang JX, Clemens MG

    Shock   Vol. 17 ( 5 ) page: 383-388   2002.5

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  282. LPS-induced imbalanced expression of hepatic vascular stress genes in cirrhosi: possible mechanism of increased susceptibilityto endotoxemia. Reviewed

    Baveja R, Yokoyama Y, Sonin N, Clemens MG, Zhang JX

    Shock   Vol. 17 ( 4 ) page: 316-321   2002.4

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  283. Endothelin receptor remodeling induces the portal venous hyper-response to endothelin-1 following endotoxin pretreatment. Reviewed

    Yokoyama Y, Baveja R, Kresge N, Sonin N, Nakanishi K, Zhang J, Gitzelmann C, Clemens MG

    Shock   Vol. 17 ( 1 ) page: 36-40   2002.1

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  284. Gender dimorphism in immune responses following trauma and hemorrhage. Invited Reviewed

    Yokoyama Y, Schwacha MG, Anantha Samy TS, Bland KI, Chaudry IH

    Immunologic Research   Vol. 26   page: 121-134   2002

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  285. Hepatic vascular response to elevated intraperitoneal pressure in the rat. Reviewed

    Yokoyama Y, Alterman DM, Sarmadi AH, Baveja B, Zhang JX, Huynh T, Clemens MG

    J Surg Res   Vol. 150 ( 2 ) page: 86-94   2002

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  286. Altered endothelin receptor expression in prehepatic portal hypertension predisposes the liver to microcirculatory dysfunction in rats. Reviewed

    Yokoyama Y, Wawrzyniak A, Baveja R, Sonin N, Clemens MG, Zhang JX

    J Hepatol   Vol. 35 ( 1 ) page: 29-36   2001.7

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  287. Neovascularization of hepatic arterioles following partial portal vein ligation: A novel mechanism of chronic regulation in hepatic blood flow. Reviewed

    Yokoyama Y, Baveja R, Sonin N, Clemens MG, Zhang JX

    Am J Physiol   Vol. 280   page: G21-31   2001

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  288. Functional significance of endothelin B receptors in mediating sinusoidal and extrasinusoidal effects of endothelins in the intact rat liver. Reviewed

    Bauer M, Bauer I, Sonin N, Kresge N, Baveja R, Yokoyama Y, Zhang J, Clemens MG

    Hepatology   Vol. 31 ( 4 ) page: 937-947   2000.4

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  289. Primary carcinoid tumor of the gallbladder: resection of a case metastasizing to the liver and analysis of outcomes. Reviewed

    Yokoyama Y, Fujioka S, Kato K, Tomono H, Yoshida K, Nimura Y

    Hepatogastroenterology   Vol. 47 ( 31 ) page: 135-139   2000.1

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  290. Altered endothelin receptor subtype expression in hepatic injury after ischemia/reperfusion. Reviewed

    Yokoyama Y, Baveja R, Sonin N, Zhang J, Clemens MG

    Shock   Vol. 13 ( 1 ) page: 72-78   2000.1

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  291. Thirty-six cases of obturator hernia; Does computed tomography contribute to postoperative outcome? Reviewed

    Yokoyama Y, Yamaguchi A, Isogai M, Hori A, Kaneoka Y.

    World J Surg   Vol. 23 ( 2 ) page: 214-216   1999.2

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▼display all

Books 17

  1. 患者さんのための膵がん診療ガイドラインの解説

    横山幸浩( Role: Sole author)

    金原出版  2015.5 

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    Language:Japanese

  2. 核酸医薬開発の現状と展望

    國料俊男、横山幸浩、梛野正人( Role: Joint author)

    飯田橋パピルス  2015 

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    Language:Japanese

  3. Cholangiocarcinoma

    Mizuno T, Ebata T, Yokoyama Y, Sugawara G, Nagino M.( Role: Joint author)

    Nova Science Publishers  2015 

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    Total pages:20   Language:English Book type:Textbook, survey, introduction

  4. 常在細菌叢が操るヒトの健康と疾患 高度外科侵襲手術における周術期シンバイティクス投与の有用性

    横山幸浩、梛野正人( Role: Joint author)

    羊土社  2014 

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    Language:Japanese

  5. The Current Scenario: Advanced Resectable Gallbladder Cancer, Diagnosis and Surgical Approach.

    Igami T, Ebata T, Yokoyama Y, Sugawara G, Nagino M.( Role: Joint author)

    Elsevier Clinical Advisory Board  2013 

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    Language:English

  6. 胆道がん 管理・治療・予後

    伊神剛、江畑智希、横山幸浩、菅原元、梛野正人( Role: Joint author)

    最新医学  2011 

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    Language:Japanese

  7. Venous Embolization of the Liver: Radiological and Surgical Practice. Biliary tract cancer.

    Yokoyama Y, Nagino M( Role: Joint author)

    2010.7 

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    Language:English

  8. Venous Embolization of the Liver: Radiological and Surgical Practice. Sequential PVE and TAE for biliary tract cancer and liver metastases.

    Yokoyama Y, Nagino M( Role: Joint author)

    Springer  2010.7 

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    Language:English

  9. An overview of pancreatic cancer

    Yukihiro Yokoyama( Role: Sole author)

    2010.1 

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    Language:Japanese

  10. 胆道外科の要点と盲点 第2版

    横山幸浩( Role: Joint author)

    文光堂  2009.1 

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    Language:Japanese

  11. Female Hepatology; Impact of female sex against progression of liver disease: Gender dimorphic response to hepatic vascular stress

    Yukihiro Yokoyama, Irshad H. Chaudry( Role: Joint author)

    RESEARCH SIGNPOST  2009 

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    Language:English

  12. Cancer Imaging Vol2. Chronic pancreatitis versus pancreatic cancer: positron emission tomography

    Yukihiro Yokoyama, Masato Nagino, Yuji Nimura( Role: Joint author)

    Elsevier  2008.1 

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    Language:English

  13. 消化器外科学レビュー: 最新文献と解説: 胆嚢炎、胆管炎

    横山幸浩、梛野正人( Role: Joint author)

    総合医学社  2008 

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    Language:Japanese

  14. 肝再生の開始機構は何か?

    横山幸浩、小林聡、笹本彰紀、河合正巳、梛野正人( Role: Joint author)

    先端医学社  2007.12 

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    Language:Japanese

  15. Endothelium Biomedicine. Trauma-hemorrhage and its effects on the endothelium with particular emphasis on gender dimorphism.

    Yukihiro Yokoyama, Irshad H. Chaudry( Role: Joint author)

    Cambridge University Press  2007.7 

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    Language:English

  16. がんの新辞典 からだの科学: 膵がん

    横山幸浩、梛野正人、二村雄次( Role: Joint author)

    日本評論社  2007 

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    Language:Japanese

  17. 消化器外科学レビュー: 最新文献と解説: 胆嚢炎、胆管炎

    横山幸浩、梛野正人、二村雄次( Role: Joint author)

    総合医学社  2007 

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    Language:Japanese

▼display all

Presentations 79

  1. Surgeon initiated basic science research for the mechanisms of biliary obstruction-induced liver injury. International conference

    Yokoyama Y

    24th World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists. 

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    Event date: 2014.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  2. A predictive power of prothrombin time and serum total bilirubin for postoperative mortality after major hepatectomy with extrahepatic bile duct resection. International conference

    Yokoyama Y, Ebata T, Igami T, Sugawara G, Mizuno T, Nagino M.

    11th World Congress of International Hepato-Pancreato-Biliary Association. 

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    Event date: 2014.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  3. The adverse effect of preoperative cholangitis on the outcome of portal vein embolization and subsequent major hepatectomy. International conference

    Yokoyama Y, Ebata T, Igami T, Sugawara G, Mizuno T, Nagion M.

    11th World Congress of International Hepato-Pancreato-Biliary Association. 

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    Event date: 2014.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  4. Perioperative synbiotics treatment reduces postoperative bacteremia through suppression of bacterial translocation following highly invasive surgeries. International conference

    Yokoyama Y

    Seoul International Symposium of Surgical Oncology 2014 

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    Event date: 2014.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  5. Surgical basic sciences for the treatment against hepato-biliary-pancreatic cancer. A research work conducted by active surgeons. International conference

    Yokoyama Y

    Seoul International Symposium of Surgical Oncology 2014 

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    Event date: 2014.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  6. Perioperative synbiotics treatment reduces postoperative bacteremia through suppression of bacterial translocation following highly invasive surgeries. International conference

    Yokoyama Y

    8th Asia Pacific Conference on Clinicla Nutrition (APCCN2013).  

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    Event date: 2013.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  7. Gene profile related to the inhibitory effects of alpha-Bisabolol on cellular invasion of pancreas cancer. International conference

    Yokoyama Y, Uno M, Kokuryo T, Nagino M.

    9th AACR-Japanese Cancer Association Joint Conference.  

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    Event date: 2013.2

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  8. Risk factors of incisional surgical site infection (I-SSI) in the elective hepato-pancreato-biliary surgery: A multi-institutional prospective study. International conference

    Yokoyama Y, Itatsu K, Kaneoka Y, Kato T, Kanai M, Sugawara G, Nagino M.

    Congress of the International Association of Surgeons, Gastroenterologists, and Oncologists (IASGO).  

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    Event date: 2012.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Thailand  

  9. The incidence of intraoperative bacterial translocation and its clinical impact on the postoperative course in highly invasive surgeries. International conference

    Yokoyama Y, Mizuno T, Abe T, Nishigaki E, Fukaya M, Asahara T, Nomoto K, Nagino M.

    22nd World Congress of the International Association of Surgeons, Gastroenterologists, and Oncologists (IASGO). 

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    Event date: 2012.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Thailand  

  10. Intraoperative bacterial translocation detected by bacterium-specific ribosomal RNA-targeted RTqPCR for the mesenteric lymph node strongly predicts postoperative infectious complications. International conference

    Yokoyama Y, Mizuno T, Sugawara G, Asahara T, Nomoto K, Nagino M.

    The 25th European Congress on Surgical Infection.  

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    Event date: 2012.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Sweden  

  11. The effects of segmental cholangitis on hepatic regeneration capacity following partial hepatectomy. International conference

    Yokoyama Y, Watanabe K, Kokuryo T, Kawai K, Kitagawa T, Nagino M.

    The 3rd Biennial Asian Pacific HPBA Congress 

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    Event date: 2011.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Australia  

  12. Beneficial effects of inchinkoto, a herbal medicine, against the stress of major liver surgery. International conference

    Yokoyama Y, Kawai K, Kokuryo T, Watanabe K, Kitagawa T, Nagino M.

    The 3rd Biennial Asian Pacific HPBA Congress. 

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    Event date: 2011.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Australia  

  13. Short-term outcomes of aggressive surgery for locally recurrent rectal cancer. International conference

    Uehara K, Ishiguro S, Nishio H, Ebata T, Yokoyama Y, Igami T, Sugawara G, Fukaya M, Itatsu K, Nagino M.

    The 15th European Society of Surgical Oncology.  

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    Event date: 2010.9

    Language:English   Presentation type:Poster presentation  

    Country:France  

  14. Investigation of gastroesophageal reflex diseases after distal gastrectomy with esophagogastric junction morphology, manometry, combined pH and bilirubin monitoring. International conference

    Fukaya M, Itatsu K, Uemura N, Miyata K, Ebata T, Yokoyama Y, Igami T, Sugawara G, Uehara K, Ishiguro S, Nagino M.

    The 12th World Congress of International Society for Diseases of the Esophagus.  

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    Event date: 2010.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  15. Margin length of the right posterior sectorial duct in left-sided hepatectomy for perihilar cholangiocarcinoma. International conference

    71. Natsume S, Ebata T, Sugawara G, Nishio H, Kokuryo T, Yokoyama Y, Tsunoda N, Fukaya M, Uehara K, Nagino M.

    9th World Congress of the International Hepato-Pancreato-Biliary Association. 

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    Event date: 2010.4

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  16. Hepatopancreatoduodenectomy for advanced gallbladder cancer: a Nagoya experience in the 2000s. International conference

    Ebata T, Nishio H, Yokoyama Y, Igami T, Sugawara G, Nimura Y, Nagino M.

    9th World Congress of the International Hepato-Pancreato-Biliary Association. 

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    Event date: 2010.4

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Argentina  

  17. Management of patients with MRSA-bactbilia for hepatobiliary resection. International conference

    9th World Congress of the International Hepato-Pancreato-Biliary Association 

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    Event date: 2010.4

    Language:English   Presentation type:Poster presentation  

    Country:Argentina  

  18. Combined hepatic artery resction for perihilar cholangiocarcinoma: histologic analysis in 59 patients. International conference

    Fukami Y, Ebata T, Nishio H, Yokoyama Y, Kokuryo T, Tsunoda N, Igami T, Sugawara G, Fukaya M, Uehara K, Shimoyama Y, Nagino M

    9th World Congress of the International Hepato-Pancreato-Biliary Association 

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    Event date: 2010.4

    Language:English   Presentation type:Poster presentation  

    Fukami Y, Ebata T, Nishio H, Yokoyama Y, Kokuryo T, Tsunoda N, Igami T, Sugawara G, Fukaya M, Uehara K, Shimoyama Y, Nagino M

  19. Nek2 as an effective molecular target for cancer treatment. International conference

    Kokuryo T, Senga T, Yokoyama Y, Nagino M, Hagaguchi M.

    The 101th American Association for Cancer Research.  

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    Event date: 2010.4

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  20. Cytoplasmic expression of Glc-GlcNh3+ on heparin sulfate closely correlates with malignancy of breast cancer. International conference

    Fujii M, Yuasa A, Yokoyama Y, Kokuryo T, Nagino M, Iwata H, Utsunomiya H, Ishimaru T, Kyogashima M, Knnagi R

    The 20th International Symposium on Glycoconjuate. 

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    Event date: 2009.11 - 2009.12

    Language:English   Presentation type:Poster presentation  

    Country:Puerto Rico  

  21. Nek2 as a novel molecular target for inhibition of tumorigenic growth and liver metastasis of pancreatic cancer. International conference

    Suzuki K, Kokuryo T, Senga T, Yokoyama Y, Nagino M, Hamaguchi M

    GASTRO 2009 UEGW/WCOG 

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    Event date: 2009.11

    Language:English   Presentation type:Poster presentation  

    Country:United Kingdom  

  22. 15-Deoxy-Δ12,14-Prostaglandin J2 prevents inflammatory response and endothelial cell damage in rats with acute obstructive cholangitis. International conference

    Yokoyama Y, Watanabe K, Kokuryo T, Kawai K, Kitagawa T, Seki T, Nakagawa A, Nagino M.

    60th Annual Meeting of The American Association for the Study of Liver Diseases 

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    Event date: 2009.10

    Language:English   Presentation type:Poster presentation  

  23. The mechanism of protective effect of PPAR gamma; activation on bile duct ligation-induced hepatic injury in rats. International conference

    60th Annual Meeting of The American Association for the Study of Liver Diseases 

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    Event date: 2009.10

    Language:English   Presentation type:Poster presentation  

  24. The value of ICG clearance rate of the future liver remnant in predicting postoperative morbidity following major hepatectomy for biliary cancer. International conference

    4th Annual Academic Surgical Congress 

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    Event date: 2009.3

    Language:English   Presentation type:Oral presentation (general)  

  25. Pancreatic and duodenal invasion in distal bile duct cancer: paradox in the tumor classification of the American Joint Committiee on Cancer. International conference

    8th World Congress of the International Hepato Pancreato Biliary Association 

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    Event date: 2008.2

    Language:English   Presentation type:Poster presentation  

    Country:India  

  26. Five-year survivors after surgery for gallbladder cancer involving the extrahepatic bile duct. International conference

    8th World Congress of the International Hepato Pancreato Biliary Association. 

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    Event date: 2008.2

    Language:English   Presentation type:Oral presentation (general)  

  27. Additional resection of margin-positive proximal bile duct does not improve survival in patients with hilar cholangiocarcinoma. International conference

    8th World Congress of the International Hepato Pancreato Biliary Association. 

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    Event date: 2008.2

    Language:English   Presentation type:Oral presentation (general)  

  28. Proposal of new classification for cystic duct carcinoma. International conference

    8th World Congress of the International Hepato Pancreato Biliary Association 

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    Event date: 2008.2

    Language:English   Presentation type:Oral presentation (general)  

  29. The role of PPAR gamma; in bile duct ligation-induced hepatic injury in rats. International conference

    American Association for the Study of Liver Diseases 

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    Event date: 2007.11

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  30. Major hepatectomy with resection of the hilar bile duct and/or portal bifurcation for liver metastasis from colorectal cancer. International conference

    The 11th Congress of Asian Federation of Coloproctology. 

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    Event date: 2007.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  31. Clinicopathologic features of recurrent intraductal papillary neoplasms (IPMNs). International conference

    1st Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association 

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    Event date: 2007.3

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  32. Does estrogen contribute to hepatic regeneration following portal branch ligation in rats? International conference

    1st Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association 

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    Event date: 2007.3

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  33. The new clinicopathological classification of mucin-producing bile duct tumors. International conference

    1st Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association 

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    Event date: 2007.3

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  34. Portal vein obstruction after hepatobiliary resection: countermeasure and treatment. International conference

    1st Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association 

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    Event date: 2007.3

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  35. Is there any effect of renal failure on the hepatic regeneration capacity following partial hepatectomy in rats. International conference

    2nd Academic Surgical Congress 

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    Event date: 2007.2

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  36. Clinicopathologic feature of recurrent cases of intraductal papillary mucinous neoplasms. Analysis of one hundred consecutive surgical cases in a single institution. International conference

    2nd Academic Surgical Congress 

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    Event date: 2007.2

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  37. Hepatic trisectionectomy for hilar cholangiocarcinoma: Is it worthwhile? International conference

    The 7th World Congress of the International Hepato-Pancreato Biliary Association 

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    Event date: 2006.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:United Kingdom  

  38. Mechanism of salutary effects of estradiol following trauma-hemorrhage. International conference

    3rd World Shock Forum 

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    Event date: 2006

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  39. The mechanism of oxygen radical-mediated bile flow reduction: the role of intracellular cyclic AMP. International conference

    FASEB 

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    Event date: 2005

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  40. Gender dimorphism in the outcome of preoperative portal embolization for major hepatectomy. International conference

    19th-World Congress of International Society for Digestive Surgery 

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    Event date: 2004

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  41. Pancreatic abscess in chronic pancreatitis with positron accumulation by FDG-PET-A case report. International conference

    The 11th Meeting of the International Association of Pancreatology 

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    Event date: 2004

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  42. Immunopathogenesis following trauma-hemorrhagic shock and possibilities of immune modulation.

    1st World Shock Forum 

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    Event date: 2003.10

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  43. Gender differences in small intestinal endothelial function: androgen plays an inhibitory role. International conference

    Shock 

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    Event date: 2003.6

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  44. IL-6 plays a ;major role in producing hepatic injury following trauma-hemorrhage. International conference

    Shock 

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    Event date: 2003.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  45. Portal venous response to endothelin-1 is attenuated by 17-estradiol treatment following trauma-hemorrhage. International conference

    Shock 

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    Event date: 2003.6

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  46. Gender dimorphism in hepatic heme oxygenase expression and activity after trauma and hemorrhagic shock. International conference

    Shock 

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    Event date: 2002.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  47. Mechanism of the salutary effect of 17beta-estradiol following trauma-hemorrhage: Direct downregulation of Kupffer cell IL-6 gene expression and release. International conference

    Shock 

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    Event date: 2002.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  48. Kuffper cells are the major source of thromboxane A2 (TXA2) in bile duct ligation induced cirrhosis. International conference

    FASEB 

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    Event date: 2002.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  49. Role of thromboxane A2 (TXA2) in portal hypertension in bile duct ligated rat liver. International conference

    America Association for the Study of Liver Diseases 

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    Event date: 2001.11

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  50. Altered in vivo response of the hepatic microcirculation to endothelin after remote trauma. International conference

    Shock 

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    Event date: 2001.6

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  51. Overexpression of Caveolin-1: a potential mechanism for a hyperresponse of hepatic microcirculation to endothelins during sepsis.

    Shock 

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    Event date: 2001.6

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  52. Hepatic vascular response to elevated intraperitoenal pressure in the rat. International conference

    FASEB 

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    Event date: 2001.3 - 2001.4

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  53. Altered vascular regulation in the hepatic portal circulation in fibrosis: role of nitric oxide and carbon monoxide.

    FASEB 

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    Event date: 2001.3 - 2001.4

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  54. Hepatic arterial flow as the primary blood supply feeding sinusoids in partial portal vein ligation (PPVL) induced portal hypertension. International conference

    FASEB 

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    Event date: 2001.3 - 2001.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  55. Remote trauma sensitizes hepatic microcirculation to endothelin: a potential mechanism for enhanced injury in sequential stresses. International conference

    Surgical Infection Society 

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    Event date: 2001

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  56. Low volume resuscitation exacerbates hepatic vascular stress gene dependent microvascular dysfunction in sepsis.

    34th Annual Meeting for the Association of Academic Surgenons 

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    Event date: 2000.11

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  57. Shunting of hepatic microcirculation after polymicrobial sepsis. International conference

    American College of Surgeon Surgical Forum 

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    Event date: 2000.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  58. Expression of vasoregulatory genes in the liver during progression of cirrhosis.

    FASEB 

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    Event date: 2000.4

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  59. Changes in expression of endothelin receptor subtypes in partial portal vein ligation-induced portal hypertension. International conference

    FASEB 

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    Event date: 2000.4

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  60. Hyporesponse of hepatic microcirculation to endothelin in sepsis. International conference

    FASEB 

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    Event date: 2000.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  61. Endothelin B receptors modulate hepatic metabolic response in endotoxin primed rats. International conference

    Shock 

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    Event date: 2000.3

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  62. Functional role of endothelin receptor subtype distribution in endotoxemia. International conference

    Shock 

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    Event date: 2000.3

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  63. Effects of fluid resuscitation on the pattern of vascular gene expression during abdominal sepsis. International conference

    Shock 

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    Event date: 2000.3

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  64. Intermittent hypoxia induces vasoregulatory gene expression. International conference

    Shock 

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    Event date: 2000.3

    Language:English   Presentation type:Poster presentation  

  65. LPS-induced imbalanced expression of hepatic vascular stress genes in cirrhosis: mechanism of increased susceptibility to endotoxemia. International conference

    Shock 

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    Event date: 2000.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  66. Neovascularization of hepatic arterioles in partial portal vein ligation induced portal hypertension: a novel mechanism of chronic regulation in hepatic blood flow.

    American Association for the Study of Liver Diseases 

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    Event date: 1999

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  67. Expression and localization of endothelin B receptors in LPS priming. International conference

    Fourth International Shock Congress 

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    Event date: 1999

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  68. Functional significance of endothelin-B receptor expression in endotoxemia. International conference

    Fourth International Shock Congress 

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    Event date: 1999

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  69. Differential expression of vascular stress genes in hepatocellular injury induced by following liver cirrhosis. International conference

    Fourth International Shock Congress 

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    Event date: 1999

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  70. Microheterogeneity of liver PO2 and redox potential in response to endothelin in vivo. International conference

    International Conference of Hepatic and Splanchnic Circulation in Health and Diseases 

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    Event date: 1999

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  71. Effect of Bosentan on hepatic microcirculatory perfusion in rat biliary cirrhosis: evidence for a role of endothelin in hemodynamic abnormalities of liver cirrhosis. International conference

    American Association for the Study of Liver Diseases 

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    Event date: 1999

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  72. Altered Endothelin-B receptor expression and response in hepatic injury after ischemia / reperfusion. International conference

    American Association for the Study of Liver Diseases 

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    Event date: 1999

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  73. Expression of vasoregulatory genes in the liver during progression of liver cirrhosis. International conference

    Baveja R, Bin X, Yokoyama Y, Sonin N, Clemens MG, Zhang J.

    American Association for the Study of Liver Diseases 

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    Event date: 1999

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  74. Microheterogeneity of liver PO2 in response to Endothelin-1: exacerbation by LPS priming.

    Fourth International Shock Congress 

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    Event date: 1999

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  75. Microheterogeneity of liver PO2 and reduced pyridine nucleotide in response to Endothelin in vivo. International conference

    FASEB 

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    Event date: 1999

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  76. Effect of endotoxin on expression of vascular stress genes in liver cirrhosis. International conference

    FASEB 

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    Event date: 1999

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  77. Hepatic enothelin subtype expression in endotoxin treated rat. International conference

    FASEB 

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    Event date: 1999

    Language:English   Presentation type:Poster presentation  

  78. Reciprocal changes in expression of vascular stress genes in hepatic parenchymal and nonparenchymal cells in response to endotoxin. International conference

    Sonin N, Baveja R, Yokayama Y, Zhang J, Clemens MG.

    American Association for the Study of Liver Diseases 

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    Event date: 1998

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  79. Reciprocal changes in expression of vascular stress genes in hepatic parenchymal and nonparenchymal cells in response to endotoxin. International conference

    American Association for the Study of Liver Diseases 

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    Event date: 1998

    Language:English   Presentation type:Poster presentation  

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Research Project for Joint Research, Competitive Funding, etc. 6

  1. 高齢者術後せん妄に対する予防法・治療法の標準化に関する研究

    2015.4 - 2016.3

    科学技術振興調整費 

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    Grant type:Competitive

  2. 高度侵襲手術中に発生するバクテリアルトランスロケーションと腸内フローラの関係

    2014.4 - 2015.3

    ヤクルト・バイオサイエンス研究財団 

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    Grant type:Competitive

  3. 高齢者術後せん妄に対する予防法・治療法の標準化に関する研究

    2011.4

    厚生労働省長寿医療研究開発費 

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    Grant type:Competitive

  4. Nek2 siRNAと抗癌剤併用時のシグナル伝達系に関する基礎的研究

    2009.4 - 2010.3

    財団法人愛知県がん研究振興会 

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    Grant type:Competitive

  5. 胆膵領域癌に対するTLK1を標的とした新規分子標的治療法の開発

    2008.4 - 2009.3

    上原記念生命科学財団 

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    Grant type:Competitive

  6. 胆道癌肝切除における手術侵襲にともなうbacterial translocationと遺伝子多型に関する研究

    2008.4 - 2009.3

    ヤクルト・バイオサイエンス研究財団 

      More details

    Grant type:Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 37

  1. 肝虚血再潅流障害における分枝鎖アミノ酸の新規分子機構の探索

    2013.7 - 2015.6

    科学研究費補助金  基盤研究(C)

    菅原元

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    Authorship:Coinvestigator(s) 

  2. TLR7アプタマーによる内因性Danger Signalの制御と新規治療法の開発

    2013.7 - 2016.6

    科学研究費補助金  基盤研究(C)

    上原圭介

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    Authorship:Coinvestigator(s) 

  3. 乳癌におけるChromothripsis変異を標的にした新規治療法の開発

    2013.7 - 2016.6

    科学研究費補助金  基盤研究(C)

    角田伸行

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  4. 分子進化の概念に基づく新規遺伝子の探索と機能解析

    2013.4 - 2016.3

    科学研究費補助金 

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  5. 膵癌細胞の早期転移とdormancyに関する機序解明とその治療法の検討

    Grant number:20H03751  2020.4 - 2025.3

    山口 淳平

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    膵癌の根治には手術による切除が必要不可欠であるが、たとえ原発巣を切除し得ても遠隔転移の制御が困難な事がある。膵癌に多い遠隔転移形式は肝転移、肺転移、および腹膜播種であるが、これらは原発巣切除後数年経過してから顕在化することが少なくない。しかし一方では、膵癌細胞はその発生初期に全身に播種をきたすともされる。この原発巣と遠隔転移発生の時期的な不一致性はtumor dormancyとして長年認識されてはいるものの、その原因と機序は未だ明らかではない。本研究の目的は膵癌の早期転移およびそのdormancyにおける機序の解明と、さらには後期遠隔転移発生予防のための新たな治療戦略の開発を目指すことである。

  6. Novel diagnostic methods for invisible pancreas cancer

    Grant number:19K09168  2019.4 - 2022.3

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  7. Novel therapy based on engraftment, asymmetric division and Self-organization of circulating tumor cells

    Grant number:19K09142  2019.4 - 2022.3

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  8. Novel treatment using adipose stem cell for postoperative liver damage

    Grant number:19K09118  2019.4 - 2022.3

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  9. Trefoil Factorと肝発癌の関連および肝癌新規治療法開発に関する研究

    Grant number:19K09141  2019.4 - 2022.3

    江畑 智希

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    TFF(Trefoil Factor Family)には3つのサブタイプが存在するが、それぞれが特徴的な癌抑制作用を有していることが示唆されている。またTFFは分泌型タンパクであり、血中に分泌されホルモンとして作用している可能性がある。この研究の目的は、肝発癌遺伝子改変マウスモデルとTFFノックアウトマウスを用いてTFFによる原発性肝癌抑制作用とその機序を解明し、またTFFに対する受容体を発見し腫瘍免疫への関与を突き止めることであり、さらにはTFFリコンビナントタンパクを用いた新規肝癌治療法を開発することである。
    Trefoil factor family (TFF)は消化管粘膜の再生に寄与するとされてきたが、同時に胃癌に対する癌抑制遺伝子としての機能を兼ね備えているという指摘がある。我々はこれまでの研究で、TFFは膵臓においても癌抑制因子として作用していることを突き止めた。一方、TFFと肝発癌との関連についてはこれまでに報告がないが、組織におけるTFF発現状況を鑑みれば、膵癌とは異なった機序により肝発癌に関与している可能性が高い。本研究の目的は、肝発癌におけるTFFの癌抑制遺伝子としての役割と機序を検討して明らかにすることであり、さらには肝細胞癌およびその他の悪性腫瘍に対する新たな治療戦略を開拓することである。TFFは低分子量の分泌型タンパクであるため、recombinant proteinを利用して将来的な肝細胞癌治療戦略に大きく寄与する可能性がある。
    これまでの研究で、TFF1は肝細胞癌の発生を抑制する作用を有していることが明らかとなった。すなわち、肝細胞癌培養細胞株に対してTFF1発現を導入すると、癌細胞の細胞死(アポトーシス)が増え、増殖が抑制されることが確認された。また肝細胞癌発癌モデルであるKC(Alb-Cre/LSL-KRAS)マウスにおいてTFF1遺伝子をノックアウトすると、肝細胞癌の発生が促進されることが確認された。さらにヒト肝細胞癌のDNAにおいては、エピジェネティックにTFF1の発現が抑制されていることが明らかとなった。つまり肝細胞癌が発生する際には癌抑制遺伝子であるTFF1の発現が抑制されることが示唆される。これらのTFF1による癌抑制作用はrecombinantタンパクによっても同様に導入されることが確認され、今後の肝細胞癌治療戦略において有用であると考えられる。
    TFFには3つのサブタイプが存在する(TFF1,TFF2およびTFF3)。これらはそれぞれに異なる作用機序を有しており、固有の癌抑制効果を持つことが示唆されているが、肝発癌における癌抑制作用はこれまでに報告がなく、詳細は明らかでない。我々の研究により、TFF1には肝細胞癌の発生を抑制する事が明らかとなった。これは、肝細胞癌進展に寄与するとされるWnt/beta-catenin経路を抑制することで引き起こされる現象であることも判明し、学会発表/論文としての発表も終えており、研究課題の進歩状況は順調であると考える。
    しかしながら肝発癌に関係する他の因子についても現在検討中であり、さらなる研究成果の発展が期待される。例えばTFF1による癌抑制作用を実際の肝細胞癌治療に応用できる可能性が高く、現在その方法および効果の予測に関する検討が進行中である。また他のTFFサブタイプ(TFF2)による肝癌抑制作用についての検討は現在進行中であり、マウスを用いた研究結果が待たれるところでもある。さらに、原発性肝癌には肝細胞癌と胆管細胞癌の2種類が広く認識されているが、胆管細胞癌に対するTFFの作用は未確認であり今後の検討課題となる。以上より、研究はおおむね順調に推移しているがまだ多くの課題が残されていると考えられる。
    現在in vivoの研究としてTFF1と同様にKCマウスの肝細胞癌発癌におけるTFF2のノックアウトによる効果を検討中である。一部のKC/TFF2KOでは特殊な組織型の悪性腫瘍の発生が確認されており、TFF2による特異的な癌抑制作用が示唆されている。しかしながらこれらのマウスの肝臓に腫瘍が発生するまでには生後約1年という長期間を要するため、いかに目的遺伝子を持ったマウスを効率的な入手方法、マウスを長期間維持するための飼育方法、さらには新たな発癌因子の追加による短期発癌モデルの開発など、様々な要素についてさらなる検討が必要である。
    in vitroの研究として、TFF2発現プラスミドと胆管癌培養細胞株を用いた検討が進行中である。すでにTFF2による腫瘍抑制効果の一端が明らかとなってはいるものの、その詳細の解明には依然として検討課題が多い。また強制発現モデルと同時にrecombinant proteinを用いた細胞外からの腫瘍抑制効果についてもさらなる検討が必要である。
    これらTFF1およびTFF2の腫瘍抑制効果の詳細が明らかになり次第、次のステップである癌治療への応用方法の検討を予定している。上記のようにKCマウスモデルは発癌に時間がかかるため、治療効果の確認に最適なモデルとは言い難い。よって、マウスに特殊な食事(CDE diet等)を与えることで脂肪肝、肝硬変、および肝細胞癌の導入を図る。このマウスモデルが確立すれば個体にTFFを投与してその発癌抑制効果、腫瘍縮小効果、抗癌剤治療効果などを検討することで、TFFによる肝癌治療応用への扉を開く研究とする予定である。

  10. The role of TFF1 to inhibit the development of pancreatic cancer

    Grant number:17K10695  2017.4 - 2020.3

    Yamaguchi Junpei

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    Trefoil Factor Family 1 is the secreted protein and supposed to be the tumor suppressor in gastric carcinogenesis. We analyzed surgically-resected pancreatic specimen, pancreatic cancer cell line and genetically-engeneered mouse model to investigate the association of TFF1 and pancreatic carcinogenesis. This study revealed that TFF1 inhibits malignant transformation of pancreatic premelignant lesions by controling epithelial-mesenchymal transition (EMT). TFF1 has the potential to be the novel therapeutic strategy for pancreatic cancer.

  11. 術後肝障害に対するTLR4を標的にした予防治療法の開発

    Grant number:17K10667  2017.4 - 2018.3

    菅原 元

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    肝切除術後に発生する肝障害は重篤化することも多く早急に解決しなければいけない課題である。TLR4は免疫反応や炎症の制御に関わる分子であるToll様受容体の1つである。グラム陰性菌の外膜の成分であるリポ多糖(LPS)やグラム陽性菌のペプチドグリカン層にあるリポテイコ酸をリガンドとして認識する受容体である。ラット肝障害モデルへのTLR4阻害剤投与は肝機能を改善させ、肝障害を軽減させる傾向があった。一方で細胞株に対するTLR4阻害剤の研究において、TLR4阻害剤には細胞の増殖抑制効果を認めた。
    これまでの肝再生に関する研究において、肝障害時にTFF1(trefoil factor family1)の発現に変化が生じており、TFF1(trefoil factor family1)と胆管再生の関連性が示唆されている。われわれはTFF1(trefoil factor family1)をノックアウトしたマウスを作成しており、このTFF1をノックアウトしたマウスを用いてラット肝虚血・再潅流モデル、ラット胆管結紮による閉塞性黄疸モデル、CCl4(四塩化炭素)によるラット肝硬変モデルを作製した。ラット胆管結紮による閉塞性黄疸モデルでは、術後早期に死亡しており、正常マウス群と比較してTFF1のノックアウトマウス群での死亡率が高かった。また病理学的検討によりTFF1のノックアウトマウス群において胆管新生に抑制傾向を認めた。さらにTFF1のノックアウトマウス群の肝臓では有意に壊死組織の面積が多かった。CCl4(四塩化炭素)によるラット肝硬変モデルにおいて3か月の経過観察をおこなっているが、正常マウス群と比較して死亡率に関して特に差を認めなかった。

  12. Novel strategies to target the premetastatic niche for cancer metastasis

    Grant number:16K10568  2016.4 - 2019.3

    MIZUNO TAKASHI

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    TPX2 was highly expressed in pancreatic cancer cell lines (PANC1 and KLM1) and colon cancer cell lines (DLD1 and HCT15). A TPX2 siRNA induced the TPX2 suppression and MCP1 overexpression in PANC1 and KLM1 cells. The culture medium of TPX2 siRNA-transfected pancreatic cancer cells showed an inhibitory effect on the proliferation and invasion of cancer cells. Factors secreted by TPX2 siRNA-transfected pancreatic cancer cells may cause a secondary effect on pancreatic cancer.
    Pre-exposure to 5-FU significantly enhanced its anticancer effect on the proliferation of KLM1, KP4 and DLD1 cells. However, there were no significant differences in the motility and invasion between cells that were and were not pre-exposed to 5-FU. The secondary effect was not simple and uniform in terms of cancer cell damage. Further investigations will be required for clinical applications. However, our data indicate the potential for a new therapy using TPX2 siRNA to improve the cancer prognosis.

  13. Novel strategies for cancer stem cells

    Grant number:16K10454  2016.4 - 2019.3

    TSUNODA NOBUYUKI

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    Proliferation was activated in c-Met-positive cholangiocarcinoma cells compared with that in c-Met-negative cholangiocarcinoma cells. Cell viability was suppressed in c-Met-positive and CD49f-positive cholangiocarcinoma cells. Cell growth was more highly activated in CD133-positive colorectal cancer cells than in CD133-negative colorectal cancer cells.
    Next-generation sequencing revealed 938 candidate fusion genes in cancer cells. LOC646214, which is a p21 protein (Cdc42/Rac)-activated kinase 2 pseudogene, formed fusions with many genes.
    In addition, long intergenic/intervening noncoding RNA (LINC) formed fusions with many genes. Because these fusion genes do not synthesize proteins, antibody medicines were not effective against these genes. From this viewpoint, these fusion genes were thought to be the best targets for nucleic acid medicines.

  14. Mechanism of action of a bisabolol derivative and its clinical application

    Grant number:16K10591  2016.4 - 2019.3

    KOKURYO TOSHIO

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    Bisabolol derivative suppressed proliferation, motility and invasion and induced cell death in human pancreatic cancer cell lines. Gene analysis revealed that the expression of focal adhesion kinase (FAK) in cancer cell lines was decreased by bisabolol treatment. In addition, bisabolol derivative and bisabolol significantly inhibited the tumor growth in a mouse xenograft tumor model. Bisabolol demonstrated a similar antitumor effect to that of gemcitabine upon application of a novel drug delivery system using capsules. Although bisabolol was measured in rat blood using a mass spectrograph, the pharmacokinetics of the drug was not evaluated. Further investigations will be required for clinical applications. However, this study suggests that novel therapies using bisabolol for treating refractory cancer could be efficacious.

  15. Analysis of the inhibitory effect of cysteine on liver damage

    Grant number:16K10567  2016.4 - 2019.3

    YOKOYAMA YUKIHIRO

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    Cysteine suppressed the shrinkage of hepatic stellate cells and strongly inhibited the endothelin-induced elevation of calcium in hepatic stellate cells. The serum ALT level in the cysteine-administered group was significantly lower than that in the non-administered group in a rat sepsis model. Cysteine showed an inhibitory effect on rat liver damage caused by intraperitoneal administration of lipopolysaccharide (LPS). The serum albumin level was correlated with the area of the psoas major muscle. The hospitalization period was prolonged, and postoperative complications such as an abdominal abscess and liver failure increased in patients with decreased muscle mass (sarcopenia) of the total femoral muscle. Most covalent bonds in cysteine were formed with serum albumin. Our results suggested that cysteine was effective in improving sarcopenia after surgery.

  16. Mechanism of a new cancer treatment targeting TLR7

    Grant number:16K10531  2016.4 - 2019.3

    UEHARA KEISUKE

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    Imiquimod, a TLR7 agonist, suppressed proliferation, motility and invasion and induced cell death in a human cancer cell line (DLD1, KLM1, Panc1 and HuCCT1). The cell morphology was different in each cancer cell line after imiquimod treatment. In addition, imiquimod induced early apoptosis in the cancer cell lines after 12 hours of treatment. Immunoglobulin heavy chain-binding protein (BiP), which is a marker of endoplasmic reticulum stress, was highly expressed in cancer cells after imiquimod treatment. Therefore, endoplasmic reticulum stress was considered a cause of imiquimod-induced apoptosis. However, the expression of PKR-like ER kinase (PERK), which is another marker of endoplasmic reticulum stress, did not change. This result suggested that a mechanism different from endoplasmic reticulum stress was involved in imiquimod-induced apoptosis. Further investigations will be required for clinical applications.

  17. Novel strategies targeting RAGE for postoperative infectious complications

    Grant number:15K10092  2015.4 - 2018.3

    FUKAYA MASAHIDE

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    Severe liver damage was identified in rats with bile duct ligation and liver ischemia re-perfusion. RAGE (Receptor for advanced glycation end products) was highly expressed in these rats. TAK242, a TLR4 inhibitor, suppressed the elevation of serum ALT and AST in the rats with bile duct ligation and liver ischemia re-perfusion. In addition, TAK242 treatment decreased the area of hepatic necrosis and suppressed the expression of IL-1β, IL-6 and HMGB1. TAK242 significantly improved the severity of the liver damage caused by bile duct ligation and liver ischemia re-perfusion. However, the compound was not able to significantly suppress RAGE expression. In addition, bisabolol did not demonstrate an inhibitory effect against RAGE in rats with bile duct ligation and liver ischemia re-perfusion. Further investigations will be required for clinical applications. However, this study suggests that novel therapies using TAK242 for treating severe liver damage could be efficacious.

  18. 分子進化の概念に基づく新規遺伝子の探索と機能解析

    2013.7 - 2016.6

    科学研究費補助金 

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    Authorship:Principal investigator 

  19. 新規セリンスレオニンキナーゼ阻害剤による胆管 癌・膵癌治療法の開発

    2012.7 - 2016.6

    科学研究費補助金  基盤研究(B)

    梛野正人

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  20. 膵癌における新規治療抵抗性遺伝子の探索とその阻害剤による治療法の開発

    2012.7 - 2015.6

    科学研究費補助金  基盤研究(C)

    國料俊男

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  21. 肝切除時におけるリアルタイム肝機能モニタリングシステムの開発と臨床応用

    2012.7 - 2014.6

    科学研究費補助金 

    梛野正人

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  22. 化学療法関連肝障害の外科手術への影響とその病態生理の解明

    2012.7 - 2013.6

    科学研究費補助金  基盤研究(C)

    吉岡裕一郎

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  23. 癌における細胞老化関連遺伝子の探索と臨床応用

    2011.7 - 2014.6

    科学研究費補助金  基盤研究(C)

    伊神剛

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  24. 食道癌に対する相互マシンラーニング法によるHedgehog新規阻害剤の開発

    2011.7 - 2014.6

    科学研究費補助金  基盤研究(C)

    深谷昌秀

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  25. 微小転移における網羅的遺伝子解析とその結果に基づく新規癌転移抑制療法の開発

    2010.7 - 2012.6

    科学研究費補助金  基盤研究(C)

    角田伸行

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  26. 大腸癌 microscopic abscess における網羅的遺伝子解析とその結果に基づく新規癌転移抑制療法の開発

    2010.7 - 2012.6

    科学研究費補助金  基盤研究(C)

    上原圭介

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  27. GGTトランスジェニックマウスを用いた肝虚血/再潅流障害メカニズムの解明

    2009.7 - 2011.6

    科学研究費補助金  基盤研究(C)

    菅原元

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  28. Nek2を標的にした包括的癌治療法の開発とそのトランスレーショナルリサーチ

    2008.7 - 2012.6

    科学研究費補助金  基盤研究(A)

    二村雄次

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  29. 肝再生におけるカルシトニンの役割とその分子機構

    2008.7 - 2010.6

    科学研究費補助金  基盤研究(C)

    横山幸浩

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    Authorship:Principal investigator 

  30. 急性胆管閉塞にともなう肝障害におけるPPARgammaの役割について

    2008.7 - 2010.6

    科学研究費補助金  基盤研究(C)

    伊神剛

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  31. 複数の癌特異的遺伝子を標的にした分子標的治療の開発

    2008.7 - 2010.6

    科学研究費補助金  基盤研究(C)

    國料俊男

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  32. 肝門部胆管癌からの胆管癌幹細胞の分離と網羅的遺伝子解析に基づく分子標的治療の開発

    2007.7 - 2010.6

    科学研究費補助金  基盤研究(B)

    梛野正人

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    胆管癌より癌幹細胞を分離しこれに網羅的遺伝子解析を施行、癌特異遺伝子を同定し、分子標的治療を開発する。

  33. 慢性腎不全下における肝切除後肝再生のメカニズムについて

    2007.7 - 2009.6

    科学研究費補助金  基盤研究(C)

    西尾秀樹

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  34. 胆道癌におけるHegdehogシグナル系の発現解析

    2007.7 - 2009.6

    科学研究費補助金  基盤研究(C)

    深谷昌秀

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  35. 胆管閉塞時にみられるパイエル板萎縮のメカニズムについて

    2006.7 - 2007.6

    科学研究費補助金  基盤研究(C)

    横山幸浩

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    Authorship:Principal investigator 

  36. 血管内皮伸展刺激に着目した肝再生メカニズムに関する基礎実験的研究

    2005.7 - 2007.6

    科学研究費補助金  基盤研究(C)

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  37. 胆管細胞癌の網羅的遺伝子解析とそれに基づく分子標的制癌療法の開発

    2004.7 - 2007.6

    科学研究費補助金  基盤研究(A)

    二村雄次

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Industrial property rights 4

  1. 膵液漏の予防及び治療

    國料俊男、横山幸浩、山本徳則、柴田玲

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    Application no:特願 2014-147173  Date applied:2014.7

    Country of applicant:Domestic  

  2. 内毒素による臓器不全予防剤

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