Updated on 2024/04/02

写真a

 
MARUYAMA, Shoichi
 
Organization
Graduate School of Medicine Program in Integrated Medicine Internal Medicine Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Professor
Contact information
メールアドレス

Degree 1

  1. 医学博士 ( 1997.3   名古屋大学 ) 

Research Interests 5

  1. membranous nephropathy

  2. adipose derived cell

  3. regenerative medicine

  4. Nephrotic syndrome

  5. Glomerulonephritis

Research Areas 1

  1. Others / Others  / Kidney Internal Medicine

Current Research Project and SDGs 2

  1. Cell therapy usigng adipose tissue derived cells

  2. Diagnosis and treatment of nephrotic syndrome

Research History 5

  1. Nagoya University   Graduate School of Medicine Program in Integrated Medicine Internal Medicine   Professor

    2016.4

  2. Nagoya University   Innovative Research Center for Preventive Medical Engineering   Professor

    2016.4

  3. Associate Professor

    2011.4 - 2016.3

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    Country:Japan

  4. associate professor

    2005.11

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    Country:Japan

  5. assistant professor

    2003.6 - 2005.10

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    Country:Japan

Education 2

  1. Nagoya University   Graduate School, Division of Medicine   nephrology

    1993.4 - 1997.3

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    1983.4 - 1989.3

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    Country: Japan

Professional Memberships 9

  1. Japanese Society of Nephrology

  2. The International Society of Nephrology

  3. American Society of Nephrology

  4. Japan Diabetes Society

  5. Japan College of Rheumatology

  6. The Japanese Society of Internal Medicine

  7. Japanese Society for dialysis therapy

  8. (米国)国立腎臓財団

  9. ヨーロッパ腎臓-透析・移植学会

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Committee Memberships 1

  1. Japanese Society of Nephrology   board of directors  

    2020.6   

 

Papers 362

  1. Relationship between peak aortic jet velocity and progression of aortic stenosis in patients undergoing hemodialysis. Reviewed

    Kurasawa S, Imaizumi T, Kondo T, Hishida M, Okazaki M, Nishibori N, Takeda Y, Kasuga H, Maruyama S

    International journal of cardiology   Vol. 402   page: 131822   2024.5

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijcard.2024.131822

    PubMed

  2. Association of serum magnesium levels with renal prognosis in patients with chronic kidney disease.

    Kishi S, Nakashima T, Goto T, Nagasu H, Brooks CR, Okada H, Tamura K, Nakano T, Narita I, Maruyama S, Yano Y, Yokoo T, Wada T, Wada J, Nangaku M, Kashihara N

    Clinical and experimental nephrology     2024.3

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    Language:English  

    DOI: 10.1007/s10157-024-02486-7

    PubMed

  3. Case report: A family of atypical hemolytic uremic syndrome involving a <i>CFH::CFHR1</i> fusion gene and <i>CFHR3-1-4-2</i> gene duplication

    Tasaki, Y; Tsujimoto, H; Yokoyama, T; Sugimoto, N; Kitajima, S; Fujii, H; Hidaka, Y; Kato, N; Maruyama, S; Inoue, N; Wada, T

    FRONTIERS IN IMMUNOLOGY   Vol. 15   page: 1360855   2024.3

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  4. Association between stopping renin-angiotensin system inhibitors immediately before hemodialysis initiation and subsequent cardiovascular events Reviewed

    Nakamura, Y; Inaguma, D; Imaizumi, T; Kurasawa, S; Hishida, M; Okazaki, M; Fujishima, Y; Nishibori, N; Suzuki, K; Takeda, Y; Maruyama, S

    HYPERTENSION RESEARCH     2024.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41440-024-01616-8

    Web of Science

    PubMed

  5. Detecting and exploring kidney-derived extracellular vesicles in plasma Reviewed

    Komatsu, S; Kato, N; Kitai, H; Funahashi, Y; Noda, Y; Tsubota, S; Tanaka, A; Sato, Y; Maeda, K; Saito, S; Furuhashi, K; Ishimoto, T; Kosugi, T; Maruyama, S; Kadomatsu, K

    CLINICAL AND EXPERIMENTAL NEPHROLOGY     2024.3

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  6. Deterministic sampling method using simplex ensemble and scaling method for efficient and robust uncertainty quantification

    Endo, T; Maruyama, S; Yamamoto, A

    JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY   Vol. 61 ( 3 ) page: 363 - 374   2024.3

  7. Population characteristics and diagnosis rate of chronic kidney disease by eGFR and proteinuria in Japanese clinical practice: an observational database study

    Tanaka, T; Maruyama, S; Chishima, N; Akiyama, H; Shimamoto, K; Inokuchi, S; Yokota, K; Ozaki, A

    SCIENTIFIC REPORTS   Vol. 14 ( 1 ) page: 5172   2024.3

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  8. Changes in antibody titer after four and five doses of the SARS-CoV-2 vaccine in Japanese post-kidney transplant patients

    Fujieda, K; Tanaka, A; Kikuchi, R; Takai, N; Saito, S; Yasuda, Y; Sano, Y; Kato, M; Furuhashi, K; Maruyama, S

    THERAPEUTIC APHERESIS AND DIALYSIS     2024.2

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  9. A case of late-onset organizing pneumonia following COVID-19 infection in a post-kidney transplant patient

    Fujieda, K; Saito, S; Tanaka, A; Furuhashi, K; Yasuda, Y; Sano, Y; Kato, M; Maruyama, S

    CEN CASE REPORTS     2024.2

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  10. Macrophage-1 antigen exacerbates histone-induced acute lung injury and promotes neutrophil extracellular trap formation

    Mizuno, T; Nagano, F; Takahashi, K; Yamada, S; Fruhashi, K; Maruyama, S; Tsuboi, N

    FEBS OPEN BIO     2024.2

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  11. Mortality and hyperkalaemia-associated hospitalisation in patients with chronic kidney disease: comparison of sodium zirconium cyclosilicate and sodium/calcium polystyrene sulfonate

    Onogi, C; Watanabe, Y; Tanaka, A; Furuhashi, K; Maruyama, S

    CLINICAL KIDNEY JOURNAL   Vol. 17 ( 2 ) page: sfae021   2024.2

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  12. Clinical characteristics of anti-GBM disease with thrombotic microangiopathy: a case report and literature review

    Nakamura, Y; Kato, N; Tatematsu, Y; Arai, Y; Mori, N; Shibata, K; Yamazaki, M; Yasui, H; Fujiwara, S; Yamakawa, T; Maruyama, S

    CEN CASE REPORTS   Vol. 13 ( 1 ) page: 37 - 44   2024.2

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  13. Establishment of an adverse effect prevention protocol on plasma exchange using fresh frozen plasma prior to ABO-incompatible living donor kidney transplantation at our hospital

    Tanaka, A; Watanabe, Y; Furuhashi, K; Saito, S; Yasuda, Y; Kosugi, T; Sano, Y; Kato, M; Maruyama, S

    THERAPEUTIC APHERESIS AND DIALYSIS   Vol. 28 ( 1 ) page: 152 - 157   2024.2

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  14. Rationale and design of the Japanese Biomarkers in Nephrotic Syndrome (J-MARINE) study

    Kurasawa, S; Kato, S; Ozeki, T; Akiyama, S; Ishimoto, T; Mizuno, M; Tsuboi, N; Kato, N; Kosugi, T; Maruyama, S

    CLINICAL AND EXPERIMENTAL NEPHROLOGY     2024.1

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  15. Clinicopathological prognostic stratification for proteinuria and kidney survival in IgA nephropathy: a Japanese prospective cohort study

    Koike, K; Kawamura, T; Hirano, K; Nishikawa, M; Shimizu, A; Joh, K; Katafuchi, R; Hashiguchi, A; Yano, Y; Matsuzaki, K; Matsushima, M; Tsuboi, N; Maruyama, S; Narita, I; Yokoo, T; Suzuki, Y

    CLINICAL KIDNEY JOURNAL   Vol. 17 ( 1 ) page: sfad294   2024.1

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  16. Uncertainty reduction of sodium void reactivity using data from a sodium shielding experiment

    Maruyama, S; Endo, T; Yamamoto, A

    JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY   Vol. 61 ( 1 ) page: 31 - 43   2024.1

  17. Compton Imaging Using Pixelated TlBr Semiconductor Detector

    Hitomi, K; Matsumura, M; Watanabe, K; Maruyama, S; Nogami, M; Akira, U

    SENSORS AND MATERIALS   Vol. 36 ( 1 )   2024

  18. Impact of an angulated aorto-septal relationship on cardio-cerebrovascular outcomes in patients undergoing hemodialysis.

    Nakayama T, Yamamoto J, Ozeki T, Tokoroyama S, Mori Y, Hori M, Tsujita M, Shirasawa Y, Takeda A, Kondo C, Murata M, Suzuki S, Kinoshita Y, Fukuda M, Ueki T, Ikehara N, Sugiura M, Goto T, Hashimoto H, Yajima K, Maruyama S, Koyama H, Morozumi K, Seo Y

    PloS one   Vol. 19 ( 2 ) page: e0298637   2024

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    Language:English  

    DOI: 10.1371/journal.pone.0298637

    PubMed

  19. Complement terminal pathway inhibition reduces peritoneal injuries in a rat peritonitis model

    Kamegai, N; Kim, H; Suzuki, Y; Fukui, S; Kojima, H; Maruyama, S; Morgan, BP; Zelek, WM; Mizuno, M

    CLINICAL AND EXPERIMENTAL IMMUNOLOGY   Vol. 214 ( 2 ) page: 209 - 218   2023.12

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  20. Coexistence of low muscle mass and osteoporosis as a predictor of fragility fractures in long-term kidney transplant recipients

    Hori, M; Takahashi, H; Kondo, C; Matsuoka, Y; Tsujita, M; Nishihira, M; Uchida, K; Takeda, A; Morozumi, K; Maruyama, S

    AMERICAN JOURNAL OF NEPHROLOGY   Vol. 54 ( 11-12 ) page: 489 - 497   2023.12

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  21. Current status of low-density lipoprotein apheresis treatment for patients with peripheral artery disease and chronic kidney disease in Japanese clinical database

    Watanabe, Y; Tanaka, A; Furuhashi, K; Maruyama, S

    THERAPEUTIC APHERESIS AND DIALYSIS   Vol. 27 ( 6 ) page: 1000 - 1009   2023.12

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  22. Association between serum iron markers, iron supplementation and cardiovascular morbidity in pre-dialysis chronic kidney disease.

    Hasegawa T, Imaizumi T, Hamano T, Murotani K, Fujii N, Komaba H, Ando M, Maruyama S, Nangaku M, Nitta K, Hirakata H, Isaka Y, Wada T, Fukagawa M

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   Vol. 38 ( 12 ) page: 2713 - 2722   2023.11

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    Language:English  

    DOI: 10.1093/ndt/gfad096

    PubMed

  23. 特集 血液浄化法に応じた食と栄養 4.長時間血液透析(2)今日から実践可能な,透析患者の低栄養への根本的対策

    菱田 学, 岡崎 雅樹, 西堀 暢浩, 今泉 貴広, 金田 史香, 丸山 彰一

    臨床透析   Vol. 39 ( 12 ) page: 1397 - 1404   2023.11

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    Publisher:日本メディカルセンター  

    DOI: 10.19020/cd.0000002767

    CiNii Research

  24. Overlapping Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy with Mutation in <i>CFI</i> in a Japanese Patient: A Case Report

    Osawa Kosuke, Yamamoto Shuto, Yamano Yukiko, Kita Ayako, Okamoto Kota, Kato Noritoshi, Tatematsu Yoshitaka, Kojima Fumiyoshi, Ohya Masaki, Hara Shigeo, Murata Shin-ichi, Inoue Norimitsu, Maruyama Shoichi, Araki Shin-ichi

    Internal Medicine   Vol. advpub ( 0 )   2023.11

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    Language:English   Publisher:The Japanese Society of Internal Medicine  

    <p>A 34-year-old Japanese man presented with blurred vision, headache, nausea, anemia, thrombocytopenia, and severe renal dysfunction. Thrombotic microangiopathy was initially suspected to have been caused by malignant hypertension. Antihypertensive medications did not improve his thrombocytopenia or renal dysfunction, and other diseases causing thrombotic microangiopathy were ruled out. Therefore, the patient was diagnosed with atypical hemolytic uremic syndrome. A renal biopsy revealed an overlap of thrombotic microangiopathy and C3 glomerulopathy. Genetic testing revealed c.848A>G (p.Asp283Gly), a missense heterozygous variant in the gene encoding complement factor I. Overlapping atypical hemolytic uremic syndrome and C3 glomerulopathy with complement factor I mutation is very rare, especially in Japan. </p>

    DOI: 10.2169/internalmedicine.2713-23

    PubMed

    CiNii Research

  25. An estimation method for an unknown covariance in cross-section adjustment based on unbiased and consistent estimator

    Maruyama, S; Endo, T; Yamamoto, A

    JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY   Vol. 60 ( 11 ) page: 1372 - 1385   2023.11

  26. Basigin is released in extracellular vesicles derived from the renal tubular epithelium in response to albuminuria

    Watanabe, T; Maeda, K; Kato, N; Seko, H; Sugimura, M; Sato, Y; Ryuge, A; Kato, S; Kadomatsu, K; Maruyama, S; Kosugi, T

    NEPHROLOGY   Vol. 28 ( 11 ) page: 629 - 638   2023.11

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  27. Mesenchymal stem/stromal cells generated from induced pluripotent stem cells are highly resistant to senescence

    Aoi, T; Tanaka, A; Furuhashi, K; Ikeya, M; Shimizu, A; Arioka, Y; Kushima, I; Ozaki, N; Maruyama, S

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 85 ( 4 ) page: 682 - 690   2023.11

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  28. Relationship between the lower limit of systolic blood pressure target and kidney function decline in advanced chronic kidney disease: an instrumental variable analysis from the REACH-J CKD cohort study

    Kurasawa, S; Yasuda, Y; Kato, S; Maruyama, S; Okada, H; Kashihara, N; Narita, I; Wada, T; Yamagata, K

    HYPERTENSION RESEARCH   Vol. 46 ( 11 ) page: 2478 - 2487   2023.11

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  29. Associations of corticosteroid therapy and tonsillectomy with kidney survival in a multicenter prospective study for IgA nephropathy

    Kawamura, T; Hirano, K; Koike, K; Nishikawa, M; Shimizu, A; Joh, K; Katafuchi, R; Hashiguchi, A; Matsuzaki, K; Maruyama, S; Tsuboi, N; Narita, I; Yano, Y; Yokoo, T; Suzuki, Y

    SCIENTIFIC REPORTS   Vol. 13 ( 1 ) page: 18455   2023.10

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  30. Novel function of transglutaminase 2 in extracellular histone-induced acute lung injury

    Mizuno, T; Nagano, F; Ito, Y; Tatsukawa, H; Shinoda, Y; Takeuchi, T; Takahashi, K; Tsuboi, N; Nagamatsu, T; Yamada, S; Maruyama, S; Hitomi, K

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 678   page: 179 - 185   2023.10

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  31. Real-world safety profile of eculizumab in patients with paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, or generalized myasthenia gravis: an integrated analysis of post-marketing surveillance in Japan

    Nishimura, JI; Kawaguchi, T; Ito, S; Murai, H; Shimono, A; Matsuda, T; Fukamizu, Y; Akiyama, H; Hayashi, H; Nakano, T; Maruyama, S

    INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 118 ( 4 ) page: 419 - 431   2023.10

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  32. Importance of education on steroid cover: a case of hyponatremia after dental extraction with local anesthesia in a patient with idiopathic hypopituitarism

    Nakamura, Y; Saito, S; Okada, N; Yamakawa, T; Maruyama, S

    CEN CASE REPORTS     2023.9

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  33. The association of low serum magnesium levels with frailty among hemodialysis patients

    Hori, M; Yasuda, K; Takahashi, H; Morozumi, K; Maruyama, S

    SCIENTIFIC REPORTS   Vol. 13 ( 1 ) page: 14982   2023.9

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  34. Higher hemoglobin levels using darbepoetin alfa and kidney outcomes in advanced chronic kidney disease without diabetes: a prespecified secondary analysis of the PREDICT trial

    Maruyama, S; Kurasawa, S; Hayashi, T; Nangaku, M; Narita, I; Hirakata, H; Tanabe, K; Morita, S; Tsubakihara, Y; Imai, E; Akizawa, T; PREDICT Investigators

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 27 ( 9 ) page: 757 - 766   2023.9

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  35. Prevention of terminal pathway activation improves survival in a lethal malarial infection mouse model associated with multiple organ failure

    Mizuzo, M; Kamiya, T; Miyasaka, Y; Kim, H; Fukui, S; Ishigami, M; Suzuki, Y; Maruyama, S; Ohno, T; Hughes, T; Morgan, BP

    IMMUNOBIOLOGY   Vol. 228 ( 5 ) page: 3 - 3   2023.9

  36. Introduction

    Kanetsuna, Y; Maruyama, S

    NEPHRON   Vol. 147 Suppl 1   page: 5   2023.8

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  37. Association of kidney function with cancer incidence and its influence on cancer risk of smoking: The Japan Multi-Institutional Collaborative Cohort Study

    Kurasawa, S; Imaizumi, T; Maruyama, S; Tanaka, K; Kubo, Y; Nagayoshi, M; Ikezaki, H; Suzuki, S; Koyama, T; Koriyama, C; Kadota, A; Katsuura-Kamano, S; Kuriki, K; Wakai, K; Matsuo, K

    INTERNATIONAL JOURNAL OF CANCER   Vol. 153 ( 4 ) page: 732 - 741   2023.8

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  38. Proliferative glomerulonephritis with monoclonal immunoglobulin deposits and atypical pathological findings treated with corticosteroid and rituximab

    Mori, M; Tanaka, A; Maeda, K; Saito, S; Furuhashi, K; Maruyama, S

    CEN CASE REPORTS   Vol. 13 ( 2 ) page: 128 - 134   2023.8

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  39. Rationale and study design of a randomized controlled trial to investigate the renoprotective effect of canagliflozin assessed by test of renal hemodynamics in diabetic kidney disease (the FAGOTTO study)

    Kato, S; Kuwatsuka, Y; Ando, M; Tatematsu, Y; Nishibori, N; Maruyama, S

    BMC NEPHROLOGY   Vol. 24 ( 1 ) page: 228   2023.8

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  40. IgA-dominant glomerulonephritis with DNAJB9-negative fibrillar polytypic immunoglobulin deposits in the subepithelium

    Muto, R; Maeda, K; Fukui, S; Saito, S; Kato, N; Kosugi, T; Shimizu, A; Maruyama, S

    CEN CASE REPORTS   Vol. 12 ( 3 ) page: 323 - 328   2023.8

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  41. Clinical Course of Adult FSGS and Minimal Change Disease in North American and Japanese Cohorts

    Ozeki, T; Gillespie, BW; Larkina, M; Maruyama, S; Alakwaa, F; Kretzler, M; Mariani, LH

    KIDNEY360   Vol. 4 ( 7 ) page: 924 - 934   2023.7

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  42. Number of calcified aortic valve leaflets: natural history and prognostic value in patients undergoing haemodialysis

    Kurasawa, S; Okazaki, M; Imaizumi, T; Kondo, T; Hishida, M; Nishibori, N; Takeda, Y; Kasuga, H; Maruyama, S

    EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING   Vol. 24 ( 7 ) page: 909 - 920   2023.6

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  43. Profiling of kidney involvement in systemic lupus erythematosus by deep learning using the National Database of Designated Incurable Diseases of Japan

    Kimura, T; Ikeuchi, H; Yoshino, M; Sakate, R; Maruyama, S; Narita, I; Hiromura, K

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 27 ( 6 ) page: 519 - 527   2023.6

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  44. Relapse of atypical hemolytic uremic syndrome triggered by COVID-19: a lesson for the clinical nephrologist

    Uwatoko, R; Shindo, M; Hashimoto, N; Iio, R; Ueda, Y; Tatematsu, Y; Kato, N; Maruyama, S; Hayashi, T

    JOURNAL OF NEPHROLOGY   Vol. 36 ( 5 ) page: 1439 - 1442   2023.6

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  45. MIXED COMMUTATOR LENGTHS, WREATH PRODUCTS AND GENERAL RANKS

    Kawasaki, M; Kimura, M; Maruyama, S; Matsushita, T; Mimura, M

    KODAI MATHEMATICAL JOURNAL   Vol. 46 ( 2 ) page: 145 - 183   2023.6

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  46. Peritoneal Expression of Membrane Complement Regulators Is Decreased in Peritoneal Dialysis Patients with Infected Peritonitis

    Fukui, S; Mizuno, M; Tawada, M; Suzuki, Y; Kojima, H; Matsukawa, Y; Imai, M; Kim, H; Kinashi, H; Mizutani, M; Minoshima, K; Maruyama, S; Ito, Y

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 24 ( 11 )   2023.5

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  47. Prognosis and incidence of infections in chronic kidney disease patients with membranous nephropathy enrolled in a large Japanese clinical claims database

    Matsuzaki, T; Watanabe, Y; Tanaka, A; Furuhashi, K; Saito, S; Maruyama, S

    BMC NEPHROLOGY   Vol. 24 ( 1 ) page: 126   2023.5

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  48. Excess risk of cardiovascular events in patients in the United States vs. Japan with chronic kidney disease is mediated mainly by left ventricular structure and function

    Imaizumi, T; Fujii, N; Hamano, T; Yang, W; Taguri, M; Kansal, M; Mehta, R; Shafi, T; Taliercio, J; Go, A; Rao, PDRA; Hamm, LL; Deo, R; Maruyama, S; Fukagawa, M; Feldman, HI

    KIDNEY INTERNATIONAL   Vol. 103 ( 5 ) page: 949 - 961   2023.5

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  49. Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

    Edahiro, R; Shirai, Y; Takeshima, Y; Sakakibara, S; Yamaguchi, Y; Murakami, T; Morita, T; Kato, Y; Liu, YC; Motooka, D; Naito, Y; Takuwa, A; Sugihara, F; Tanaka, K; Wing, JB; Sonehara, K; Tomofuji, Y; Namkoong, H; Tanaka, H; Lee, H; Fukunaga, K; Hirata, H; Takeda, Y; Okuzaki, D; Kumanogoh, A; Okada, Y; Wang, QBS; Edahiro, R; Namkoong, H; Hasegawa, T; Shirai, Y; Sonehara, K; Tanaka, H; Lee, H; Saiki, R; Hyugaji, T; Shimizu, E; Katayama, K; Kanai, M; Naito, T; Sasa, N; Yamamoto, K; Kato, Y; Morita, T; Takahashi, K; Harada, N; Naito, T; Hiki, M; Matsushita, Y; Takagi, H; Ichikawa, M; Nakamura, A; Harada, S; Sandhu, Y; Kabata, H; Masaki, K; Kamata, H; Ikemura, S; Chubachi, S; Okamori, S; Terai, H; Morita, A; Asakura, T; Sasaki, J; Morisaki, H; Uwamino, Y; Nanki, K; Uchida, S; Uno, S; Nishimura, T; Ishiguro, T; Isono, T; Shibata, S; Matsui, Y; Hosoda, C; Takano, K; Nishida, T; Kobayashi, Y; Takaku, Y; Takayanagi, N; Ueda, S; Tada, A; Miyawaki, M; Yamamoto, M; Yoshida, E; Hayashi, R; Nagasaka, T; Arai, S; Kaneko, Y; Sasaki, K; Tagaya, E; Kawana, M; Arimura, K; Takahashi, K; Anzai, T; Ito, S; Endo, A; Uchimura, Y; Miyazaki, Y; Honda, T; Tateishi, T; Tohda, S; Ichimura, N; Sonobe, K; Sassa, CT; Nakajima, J; Nakano, Y; Nakajima, Y; Anan, R; Arai, R; Kurihara, Y; Harada, Y; Nishio, K; Ueda, T; Azuma, M; Saito, R; Sado, T; Miyazaki, Y; Sato, R; Haruta, Y; Nagasaki, T; Yasui, Y; Hasegawa, Y; Mutoh, Y; Kimura, T; Sato, T; Takei, R; Hagimoto, S; Noguchi, Y; Yamano, Y; Sasano, H; Ota, S; Nakamori, Y; Yoshiya, K; Saito, F; Yoshihara, T; Wada, D; Iwamura, H; Kanayama, S; Maruyama, S; Yoshiyama, T; Ohta, K; Kokuto, H; Ogata, H; Tanaka, Y; Arakawa, K; Shimoda, M; Osawa, T; Tateno, H; Hase, I; Yoshida, S; Suzuki, S; Kawada, M; Horinouchi, H; Saito, F; Mitamura, K; Hagihara, M; Ochi, J; Uchida, T; Baba, R; Arai, D; Ogura, T; Takahashi, H; Hagiwara, S; Nagao, G; Konishi, S; Nakachi, I; Murakami, K; Yamada, M; Sugiura, H; Sano, H; Matsumoto, S; Kimura, N; Ono, Y; Baba, H; Suzuki, Y; Nakayama, S; Masuzawa, K; Namba, S; Shiroyama, T; Noda, Y; Niitsu, T; Adachi, Y; Enomoto, T; Amiya, S; Hara, R; Yamaguchi, Y; Murakami, T; Kuge, T; Matsumoto, K; Yamamoto, Y; Yamamoto, M; Yoneda, M; Tomono, K; Kato, K; Hirata, H; Takeda, Y; Koh, H; Manabe, T; Funatsu, Y; Ito, F; Fukui, T; Shinozuka, K; Kohashi, S; Miyazaki, M; Shoko, T; Kojima, M; Adachi, T; Ishikawa, M; Takahashi, K; Inoue, T; Hirano, T; Kobayashi, K; Takaoka, H; Watanabe, K; Miyazawa, N; Kimura, Y; Sado, R; Sugimoto, H; Kamiya, A; Kuwahara, N; Fujiwara, A; Matsunaga, T; Sato, Y; Okada, T; Hirai, Y; Kawashima, H; Narita, A; Niwa, K; Sekikawa, Y; Nishi, K; Nishitsuji, M; Tani, M; Suzuki, J; Nakatsumi, H; Ogura, T; Kitamura, H; Hagiwara, E; Murohashi, K; Okabayashi, H; Mochimaru, T; Nukaga, S; Satomi, R; Oyamada, Y; Mori, N; Baba, T; Fukui, Y; Odate, M; Mashimo, S; Makino, Y; Yagi, K; Hashiguchi, M; Kagyo, J; Shiomi, T; Fuke, STS; Saito, H; Tsuchida, T; Fujitani, S; Takita, M; Morikawa, D; Yoshida, T; Izumo, T; Inomata, M; Kuse, N; Awano, N; Tone, M; Ito, A; Nakamura, Y; Hoshino, K; Maruyama, J; Ishikura, H; Takata, T; Odani, T; Amishima, M; Hattori, T; Shichinohe, Y; Kagaya, T; Kita, T; Ohta, K; Sakagami, S; Koshida, K; Hayashi, K; Shimizu, T; Kozu, Y; Hiranuma, H; Gon, Y; Izumi, N; Nagata, K; Ueda, K; Taki, R; Hanada, S; Kawamura, K; Ichikado, K; Nishiyama, K; Muranaka, H; Nakamura, K; Hashimoto, N; Wakahara, K; Koji, S; Omote, N; Ando, A; Kodama, N; Kaneyama, Y; Maeda, S; Kuraki, T; Matsumoto, T; Yokote, K; Nakada, TA; Abe, R; Oshima, T; Shimada, T; Harada, M; Takahashi, T; Ono, H; Sakurai, T; Shibusawa, T; Kimizuka, Y; Kawana, A; Sano, T; Watanabe, C; Suematsu, R; Sageshima, H; Yoshifuji, A; Ito, K; Takahashi, S; Ishioka, K; Nakamura, M; Masuda, M; Wakabayashi, A; Watanabe, H; Ueda, S; Nishikawa, M; Chihara, Y; Takeuchi, M; Onoi, K; Shinozuka, J; Sueyoshi, A; Nagasaki, Y; Okamoto, M; Ishihara, S; Shimo, M; Tokunaga, Y; Kusaka, Y; Ohba, T; Isogai, S; Ogawa, A; Inoue, T; Fukuyama, S; Eriguchi, Y; Yonekawa, A; Kan-o, K; Matsumoto, K; Kanaoka, K; Ihara, S; Komuta, K; Inoue, Y; Chiba, S; Yamagata, K; Hiramatsu, Y; Kai, HRYS; Asano, K; Oguma, T; Ito, Y; Hashimoto, S; Yamasaki, M; Kasamatsu, Y; Komase, Y; Hida, N; Tsuburai, T; Oyama, B; Takada, M; Kanda, H; Kitagawa, Y; Fukuta, T; Miyake, T; Yoshida, S; Ogura, S; Abe, S; Kono, Y; Togashi, Y; Takoi, H; Kikuchi, R; Ogawa, S; Ogata, T; Ishihara, S; Kanehiro, A; Ozaki, S; Fuchimoto, Y; Wada, S; Fujimoto, N; Nishiyama, K; Terashima, M; Beppu, S; Yoshida, K; Narumoto, O; Nagai, H; Ooshima, N; Motegi, M; Umeda, A; Miyagawa, K; Shimada, H; Endo, M; Ohira, Y; Watanabe, M; Inoue, S; Igarashi, A; Sato, M; Sagara, H; Tanaka, A; Ohta, S; Kimura, T; Shibata, Y; Tanino, Y; Nikaido, T; Minemura, H; Sato, Y; Yamada, Y; Hashino, T; Shinoki, M; Iwagoe, H; Takahashi, H; Fujii, K; Kishi, H; Kanai, M; Imamura, T; Yamashita, T; Yatomi, M; Maeno, T; Hayashi, S; Takahashi, M; Kuramochi, M; Kamimaki, I; Tominaga, Y; Ishii, T; Utsugi, M; Ono, A; Tanaka, T; Kashiwada, T; Fujita, K; Saito, Y; Seike, M; Watanabe, H; Matsuse, H; Kodaka, N; Nakano, C; Oshio, T; Hirouchi, T; Makino, S; Egi, M; Omae, Y; Nannya, Y; Ueno, T; Takano, T; Katayama, K; Ai, MSM; Kumanogoh, A; Sato, T; Hasegawa, N; Tokunaga, K; Ishii, M; Koike, R; Kitagawa, Y; Kimura, A; Imoto, S; Miyano, S; Ogawa, S; Kanai, T; Fukunaga, K

    NATURE GENETICS   Vol. 55 ( 5 ) page: 753 - +   2023.5

  50. Application of a scoring system in Japanese patients diagnosed with atypical hemolytic uremic syndrome to assess the relationship between the score and clinical responses to eculizumab

    Wada, H; Teranishi, H; Shimono, A; Kato, N; Maruyama, S; Matsumoto, M

    THROMBOSIS JOURNAL   Vol. 21 ( 1 ) page: 43   2023.4

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  51. Effect of Low-Density Lipoprotein Apheresis on Quality of Life in Patients with Diabetes, Proteinuria, and Hypercholesterolemia

    Hara, A; Wada, T; Muso, E; Maruyama, S; Kato, S; Furuichi, K; Yoshimura, K; Toyama, T; Sakai, N; Suzuki, H; Tsukamoto, T; Miyazaki, M; Sato, E; Abe, M; Shibagaki, Y; Narita, I; Goto, S; Sakamaki, Y; Yokoyama, H; Mori, N; Tanaka, S; Yuzawa, Y; Hasegawa, M; Matsubara, T; Wada, J; Tanabe, K; Masutani, K; Abe, Y; Tsuruya, K; Fujimoto, S; Iwatsubo, S; Tsuda, A; Suzuki, H; Kasuno, K; Terada, Y; Nakata, T; Iino, N; Sofue, T; Miyata, H; Nakano, T; Ohtake, T; Kobayashi, S

    BLOOD PURIFICATION   Vol. 52 ( 4 ) page: 373 - 381   2023.4

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  52. Prognostic factors of IgA nephropathy presenting with mild proteinuria at the time of diagnosis (a multicenter cohort study)

    Shirai, S; Yasuda, T; Kumagai, H; Matsunobu, H; Ichikawa, D; Shibagaki, Y; Yasuda, Y; Matsuzaki, K; Hirano, K; Kawamura, T; Suzuki, Y; Maruyama, S

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 27 ( 4 ) page: 340 - 348   2023.4

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  53. Long non-coding RNA lnc-CHAF1B-3 promotes renal interstitial fibrosis by regulating EMT-related genes in renal proximal tubular cells

    Imai, K; Ishimoto, T; Doke, T; Tsuboi, T; Watanabe, Y; Katsushima, K; Suzuki, M; Oishi, H; Furuhashi, K; Ito, Y; Kondo, Y; Maruyama, S

    MOLECULAR THERAPY NUCLEIC ACIDS   Vol. 31   page: 139 - 150   2023.3

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  54. Serum and plasma levels of Ba, but not those of soluble C5b-9, might be affected by renal function in chronic kidney disease patients

    Yamane, R; Yasuda, Y; Oshima, A; Suzuki, Y; Kojima, H; Kim, H; Fukui, S; Maruyama, S; Ito, Y; Mizuno, M

    BMC NEPHROLOGY   Vol. 24 ( 1 ) page: 26   2023.2

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  55. Non-A Blood Type Is a Risk Factor for Poor Cardio-Cerebrovascular Outcomes in Patients Undergoing Dialysis

    Nakayama, T; Yamamoto, J; Ozeki, T; Tsuruta, Y; Yokoi, M; Aoi, T; Mori, Y; Hori, M; Tsujita, M; Shirasawa, Y; Kondo, C; Yasuda, K; Murata, M; Kinoshita, Y; Suzuki, S; Fukuda, M; Yamazaki, C; Ikehara, N; Sugiura, M; Goto, T; Hashimoto, H; Yajima, K; Maruyama, S; Morozumi, K; Seo, Y

    BIOMEDICINES   Vol. 11 ( 2 )   2023.2

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  56. Assessment of Antibody-Titer Changes after Second and Third Severe Acute Respiratory Syndrome Coronavirus 2 mRNA Vaccination in Japanese Post-Kidney-Transplant Patients

    Fujieda, K; Tanaka, A; Kikuchi, R; Takai, N; Saito, S; Yasuda, Y; Fujita, T; Kato, M; Furuhashi, K; Maruyama, S

    VACCINES   Vol. 11 ( 1 )   2023.1

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  57. Efficacy of On-line Hemodiafiltration for Rhabdomyolysis Presenting with Acute Kidney Injury Due to Unexpected Drug Abuse

    Sato Naokazu, Inagaki Koji, Takanashi Masahiro, Muto Reiko, Kato Noritoshi, Maruyama Shoichi, Akahori Toshiyuki

    Internal Medicine   Vol. 62 ( 19 ) page: 2865 - 2870   2023

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    <p>Myoglobin is a well-known cause of acute kidney injury (AKI) due to rhabdomyolysis. However, whether or not removing serum myoglobin by on-line hemodiafiltration (OHDF) improves the kidney function remains unclear. We herein report a patient with a history of methamphetamine abuse who developed AKI due to rhabdomyolysis. A urinalysis and blood collection results obtained before and after OHDF demonstrated that OHDF improved the kidney function by removing a large amount of serum myoglobin rather than via urinary excretion. In conclusion, OHDF may prevent AKI progression effectively when the urine volume is insufficient. </p>

    DOI: 10.2169/internalmedicine.1107-22

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  58. Recurrent Cerebrovascular Complications under Enzyme Replacement Therapy in a Patient with Fabry Disease on Peritoneal Dialysis

    Muto Reiko, Suzuki Yasuhiro, Shimizu Hideaki, Yasuda Kaoru, Ishimoto Takuji, Maruyama Shoichi, Ito Yasuhiko, Mizuno Masashi

    Internal Medicine   Vol. 62 ( 3 ) page: 565 - 569   2023

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    <p>Fabry disease is an X-linked lysosomal storage disorder due to mutations in the alpha-galactosidase A gene, which leads to the accumulation of globotriaosylceramide in various organs. In Fabry disease with end-stage renal disease (ESRD), cerebrovascular events are lethal, even with enzyme replacement therapy (ERT). However, the utility of biomarkers to evaluate the ERT response is unclear. We herein report a case of recurrent cerebrovascular complications under ERT in a Fabry disease patient, progressing to ESRD on peritoneal dialysis. Further studies are warranted, but Fabry disease patients with ESRD receiving ERT might need careful long-term follow-up in cases with cerebrovascular manifestations. </p>

    DOI: 10.2169/internalmedicine.0185-22

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  59. The Impact of Liver Chemistries on Respiratory Failure among Hemodialysis Patients with COVID-19 during the Omicron Wave

    Hori Mayuko, Yasuda Kaoru, Takahashi Hiroshi, Aoi Tomonori, Mori Yoshiko, Tsujita Makoto, Shirasawa Yuichi, Kondo Chika, Hashimoto Takashi, Koyama Hiroichi, Morozumi Kunio, Maruyama Shoichi

    Internal Medicine   Vol. 62 ( 18 ) page: 2617 - 2625   2023

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    <p><b>Objective </b>Although the coronavirus disease 2019 (COVID-19) Omicron variant causes less severe symptoms than previous variants, early indicators for respiratory failure are needed in hemodialysis patients, who have a higher mortality rate than the general population. Liver chemistries are known to reflect the severity of COVID-19 in the general population. This study explored the early indicators for worsened respiratory failure based on patient characteristics, including liver chemistries. </p><p><b>Methods </b>This retrospective study included 117 patients admitted for COVID-19 during the Omicron wave. Respiratory failure was defined as oxygen requirement during treatment. Information on the symptoms and clinical characteristics, including liver chemistries [aspartate aminotransferase (AST) and alanine aminotransferase (ALT)], at admission was collected. </p><p><b>Results </b>Thirty-five patients (29.9%) required oxygen supply during treatment. In the multivariate logistic regression analyses, AST [odds ratio (OR) 1.06, 95% confidence interval (CI) 1.00-1.13, p=0.029], ALT (OR 1.09, 95% CI 1.02-1.18, p=0.009), and moderate COVID-19 illness (Model including AST, OR 6.95, 95% CI 2.23-23.17, p<0.001; Model including ALT, OR 7.19, 95% CI 2.21-25.22, p=0.001) were independent predictors for respiratory failure. Based on the cutoff values determined by the receiver operating characteristic curve, higher AST (≥23 IU/L) and ALT levels (≥14 IU/L) were also independently associated with respiratory failure (higher AST: 64.3% vs. 18.8%, OR 3.44, 95% CI 1.08-11.10, p=0.035; higher ALT: 48.8% vs. 19.7%, OR 4.23, 95% CI 1.34-14.52, p=0.013, respectively). </p><p><b>Conclusion </b>The measurement of AST and ALT levels at baseline may help predict oxygen requirement in hemodialysis patients with COVID-19. </p>

    DOI: 10.2169/internalmedicine.2115-23

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  60. Long-term peritoneal dialysate exposure modulates expression of membrane complement regulators in human peritoneal mesothelial cells

    Kobayashi, K; Ozeki, T; Kim, H; Imai, M; Kojima, H; Iguchi, D; Fukui, S; Suzuki, M; Suzuki, Y; Maruyama, S; Ito, Y; Mizuno, M

    FRONTIERS IN MEDICINE   Vol. 9   page: 972592   2022.12

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  61. Deep learning analysis of clinical course of primary nephrotic syndrome: Japan Nephrotic Syndrome Cohort Study (JNSCS)

    Kimura, T; Yamamoto, R; Yoshino, M; Sakate, R; Imai, E; Maruyama, S; Yokoyama, H; Sugiyama, H; Nitta, K; Tsukamoto, T; Uchida, S; Takeda, A; Sato, T; Wada, T; Hayashi, H; Akai, Y; Fukunaga, M; Tsuruya, K; Masutani, K; Konta, T; Shoji, T; Hiramatsu, T; Goto, S; Tamai, H; Nishio, S; Nagai, K; Yamagata, K; Yasuda, H; Ichida, S; Naruse, T; Nishino, T; Sobajima, H; Akahori, T; Ito, T; Terada, Y; Katafuchi, R; Fujimoto, S; Okada, H; Mimura, T; Suzuki, S; Saka, Y; Sofue, T; Kitagawa, K; Fujita, Y; Mizutani, M; Kashihara, N; Sato, H; Narita, I; Isaka, Y

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 26 ( 12 ) page: 1170 - 1179   2022.12

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  62. Predicting oxygen requirements in patients with coronavirus disease 2019 using an artificial intelligence-clinician model based on local non-image data

    Muto, R; Fukuta, S; Watanabe, T; Shindo, Y; Kanemitsu, Y; Kajikawa, S; Yonezawa, T; Inoue, T; Ichihashi, T; Shiratori, Y; Maruyama, S

    FRONTIERS IN MEDICINE   Vol. 9   page: 1042067   2022.11

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  63. Systematic characterization of seed overlap microRNA cotargeting associated with lupus pathogenesis

    Kitai, H; Kato, N; Ogami, K; Komatsu, S; Watanabe, Y; Yoshino, S; Koshi, E; Tsubota, S; Funahashi, Y; Maeda, T; Furuhashi, K; Ishimoto, T; Kosugi, T; Maruyama, S; Kadomatsu, K; Suzuki, HI

    BMC BIOLOGY   Vol. 20 ( 1 ) page: 248   2022.11

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  64. Influence of COVID-19 on the 10-year carbon footprint of the Nagoya University Hospital and medical research centre

    Morooka, H; Yamamoto, T; Tanaka, A; Furuhashi, K; Miyagawa, Y; Maruyama, S

    GLOBALIZATION AND HEALTH   Vol. 18 ( 1 ) page: 92   2022.11

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  65. Identifying high-risk population of depression: association between metabolic syndrome and depression using a health checkup and claims database

    Imaizumi, T; Toda, T; Maekawa, M; Sakurai, D; Hagiwara, Y; Yoshida, Y; Ando, M; Maruyama, S

    SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page: 18577   2022.11

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  66. TWO PHASE III TRIALS EVALUATING CROVALIMAB IN PATIENTS WITH ATYPICAL HAEMOLYTIC UREMIC SYNDROME (AHUS): COMMUTE-A AND COMMUTE-P

    Sheerin, N; Greenbaum, LA; Ito, S; Loirat, C; Maruyama, S; Zhao, MH; Benkali, K; Pieterse, C; Shah, MD; Sostelly, A; Sreckovic, S; Fakhouri, F

    PEDIATRIC NEPHROLOGY   Vol. 37 ( 11 ) page: 2849 - 2849   2022.11

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  67. Acute Kidney Injury and Remission of Proteinuria in Minimal Change Disease

    Yamamoto, R; Imai, E; Maruyama, S; Yokoyama, H; Sugiyama, H; Takeda, A; Uchida, S; Tsukamoto, T; Tsuruya, K; Akai, Y; Nitta, K; Fukunaga, M; Hayashi, H; Shoji, T; Masutani, K; Konta, T; Katafuchi, R; Nishio, S; Wada, T; Goto, S; Tamai, H; Shirasaki, A; Nagai, K; Nishino, T; Yamagata, K; Kazama, JJ; Hiromura, K; Yasuda, H; Sofue, T; Fujimoto, S; Mizutani, M; Naruse, T; Hiramatsu, T; Morozumi, K; Sobajima, H; Saka, Y; Ishimura, E; Ito, T; Ichikawa, D; Shigematsu, T; Sato, H; Narita, I; Yoshitaka, I

    KIDNEY INTERNATIONAL REPORTS   Vol. 7 ( 10 ) page: 2283 - 2288   2022.10

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  68. A nationwide analysis of renal and patient outcomes for adults with lupus nephritis in Japan

    Ikeuchi, H; Sugiyama, H; Sato, H; Yokoyama, H; Maruyama, S; Mukoyama, M; Hayashi, H; Tsukamoto, T; Fukuda, M; Yamagata, K; Ishikawa, E; Uchida, K; Kamijo, Y; Nakagawa, N; Tsuruya, K; Nojima, Y; Hiromura, K

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 26 ( 9 ) page: 898 - 908   2022.9

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  69. New-onset and relapse of nephrotic syndrome following COVID-19 vaccination: a questionnaire survey in Japan

    Nakagawa, N; Maruyama, S; Kashihara, N; Narita, I; Isaka, Y

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 26 ( 9 ) page: 909 - 916   2022.9

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  70. Impact of etelcalcetide on fibroblast growth factor-23 and calciprotein particles in patients with secondary hyperparathyroidism undergoing haemodialysis

    Hashimoto, Y; Kato, S; Kuro-o, M; Miura, Y; Itano, Y; Ando, M; Kuwatsuka, Y; Maruyama, S

    NEPHROLOGY   Vol. 27 ( 9 ) page: 763 - 770   2022.9

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  71. Mesenchymal stem cells exert renoprotection via extracellular vesicle-mediated modulation of M2 macrophages and spleen-kidney network

    Shimamura, Y; Furuhashi, K; Tanaka, A; Karasawa, M; Nozaki, T; Komatsu, S; Watanabe, K; Shimizu, A; Minatoguchi, S; Matsuyama, M; Sawa, Y; Tsuboi, N; Ishimoto, T; Suzuki, HI; Maruyama, S

    COMMUNICATIONS BIOLOGY   Vol. 5 ( 1 ) page: 753   2022.7

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  72. 特集 多臓器不全と急性腎障害(AKI) 【各論】 臓器障害とAKI ネフローゼ症候群

    前田 佳哉輔, 丸山 彰一

    腎と透析   Vol. 93 ( 1 ) page: 85 - 89   2022.7

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    Publisher:東京医学社  

    DOI: 10.24479/kd.0000000236

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  73. Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study

    Yamamoto, R; Imai, E; Maruyama, S; Yokoyama, H; Sugiyama, H; Takeda, A; Uchida, S; Tsukamoto, T; Tsuruya, K; Akai, Y; Nitta, K; Fukunaga, M; Hayashi, H; Masutani, K; Wada, T; Konta, T; Katafuchi, R; Nishio, S; Goto, S; Tamai, H; Shirasaki, A; Shoji, T; Nagai, K; Nishino, T; Yamagata, K; Kazama, JJ; Hiromura, K; Yasuda, H; Mizutani, M; Naruse, T; Hiramatsu, T; Morozumi, K; Sobajima, H; Saka, Y; Ishimura, E; Ichikawa, D; Shigematsu, T; Sofue, T; Fujimoto, S; Ito, T; Sato, H; Narita, I; Isaka, Y

    SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page: 9782   2022.6

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  74. Mortality and Cardiovascular Events in Patients With Chronic Kidney Disease and Sleep Apnea Syndrome

    Watanabe, Y; Tanaka, A; Furuhashi, K; Saito, S; Maruyama, S

    FRONTIERS IN MEDICINE   Vol. 9   page: 899359   2022.5

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  75. Protocol for a Phase 1, Open-Label, Multiple-Center, Dose-Escalation Study to Evaluate the Safety and Tolerability of ADR-001 in the Treatment of Immunoglobulin A Nephropathy

    Tanaka, A; Furuhashi, K; Fujieda, K; Maeda, K; Saito, S; Mimura, T; Saka, Y; Naruse, T; Ishimoto, T; Kosugi, T; Kinoshita, F; Kuwatsuka, Y; Shimizu, S; Nakai, Y; Maruyama, S

    FRONTIERS IN MEDICINE   Vol. 9   page: 883168   2022.5

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  76. Effects of bone turnover status on the efficacy and safety of denosumab among haemodialysis patients

    Hori, M; Yasuda, K; Takahashi, H; Kondo, C; Shirasawa, Y; Ishimaru, Y; Sekiya, Y; Morozumi, K; Maruyama, S

    SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page: 7781   2022.5

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  77. Electrolyte Imbalance in Daily Clinical Practice

    Maruyama Shoichi

    Nihon Naika Gakkai Zasshi   Vol. 111 ( 5 ) page: 899 - 901   2022.5

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    Language:Japanese   Publisher:The Japanese Society of Internal Medicine  

    DOI: 10.2169/naika.111.899

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  78. ECULIZUMAB FOR ADULT PATIENTS WITH ATYPICAL HAEMOLYTIC-UREMIC SYNDROME: FULL DATASET ANALYSIS OF POST-MARKETING SURVEILLANCE IN JAPAN

    Maruyama, S; Ikeda, Y; Kaname, S; Kato, N; Matsumoto, M; Ishikawa, Y; Shimono, A; Miyakawa, Y; Nangaku, M; Shibagaki, Y; Okada, H

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 37   page: I231 - I232   2022.5

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  79. Antibody response to double SARS-CoV-2 mRNA vaccination in Japanese kidney transplant recipients

    Fujieda, K; Tanaka, A; Kikuchi, R; Takai, N; Saito, S; Yasuda, Y; Fujita, T; Kato, M; Furuhashi, K; Maruyama, S

    SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page: 6850   2022.4

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  80. Time to remission of proteinuria and incidence of relapse in patients with steroid-sensitive minimal change disease and focal segmental glomerulosclerosis: the Japan Nephrotic Syndrome Cohort Study.

    Yamamoto R, Imai E, Maruyama S, Yokoyama H, Sugiyama H, Takeda A, Tsukamoto T, Uchida S, Tsuruya K, Shoji T, Hayashi H, Akai Y, Fukunaga M, Konta T, Nishio S, Goto S, Tamai H, Nagai K, Katafuchi R, Masutani K, Wada T, Nishino T, Shirasaki A, Sobajima H, Nitta K, Yamagata K, Kazama JJ, Hiromura K, Yasuda H, Mizutani M, Akahori T, Naruse T, Hiramatsu T, Morozumi K, Mimura T, Saka Y, Ishimura E, Hasegawa H, Ichikawa D, Shigematsu T, Sato H, Narita I, Isaka Y, Japan Nephrotic Syndrome Cohort Study investigators.

    Journal of nephrology     2022.4

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    Language:English  

    DOI: 10.1007/s40620-022-01279-z

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  81. A novel renal perivascular mesenchymal cell subset gives rise to fibroblasts distinct from classic myofibroblasts.

    Minatoguchi S, Saito S, Furuhashi K, Sawa Y, Okazaki M, Shimamura Y, Kaihan AB, Hashimoto Y, Yasuda Y, Hara A, Mizutani Y, Ando R, Kato N, Ishimoto T, Tsuboi N, Esaki N, Matsuyama M, Shiraki Y, Kobayashi H, Asai N, Enomoto A, Maruyama S

    Scientific reports   Vol. 12 ( 1 ) page: 5389   2022.3

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    DOI: 10.1038/s41598-022-09331-5

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  82. Biopsy-proven CKD etiology and outcomes: Chronic Kidney Disease Japan Cohort (CKD-JAC) study.

    Hamano T, Imaizumi T, Hasegawa T, Fujii N, Komaba H, Ando M, Nangaku M, Nitta K, Hirakata H, Isaka Y, Wada T, Maruyama S, Fukagawa M

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     2022.3

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    DOI: 10.1093/ndt/gfac134

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  83. Lateral spine dual-energy X-ray absorptiometry and the risk of fragility fractures in long-term kidney graft recipients

    Hori Mayuko, Yasuda Kaoru, Takahashi Hiroshi, Matsuoka Yutaka, Tsujita Makoto, Nishihira Morikuni, Uchida Kazuharu, Morozumi Kunio, Maruyama Shoichi

    CLINICAL AND EXPERIMENTAL NEPHROLOGY     2022.3

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  84. Impact of left ventricular hypertrophy on clinical outcomes in patients with dialysis: a single-center study in Japan

    Nakayama Takafumi, Yamamoto Junki, Ozeki Toshikazu, Yasuda Kaoru, Yamazaki Chikao, Ito Tsuyoshi, Goto Toshihiko, Maruyama Shoichi, Morozumi Kunio, Seo Yoshihiro

    JOURNAL OF MEDICAL ULTRASONICS     2022.3

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  85. Long-term Effectiveness of a Primary Care Practice Facilitation Program for Chronic Kidney Disease Management: An Extended Follow-up of a Cluster-Randomized FROM-J Study.

    Imasawa T, Saito C, Kai H, Iseki K, Kazama JJ, Shibagaki Y, Sugiyama H, Nagata D, Narita I, Nishino T, Hasegawa H, Honda H, Maruyama S, Miyazaki M, Mukoyama M, Yasuda H, Wada T, Ishikawa Y, Tsunoda R, Nagai K, Okubo R, Kondo M, Hoshino J, Yamagata K

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     2022.2

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    DOI: 10.1093/ndt/gfac041

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  86. Clustering phosphate and iron-related markers and prognosis in dialysis patients

    Morooka, H; Tanaka, A; Inaguma, D; Maruyama, S

    CLINICAL KIDNEY JOURNAL   Vol. 15 ( 2 ) page: 328 - 337   2022.2

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  87. Favorable therapeutic efficacy of low-density lipoprotein apheresis for nephrotic syndrome with impaired renal function.

    Muso E, Sakai S, Ogura Y, Yukawa S, Nishizawa Y, Yorioka N, Saito T, Mune M, Sugiyama S, Iino Y, Hirano T, Hattori M, Watanabe T, Yokoyama H, Sato H, Uchida S, Wada T, Shoji T, Oda H, Mori K, Kimura H, Ito O, Nishiyama A, Maruyama S, Inagi R, Fujimoto S, Tsukamoto T, Suzuki Y, Honda H, Babazono T, Tsuruya K, Yuzawa Y

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy   Vol. 26 ( 1 ) page: 220 - 228   2022.2

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    DOI: 10.1111/1744-9987.13694

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  88. Sex differences in clinical outcomes in Japanese incident dialysis patients: a prospective observational multicenter study

    Kozaki Yohei, Morinaga Takatoshi, Fukatsu Atsushi, Ito Takeshi, Ishimoto Takuji, Kosugi Tomoki, Inaguma Daijo, Tamai Hirofumi, Maruyama Shoichi

    CLINICAL AND EXPERIMENTAL NEPHROLOGY     2022.1

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  89. Expression of a Crry/p65 is reduced in acute lung injury induced by extracellular histones

    Nagano Fumihiko, Mizuno Tomohiro, Imai Masaki, Takahashi Kazuo, Tsuboi Naotake, Maruyama Shoichi, Mizuno Masashi

    FEBS OPEN BIO   Vol. 12 ( 1 ) page: 192 - 202   2022.1

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  90. 植込み型補助人工心臓入れ替え術後に偽性高クレアチニン血症を来した一例

    安田 宜成, 金 恒秀, 石川 裕介, 斎藤 尚二, 加藤 規利, 小杉 智規, 六鹿 雅登, 丸山 彰一

    移植   Vol. 57 ( Supplement ) page: s335_3 - s335_3   2022

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    <p>症例は50歳代男性。Xー12年に心不全のためA病院入院。心筋生検にて拡張型心筋症と診断。その後入退院を繰り返し、心臓移植申請を目的にX-5年7月に名大病院紹介となった。心臓移植適応判定を得て、同年10月に植込み型補助人工心臓(HM-II)植え込み術施行。X年3月24日にドライブラインの断線疑いでHM-IIIへ入れ替え術施行。術後に尿路感染合併し4月2日より抗菌薬治療開始したところ、sCr(mg/dL)0.79-0.96から2.49へと悪化し、その後も改善しないため、4月4日腎臓内科紹介された。CTでは左胸水少量認め、IVC虚脱や水腎症を認めず、腎機能障害の原因は不明であった。ARB中止して経過観察したが4月8日sCr3.02と腎機能は改善せず,別の腎機能検査であるsCysC(mg/L)は0.91と著しい乖離を認めた。4月18日イヌリンクリアランス検査を行い実測GFR84.2(mL/分/1.73m2)、sCr.2.59,sCysC0.85、eGFRcreat21.3,eGFRcys88.8であり、偽性高Cr血症が疑われた。そこで酵素法(シグナスオートCRE)とHPLC法でsCrを比較したところ2.4と0.8であった。酵素法のR-Ⅱ試薬添加後に副波長の吸光度が上昇し続けており、血清に含めれる蛋白成分による混濁が疑われた。その後はsCrは希釈無し、2倍、4倍希釈で評価しており、各々3.23~4.69,0.76~1.14、0.76~0.96であった。心臓移植待機者において偽性高Cr血症を経験したため文献的考察を含め報告する。</p>

    DOI: 10.11386/jst.57.supplement_s335_3

    CiNii Research

  91. 腎移植レシピエントにおけるSARS-CoV-2 mRNAワクチン接種後の抗体獲得率

    安田 宜成, 田中 章仁, 菊地 良介, 高井 奈美, 齋藤 尚二, 藤田 高史, 加藤 真史, 古橋 和拡, 丸山 彰一

    移植   Vol. 57 ( Supplement ) page: s270_3 - s270_3   2022

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    <p>【背景】腎移植レシピエントでは免疫抑制療法のためSARS-CoV-2 mRNA vaccinat</p><p>ionによる抗体獲得率が低いと報告されている。本邦では諸外国と比較し、生体腎移植が多く、免疫抑制薬の治療レジメなどが異なる。日本人腎移植レシピエントのワクチン接種後の交代獲得率を調査した。</p><p>【方法】対象は名古屋大学医学部付属病院へ通院中の日本人腎移植レシピエントのうち、SARS-CoV-2 mRNAワクチンを受けて、抗体価を測定した106名。抗体価は2回のワクチン接種後3週間から3か月の間にSARS-CoV-2 IgG II Quant Reagent Kit(R)により測定し、50 AU/mL以上を陽性とした。</p><p>【結果】対象者106名中で陽性は41名(38.6%)であった。抗体獲得率に関連する因子として、BMI(OR 1.24, 95% CI 1.08-1.41, P<0.05)、移植からの期間(OR 1.01, 95% CI 1.00-1.02, P<0.05)、eGFR(OR 1.07, 95% CI 1.02-1.11, P<0.05)が関連した。</p><p>【結論】腎移植レシピエントはSARS-CoV-2 mRNAワクチン接種後の抗体獲得率が低く、ワクチン接種後も厳重な感染対策を継続しなければならない。加えて免疫抑制治療中の患者において抗体獲得率を高めるSARS-CoV-2 mRNAワクチン接種方法の検討が必要である。</p>

    DOI: 10.11386/jst.57.supplement_s270_3

    CiNii Research

  92. 膜性腎症の診断と治療

    丸山 彰一, 秋山 真一

    日本腎臓学会誌   Vol. 64(3)   page: 177   2022

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  93. Increased Monocyte/Lymphocyte Ratio as Risk Marker for Cardiovascular Events and Infectious Disease Hospitalization in Dialysis Patients.

    Muto R, Kato S, Lindholm B, Qureshi AR, Ishimoto T, Kosugi T, Maruyama S

    Blood purification     page: 1 - 9   2021.11

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    DOI: 10.1159/000519289

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  94. The 30-year Natural History of Non-classic Fabry Disease with an R112H Mutation.

    Muto R, Inagaki K, Kato N, Maruyama S, Akahori T

    Internal medicine (Tokyo, Japan)     2021.11

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    <p>Fabry disease is a rare X-linked lysosomal storage disorder caused by mutations in the alpha-galactosidase A (GLA) gene that results in deficiency of the enzyme GLA and leads to the accumulation of globotriaosylceramide (GL-3) in cells. The accumulation of GL-3 may lead to life-threatening complications. Significant advances in genetic sequencing technology have led to a better understanding of genotype-phenotype interactions in Fabry disease. Fabry disease with an R112H mutation is known as the non-classic type. However, the long-term clinical course of the disease remains unknown. We herein report a patient with a 30-year natural history of non-classic Fabry disease with an R112H mutation. </p>

    DOI: 10.2169/internalmedicine.8213-21

    PubMed

  95. X-chromosome inactivation patterns in females with Fabry disease examined by both ultra-deep RNA sequencing and methylation-dependent assay

    Rossanti Rini, Nozu Kandai, Fukunaga Atsushi, Nagano China, Horinouchi Tomoko, Yamamura Tomohiko, Sakakibara Nana, Minamikawa Shogo, Ishiko Shinya, Aoto Yuya, Okada Eri, Ninchoji Takeshi, Kato Noritoshi, Maruyama Shoichi, Kono Keiji, Nishi Shinichi, Iijima Kazumoto, Fujii Hideki

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 25 ( 11 ) page: 1224 - 1230   2021.11

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  96. Kidney Outcomes Associated With SGLT2 Inhibitors Versus Other Glucose-Lowering Drugs in Real-world Clinical Practice: The Japan Chronic Kidney Disease Database.

    Nagasu H, Yano Y, Kanegae H, Heerspink HJL, Nangaku M, Hirakawa Y, Sugawara Y, Nakagawa N, Tani Y, Wada J, Sugiyama H, Tsuruya K, Nakano T, Maruyama S, Wada T, Yamagata K, Narita I, Tamura K, Yanagita M, Terada Y, Shigematsu T, Sofue T, Ito T, Okada H, Nakashima N, Kataoka H, Ohe K, Okada M, Itano S, Nishiyama A, Kanda E, Ueki K, Kashihara N

    Diabetes care   Vol. 44 ( 11 ) page: 2542 - 2551   2021.11

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    DOI: 10.2337/dc21-1081

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  97. Abnormal magnesium levels and their impact on death and acute kidney injury in critically ill children

    Morooka Hikaru, Tanaka Akihito, Kasugai Daisuke, Ozaki Masayuki, Numaguchi Atsushi, Maruyama Shoichi

    PEDIATRIC NEPHROLOGY     2021.10

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  98. Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis

    Ryuge, A; Kosugi, T; Maeda, K; Banno, R; Gou, Y; Zaitsu, K; Ito, T; Sato, Y; Hirayama, A; Tsubota, S; Honda, T; Nakajima, K; Ozaki, T; Kondoh, K; Takahashi, K; Kato, N; Ishimoto, T; Soga, T; Nakagawa, T; Koike, T; Arima, H; Yuzawa, Y; Minokoshi, Y; Maruyama, S; Kadomatsu, K

    JCI INSIGHT   Vol. 6 ( 20 )   2021.10

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  99. Effect of body mass index on the association between alcohol consumption and the development of chronic kidney disease

    Hashimoto Yusaku, Imaizumi Takahiro, Kato Sawako, Yasuda Yoshinari, Ishimoto Takuji, Kawashiri Hiroaki, Hori Akihiro, Maruyama Shoichi

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 20440   2021.10

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  100. Epidemiology and temporal changes in the prognosis of rapidly progressive glomerulonephritis in Japan: a nationwide 1989-2015 survey

    Kaneko Shuzo, Yamagata Kunihiro, Usui Joichi, Tsuboi Naotake, Sugiyama Hitoshi, Maruyama Shoichi, Narita Ichiei

    CLINICAL AND EXPERIMENTAL NEPHROLOGY     2021.10

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  101. Kidney biopsy guidebook 2020 in Japan (vol 25, pg 325, 2021)

    Ubara Yoshifumi, Kawaguchi Takehiko, Nagasawa Tasuku, Miura Kenichiro, Katsuno Takayuki, Morikawa Takashi, Ishikawa Eiji, Ogura Masao, Matsumura Hideki, Kurayama Ryota, Matsumoto Shinsuke, Marui Yuhji, Hara Shigeo, Maruyama Shoichi, Narita Ichiei, Okada Hirokazu, Tsuruya Kazuhiko

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 25 ( 10 ) page: 1161 - 1161   2021.10

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  102. Urinary Metabolome Analyses of Patients with Acute Kidney Injury Using Capillary Electrophoresis-Mass Spectrometry

    Saito Rintaro, Hirayama Akiyoshi, Akiba Arisa, Kamei Yushi, Kato Yuyu, Ikeda Satsuki, Kwan Brian, Pu Minya, Natarajan Loki, Shinjo Hibiki, Akiyama Shin'ichi, Tomita Masaru, Soga Tomoyoshi, Maruyama Shoichi

    METABOLITES   Vol. 11 ( 10 )   2021.10

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  103. Demographic, clinical characteristics and treatment outcomes of immune-complex membranoproliferative glomerulonephritis and C3 glomerulonephritis in Japan: A retrospective analysis of data from the Japan Renal Biopsy Registry

    Nakagawa Naoki, Mizuno Masashi, Kato Sawako, Maruyama Shoichi, Sato Hiroshi, Nakaya Izaya, Sugiyama Hitoshi, Fujimoto Shouichi, Miura Kenichiro, Matsumura Chieko, Gotoh Yoshimitsu, Suzuki Hitoshi, Kuroki Aki, Yoshino Atsunori, Nakatani Shinya, Hiromura Keiju, Yamamoto Ryohei, Yokoyama Hitoshi, Narita Ichiei, Isaka Yoshitaka

    PLOS ONE   Vol. 16 ( 9 ) page: e0257397   2021.9

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  104. 10. Diagnosis and Treatment of Nephrotic Syndrome

    Maruyama Shoichi, Akiyama Shin' ichi, Ishimoto Takuji

    Nihon Naika Gakkai Zasshi   Vol. 110 ( 9 ) page: 1972 - 1980   2021.9

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    DOI: 10.2169/naika.110.1972

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  105. Focal segmental glomerulosclerosis histologic variants and renal outcomes based on nephrotic syndrome, immunosuppression, and proteinuria remission.

    Kawaguchi T, Imasawa T, Kadomura M, Kitamura H, Maruyama S, Ozeki T, Katafuchi R, Oka K, Isaka Y, Yokoyama H, Sugiyama H, Sato H

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     2021.9

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    DOI: 10.1093/ndt/gfab267

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  106. A NATIONWIDE SURVEY OF THE TIMING AND OCCASION OF DIAGNOSIS OF RARE AND INTRACTABLE PEDIATRIC KIDNEY DISEASES IN JAPAN

    Hamada Riku, Hamasaki Yuko, Uemura Osamu, Hattori Motoshi, Nakanishi Koichi, Maruyama Shoichi, Ito Shuichi, Morisada Naoya, Nozu Kandai, Harita Yutaka, Harada Ryoko, Kaneko Tetsuji, Honda Masataka, Ishikura Kenji

    PEDIATRIC NEPHROLOGY   Vol. 36 ( 9 ) page: 2910 - 2911   2021.9

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  107. Roles of glomerular endothelial hyaluronan in the development of proteinuria

    Asai, A; Hatayama, N; Kamiya, K; Yamauchi, M; Kinashi, H; Yamaguchi, M; Katsuno, T; Nobata, H; Watanabe, K; Wakatsuki, A; Aten, J; Maruyama, S; Ishimoto, T; Hirai, S; Naito, M; Ito, Y

    PHYSIOLOGICAL REPORTS   Vol. 9 ( 17 ) page: e15019   2021.9

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  108. Low-GDP, pH-neutral solutions preserve peritoneal endothelial glycocalyx during long-term peritoneal dialysis

    Sugiyama Naoya, Tawada Mitsuhiro, Sun Ting, Suzuki Yasuhiro, Kinashi Hiroshi, Yamaguchi Makoto, Katsuno Takayuki, Aten Jan, Vlahu Carmen A., van Kuppevelt Toin H., Takei Yoshifumi, Ishimoto Takuji, Maruyama Shoichi, Mizuno Masashi, Ito Yasuhiko

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 25 ( 9 ) page: 1035 - 1046   2021.9

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  109. Factors predicting decline in renal function and kidney volume growth in autosomal dominant polycystic kidney disease: a prospective cohort study (Japanese Polycystic Kidney Disease registry: J-PKD)

    Uchiyama Kiyotaka, Mochizuki Toshio, Shimada Yosuke, Nishio Saori, Kataoka Hiroshi, Mitobe Michihiro, Tsuchiya Ken, Hanaoka Kazushige, Ubara Yoshifumi, Suwabe Tatsuya, Sekine Akinari, Nutahara Kikuo, Tsuruya Kazuhiko, Ishimura Eiji, Nakatani Shinya, Sofue Tadashi, Tanaka Satoshi, Narita Ichiei, Maruyama Shoichi, Horie Shigeo, Muto Satoru

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 25 ( 9 ) page: 970 - 980   2021.9

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  110. 特集 腎疾患治療薬update (第1章)腎疾患患者への薬の使い方 ループス腎炎 ミコフェノール酸モフェチル

    前田 佳哉輔, 丸山 彰一

    腎と透析   Vol. 91 ( 7 ) page: 131 - 135   2021.8

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    DOI: 10.24479/j00714.2022002642

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  111. All-cause and cardiovascular mortality in patients undergoing hemodialysis with aortic sclerosis and mild-to-moderate aortic stenosis: A cohort study

    Kurasawa Shimon, Hishida Manabu, Imaizumi Takahiro, Okazaki Masaki, Nishibori Nobuhiro, Kondo Toru, Kasuga Hirotake, Maruyama Shoichi

    ATHEROSCLEROSIS   Vol. 331   page: 12 - 19   2021.8

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  112. Novel anti-GARP antibody DS-1055a augments anti-tumor immunity by depleting highly suppressive GARP(+) regulatory T cells

    Satoh Kazuki, Kobayashi Yoichi, Fujimaki Kaori, Hayashi Shinko, Ishida Saori, Sugiyama Daisuke, Sato Takahiko, Lim Kyungtaek, Miyamoto Megumi, Kozuma Shiho, Kadokura Michinori, Wakita Kenichi, Hata Masato, Hirahara Kazuki, Amano Masato, Watanabe Ichiro, Okamoto Atsushi, Tuettenberg Andrea, Jonuleit Helmut, Tanemura Atsushi, Maruyama Shoichi, Agatsuma Toshinori, Wada Teiji, Nishikawa Hiroyoshi

    INTERNATIONAL IMMUNOLOGY   Vol. 33 ( 8 ) page: 435 - 446   2021.8

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  113. Multi-Walled Carbon Nanotube-Assisted Encapsulation Approach for Stable Perovskite Solar Cells

    Choi Jin-Myung, Suko Hiroki, Kim Kyusun, Han Jiye, Lee Sangsu, Matsuo Yutaka, Maruyama Shigeo, Jeon Il, Daiguji Hirofumi

    MOLECULES   Vol. 26 ( 16 )   2021.8

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    DOI: 10.3390/molecules26165060

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  114. 特集 腎臓医が診る指定難病 指定難病各論 遺伝性腎疾患 非典型溶血性尿毒症症候群(aHUS)/血栓性血小板減少性紫斑病(TTP)

    加藤 規利, 立枩 良崇, 丸山 彰一

    腎と透析   Vol. 91 ( 1 ) page: 94 - 102   2021.7

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    DOI: 10.24479/j00714.2021334163

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  115. Anti-GARP antibody DS-1055a augments antitumor immunity by depleting highly suppressive GARP(+) regulatory T cells.

    Satoh Kazuki, Kobayashi Yoichi, Fujimaki Kaori, Hata Masato, Hayashi Shinko, Ishida Saori, Sugiyama Daisuke, Sato Takahiko, Kyungtaek Lim, Miyamoto Megumi, Kozuma Shiho, Kadokura Michinori, Wakita Kenichi, Hirahara Kazuki, Amano Masato, Watanabe Ichiro, Okamoto Atsushi, Tuettenberg Andrea, Jonuleit Helmut, Tanemura Atsushi, Maruyama Shoichi, Agatsuma Toshinori, Wada Teiji, Nishikawa Hiroyoshi

    CANCER RESEARCH   Vol. 81 ( 13 )   2021.7

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  116. Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity

    Kobayashi Azusa, Ito Ayaka, Shirakawa Ibuki, Tamura Atsushi, Tomono Susumu, Shindou Hideo, Hedde Per Niklas, Tanaka Miyako, Tsuboi Naotake, Ishimoto Takuji, Akashi-Takamura Sachiko, Maruyama Shoichi, Suganami Takayoshi

    FRONTIERS IN IMMUNOLOGY   Vol. 12   page: 650856   2021.6

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  117. C1 inhibitor mitigates peritoneal injury in zymosan-induced peritonitis

    Ozeki Toshikazu, Mizuno Masashi, Iguchi Daiki, Kojima Hiroshi, Kim Hangsoo, Suzuki Yasuhiro, Kinashi Hiroshi, Ishimoto Takuji, Maruyama Shoichi, Ito Yasuhiko

    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY   Vol. 320 ( 6 ) page: F1123 - F1132   2021.6

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  118. Impact of serum magnesium and bone mineral density on systemic fractures in chronic hemodialysis patients

    Hori Mayuko, Yasuda Kaoru, Takahashi Hiroshi, Yamazaki Chikao, Morozumi Kunio, Maruyama Shoichi

    PLOS ONE   Vol. 16 ( 5 ) page: e0251912   2021.5

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  119. DOSE-RESPONSE RELATIONSHIP BETWEEN ALCOHOL CONSUMPTION AND THE RISK OF DEVELOPING CKD: RETROSPECTIVE COHORT STUDY

    Hashimoto Yusaku, Imaizumi Takahiro, Hori Akihiro, Kato Sawako, Yasuda Yoshinari, Maruyama Shoichi

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 36   2021.5

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  120. IMPACT OF ACTIVE VITAMIN D AND CALCIUM PREPARATION ON VASCULAR CALCIFICATION MARKERS IN HEMODIALYSIS PATIENTS WITH HYPOCALCEMIA INDUCED BY CALCIMIMETICS

    Hashimoto Yusaku, Kato Sawako, Tsuboi Masato, Kuro-O Makoto, Kuwatsuka Yachiyo, Ando Masahiko, Maruyama Shoichi

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 36   2021.5

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  121. Relationship between mortality and use of sodium bicarbonate at the time of dialysis initiation: a prospective observational study

    Morooka, H; Yamamoto, J; Tanaka, A; Inaguma, D; Maruyama, S

    BMC NEPHROLOGY   Vol. 22 ( 1 ) page: 118   2021.4

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  122. 10. Diagnosis and Treatment of Nephrotic Syndrome

    Maruyama Shoichi

    Nihon Naika Gakkai Zasshi   Vol. 110 ( Suppl ) page: 110b - 110b   2021.2

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    DOI: 10.2169/naika.110.110b

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  123. Efficacy of favipiravir for an end stage renal disease patient on maintenance hemodialysis infected with novel coronavirus disease 2019

    Koshi, E; Saito, S; Okazaki, M; Toyama, Y; Ishimoto, T; Kosugi, T; Hiraiwa, H; Jingushi, N; Yamamoto, T; Ozaki, M; Goto, Y; Numaguchi, A; Miyagawa, Y; Kato, I; Tetsuka, N; Yagi, T; Maruyama, S

    CEN CASE REPORTS   Vol. 10 ( 1 ) page: 126 - 131   2021.2

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  124. Relationship between selection of dosage forms of vitamin D receptor activators and short-term survival of patients on hemodialysis

    Koshi-Ito Eri, Inaguma Daijo, Koide Shigehisa, Takahashi Kazuo, Hayashi Hiroki, Tsuboi Naotake, Hasegawa Midori, Maruyama Shoichi, Yuzawa Yukio

    RENAL FAILURE   Vol. 43 ( 1 ) page: 1528 - 1538   2021.1

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  125. Development of entrustable professional activities for residents rotating nephrology department in a Japanese university hospital: a Delphi study

    Tanaka Akihito, Kondo Takeshi, Urushibara-Miyachi Yuka, Maruyama Shoichi, Nishigori Hiroshi

    BMJ OPEN   Vol. 11 ( 8 ) page: e047923   2021

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  126. 腎移植後に抗HLA抗体が検出された患者の移植腎機能の検討

    藤田 高史, 石田 昇平, 田中 章仁, 齋藤 尚二, 安田 宣成, 丸山 彰一, 加藤 真史

    移植   Vol. 56 ( Supplement ) page: s152 - s152   2021

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    <p>2018年4月1日から抗体スクリーニング検査および抗体特異性同定検査による抗HLA抗体の測定が保険収載された。当院では2019年から腎移植外来に通院している患者に対して、年に1回の抗体スクリーニング検査の実施を開始した。今回我々はPreformed DSAを有する症例を除く、112例を対象に、抗体スクリーニング検査の結果と移植腎機能について検討した。112例中20例(17.9%)で抗HLA抗体が検出された。すべてnon-DSAであった。抗HLA抗体スクリーニング検査時の血性クレアチニン値は抗HLA抗体陰性例では平均1.27mg/dl、抗体陽性例では1.48mg/dlで有意差を認めた(p=0.022)。eGFRは抗体陰性例で46.5ml/min/1.73㎡、抗体陽性例で39.3ml/min/1.73㎡で有意差を認めた(p=0.015)。検出された抗HLA抗体は6例でClassⅠ、14例でClassⅡであったが、二群間で移植腎機能に有意差を認めなかった。non-DSAのみが検出された場合では治療介入の必要性は明確ではないが、特に注意して経過観察する必要がある。</p>

    DOI: 10.11386/jst.56.supplement_s152

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  127. Development of a Comprehensive Chronic Kidney Disease Database and Its Expansion and Enhancement of Connectivity

    KASHIHARA NAOKI, OKADA MIHOKO, YOKOYAMA HITOSHI, NANGAKU MASAOMI, YAMAGATA KUNIHIRO, WADA TAKASHI, NAKASHIMA NAOKI, SUGIYAMA HITOSHI, MARUYAMA SHOICHI, OKADA HIROKAZU, KANDA EIICHIRO, KATAOKA HIROMI

    Japan Journal of Medical Informatics   Vol. 40 ( 1 ) page: 20 - 21   2020.9

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    DOI: 10.14948/jami.40.20

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  128. A nationwide cross-sectional analysis of thrombotic microangiopathy in the Japan Renal Biopsy Registry (J-RBR).

    Katsuno T, Ito Y, Kagami S, Kitamura H, Maruyama S, Shimizu A, Sugiyama H, Sato H, Yokoyama H, Kashihara N

    Clinical and experimental nephrology   Vol. 24 ( 9 ) page: 789 - 797   2020.9

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    DOI: 10.1007/s10157-020-01896-7

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  129. Additional prognostic value of toe-brachial index beyond ankle-brachial index in hemodialysis patients

    Hishida, M; Imaizumi, T; Menez, S; Okazaki, M; Akiyama, S; Kasuga, H; Ishigami, J; Maruyama, S; Matsushita, K

    BMC NEPHROLOGY   Vol. 21 ( 1 ) page: 353   2020.8

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  130. Progress in Diagnosis and Treatment of Glomerulonephritis・Nephrotic Syndrome

    Maruyama Shoichi

    Nihon Naika Gakkai Zasshi   Vol. 109 ( 5 ) page: 877 - 880   2020.5

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    DOI: 10.2169/naika.109.877

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  131. Therapeutic Application of Adipose Derived Mesenchymal Stem Cells for Kidney Diseases

    Furuhashi Kazuhiro, Maruyama Shoichi

    Nihon Naika Gakkai Zasshi   Vol. 109 ( 4 ) page: 812 - 818   2020.4

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    DOI: 10.2169/naika.109.812

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  132. クロスマッチ陽性生体腎移植の臨床的検討

    藤田 高史, 栃木 宏介, 石田 昇平, 舟橋 康人, 松川 宜久, 田中 章仁, 齋藤 尚二, 安田 宣成, 丸山 彰一, 加藤 真史

    移植   Vol. 55 ( Supplement ) page: 397_1 - 397_1   2020

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    <p>DSAは抗体関連型拒絶反応のリスク因子であり、①CDC陽性②FCXM陽性③FCXM陰性でDSA陽性の順にDSAの力価が高いと考えられている。クロスマッチ陽性腎移植における脱感作療法後のAMR発生率は12-60%と報告されているが、DSAの力価によりAMRの発生率は異なる。今回われわれは2011年から2019年までに当院で施行された生体腎移植の77例を対象として、FCXM陽性(グループ①、26例)、FCXM陰性でDSA陽性(グループ②、3例)、FCXM陰性(グループ③、48例)に分けて拒絶反応の発生率、CMV抗原血症、生着率について検討した。輸血、妊娠、移植の感作歴はグループ①、②、③でそれぞれ53.8%、33.3%、20.8%、DSAはグループ①に3例、グループ②に3例確認された。脱感作療法としてリツキシマブはグループ①、②、③でそれぞれ65.4%、100%、35.4%に投与されていた。AMRの発生率はグループ①、②、③でそれぞれ15.4%、33.3%、2.1%であった。CMV抗原血症に対してVGCの投与を要した症例はグループ①、②、③でそれぞれ15.3%、33.3%、29.2%であった。3年生着率はグループ①、②、③でそれぞれ100%、100%、92.4%であった。FCXM陽性例およびDSA陽性例はFCXM陰性例に比較するとAMRの発生率は高いが、短期生着率に差は認めなかった。</p>

    DOI: 10.11386/jst.55.supplement_397_1

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  133. Clinical Impact of Urinary CD11b and CD163 on the Renal Outcomes of Anti-neutrophil Cytoplasmic Antibody-Associated Glomerulonephritis Reviewed

    坪井 直毅, 勝野 敬之, 丸山 彰一

    Nephrol Dial Transplant.   Vol. -   2020

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  134. 特集 腎生検から病因と病態を読む 腎臓病の分類 形態分類から病因分類へ J-RBR登録項目の改訂について

    尾関 貴哉, 丸山 彰一

    腎と透析   Vol. 87 ( 4 ) page: 534 - 545   2019.10

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    DOI: 10.24479/j00714.2020026541

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  135. Relationship between dietary non-enzymatic antioxidant capacity and type 2 diabetes risk in the Japan Public Health Center-based Prospective Study

    Kashino, I; Serafini, M; Kurotani, K; Akter, S; Mizoue, T; Ishihara, J; Kotemori, A; Sawada, N; Inoue, M; Iwasaki, M; Noda, M; Tsugane, S; Tsugane, S; Sawada, N; Iwasaki, M; Sasazuki, S; Yamaji, T; Shimazu, T; Hanaoka, T; Ogata, J; Baba, S; Mannami, T; Okayama, A; Kokubo, Y; Miyakawa, K; Saito, F; Koizumi, A; Sano, Y; Hashimoto, I; Ikuta, T; Tanaba, Y; Sato, H; Roppongi, Y; Takashima, T; Suzuki, H; Miyajima, Y; Suzuki, N; Nagasawa, S; Furusugi, Y; Nagai, N; Ito, Y; Komatsu, S; Minamizono, T; Sanada, H; Hatayama, Y; Kobayashi, F; Uchino, H; Shirai, Y; Kondo, T; Sasaki, R; Watanabe, Y; Miyagawa, Y; Kobayashi, Y; Machida, M; Kobayashi, K; Tsukada, M; Kishimoto, Y; Takara, E; Fukuyama, T; Kinjo, M; Irei, M; Sakiyama, H; Imoto, K; Yazawa, H; Seo, T; Seiko, A; Ito, F; Shoji, F; Saito, R; Murata, A; Minato, K; Motegi, K; Fujieda, T; Yamato, S; Matsui, K; Abe, T; Katagiri, M; Suzuki, M; Niigata, KM; Doi, M; Terao, A; Ishikawa, Y; Tagami, T; Sueta, H; Doi, H; Urata, M; Okamoto, N; Ide, F; Goto, H; Fujita, R; Onga, N; Takaesu, H; Uehara, M; Nakasone, T; Yamakawa, M; Horii, F; Asano, I; Yamaguchi, H; Aoki, K; Maruyama, S; Ichii, M; Takano, M; Tsubono, Y; Suzuki, K; Honda, Y; Yamagishi, K; Sakurai, S; Tsuchiya, N; Kabuto, M; Yamaguchi, M; Matsumura, Y; Sasaki, S; Watanabe, S; Akabane, M; Kadowaki, T; Inoue, M; Noda, M; Mizoue, T; Kawaguchi, Y; Takashima, Y; Yoshida, Y; Nakamura, K; Takachi, R; Ishihara, J; Matsushima, S; Natsukawa, S; Shimizu, H; Sugimura, H; Tominaga, S; Hamajima, N; Iso, H; Sobue, T; Iida, M; Ajiki, W; Ioka, A; Sato, S; Maruyama, E; Konishi, M; Okada, K; Saito, I; Yasuda, N; Kono, S; Akiba, S; Isobe, T; Sato, Y

    NUTRITION   Vol. 66   page: 62 - 69   2019.10

  136. Rationale and study design of a randomized controlled trial for development of a treatment strategy for chronic kidney disease-mineral and bone disorder by multilateral mechanism of etelcalcetide hydrochloride (the DUET study)

    Kato, S; Tsuboi, M; Ando, M; Itano, Y; Maruyama, S

    RENAL REPLACEMENT THERAPY   Vol. 5 ( 1 )   2019.9

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    DOI: 10.1186/s41100-019-0236-5

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  137. Chronological change of renal pathological findings in the proliferative glomerulonephritis with monoclonal IgG deposits considered to have recurred early after kidney transplantation

    Katsuno Takayuki, Kato Masashi, Fujita Takashi, Tsuboi Naotake, Hattori Ryohei, Ito Yasuhiko, Maruyama Shoichi

    CEN CASE REPORTS   Vol. 8 ( 3 ) page: 151 - 158   2019.8

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    DOI: 10.1007/s13730-019-00384-6

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  138. Evaluating a New International Risk-Prediction Tool in IgA Nephropathy

    Barbour, SJ; Coppo, R; Zhang, H; Liu, ZH; Suzuki, Y; Matsuzaki, K; Katafuchi, R; Er, L; Espino-Hernandez, G; Kim, SJ; Reich, HN; Feehally, J; Cattran, DC; Russo, ML; Troyanov, S; Cook, HT; Roberts, I; Tesar, V; Maixnerova, D; Lundberg, S; Gesualdo, L; Emma, F; Fuiano, L; Beltrame, G; Rollino, C; Amore, A; Camilla, R; Peruzzi, L; Praga, M; Feriozzi, S; Polci, R; Segoloni, G; Colla, L; Pani, A; Piras, D; Angioi, A; Cancarini, G; Ravera, S; Durlik, M; Moggia, E; Ballarin, J; Di Giulio, S; Pugliese, F; Serriello, I; Caliskan, Y; Sever, M; Kilicaslan, I; Locatelli, F; Del Vecchio, L; Wetzels, JFM; Peters, H; Berg, U; Carvalho, F; Ferreira, ACD; Maggio, M; Wiecek, A; Ots-Rosenberg, M; Magistroni, R; Topaloglu, R; Bilginer, Y; D'Amico, M; Stangou, M; Giacchino, F; Goumenos, D; Kalliakmani, P; Gerolymos, M; Galesic, K; Geddes, C; Siamopoulos, K; Balafa, O; Galliani, M; Stratta, P; Quaglia, M; Bergia, R; Cravero, R; Salvadori, M; Cirami, L; Fellstrorn, B; Smerud, HK; Ferrario, F; Stellato, T; Egido, J; Martin, C; Floege, J; Eitner, F; Lupo, A; Bernich, P; Menè, R; Morosetti, M; van Kooten, C; Rabelink, T; Reinders, MEJ; Grinyo, JMB; Cusinato, S; Benozzi, L; Savoldi, S; Licata, C; Mizerska-Wasiak, M; Martina, G; Messuerotti, A; Dal Canton, A; Esposito, C; Migotto, C; Triolo, G; Mariano, F; Pozzi, C; Boero, R; Bellur, S; Mazzucco, G; Giannakakis, C; Honsova, E; Sundelin, B; Di Palma, AM; Ferrario, F; Gutiérrez, E; Asunis, AM; Barratt, J; Tardanico, R; Perkowska-Ptasinska, A; Terroba, JA; Fortunato, M; Pantzaki, A; Ozluk, Y; Steenbergen, E; Soderberg, M; Riispere, Z; Furci, L; Orhan, D; Kipgen, D; Casartelli, D; Ljubanovic, DG; Gakiopoulou, H; Bertoni, E; Ortiz, PC; Karkoszka, H; Groene, HJ; Stoppacciaro, A; Bajema, I; Bruijn, J; Oliveras, XF; Maldyk, J; Loachim, E; Bavbek, N; Cook, T; Troyanov, S; Alpers, C; Amore, A; Barratt, J; Berthoux, F; Bonsib, S; Bruijn, J; D'Agati, V; D'Amico, G; Emancipator, S; Emmal, F; Ferrario, F; Fervenza, F; Florquin, S; Fogo, A; Geddes, C; Groene, H; Haas, M; Hill, P; Hogg, R; Hsu, S; Hunley, T; Hladunewich; Jennette, C; Joh, K; Julian, B; Kawamura, T; Lai, F; Leung, C; Li, L; Li, P; Liu, Z; Massat, A; Mackinnon, B; Mezzano, S; Schena, F; Tomino, Y; Walker, P; Wang, H; Weening, J; Yoshikawa, N; Zeng, CH; Shi, SF; Nogi, C; Suzuki, H; Koike, K; Hirano, K; Kawamura, T; Yokoo, T; Hanai, M; Fukami, K; Takahashi, K; Yuzawa, Y; Niwa, M; Yasuda, Y; Maruyama, S; Ichikawa, D; Suzuki, T; Shirai, S; Fukuda, A; Fujimoto, S; Trimarchi, H

    JAMA INTERNAL MEDICINE   Vol. 179 ( 7 ) page: 942 - 952   2019.7

  139. Clinical impact of endocapillary proliferation with modified cutoff points in IgA nephropathy patients

    Kaihan Ahmad Baseer, Yasuda Yoshinari, Imaizumi Takahiro, Inagaki Koji, Ozeki Takaya, Hishida Manabu, Katsuno Takayuki, Tsuboi Naotake, Maruyama Shoichi

    PLOS ONE   Vol. 14 ( 3 ) page: e0214414   2019.3

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  140. Urinary levels of the leukocyte surface molecule CD11b associate with glomerular inflammation in lupus nephritis

    Kitagawa Akimitsu, Tsuboi Naotake, Yokoe Yuki, Katsuno Takayuki, Ikeuchi Hidekazu, Kajiyama Hiroshi, Endo Nobuhide, Sawa Yuriko, Suwa Junya, Sugiyama Yutaka, Hachiya Asaka, Mimura Toshihide, Hiromura Keiju, Maruyama Shoichi

    KIDNEY INTERNATIONAL   Vol. 95 ( 3 ) page: 680 - 692   2019.3

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    DOI: 10.1016/j.kint.2018.10.025

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  141. Therapeutic efficacy of rituximab for the management of adult-onset steroid-dependent nephrotic syndrome: a retrospective study.

    Katsuno T, Masuda T, Saito S, Kato N, Ishimoto T, Kato S, Kosugi T, Tsuboi N, Kitamura H, Tsuzuki T, Ito Y, Maruyama S

    Clinical and experimental nephrology   Vol. 23 ( 2 ) page: 207 - 214   2019.2

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    DOI: 10.1007/s10157-018-1630-y

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  142. Safety and effectiveness of eculizumab for pediatric patients with atypical hemolytic-uremic syndrome in Japan: interim analysis of post-marketing surveillance.

    Ito S, Hidaka Y, Inoue N, Kaname S, Kato H, Matsumoto M, Miyakawa Y, Mizuno M, Okada H, Shimono A, Matsuda T, Maruyama S, Fujimura Y, Nangaku M, Kagami S

    Clinical and experimental nephrology   Vol. 23 ( 1 ) page: 112 - 121   2019.1

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    DOI: 10.1007/s10157-018-1610-2

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  143. Differences in peritoneal solute transport rates in peritoneal dialysis.

    Asano M, Ishii T, Hirayama A, Mizuno M, Suzuki Y, Sakata F, Akiyama SI, Maruyama S, Soga T, Kinashi H, Katsuno T, Ito Y

    Clinical and experimental nephrology   Vol. 23 ( 1 ) page: 122 - 134   2019.1

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    DOI: 10.1007/s10157-018-1611-1

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  144. Safety and effectiveness of eculizumab for adult patients with atypical hemolytic-uremic syndrome in Japan: interim analysis of post-marketing surveillance.

    Kato H, Miyakawa Y, Hidaka Y, Inoue N, Ito S, Kagami S, Kaname S, Matsumoto M, Mizuno M, Matsuda T, Shimono A, Maruyama S, Fujimura Y, Nangaku M, Okada H

    Clinical and experimental nephrology   Vol. 23 ( 1 ) page: 65 - 75   2019.1

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    DOI: 10.1007/s10157-018-1609-8

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  145. Menstrual and reproductive factors and type 2 diabetes risk: The Japan Public Health Center-based Prospective Study

    Nanri, A; Mizoue, T; Noda, M; Goto, A; Sawada, N; Tsugane, S; Tsugane, S; Sawada, N; Iwasaki, M; Inoue, M; Yamaji, T; Goto, A; Shimazu, T; Charvat, H; Budhathoki, S; Muto, M; Suzuki, H; Minamizono, T; Kobayashi, Y; Irei, M; Doi, M; Katagiri, M; Tagami, T; Sou, Y; Uehara, M; Kokubo, Y; Yamagishi,; Noda, M; Mizoue, T; Kawaguchi, Y; Nakamura, K; Takachi, R; Ishihara, J; Iso, H; Sobue, T; Saito, I; Yasuda, N; Mimura, M; Sakata, K; Hanaoka, T; Hidaka, A; Sasazuki, S; Ogata, J; Baba, S; Mannami, T; Okayama, A; Miyakawa, K; Saito, F; Koizumi, A; Sano, Y; Hashimoto, I; Ikuta, T; Tanaba, Y; Sato, H; Roppongi, Y; Takashima, T; Miyajima, Y; Suzuki, N; Nagasawa, S; Furusugi, Y; Nagai, N; Ito, Y; Komatsu, S; Sanada, H; Hatayama, Y; Kobayashi, F; Uchino, H; Shirai, Y; Kondo, T; Sasaki, R; Watanabe, Y; Miyagawa, Y; Kobayashi, Y; Machida, M; Kobayashi, K; Tsukada, M; Kishimoto, Y; Takara, E; Fukuyama, T; Kinjo, M; Irei, M; Sakiyama, H; Imoto, K; Yazawa, H; Seo, T; Seiko, A; Ito, F; Shoji, F; Saito, R; Murata, A; Minato, K; Motegi, K; Fujieda, T; Yamato, S; Matsui, K; Abe, T; Katagiri, M; Suzuki, M; Doi, M; Tera, A; Ishikawa, Y; Sueta, H; Doi, H; Urata, M; Okamoto, N; Ide, F; Goto, H; Fujita, R; Sakiyama, H; Onga, N; Takaesu, H; Uehara, M; Nakasone, T; Yamakawa, M; Horii, F; Asano, I; Yamaguchi, H; Aoki, K; Maruyama, S; Ichii, M; Takano, M; Tsubono, Y; Suzuki, K; Honda, Y; Sakurai, S; Tsuchiya, N; Kabuto, M; Yamaguchi, M; Matsumura, Y; Sasaki, S; Watanabe, S; Akabane, M; Kadowaki, T; Takashima, Y; Yoshida, Y; Matsushima, S; Natsukawa, S; Sugimura, H; Tominaga, S; Iida, M; Ajiki, W; Ioka, A; Sato, S; Konishi, M; Okada, K; Hamajima, N; Akiba, S; Isobe, T; Sato, Y; Shimizu, H; Kono, S; Sobue, T; Maruyama, E

    JOURNAL OF DIABETES INVESTIGATION   Vol. 10 ( 1 ) page: 147 - 153   2019.1

  146. Changes in Smoking Status and Mortality From All Causes and Lung Cancer: A Longitudinal Analysis of a Population-based Study in Japan

    Zha, L; Sobue, T; Kitamura, T; Kitamura, Y; Sawada, N; Iwasaki, M; Sasazuki, S; Yamaji, T; Shimazu, T; Tsugane, S; Tsugane, S; Sawada, N; Iwasaki, M; Sasazuki, S; Yamaji, T; Shimazu, T; Goto, A; Hidaka, A; Hanaoka, T; Ogata, J; Baba, S; Mannami, T; Okayama, A; Kokubo, Y; Miyakawa, K; Saito, F; Koizumi, A; Sano, Y; Hashimoto, I; Ikuta, T; Tanaba, Y; Sato, H; Roppongi, Y; Takashima, T; Suzuki, H; Miyajima, Y; Suzuki, N; Nagasawa, S; Furusugi, Y; Nagai, N; Ito, Y; Komatsu, S; Minamizono, T; Sanada, H; Hatayama, Y; Kobayashi, F; Uchino, H; Shirai, Y; Kondo, T; Sasaki, R; Watanabe, Y; Miyagawa, Y; Kobayashi, Y; Machida, M; Kobayashi, K; Tsukada, M; Kishimoto, Y; Takara, E; Fukuyama, T; Kinjo, M; Irei, M; Sakiyama, H; Imoto, K; Yazawa, H; Seo, T; Seiko, A; Ito, F; Shoji, F; Saito, R; Murata, A; Minato, K; Motegi, K; Fujieda, T; Yamato, S; Doi, M; Matsui, K; Abe, T; Katagiri, M; Suzuki, M; Terao, A; Ishikawa, Y; Tagami, T; Sueta, H; Doi, H; Urata, M; Okamoto, N; Ide, F; Goto, H; Fujita, R; Sou, Y; Onga, N; Takaesu, H; Uehara, M; Nakasone, T; Yamakawa, M; Horii, F; Asano, I; Yamaguchi, H; Aoki, K; Maruyama, S; Ichii, M; Takano, M; Tsubono, Y; Suzuki, K; Honda, Y; Yamagishi, K; Sakurai, S; Tsuchiya, N; Kabuto, M; Yamaguchi, M; Matsumura, Y; Sasaki, S; Watanabe, S; Akabane, M; Kadowaki, T; Inoue, M; Noda, M; Mizoue, T; Kawaguchi, Y; Takashima, Y; Yoshida, Y; Nakamura, K; Takachi, R; Ishihara, J; Matsushima, S; Natsukawa, S; Shimizu, H; Sugimura, H; Tominaga, S; Hamajima, N; Iso, H; Sobue, T; Iida, M; Ajiki, W; Ioka, A; Sato, S; Maruyama, E; Konishi, M; Okada, K; Saito, I; Yasuda, N; Kono, S; Akiba, S; Isobe, T; Sato, Y

    JOURNAL OF EPIDEMIOLOGY   Vol. 29 ( 1 ) page: 11 - 17   2019

  147. Tonsillectomy in IgA Nephropathy: A Nationwide Cohort Study in Japan Reviewed International coauthorship

    安田 宜成, 丸山 彰一

    JAMA Network Open   Vol. -   2019

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  148. Anti-C5a complementary peptide mitigates zymosan-induced severe peritonitis with fibrotic encapsulation in rat pretreated with methylglyoxal.

    Iguchi D, Mizuno M, Suzuki Y, Sakata F, Maruyama S, Okada A, Okada H, Ito Y

    American journal of physiology. Renal physiology   Vol. 315 ( 6 ) page: F1732 - F1746   2018.12

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    DOI: 10.1152/ajprenal.00172.2018

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  149. Investigation on the benefits of mycophenolate mofetil and therapeutic drug monitoring in the treatment of Japanese patients with lupus nephritis.

    Katsuno T, Ozaki T, Ozeki T, Hachiya A, Kim H, Kato N, Ishimoto T, Kato S, Kosugi T, Tsuboi N, Mizuno M, Ito Y, Maruyama S

    Clinical and experimental nephrology   Vol. 22 ( 6 ) page: 1341 - 1350   2018.12

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    DOI: 10.1007/s10157-018-1590-2

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  150. Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial.

    Kimura K, Hosoya T, Uchida S, Inaba M, Makino H, Maruyama S, Ito S, Yamamoto T, Tomino Y, Ohno I, Shibagaki Y, Iimuro S, Imai N, Kuwabara M, Hayakawa H, Ohtsu H, Ohashi Y, FEATHER Study Investigators.

    American journal of kidney diseases : the official journal of the National Kidney Foundation   Vol. 72 ( 6 ) page: 798 - 810   2018.12

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    DOI: 10.1053/j.ajkd.2018.06.028

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  151. Chronic Inflammatory Demyelinating Polyneuropathy With Concurrent Membranous Nephropathy: An Anti-paranode and Podocyte Protein Antibody Study and Literature Survey

    Hashimoto Yu, Ogata Hidenori, Yamasaki Ryo, Sasaguri Takakazu, Ko Senri, Yamashita Kenichiro, Xu Zhang, Matsushita Takuya, Tateishi Takahisa, Akiyama Shin'ichi, Maruyama Shoichi, Yamamoto Akifumi, Kira Jun-ichi

    FRONTIERS IN NEUROLOGY   Vol. 9   page: 997   2018.11

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    DOI: 10.3389/fneur.2018.00997

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  152. Thrombotic microangiopathy on kidney biopsy in a patient with TAFRO syndrome.

    Ozeki T, Tsuji M, Yamamoto J, Shigematsu C, Maruyama S

    CEN case reports   Vol. 7 ( 2 ) page: 243 - 247   2018.11

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    DOI: 10.1007/s13730-018-0338-x

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  153. Renoprotective effects of topiroxostat for hyperuremic patients with overt diabetic nephropathy study (ETUDE Study): A prospective, randomized, multicenter clinical trial.

    Mizukoshi T, Kato S, Ando M, Sobajima H, Ohashi N, Naruse T, Saka Y, Shimizu H, Nagata T, Maruyama S

    Nephrology (Carlton, Vic.)   Vol. 23 ( 11 ) page: 1023 - 1030   2018.11

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    DOI: 10.1111/nep.13177

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  154. Smoking Is a Risk Factor for Relapse of Antimyeloperoxidase Antibodies-Associated Vasculitis.

    Yamaguchi M, Ando M, Katsuno T, Tsuboi N, Maruyama S

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases   Vol. 24 ( 7 ) page: 361 - 367   2018.10

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    DOI: 10.1097/RHU.0000000000000737

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  155. Extracellular histones decrease the expression of membrane complement regulators

    Mizuno Tomohiro, Nagano Fumihiko, Mizuno Masashi, Iwata Ayumi, Takahashi Kazuo, Tsuboi Naotake, Maruyama Shoichi, Nagamatsu Tadashi, Imai Masaki

    MOLECULAR IMMUNOLOGY   Vol. 102   page: 189 - 189   2018.10

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    DOI: 10.1016/j.molimm.2018.06.158

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  156. Peritoneal expression of membrane complement regulators in peritoneal dialysis patients with fungal peritonitis

    Fukui Sosuke, Suzuki Yasuhiro, Tawada Mitsuhiro, Matsukawa Yoshihisa, Imai Masaki, Maruyama Shoichi, Ito Yasuhiko, Mizuno Masashi

    MOLECULAR IMMUNOLOGY   Vol. 102   page: 152 - 152   2018.10

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    DOI: 10.1016/j.molimm.2018.06.072

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  157. Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cell, but not Adipose Tissue-Derived Stem Cell, Ameliorated the Neonatal Hypoxic-Ischemic Brain Injury by Changing Cerebral Inflammatory State in Rat

    Sugiyama Yuichiro, Sato Yoshiaki, Kitase Yuma, Suzuki Toshihiko, Kondo Taiki, Mikrogeorgiou Alkisti, Horinouchi Asuka, Maruyama Shoichi, Shimoyama Yoshie, Tsuji Masahiro, Suzuki Satoshi, Yamamoto Tokunori, Hayakawa Masahiro

    FRONTIERS IN NEUROLOGY   Vol. 9   page: 757   2018.9

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    DOI: 10.3389/fneur.2018.00757

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  158. Clinical impact of endocapillary proliferation according to the Oxford classification among adults with Henoch- Schonlein purpura nephritis: a multicenter retrospective cohort study

    Inagaki Koji, Kaihan Ahmad Baseer, Hachiya Asaka, Ozeki Takaya, Ando Masahiko, Kato Sawako, Yasuda Yoshinari, Maruyama Shoichi

    BMC NEPHROLOGY   Vol. 19 ( 1 ) page: 208   2018.8

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    DOI: 10.1186/s12882-018-1009-z

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  159. CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease

    Maeda Kayaho, Otomo Kotaro, Yoshida Nobuya, Abu-Asab Mones S., Ichinose Kunihiro, Nishino Tomoya, Kono Michihito, Ferretti Andrew, Bhargava Rhea, Maruyama Shoichi, Bickerton Sean, Fahmy Tarek M., Tsokos Maria G., Tsokos George C.

    JOURNAL OF CLINICAL INVESTIGATION   Vol. 128 ( 8 ) page: 3445 - 3459   2018.8

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    DOI: 10.1172/JCI99507

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  160. The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases

    Mori Yoshiko, Masuda Tomohiro, Kosugi Tomoki, Yoshioka Tomoki, Hori Mayuko, Nagaya Hiroshi, Maeda Kayaho, Sato Yuka, Kojima Hiroshi, Kato Noritoshi, Ishimoto Takuji, Katsuno Takayuki, Yuzawa Yukio, Kadomatsu Kenji, Maruyama Shoichi

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 22 ( 4 ) page: 815 - 824   2018.8

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    DOI: 10.1007/s10157-017-1518-2

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  161. A consensus statement on health-care transition of patients with childhood-onset chronic kidney diseases: providing adequate medical care in adolescence and young adulthood

    Kubota Wataru, Honda Masataka, Okada Hirokazu, Hattori Motoshi, Iwano Masayuki, Akioka Yuko, Ashida Akira, Kawasaki Yukihiko, Kiyomoto Hideyasu, Sako Mayumi, Terada Yoshio, Hirano Daishi, Fujieda Mikiya, Fujimoto Shouichi, Masaki Takao, Ito Shuichi, Uemura Osamu, Gotoh Yoshimitsu, Komatsu Yasuhiro, Nishi Shinichi, Maru Mitsue, Narita Ichiei, Maruyama Shoichi

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 22 ( 4 ) page: 743 - 751   2018.8

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    DOI: 10.1007/s10157-018-1589-8

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  162. Lacking ketohexokinase-A exacerbates renal injury in streptozotocin-induced diabetic mice.

    Doke T, Ishimoto T, Hayasaki T, Ikeda S, Hasebe M, Hirayama A, Soga T, Kato N, Kosugi T, Tsuboi N, Lanaspa MA, Johnson RJ, Kadomatsu K, Maruyama S

    Metabolism: clinical and experimental   Vol. 85   page: 161 - 170   2018.8

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    DOI: 10.1016/j.metabol.2018.03.020

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  163. Clinical features and pathogenesis of membranoproliferative glomerulonephritis: a nationwide analysis of the Japan renal biopsy registry from 2007 to 2015

    Nakagawa Naoki, Hasebe Naoyuki, Hattori Motoshi, Nagata Michio, Yokoyama Hitoshi, Sato Hiroshi, Sugiyama Hitoshi, Shimizu Akira, Isaka Yoshitaka, Maruyama Shoichi, Narita Ichiei

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 22 ( 4 ) page: 797 - 807   2018.8

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    DOI: 10.1007/s10157-017-1513-7

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  164. Urinary protein and renal prognosis in idiopathic membranous nephropathy: a multicenter retrospective cohort study in Japan

    Yamaguchi Makoto, Ando Masahiko, Katsuno Takayuki, Tsuboi Naotake, Maruyama Shoichi

    RENAL FAILURE   Vol. 40 ( 1 ) page: 435 - 441   2018.7

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    DOI: 10.1080/0886022X.2018.1487864

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  165. Treatment patterns and steroid dose for adult minimal change disease relapses: A retrospective cohort study

    Ozeki Takaya, Ando Masahiko, Yamaguchi Makoto, Katsuno Takayuki, Kato Sawako, Yasuda Yoshinari, Tsuboi Naotake, Maruyama Shoichi

    PLOS ONE   Vol. 13 ( 6 ) page: e0199228   2018.6

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    DOI: 10.1371/journal.pone.0199228

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  166. THE DURATION FROM THE RECOGNITION OF SHOCK TO THE INITIATION OF PMX-DHP IS A CRITICAL DETERMINANT OF SURVIVAL IN PATIENTS WITH SEPTIC SHOCK

    Funahashi Yoshio, Kato Noritoshi, Ozeki Takaya, Kobayashi Azusa, Oishi Hideto, Maruyama Shoichi

    SHOCK   Vol. 49 ( 6 ) page: 68 - 68   2018.6

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  167. MIR-146A TARGETING SPLENIC MACROPHAGES PREVENTS SEPSIS-INDUCED MULTIPLE ORGAN INJURY INCLUDING ACUTE KIDNEY INJURY

    Funahashi Yoshio, Kato Noritoshi, Kitai Hiroki, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Matsuda Naoyuki, Maruyama Shoichi, Kadomatsu Kenji

    SHOCK   Vol. 49 ( 6 ) page: 21 - 21   2018.6

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  168. Rationale and study design of a clinical trial to assess the effects of LDL apheresis on proteinuria in diabetic patients with severe proteinuria and dyslipidemia

    Wada Takashi, Muso Eri, Maruyama Shoichi, Hara Akinori, Furuichi Kengo, Yoshimura Kenichi, Miyazaki Mariko, Sato Eiichi, Abe Masanori, Shibagaki Yugo, Narita Ichiei, Yokoyama Hitoshi, Mori Noriko, Yuzawa Yukio, Matsubara Takeshi, Tsukamoto Tatsuo, Wada Jun, Ito Takafumi, Masutani Kosuke, Tsuruya Kazuhiko, Fujimoto Shoichi, Tsuda Akihiro, Suzuki Hitoshi, Kasuno Kenji, Terada Yoshio, Nakata Takeshi, Iino Noriaki, Kobayashi Shuzo

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 22 ( 3 ) page: 591 - 596   2018.6

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    DOI: 10.1007/s10157-017-1488-4

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  169. Distinct characteristics and outcomes in elderly-onset IgA vasculitis (Henoch-Schonlein purpura) with nephritis: Nationwide cohort study of data from the Japan Renal Biopsy Registry (J-RBR)

    Komatsu Hiroyuki, Fujimoto Shouichi, Maruyama Shoichi, Mukoyama Masashi, Sugiyama Hitoshi, Tsuruya Kazuhiko, Sato Hiroshi, Soma Jun, Yano Junko, Itano Seiji, Nishino Tomoya, Sato Toshinobu, Narita Ichiei, Yokoyama Hitoshi

    PLOS ONE   Vol. 13 ( 5 ) page: e0196955   2018.5

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    DOI: 10.1371/journal.pone.0196955

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  170. Chondroitin sulfate protects vascular endothelial cells from toxicities of extracellular histones

    Nagano Fumihiko, Mizuno Tomohiro, Mizumoto Shuji, Yoshioka Kengo, Takahashi Kazuo, Tsuboi Naotake, Maruyama Shoichi, Yamada Shuhei, Nagamatsu Tadashi

    EUROPEAN JOURNAL OF PHARMACOLOGY   Vol. 826   page: 48 - 55   2018.5

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    DOI: 10.1016/j.ejphar.2018.02.043

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  171. URINARY CD11B, AN ALPHA SUBUNIT OF INTEGRIN MAC-1, ASSOCIATES WITH HISTOLOGICAL DISEASE ACTIVITY IN LUPUS NEPHRITIS

    Kitagawa Akimitsu, Tsuboi Naotake, Katsuno Takayuki, Maruyama Shoichi

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 33   page: .   2018.5

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  172. SODIUM RESTRICTED DIET DURING CONSERVATIVE THERAPY IN PATIENTS WITH END-STAGE RENAL DISEASES (ESRD) MAY RESCUE RESIDUAL RENAL FUNCTION (RRF) FOR THE FIRST YEAR AFTER STARTING PERITONEAL DIALYSIS (PD)

    Hiramatsu Tetsuaki, Mizuno Masashi, Nomori Sumiyo, Sakata Fumiko, Suzuki Yasuhiro, Maruyama Shoichi, Yasuhiko Ito, Noguchi Satoshi

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 33   page: .   2018.5

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  173. FRUCTOSE METABOLISM INCREASES BLOOD PRESSURE BY THE UPREGULATION OF RENAL SODIUM REABSORPTION IN MICE

    Hayasaki Takahiro, Ishimoto Takuji, Doke Tomohito, Lanaspa Miguel, Johnson Richard, Maruyama Shoichi

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 33   page: .   2018.5

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  174. Lifestyle intervention using Internet of Things (IoT) for the elderly: A study protocol for a randomized control trial (the BEST-LIFE study)

    Kato Sawako, Ando Masahiko, Kondo Takaaki, Yoshida Yasuko, Honda Hiroyuki, Maruyama Shoichi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 2 ) page: 175 - 182   2018.5

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    DOI: 10.18999/nagjms.80.2.175

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  175. LACKING OF KETOHEXOKINASE AMELIORATED THE RENAL LIPID ACCUMULATION IN HIGH-FAT DIET FED STREPTOZOTOCIN INDUCED DIABETIC MICE

    Doke Tomohito, Ishimoto Takuji, Hayasaki Takahiro, Johnson Richard, Maruyama Shoichi

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 33   page: .   2018.5

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  176. INCREASED MONOCYTE/LYMPHOCYTE RATIO ASSOCIATES WITH INFECTIOUS HOSPITALIZATION IN INCIDENT DIALYSIS PATIENTS

    Kato Sawako, Bengt Lindholm, Yukio Yuzawa, Tsuruta Yoshinari, Maruyama Shoichi

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 33   page: .   2018.5

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  177. Decline in estimated glomerular filtration rate is associated with risk of end-stage renal disease in type 2 diabetes with macroalbuminuria: an observational study from JDNCS

    Shimizu Miho, Furuichi Kengo, Toyama Tadashi, Funamoto Tomoaki, Kitajima Shinji, Hara Akinori, Ogawa Daisuke, Koya Daisuke, Ikeda Kenzo, Koshino Yoshitaka, Kurokawa Yukie, Abe Hideharu, Mori Kiyoshi, Nakayama Masaaki, Konishi Yoshio, Samejima Ken-ichi, Matsui Masaru, Yamauchi Hiroyuki, Gohda Tomohito, Fukami Kei, Nagata Daisuke, Yamazaki Hidenori, Yuzawa Yukio, Suzuki Yoshiki, Fujimoto Shouichi, Maruyama Shoichi, Kato Sawako, Naito Takero, Yoshimura Kenichi, Yokoyama Hitoshi, Wada Takashi

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 22 ( 2 ) page: 377 - 387   2018.4

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    DOI: 10.1007/s10157-017-1467-9

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  178. Unfavorable effects of history of volume overload and late referral to a nephrologist on mortality in patients initiating dialysis: a multicenter prospective cohort study in Japan

    Okazaki Masaki, Inaguma Daijo, Imaizumi Takahiro, Kada Akiko, Yaomura Takaaki, Tsuboi Naotake, Maruyama Shoichi

    BMC NEPHROLOGY   Vol. 19 ( 1 ) page: 65   2018.3

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    DOI: 10.1186/s12882-018-0859-8

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  179. TGF-beta 1-VEGF-A pathway induces neoangiogenesis with peritoneal fibrosis in patients undergoing peritoneal dialysis

    Kariya Tetsuyoshi, Nishimura Hayato, Mizuno Masashi, Suzuki Yasuhiro, Matsukawa Yoshihisa, Sakata Fumiko, Maruyama Shoichi, Takei Yoshifumi, Ito Yasuhiko

    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY   Vol. 314 ( 2 ) page: F167 - F180   2018.2

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    DOI: 10.1152/ajprenal.00052.2017

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  180. Rationale and design of oBservational clinical Research In chronic kidney disease patients with renal anemia: renal proGnosis in patients with Hyporesponsive anemia To Erythropoiesis-stimulating agents, darbepoetiN alfa (BRIGHTEN Trial)

    Kato Hideki, Nangaku Masaomi, Hirakata Hideki, Wada Takashi, Hayashi Terumasa, Sato Hiroshi, Yamazaki Yasushi, Masaki Takao, Kagimura Tatsuo, Yamamoto Hiroyasu, Hase Hiroki, Kamouchi Masahiro, Imai Enyu, Mizuno Kyoichi, Iwasaki Manabu, Akizawa Tadao, Tsubakihara Yoshiharu, Maruyama Shoichi, Narita Ichiei

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 22 ( 1 ) page: 78 - 84   2018.2

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    DOI: 10.1007/s10157-017-1427-4

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  181. Rationale and design of oBservational clinical Research In chronic kidney disease patients with renal anemia: renal proGnosis in patients with Hyporesponsive anemia To Erythropoiesis-stimulating agents, darbepoetiN alfa (BRIGHTEN Trial) (vol 22, pg 78, 2018)

    Kato Hideki, Nangaku Masaomi, Hirakata Hideki, Wada Takashi, Hayashi Terumasa, Sato Hiroshi, Yamazaki Yasushi, Masaki Takao, Kagimura Tatsuo, Yamamoto Hiroyasu, Hase Hiroki, Kamouchi Masahiro, Imai Enyu, Mizuno Kyoichi, Iwasaki Manabu, Akizawa Tadao, Tsubakihara Yoshiharu, Maruyama Shoichi, Narita Ichiei

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 22 ( 1 ) page: 85 - 86   2018.2

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    DOI: 10.1007/s10157-017-1461-2

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  182. Effect of dietary energy and polymorphisms in &ITBRAP&IT and &ITGHRL&IT on obesity and metabolic traits

    Imaizumi Takahiro, Ando Masahiko, Nakatochi Masahiro, Yasuda Yoshinari, Honda Hiroyuki, Kuwatsuka Yachiyo, Kato Sawako, Kondo Takaaki, Iwata Masamitsu, Nakashima Toru, Yasui Hiroshi, Takamatsu Hideki, Okajima Hiroshi, Yoshida Yasuko, Maruyama Shoichi

    OBESITY RESEARCH & CLINICAL PRACTICE   Vol. 12 ( 1 ) page: 39 - 48   2018.1

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    DOI: 10.1016/j.orcp.2016.05.004

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  183. リツキシマブの腎疾患治療への応用

    坪井 直毅, 丸山 彰一

    診断と治療   Vol. 106(4)   2018

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  184. Urinary and circulating levels of the anti-angiogenic isoform of vascular endothelial growth factor-A in patients with chronic kidney disease

    Kikuchi Ryosuke, Yasuda Yoshinari, Nakatochi Masahiro, Shibata Yohei, Hara Toshiaki, Suzuki Atsuo, Imaizumi Takahiro, Suzuki Susumu, Ishii Hideki, Takeshita Kyosuke, Matsushita Tadashi, Maruyama Shoichi, Murohara Toyoaki

    CLINICA CHIMICA ACTA   Vol. 475   page: 102 - 108   2017.12

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    DOI: 10.1016/j.cca.2017.10.014

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  185. The Japanese Histologic Classification and T-score in the Oxford Classification system could predict renal outcome in Japanese IgA nephropathy patients

    Kaihan Ahmad Baseer, Yasuda Yoshinari, Katsuno Takayuki, Kato Sawako, Imaizumi Takahiro, Ozeki Takaya, Hishida Manabu, Nagata Takanobu, Ando Masahiko, Tsuboi Naotake, Maruyama Shoichi

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 21 ( 6 ) page: 986 - 994   2017.12

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    DOI: 10.1007/s10157-017-1393-x

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  186. Mizoribine therapy combined with steroids and mizoribine blood concentration monitoring for idiopathic membranous nephropathy with steroid-resistant nephrotic syndrome

    Saito Takao, Iwano Masayuki, Matsumoto Koichi, Mitarai Tetsuya, Yokoyama Hitoshi, Yorioka Noriaki, Nishi Shinichi, Yoshimura Ashio, Sato Hiroshi, Ogahara Satoru, Sasatomi Yoshie, Kataoka Yasufumi, Ueda Shiro, Koyama Akio, Maruyama Shoichi, Nangaku Masaomi, Imai Enyu, Matsuo Seiichi, Tomino Yasuhiko

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 21 ( 6 ) page: 961 - 970   2017.12

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    DOI: 10.1007/s10157-016-1340-2

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  187. Seasonal proteinuria changes in IgA nephropathy patients after proteinuria remission

    Inagaki Koji, Yasuda Yoshinari, Ando Masahiko, Kaihan Ahmad Baseer, Hachiya Asaka, Ozeki Takaya, Hishida Manabu, Imaizumi Takahiro, Katsuno Takayuki, Kato Sawako, Tsuboi Naotake, Maruyama Shoichi

    PLOS ONE   Vol. 12 ( 11 ) page: e0187607   2017.11

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    DOI: 10.1371/journal.pone.0187607

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  188. Association between kidney function and genetic polymorphisms in atherosclerotic and chronic kidney diseases: A cross-sectional study in Japanese male workers

    Kubo Yoko, Imaizumi Takahiro, Ando Masahiko, Nakatochi Masahiro, Yasuda Yoshinari, Honda Hiroyuki, Kuwatsuka Yachiyo, Kato Sawako, Kikuchi Kyoko, Kondo Takaaki, Iwata Masamitsu, Nakashima Toru, Yasui Hiroshi, Takamatsu Hideki, Okajima Hiroshi, Yoshida Yasuko, Maruyama Shoichi

    PLOS ONE   Vol. 12 ( 10 ) page: e0185476   2017.10

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    DOI: 10.1371/journal.pone.0185476

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  189. Peritoneal eosinophils increase during induction of peritoneal dialysis and may be related to production of C3a in peritoneal dialysate

    Mizuno Masashi, Shigemoto Emi, Kobayashi Kazuma, Iguchi Daiki, Sakata Fumiko, Suzuki Yasuhiro, Maruyama Shoichi, Ito Yasuhiko

    MOLECULAR IMMUNOLOGY   Vol. 89   page: 193 - 193   2017.9

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    DOI: 10.1016/j.molimm.2017.06.195

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  190. Efficacy of urinary midkine as a biomarker in patients with acute kidney injury

    Hayashi Hiroki, Sato Waichi, Kosugi Tomoki, Nishimura Kunihiro, Sugiyama Daisuke, Asano Naoko, Ikematsu Shinya, Komori Kimihiro, Nishiwaki Kimitoshi, Kadomatsu Kenji, Matsuo Seiichi, Maruyama Shoichi, Yuzawa Yukio

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 21 ( 4 ) page: 597 - 607   2017.8

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    DOI: 10.1007/s10157-016-1318-0

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  191. Randomized controlled trial for assessment of Internet of Things system to guide intensive glucose control in diabetes outpatients: Nagoya Health Navigator Study protocol

    Onoue Takeshi, Goto Motomitsu, Kobayashi Tomoko, Tominaga Takashi, Ando Masahiko, Honda Hiroyuki, Yoshida Yasuko, Tosaki Takahiro, Yokoi Hisashi, Kato Sawako, Maruyama Shoichi, Arima Hiroshi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 79 ( 3 ) page: 323 - 329   2017.8

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    DOI: 10.18999/nagjms.79.3.323

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  192. Mesangial proliferative glomerulonephritis in murine malaria parasite, Plasmodium chabaudi AS, infected NC mice

    Yashima Akihito, Mizuno Masashi, Yuzawa Yukio, Shimada Koki, Suzuki Norihiko, Tawada Hideo, Sato Waichi, Tsuboi Naotake, Maruyama Shoichi, Ito Yasuhiko, Matsuo Seiichi, Ohno Tamio

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 21 ( 4 ) page: 589 - 596   2017.8

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    DOI: 10.1007/s10157-016-1339-8

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  193. Apoptosis inhibitor of macrophage ameliorates fungus-induced peritoneal injury model in mice

    Tomita Takako, Arai Satoko, Kitada Kento, Mizuno Masashi, Suzuki Yasuhiro, Sakata Fumiko, Nakano Daisuke, Hiramoto Emiri, Takei Yoshifumi, Maruyama Shoichi, Nishiyama Akira, Matsuo Seiichi, Miyazaki Toru, Ito Yasuhiko

    SCIENTIFIC REPORTS   Vol. 7 ( 1 ) page: 6450   2017.7

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    DOI: 10.1038/s41598-017-06824-6

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  194. Long-term renal survival of gamma 3-heavy chain deposition disease: a case report

    Katsuno Takayuki, Mizuno Shige, Mabuchi Masatsuna, Tsuboi Naotake, Komatsuda Atsushi, Maruyama Shoichi

    BMC NEPHROLOGY   Vol. 18 ( 1 ) page: 239   2017.7

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  195. Association of interactions between dietary salt consumption and hypertension-susceptibility genetic polymorphisms with blood pressure among Japanese male workers

    Imaizumi Takahiro, Ando Masahiko, Nakatochi Masahiro, Maruyama Shoichi, Yasuda Yoshinari, Honda Hiroyuki, Kuwatsuka Yachiyo, Kato Sawako, Kondo Takaaki, Iwata Masamitsu, Nakashima Toru, Yasui Hiroshi, Takamatsu Hideki, Okajima Hiroshi, Yoshida Yasuko, Matsuo Seiichi

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 21 ( 3 ) page: 457 - 464   2017.6

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    DOI: 10.1007/s10157-016-1315-3

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  196. 30% GFR DECLINE WITHIN 2 YEARS WAS EARLIER BUT INSENSITIVE RENAL OUTCOME AMONG CKD PATIENTS INITIATED HEMODIALYSIS: A LONGITUDINAL GFR TRAJECTORY ANALYSIS

    Kaihan Ahmad Baseer, Yasuda Yoshinari, Katsuno Takayuki, Kato Sawako, Imaizumi Takahiro, Ozeki Tkaya, Hishida Manabu, Inagaki Koji, Hachiya Asaka, Tsubio Naotake, Maruyama Shoichi

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 32   page: 133 - 133   2017.5

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  197. INDUCTION OF IMMUNOSUPPRESSIVE MICRO-RNA IN SPLEEN ATTENUATES SEPSIS INDUCED ACUTE KIDNEY INJURY

    Funahashi Yoshio, Kato Noritoshi, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Kadomatsu Kenji, Maruyama Shoichi

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 32   page: .   2017.5

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  198. AGING-ASSOCIATED RENAL DISEASE IN MICE IS DEPENDENT ON FRUCTOKINASE

    Ishimoto Takuji, Roncal-Jimenez Carlos, Lanaspa Miguel, Milagres Tamara, Hernando Ana, Doke Tomohito, Hayasaki Takahiro, Maruyama Shoichi, Johnson Richard

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 32   page: .   2017.5

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  199. THE ANNUAL RATE OF CHANGE IN GERIATRIC NUTRITIONAL RISK INDEX IMPROVES THE PREDICTABILITY OF MORTALITY IN DIALYSIS PATIENTS

    Yasuda Kaoru, Takahashi Hiroshi, Maruyama Shoichi

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 32   page: 369 - 369   2017.5

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  200. Sodium chloride promotes tissue inflammation via osmotic stimuli in subtotal-nephrectomized mice

    Sakata Fumiko, Ito Yasuhiko, Mizuno Masashi, Sawai Akiho, Suzuki Yasuhiro, Tomita Takako, Tawada Mitsuhiro, Tanaka Akio, Hirayama Akiyoshi, Sagara Akihiro, Wada Takashi, Maruyama Shoichi, Soga Tomoyoshi, Matsuo Seiichi, Imai Enyu, Takei Yoshifumi

    LABORATORY INVESTIGATION   Vol. 97 ( 4 ) page: 432 - 446   2017.4

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  201. Growth Factor Midkine Promotes T-Cell Activation through Nuclear Factor of Activated T Cells Signaling and Th1 Cell Differentiation in Lupus Nephritis

    Masuda Tomohiro, Maeda Kayaho, Sato Waichi, Kosugi Tomoki, Sato Yuka, Kojima Hiroshi, Kato Noritoshi, Ishimoto Takuji, Tsuboi Naotake, Uchimura Kenji, Yuzawa Yukio, Maruyama Shoichi, Kadomatsu Kenji

    AMERICAN JOURNAL OF PATHOLOGY   Vol. 187 ( 4 ) page: 740 - 751   2017.4

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    DOI: 10.1016/j.ajpath.2016.12.006

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  202. THE COEXISTENCE OF ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS AND INFECTION-RELATED GLOMERULONEPHRITIS CAUSED BY PULMONARY MYCOBACTERIUM AVIUM COMPLEX INFECTION

    Katsuno Takayuki, Asano Shuichi, Mizuno Shige, Tsuboi Naotake, Ito Yasuhiko, Hasegawa Yoshinori, Maruyama Shoichi

    RHEUMATOLOGY   Vol. 56   page: 75 - 75   2017.3

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  203. A CASE OF RAPIDLY PROGRESSIVE NEPHRITIC SYNDROME AND NEPHROTIC SYNDROME DURING THE TREATMENT OF DERMATOMYOSITIS AND DIABETES

    Sato Naokazu, Katsuno Takayuki, Mori Masayoshi, Saito Shouji, Kato Noritoshi, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Ito Yasuhiko, Maruyama Shouichi

    RHEUMATOLOGY   Vol. 56   page: 75 - 75   2017.3

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  204. Postpartum atypical hemolytic uremic syndrome with complement factor H mutation complicated by reversible cerebrovascular constriction syndrome successfully treated with eculizumab

    Yamaguchi Makoto, Hori Mayuko, Hiroshi Nagaya, Maruyama Shoichi

    THROMBOSIS RESEARCH   Vol. 151   page: 79 - 81   2017.3

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    DOI: 10.1016/j.thromres.2017.01.013

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  205. PAIRED IMMUNOGLOBULIN-LIKE TYPE2 RECEPTOR ALPHA (PILRA) NEGATIVELY REGULATES MOUSE CRESCENTIC GLOMERULONEPHRITIS

    Sugiyama Yutaka, Tsuboi Naotake, Shimamura Yuko, Kitagawa Akimitsu, Kamimura Yutaka, Horinouchi Asuka, Katsuno Takayuki, Maruyama Shoichi

    RHEUMATOLOGY   Vol. 56   page: 81 - 81   2017.3

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  206. HUMAN ADIPOSE-DERIVED STROMAL CELLS AMELIORATE CRESCENTIC GLOMERULONEPHRITIS

    Shimamura Yuko, Kitagawa Akimitsu, Kamimura Yutaka, Sugiyama Yutaka, Horinouchi Asuka, Katsuno Takayuki, Tsuboi Naotake, Maruyama Shoichi

    RHEUMATOLOGY   Vol. 56   page: 81 - 82   2017.3

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  207. Complement component 5 promotes lethal thrombosis

    Mizuno Tomohiro, Yoshioka Kengo, Mizuno Masashi, Shimizu Mie, Nagano Fumihiko, Okuda Tomoyuki, Tsuboi Naotake, Maruyama Shoichi, Nagamatsu Tadashi, Imai Masaki

    SCIENTIFIC REPORTS   Vol. 7   page: 42714   2017.2

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    DOI: 10.1038/srep42714

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  208. 特集 おさらい腎疾患-明日から役立つアプローチの基本 糸球体疾患 ネフローゼ症候群

    石本 卓嗣, 丸山 彰一

    medicina   Vol. 54 ( 2 ) page: 282 - 285   2017.2

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    DOI: 10.11477/mf.1402224603

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  209. High Levels of Soluble C5b-9 Complex in Dialysis Fluid May Predict Poor Prognosis in Peritonitis in Peritoneal Dialysis Patients

    Mizuno Masashi, Suzuki Yasuhiro, Higashide Keiko, Sei Yumi, Iguchi Daiki, Sakata Fumiko, Horie Masanobu, Maruyama Shoichi, Matsuo Seiichi, Morgan B. Paul, Ito Yasuhiko

    PLOS ONE   Vol. 12 ( 1 ) page: e0169111   2017.1

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  210. The Type of Vascular Access and the Incidence of Mortality in Japanese Dialysis Patients

    Ozeki Toshikazu, Shimizu Hideaki, Fujita Yoshiro, Inaguma Daijo, Maruyama Shoichi, Ohyama Yukako, Minatoguchi Shun, Murai Yukari, Terashita Maho, Tagaya Tomoki

    Internal Medicine   Vol. 56 ( 5 ) page: 481 - 485   2017

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    <p><b>Objective </b>The National Kidney Foundation (NKF) Kidney Disease Outcome Quality Initiative (KDOQI) guidelines have recommended the use of arteriovenous fistula (AVF) at the initiation of dialysis. However, there are significant differences in the dialysis environments of Japan and the United States, and there are few people who receive hemodialysis via a central venous catheter (CVC) in Japan. The aim of the present study was to examine the association between the type of vascular access at the initiation of dialysis and the incidence of mortality in Japan. </p><p><b>Methods </b>This study was a prospective, multicenter, cohort study. The data was collected by the Aichi Cohort study of Prognosis in Patients newly initiated into dialysis (AICOPP) in which 18 Japanese tertiary care centers participated. The present study enrolled 1,524 patients who were newly introduced to dialysis (the patients started maintenance dialysis between October 2011 and September 2013). After excluding 183 patients with missing data, 1,341 patients were enrolled. The Cox proportional hazards model was used to evaluate mortality based on the type of vascular access. The types of vascular access were divided into four categories: AVF, arteriovenous graft (AVG), CVC changed to AVF during the course (CAVF), CVC changed to AVG during the course (CAVG). </p><p><b>Results </b>A multivariate analysis revealed that AVG, CAVF and CAVG were associated with a higher risk of mortality in comparison to AVF [hazard ratio (HR), 1.60; p=0.048; HR, 2.26; p=0.003; and HR, 2.45; p=0.001, respectively]. </p><p><b>Conclusion </b>The research proved that the survival rate among patients in whom hemodialysis was initiated with AVF was significantly higher than that in patients in whom hemodialysis was initiated with AVG or CVC. </p>

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  211. Single-dose Rituximab Therapy for Refractory Idiopathic Membranous Nephropathy: A Single-center Experience

    Katsuno Takayuki, Ozaki Takenori, Kim Hangsoo, Kato Noritoshi, Suzuki Yasuhiro, Akiyama Shinichi, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Ito Yasuhiko, Maruyama Shoichi

    Internal Medicine   Vol. 56 ( 13 ) page: 1679 - 1686   2017

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    <p>To date, a recognized treatment for refractory membranous nephropathy (MN) has not been established. Recently, several reports have indicated the efficacy of rituximab as a novel treatment option. However, only a few published accounts exist of rituximab therapy for idiopathic MN (IMN) in the Asian population. We present the cases of three IMN patients who were treated with single-dose rituximab after they showed no response to conventional therapies, including corticosteroids, cyclosporine, cyclophosphamide, mizoribine, and mycophenolate mofetil. Although one case showed no response, a complete or incomplete remission was achieved in the other two cases. Rituximab may therefore be a beneficial treatment option for IMN. </p>

    DOI: 10.2169/internalmedicine.56.7908

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  212. Kidney biopsy guidebook 2020 in Japan

    Ubara Yoshifumi, Kawaguchi Takehiko, Nagasawa Tasuku, Miura Kenichiro, Katsuno Takayuki, Morikawa Takashi, Ishikawa Eiji, Ogura Masao, Matsumura Hideki, Kurayama Ryota, Matsumoto Shinsuke, Marui Yuhji, Hara Shigeo, Maruyama Shoichi, Narita Ichiei, Okada Hirokazu, Tsuruya Kazuhiko

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 25 ( 4 ) page: 325 - 364   2021.4

  213. Importance of lymph node immune responses in MSI-H/dMMR colorectal cancer.

    Inamori K, Togashi Y, Fukuoka S, Akagi K, Ogasawara K, Irie T, Motooka D, Kobayashi Y, Sugiyama D, Kojima M, Shiiya N, Nakamura S, Maruyama S, Suzuki Y, Ito M, Nishikawa H

    JCI insight     2021.3

  214. Vascular endothelial growth factor (VEGF)-A and VEGF-A(165)b are associated with time to remission of granulomatosis with polyangiitis in a nationwide Japanese prospective cohort study

    Kikuchi Ryosuke, Tsuboi Naotake, Sada Ken-Ei, Nakatochi Masahiro, Yokoe Yuki, Suzuki Atsuo, Maruyama Shoichi, Murohara Toyoaki, Matsushita Tadashi, Amano Koichi, Atsumi Tatsuya, Takasaki Yoshinari, Ito Satoshi, Hasegawa Hitoshi, Dobashi Hiroaki, Ito Takafumi, Makino Hirofumi, Matsuo Seiichi

    ANNALS OF CLINICAL BIOCHEMISTRY   Vol. 58 ( 2 ) page: 86 - 94   2021.3

  215. Refractory Hypotension Caused by Selenium Deficiency in a Patient on Peritoneal Dialysis.

    Ryuge A, Kim H, Suzuki Y, Okazaki M, Kojima H, Saito S, Kato N, Ishimoto T, Kosugi T, Maruyama S, Mizuno M

    Internal medicine (Tokyo, Japan)     2021.2

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    <p>Selenium is essential for human health; its deficiency leads to cardiac dysfunction. We herein report a 79-year-old man on peritoneal dialysis who presented with refractory hypotension caused by selenium deficiency. He was admitted to our hospital with bacterial pneumonia and hypotension and abnormal electrocardiogram (ECG) findings. Despite improvement of pneumonia, his hypotension continued, and intravenous noradrenalin could not be discontinued. His serum selenium level was extremely low, and he was started on intravenous selenium. His hypotension and ECG findings gradually improved, and noradrenalin was discontinued. Physicians should consider selenium deficiency when patients on PD show refractory hypotension. </p>

    DOI: 10.2169/internalmedicine.6632-20

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  216. Initial responsiveness to darbepoetin alfa and its contributing factors in non-dialysis chronic kidney disease patients in Japan

    Hayashi Terumasa, Kato Hideki, Tanabe Kenichiro, Nangaku Masaomi, Hirakata Hideki, Wada Takashi, Sato Hiroshi, Yamazaki Yasushi, Masaki Takao, Kagimura Tatsuo, Yamamoto Hiroyasu, Hase Hiroki, Kamouchi Masahiro, Imai Enyu, Mizuno Kyoichi, Iwasaki Manabu, Akizawa Tadao, Tsubakihara Yoshiharu, Maruyama Shoichi, Narita Ichiei

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 25 ( 2 ) page: 110 - 119   2021.2

  217. Glucocorticoid treatment is associated with ICU-acquired hypernatremia: a nested case-control study

    Imaizumi Takahiro, Nakatochi Masahiro, Fujita Yoshiro, Yamamoto Rie, Watanabe Kennshi, Maekawa Michitaka, Yamawaka Taishi, Katsuno Takayuki, Maruyama Shoichi

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 25 ( 2 ) page: 131 - 139   2021.2

  218. Clinical manifestations of focal segmental glomerulosclerosis in Japan from the Japan Renal Biopsy Registry: age stratification and comparison with minimal change disease

    Ozeki Takaya, Maruyama Shoichi, Imasawa Toshiyuki, Kawaguchi Takehiko, Kitamura Hiroshi, Kadomura Moritoshi, Katafuchi Ritsuko, Oka Kazumasa, Yokoyama Hitoshi, Sugiyama Hitoshi, Sato Hiroshi

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 2602   2021.1

  219. Cardiovascular disease history and beta-blocker prescription patterns among Japanese and American patients with CKD: a cross-sectional study of the CRIC and CKD-JAC studies

    Imaizumi Takahiro, Hamano Takayuki, Fujii Naohiko, Huang Jing, Xie Dawei, Ricardo Ana C., He Jiang, Soliman Elsayed Z., Kusek John W., Nessel Lisa, Yang Wei, Maruyama Shoichi, Fukagawa Masafumi, Feldman Harold I.

    HYPERTENSION RESEARCH     2021.1

  220. The ISN/RPS 2016 classification predicts renal prognosis in patients with first-onset class III/IV lupus nephritis

    Hachiya Asaka, Karasawa Munetoshi, Imaizumi Takahiro, Kato Noritoshi, Katsuno Takayuki, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Maruyama Shoichi

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 1525   2021.1

  221. Nephrotic syndrome with focal segmental glomerular lesions unclassified by Columbia classification; Pathology and clinical implication

    Ozeki Takaya, Nagata Michio, Katsuno Takayuki, Inagaki Koji, Goto Kazunori, Kato Sawako, Yasuda Yoshinari, Tsuboi Naotake, Maruyama Shoichi

    PLOS ONE   Vol. 16 ( 1 ) page: e0244677   2021.1

  222. Impact of the number of steroid pulses in tonsillectomy combined with steroid pulse therapy: a nationwide retrospective study in Japan

    Moriyama Takahito, Kataoka Hiroshi, Nitta Kosaku, Hirano Keita, Matsuzaki Keiichi, Yasuda Takashi, Yasuda Yoshinari, Koike Kentaro, Maruyama Shoichi, Yokoo Takashi, Matsuo Seiichi, Kawamura Tetsuya, Suzuki Yusuke

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 25 ( 1 ) page: 19 - 27   2021.1

  223. Effects of LDL apheresis on proteinuria in patients with diabetes mellitus, severe proteinuria, and dyslipidemia

    Wada Takashi, Hara Akinori, Muso Eri, Maruyama Shoichi, Kato Sawako, Furuichi Kengo, Yoshimura Kenichi, Toyama Tadashi, Sakai Norihiko, Suzuki Hiroyuki, Tsukamoto Tatsuo, Miyazaki Mariko, Sato Eiichi, Abe Masanori, Shibagaki Yugo, Narita Ichiei, Goto Shin, Sakamaki Yuichi, Yokoyama Hitoshi, Mori Noriko, Yuzawa Yukio, Hasegawa Midori, Matsubara Takeshi, Wada Jun, Tanabe Katsuyuki, Masutani Kosuke, Abe Yasuhiro, Tsuruya Kazuhiko, Fujimoto Shouichi, Iwatsubo Shuji, Tsuda Akihiro, Suzuki Hitoshi, Kasuno Kenji, Terada Yoshio, Nakata Takeshi, Iino Noriaki, Sofue Tadashi, Miyata Hitomi, Nakano Toshiaki, Ohtake Takayasu, Kobayashi Shuzo

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 25 ( 1 ) page: 1 - 8   2021.1

  224. Oral Antibiotics are Effective for Preventing Colonoscopy-associated Peritonitis as a Preemptive Therapy in Patients on Peritoneal Dialysis

    Suzuki Yasuhiro, Mizuno Masashi, Kojima Hiroshi, Sato Yuka, Kim Hangsoo, Kinashi Hiroshi, Katsuno Takayuki, Ishimoto Takuji, Maruyama Shoichi, Ito Yasuhiko

    INTERNAL MEDICINE   Vol. 60 ( 3 ) page: 353 - 356   2021

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    <p><b>Objective </b>In patients on peritoneal dialysis (PD), it was reported that colonoscopy, but not upper gastrointestinal endoscopy, could cause peritonitis as a complication. A guideline of the International Society for Peritoneal Dialysis recommends preemptive intravenous antibiotics administration of ampicillin and aminoglycoside with or without metronidazole, to prevent colonoscopy-associated peritonitis. In this study, we retrospectively evaluated the effects of preemptive antibiotics therapy by oral administration instead of intravenous administration. </p><p><b>Methods </b>We investigated the incidence of colonoscopy-associated peritonitis in a single center. In 170 patients undergoing PD between January 2010 and December 2019, 50 colonoscopies were performed, including 49 with oral administration of amoxicillin and ciprofloxacin and/or metronidazole as preemptive therapy 1 hour before the colonoscopy procedure, and 1 without. </p><p><b>Results </b>We observed no incidence of colonoscopy-associated peritonitis. </p><p><b>Conclusion </b>Generally, oral administration of preemptive antibiotics is less painful and more convenient than intravenous administration, especially in outpatient procedures, such as a colonoscopy. Our results suggest that oral antibiotic administration might be effective for preventing colonoscopy-associated peritonitis in PD patients. </p>

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  225. Acquired Fanconi Syndrome in a Patient with Nontyphoidal Salmonella Bacteremia

    Ryuge Akihiro, Saito Shoji, Morioka Hiroshi, Hachiya Asaka, Kato Noritoshi, Ishimoto Takuji, Kosugi Tomoki, Maruyama Shoichi

    INTERNAL MEDICINE   Vol. 60 ( 5 ) page: 761 - 764   2021

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    <p>Nontyphoidal <i>Salmonella</i> is a common cause of bacterial gastroenteritis, occasionally causing bacteremia. We herein report the case of an 80-year-old man who presented with bacteremia and pre-renal acute kidney injury (AKI) secondary to diarrhea caused by nontyphoidal <i>Salmonella</i>. Despite AKI improvement on fluid administration, some serological abnormalities, such as hypokalemia, hypophosphatemia, and hypouricemia, and abnormal urinary findings emerged, including renal glycosuria and aminoaciduria. Fractional excretion of phosphate and uric acid was increased, suggesting that the serological and urinary abnormalities may have arisen from Fanconi syndrome. Physicians should consider acquired Fanconi syndrome when patients with nontyphoidal <i>Salmonella</i> bacteremia present with electrolyte disorders. </p>

    DOI: 10.2169/internalmedicine.5932-20

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  226. Validity of "One-size-fits-all" Approaches for the National Health Screening and Education Program: A Large-Scale Cohort Study of Corporate Insurance Beneficiaries.

    Kikuchi K, Imaizumi T, Ando M, Kato S, Kondo T, Honda H, Yoshida Y, Maruyama S

    Internal medicine (Tokyo, Japan)     2020.12

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    <p><b>Objective </b>Metabolic syndrome represents a unified condition of atherosclerotic diseases caused by abdominal obesity. The aims of this study were to examine the applicability of the prevalent fixed cut-off values of the abdominal circumference (AC) and body mass index (BMI) to age and gender groups and to identify suitable lifestyle modification factors. </p><p><b>Methods </b>We defined an outcome as having ≥ 2 risk components that are necessary to diagnose metabolic syndrome and examined the cross-sectional association of the AC and BMI with the outcome. We also assessed the effects of time-updated lifestyle information on metabolic traits using longitudinal data. </p><p><b>Patients or Materials </b> We enrolled 2,2953 beneficiaries of a corporate health insurance scheme who underwent annual health examinations between January 2004 and December 2014. </p><p><b>Results </b>The AC (per 5-cm increase, odds ratio [OR] 1.17, 95% confidence interval [CI] 1.12-1.24) and BMI (OR 1.10, 95% CI 1.07-1.14) were significantly associated with the outcome, adjusted for age, gender, current smoking status, drinking habits, and other lifestyle information. The association between the outcome and AC was modified by gender (P for interaction = 0.033), and the association between the outcome and BMI was modified by age group (P for interaction = 0.049). In the longitudinal analysis, current smoking, drinking habits, and unhealthy eating habits were associated with an increased AC and BMI, whereas regular physical activity was associated with a decreased AC and BMI. </p><p><b>Conclusion </b>We showed that the association between the AC or BMI and metabolic syndrome was modified by gender or age group. Further studies will be needed to customize the national health screening and education programs. </p>

    DOI: 10.2169/internalmedicine.5515-20

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  227. A Prospective, Randomized Clinical Trial of Etelcalcetide in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism (the DUET Trial)

    Itano Yuya, Kato Sawako, Tsuboi Masato, Kasuga Hirotake, Tsuruta Yoshinari, Sato Fumihiko, Hishida Manabu, Ishimoto Takuji, Kosugi Tomoki, Ando Masahiko, Kuwatsuka Yachiyo, Maruyama Shoichi

    KIDNEY INTERNATIONAL REPORTS   Vol. 5 ( 12 ) page: 2168 - 2177   2020.12

  228. High urinary glucose is associated with improved renal prognosis in patients with diabetes mellitus

    Itano Yuya, Sobajima Hiroshi, Ohashi Norimi, Shibata Taiga, Fujiya Atsushi, Nagata Takanobu, Ando Masahiko, Imaizumi Takahiro, Kubo Yoko, Ozeki Takaya, Katsuno Takayuki, Kato Sawako, Yasuda Yoshinari, Maruyama Shoichi

    JOURNAL OF DIABETES INVESTIGATION     2020.11

  229. Long-term changes in renal function after treatment initiation and the importance of early diagnosis in maintaining renal function among IgG4-related tubulointerstitial nephritis patients in Japan

    Arai Haruna, Ogata Soshiro, Ozeki Takaya, Takahashi Kazuo, Tsuboi Naotake, Maruyama Shoichi, Inaguma Daijo, Hasegawa Midori, Yuzawa Yukio, Hayashi Hiroki

    ARTHRITIS RESEARCH & THERAPY   Vol. 22 ( 1 ) page: 261   2020.11

  230. C-type lectin Mincle mediates cell death-triggered inflammation in acute kidney injury.

    Tanaka M, Saka-Tanaka M, Ochi K, Fujieda K, Sugiura Y, Miyamoto T, Kohda H, Ito A, Miyazawa T, Matsumoto A, Aoe S, Miyamoto Y, Tsuboi N, Maruyama S, Suematsu M, Yamasaki S, Ogawa Y, Suganami T

    The Journal of experimental medicine   Vol. 217 ( 11 )   2020.11

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    DOI: 10.1084/jem.20192230

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  231. The revised version 2018 of the nationwide web-based registry system for kidney diseases in Japan: Japan Renal Biopsy Registry and Japan Kidney Disease Registry.

    Ozeki T, Maruyama S, Nagata M, Shimizu A, Sugiyama H, Sato H, Yokoyama H, Committee for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology.

    Clinical and experimental nephrology   Vol. 24 ( 11 ) page: 1058 - 1068   2020.11

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    DOI: 10.1007/s10157-020-01932-6

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  232. Prognostic Impact of Parameters of Metabolic Acidosis in Critically Ill Children with Acute Kidney Injury: A Retrospective Observational Analysis Using the PIC Database

    Morooka Hikaru, Kasugai Daisuke, Tanaka Akihito, Ozaki Masayuki, Numaguchi Atsushi, Maruyama Shoichi

    DIAGNOSTICS   Vol. 10 ( 11 )   2020.11

  233. Prevalences of hyperuricemia and electrolyte abnormalities in patients with chronic kidney disease in Japan: A nationwide, cross-sectional cohort study using data from the Japan Chronic Kidney Disease Database (J-CKD-DB)

    Sofue Tadashi, Nakagawa Naoki, Kanda Eiichiro, Nagasu Hajime, Matsushita Kunihiro, Nangaku Masaomi, Maruyama Shoichi, Wada Takashi, Terada Yoshio, Yamagata Kunihiro, Narita Ichiei, Yanagita Motoko, Sugiyama Hitoshi, Shigematsu Takashi, Ito Takafumi, Tamura Kouichi, Isaka Yoshitaka, Okada Hirokazu, Tsuruya Kazuhiko, Yokoyama Hitoshi, Nakashima Naoki, Kataoka Hiromi, Ohe Kazuhiko, Okada Mihoko, Kashihara Naoki

    PLOS ONE   Vol. 15 ( 10 ) page: e0240402   2020.10

  234. Better remission rates in elderly Japanese patients with primary membranous nephropathy in nationwide real-world practice: The Japan Nephrotic Syndrome Cohort Study (JNSCS).

    Yokoyama H, Yamamoto R, Imai E, Maruyama S, Sugiyama H, Nitta K, Tsukamoto T, Uchida S, Takeda A, Sato T, Wada T, Hayashi H, Akai Y, Fukunaga M, Tsuruya K, Masutani K, Konta T, Shoji T, Hiramatsu T, Goto S, Tamai H, Nishio S, Shirasaki A, Nagai K, Yamagata K, Hasegawa H, Yasuda H, Ichida S, Naruse T, Fukami K, Nishino T, Sobajima H, Tanaka S, Akahori T, Ito T, Terada Y, Katafuchi R, Fujimoto S, Okada H, Ishimura E, Kazama JJ, Hiromura K, Mimura T, Suzuki S, Saka Y, Sofue T, Suzuki Y, Shibagaki Y, Kitagawa K, Morozumi K, Fujita Y, Mizutani M, Shigematsu T, Furuichi K, Fujimoto K, Kashihara N, Sato H, Matsuo S, Narita I, Isaka Y

    Clinical and experimental nephrology   Vol. 24 ( 10 ) page: 893 - 909   2020.10

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  235. Temporal change in life and renal prognosis of rapidly progressive glomerulonephritis in Japan via nationwide questionnaire survey (vol 23, pg 573, 2019)

    Yamagata Kunihiro, Usui Joichi, Sugiyama Hitoshi, Maruyama Shoichi, Narita Ichiei

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 24 ( 10 ) page: 976 - 977   2020.10

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    DOI: 10.1007/s10157-020-01901-z

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  236. THE ROLE OF FRUCTOSE METABOLISM IN VASCULAR ENDOTHELIAL FUNCTION IN DIABETES

    Ishimoto Takuji, Doke Tomohito, Hayasaki Takahiro, Kato Noritoshi, Maruyama Shoichi

    NEPHROLOGY   Vol. 25   page: 62 - 62   2020.10

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  237. URINARY CD11B AND CD163 REFLECT GLOMERULAR LEUKOCYTE ACCUMULATIONS IN ANCA-ASSOCIATED GLOMERULONEPHRITIS

    Tsuboi Naotake, Yokoe Yuki, Kitagawa Akimitsu, Karasawa Munetoshi, Imaizumi Takahiro, Ozeki Takaya, Takayuki Katsuno, Maruyama Shoichi

    NEPHROLOGY   Vol. 25   page: 35 - 36   2020.10

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  238. EXOSOMES FROM CKD PATIENTS HAVE ATHEROSCLEROGENIC PROPERTIES

    Kato Noritoshi, Nishio Fumitoshi, Ishimoto Takuji, Kosugi Tomoki, Maruyama Shoichi

    NEPHROLOGY   Vol. 25   page: 62 - 62   2020.10

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  239. ESTABLISHMENT OF A COMPREHENSIVE NATIONWIDE BIOBANK FOR KIDNEY DISEASES WITH DEEP GENETIC DATA, DETAILED CLINICAL INFORMATION AND BIOSPECIMENS

    Hirakawa Yosuke, Nagasu Hajime, Sugawara Yuka, Koshiba Seizo, Narita Ichiei, Wada Takashi, Yanagita Motoko, Wada Jun, Maruyama Shoichi, Nakano Toshiaki, Yamamoto Masayuki, Nangaku Masaomi, Kashihara Naoki

    NEPHROLOGY   Vol. 25   page: 70 - 70   2020.10

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  240. CLINICAL UTILITY OF REMISSION CRITERIA BY JAPANESE SOCIETY OF NEPHROLOGY IN IGA NEPHROPATHY

    Yasuda Yoshinari, Kaihan Ahmad Baseer, Maruyama Shoichi

    NEPHROLOGY   Vol. 25   page: 15 - 15   2020.10

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  241. CLINICAL UTILITY OF SERUM INDOXYL SULPHATE MEASURED BY NEW ENZYMATIC METHOD AMONG PATIENTS WITH CKD

    Yasuda Yoshinari, Kaihan Ahamad Baseer, Kikuchi Ryosuke, Maruyama Shoichi

    NEPHROLOGY   Vol. 25   page: 73 - 73   2020.10

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  242. CIRCULATING ANTI-THSD7A ANTIBODY IN JAPANESE PATIENTS WITH PRIMARY MEMBRANOUS NEPHROPATHY

    Akiyama Shin'ichi, Maruyama Shoichi

    NEPHROLOGY   Vol. 25   page: 36 - 36   2020.10

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  243. CASES OF ACUTE APPENDICITIS IN PATIENTS ON PERITONEAL DIALYSIS (PD) IN A SINGLE CENTRE DURING 15 YEARS

    Mizuno Masashi, Suzuki Yasuhiro, Kojima Hiroshi, Sato Yuka, Kinashi Hiroshi, Katsuno Takayuki, Maruyama Shoichi, Ito Yasuhiko

    NEPHROLOGY   Vol. 25   page: 82 - 82   2020.10

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  244. ANALYSIS OF FREQUENCY AND KINDS OF ALARM HISTORIES OF HOME PD SYSTEM KAGUYA DURING THE INTRODUCTION: PERIOD IN A SINGLE CENTRE

    Hiramatsu Tetsuaki, Mizuno Masasi, Suzuki Yasuhiro, Nomori Sumiyo, Suzuki Masafumi, Shiga Yoshiko, Sato Yuka, Nakamura Tomohiro, Ishimoto Takuji, Kosugi Tomoki, Maruyama Shoichi, Koyama Tomio

    NEPHROLOGY   Vol. 25   page: 77 - 78   2020.10

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  245. The status of the tumor microenvironment changes dynamics of the balance of CD8(+) T cells and Treg cells in renal cell carcinoma

    Sugiyama Daisuke, Muramatsu Tomoaki, Kobayashi Yoichi, Sassa Naoto, Maruyama Shoichi, Goto Momokazu, Akatsuka Yoshiki, Nishikawa Hiroyoshi

    CANCER RESEARCH   Vol. 80 ( 16 )   2020.8

  246. Comprehensive Dipeptide Profiling and Quantitation by Capillary Electrophoresis and Liquid Chromatography Coupled with Tandem Mass Spectrometry

    Ozawa Hitoshi, Hirayama Akiyoshi, Ishikawa Takamasa, Kudo Ryuhei, Maruyama Midori, Shoji Futaba, Doke Tomohito, Ishimoto Takuji, Maruyama Shoichi, Soga Tomoyoshi, Tomita Masaru

    ANALYTICAL CHEMISTRY   Vol. 92 ( 14 ) page: 9799 - 9806   2020.7

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    DOI: 10.1021/acs.analchem.0c01258

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  247. Prevalence of anemia in patients with chronic kidney disease in Japan: A nationwide, cross-sectional cohort study using data from the Japan Chronic Kidney Disease Database (J-CKD-DB).

    Sofue T, Nakagawa N, Kanda E, Nagasu H, Matsushita K, Nangaku M, Maruyama S, Wada T, Terada Y, Yamagata K, Narita I, Yanagita M, Sugiyama H, Shigematsu T, Ito T, Tamura K, Isaka Y, Okada H, Tsuruya K, Yokoyama H, Nakashima N, Kataoka H, Ohe K, Okada M, Kashihara N

    PloS one   Vol. 15 ( 7 ) page: e0236132   2020.7

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    DOI: 10.1371/journal.pone.0236132

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  248. Impact of old age on the association between in-center extended-hours hemodialysis and mortality in patients on incident hemodialysis

    Okazaki Masaki, Inaguma Daijo, Imaizumi Takahiro, Hishida Manabu, Kurasawa Shimon, Kubo Yoko, Kato Sawako, Yasuda Yoshinari, Katsuno Takayuki, Kaneda Fumika, Maruyama Shoichi

    PLOS ONE   Vol. 15 ( 7 ) page: e0235900   2020.7

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    DOI: 10.1371/journal.pone.0235900

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  249. Clinical impact of urinary CD11b and CD163 on the renal outcomes of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.

    Yokoe Y, Tsuboi N, Imaizumi T, Kitagawa A, Karasawa M, Ozeki T, Endo N, Sawa Y, Kato S, Katsuno T, Maruyama S, Yamagata K, Usui J, Nagata M, Sada KE, Sugiyama H, Amano K, Arimura Y, Atsumi T, Yuzawa Y, Dobashi H, Takasaki Y, Harigai M, Hasegawa H, Makino H, Matsuo S

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     2020.7

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    DOI: 10.1093/ndt/gfaa097

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  250. Complement profile in microscopic polyangiitis and granulomatosis with polyangiitis: analysis using sera from a nationwide prospective cohort study

    Fukui S., Ichinose K., Sada K-E, Miyamoto J., Harigai M., Amano K., Atsumi T., Takasaki Y., Dobashi H., Arimura Y., Hasegawa H., Yuzawa Y., Yamagata K., Tsuboi N., Maruyama S., Matsuo S., Makino H., Maeda T., Kawakami A.

    SCANDINAVIAN JOURNAL OF RHEUMATOLOGY   Vol. 49 ( 4 ) page: 301 - 311   2020.7

  251. Incidence of remission and relapse of proteinuria, end-stage kidney disease, mortality, and major outcomes in primary nephrotic syndrome: the Japan Nephrotic Syndrome Cohort Study (JNSCS).

    Yamamoto R, Imai E, Maruyama S, Yokoyama H, Sugiyama H, Nitta K, Tsukamoto T, Uchida S, Takeda A, Sato T, Wada T, Hayashi H, Akai Y, Fukunaga M, Tsuruya K, Masutani K, Konta T, Shoji T, Hiramatsu T, Goto S, Tamai H, Nishio S, Shirasaki A, Nagai K, Yamagata K, Hasegawa H, Yasuda H, Ichida S, Naruse T, Nishino T, Sobajima H, Tanaka S, Akahori T, Ito T, Terada Y, Katafuchi R, Fujimoto S, Okada H, Ishimura E, Kazama JJ, Hiromura K, Mimura T, Suzuki S, Saka Y, Sofue T, Suzuki Y, Shibagaki Y, Kitagawa K, Morozumi K, Fujita Y, Mizutani M, Shigematsu T, Kashihara N, Sato H, Matsuo S, Narita I, Isaka Y

    Clinical and experimental nephrology   Vol. 24 ( 6 ) page: 526 - 540   2020.6

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    DOI: 10.1007/s10157-020-01864-1

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  252. THE ANNUAL VARIATION OF CRA/ALBUMIN RATIO IS AN ACCURATE PROGNOSTIC FACTOR IN DIALYSIS PATIENTS

    Yasuda Kaoru, Takahashi Hiroshi, Morozumi Kunio, Maruyama Shoichi

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 35   page: 1887 - 1887   2020.6

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  253. Darbepoetin Alfa in Patients with Advanced CKD without Diabetes: Randomized, Controlled Trial.

    Hayashi T, Maruyama S, Nangaku M, Narita I, Hirakata H, Tanabe K, Morita S, Tsubakihara Y, Imai E, Akizawa T, PREDICT Investigators.

    Clinical journal of the American Society of Nephrology : CJASN   Vol. 15 ( 5 ) page: 608 - 615   2020.5

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    DOI: 10.2215/CJN.08900719

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  254. A nationwide survey on clinical practice patterns and bleeding complications of percutaneous native kidney biopsy in Japan.

    Kawaguchi T, Nagasawsa T, Tsuruya K, Miura K, Katsuno T, Morikawa T, Ishikawa E, Ogura M, Matsumura H, Kurayama R, Matsumoto S, Marui Y, Hara S, Maruyama S, Narita I, Okada H, Ubara Y, Committee of Practical Guide for Kidney Biopsy 2019.

    Clinical and experimental nephrology   Vol. 24 ( 5 ) page: 389 - 401   2020.5

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    DOI: 10.1007/s10157-020-01869-w

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  255. Correction to: A nationwide survey on clinical practice patterns and bleeding complications of percutaneous native kidney biopsy in Japan.

    Kawaguchi T, Nagasawsa T, Tsuruya K, Miura K, Katsuno T, Morikawa T, Ishikawa E, Ogura M, Matsumura H, Kurayama R, Matsumoto S, Marui Y, Hara S, Maruyama S, Narita I, Okada H, Ubara Y, Committee of Practical Guide for Kidney Biopsy 2019.

    Clinical and experimental nephrology   Vol. 24 ( 5 ) page: 402 - 403   2020.5

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    DOI: 10.1007/s10157-020-01883-y

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  256. J-CKD-DB: a nationwide multicentre electronic health record-based chronic kidney disease database in Japan.

    Nakagawa N, Sofue T, Kanda E, Nagasu H, Matsushita K, Nangaku M, Maruyama S, Wada T, Terada Y, Yamagata K, Narita I, Yanagita M, Sugiyama H, Shigematsu T, Ito T, Tamura K, Isaka Y, Okada H, Tsuruya K, Yokoyama H, Nakashima N, Kataoka H, Ohe K, Okada M, Kashihara N

    Scientific reports   Vol. 10 ( 1 ) page: 7351   2020.4

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    DOI: 10.1038/s41598-020-64123-z

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  257. Inter-leg systolic blood pressure difference predicts cardiovascular events and mortality in incident hemodialysis patients

    Kato Sawako, Lindholm Bengt, Qureshi Abdul Rashid, Mukai Hideyuki, Yuzawa Yukio, Maruyama Shoichi

    INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS   Vol. 43 ( 4 ) page: 217 - 224   2020.4

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    DOI: 10.1177/0391398819882703

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  258. Survival Benefit of Maintained or Increased Body Mass Index in Patients Undergoing Extended-Hours Hemodialysis Without Dietary Restrictions

    Hishida Manabu, Imaizumi Takahiro, Nishiyama Toshiro, Okazaki Masaki, Kaihan Ahmad Baseer, Kato Sawako, Kubo Yoko, Ando Masahiko, Kaneda Hiroshi, Maruyama Shoichi

    JOURNAL OF RENAL NUTRITION   Vol. 30 ( 2 ) page: 154 - 162   2020.3

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    DOI: 10.1053/j.jrn.2019.06.002

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  259. Pharmacological monitoring of antiepileptic drugs in epilepsy patients on haemodialysis

    Araki Kunihiko, Nakamura Tomohiko, Takeuchi Yuko, Morozumi Saori, Horie Katsunori, Kobayashi Yasushi, Kawakami Osamu, Sobue Fumio, Ueda Takuya, Hamada Kensuke, Ando Tetsuo, Inoue Yushi, Yasui Keizo, Morozumi Kunio, Maruyama Shoichi, Katsuno Masahisa

    EPILEPTIC DISORDERS   Vol. 22 ( 1 ) page: 90 - 102   2020.2

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    DOI: 10.1684/epd.2020.1139

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  260. Ectopic Relapse of Anti-neutrophil Cytoplasmic Antibody-associated Pituitary Vasculitis with No Elevation of Anti-neutrophil Cytoplasmic Antibodies after Renal Remission.

    Muto R, Inagaki K, Sato N, Sameshima T, Nagakura Y, Baba S, Kato N, Maruyama S, Akahori T

    Internal medicine (Tokyo, Japan)   Vol. 59 ( 24 ) page: 3187 - 3193   2020

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    DOI: 10.2169/internalmedicine.4731-20

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  261. Effectiveness of Lifestyle Intervention Using the Internet of Things System for Individuals with Early Type 2 Diabetes Mellitus

    Kato Sawako, Ando Masahiko, Honda Hiroyuki, Yoshida Yasuko, Imaizumi Takahiro, Yamamoto Naoki, Maruyama Shoichi

    INTERNAL MEDICINE   Vol. 59 ( 1 ) page: 45 - 53   2020

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    DOI: 10.2169/internalmedicine.3150-19

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  262. Successful Introduction of Peritoneal Dialysis in an End-stage Renal Failure Patient with Idiopathic Aplastic Anemia

    Suzuki Yasuhiro, Mizuno Masashi, Sakata Fumiko, Kojima Hiroshi, Sato Yuka, Kishimoto Mayuko, Suzuki Nobuaki, Kinashi Hiroshi, Saito Shoji, Katsuno Takayuki, Kosugi Tomoki, Maruyama Shoichi, Murata Makoto, Kiyoi Hitoshi, Ito Yasuhiko

    INTERNAL MEDICINE   Vol. 59 ( 5 ) page: 683 - 687   2020

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    DOI: 10.2169/internalmedicine.3775-19

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  263. Peripheral artery disease at the time of dialysis initiation and mortality: a prospective observational multicenter study

    Morooka Hikaru, Tanaka Akihito, Inaguma Daijo, Maruyama Shoichi

    BMJ OPEN   Vol. 10 ( 12 ) page: e042315   2020

  264. aHUS; pathology and clinical aspects

    Kato Noritoshi, Tatematsu Yoshitaka, Maruyama Shoichi

    Japanese Journal of Thrombosis and Hemostasis   Vol. 31 ( 1 ) page: 45 - 54   2020

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    DOI: 10.2491/jjsth.31.45

  265. Elemental Consideration of Carbonization Phenomena in Inverter Fed Motor

    Yoshitake Yuichiro, Kojima Hiroaki, Kasai Yuki, Maruyama Shoichi, Kojima Hiroki, Hayakawa Naoki

    IEEJ Transactions on Fundamentals and Materials   Vol. 140 ( 1 ) page: 40 - 47   2020

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    <p>"Carbonization" were detected as the precursor phenomena on the insulation burning of rotating machine, and we have studied the generation condition for higher <i>dV/dt</i> of the inverter surge. We built the experimental setup of elemental model, which could simulate the steeper surge from SiC device inverter and construct the stator insulation system inside the motor core to control the insulation sheets configuration. By revealing the quantitative conditions of the carbonization generation, we verified that the voltage to suppress the carbonization generation depended on the location of the mold release layer. Therefore, we developed the guideline of insulation design to prevent the carbonization for the steeper inverter surge.</p>

    DOI: 10.1541/ieejfms.140.40

  266. aHUS; pathology and clinical aspects

    Kato Noritoshi, Tatematsu Yoshitaka, Maruyama Shoichi

    Japanese Journal of Thrombosis and Hemostasis   Vol. 31 ( 1 ) page: 45 - 54   2020

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    DOI: 10.2491/jjsth.31.45

  267. Elemental Consideration of Carbonization Phenomena in Inverter Fed Motor

    Yoshitake Yuichiro, Kojima Hiroaki, Kasai Yuki, Maruyama Shoichi, Kojima Hiroki, Hayakawa Naoki

    IEEJ Transactions on Fundamentals and Materials   Vol. 140 ( 1 ) page: 40 - 47   2020

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    Publisher:The Institute of Electrical Engineers of Japan  

    <p>"Carbonization" were detected as the precursor phenomena on the insulation burning of rotating machine, and we have studied the generation condition for higher <i>dV/dt</i> of the inverter surge. We built the experimental setup of elemental model, which could simulate the steeper surge from SiC device inverter and construct the stator insulation system inside the motor core to control the insulation sheets configuration. By revealing the quantitative conditions of the carbonization generation, we verified that the voltage to suppress the carbonization generation depended on the location of the mold release layer. Therefore, we developed the guideline of insulation design to prevent the carbonization for the steeper inverter surge.</p>

    DOI: 10.1541/ieejfms.140.40

  268. Lower levels of proteinuria are associated with elevated mortality in incident dialysis patients

    Hishida Manabu, Shafi Tariq, Appel Lawrence J., Maruyama Shoichi, Inaguma Daijo, Matsushita Kunihiro

    PLOS ONE   Vol. 14 ( 12 ) page: e0226866   2019.12

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    DOI: 10.1371/journal.pone.0226866

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  269. Excessive salt intake increases peritoneal solute transport rate via local tonicity-responsive enhancer binding protein in subtotal nephrectomized mice

    Sun Ting, Sakata Fumiko, Ishii Takako, Tawada Mitsuhiro, Suzuki Yasuhiro, Kinashi Hiroshi, Katsuno Takayuki, Takei Yoshifumi, Maruyama Shoichi, Mizuno Masashi, Ito Yasuhiko

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 34 ( 12 ) page: 2031 - 2042   2019.12

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    DOI: 10.1093/ndt/gfz045

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  270. Increase of core temperature affected the progression of kidney injury by repeated heat stress exposure

    Sato Yuka, Roncal-Jimenez Carlos A., Andres-Hernando Ana, Jensen Thomas, Tolan Dean R., Sanchez-Lozada Laura G., Newman Lee S., Butler-Dawson Jaime, Sorensen Cecilia, Glaser Jason, Miyazaki Makoto, Diaz Henry F., Ishimoto Takuji, Kosugi Tomoki, Maruyama Shoichi, Garcia Gabriela E., Lanaspa Miguel A., Johnson Richard J.

    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY   Vol. 317 ( 5 ) page: F1111 - F1121   2019.11

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    DOI: 10.1152/ajprenal.00259.2019

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  271. Variations in actual practice patterns and their deviations from the clinical practice guidelines for nephrotic syndrome in Japan: certified nephrologists' questionnaire survey

    Niihata Kakuya, Nishiwaki Hiroki, Kurita Noriaki, Okada Hirokazu, Maruyama Shoichi, Narita Ichiei, Shibagaki Yugo, Nakaya Izaya

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 23 ( 11 ) page: 1288 - 1297   2019.11

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    DOI: 10.1007/s10157-019-01772-z

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  272. Circulating levels of CD34(+) cells predict longterm cardiovascular outcomes in patients on maintenance hemodialysis

    Kaihan Ahmad Baseer, Hishida Manabu, Imaizumi Takahiro, Okazaki Masaki, Kaihan Ahmad Naseer, Katsuno Takayuki, Taguchi Akihiko, Yasuda Yoshinari, Tsuboi Naotake, Kosugi Tomoki, Maruyama Shoichi

    PLOS ONE   Vol. 14 ( 10 ) page: e0223390   2019.10

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    DOI: 10.1371/journal.pone.0223390

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  273. CD55 EXPRESSION CHANGES IN MESOTHELIAL CELLS OF PATIENTS ON PERITONEAL DIALYSIS (PD) THERAPY

    Ozeki Toshikazu, Mizuno Masashi, Kobayashi Kazuma, Iguchi Daiki, Sei Yumi, Suzuki Yasuhiro, Kojima Hiroshi, Fukui Sosuke, Yamashita Ryoko, Kinashi Hiroshi, Imai Masaki, Maruyama Shoichi, Ito Yasuhiko

    MOLECULAR IMMUNOLOGY   Vol. 114   page: 422 - 422   2019.10

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  274. Fructose increases the activity of sodium hydrogen exchanger in renal proximal tubules that is dependent on ketohexokinase

    Hayasaki Takahiro, Ishimoto Takuji, Doke Tomohito, Hirayama Akiyoshi, Soga Tomoyoshi, Furuhashi Kazuhiro, Kato Noritoshi, Kosugi Tomoki, Tsuboi Naotake, Lanaspa Miguel A., Johnson Richard J., Maruyama Shoichi, Kadomatsu Kenji

    JOURNAL OF NUTRITIONAL BIOCHEMISTRY   Vol. 71   page: 54 - 62   2019.9

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    DOI: 10.1016/j.jnutbio.2019.05.017

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  275. Connective tissue growth factor is correlated with peritoneal lymphangiogenesis

    Kinashi Hiroshi, Toda Naohiro, Sun Ting, Nguyen Tri Q., Suzuki Yasuhiro, Katsuno Takayuki, Yokoi Hideki, Aten Jan, Mizuno Masashi, Maruyama Shoichi, Yanagita Motoko, Goldschmeding Roel, Ito Yasuhiko

    SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page: 12175   2019.8

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    DOI: 10.1038/s41598-019-48699-9

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  276. Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction

    Hara Akitoshi, Kobayashi Hiroki, Asai Naoya, Saito Shigeyoshi, Higuchi Takahiro, Kato Katsuhiro, Okumura Takahiro, Bando Yasuko K., Takefuji Mikito, Mizutani Yasuyuki, Miyai Yuki, Saito Shoji, Maruyama Shoichi, Maeda Keiko, Ouchi Noriyuki, Nagasaka Arata, Miyata Takaki, Mii Shinji, Kioka Noriyuki, Worthley Daniel L., Murohara Toyoaki, Takahashi Masahide, Enomoto Atsushi

    CIRCULATION RESEARCH   Vol. 125 ( 4 ) page: 414 - 430   2019.8

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    DOI: 10.1161/CIRCRESAHA.119.314806

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  277. miR-146a targeted to splenic macrophages prevents sepsis-induced multiple organ injury

    Funahashi Yoshio, Kato Noritoshi, Masuda Tomohiro, Nishio Fumitoshi, Kitai Hiroki, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Matsuda Naoyuki, Maruyama Shoichi, Kadomatsu Kenji

    LABORATORY INVESTIGATION   Vol. 99 ( 8 ) page: 1130 - 1142   2019.8

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    DOI: 10.1038/s41374-019-0190-4

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  278. The effect of maintaining high hemoglobin levels on long-term kidney function in kidney transplant recipients: a randomized controlled trial

    Tsujita Makoto, Kosugi Tomoki, Goto Norihiko, Futamura Kenta, Nishihira Morikuni, Okada Manabu, Hiramitsu Takahisa, Narumi Shunji, Uchida Kazuharu, Takeda Asami, Morozumi Kunio, Maruyama Shoichi, Watarai Yoshihiko

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 34 ( 8 ) page: 1409 - 1416   2019.8

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    DOI: 10.1093/ndt/gfy365

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  279. CD147/Basigin Deficiency Prevents the Development of Podocyte Injury through FAK Signaling

    Yoshioka Tomoki, Kosugi Tomoki, Masuda Tomohiro, Watanabe Tomoharu, Ryuge Akihiro, Nagaya Hiroshi, Maeda Kayaho, Sato Yuka, Katsuno Takayuki, Kato Noritoshi, Ishimoto Takuji, Yuzawa Yukio, Maruyama Shoichi, Kadomatsu Kenji

    AMERICAN JOURNAL OF PATHOLOGY   Vol. 189 ( 7 ) page: 1338 - 1350   2019.7

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    DOI: 10.1016/j.ajpath.2019.04.003

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  280. Tumor-infiltrating lymphocytes in renal cancer patients demonstrate a diverse PD-1 expression and characteristic Treg classification

    Sugiyama Daisuke, Muramatsu Tomoaki, Kobayashi Yoichi, Sassa Naoto, Maruyama Shoichi, Goto Momokazu, Akatsuka Yoshiki, Nishikawa Hiroyoshi

    CANCER RESEARCH   Vol. 79 ( 13 )   2019.7

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    DOI: 10.1158/1538-7445.AM2019-4047

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  281. CRP / ALB RATIO AS A STRONG PREDICTOR OF MORTALITY IN DIALYSIS PATIENTS

    Yasuda Kaoru, Takahasho Hiroshi, Yamazaki Chikao, Morozumi Kunio, Maruyama Shoichi

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 34   page: .   2019.6

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  282. NOVEL PATHOPHYSIOLOGIC ROLE OF MIR-146A FOR SPLENIC MACROPHAGE INTERFERENCE IN SEPSIS-RELATED KIDNEY INJURY

    Funahashi Yoshio, Kato Noritoshi, Ishimoto Takuji, Kosugi Tomoki, Maruyama Shoichi

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 34   page: .   2019.6

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  283. THE DURATION FROM RECOGNITION OF SHOCK TO THE INDUCTION OF THE DIRECT HEMOPERFUSION OF POLYMYXIN B-IMMOBILIZED FIBER CRITICALLY DETERMINES THE SURVIVAL OF PATIENT WITH SEPTIC SHOCK

    Funahashi Yoshio, Oishi Hideto, Maruyama Shoichi

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 34   page: .   2019.6

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  284. Association Between Tonsillectomy and Outcomes in Patients With Immunoglobulin A Nephropathy

    Hirano Keita, Matsuzaki Keiichi, Yasuda Takashi, Nishikawa Masako, Yasuda Yoshinari, Koike Kentaro, Maruyama Shoichi, Yokoo Takashi, Matsuo Seiichi, Kawamura Tetsuya, Suzuki Yusuke

    JAMA NETWORK OPEN   Vol. 2 ( 5 ) page: e194772   2019.5

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    DOI: 10.1001/jamanetworkopen.2019.4772

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  285. Effects of long-term treatment with low-GDP, pH-neutral solutions on peritoneal membranes in peritoneal dialysis patients

    Tawada Mitsuhiro, Hamada Chieko, Suzuki Yasuhiro, Sakata Fumiko, Sun Ting, Kinashi Hiroshi, Katsuno Takayuki, Takei Yoshifumi, Maruyama Shoichi, Honda Kazuho, Mizuno Masashi, Ito Yasuhiko

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 23 ( 5 ) page: 689 - 699   2019.5

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    DOI: 10.1007/s10157-018-1679-7

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  286. Temporal change in life and renal prognosis of rapidly progressive glomerulonephritis in Japan via nationwide questionnaire survey.

    Yamagata K, Usui J, Sugiyama H, Maruyama S, Narita I

    Clinical and experimental nephrology   Vol. 23 ( 4 ) page: 573 - 575   2019.4

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    DOI: 10.1007/s10157-018-1663-2

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  287. A grading system that predicts the risk of dialysis induction in IgA nephropathy patients based on the combination of the clinical and histological severity.

    Okonogi H, Kawamura T, Joh K, Koike K, Miyazaki Y, Ogura M, Tsuboi N, Hirano K, Matsushima M, Yokoo T, Horikoshi S, Suzuki Y, Yasuda T, Shirai S, Shibata T, Hattori M, Akioka Y, Katafuchi R, Hashiguchi A, Hisano S, Shimizu A, Kimura K, Maruyama S, Matsuo S, Tomino Y, Special IgA Nephropathy Study Group.

    Clinical and experimental nephrology   Vol. 23 ( 1 ) page: 16 - 25   2019.1

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    DOI: 10.1007/s10157-018-1657-0

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  288. Increase of Eosinophil in Dialysate During Induction of Peritoneal Dialysis

    Shigemoto Emi, Mizuno Masashi, Suzuki Yasuhiro, Kobayashi Kazuma, Sakata Fumiko, Kariya Tetsuyoshi, Katsuno Takayuki, Maruyama Shoichi, Ito Yasuhiko

    PERITONEAL DIALYSIS INTERNATIONAL   Vol. 39 ( 1 ) page: 90 - +   2019

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    DOI: 10.3747/pdi.2017.00205

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  289. Immunology of membranous nephropathy.

    Akiyama S, Imai E, Maruyama S

    F1000Research   Vol. 8   2019

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    DOI: 10.12688/f1000research.17589.1

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  290. Additional Prognostic Value of Toe-Brachial Index Beyond Ankle-Brachial Index in Hemodialysis Patients

    Hishida Manabu, Imaizumi Takahiro, Okazaki Masaki, Maruyama Shoichi, Matsushita Kunihiro

    CIRCULATION   Vol. 139   2019

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    DOI: 10.1161/circ.139.suppl_1.P307

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  291. Short-Term Steroid Regimen for Adult Steroid-Sensitive Minimal Change Disease

    Ozeki Takaya, Katsuno Takayuki, Hayashi Hiroki, Kato Sawako, Yasuda Yoshinari, Ando Masahiko, Tsuboi Naotake, Hagiwara Daisuke, Arima Hiroshi, Maruyama Shoichi

    AMERICAN JOURNAL OF NEPHROLOGY   Vol. 49 ( 1 ) page: 54 - 63   2019

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    DOI: 10.1159/000495352

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  292. 5. Pathogenesis and Treatment of Nephrotic Syndrome

    Maruyama Shoichi, Akiyama Shin'ichi, Ishimoto Takuji

    Nihon Naika Gakkai Zasshi   Vol. 108 ( 3 ) page: 535 - 539   2019

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    DOI: 10.2169/naika.108.535

  293. 5. Pathogenesis and Treatment of Nephrotic Syndrome

    Maruyama Shoichi, Akiyama Shin'ichi, Ishimoto Takuji

    Nihon Naika Gakkai Zasshi   Vol. 108 ( 3 ) page: 535 - 539   2019

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    Publisher:The Japanese Society of Internal Medicine  

    DOI: 10.2169/naika.108.535

  294. Myonectin Is an Exercise-Induced Myokine That Protects the Heart From Ischemia-Reperfusion Injury

    Otaka Naoya, Shibata Rei, Ohashi Koji, Uemura Yusuke, Kambara Takahiro, Enomoto Takashi, Ogawa Hayato, Ito Masanori, Kawanishi Hiroshi, Maruyama Sonomi, Joki Yusuke, Fujikawa Yusuke, Narita Shingo, Unno Kazumasa, Kawamoto Yoshiyuki, Murate Takashi, Murohara Toyoaki, Ouchi Noriyuki

    CIRCULATION RESEARCH   Vol. 123 ( 12 ) page: 1326 - 1338   2018.12

  295. Regional variations in immunosuppressive therapy in patients with primary nephrotic syndrome: the Japan nephrotic syndrome cohort study.

    Yamamoto R, Imai E, Maruyama S, Yokoyama H, Sugiyama H, Nitta K, Tsukamoto T, Uchida S, Takeda A, Sato T, Wada T, Hayashi H, Akai Y, Fukunaga M, Tsuruya K, Masutani K, Konta T, Shoji T, Hiramatsu T, Goto S, Tamai H, Nishio S, Shirasaki A, Nagai K, Yamagata K, Hasegawa H, Yasuda H, Ichida S, Naruse T, Fukami K, Nishino T, Sobajima H, Tanaka S, Akahori T, Ito T, Yoshio T, Katafuchi R, Fujimoto S, Okada H, Ishimura E, Kazama JJ, Hiromura K, Mimura T, Suzuki S, Saka Y, Sofue T, Suzuki Y, Shibagaki Y, Kitagawa K, Morozumi K, Fujita Y, Mizutani M, Shigematsu T, Kashihara N, Sato H, Matsuo S, Narita I, Isaka Y

    Clinical and experimental nephrology   Vol. 22 ( 6 ) page: 1266 - 1280   2018.12

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    DOI: 10.1007/s10157-018-1579-x

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  296. Serum alpha cKlotho as a Predictor of Graft Dysfunction After Kidney Transplantation

    Tsujita M., Kosugi T., Masuda T., Okada M., Futamura K., Hiramitsu T., Goto N., Shunji N., Watarai Y., Maruyama S.

    TRANSPLANTATION PROCEEDINGS   Vol. 50 ( 10 ) page: 3440-3444   2018.12

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    DOI: 10.1016/j.transproceed.2018.09.008

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  297. A Refractory Case of Secondary Membranous Nephropathy Concurrent with IgG4-related Tubulointerstitial Nephritis.

    Arai H, Toda N, Kamimatsuse R, Nishioka K, Endo S, Akiyama S, Maruyama S, Matsubara T, Yokoi H, Yanagita M

    Internal medicine (Tokyo, Japan)   Vol. 57 ( 19 ) page: 2873-2877   2018.10

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    DOI: 10.2169/internalmedicine.0836-18

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  298. Why are women slimmer than men in developed countries?

    Maruyama Shiko, Nakamura Sayaka

    ECONOMICS & HUMAN BIOLOGY   Vol. 30   page: 1-13   2018.9

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    DOI: 10.1016/j.ehb.2018.04.002

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  299. Glioblastoma Cell Lines Display Different Sensitivities to Plasma-Activated Medium

    Tanaka Hiromasa, Mizuno Masaaki, Ishikawa Kenji, Takeda Keigo, Hashizume Hiroshi, Nakamura Kae, Utsumi Fumi, Kajiyama Hiroaki, Okazaki Yasumasa, Toyokuni Shinya, Akiyama Shinichi, Maruyama Shoichi, Kikkawa Fumitaka, Hori Masaru

    IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES   Vol. 2 ( 2 ) page: 99-102   2018.3

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    DOI: 10.1109/TRPMS.2017.2721973

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  300. A Refractory Case of Secondary Membranous Nephropathy Concurrent with IgG4-related Tubulointerstitial Nephritis

    Arai Hiroyuki, Toda Naohiro, Kamimatsuse Ryo, Nishioka Keisuke, Endo Shuichiro, Akiyama Shinichi, Maruyama Shoichi, Matsubara Takeshi, Yokoi Hideki, Yanagita Motoko

    INTERNAL MEDICINE   Vol. 57 ( 19 ) page: 2873-2877   2018

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    DOI: 10.2169/internalmedicine.0838-18

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  301. ANCA関連血管炎診療ガイドライン2017

    有村 義宏, 針谷 正祥, 丸山 彰一, 本間 栄

    日本内科学会雑誌   Vol. 107 ( 4 ) page: 741 - 745   2018

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    DOI: 10.2169/naika.107.741

  302. Development of a Comprehensive Chronic Kidney Disease Database and Its Expansion and Enhancement of Connectivity

    KASHIHARA NAOKI, OKADA MIHOKO, YOKOYAMA HITOSHI, NANGAKU MASAOMI, YAMAGATA KUNIHIRO, WADA TAKASHI, NAKASHIMA NAOKI, SUGIYAMA HITOSHI, MARUYAMA SHOICHI

    Japan Journal of Medical Informatics   Vol. 38 ( 3 ) page: 150 - 151   2018

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    DOI: 10.14948/jami.38.150

  303. ANCA関連血管炎診療ガイドライン2017

    有村 義宏, 針谷 正祥, 丸山 彰一, 本間 栄

    日本内科学会雑誌   Vol. 107 ( 4 ) page: 741 - 745   2018

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    Publisher:一般社団法人 日本内科学会  

    DOI: 10.2169/naika.107.741

  304. Development of a Comprehensive Chronic Kidney Disease Database and Its Expansion and Enhancement of Connectivity

    KASHIHARA NAOKI, OKADA MIHOKO, YOKOYAMA HITOSHI, NANGAKU MASAOMI, YAMAGATA KUNIHIRO, WADA TAKASHI, NAKASHIMA NAOKI, SUGIYAMA HITOSHI, MARUYAMA SHOICHI

    Japan Journal of Medical Informatics   Vol. 38 ( 3 ) page: 150 - 151   2018

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    DOI: 10.14948/jami.38.150

  305. The association between intensive care unit-acquired hypernatraemia and mortality in critically ill patients with cerebrovascular diseases: a single-centre cohort study in Japan.

    Imaizumi T, Nakatochi M, Fujita Y, Nomura R, Watanabe K, Maekawa M, Yamakawa T, Katsuno T, Maruyama S

    BMJ open   Vol. 7 ( 8 ) page: e016248   2017.8

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    DOI: 10.1136/bmjopen-2017-016248

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  306. Calcineurin Inhibitor-Induced Pain Syndrome in ABO-Incompatible Living Kidney Transplantation: A Case Report

    Ishida S., Kato M., Fujita T., Funahashi Y., Sassa N., Matsukawa Y., Yoshino Y., Yamamoto T., Katsuno T., Maruyama S., Gotoh M.

    TRANSPLANTATION PROCEEDINGS   Vol. 49 ( 1 ) page: 163-166   2017

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    DOI: 10.1016/j.transproceed.2016.11.007

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  307. Prognostic Value of Reduced Left Ventricular Ejection Fraction at Start of Hemodialysis Therapy on Cardiovascular and All-Cause Mortality in End-Stage Renal Disease Patients. Reviewed

    Yamada S, Ishii H, Takahashi H, Aoyama T, Morita Y, Kasuga H, Kimura K, Ito Y, Takahashi R, Toriyama T, Yasuda Y, Hayashi M, Kamiya H, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T.

    Clinical journal of the American Society of Nephrology   Vol. 5 ( 10 ) page: 1793-8   2010.7

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  308. Acute kidney injury presenting a feature of leukemic infiltration during therapy for chronic myelogenous leukemia. Reviewed

    Yuzawa Y, Sato W, Masuda T, Hamada Y, Tatematsu M, Yasuda Y, Ozaki T, Ito I, Mizuno M, Maruyama S, Ito Y, Matsuo S

    Internal Medicine   Vol. 49 ( 12 ) page: 1139-42   2010.6

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  309. Effects of oral cilostazol 100 mg BID on long-term patency after percutaneous transluminal angioplasty in patients with femoropopliteal disease undergoing hemodialysis: a retrospective chart review in Japanese patients. Reviewed

    Ishii H, Kumada Y, Toriyama T, Aoyama T, Takahashi H, Tanaka M, Kamoi D, Kawamura Y, Yamada S, Hayashi M, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T.

    Clinical therapeutics   Vol. 32 ( 1 ) page: 24-33   2010.6

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  310. Circulating progenitor cell count for cardiovascular risk stratification: a pooled analysis. Reviewed

    Fadini GP, Maruyama S, Ozaki T, Taguchi A, Meigs J, Dimmeler S, Zeiher AM, de Kreutzenberg S, Avogaro A, Nickenig G, Schmidt-Lucke C, Werner N.

    PLoS One   Vol. 5 ( 7 ) page: e11488   2010.6

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  311. *Tissue-type plasminogen activator deficiency attenuates peritoneal fibrosis in mice. Reviewed

    Kurata K, Maruyama S, Kato S, Sato W, Yamamoto J, Ozaki T, Nitta A, Nabeshima T, Morita Y, Mizuno M, Ito Y, Yuzawa Y, Matsuo S.

    American journal of physiology-Renal physiology   Vol. 297 ( 6 ) page: F1510-7   2009.12

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  312. Successful cross-breeding of cloned pigs expressing endo-beta-galactosidase C and human decay accelerating factor. Reviewed

    Yazaki S, Iwamoto M, Onishi A, Miwa Y, Suzuki S, Fuchimoto D, Sembon S, Furusawa T, Hashimoto M, Oishi T, Liu D, Nagasaka T, Kuzuya T, Maruyama S, Ogawa H, Kadomatsu K, Uchida K, Nakao A, Kobayashi T

    Xenotransplantation   Vol. 16 ( 6 ) page: 511-21   2009.9

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  313. Prognostic values of C-reactive protein levels on clinical outcome after implantation of sirolimus-eluting stents in patients on hemodialysis. Reviewed

    Ishii H, Toriyama T, Aoyama T, Takahashi H, Amano T, Hayashi M, Tanaka M, Kawamura Y, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T.

    Circulation: Cardiovascular Interventions   Vol. 2 ( 6 ) page: 513-518   2009.9

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  314. Aortic valvular calcification predicts restenosis after implantation of drug-eluting stents in patients on chronic haemodialysis. Reviewed

    Ishii H, Kumada Y, Toriyama T, Aoyama T, Takahashi H, Amano T, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T.

    Nephrology dialysis transplantation   Vol. 24 ( 5 ) page: 1562-1567   2009.8

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  315. A murine model of neonatal diabetes mellitus in Glis3-deficient mice. Reviewed

    Watanabe N, Hiramatsu K, Miyamoto R, Yasuda K, Suzuki N, Oshima N, Kiyonari H, Shiba D, Nishio S, Mochizuki T, Yokoyama T, Maruyama S, Matsuo S, Wakamatsu Y, Hashimoto H.

    FEBS Letter   Vol. 583 ( 12 ) page: 2108-13   2009.6

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  316. *Novel culture system of mesenchymal stromal cells from human subcutaneous adipose tissue. Reviewed

    Iwashima S, Ozaki T, Maruyama S, Saka Y, Kobori M, Omae K, Yamaguchi H, Niimi T, Toriyama K, Kamei Y, Torii S, Murohara T, Yuzawa Y, Kitagawa Y, Matsuo S.

    Stem Cells and Development   Vol. 18 ( 4 ) page: 533-43   2009.5

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  317. *The growth factor midkine regulates the renin-angiotensin system in mice. Reviewed

    Hobo A, Yuzawa Y, Kosugi T, Kato N, Asai N, Sato W, Maruyama S, Ito Y, Kobori H, Ikematsu S, Nishiyama A, Matsuo S, Kadomatsu K.

    Journal of Clinical Investigation   Vol. 19 ( 6 ) page: 1616-25   2009.5

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  318. Lymphatic vessels develop during tubulointerstitial fibrosis. Reviewed

    Sakamoto I, Ito Y, Mizuno M, Suzuki Y, Sawai A, Tanaka A, Maruyama S, Takei Y, Yuzawa Y, Matsuo S.

    Kidney International   Vol. 75 ( 8 ) page: 828-823   2009.4

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  319. Kidney regeneration through nephron neogenesis in medaka. Reviewed

    Watanabe N, Kato M, Suzuki N, Inoue C, Fedorova S, Hashimoto H, Maruyama S, Matsuo S, Wakamatsu Y.

    Development Growth and Differentiation   Vol. 51 ( 2 ) page: 135-143   2009.2

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  320. Removal of blood group A/B antigen in organs by ex vivo and in vivo administration of endo-beta-galactosidase (ABase) for ABO-incompatible transplantation. Reviewed

    Kobayashi T, Liu D, Ogawa H, Miwa Y, Nagasaka T, Maruyama S, Li YT, Onishi A, Iwamoto M, Kuzuya T, Kadomatsu K, Uchida K, Nakao A.

    Transplant immunology   Vol. 20 ( 3 ) page: 132-8   2008.10

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  321. Efficiency of laparoscopic-assisted renal biopsy. Reviewed

    Anas CM, Hattori R, Morita Y, Matsukawa Y, Komatsu T, Yoshino Y, Maruyama S, Yuzawa Y, Matsuo S, Gotoh M.

    Clinical Nephrology   Vol. 70 ( 3 ) page: 203-9   2008.9

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  322. Algorithm of early detection and diagnosis of CKD Reviewed

    Matsuo S, Yasuda Y, Maruyama S, Yuzawa Y.

    Nippon Rinsho.   Vol. 66 ( 9 ) page: 1707-12   2008.9

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  323. Low circulating CD34+ cell count is associated with poor prognosis in chronic hemodialysis patients. Reviewed

    Shoichi Maruyama1, Akihiko Taguchi2, Shigejiro Iwashima1, Takenori Ozaki1, Kaoru Yasuda1, Akie Kikuchi-Taura3, Toshihiro Soma3, Hideki Ishii4, Toyoaki Murohara4, Hiroshi Takahashi5, Hirotake Kasuga5, Yoshitaka Kumada6, Takanobu Toriyama5, Yasuhiko Ito1, Hirohisa Kawahara5, Yukio Yuzawa1 and Seiichi Matsuo1

    Kidney international   Vol. 74 ( 12 ) page: 1603-9   2008.8

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  324. Intrarenal administration of recombinant human soluble thrombomodulin ameliorates ischaemic acute renal failure. Reviewed

    Ozaki T, Anas C, Maruyama S, Yamamoto T, Yasuda K, Morita Y, Ito Y, Gotoh M, Yuzawa Y, Matsuo S.

    Nephrology dialysis transplantation   Vol. 23 ( 1 ) page: 110-119   2008.6

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  325. *Lipid droplet-associated proteins protect renal tubular cells from fatty acid-induced apoptosis. Reviewed

    Urahama Y, Ohsaki Y, Fujita Y,Maruyama S, Yuzawa Y, Matsuo S, Fujimoto T.

    Ameircan journal of Pathology   Vol. 173 ( 5 ) page: 1286-1294   2008

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  326. Long-term outcome of percutaneous transluminal angioplasty in chronic haemodialysis patients with peripheral arterial disease. Reviewed

    Kumada Y, Aoyama T, Ishii H, Tanaka M, Kawamura Y, Takahashi H, Toriyama T, Aoyama T, Yuzawa Y, Maruyama S, Matsuo S, Murohara T.

    Nephrology dialysis transplantation   Vol. 10   page: 1-6   2008

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  327. Overexpression of Calmodulin in Pancreatic {beta} Cells Induces Diabetic Nephropathy. Reviewed

    Yuzawa Y, Niki I, Kosugi T, Maruyama S, Yoshida F, Takeda M, Tagawa Y, Kaneko Y, Kimura T, Kato N, Yamamoto J, Sato W, Nakagawa T, Matsuo S.

    Journal of the American Society of Nephrology   Vol. 19 ( 9 ) page: 1701-1711   2008

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  328. Cilostazol Improves Long-Term Patency after Percutaneous Transluminal Angioplasty in Hemodialysis Patients with Peripheral Artery Disease. Reviewed

    Ishii H, Kumada Y, Toriyama T, Aoyama T, Takahashi H, Yamada S, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T.

    Clinical journal of the American Society of Nephrology   Vol. 3 ( 4 ) page: 1034-1040   2008

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  329. Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model. Reviewed

    Nishimura H, Ito Y, Mizuno M, Tanaka A, Morita Y, Maruyama S, Yuzawa Y, Matsuo S.

    American journal of physiology. Renal physiology   Vol. 294   page: F1084-1093   2008

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  330. Sirolimus-eluting stents vs bare metal stents for coronary intervention in Japanese patients with renal failure on hemodialysis. Reviewed

    Aoyama T, Ishii H, Toriyama T, Takahashi H, Kasuga H, Murakami R, Amano T,Uetani T, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T

    Circulation journal   Vol. 72 ( 1 ) page: 56-60   2008

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  331. High mobility group box chromosomal protein 1 in patients with renal diseases. Reviewed

    Fumihiko Sato, Shoichi Maruyama, Hiroki Hayashi, Izumi Sakamoto, Shingo Yamada, Tomonori Uchimura, Yoshiki Morita, Yasuhiko Ito, Yukio Yuzawa, Ikuro Maruyama, Seiichi Matsuo

    Nephron Clinical Practice   Vol. 108 ( 3 ) page: c194-c201   2008

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  332. Alternative strategy for overcoming ABO incompatibility. Reviewed

    Kobayashi T, Liu D, Ogawa H, Miwa Y, Nagasaka T, Maruyama S, Li YT, Onishi A, Kuzuya T, Kadomatsu K, Uchida K, Nakao A.

    Transplantation.   Vol. 83 ( 9 ) page: 1284-1286   2007.5

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  333. Effects of olprinone, a phosphodiesterase III inhibitor, on ischemic acute renal failure. Reviewed

    Anas C, Ozaki T, Maruyama S, Yamamoto T, Gotoh M, Ono Y, Matsuo S.

    Int J Urol.   Vol. 14 ( 3 ) page: 219-225   2007.5

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    OBJECTIVE: Renal ischemic reperfusion injury (IRI) is unavoidable and is still one of the major problems in renal transplantation. The aim of this study was to investigate the effects of olprinone, a phosphodiesterase III inhibitor, on renal IRI. METHODS: After a right nephrectomy, renal IRI was induced in rats. Olprinone was given in two different ways: sustained systemic administration and transient local administration to the kidney. Control rats were treated with saline. Using a magnifying endoscope, the renal blood flow speed was measured at 23 h after reperfusion. Then, blood samples were collected, and kidney specimens were taken for histological study. In order to study the mechanism, we performed in vitro experiments, using human proximal renal tubular cells (HK-2) incubated with tumor necrosis factor (TNF)-alpha along with olprinone or saline, and interleukin (IL)-8 was measured in the culture supernatant. RESULTS: In the saline group, the blood flow speed (BFS) was greatly reduced compared to that in normal kidneys. In both olprinone-treated groups, BFS of the renal microcirculation significantly increased, tubular damage and macrophage infiltration attenuated, and renal function greatly improved. Olprinone inhibited the increase in the IL-8 levels resulting from the incubation of HK-2 with TNF-alpha. CONCLUSIONS: Our study successfully demonstrates that olprinone has renoprotective properties when applied locally as well as systemically. The results suggest that olprinone might be clinically useful in renal transplantation for the donor kidney, the recipient, and even in treating acute renal failure.

  334. Efficacy of oral nicorandil in patients with end-stage renal disease: a retrospective chart review after coronary angioplasty in Japanese patients receiving hemodialysis. Reviewed

    Ishii H, Toriyama T, Aoyama T, Takahashi H, Yamada S, Kasuga H, Ichimiya S, Kanashiro M, Mitsuhashi H, Maruyama S, Matsuo S, Naruse K, Matsubara T, Murohara T.

    Clin Ther.   Vol. 29 ( 1 ) page: 110-122   2007.1

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    BACKGROUND: Patients receiving hemodialysis for end-stage renal disease (ESRD) are at high risk for death from ischemic heart disease (IHD). Nicorandil, a hybrid compound of adenosine triphosphate-sensitive potassium channel opener and nitric oxide donor, has been reported to improve the clinical prognosis of patients with IHD. OBJECTIVE: This study sought to investigate the efficacy of oral nicorandil in reducing the risks for cardiovascular events (CVEs) and CVE-related death in patients receiving hemodialysis for ESRD after undergoing percutaneous coronary intervention (PCI) for angina pectoris. METHODS: For this retrospective chart review, we used data from telephone interviews and medical charts from 3 hospitals in Japan. Data from patients aged <80 years who were receiving hemodialysis for ESRD and who had undergone successful PCI for angina between January 1999 and December 2004 were included in the analysis. Patients were stratified based on status of nicorandil treatment before PCI, as follows: patients receiving nicorandil 5 mg PO TID (the recommended dosage in Japan) for >1 month before PCI (nicorandil group) or those who did not receive nicorandil (control group). We investigated 6-year follow-up data on the primary end point, defined as CVEs (ie, unplanned hospital admission for worsening anginal status, or CVE-related death). The secondary end point was CVE-related death. After the data were initially analyzed, we performed a propensity-matched analysis to minimize selection bias. RESULTS: Data from 356 patients were included in the study (235 men, 121 women; mean [SD] age, 69 [9] years; mean [SD] weight, 52.3 [9.1] kg; nicorandil group, 198 patients; control group, 158 patients). According to the estimated propensity scores, 107 patients from each group were matched. There were no differences between the 2 groups in the baseline characteristics. On propensity-matched patient analysis, the estimated rates of patients who were CVE-free at 6 years were 3

  335. Relation between human decay-accelerating factor (hDAF) expression in pig cells and inhibition of human serum anti-pig cytotoxicity: value of highly expressed hDAF for xenotransplantation. Reviewed

    Liu D, Kobayashi T, Onishi A, Furusawa T, Iwamoto M, Suzuki S, Miwa Y, Nagasaka T, Maruyama S, Kadomatsu K, Uchida K, Nakao A.

    Xenotransplantation.   Vol. 14 ( 1 ) page: 67-73   2007.1

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    BACKGROUND: Although the successful production of alpha1,3-galactosyltransferase-knockout (GT-KO) pigs has increased expectations of clinical xenotransplantation, additional modifications of genetically engineered pigs are still being explored, because even GT-KO pigs are incapable of inhibiting the host's immunological response completely. One of the potential candidates is a complement-regulatory protein, such as human decay-accelerating factor (hDAF). However, there are few reports on how high the expression level of hDAF in pig cells would be required for suppression of complement activation. The purpose of this study was to examine the relationship between the level of hDAF expression and its inhibitory effect on human serum cytotoxicity. METHODS: An expression (pCAGGS) vector containing the hDAF gene was transfected into pig fibroblasts using an electroporation system (Gene Pulser II). Forty-eight to fifty-two hours after transfection, the cells were stained with FITC-labeled anti-hDAF antibody and then applied to the cell sorter. hDAF-transfected cells with various expression levels were collected by gating on fluorescence intensity. The level of hDAF expression was determined relative to that in human control endothelial cells. Collected cells expressing x1, x5, x10, x15 and x30 hDAF were incubated into 96-well plates for 16 h, and the cells were subjected to 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide (MTT) assay. RESULTS: hDAF expression levels in transfected cells at the time of MTT assay (16 h after sorting) were comparable to those immediately after sorting. hDAF expression in pig cells five times higher than in human endothelial cells was effective in inhibiting complement-dependent cytotoxicity of most human sera. However, 15- to 30-fold expression of hDAF was required for effective inhibition of human sera with the highest cytotoxic capacity. CONCLUSIONS: A much higher level of hDAF expression in pig cells than previously considered

  336. Effects of olprinone, a phosphodiesterase III inhibitor, on ischemic acute renal failure. Reviewed

    Anas C, Ozaki T, Maruyama S, Yamamoto T, Gotoh M, Ono Y, Matsuo S

    International journal of Urology   Vol. 14 ( 3 ) page: 219-225   2007

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  337. Alternative Strategy for Overcoming ABO Incompatibility. Reviewed

    Kobayashi T, Liu D, Ogawa H, Miwa Y, Nagasaka T, Maruyama S, Li YT, Onishi A, Kuzuya T, Kadomatsu K, Uchida K, Nakao A. Related Articles, Links

    Transplantation   Vol. 83 ( 9 ) page: 1284-1286   2007

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  338. Comparison of percutaneous coronary intervention with medication in the treatment of coronary artery disease in hemodialysis patients. Reviewed

    Yasuda K, Kasuga H, Aoyama T, Takahashi H, Toriyama T, Kawade Y, Iwashima S, Yamada S, Kawahara H, Maruyama S, Yuzawa Y, Ishii H, Murohara T, Matsuo S.

    J Am Soc Nephrol.   Vol. 17 ( 8 ) page: 2322-2332   2006.8

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    It has been reported that percutaneous coronary intervention (PCI) is beneficial for coronary artery disease (CAD) among the general population. However, its effects in patients who are on hemodialysis (HD) remain unclear. A prospective cohort study was performed to clarify whether PCI has a therapeutic advantage over medical therapy among HD patients with CAD. A follow-up study to 5 yr was conducted among 259 HD patients with ischemic heart disease. Mean follow-up was 39 mo. Patients were divided into three groups: 122 patients without significant stenosis, 88 patients who had significant stenosis and were treated with PCI, and 49 patients who had significant stenosis and were treated with medication only. The primary end point was cardiac death, and the secondary end point was all-cause death. The results showed that the 5-yr cardiac survival rate was 41.6% in the medication group, 77.1% in the PCI group (P = 0.0006), and 84.5% in the nonstenosis group (P < 0.0001). The 5-yr all-cause survival rate was 19.3% in the medication group, 48.4% in the PCI group (P = 0.004), and 64.3% in the nonstenosis group (P < 0.0001). Even after adjustment for other risk factors, effects of PCI on the risk for cardiac and all-cause death remained significant and independent (odds ratio 0.14; 95% confidence interval 0.08 to 0.25, P = 0.0006; and odds ratio 0.37; 95% confidence interval 0.26 to 0.54, P = 0.0062, respectively). Results were consistent when the therapeutic effect of PCI or medication was analyzed using propensity-matched patients. These data suggested that PCI could improve the prognosis of HD patients with CAD. PCI would be recommended for HD patients with CAD.

  339. Comparison of percutaneous coronary intervention with medication in the treatment of coronary artery disease in hemodialysis patients. Reviewed

    Yasuda K, Kasuga H, Aoyama T, Takahashi H, Toriyama T, Kawade Y, Iwashima S, Yamada S, Kawahara H, Maruyama S, Yuzawa Y, Ishii H, Murohara T, Matsuo S

    Journal of the American Society of Nephrology   Vol. 17 ( 8 ) page: 2322-2332   2006.8

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  340. Gene therapy for interstitial renal disease Reviewed

    Maruyama S.

    Nippon Rinsho   Vol. 66 ( 2 ) page: 662-6   2006.2

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  341. Geranylgeranylacetone ameliorates ischemic acute renal failure via induction of Hsp70. Reviewed

    Suzuki S, Maruyama S, Sato W, Morita Y, Sato F, Miki Y, Kato S, Katsuno M, Sobue G, Yuzawa Y, Matsuo S.

    Kidney Int.   Vol. 67 ( 6 ) page: 2210-2220   2005.6

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    BACKGROUND: Heat shock proteins (HSPs) are well known as cytoprotective proteins. Geranylgeranylacetone (GGA), an antiulcer agent, has recently been shown to induce Hsp70. This study was performed to investigate the renoprotective properties of GGA. METHODS: The effect of GGA on the induction of the major HSPs (Hsp90, Hsp70, Hsc70, Hsp60, and Hsp32) was studied in the rat kidney or rat primary cultures of tubular epithelial cells (R-TECs) by Western blot. Localization of Hsp70 was determined by immunohistochemistry. The renoprotective effects of GGA were studied using a rat model of ischemia/reperfusion (I/R) injury. GGA (400 mg/kg), GGA with quercetin pretreatment (100 mg/kg), or a vehicle was given to rats 24 hours and again 1 hour prior to the induction of I/R injury. Rats were sacrificed at 24 hours after reperfusion. Histologic analyses and terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine triphosphate (dUTP) nick-end labeling (TUNEL) assay were performed. Blood urea nitrogen (BUN) and serum creatinine was also measured. The cytoprotective properties of GGA were also studied in vitro by treating R-TECs with GGA (10 mumol/L) or a vehicle, followed by incubation in culture medium with oxidative stress condition (0.5 mmol/L hydrogen peroxide) or ischemic condition (2 nmol/L NaCN and 20 mmol/L 2-deoxyglucose in the absence of medium glucose). RESULTS: Oral administration of GGA induced Hsp70 expression in the kidney (which peaked at 24 hours) but did not induce Hsp90, Hsc70, Hsp60, or Hsp32. The induction of Hsp70 was blocked by quercetin. Immunohistochemistry showed that Hsp70 was localized mainly in the tubular epithelial cells. Preconditioning rats with GGA significantly decreased BUN and serum creatinine levels after I/R injury. Histologic examination revealed that GGA significantly attenuated tubular damage and macrophage infiltration. The number of TUNEL-positive cells also decreased significantly in the GGA group. Quercetin, an inhibitor of H

  342. Geranylgeranylacetone ameliorates ischemic acute renal failure via induction of Hsp70. Reviewed

    Suzuki S, Maruyama S, Sato W, Morita Y, Sato F, Miki Y, Kato S, Katsuno M, Sobue G, Yuzawa Y, Matsuo S

    Kidney international   Vol. 67 ( 6 ) page: 2210-2220   2005.6

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  343. Caveolin-1 in mesangial cells suppresses MAP kinase activation and cell proliferation induced by bFGF and PDGF. Reviewed

    Fujita Y, Maruyama S, Kogo H, Matsuo S, Fujimoto T.

    Kidney Int.   Vol. 66 ( 5 ) page: 1794-1804   2004.11

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    BACKGROUND: Caveolin is a principal component of caveolae and regulates signaling in caveolae. Mesangial cells contain many caveolae, and thus manipulation of caveolin-1 expression level might be useful to control mesangial cell proliferation, which is an important aggravating factor in many renal diseases. METHODS: In the present study, we transfected caveolin-1 cDNA to rat primary mesangial cells and MES13 cells, and examined the effects on Raf-extracellular signal-regulated protein kinase (ERK) kinase (MEK)-mitogen-activated protein (MAP) kinase pathway and cell proliferation stimulated by basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF). Activity of the kinases was analyzed by immunofluorescence labeling and Western blot analysis. RESULTS: The overexpression of caveolin-1 inhibited the activation of Raf-1, MEK-1/2, and MAP kinase induced by either bFGF or PDGF. Furthermore, it suppressed the cell proliferation caused by the cytokines. The effect was specific to the Raf-MEK-MAP kinase pathway, because it did not influence activation of Smad2 induced by transforming growth factor-beta (TGF-beta). On the contrary, expression of a dominant-negative caveolin mutant, DGV-caveolin, augmented activation of MAP kinase. CONCLUSION: The result showed that overexpression of caveolin-1 in mesangial cells suppresses MAP kinase activation and cell proliferation induced by bFGF and PDGF. Because bFGF and PDGF are two major cytokines involved in the mesangioproliferative nephritis, the result implies that introduction of caveolin-1 expression vector is a potential therapeutic tool for the disease.

  344. Caveolin-1 in mesangial cells suppresses MAP kinase activation and cell proliferation induced by bFGF and PDGF. Reviewed

    Fujita Y, Maruyama S, Kogo H, Matsuo S, Fujimoto T

    Kidney international   Vol. 66 ( 5 ) page: 1794-1804   2004.11

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  345. In vivo gene transfer of endo-beta-galactosidase C removes alphaGal antigen on erythrocytes and endothelial cells of the organs. Reviewed

    Miki Y, Maruyama S, Liu D, Kobayashi T, Sato F, Shimizu H, Kato S, Sato W, Morita Y, Yuzawa Y, Muramatsu T, Matsuo S.

    Xenotransplantation.   Vol. 11 ( 5 ) page: 444-451   2004.9

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    BACKGROUND: The presence of Galalpha1-3Galbeta1-4GlcNAc (alphaGal) in pigs is a formidable barrier for pig-to-primate xenotransplantation. We have reported that administration of recombinant endo-beta-galactosidase C (EndoGalC) removes alphaGal on porcine erythrocytes and kidneys. The present study examined the effects of EndoGalC gene therapy on alphaGal suppression. METHODS: Naked plasmid DNA encoding Igkappa-EndoGalC was given to rats by rapid tail vein injection. The expression of alphaGal in the heart and kidney were studied by lectin staining followed by computer-assisted quantitative analyses. alphaGal expression on erythrocytes was determined by flow cytometric analyses. Enzymatic activity of EndoGalC in the serum was also determined by evaluating the capacity of EndoGalC in removing alphaGal epitopes. Elimination of alphaGal was further studied by injecting antibodies against alphaGal to rats 2 days after the gene transfer. RESULTS: Administration of 1 mg of Igkappa-EndoGalC/pCAGGS plasmid eliminated alphaGal from the vascular endothelium of the heart and kidney on day 1 and day 2. Between days 4 and 7, alphaGal started to reappear, but remained suppressed. No serious adverse effect was observed in rats treated with EndoGalC. Flow cytometric analyses showed that EndoGalC digested 97% of alphaGal on erythrocytes when measured 4 days after the gene transfer. Enzymatic activity of EndoGalC in the serum peaked on day 1, and significant levels were still observed on day 7. When antibodies against alphaGal were given, rats treated with EndoGalC showed no change, while all control rats died within 40 min. CONCLUSIONS: The present study demonstrates the potential of an EndoGalC gene transfer, using a hydrodynamics-based delivery system, in eliminating alphaGal from endothelial cells in vivo. The results also ensured that EndoGalC is not harmful suggesting that the production of pigs overexpressing EndoGalC would be a reasonable alternative to pigs deficient in alph

  346. Endotoxin-induced chemokine expression in murine peritoneal mesothelial cells: the role of toll-like receptor 4. Reviewed

    Kato S, Yuzawa Y, Tsuboi N, Maruyama S, Morita Y, Matsuguchi T, Matsuo S.

    J Am Soc Nephrol.   Vol. 15 ( 5 ) page: 1289-1299   2004.5

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    Acute peritonitis, in which peritoneal mesothelial cells are directly exposed to bacterial components, is a major cause of peritoneal dysfunction in continuous ambulatory peritoneal dialysis patients. We have previously shown that Toll-like receptors (TLR) are expressed in kidney cells, and LPS induces TLR4-dependent chemokine production in tubular epithelial cells. The present work was designed to investigate the involvement of TLR, especially TLR4, in the lipid A-mediated chemokine production by murine peritoneal mesothelial cells (MPMC). A primary cell culture of MPMC from C3H/HeN mice (wild-type mice; LPS sensitive) and from C3H/HeJ mice (containing a point mutation of TLR4; LPS hyposensitive) was established. The expression profile of the TLR family and their accessory molecules, CD14 and MD-2, which are requisite for the LPS signaling pathway, was examined by RT-PCR, Northern blot test, and immunohistochemical staining. Synthetic lipid A-mediated chemokine production by MPMC was studied. The involvement of MAP kinase family (ERK, JNK, and p38 mitogen-activated protein kinase) and nuclear factor (NF)-kappaB in these processes was also studied. MPMC constitutively express TLR4, CD14, and MD-2. A prominent induction of monocyte chemotactic protein-1 (MCP-1) and macrophage inflammatory protein (MIP)-2 by MPMC was detected after lipid A stimulation and was strictly dependent on TLR4. Furthermore, TLR4-dependent chemokine production followed by leukocyte influx into the peritoneal cavity was also confirmed in vivo after stimulation with LPS. mRNA expression of MCP-1 was abolished by NF-kappaB inhibition, but were not affected by the inhibition of ERK, JNK, or p38. As compared with MCP-1, MIP-2 mRNA expression was inhibited by a high dose of curcumin but not by NF-kappaB decoy oligodeoxynucleotide and individual inhibitions of MAP kinase, suggesting that the additional signaling pathway with NF-kappaB might be involved in mRNA expression of MIP-2. These show that TLR

  347. The nephrotoxicity of Aristolochia manshuriensis in rats is attributable to its aristolochic acids. Reviewed

    Liu MC, Maruyama S, Mizuno M, Morita Y, Hanaki S, Yuzawa Y, Matsuo S.

    Clin Exp Nephrol.   Vol. 7 ( 3 ) page: 186-194   2003.9

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    BACKGROUND: Although Aristolochia manshuriensis (AM), which was incriminated in the Japanese variety of Chinese herbs nephropathy, has been recently shown to be nephrotoxic in rats, less is known about whether this toxicity is attributable to its aristolochic acids (AA). We compared the renal effect of AM with that of Akebia quinata (AQ), which has similar components to AM but is free of AA; we also compared this effect of AM with that of pure AA, and studied its possible mechanism. METHODS: In study 1, rats were divided into four groups. Each group was orally given either 0.4 g of AM, 4 g of AM, or 4 g of AQ per day, or vehicle, for 5 days. In study 2, rats were given 4 g of AM (which contained 4 mg of AA), or 4 mg of pure AA per day, or vehicle, for 5 days. Renal function, and renal histology were evaluated on day 5 in study 1 and on days 1, 3, 5, and 14 in study 2. In study 2, terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) and proliferating cell nuclear antigen (PCNA) staining were also performed. In study 3, rats were treated in the same way as in study 2, but were all killed on day 5. Concentrations of AA (I + II) were measured in serum and urine in study 2, and in the kidney, lung, heart, liver, and spleen in study 3. RESULTS: In study 1, only the rats that received 4 g/day of AM developed tubular necrosis, azotemia, proteinuria, and glucosuria. In study 2, both AM- and AA-treated rats showed progressive tubular damage, decreased renal function, and increased urinary protein excretion. The degree of these alterations was comparable in the AM and AA groups. Moreover, the concentrations of AA (I + II), in serum, urine, and kidney were also comparable in the AM- and AA-treated rats. High levels of AA were detected in the lung and kidney. Apoptotic tubular cells increased on day 5 and had decreased by day 14 after the withdrawal of AM or AA. Meanwhile, proliferating tubular cells progressively increased from day 3 to day 14. C

  348. Anti-monocyte chemoattractant protein-1 gene therapy attenuates renal injury induced by protein-overload proteinuria. Reviewed

    Shimizu H, Maruyama S, Yuzawa Y, Kato T, Miki Y, Suzuki S, Sato W, Morita Y, Maruyama H, Egashira K, Matsuo S.

    J Am Soc Nephrol.   Vol. 14 ( 6 ) page: 1496-1505   2003.6

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    It has been postulated that protein filtered through glomeruli activates tubular epithelial cells, which secrete vasoactive and inflammatory substances including chemokines, leading to tubulointerstitial renal injury. The present study was designed to investigate the role of monocyte chemoattractant protein-1 (MCP-1) in this process and to evaluate the effectiveness of a kidney-targeted gene transfer technique using hydrodynamic pressure. Naked plasmid encoding 7ND (an MCP-1 antagonist) or a control plasmid was introduced into the left kidney of rats. Three days after gene transfer (day 0), intraperitoneal administration of bovine serum albumin (10 mg/g body wt per day) was started and continued for 14 or 21 d. RT-PCR showed that 7ND mRNA was expressed only in the gene-transfected kidney. Immunostaining showed that 7ND protein was localized in the interstitial cells. Macrophage infiltration was significantly reduced in the left kidney of rats treated with 7ND on days 14 and 21. In the right kidney, such effects were not observed. 7ND also attenuated tubular damage and decreased the number of apoptotic cells. Computer-assisted analysis revealed that the areas positively stained for alpha-smooth muscle actin (alpha SMA), fibronectin-EDA, type I collagen, and collagen fibrils were significantly reduced in the 7ND-treated kidney on day 21. Furthermore, 7ND gene therapy significantly reduced MCP-1 and TGF-beta 1 mRNA expression. These results demonstrate that MCP-1 plays an important role in the development of tubulointerstitial inflammation, tubular damage, and fibrosis induced by proteinuria. The fact that 7ND gene therapy had little effect on the contralateral kidney indicates that 7ND acted locally. This strategy may have a potential usefulness as a gene therapy against tubulointerstitial renal injury.

  349. Non-dipping is a potent predictor of cardiovascular mortality and is associated with autonomic dysfunction in haemodialysis patients. Reviewed

    Liu M, Takahashi H, Morita Y, Maruyama S, Mizuno M, Yuzawa Y, Watanabe M, Toriyama T, Kawahara H, Matsuo S.

    Nephrol Dial Transplant.   Vol. 18 ( 3 ) page: 563-569   2003.5

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    BACKGROUND: Lack of nocturnal blood pressure (BP) fall (non-dipping) is common among haemodialysis (HD) patients, but much less is known regarding its association with cardiovascular (CV) disease morbidity and mortality. METHODS: Eighty HD patients initially underwent 24 h ambulatory BP monitoring (ABPM), and then they were defined as either 'dippers' (n=24, nocturnal BP fall > or = 10%) or 'non-dippers' (n=56, fall <10%). Coronary angiography was performed in the patients who had signs and/or symptoms of coronary artery disease (CAD). Twenty-four hour ambulatory ECG was recorded in 20 dippers and 20 non-dipper HD patients, and in 20 normal subjects. All patients were followed for up to 5.8 years (33.0+/-19.1 months). The outcome events studied were the hospitalisations due to CV diseases and CV death. RESULTS: Compared with dippers, non-dippers initially had a higher incidence of coronary artery stenosis (P<0.05) along with left ventricular asynergy (both Ps<0.01). The circadian rhythm of autonomic function was impaired in non-dippers. The incidences of CV events and CV deaths were 3.5 and 9 times higher in non-dippers than in dippers. The cumulative CV event-free survival and CV survival rates were lower in non-dippers than in dippers (P=0.02 and P=0.005, respectively). Based on Cox analysis, non-dipping was associated positively with CV events and CV mortality [hazard ratio (HR) 2.46, 95% CI 1.02-5.92, P=0.038 and HR 9.62, 95% CI 1.23-75.42, P=0.031, respectively]. Meanwhile, nocturnal systolic BP fall, diurnal systolic BP and diurnal pulse pressure were negatively associated with CV event/death. The clinic BP was not associated with CV event/death. CONCLUSIONS: The non-dipping phenomenon is closely related to a high incidence of CV diseases, a poor long-term survival and profound autonomic dysfunction. ABPM is useful in predicting long-term CV prognosis in HD patients.

  350. Proteinuria and tubulointerstitial injury: the causative factors for the progression of renal diseases. Reviewed

    Matsuo S, Morita Y, Maruyama S, Manchang L, Yuzawa Y.

    Contrib Nephrol.   Vol. 139   page: 20-31   2003

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  351. P-selectin-dependent macrophage migration into the tubulointerstitium in unilateral ureteral obstruction. Reviewed

    Naruse T, Yuzawa Y, Akahori T, Mizuno M, Maruyama S, Kannagi R, Hotta N, Matsuo S.

    Kidney Int.   Vol. 62 ( 1 ) page: 94-105   2002.7

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    BACKGROUND: Interstitial infiltration of macrophages (M&oslash;) is one of the main causal factors for the tubulointerstitial injury. However, precise mechanisms of M&oslash; infiltration into tubulointerstitium have not been fully explored. The purposes of this study were to assess the role of selectins in the acute infiltration of M&oslash; in rats with unilateral ureteral obstruction (UUO) and to evaluate the role of vasa recta, that is, whether they facilitate massive influx of M&oslash; into the interstitium by functioning as specialized vessels. METHODS: To evaluate the role of selectins in M&oslash; infiltration into tubulointerstitium, the expression of selectins and L-selectin ligands was examined by immunohistochemistry and immunoelectron microscopy. The functional role of P-selectin in vasa recta was studied by Stamper-Woodruff assay, in vivo p-M&oslash; migration assay and in vivo blocking experiments with the monoclonal antibody (mAb) ARP2-4. RESULTS: Selective expression of P-selectin was detected in vasa recta as early as one hour after UUO, and the expression increased thereafter for 96 hours. In contrast, endothelial expression of L-selectin ligands and E-selectin were not detectable. In the Stamper-Woodruff assay on kidney sections of rats with UUO, the adhesion of isolated rat peritoneal M&oslash; (p-M&oslash;) to vasa recta was significantly inhibited by the mAb ARP2-4 (P-selectin blocker; P < 0.01), but not by mAb ARE-5 (E-selectin blocker) or rLECIg (rat L-selectin chimeric protein). In the in vivo transfer experiments with fluorescein-labeled p-M&oslash; into rats 48 hours after UUO, labeled p-M&oslash; had accumulated around vasa recta at three minutes and had infiltrated predominantly into the outer medulla at 180 minutes. The number of labeled p-M&oslash; was reduced when the rats were pretreated with ARP2-4 (P < 0.01). Finally, ARP2-4 (10 mg/kg), injected 15 minutes before UUO, reduced the number of infiltrated M&oslash; (P < 0.01). CONCLU

  352. Effects of human soluble thrombomodulin on experimental glomerulonephritis. Reviewed

    Ikeguchi H, Maruyama S, Morita Y, Fujita Y, Kato T, Natori Y, Akatsu H, Campbell W, Okada N, Okada H, Yuzawa Y, Matsuo S.

    Kidney Int.   Vol. 61 ( 2 ) page: 490-501   2002.2

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    BACKGROUND: Coagulation and inflammation are both important processes that contribute to glomerular injury. The present study was performed to evaluate the effects of recombinant human soluble thrombomodulin (RHS-TM) in a lethal model of thrombotic glomerulonephritis and to investigate the possible mechanisms. METHODS: Thrombotic glomerulonephritis was induced in rats by administration of lipopolysaccharide and rabbit anti-rat glomerular basement membrane antibody. One hour later, RHS-TM or heparin was administered, and the histological findings, renal functions, and coagulation parameters were evaluated. To evaluate the contribution of carboxypeptidase R (CPR) to the results obtained in rats treated with RHS-TM, plasma CPR levels were measured. Then, carboxypeptidase inhibitor (CPI), which prevents the function of CPR, was administered. RESULTS: Massive glomerular thrombosis and lung hemorrhage developed within five hours of disease induction, and all rats died within 24 hours. RHS-TM (3 mg/kg) prevented the progression of the disease and all rats survived. Heparin (250 U/kg/h) showed similar anti-thrombotic effect, but induced massive hemorrhage in the lungs or stomach. RHS-TM attenuated leukocyte/neutrophil infiltration in the glomerulus but heparin did not, suggesting that RHS-TM has anti-inflammatory properties. CPR levels in plasma were about threefold higher in rats treated with RHS-TM compared to those in rats treated with heparin. Furthermore, the inhibitory effect of RHS-TM on leukocyte/neutrophil infiltration was significantly diminished by injection of CPI. CONCLUSION: RHS-TM effectively attenuates the injuries of thrombotic glomerulonephritis in rats. The results indicate that RHS-TM, in addition to its anti-thrombotic action, may exert its anti-inflammatory properties by converting proCPR to CPR, which then inactivates anaphylatoxins. RHS-TM is a potential novel therapeutic tool for thrombotic glomerular injury and related disorders.

  353. Membranous glomerulopathy with Bowman's capsular and tubular basement membrane deposits. Reviewed

    Markowitz GS, Kambham N, Maruyama S, Appel GB, Cohen DJ, Kim RC, Andres GA, D'Agati VD.

    Clin Nephrol.   Vol. 54 ( 6 ) page: 478-486   2000.12

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    Bowman's capsular and tubular basement membrane (TBM) deposits are an extremely unusual finding in non-lupus membranous glomerulopathy (MGN). We report three atypical cases of MGN with abundant Bowman's capsular and TBM deposits. In two cases, MGN was idiopathic; in the third case, MGN occurred in the renal allograft in the setting of HCV seropositivity. In addition to the usual glomerular capillary wall deposits, immunofluorescence and electron microscopy revealed extensive immune deposits within Bowman's capsule and TBMs, predominantly at the base of parietal and tubular epithelial cells. These cases suggest a potential pathomechanism of autoantibody to secreted epithelial antigens shared by visceral, parietal, and tubular epithelial cells. In all three cases, indirect immunofluorescence was unable to detect autoantibody to normal renal epithelial or matrix constituents. Furthermore, ELISA was unable to demonstrate circulating antibody to major extracellular matrix components. The implications of these findings for the pathogenesis of MGN are explored.

  354. Role of platelet-activating factor in functional alterations induced by xenoreactive antibodies in porcine endothelial cells. Reviewed

    Biancone L, Cantaluppi V, Segoloni G, Boccellino M, Del Sorbo L, Conaldi PG, Tjoelker LW, Maruyama S, Cantu E, Stern D, Andres G, Camussi G.

    Transplantation.   Vol. 70 ( 8 ) page: 1198-1205   2000.10

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    BACKGROUND: Platelet-activating factor (PAF) is a phospholipid mediator of inflammation which has been implicated in rejection. The interaction of anti-alpha-galactosyl natural antibodies (anti-alpha gal Abs) with endothelial cells is the initial step for the development of xenograft rejection. In our study, we stimulated porcine aortic endothelial cells (PAEC) with anti-alpha gal IgG to investigate the synthesis of PAF from PAEC and its biological consequences. METHODS AND RESULTS: PAF was extracted and chromatographically purified from cultured PAEC stimulated with baboon anti-alpha gal Abs. The Abs induced a dose-dependent synthesis of PAF peaking after 30 min of incubation, and decreasing thereafter. Concomitant cell shape change, motility, and cytoskeleton redistribution were observed. These events were prevented by addition of a panel of PAF-receptor antagonists. An SV40 T-large antigen-immortalized PAEC line was engineered to express PAF acetyl-hydrolase (PAF-AH) cDNA, the major PAF-inactivating enzyme. These transfected cells exposed to anti-alpha gal Abs showed reduced cell contraction and motility compared with empty vector-transfected cells. Moreover, in PAEC stimulated with anti-alpha gal Abs, the synthesis of PAF promoted the adhesion of a monocytic cell line as shown by the inhibitory effect of PAF-receptor antagonists and of PAF-AH expression. Finally, studies on cell monolayer demonstrated an enhanced permeability 48 hr after exposure to anti-alpha gal Abs, and this increase was prevented by PAF-inactivation and by PAF-receptor blockade. CONCLUSIONS: These results demonstrate that on stimulation with anti-alpha gal Abs, PAEC synthetize PAF which can contribute to several vascular events involved in xenograft rejection.

  355. alpha-galactosyl epitopes on glycoproteins of porcine renal extracellular matrix. Reviewed

    Maruyama S, Cantu E 3rd, Galili U, D'Agati V, Godman G, Stern DM, Andres G

    Kidney Int.   Vol. 57 ( 2 ) page: 655-663   2000.2

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    BACKGROUND: The pig is the donor animal of choice for human xenotransplantation. In the most relevant pig-to-baboon model, pig organs transplanted into baboons are hyperacutely rejected by natural xenoantibodies, which mainly bind to alpha-galactosyl (alphaGal) epitopes expressed at the surface of endothelial cells. Recent advances in controlling hyperacute rejection have led to improved survival of these xenografts, and it is now important to identify alphaGal binding sites in other cells and tissues that may be subject to immunologic attack. To this end, we have studied whether alphaGal antibodies bind to glycated proteins of the extracellular matrix in the kidney and other organs most likely to be used for human xenotransplantation. METHODS: High-titer anti-alphaGal antibodies, similar to human natural xenoantibodies, were prepared in baboons, and their reactivity with components of pig extracellular matrix was tested by serology and immunohistology. RESULTS: The antibodies recognized epitopes of immobilized murine, bovine or porcine thyroglobulin, laminin, heparan sulfate proteoglycans, and fibronectin. In sections of pig tissue, the antibodies bound to endothelial and certain epithelial cells, as shown in previous studies, and also to mesenchymal cells, basement membranes, and extracellular matrices, in which they colocalized with matrix glycoproteins, especially laminin and heparan sulfate proteoglycans. CONCLUSIONS: These results suggest that when pig xenografts can be made to survive for prolonged periods, the reactivity of alphaGal antibody with matrix molecules can induce basement membrane and matrix lesions similar to those induced in laboratory animals by antilaminin and antiheparan sulfate proteoglycans antibodies.

  356. Differential expression of alpha-GAL epitopes (Galalpha1-3Galbeta1-4GlcNAc-R) on pig and mouse organs. Reviewed

    Tanemura M, Maruyama S, Galili U

    Transplantation.   Vol. 69 ( 1 ) page: 187-190   2000.1

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    BACKGROUND: Expression of the alpha-gal epitope in mice can be completely eliminated by disruption of the alpha1,3 galactosyltransferase gene. As an initial step for assessing the feasibility of this approach in the pig, it was of interest to compare the expression of alpha-gal epitopes in pig and mouse organs. METHODS: Membranes from pig and mouse organ homogenates were analyzed for alpha-gal epitope expression by Western blots, enzyme-linked immunosorbent assay (ELISA), immunostaining of tissues, and ELISA inhibition assay. RESULTS: Immunostaining of Western blots with human anti-Gal detected alpha-gal epitopes on glycoproteins from pig organs but not on glycoproteins from the corresponding mouse organs. ELISA with membrane homogenates and immunostaining of tissue sections demonstrated a much higher binding of human anti-Gal to alpha-gal epitopes on pig membranes than on mouse membranes. ELISA inhibition assay with monoclonal anti-Gal indicated that alpha-gal epitope expression in pig organs is up to 500-fold higher than in mouse organs. CONCLUSION: Expression of alpha-gal epitopes in pig organs is many fold higher than in mouse organs. The abundance of these epitopes in pigs raises the question of whether pigs can properly develop without expression of alpha-gal epitopes.

  357. Interaction of baboon anti-alpha-galactosyl antibody with pig tissues. Reviewed

    Maruyama S, Cantu E 3rd, DeMartino C, Wang CY, Chen J, Al-Mohanna F, NakeebSM, D'Agati V, Pernis B, Galili U, Godman G, Stern DM, Andres G

    Am J Pathol.   Vol. 155 ( 5 ) page: 1635-1649   1999.11

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    As barriers to xenotransplantation are surmounted, such as suppression of hyperacute rejection allowing improved graft survival, it becomes important to define longer-term host-xenograft interactions. To this end we have prepared in baboons high titer anti-alpha-Galactosyl (alphaGal) and anti-porcine aortic endothelial cell antibodies, similar to human natural xenoantibodies and reactive with epitopes of thyroglobulin, laminin, and heparan sulfate proteoglycans. When injected into pigs with a protocol similar to that used in the rat to show the nephritogenic potential of heterologous anti-laminin and anti-heparan sulfate proteoglycan antibodies, baboon immunoglobulins bound first to renal vascular endothelium, and later to interstitial cells, especially fibroblasts and macrophages, and to antigens in basement membranes and extracellular matrix, where they colocalized with laminin- and heparan sulfate proteoglycan-antibodies, and with bound Griffonia simplicifolia B4. A similar binding was observed in other organs. The pigs did not develop an acute complement-dependent inflammation, but rather chronic lesions of the basement membranes and the extracellular matrix. Incubation of renal fibroblasts with baboon anti-alpha-Galactosyl antibodies resulted in increased synthesis of transforming growth factor-beta and collagen, suggesting a possible basis for the fibrotic response. The results demonstrate that in this experimental model a consequence of alphaGal antibody interaction with porcine tissues, is immunoreactivity with alphaGal on matrix molecules and interstitial cells, priming mechanisms leading to fibrosis resembling that in chronic allograft rejection. The possibility that similar lesions may develop in long-surviving pig xenografts is discussed.

  358. Membranous glomerulonephritis induced in the pig by antibody to angiotensin-converting enzyme: considerations on its relevance to the pathogenesis of human idiopathic membranous glomerulonephritis. Reviewed

    Maruyama S, Cantu E 3rd, Demartino C, Vladutiu A, Caldwell PR, Wang CY,D'Agati V, Godman G, Stern DM, Andres G

    J Am Soc Nephrol.   Vol. 10 ( 10 ) page: 2102-2108   1999.10

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    In the course of studies on the humoral consequences of swine to primate xenotransplantation, the investigators induced formation of glomerular subepithelial immune deposits and tubular lesions in pigs injected with heterologous antibody to angiotensin-converting enzyme. This study describes the morphology of the lesions, discusses their mechanism, explains their relevance for understanding the pathogenesis of human idiopathic membranous glomerulonephritis, and proposes future directions for investigations.

  359. Alpha-galactosyl antibody redistributes alpha-galactosyl at the surface of pig blood and endothelial cells. Reviewed

    Maruyama S, Cantu E3rd, Pernis B, Galili U, Godman G, Stern DM, Andres G

    Transpl Immunol.   Vol. 7 ( 2 ) page: 101-106   1999.6

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    The interaction of antibodies with cell surface antigens may induce redistribution of immune complexes, followed by antigen depletion, with increased resistance to injurious effect of antibody and complement (antigenic modulation). Human natural antibodies to Gal alpha 1,3Gal beta 1,4GlcNAc-R (alpha Gal) epitopes expressed at the surface of pig cells are a major obstacle to xenotransplantation. Recent studies have shown that these antibodies do not modulate alpha Gal, but the morphological consequences of the antigen-antibody interaction are unknown. Pig blood and endothelial cells, were exposed to baboon alpha-Gal antibodies, and studied by immunofluorescence and phase contrast microscopy, flow cytometry, and inhibition enzyme-linked immunosorbent assay. In cells studied at 4 degrees C or fixed, alpha Gal was diffusely expressed at the surface. After cross-linking at 37 degrees C, antigenic modulation did not occur, but granular redistribution of alpha Gal immune complexes was seen in all cell types. In other systems a similar redistribution is known to induce perturbation of the plasma membrane/cytoskeletal structure with changes in adhesive properties, gene regulation, and T cell activation, which could be important if pig xenografts will be made to survive for prolonged periods.

  360. Role of complement in acute tubulointerstitial injury of rats with aminonucleoside nephrosis. Reviewed

    Nomura A, Morita Y, Maruyama S, Hotta N, Nadai M, Wang L, Hasegawa T, Matsuo S

    Am J Pathol.   Vol. 151 ( 2 ) page: 539-547   1997.8

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    The present work was designed to elucidate the in vivo role of complement in the proteinuria-associated tubulointerstitial injury. Rats were intravenously injected with puromycin aminonucleoside, and massive proteinuria was observed within 5 days. Prominent tubulointerstitial injury characterized by proximal tubular degeneration, tubular dilatation, and leukocyte infiltration were observed 7 days after injection. C3 and C5b-9 were observed in the luminal side of proximal tubular cells. Renal function, assessed by inulin and para-aminohippurate clearance, was significantly decreased. To-assess the role of complement in this model, rats were injected with either cobra venom factor or soluble recombinant human complement receptor type 1 starting at day 3. These manipulations significantly improved tubulointerstitial pathology and para-aminohippurate clearance without affecting the degree of proteinuria. Deposition of C3 and C5b-9 was not detected in the kidney of rats depleted of complement by cobra venom factor. In rats treated with soluble complement receptor, C3 was still detected in the tubules, but deposition of C5b-9 was not observed. Soluble complement receptor was detected at the site of C3 deposition and in the urine. These data strongly suggest that complement plays a pivotal role in proteinuria-associated tubulointerstitial injury and that systemic complement depletion or inhibition of complement in the tubular lumen may diminish the tubulointerstitial damage.

  361. Detection of ret homodimers in MEN 2A-associated pheochromocytomas. Reviewed

    Wada M, Asai N, Tsuzuki T, Maruyama S, Ohiwa M, Imai T, Funahashi H, Takagi H, Takahashi M

    Biochem Biophys Res Commun   Vol. 218 ( 2 ) page: 606-609   1996.1

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    Using transfection of NIH 3T3 cells, we have recently demonstrated that multiple endocrine neoplasia (MEN) 2A mutations activate the c-Ret protein by inducing its disulfide-linked homodimerization on the cell surface. To investigate whether the homodimers are present in original tumors, the expression of the c-Ret protein was analyzed in eight sporadic and two MEN 2A-associated pheochromocytomas, the latter two of which contained mutations in cysteine 618 or 634 of Ret. The c-Ret protein was expressed at variable levels in all pheochromocytomas examined. By labeling the c-Ret protein immunoprecipitated from tumor tissues with [gamma-32P]ATP in vitro, its homodimers were detected in pheochromocytomas from MEN 2A patients but not in a sporadic tumor. This result represents the first demonstration of Ret homodimers in original tumors.

  362. Germ line mutations of the ret proto-oncogene in Japanese patients with multiple endocrine neoplasia type 2A and type 2B. Reviewed

    Maruyama S, Iwashita T, Imai T, Funahashi H, Ceccherini I, Luo Y, Romeo G, Matsuo S, Matsuyama M, Takahashi M

    Jpn J Cancer Res   Vol. 85 ( 9 ) page: 879-882   1994.9

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    We investigated mutations of the ret proto-oncogene in Japanese patients with multiple endocrine neoplasia (MEN) type 2A and type 2B. DNAs from pheochromocytomas and/or medullary thyroid carcinomas (MTCs) of five MEN 2A and three MEN 2B patients were amplified by a polymerase chain reaction (PCR) and analyzed. Tumors of four MEN 2A patients had missense mutations in Cys 634 in the extracellular domain of the ret proto-oncogene. The same mutations were detected in normal tissues of the patients, indicating that the mutations had arisen in the germ line. Using a reverse transcriptase(RT)-PCR, both normal and mutant transcripts of the ret proto-oncogene were detected in a tumor of one patient with MEN 2A mutation. In addition, three MEN 2B patients examined had the same point mutation (ATG-->ACG) at codon 918 in the tyrosine kinase domain of the ret proto-oncogene. Since all mutations identified in this study generated new restriction enzyme sites or eliminated a restriction site, the mutant alleles of affected family members could be readily detected without sequencing.

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Presentations 5

  1. Effects of olprinone, a phosphodiesterase III inhibitor, on ischemic acute renal failure.

    Int J Urol. 

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    Event date: 2007.5

    Language:English   Presentation type:Oral presentation (general)  

    OBJECTIVE: Renal ischemic reperfusion injury (IRI) is unavoidable and is still one of the major problems in renal transplantation. The aim of this study was to investigate the effects of olprinone, a phosphodiesterase III inhibitor, on renal IRI. METHODS: After a right nephrectomy, renal IRI was induced in rats. Olprinone was given in two different ways: sustained systemic administration and transient local administration to the kidney. Control rats were treated with saline. Using a magnifying e

  2. Comparison of percutaneous coronary intervention with medication in the treatment of coronary artery disease in hemodialysis patients.

    J Am Soc Nephrol. 

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    Event date: 2006.8

    Language:English   Presentation type:Oral presentation (general)  

    It has been reported that percutaneous coronary intervention (PCI) is beneficial for coronary artery disease (CAD) among the general population. However, its effects in patients who are on hemodialysis (HD) remain unclear. A prospective cohort study was performed to clarify whether PCI has a therapeutic advantage over medical therapy among HD patients with CAD. A follow-up study to 5 yr was conducted among 259 HD patients with ischemic heart disease. Mean follow-up was 39 mo. Patients were divid

  3. Geranylgeranylacetone ameliorates ischemic acute renal failure via induction of Hsp70.

    Kidney Int. 

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    Event date: 2005.6

    Language:English   Presentation type:Oral presentation (general)  

    BACKGROUND: Heat shock proteins (HSPs) are well known as cytoprotective proteins. Geranylgeranylacetone (GGA), an antiulcer agent, has recently been shown to induce Hsp70. This study was performed to investigate the renoprotective properties of GGA. METHODS: The effect of GGA on the induction of the major HSPs (Hsp90, Hsp70, Hsc70, Hsp60, and Hsp32) was studied in the rat kidney or rat primary cultures of tubular epithelial cells (R-TECs) by Western blot. Localization of Hsp70 was determined by

  4. Caveolin-1 in mesangial cells suppresses MAP kinase activation and cell proliferation induced by bFGF and PDGF.

    Kidney Int. 

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    Event date: 2004.11

    Language:English   Presentation type:Oral presentation (general)  

    BACKGROUND: Caveolin is a principal component of caveolae and regulates signaling in caveolae. Mesangial cells contain many caveolae, and thus manipulation of caveolin-1 expression level might be useful to control mesangial cell proliferation, which is an important aggravating factor in many renal diseases. METHODS: In the present study, we transfected caveolin-1 cDNA to rat primary mesangial cells and MES13 cells, and examined the effects on Raf-extracellular signal-regulated protein kinase (ER

  5. Anti-monocyte chemoattractant protein-1 gene therapy attenuates renal injury induced by protein-overload proteinuria.

    J Am Soc Nephrol. 

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    Event date: 2003.6

    Language:English   Presentation type:Oral presentation (general)  

    It has been postulated that protein filtered through glomeruli activates tubular epithelial cells, which secrete vasoactive and inflammatory substances including chemokines, leading to tubulointerstitial renal injury. The present study was designed to investigate the role of monocyte chemoattractant protein-1 (MCP-1) in this process and to evaluate the effectiveness of a kidney-targeted gene transfer technique using hydrodynamic pressure. Naked plasmid encoding 7ND (an MCP-1 antagonist) or a con

Research Project for Joint Research, Competitive Funding, etc. 9

  1. 難治性腎疾患に関する調査研究

    2014.4 - 2017.3

    科学技術振興調整費 

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    Grant type:Competitive

  2. 非典型溶血性尿毒症症候群( aHUS )の全国調査研究

    2014.4 - 2016.3

    科学技術振興調整費 

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    Grant type:Competitive

  3. 構造ならびに機能再生を目指す脂肪組織由来幹細胞治療の開発

    2012.4 - 2017.3

    科学技術振興調整費 

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    Grant type:Competitive

  4. 糖尿病性腎症ならびに腎硬化症の診療水準向上と重症化防止にむけた調査・研究

    2012.4 - 2015.3

    科学技術振興調整費 

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    Grant type:Competitive

  5. 進行性腎障害に関する調査研究

    2011.4 - 2014.3

    科学技術振興調整費 

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    Grant type:Competitive

  6. 進行性腎障害に関する調査研究

    2009.4 - 2011.3

    科学技術振興調整費 

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    Grant type:Competitive

  7. 高齢者の切迫性尿失禁に対する膀胱壁内A 型ボツリヌストキシン注入療法の多施設臨床試験と腹圧性尿失禁に対する新規治療法の開発

    2007.4 - 2010.3

    科学技術振興調整費 

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    Grant type:Competitive

  8. 心原性脳塞栓症患者に対する細胞治療の臨床試験とその発展

    2007.4 - 2009.3

    科学技術振興調整費 

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    Grant type:Competitive

  9. 再生医療的手法による、脳血管性痴呆症および虚血性脳血管障害に対する早期診断および予防法の確立に関する研究

    2005.4 - 2006.3

    科学技術振興調整費 

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KAKENHI (Grants-in-Aid for Scientific Research) 86

  1. 糸球体周囲マクロファージは基底膜を貫く樹状突起によりポドサイト恒常性を維持する

    Grant number:22K19523  2022.6 - 2024.3

    科学研究費助成事業  挑戦的研究(萌芽)

    古橋 和拡, 丸山 彰一, 田中 章仁

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    本研究では、通常の組織学的観察で見出せず、最新のイメージング技術である生体顕微鏡・臓器透明化を用いることで初めて観察することができたマクロファージのユニークな構造と細胞間networkに関して、その生物学的意味を解明する。独自に開発した生体顕微鏡技術・組織固定技術・組織透明化技術を融合することで、本課題の科学的問いは初めて解決することができるため、独自性の高い挑戦的な研究である。本課題は組織幹細胞niche研究に細胞形態学・細胞動態学を取り入れた新たな研究フィールドを創生し、細胞形態に関わる蛋白を治療ターゲットとした新たな治療法へと発展させ、ポドサイト再生に関わる因子の同定することを目指す。

  2. aHUS早期診断及び抗補体薬の適応判断に必要な補体機能検査開発

    Grant number:22K08349  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    加藤 規利, 前田 佳哉輔, 丸山 彰一, 水野 正司, 古橋 和拡, 小杉 智規

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    aHUSは血液中ではなく、血管内皮細胞膜上での無秩序な補体活性化が問題であり、単純な採血で評価できないところに検査開発の難しさがある。我々は、2020年より開始したaHUS全国調査研究で登録のあった症例の血漿から、細胞外小胞(Exosomes)を精製し、Exosomes上の補体関連タンパクを測定し、細胞膜上の補体活性を評価する。またex vivoでaHUS患者の血漿と血管内皮細胞株との反応系にエクリズマブを添加することにより、実際に薬剤を投与する前に、治療反応性を見極める。
    我々は、非典型溶血性尿毒症症候群(aHUS)の疾患事務局を、2020年より東京大学から引き継ぎ、医療施設からの症例相談を受けるとともに、奈良県立医科大学にて開発されたヒツジ赤血球溶血試験(補体機能検査)を行ったり、抗H因子抗体(抗CFH抗体)価を測定するなどして研究、臨床の両面から知見を蓄積してきた。2020年度は62症例の臨床相談を受け、91検体の解析を行った。2021年度は65症例の臨床相談を受け、81検体の解析を行った。そして本研究を開始した2022年度は1月までに66症例の相談、77検体の解析を行った。
    当方で33例のaHUSの診断に至り、内補体関連遺伝子の病的バリアント保有例は19症例、バリアント未検出は10症例、未検査4症例であった。病的バリアント保有割合は65%(19/29)という数字は、過去の報告と同等~やや高めの値で、概ね妥当な数値と考えられる。
    19症例のバリアントの内訳は、CFH:7例、C3:9例、CD46:3例、CFI:1例(1例のC3, CD46重複例を含む)であった。世界的にはCFHの病的バリアント保有例の割合が高いが、本邦ではC3、特にC3 I1157Tバリアントの割合が高いことは、既に報告(Clin Exp Nephrol . 2018 Oct;22(5):1088-1099.)があり、同じ傾向であった。
    上記の様に、疾患の概要、特に本邦における特徴が明らかになっている。課題の1つであるヒツジ赤血球溶血試験に関しては、CFH病的バリアント保有例の7例の内、6例で測定が行われ5例で陽性と診断され、遺伝学的検査の前にaHUSへの診断につなげることが出来た。一方で他の遺伝子バリアントでは、C3 I1157Tバリアントの1例で陽性になったのみで、他のバリアントでは陰性となり、aHUSの早期診断には繋がらず、課題の残る結果であった。
    aHUSは希少疾患であり、本研究(非典型溶血性尿毒症症候群(aHUS)全国調査研究)は、現在日本で行われているaHUSの最大のコホート研究であると言える。上述のように33症例の診断に寄与してきた実績があり、本年度の症例数も例年と同じ水準~やや多めの数を記録している。aHUSのみならず他のTMA(STEC-HUS, TTP, 二次性TMA)の症例も含まれていることが、本コホート研究の強みである。つまり、aHUSの診断に寄与する検査方法を、他のTMAを引き起こす疾患と比較することができる。
    現状では血漿中のC5b-9は、エクリズマブ治療を行うと完全に抑制されるが、血漿交換を数回行った状況では、そこまで抑えられていないことがわかっている。また興味深いことに未発症者の検体でもC5b-9は基準値を上回っており、あきらかなTMAによる臓器症状がない状況においても異常値を取っていることの意義は、今後検証をしていく必要があるものと思われる。また、aHUS以外のTMAであるTTPにおいても血漿C5b-9が異常高値であったことは、C5b-9の診断的価値の検討に置いて大切な結果である。つまり補体が一義的に関与するaHUSのみならず、別要因で血管内皮細胞障害を引き起こす疾患でも、二次的に補体の活性化が起きている可能性は示唆される。これら問題点に置いて、更に症例数を重ねて検証を続けていく。
    基本的には現在のaHUS疾患事務局を通した症例の解析を続けていく。名古屋大学医学部腎臓内科学のホームページにおいて事務局の案内をするとともに、動画などの説明資材を用いて疾患の啓蒙を続ける。
    目的の検査に関しては、ある程度の数のaHUS症例、及び、STEC-HUS, TTP,
    二次性TMAの症例が蓄積した時点で、更にエクソソームの抽出を行う。またin vitroにおけるエクリズマブ抑制試験は、ヒツジ赤血球溶血試験においては既に数多く行っている。フローサイトメトリーによる解析を通して、生体内における補体活性化の量的解析、つまり定量性をもたせることによって、実臨床に置いて発症、再発診断、治療効果判定、のみならず抗C5抗体薬(エクリズマブ、ラブリズマブ)投与前に治療効果予測を行えるようになることは、医療資源の適切な利用に関わる問題として非常に重要な知見となると考える。

  3. 間葉系幹細胞カラムとiPS細胞・遺伝子編集技術を融合した新規治療システム

    Grant number:22H03087  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(B)

    古橋 和拡, 高須 正規, 平山 明由, 鈴木 洋, 丸山 彰一, 田中 章仁, 森 崇

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    これまでの間葉系幹細胞(MSC)研究を通して、臨床応用時の問題点の解決と治療特性に関わる作用機序について解明を進めてきた。循環動態が悪い際の経静脈的な細胞投与は細胞塞栓の危険があり、この問題を解決するために、新たな治療装置としてMSCカラムの開発を進めている。さらに、細胞ソースの問題を解決するため、iPS細胞からMSCを作成する研究を進めている。
    本課題では、iPS細胞、MSCカラム、解明した治療機序を融合した新規治療システムを開発し、将来的に遺伝編集技術・細胞治療が新たに創生する治療フィールドを見据えた基盤技術へと発展させる。

  4. 慢性腎臓病患者における生体内細菌叢をターゲットにした新規抗老化療法の開発

    Grant number:22K08328  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    加藤 佐和子, 丸山 彰一, 今泉 貴広, 小杉 智規

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    慢性腎臓病(CKD)患者の表現系は老化に見られる諸変化に酷似している。通常の維持血液透析患者(従来透析)と長時間透析患者、保存期腎不全患者は、尿毒症にさらされている強度や条件が異なる。尿毒症存在下において、どのような外的・内的環境負荷(Allostatic load)が免疫学的変調と慢性炎症をきたし、Microbiomeの変調をきたすのか、老化の指標となる遺伝子保護の不調(テロメア消耗)に関与しているか解析し、実際の心疾患、感染症、死亡率と比較することにより、腸内細菌叢の改善をターゲットとしたCKD患者の新規治療戦略の構築を目指すものである。
    最も深刻な尿毒症下にある従来透析療法施行中(NICE-GENEコホート研究)の患者、長時間透析により尿毒症を可及的に管理している患者(RRTRコホート研究)、保存期腎不全患者(N-KDRG)のサンプルの取集を予定通り遂行している。登録状況は順調である。NICE-GENEコホート研究では現在までに約300名の登録、RRTRコホート研究では約200名の登録(全体で約300名登録のうち長時間透析200名)、N-KDRGでは約100名の登録が達成されている。環境因子(allostatic load)の情報収集については、患者背景・臨床情報(腎機能、炎症、栄養状態、心不全、および動脈硬化指標等)に加えて、老化の表現系であるフレイルの評価項目に基づき、体組成分析・身体機能・身体活動量・精神状態に関するデータ収集を開始した。今後、社会因子としての経済指標や医療リテラシーに関する指標、介護度なども収集可能か検討している。
    循環白血球に取り込まれた細菌由来のDNA断片の解析については、NICE-GENEコホート研究における腸内細菌叢の変調の予備解析から、尿毒症などから惹起される酸性環境により炎症性の負担が増加することが一因で起こる腸内細菌叢の変調ではないかと推察した。 さらに、過去の報告と比較検討しこの腸内細菌叢の変調に推測される状況について、我々のコホートでの事例と合致するか検討を進める方針である。
    また、コントロールの検体収集として、おそらく約100名程度のサンプルが収集できる見込みである。
    国際共同研究施設であるカロリンスカ研究所、グラスゴー大学とは、COVID19パンデミック下、著しく交流が疎になっていたが、今後、国際学会などの機会を通じて情報交換を行い、循環白血球内のMicrobiomeの変調についてさらなる詳細な解析を行えるよう検討を継続していく。
    すでに開始してるコホート研究の患者登録については順調であるものの、循環白血球に取り込まれた細菌由来のDNA断片の解析については、すでに我々が予備解析に使用した健常人サンプルが、腎臓病患者サンプルと年齢構成があまりに異なり、検体数も少数であったため、比較検討がむずかしいことがわかった。そのため、新たに同年代の日本健常人の対照者によるサンプルの収集を開始している。
    腸内細菌叢の変調と細胞老年マーカーについて、テロメア長との検討を予定していた。しかしながら、共同研究者グラスゴー大学のProf. Paul Shielsより、我々が今まで行ってきたテロメア測定法によるテロメア長の解析よりCDKN2Aの評価のほうが、細胞老化を検討するにはSensitiveではないかとの指摘をいただき、予算やサンプルのクオリティも含めて実施可能か検討している。
    NICE-GENEコホート研究、RRTRコホート研究、N-KDRG研究いずれも、患者登録、サンプル収集、臨床情報収集を継続する。慢性腎臓病の初期の患者、さらに慢性腎臓病をきたしうる危険因子を持つ患者についても検討できると、慢性腎臓病の発症、進展、末期腎不全となってからの合併症にいたるまで、患者生涯をカバーするserialな経過を追うことができる。これが可能であれば、慢性腎臓病患者の老化を解明する当研究において研究目的を解明するために有用であると考えられる。
    また、循環白血球に取り込まれた細菌由来のDNA断片の解析については、細菌叢の変調は予想より多彩であった。細菌叢の変調の解釈についてすでに確立されたものが少なく、患者の表現系にどのように影響しているかについて報告するのに注意が必要であり、過去報告や共同研究機関でのデータとも比較し検討を続けていく。
    海外の研究者の興味は、日本人の慢性腎臓病患者の生存を含めた治療成績が欧米に比し良好であることが、日本食に起因しているのではないかというClinical Questionに基づいており、可能であれば食事に関する(とくに日本独特の発酵食品や魚介類の摂取)について追加情報を取得できないか検討していく方針である。

  5. ヒトiPS細胞由来間葉系幹細胞を用いた新規腎疾患治療法の開発

    Grant number:21K08253  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    田中 章仁, 石本 卓嗣, 丸山 彰一, 古橋 和拡

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    間葉系幹細胞(MSC)は様々な疾患に対する治療効果が示されている。しかし、MSCは品質のばらつきがあるため、治療効果の担保が大きな問題となっている。本課題では、iPS細胞からMSCを分化誘導し、腎炎に対する治療効果が安定して高いことを確認し、MSCの欠点を克服する。さらに治療効果を高める操作を加え、これまでのMSCよりも、腎炎に対して各段に高い治療効果を得る。最終的には、既存の治療法を凌駕する、難治性腎疾患に対する全く新しい細胞治療を確立する。

  6. 間葉系幹細胞の微小環境での炎症制御機構に着眼した次世代型免疫・炎症制御法の創成

    Grant number:21H04824  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(A)

    丸山 彰一, 古橋 和拡, 杉浦 悠毅, 平山 明由, 榎本 篤, 田中 章仁, 石本 卓嗣, 秋山 真一

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    Grant amount:\43030000 ( Direct Cost: \33100000 、 Indirect Cost:\9930000 )

    既存の免疫抑制薬は過剰免疫抑制による感染症などの副作用が問題となっている。間葉系幹細胞(MSC)は、障害部位の炎症強度に応じた自律的かつ局所での炎症制御が可能なことから、次世代の免疫制御療法として期待されている。しかし、その作用機序は十分解明されておらず、その実用化に際しては課題が多い。新概念として『障害部位に到達したMSC由来細胞外小胞が炎症細胞から放出される炎症性物質と微小空間で会合した時にのみ免疫抑制物質が生成されて局所での抗炎症作用が出現する』という着想に至った。本研究では、この新概念を検証して、効果的で安全な次世代型免疫・炎症制御療法の開発に取り組む。

  7. 日本の一次性膜性腎症における新規責任抗原の同定と臨床実態および病態機序の解明

    Grant number:21K08227  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    秋山 真一, 丸山 彰一

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    成人の一次性ネフローゼ症候群の主要な原疾患である一次性膜性腎症の診療では、近年、責任抗原に対する自己抗体を指標にした新しい診療技術が開発され、血液検査で鑑別診断および免疫的病勢評価が可能になりました。しかし、日本人の一次性膜性腎症患者の45%は責任抗原が未だ不明なため、自己抗体を指標にした新しい医療技術を受けられずにいます。
    そこで、本研究では、日本人一次性膜性腎症患者の未知の責任抗原を一つでも多く解明して、最終的には、日本人の一次性膜性腎症患者の大半で自己抗体を指標にした新しい診療技術が実現することを目差します。

  8. 特異的な間葉系幹細胞マーカーMeflinを介した腎線維化の機序解明と治療法の開発

    2020.4 - 2023.3

    科学研究費補助金  基盤研究(C)

    齋藤 尚二

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  9. 特異的な間葉系幹細胞マーカーMeflinを介した腎線維化の機序解明と治療法の開発

    Grant number:20K08589  2020.4 - 2023.3

    齋藤 尚二

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    1)Meflinの正常腎ならびに疾患モデルマウスにおける発現を正常マウスならびにMeflinノックアウトマウスを用いて解析する
    2)Meflin陽性細胞の腎線維化に関する役割をMeflin-CreERT2;Rosa26-LSL-tdtomatoマウスを用いて経時的・空間的に系譜追跡し解明する
    3)Meflin-ZsGreen-DTR-Creマウスを用いてMeflin陽性細胞を消去し、その役割を解明する
    4)Meflinの発現を誘導することにより、腎線維化進展や臓器不全の予防につながる治療法を開発する

  10. Renal plasma flow (RPF) and accurate GFR equations utilizing metabolomics analysis

    Grant number:20H03575  2020.4 - 2023.3

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  11. Screening of humoral pathogenesis of idiopathic focal segmental glomerulosclerosis by proteinuria visualized transparent model animal

    Grant number:19K22618  2019.6 - 2022.3

    Grant-in-Aid for Challenging Research (Exploratory)

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    Grant amount:\6500000 ( Direct Cost: \5000000 、 Indirect Cost:\1500000 )

  12. 慢性腎臓病患者における腸内細菌叢の変化とその改善による新規治療戦略の開発

    2019.4 - 2022.3

    科学研究費補助金  基盤研究(C)

    加藤 佐和子

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  13. 致死性血栓症における補体3型受容体の機能解明

    Grant number:19K07232  2019.4 - 2022.3

    水野 智博

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    活性化好中球が放出するヒストンにより惹起される線溶系有意の致死性血栓症は,凝固系有意の敗血症由来のものとは異なる。この致死性血栓症の発症メカニズムの解明研究は,凝固系有意の致死性血栓症治療薬とは作用機序の異なる新規治療薬開発の重要な基盤研究となる。本研究では,これまでの研究成果を踏まえ,新たに血小板凝集および組織への接着,白血球-血小板複合体に関与する補体3型受容体との関わりの重要性に着目し,Mac-1欠損およびPILRα欠損マウスへヒストンを投与して致死性血栓症モデル動物を作製し,Mac-1がヒストン誘発性致死性血栓症に関与するかどうか,を解明する。
    補体3型受容体(Mac-1:CD11b/CD18)は、血小板凝集および組織への接着や白血球-血小板複合体の生成促進に関与することが知られている。我々は、ヒストン誘導性致死性血栓症モデルマウスにおいて、白血球におけるMac-1発現が亢進することを確認しているが、出血と血栓形成の双方が関与する同疾患にて、Mac-1がどのように発症へ関与するのか、詳細は不明であった。致死性血栓症におけるMac-1の関与を明らかにするため、C57BL6/J(野生型)マウスおよび同系統のMac-1欠損マウスへ細胞外ヒストンを投与し、致死性血栓症モデル動物の作製を行った。ヒストン投与後の生存期間、肺、肝・腎障害の程度,プロトロンビン時間(PT)、活性化部分トロンボプラスチン時間(APTT)を評価および測定した。Mac-1欠損マウスでは、野生型マウスに比して、ヒストン投与後の生存期間が延長し、組織障害についても、軽度であった。PT、APTTについてはMac-1欠損および野生型マウス間で差が認められなかった。上記結果を踏まえ、Leukoladherin-1(LA-1)を用い、Mac-1を一時的に活性化させることで、上記遺伝子改変マウスと比較して、ヒストンによる反応性が異なるかどうかを検討した。野生型マウスにLA-1(LA-1群)およびコントロールとしてDMSO(コントロール群)を前投与し、その後ヒストンを投与することで致死性血栓症を惹起させたところ、LA-1群およびコントロール群間でヒストン投与後の生存期間、臓器障害に差は認められなかった。
    2019年度の研究実施計画は、C57BL6/J(野生型)マウスおよび同系統のMac-1欠損マウスへ細胞外ヒストンを投与し、ヒストン投与後の生存期間、肺、肝・腎障害の程度、プロトロンビン時間(PT)、活性化部分トロンボプラスチン時間(APTT)を評価および測定することであった。上記研究を完了し、次年度前半に予定していたLeukoladherin-1(LA-1)投与実験も完了することができた。以上の結果を踏まえ、当初の計画以上に進展していると考える。
    Leukoladherin-1(LA-1)前投与による致死性血栓症への影響が認められなかった要因として、ヒストン自身のMac-1活性化作用が考えられる。そのため、LA-1とは異なる方法を用い、好中球の関与を検討する必要がある。次年度は抗Ly-6G抗体を用い、好中球をdepleteさせることにより、ヒストンによる致死性血栓症に与える影響を検討する。さらに、野生型およびMac-1欠損マウスの両個体から好中球を単離し、ヒストンがNETosisへ与える影響についても、検討する。

  14. 補体活性と糖鎖異常に着目した二次性血栓性微小血管症(TMA)の病態解明

    Grant number:19K08692  2019.4 - 2022.3

    勝野 敬之

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    血栓性微小血管症(TMA)は腎予後、生命予後ともに不良な難治性病態であるが、早期診断法や治療法は確立されていない。申請者らは腎障害モデルにおいて、補体活性化が腎障害を増悪させることを見出してきた。近年、Glycocalyxによる血管内皮の恒常性維持作用が注目されている。本研究では、「二次性TMAでは糸球体内皮細胞上のGlycocalyxの発現が低下し、それにより補体活性化が惹起され腎障害が増悪する」という仮説を検証する。本研究を通して、TMAの早期診断や治療標的の同定につながる新たな知見を見出すことを最終目標とする。
    近年、血栓性微小血管症(thrombotic microangiopathy : TMA)と診断される症例は増加傾向にありその原因も多様である。
    わが国のTMAの実態を調査するため、日本腎臓学会による腎生検レジストリー(J-RBR)のデータを活用した横断研究を実施した。2007年から2017年の10年間で38,495例の腎生検症例が登録されており、そのなかでTMAと診断された症例は152症例(0.39%)であった。TMAの基礎疾患としては、溶血性尿毒症症候群(HUS)/血栓性血小板減少性紫斑病(TTP) 16.4%, 膠原病 17.1% 薬剤性16.4 %が多い結果であった。このほかにも臓器移植関連、高血圧、妊娠、悪性腫瘍などTMAの原因は多彩であった。疫学的には小児から高齢者まで幅広くTMAを発症していた。小児はHUS/TTPが有意に多いが、成人期以降では二次性TMAの頻度が増加する傾向が認められた。小児・成人・高齢者の比較では、高齢者で有意に腎機能が低下しており、糖尿病や高血圧などによる潜在的な内皮障害がTMA病態を促進させて可能性が示唆された。この結果はClin Exp Nephrol. 2020 May 15. doi: 10.1007/s10157-020-01896-7にて報告した。二次性TMAのなかでも頻度の高い膠原病関連TMAに関しては、抗リン脂質抗体症候群(antiphospholipid syndrome : APS)に着目し、APSにおける腎障害を報告した (J Clin Rheumatol. 2019 Nov 8. doi: 10.1097/RHU.0000000000001173)。
    現在は強皮症に関連したTMA病態である強皮症腎クリーゼの予後と治療効果に関する臨床研究を実施している。二次性TMAにおける補体活性系および制御系の関与については検体収集中であり、集まり次第C5b-9などの因子を測定していく予定である。二次性TMAの動物モデルの作成は確立しておらず進歩状況としてはやや遅れている。抗悪性腫瘍薬関連TMAに関してはレジストリーに該当する症例が予想を下回っており遅れが生じている。
    全身性強皮症を中心とした膠原病に関連したTMA病態の予後改善のため、臨床予後調査と治療効果に関する臨床研究を進める。薬剤性TMAに関しては、抗悪性腫瘍薬関連TMA発症の実態調査のため症例のレジストリーを進めていく。二次性TMAの動物モデルの作成についてはさらなる検討が必要である。

  15. 間葉系幹細胞治療における現在の問題点を解決する新たな細胞治療用カラムの開発

    Grant number:19K08722  2019.4 - 2022.3

    古橋 和拡

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    間葉系幹細胞(MSC)を用いた臨床試験はこの数年で著しく増加している。しかし、MSCを静脈内投与された患者が肺塞栓のため死亡した事例が報告されており、さらなる安全な幹細胞療法の開発が急務である。本研究では、MSCがもつ優れた成長因子・免疫制御因子の産生能力に着目し、細胞を直接体内に投与せず、これらの液性因子を体内に投与できる治療法としてMSC治療用中空糸膜カラムを開発する。これにより細胞による肺塞栓をゼロにできる。その際に、MSCの静脈内投与と遜色ない治療効果をカラムによって得るためには、MSCの活性化が必要であり、MSCを活性化する全く新しい細胞カラムを開発する。

  16. 難治性腎疾患におけるCaMK4を介した新規ポドサイト特異的治療法の開発

    Grant number:19K08723  2019.4 - 2022.3

    前田 佳哉輔

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    ポドサイトの機能不全は慢性腎臓病の進展に中心的な役割を担う。我々は、カルシウム/カルモジュリン依存性キナーゼIV(CaMK4)の活性化が、①ループス腎炎におけるポドサイト障害の原因の一つであること、②細胞骨格の制御を介したポドサイト障害と免疫複合体沈着・半月体形成に関与する知見を得た。
    また、本研究では難治性腎疾患(進行性半月体形成性腎炎、治療抵抗性ネフローゼ症候群)への治療応用を見据え、①ポドサイト内のCaMK4シグナルを介した半月体形成・糸球体硬化の分子機構の解明、②CaMK4をターゲットとした半月体形成性腎炎・難治性ネフローゼ症候群のポドサイト特異的新規治療法の開発をめざす。
    カルシウム/カルモヂュリン依存性キナーゼ(CaMK)シグナルに対するポドサイト特異的治療の確立のため、難治性腎疾患の一つである、難治性ネフローゼ症候群におけるCaMKシグナルの解析を行った。難治性ネフローゼ症候群の一つである巣状分節性糸球体硬化症(FSGS)においては、一部でCaMK4がポドサイト上に発現上昇が認められたが、CaMK2に関しては糸球体内での発現が見られなかった。同じカルシウム/カルモジュリン誘導性のキナーゼであるのにも関わらず、両者に違いが見られたことから、上流のCaMKキナーゼ(CaMKK)に着目した。なぜなら、CaMKKは、CaMKの中でCaMK1と4の活性化に必須のキナーゼで、CaMK2の活性化には関与しないためである。CaMKKは2種類のアイソフォームを持つが、両者を阻害する低分子化合物を使用して、その役割を検討した。FSGSモデルマウスに阻害薬を投与し、尿蛋白の推移を検討した。CaMK4阻害を行った場合と同様の結果が予想されたが、CaMKKの阻害により、蛋白尿の誘導に関しては有意な差は認められなかった。長期の経過では、野生型はある時点でピークを迎え尿蛋白は改善傾向に転じるが、阻害薬投与群においては改善の遅延がみられ、有意に障害が遷延する結果となった。CaMKKはポドサイト障害の可逆性に関与している可能性があり、今後CaMKKの2種類のアイソフォームの役割の違いも含めて、各々の遺伝子欠損マウスを使用し検証していく予定である。
    CaMKファミリーの発現の違いにより上流のCaMKKの調節機構の解析を要した。当初CaMK4を活性化する役割をもつCaMKKは、同様にポドサイト障害を軽減すると想定されたが、予想に反し悪化傾向を呈した。予定していたCaMK4の機能解析のみならず、上流のCaMKKの解析も行う必要があるため、やや遅れる結果となっている。
    今後は、CaMKK-CaMK4経路の解析のため、CaMKKのアイソフォーム毎の機能解析を行う。そのための各欠損マウスは取得済みである。

  17. 致死性血栓症における補体3型受容体の機能解明

    2019.4 - 2022.3

    科学研究費補助金  基盤研究(C)

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  18. 白血球・血管内皮細胞発現タンパクに着目した腎糸球体血管内皮障害特異的診断法開発

    2019.4 - 2022.3

    科学研究費補助金  基盤研究(C)

    坪井 直毅

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  19. 補体活性と糖鎖異常に着目した二次性血栓性微小血管症(TMA)の病態解明

    2019.4 - 2022.3

    科学研究費補助金  基盤研究(C)

    勝野 敬之

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  20. 間葉系幹細胞治療における現在の問題点を解決する新たな細胞治療用カラムの開発

    2019.4 - 2022.3

    科学研究費補助金  基盤研究(C)

    古橋 和拡

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  21. 難治性腎疾患におけるCaMK4を介した新規ポドサイト特異的治療法の開発

    2019.4 - 2022.3

    科学研究費補助金  基盤研究(C)

    前田 佳哉輔

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  22. マイクロRNAと脂肪幹細胞由来エクソソームを用いた、敗血症性AKI治療開発

    2019.4 - 2022.3

    科学研究費補助金  基盤研究(C)

    加藤 規利

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  23. Development of leukocytes and endothelial cell-derived biomarkers for glomerular endothelial injuries

    Grant number:19K08739  2019.4 - 2022.3

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  24. Changes of microbiome in patients with chronic kidney disease and new therapeutic strategy by their improvement

    Grant number:19K08700  2019.4 - 2022.3

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  25. マイクロRNAと脂肪幹細胞由来エクソソームを用いた、敗血症性AKI治療開発

    Grant number:19K08676  2019.4 - 2022.3

    加藤 規利

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    敗血症は、全世界的にみても死亡率が高い重篤な疾患である。また新たな治療法の開発は遅れ、生存率の改善は停滞している。我々はToll like receptorシグナルをmiRNAによって制御するといった、新しいアプローチによる治療を報告してきた。一方で幹細胞由来のエクソソームには、炎症性疾患における治療効果が報告されており、今回は低血清培地型脂肪由来幹細胞のエクソソームを用いて、我々が見つけ出したmiRNAを敗血症モデルマウスに投与して、治療効果の上乗せが可能かどうか、検証を行う。
    核酸医薬は、昨今開発が進む抗体医薬や細胞医薬に比して安価に安定的に生合成され、一度定めたプラットフォームを用いることによって、様々な疾患に応用可能な治療薬として注目を集めている。我々は、生体内に存在する自然のRNAi機構であるmicroRNA(miRNA)の治療的応用を目指し、過去においてPolyethylenimine (PEI)をドラッグデリバリーシステムとして用い、NF-κBを負に制御するmiR-146aを投与することで、敗血症モデルマウスの高サイトカイン血症を抑制し、生存率を高める事に成功してきた。
    一方細胞治療は、一部すでに実用化も進んでおり、様々な臨床的効果が期待されているが、核を含む細胞を体内に投与する事で、拒絶や癌化といったリスクが危惧されている。そこで細胞自身を投与するのではなく、細胞の放出する細胞外小胞、とくにエクソソームに着目し、エクソソームを投与することで細胞投与と同等の効果を認めたとする報告が多く見られるようになってきている。
    本研究は、当科で細胞治療研究として取り組んできた脂肪由来幹細胞(ASC)由来エクソソームを、それだけで投与するのではなく、治療効果をすでに確認しているmiRNAと組み合わせることで、治療の相乗効果を狙った新しい治療プラットホームの開発を目的としている。
    動物実験の解析により、投与したmiR-146a 発現プラスミドの作用点は脾臓であることが判明している。本年度においては、先行研究で用いたmiR-146a発現プラスミドは生体応用し難いため、成熟miRNAおよび人工核酸においても同等に脾臓がターゲットとして治療効果を得られるかを中心に検証すべく研究を行った。
    脾臓は二次リンパ節としては最大で、敗血症の発症において抗原提示、免疫の増幅、全身性へのサイトカイン産生の主たる臓器として役割を持っている。先行研究においてはmiR-146a発現プラスミドを用いており、発現に時間がかかるとともに生体の核内に遺伝子が導入されてしまうことになるため、一過性発現かつ即効性のある成熟miRNAを用いて、脾臓での取り込みを確認した。
    まず成熟miRNAを、PEIをドラッグデリバリーシステムとして脾臓への直接注射を行い、脾臓に投与後24時間をピークに48時間まで検出可能であることを確認した。脾臓に直接投与した場合、ごく一部合流した門脈を介して肝臓においても検出されたが、腎臓、肺には影響を及ぼさなかったため、他臓器への影響は限局的であることが示唆された。また同様に先行研究で明らかになったmiR-146aの脾臓マクロファージへの取り込みに関しても、F4/80による脾臓細胞のセレクションにより証明した。
    次に盲腸結紮穿孔モデルによりマウスに敗血症を起こし、同様にmiR-146aを投与した所、対照群(スクランブル配列)と比較して、Cr, BUN, AST, ALT, LDHを低下させることが可能であった。ただし、死亡率はmiR-146a投与群でむしろ悪化しており、治療により死亡を増やすが、生存した群においては治療効果を示すという結果となった。
    さらによりエクソソームに近いと考えられる、リポソームをドラッグデリバリーシステムとして用いた治療実験において、現時点で治療効果は確認できていない。
    マウス盲腸結紮穿孔モデルに置いて、miR-146a脾臓注射が治療効果を示す一方で死亡率を高めた理由の考察として、miR-146aが脾臓のマクロファージに取り込まれるところは確認されており、そのNF-κB抑制作用によりサイトカイン産生を抑制することから、(1)腹腔内の感染、菌血症に対する炎症の初期反応が抑制されてしまった可能性、(2)より晩期の免疫抑制によりsecondary infectionを引き起こした可能性の両面が考えられる。
    そもそも先行研究において効果が見られた原因としては、敗血症晩期の過剰な免疫反応としてのサイトカインストームを抑制するところにあり、感染成立初期の特に自然免疫の反応を抑制してしまった場合は最近の増殖を抑えきれず、そのまま死に至ると考えられるし、晩期の免疫力が正常に戻った後過剰な免疫抑制を起こした際は、二次感染で死亡する。つまり投与するタイミングが非常に重要であり、我々の先行研究においては、敗血症を起こす前に事前投与していたが、miR-146a発現プラスミドであったことから、効果の発現に時間がかかり、時期としてちょうど首尾よくサイトカインストームを抑制した可能性がある。
    臨床応用に関しては、事前投与は困難であることから、今後は(1)の可能性を考慮して、敗血症モデル作成直後に投与すするのではなく、数時間空けて投与することで反応を確認していく予定である。
    また、投与方法として脾臓直接注射は多臓器への影響が少なくより選択的に治療対象とする脾臓マクロファージに取り込まれるが、生体に与える侵襲も高い。よって今後は静注、腹腔内投与と言った別経路による治療を検討し、条件を確定していく予定である。

  26. 蛋白尿可視化透明モデル動物による特発性巣状分節性糸球体硬化症の液性病因の解明

    2019.4 - 2021.3

    科学研究費補助金  研究成果公開促進費 (研究成果公開発表)

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  27. 日本の一次性膜性腎症における責任抗原ごとの病態理解と新規診断法の確立

    2019.4 - 2021

    科学研究費補助金  基盤研究(C)

    秋山 真一

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  28. 糖尿病性腎臓病における2つのフルクトース代謝酵素の役割の解明とその治療応用

    2018.4 - 2021.3

    科学研究費補助金  基盤研究(C)

    石本 卓嗣

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  29. 臨床応用を指向した腎疾患病型スクリーニング法の開発

    2018.4 - 2021.3

    科学研究費補助金  基盤研究(C)

    平山 明由

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  30. 臨床応用を指向した腎疾患病型スクリーニング法の開発

    Grant number:18K08219  2018.4 - 2021.3

    平山 明由

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    本年度は、前年度に同定したループス腎炎のバイオマーカー候補について、液体クロマトグラフィー―質量分析計を用いた高速分析法の開発を行った。これにより、従来キャピラリー電気泳動―質量分析計を用いて30分かかっていた測定時間を約10分に短縮することが可能になった。
    また、バイオマーカー候補については異なる時期に採取されたバリデーション用検体を用いて、マーカーとしての感度・特異性の検討を実施した。7つの異なるネフローゼ疾患患者尿120検体を用いてバリデーション試験を実施した結果、独立した検体群においてもループス腎炎を他の6種のネフローゼから高精度に判別できることが証明された。
    また、検体の臨床情報との相関についても検討を実施した。検体のベースラインデータとの相関を検討した所、BMIと体重には弱い相関がみられたが、その他は相関が見られなかった。さらに、ループス腎炎に関しては病理型との関連も検討したが、顕著な関連は見られなかった。本マーカーは、濃度が低い方が完全寛解が遅く、腎機能悪化も多い傾向が見られ、濃度の高い方が予後が良い傾向が認められた。
    さらに、ループス腎炎患者血漿中のマーカー濃度についても検討を行った。10名のループス腎炎患者の血漿中のマーカー濃度を健常者と比較した所、尿同様に患者血症中でも高い傾向が認められた。
    マーカー代謝物の化学合成に少し時間を要しているが、おおむね計画通り進んでいる。
    共同研究先への結果のフィードバックを速やかに行い、必要に応じて追加検体を受け取れる体制を整えていく。

  31. 日本の一次性膜性腎症における責任抗原ごとの病態理解と新規診断法の確立

    Grant number:18K08239  2018.4 - 2021.3

    秋山 真一

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    本研究では、膜性腎症の中でも責任抗原が不明な特発性膜性腎症について未知の責任抗原の解明を目指すと共に、Phospholipase A2 receptor(PLA2R)やThrombospondin 7A(THSD7A)を含む各責任抗原に対する自己抗体を指標にした病態理解および新規診断法の開発に取り組んでいる。
    研究2年目の進捗は以下の通りである。未知の責任抗原の同定では、研究1年目に開発した患者血清を用いた免疫沈降法を用いて抗原検索を継続した。また、昨年度の実験で得られた新規抗原候補となるタンパク質の同定作業にも取り組んだ。質量分析により得られた新規抗原候補群からポドサイトに発現する膜タンパク質を抽出して、各候補抗原のcDNA断片を組み込んだ発現ベクターを作成し、各種組換えタンパク質を取得した。得られた抗原タンパク質を用いて患者血清に対する結合試験を開始した。一方、既知責任抗原であるPLA2Rのエピトープ解析では、海外の先行論文にて一次性膜性腎症患者がもつ自己抗体のエピトープとして報告されているシステインリッチドメイン(CysR)、Cタイプレクチンドメイン1番(CTLD1)、Cタイプレクチンドメイン5番(CTLD5)、Cタイプレクチンドメイン7番(CTLD7)、Cタイプレクチンドメイン8番(CTLD8)に対するエピトープ分布解析に取り組んだ。各ドメインの組換えタンパク質を調製して、抗PLA2R陽性一次性膜性腎症患者の診断時血清を用いて解析を実施した。その結果、日本人患者ではエピトープ分布と病勢・予後との間に海外症例で報告されたような明瞭な相関は認められず、日本人患者では診断時の抗PLA2R抗体濃度の方がより予後との相関が強いことが示された。
    未知抗原の同定では候補抗原の発現と患者自己抗体に対する結合性確認を繰り返す作業に移行できている。自己抗体濃度やエピトープ分布による病勢・予後解析では計画通りに推進できてデータの蓄積が進んでいる。
    順調に進展しているため今後も当初の研究計画に沿って進める。具体的には、未知抗原同定とPLA2R関連膜性腎症患者およびTHSD7A関連膜性腎症患者の血清を用いた自己抗体濃度およびエピトープ分布による病勢・予後診断法の検討を進める。

  32. The roles of two isoforms of fructokinase on diabetic kidney disease

    Grant number:18K08238  2018.4 - 2021.3

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  33. 間葉系幹細胞特異的マーカーを利用した糸球体腎炎の病態解明と新規細胞治療法の開発

    2017.4 - 2020.3

    科学研究費補助金  基盤研究(B)

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  34. Analysis of the role of mesenchymal stem cell marker Meflin in kidney fibrosis

    Grant number:17K09696  2017.4 - 2020.3

    Saito Shoji

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    Fibrosis is a key regulator of organ damage.myofibroblast is essential for rise of fibrosis, and it is said that MSC is one of the origin. We previously report that a cell surface and secreted protein, Meflin, is expressed in cultured MSCs, fibroblasts and pericytes, but not other types of cells including epithelial, endothelial and smooth muscle cells. We also found Meflin is a potential marker for cultured MSCs and focused on the mechanism of fibrosis by investigating Meflin.
    We discovered that Meflin expresses in intersititum and around the vascular pole of glomerulus. And its’ expression increases when glomerular inflammation and fibrosis progresses.We also investigated the manner of Meflin positive cells with Meflin reporter mice generated in our lab.
    In vitro study also suggested that Meflin is positively regulating kidney fibrosis.

  35. Analysis of the role of mesenchymal stem cell marker Meflin in glomerulonephritis

    Grant number:17H04186  2017.4 - 2020.3

    maruyama shoichi

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    Grant amount:\16900000 ( Direct Cost: \13000000 、 Indirect Cost:\3900000 )

    We previously report that a cell surface and secreted protein, Meflin, is expressed in cultured MSCs, fibroblasts and pericytes, but not other types of cells including epithelial, endothelial and smooth muscle cells. We also found Meflin is a potential marker for cultured MSCs and focused on manner of Meflin with the onset of glomerulonephritis.
    We discovered that Meflin express in intersititum and around the vascular pole of glomerulus. And its’ expression increases when glomerular inflammation and fibrosis progresses.
    We also investigated the manner of Meflin positive cells with Meflin reporter mice generated in our lab.

  36. 間葉系幹細胞に着目した腎間質線維化の機序解明と新規治療法の開発

    2017.4 - 2020.3

    科学研究費補助金  基盤研究(C)

    齋藤 尚二

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  37. International Study for Development and Clinical Aplication of Lupus Biomarkers Reflecting Renal Inflammation

    Grant number:17H04667  2017.4 - 2020.3

    Tsuboi Naotake

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    Because kidney biopsy essential for diagnosis is associated with risk of bleeding and requires hospitalization of patients, repeated examinations for the evaluation of therapeutic efficacy and disease recurrence are not encouraged.
    We hypothesized that surface molecules on inflammatory glomerular leukocytes leak into urine. Accordingly, we analyzed bio-samples from domestic and international patients with kidney diseases. The study revealed significant elevation of urinary CD11b with increased numbers of glomerular leukocytes expressing CD11b in patients with lupus nephritis, a major kidney complication of systemic lupus erhythematosus, and in patients with vasculitis. Further analysis of the diagnostic performance for predicting active lupus nephritis demonstrated marked superiority of urinary CD11b compared with two other leukocyte-derived molecules (CD163 and CD16b).

  38. Elucidation of intracellular import and metabolic circuits involving CD147/Basigin and development of novel therapeutics through regulation of sugar chain modification

    Grant number:17K09695  2017.4 - 2020.3

    Kosugi Tomoki

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    In the present study, we aimed to elucidate the underlying mechanisms of chronic kidney disease (CKD) and hepatic steatosis caused by nutritional overburden more in details. Therefore, we investigated the role of CD147/Basigin (BSG) to maintain intracellular energy homeostasis, using high fat diet (HFD)-induced wild-type and BSG gene-deficient (BSGKO) mice. In the kidneys of BSGKO mice, vacuolar degeneration of tubular epithelial cells and accumulation of lipofuscin-like substances were remarkably suppressed. These findings might be due to the phenomena that transport of the substrates such as pyruvate and lactate in the cells was suppressed by BSG deficits subsequently leading to the the reduction of TCA cycle intermediates and enhanced ketogenesis through activation of free fatty acid beta oxidation. In the setting, augmented BSG protein might be due to the promotion of autophagy, but not translocation to nuclei.

  39. 血管内皮障害を呈する腎疾患におけるSulf2の機能解析と新たな治療戦略の探求

    2017.4 - 2019.3

    科学研究費補助金  基盤研究(C)

    増田 智広

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  40. 血管内皮障害を呈する腎疾患におけるSulf2の機能解析と新たな治療戦略の探求

    Grant number:17K09694  2017.4 - 2019.3

    増田 智広

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    細胞外スルファターゼSulf2は、分子量約130kDaの分泌型酵素で細胞外での膜タンパクに付着している糖鎖の脱硫酸化を担いWnt, BMP, GDNF, FGFというヘパリン結合性因子のシグナル伝達を制御する物質である。
    腎臓領域ではSulf1およびSulf2が細胞外基質蓄積を制御し糖尿病性腎症悪化に寄与するとの既報がある。また、ヘパラン硫酸-S-ドメインの蓄積は原線維形成を促進し、腎臓での細胞毒性を促進するという知見が加わった。上記よりSulf2Tgは腎保護に寄与すると仮説を立て私はヒトSulf2全身強制発現マウス(HSulf2Tg)と血管内皮細胞特異的Sulf2強発現 (Tie2-Cre/Sulf2)を用いて、腎機能にどのように関与するか機序解明を目指した。
    初年度の計画としてはHSulf2Tgの腎障害惹起時に表現型の確認。腎障害を惹起していない野生型とHSulf2Tgを比較し双方ともに腎機能が正常であった。また、腎障害モデルとして交付申請書に記載した抗基底膜抗体により直接的に糸球体内皮細胞を障害する加速型馬杉腎炎モデルに加えて、アドリアマイシン腎症モデル、糖尿病モデルを作成。いずれのモデルにおいても、HSulf2Tgの方が 尿素窒素・クレアチニン・尿タンパクが低値であった。しかし、Tie2-Cre/Sulf2は野生型と比して尿素窒素・クレアチニン・尿タンパクのいずれも差異は認めなかった。

  41. CD147による細胞内輸送・代謝機構の解明と糖鎖修飾調整を介した新規治療法の開発

    2017.3 - 2020.3

    科学研究費補助金  基盤研究(C)

    小杉 智規

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  42. ExosomesとマイクロRNAを用いた、安全性の高いオーダーメイド治療の開発

    2016.4 - 2019.3

    科学研究費補助金  基盤研究(C)

    加藤 規利

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  43. 白血球接着因子とその調節分子の糸球体腎炎における機能解析と細胞移入治療への応用

    2016.4 - 2019.3

    科学研究費補助金  基盤研究(C)

    坪井 直毅

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  44. Introduction of preventive and preemptive medicine against chronic antibody-mediated rejection for long-term graft survival

    Grant number:16H05465  2016.4 - 2019.3

    KOBAYASHI TAKAAKi

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    Chronic antibody-mediated rejection is one of major obstacles to long-term graft outcome after kidney transplantation. We focused on preventive or preemptive medicine for de novo DSA production, because anti-rejection treatment has proved ineffective after manifestation of renal dysfunction. CD8+ T cell and B cell-targeting drug sensitivity test could be established. The expression level of CD40L on T cell would be a promising biomarker for antibody production. Potential value of miRNA (142-3p, 1913, 374-5p), mRNA (CIITA, CTLA-4) and donor-derived cell free DNA for preemptive treatment was elucidated. Graft accommodation induced by ABO incompatibility was elicited by up-regulation of CD55/59 and down-regulation of HLA class II through ERK inactivation and mTOR inactivation, respectively. Establishment of T cell indirect recognition assay, analysis of T cell receptor (TCR), and the feasibility of drug-induced graft accommodation should be next challenging subjects.

  45. Functional analyses of leukocyte integrins and its regulatory molecule in glomerulonephritis and those application for cell transfer therapy

    Grant number:16K09611  2016.4 - 2019.3

    Tsuboi Naotake

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    【Background】PILRα expressed on leukocytes has regulatory functions in leukocyte β2 integrin activation during acute inflammation. Here, we investigated its roles in antibody-mediated glomerular inflammation.【Results】PILRα-/- mice with NTS-GN demonstrated severe glomerular injury. Enhanced glomerular neutrophil accumulation was observed in NTS-GN PILRα-/- only under pre-immunized conditions. PILRα-/- neutrophils exhibited enhanced spreading and adhesion to ICs compared to those in WT cells.【Conclusion】PILRα negatively regulates antibody-mediated neutrophil recruitment, leading to renal injury, by inhibiting Mac-1 integrin activation.

  46. Research on diagnosis, treatment and epidemiology of membrane nephropathy in the Asia-Pacific region

    Grant number:16H05839  2016.4 - 2019.3

    maruyama Shoichi

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    Grant amount:\17940000 ( Direct Cost: \13800000 、 Indirect Cost:\4140000 )

    In order to standardize treatment for membranous nephropathy (MN), we investigated the current status of diagnosis, treatment, and epidemiology of the MN in countries of Asia and the Pacific region including Japan. The medical treatment and patient registration system of MN were very different depending on the country. The prevalence of anti-PLA2R antibody in primary MN patients was reconfirmed in Japan as low as about 50%. On the other hand, the prevalence of PLA2R antibodies in patients in China, Taiwan and Korea were all 80%, equivalent to patients in Western countries. On the contrary, the prevalence of THSD7A antibody was slightly higher in Japan than in other countries. In countries where measurement of autoantibodies cannot be performed, it was concluded that pathological staining of antigens would be the first choice. This study was able to collect a lot of information for the standardization and diffusion of future MN medical care.

  47. Investigation of safer methods of therapeutic miRNA and exosomes

    Grant number:16K09610  2016.4 - 2019.3

    Kato Noritoshi

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    We investigated the pathophysiological role of exogenously applied microRNA (miRNA) in sepsis-induced multiple organ injury. In vitro, we tested possible miRNAs which suppressed the production of pro-inflammatory cytokines. Of these, miR-146a displayed the highest suppressive effect. Sepsis was induced in mice via cecal ligation and puncture (CLP) and an intravenous injection of a complex of miR-146a-expressing plasmid and polyethyleneimine. Treatment with this complex significantly decreased the level of serum inflammatory cytokines, attenuated organ injury, and led to increased survival from sepsis. miR-146a-expressing plasmid was abundantly distributed in splenic macrophages. CLP mice treated with miR-146a displayed significantly decreased NF-κB activation in the spleen. The collective results support the conclusion that the induction of miR-146a expression in splenic macrophages prevents excessive inflammation and sepsis-induced multiple organ injury.

  48. Development of novel antihypertensive therapy with tissue protection in renal and cardiovascular diseases through elucidation of MK-EETs blood pressure regulation mechanism

    Grant number:16K09609  2016.4 - 2019.3

    Kato sawako

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    In a system aiming at deep observation of the living body using multiphoton confocal laser microscope A1R MP (Nikon), administration of epoxy eicosatrienoic acids (EETs) inhibitor and adenosine inhibitor, induced the vasoconstrictive action in Midkine (MK) deficient mice. The blood vessels were contracted and blood flow was decreased, as blood pressure increased. The blood flow rate was rising. On the other hand, when a nicotinic acetylcholine receptor inhibitor was administered to evaluate the sympathetic nervous system, blood pressure dropped in MK deficient mice, indicating an increase in blood flow. MK has been shown to regulate renal and blood pressure via a vasodilator.

  49. RCTを用いたイコサペンタ酸(EPA)による腎保護戦略の確立と作用機序の解明

    2016.4 - 2018.3

    科学研究費補助金  基盤研究(B)

    小林 孝彰

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  50. Drug discovery of orphan drug for congenital kidney disease using kidney visualization transparent model animal

    Grant number:16K15468  2016.4 - 2018.3

    MARUYAMA Shoichi

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    Grant amount:\3510000 ( Direct Cost: \2700000 、 Indirect Cost:\810000 )

    We aimed to develop a novel drug discovery platform for medicine for congenital renal disease which was based on in vivo phenotype screening using kidney-visualized-transparent-zebrafish.
    As a result, we bred a new line of transparent zebrafish that is more growth efficiency and more transparency than conventional lines. Although, the gene editing-based congenital nephrotic syndrome model lines could not be generated during study period, the congenital whole-body calcification model transparent kidney visualized line was generated using a phosphorus transporter mutant line. As a result of a compound administration experiment using frying fish, it was possible to observe dose-dependent occurrence of edema, kidney malformation, disappearance of nephron, etc. according to the nephrotoxicity of the compound. These data demonstrated the feasibility of in vivo screening system using kidney visualized transparent zebrafish.

  51. アジア太平洋地域における膜性腎症の診断・治療・疫学に関する調査研究

    2016.4 - 2017.3

    科学研究費補助金  基盤研究(B)

    丸山 彰一

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  52. 腎臓可視化透明モデル動物を用いた先天性腎疾患に対するオーファンドラッグの創薬

    2016.4 - 2017.3

    科学研究費補助金  挑戦的萌芽研究

    丸山 彰一

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  53. Treatment for kidney disease using fetal membrane-derived mesenchymal stem cells.

    Grant number:15K09256  2015.4 - 2019.3

    Katsuno Takayuki

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    Applicants' previous studies have identified mesenchymal stem cells (MSC) differentiation under conditions where the serum concentration of the culture solution of fetal membrane-derived MSC (FM-MSC) was changed to 2%. However, in the low serum culture method with a serum concentration of 2%, the proliferation ability of the FN-MSCs was attenuated, and the proliferation rate was decreased in passage3. When hFGF (human fibroblast growth factor) was added for the purpose of promoting the growth of MSCs and the culture medium was introduced, an improvement in the growth rate was obtained but the problem that the undifferentiated state was not maintained became clear. The FM- MSC could not give the same result as that of adipose tissue-derived MSC. This study suggested that low serum culture may be dependent on cell source.

  54. Study on the clinical and pathological features of PLA2R-related membranous nephropathy in Japan

    Grant number:15K09257  2015.4 - 2019.3

    Akiyama Shin'ichi

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    We studied on the clinical reality and pathophysiology of PLA2R-associated membranous nephropathy, a new concept of primary membranous nephropathy, in Japanese patients. We optimized the method of measuring PLA2R antibody according to the clinical situation of Japanese patients. The PLA2R antibody measurement at the time of renal biopsy was shown not only useful for differentiation of PLA2R-related membranous nephropathy but also useful for predicting prognosis. PLA2R antibody-positive patients who have a history of smoking have been shown to delay complete remission. Patients with a PLA2R antibody concentration of 50 RU/ml or more at the time of renal biopsy were shown to have a significantly worse renal prognosis.

  55. 慢性腎臓病・高血圧におけるフルクトース代謝の役割と分子機構の解明

    2015.4 - 2018.3

    科学研究費補助金  基盤研究(C)

    石本 卓嗣

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  56. 日本における抗PLA2R抗体関連膜性腎症の実態と病態機序の解明

    2015.4 - 2018.3

    科学研究費補助金  基盤研究(C)

    秋山 真一

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  57. 腎領域の臨床研究を改善する新規腎アウトカム指標を決定する国際共同研究

    2015.4 - 2018.3

    科学研究費補助金  基盤研究(B)

    安田 宜成

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  58. 卵膜由来間葉系幹細胞を用いた腎疾患治療

    2015.4 - 2018.3

    科学研究費補助金  基盤研究(C)

    勝野 敬之

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  59. International Collaborative Sutudy for Surrogate Renal Outcomes in Clinical Research

    Grant number:15H05291  2015.4 - 2018.3

    Yasuda Yoshinari

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    In Asian collaborative study, we analyzed suitable surrogate renal outcomes for clinical research. First, we established accurate renal function evaluation methods for Korean, Taiwan ,Thai and Indian CKD patients. Second, we analyzed utility of various renal outcomes in Asia. In health-check subject and CKD cohort studies, 30% decrease in eGFR could be surrogate renal outcome instead of hard end point including end stage kidney disease. Among IgA nephropathy patients, 50% increase in serum creatinine was good renal outcome to assess treatment effect and prognosis in renal biopsy. By surveillance of Asian renal outcome studies, GFR decline rate was sensitive and reliable renal outcome.

  60. The role of fructose metabolism in the development of chronic kidney disease and hypertension.

    Grant number:15K09255  2015.4 - 2018.3

    ISHIMOTO TAKUJI

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    The aim of this study is to elucidate the role of fructose metabolism by the primary enzyme of fructose, ketohexokinase (KHK) in hypertension. In this study, by using KHK knockout mice (KHK-KO), we found that the combination of fructose and high salt induced the elevation of blood pressure with decrease of sodium excretion and increase of mRNA expression of NHE3 in kidney in wild type mice (WT), but not in KHK-KO mice, and that fructose stimulation increased NHE activity accompanied by a decrease in intracellular cAMP that is dependent on KHK. These results suggest that fructose metabolism by KHK is involved in the development of salt-sensitive hypertension through increases of renal sodium reabsorption by NHE3.

  61. CD147による腎エネルギー代謝機構の解明と臓器相関に対する治療法の探究

    2014.3 - 2017.3

    科学研究費補助金  基盤研究(C)

    小杉 智規

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  62. 慢性腎臓病患者におけるテロメア消耗と環境因子の国際比較

    2014.3 - 2015.3

    科学研究費補助金  基盤研究(B)

  63. 脂肪由来幹細胞の免疫抑制作用の解明と高機能化

    2013.4 - 2016.4

    科学研究費補助金  基盤研究(C)

    丸山 彰一

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  64. アジア太平洋地域における膜性腎症の実態調査研究

    2013.4 - 2016.4

    科学研究費補助金  基盤研究(B)

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  65. 進行性腎障害における免疫調整性マクロファージの機能解析と細胞移入治療効果の検討

    2013.4 - 2016.3

    科学研究費補助金  基盤研究(C)

    坪井 直毅

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  66. 腎移植における慢性抗体関連型拒絶反応制御のための総合的戦略

    2013.4 - 2016.3

    科学研究費補助金  基盤研究(B)

    小林 孝彰

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  67. メタボローム解析を用いた腎疾患における新規診断法の開発

    2013.4 - 2016.3

    科学研究費補助金  特別推進研究

    尾崎 武徳

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  68. 慢性腎臓病患者における慢性炎症惹起の解明と制御性T細胞を用いた新規治療戦略

    2013.4 - 2016.3

    科学研究費補助金  基盤研究(C)

    加藤 佐和子

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  69. ミッドカインによる内皮細胞由来の血管作動因子を介した血圧調整のメカニズムの解明

    2013.4 - 2015.3

    科学研究費補助金  基盤研究(B)

    松尾 清一

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  70. アジア系人種における糖尿病性腎症の予後調査と予後規定因子の国際比較研究

    2012.9 - 2014.3

    科学研究費補助金  基盤研究(B)

    和田 隆志

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  71. プラズマ医療科学の臨床応用論的学術基盤の構築と体系化

    2012.4 - 2017.3

    科学研究費補助金 

    吉川 史隆

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  72. 腎移植時合併症の新規「早期診断・鑑別診断」バイオマーカーの開発

    2012.4 - 2015.3

    科学研究費補助金  基盤研究(C)

    湯澤 由紀夫

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  73. 免疫学的劇症肝炎モデルマウスにおける新たな細胞治療の基礎的検討

    2012.4 - 2015.3

    科学研究費補助金  基盤研究(C)

    石上 雅敏

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    Authorship:Coinvestigator(s) 

  74. アジア腎生検レジストリーの創設と最適な腎疾患治療を目指すアジア腎疾患コホート研究

    2012.4 - 2015.3

    科学研究費補助金  基盤研究(B)

    安田 宜成

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    Authorship:Coinvestigator(s) 

  75. 慢性腎不全の生命予後を規定する遺伝子情報の国際比較調査研究

    2011.4 - 2014.3

    科学研究費補助金  基盤研究(B)

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    Authorship:Coinvestigator(s) 

  76. 慢性腎臓病におけるCD147の機能解析と新たなCKD治療戦略の確立

    2011.4 - 2014.3

    科学研究費補助金  基盤研究(C)

    小杉 智規

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    Authorship:Coinvestigator(s) 

  77. 新規脂肪由来間葉系幹細胞における免疫制御分子機構の解明

    2011.4 - 2013.3

    科学研究費補助金 

    松尾 清一

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    Authorship:Coinvestigator(s) 

  78. 脂肪由来間葉系幹細胞を用いた免疫抑制療法の開発

    2010.4 - 2013.3

    科学研究費補助金  基盤研究(C)

    尾崎 武徳

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    Authorship:Coinvestigator(s) 

  79. 患者血清を用いた免疫複合体疾患動物実験モデルの樹立

    2010.4 - 2013.3

    科学研究費補助金  基盤研究(C)

    坪井 直毅

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    Authorship:Coinvestigator(s) 

  80. 新たな疾患概念「腎障害におけるRASを介した腎・肺連関」の確立

    2010.4 - 2013.3

    科学研究費補助金  基盤研究(C)

    佐藤 和一

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    Authorship:Coinvestigator(s) 

  81. 脂肪由来細胞を用いた腎疾患治療の開発 ―再生促進作用と免疫抑制作用の融合―

    2009.4 - 2012.3

    科学研究費補助金  基盤研究(C)

    丸山 彰一

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    Authorship:Principal investigator 

  82. 拒絶反応と免疫順応・寛容に関与する抗原、抗体、補体、炎症、凝固のダイナミズム解析

    2008.4 - 2011.3

    科学研究費補助金  基盤研究(B)

    小林 孝彰

  83. 脂肪細胞を用いた腎再生医療の新展開

    2007.4 - 2009.3

    科学研究費補助金  基盤研究(C)

    丸山 彰一

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    Authorship:Principal investigator 

  84. 尿細管間質障害の新たなバイオマーカー及び治療標的としてのミッドカインの基礎的研究

    2006.4 - 2008.3

    科学研究費補助金  基盤研究(B)

    松尾清一

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    Authorship:Coinvestigator(s) 

  85. ABO血液型バリア克服のためのグラフト脱抗原化と免疫順応誘導

    2006.4 - 2007.3

    科学研究費補助金  基盤研究(C)

    小林 孝彰

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    Authorship:Coinvestigator(s) 

  86. 腎臓の発生と再生における新規遺伝子GZF1の役割における研究

    2004.4 - 2006.3

    科学研究費補助金 

    松尾清一

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    Authorship:Coinvestigator(s) 

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Teaching Experience (On-campus) 4

  1. Vasculitis

    2021

  2. Nephrology

    2021

  3. Nephrology

    2021

  4. Nephrology

    2021

Teaching Experience (Off-campus) 1

  1. Nephrology

    2016.6 Meijo University)

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    Level:Undergraduate (specialized)