Faculty Profiles - IWANO, Shingo

Papers - IWANO, Shingo

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Imaging endolymphatic hydrops at 3 tesla using 3D-FLAIR with intratympanic Gd-DTPA administration.

Naganawa, Shinji; Satake, Hiroko; Iwano, Shingo; Fukatsu, Hiroshi; Sone, Michihiko; Nakashima, Tsutomu

Magn Reson Med Sci Vol. 7 page： 85-91 2008

Solitary fibrous tumor of the pleura: evaluation of the origin with 3D CT angiography. Reviewed

Usami N, Iwano S, Yokoi K.

J Thorac Oncol. Vol. 2 ( 12 ) page： 1124-5. 2007.12

類似CT画像検索CADの試み

岩野信吾, 岡田徹, 神岡祐子, 石垣武男, 長縄慎二

映像情報Medical Vol. 39 ( 13 ) page： 1215-19 2007.12

Usefulness of dynamic computed tomography for the diagnosis of mediastinal hemangioma. Reviewed

Okasaka T, Iwano S, Usami N, Uchiyama M, Sato N, Yokoi K.

Vol. 60 ( 11 ) page： 1031-4 2007.10

Comparison of 18F-FDG PET and Bone Scintigraphy in Detection of Bone Metastases of Thyroid Cancer.

Ito S, Kato K, Ikeda M, Iwano S, Makino N, Tadokoro M, Abe S, Nakano S, Nishino M, Ishigaki T, Naganawa S

J Nucl Med Vol. 48 page： 889-895 2007

Language：English Publishing type：Research paper (scientific journal)

We compared the efficacies of (18)F-FDG PET and (99m)Tc-bone scintigraphy for the detection of bone metastases in patients with differentiated thyroid carcinoma (DTC). METHODS: We examined 47 patients (32 women, 15 men; mean age +/- SD, 57.0 +/- 10.7 y) with DTC who had undergone total thyroidectomy and were hospitalized to be given (131)I therapy. All patients underwent both whole-body (18)F-FDG PET and (99m)Tc-bone scintigraphy. The skeletal system was classified into 11 anatomic segments and assessed for the presence of bone metastases. Bone metastases were verified either when positive findings were obtained on >2 imaging modalities-(201)Tl scintigraphy, (131)I scintigraphy, and CT-or when MRI findings were positive if vertebral MRI was performed. RESULTS: Bone metastases were confirmed in 59 of 517 (11%) segments in 18 (38%) of the 47 study patients. The sensitivities (visualization rate) for bone metastases on a segment basis using (18)F-FDG PET and (99m)Tc-bone scintigraphy were 50 of 59 (84.7%) and 46 of 59 (78.0%), respectively; the difference between these values was not statistically significant. There were only 2 (0.4%) false-positive cases in a total of 451 bone segments without bone metastases when examined by (18)F-FDG PET, whereas 39 (8.6%) were false-positive when examined by (99m)Tc-bone scintigraphy. Therefore, the specificities of (18)F-FDG PET and (99m)Tc-bone scintigraphy were 449 of 451 (99.6%) and 412 of 451 (91.4%), respectively; the difference between these values was statistically significant (P < 0.001). The overall accuracies of (18)F-FDG PET and (99m)Tc-bone scintigraphy were 499 of 510 (97.8%) and 458 of 510 (89.8%), respectively; the difference between these was also statistically significant (P patients has recently improved. In particular, patients with good PS showed better local control than those with poor PS. However, we could not identify any significant prognostic factors in PCNSL patients.

【膵疾患の画像診断最近のトレンド】マルチスライスCT診断

伊藤茂樹, 石垣聡子, 鈴木耕次郎, 岩野信吾, 長縄慎二

臨床画像 Vol. 22 ( 12 ) page： 1334-1342 2006.12

Application of subsecond rotation scan to helical CT for lung cancer screening. Reviewed

Mori Y, Itoh S, Ikeda M, Sawaki A, Suzuki K, Iwano S, Satake H, Arahata S, Ota T, Ishigaki T

Nagoya journal of medical science Vol. 68 ( 3-4 ) page： 139-45 2006.6

Application of subsecond rotation scan to helical CT for lung cancer screening.

Mori, Yoshine; Itoh, Shigeki; Ikeda, Mitsuru; Sawaki, Akiko; Suzuki, Koujiro; Iwano, Shingo; Satake, Hiroko; Arahata, Shoji; Ota, Toyohiro; Ishigaki, Takeo

Nagoya J Med Sci Vol. 68 page： 139-145 2006

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To clarify whether the benefit of a reduced effective scan width obtained using a smaller pitch outweighs the disadvantage of increased noise in the application of a subsecond helical CT to mass screenings for lung cancer. MATERIALS AND METHODS: Twenty-two helical CT scans of the lung were obtained in 11 healthy subjects using the following parameters: 1) scan 1 was performed at 120 kVp, 50 mA, 10-mm collimation, 1-second/rotation, helical pitch of 2.0; and 2) scan 2 was performed at 120 kVp, 50 mA, 10-mm collimation, 0.75-second/rotation, helical pitch of 1.5. Computer-generated nodules measuring 10 mm and 6 mm in diameter showing ground-glass opacity were superimposed on these images. The detectability of each nodule was evaluated by six blinded readers using ROC analysis. RESULTS: Detectability of the 6-mm nodules was significantly higher in scan 2 than in scan 1. Detectability of the 10-mm nodules was not significantly different between scans 1 and 2. CONCLUSION: The use of a smaller pitch by employing a subsecond rotation scan in a helical CT for lung cancer screenings improves the detection of small lesions without increasing either the scanning time or radiation dose.

Diagnostic value of curved multiplanar reformatted images in multislice CT for the detection of resectable pancreatic ductal adenocarcinoma.

Fukushima H, Itoh S, Takada A, Mori Y, Suzuki K, Sawaki A, Iwano S, Satake H, Ota T, Ikeda M, Ishigaki T

Eur Radiol Vol. 16 page： 1709-1718 2006

Language：English Publishing type：Research paper (scientific journal)

The purpose of this study was to assess the usefulness of curved multiplanar reformatted (MPR) images obtained by multislice CT for the depiction of the main pancreatic duct (MPD) and detection of resectable pancreatic ductal adenocarcinoma. This study included 28 patients with pancreatic carcinoma (size range 12-40 mm) and 22 without. Curved MPR images with 0.5-mm continuous slices were generated along the long axis of the pancreas from pancreatic-phase images with a 0.5- or 1-mm slice thickness. Seven blinded readers independently interpreted three sets of images (axial images, curved MPR images, and both axial and curved MPR images) in scrolling mode. The depiction of the MPD and the diagnostic performance for the detection of carcinoma were statistically compared among these images. MPR images were significantly superior to axial images in depicting the MPD, and the use of both axial and MPR images resulted in further significant improvements. For the detection of carcinoma, MPR images were equivalent to axial images, and the diagnostic performance was significantly improved by the use of both axial and MPR images. High-resolution curved MPR images can improve the depiction of the MPD and the diagnostic performance for the detection of carcinoma compared with axial images alone.

Cerebral glucose metabolism change in patients with complex regional pain syndrome: a PET study.

Shiraishi S, Kobayashi H, Nihashi T, Kato K, Iwano S, Nishino M, Ishigaki T, Ikeda M, Kato T, Ito K, Kimura T

Radiat Med Vol. 24 page： 335-344 2006

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: The aim of this study was to examine abnormalities of the central nervous system in patients with chronic pain who were diagnosed with complex regional pain syndrome (CRPS). MATERIALS AND METHODS: Brain activity was assessed using (18)F-fluorodeoxyglucose positron emission tomography. The data collected from 18 patients were compared with data obtained from 13 normal age-matched controls. RESULTS: Our results showed that glucose metabolism was bilaterally increased in the secondary somatosensory cortex, mid-anterior cingulated cortex (ACC) or posterior cingulated cortex (PCC) (or both), parietal cortex, posterior parietal cortex (PPC), and cerebellum as well as in the right posterior insula and right thalamus in our patients. In contrast, glucose metabolism was reduced contralaterally in the dorsal prefrontal cortex and primary motor cortex. Glucose metabolism was bilaterally elevated in the mid-ACC/PCC and the PPC, which correlated with pain duration. CONCLUSION: These data suggested that glucose metabolism in the brains of patients with CRPS changes dramatically at each location. In particular, glucose metabolism was increased in the areas concerned with somatosensory perception, possibly due to continuous painful stimulation.

皮膚原発悪性黒色腫と転移巣における123I-IMPシンチグラフィ　18F-FDG PETとの比較

加藤克彦, 伊藤信嗣, 岩野信吾, 石垣武男, 池田充, 田所匡典, 小林英敏

核医学 Vol. 43 page： 360 2006

甲状腺癌の骨転移診断における18F－FDG－ペTと骨シンチグラフィの比較

伊藤信嗣、加藤克彦、岩野信吾、石垣武男、田所匡典、牧野直樹、池田充

核医学 Vol. 43 page： 95 2006

*Computer-aided diagnosis: A shape classification of pulmonary nodules imaged by high-resolution CT. Reviewed

Iwano S, Nakamura T, Kamioka Y, Ishigaki T

Comput Med Imaging Graph. Vol. 29 ( 7 ) page： 565-570 2005

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

We investigated the possibility of using computer analysis of high-resolution CT images to radiologically classify the shape of pulmonary nodules. Using a combination of circularity and second moment as quantitative measures we were able to classify pulmonary nodules in each shape group as effectively as could a radiologist. We found that pulmonary nodules with circularity < or =0.75 and second moment < or =0.18 were very likely to reveal lung cancer.

Three-phase CT examination of the pancreatobiliary region using multislice CT with 1-mm collimation.

Itoh S, Suzuki K, Iwano S, Satake H, Ota T, Ikeda M, Ishigaki T

Radiat Med Vol. 23 page： 283-291 2005

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To evaluate the degree of contrast enhancement and accuracy of imaging of the circulatory phase in the first-pass, second-pass, and third-pass acquisitions in the pancreato-biliary region with 1-mm collimation obtained by multislice computed tomography (CT). MATERIALS AND METHODS: In 53 patients, two sequential acquisitions from the porta hepatis to the pancreas were performed during a single breath-hold, followed by a third-pass acquisition including the liver beginning 15 sec after the second-pass acquisition. Contrast enhancement in each acquisition was measured in the aorta, portal vein and its branches, and pancreas. Four experienced radiologists graded using four-point scoring whether or not each acquisition was appropriate for imaging of the arterial phase, pancreatic phase, and portal venous phase. RESULTS: Aortic enhancement was highest at the beginning of the second-pass acquisition. The portal and splenic veins and pancreas showed maximum enhancement in the second-pass acquisition, while the superior mesenteric vein showed maximum enhancement in the third-pass acquisition. In the visual assessment, significantly higher grades were achieved in the first-pass, second-pass, and third-pass acquisitions with regard to imaging of the arterial phase, pancreatic phase, and portal venous phase, respectively. CONCLUSION: Multislice CT permits the acquisition of three distinct circulatory phases (arterial, pancreatic, and portal venous phases) in the pancreatobiliary region with 1-mm collimation.

Branch duct-type intraductal papillary mucinous tumor: diagnostic value of multiplanar reformatted images in multislice CT.

Takada A, Itoh S, Suzuki K, Iwano S, Satake H, Ota T, Ikeda M, Ishigaki T

Eur Radiol Vol. 15 page： 1888-1897 2005

Language：English Publishing type：Research paper (scientific journal)

The object of this study was to evaluate the usefulness of high-resolution multiplanar reformatted (MPR) images obtained by multislice CT in demonstrating connection between pancreatic cystic lesions and the main pancreatic duct. The study included 27 lesions with connection to the main pancreatic duct and 12 lesions without. All but one of the former lesions were branch duct-type intraductal papillary mucinous tumors (IPMTs). Oblique and curved MPR images with 0.5 mm continuous slices were generated from pancreatic-phase axial images reconstructed with 0.5 mm or 1 mm thickness at 0.5 mm intervals over a 260 mm field of view. The diagnostic capabilities for demonstrating connection with the main pancreatic duct were compared among axial images, MPR images, and both axial and MPR images in combination using the Brier score. The diagnosis in MPR images for demonstrating connection was more certain than that in axial images (P<0.05). Compared with MPR images alone, the use of both axial and MPR images resulted in further improvements in diagnostic performance, although the difference was not statistically significant. The use of high-resolution MPR images significantly improves diagnostic performance for demonstrating connection between pancreatic cystic lesions and the main pancreatic duct, which is useful for the diagnosis of branch duct-type IPMT.

Solitary pulmonary nodules: Optimal slice thickness of high-resolution CT in differentiating malignant from benign. Reviewed

Iwano S, Makino N, Ikeda M, Itoh S, Tadokoro M, Satake H, Ishigaki T

Clinical Imaging Vol. 28 page： 322-328 2004

Late-arterial and portal-venous phase imaging of the liver with a multislice CT scanner in patients without circulatory disturbances: automatic bolus tracking or empirical scan delay?

Itoh S, Ikeda M, Achiwa M, Satake H, Iwano S, Ishigaki T

Eur Radiol Vol. 14 page： 1665-1673 2004

Language：English Publishing type：Research paper (scientific journal)

The value of automatic bolus tracking in late-arterial and portal-venous phase imaging of the liver with a multislice CT scanner as compared with fixed time-delay examination in patients without circulatory disturbances is evaluated. For the evaluation of known or suspected liver disease, 98 multiphase contrast-enhanced CT examinations including double late-arterial phase imaging were randomized into either scanning with a scan delay of 30 s from the beginning of contrast material injection or scanning with automatic bolus tracking. Contrast material was injected at 0.07 ml/kg body weight/s over 30 s. Contrast enhancement in each acquisition was measured in the aorta, portal vein, liver, pancreas and hepatocellular carcinomas. The density difference between hepatocellular carcinomas and the hepatic parenchyma was calculated. The mean time to the first-pass acquisition as determined by automatic bolus tracking was 29.6 s. No statistically significant difference was observed between the two groups either in any enhancement in any acquisition or in the lesion-to-liver density difference. The use of automatic bolus tracking in late-arterial and portal-venous phase hepatic CT does not significantly improve the degree of contrast enhancement in the aorta, portal vein, liver and pancreas or lesion-to-liver conspicuity in patients without circulatory disturbances.

Lung: feasibility of a method for changing tube current during low-dose helical CT.

Itoh S, Ikeda M, Mori Y, Suzuki K, Sawaki A, Iwano S, Satake H, Arahata S, Isomura T, Ozaki M, Ishigaki T

Radiology Vol. 224 page： 905-912 2002

Language：English Publishing type：Research paper (scientific journal)

A method for changing the tube current during helical scanning was applied to low-dose computed tomography (CT) in the lung. The changing method resulted in significant equalization of image noise in various lung sections compared with that at scanning with constant tube current. Detectability of nodules was equivalent between 60 mA and the changing method, whereas degradation occurred at 20 mA. This method seems feasible for the low-dose CT of lung cancer screening.

Detection of Subtle Pulmonary Disease on CR Chest Images: Monochromatic CRT Monitor vs. Color CRT Monitor Reviewed

Iwano S, Ishigaki T, Shimamoto K, Inamura K, Maeda T, Ikeda M, Ishiguchi T, Kozuka T

European Radiology Vol. 11 ( 1 ) page： 59-94 2001.1

Further reduction of radiation dose in helical CT for lung cancer screening using small tube current and a newly designed filter.

Itoh S, Koyama S, Ikeda M, Ozaki M, Sawaki A, Iwano S, Ishigaki T

J Thorac Imaging Vol. 16 page： 81-88 2001

Language：English Publishing type：Research paper (scientific journal)

A new aluminum filter, 5.8 mm thick at the center, was designed. The effective energy, exposure dose, absorbed dose, and noise were measured by using low-dose technique, very low-dose technique with a conventional filter, and very low-dose technique with a new filter on a chest phantom. Accuracy of very low-dose computed tomography (CT) with a new filter was compared against standard helical CT in 40 patients and against chest radiography in 35 patients. Effective energies were 42.6 keV and 51.6 keV at a conventional filter and the new filter, respectively. Compared against 20mA with a conventional filter, exposure dose was reduced by 17%, and absorbed dose was equivalent, at 30 mA with the new filter. Noise was improved by 9%. Compared with standard helical CT, the sensitivity, specificity, and accuracy of very-low-dose helical CT were 100%, 88%, and 95%, respectively. Very-low-dose helical CT was found to be significantly superior to chest radiography in the detection of lung cancers. Using a smaller tube current and an appropriate filter allows a further reduction in radiation dose in helical CT for lung cancer screening.

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